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href="https://massgeneral.academia.edu/">Massachusetts General Hospital</a>, <a class="u-tcGrayDarker" href="https://massgeneral.academia.edu/Departments/Department_of_Gastroenterology/Documents">Department of Gastroenterology</a>, <span class="u-tcGrayDarker">Post-Doc</span></div><div><a class="u-tcGrayDarker" href="https://griffith.academia.edu/">Griffith University</a>, <a class="u-tcGrayDarker" href="https://griffith.academia.edu/Departments/School_of_Medical_Science/Documents">School of Medical Science</a>, <span class="u-tcGrayDarker">Adjunct</span></div></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="Nirajan" data-follow-user-id="24453968" data-follow-user-source="profile_button" data-has-google="false"><span class="material-symbols-outlined" style="font-size: 20px" 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class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Nirajan Shrestha, PhD</h3></div><div class="js-work-strip profile--work_container" data-work-id="103486046"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/103486046/Changes_in_Essential_Fatty_Acids_and_Ileal_Genes_Associated_with_Metabolizing_Enzymes_and_Fatty_Acid_Transporters_in_Rodent_Models_of_Cystic_Fibrosis"><img alt="Research paper thumbnail of Changes in Essential Fatty Acids and Ileal Genes Associated with Metabolizing Enzymes and Fatty Acid Transporters in Rodent Models of Cystic Fibrosis" class="work-thumbnail" src="https://attachments.academia-assets.com/103480790/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/103486046/Changes_in_Essential_Fatty_Acids_and_Ileal_Genes_Associated_with_Metabolizing_Enzymes_and_Fatty_Acid_Transporters_in_Rodent_Models_of_Cystic_Fibrosis">Changes in Essential Fatty Acids and Ileal Genes Associated with Metabolizing Enzymes and Fatty Acid Transporters in Rodent Models of Cystic Fibrosis</a></div><div class="wp-workCard_item"><span>International Journal of Molecular Sciences</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cystic fibrosis (CF), the result of mutations in the CF transmembrane conductance regulator (CFTR...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cystic fibrosis (CF), the result of mutations in the CF transmembrane conductance regulator (CFTR), causes essential fatty acid deficiency. The aim of this study was to characterize fatty acid handling in two rodent models of CF; one strain which harbors the loss of phenylalanine at position 508 (Phe508del) in CFTR and the other lacks functional CFTR (510X). Fatty acid concentrations were determined using gas chromatography in serum from Phe508del and 510X rats. The relative expression of genes responsible for fatty acid transport and metabolism were quantified using real-time PCR. Ileal tissue morphology was assessed histologically. There was an age-dependent decrease in eicosapentaenoic acid and the linoleic acid:α-linolenic acid ratio, a genotype-dependent decrease in docosapentaenoic acid (n-3) and an increase in the arachidonic acid:docosahexaenoic acid ratio in Phe508del rat serum, which was not observed in 510X rats. In the ileum, Cftr mRNA was increased in Phe508del rats but...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bd34e161775b5efee7495a642566d5bb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":103480790,"asset_id":103486046,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/103480790/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="103486046"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="103486046"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 103486046; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="103486045"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/103486045/Essential_Fatty_Acid_Deficiency_in_Cystic_Fibrosis_Disease_Progression_Role_of_Genotype_and_Sex"><img alt="Research paper thumbnail of Essential Fatty Acid Deficiency in Cystic Fibrosis Disease Progression: Role of Genotype and Sex" class="work-thumbnail" src="https://attachments.academia-assets.com/103480789/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/103486045/Essential_Fatty_Acid_Deficiency_in_Cystic_Fibrosis_Disease_Progression_Role_of_Genotype_and_Sex">Essential Fatty Acid Deficiency in Cystic Fibrosis Disease Progression: Role of Genotype and Sex</a></div><div class="wp-workCard_item"><span>Nutrients</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Adequate intake of nutrients such as essential fatty acids (EFA) are critical in cystic fibrosis ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Adequate intake of nutrients such as essential fatty acids (EFA) are critical in cystic fibrosis (CF). The clinical course of deterioration of lung function in people with CF has been shown to relate to nutrition. Independent of the higher energy consumption and malabsorption due to pancreatic insufficiency, EFA deficiency is closely associated with the risk of pulmonary infection, the most significant pathology in CF. This review will focus on the EFA deficiency identified in people with CF, as well as the limited progress made in deciphering the exact metabolic pathways that are dysfunctional in CF. Specifically, people with CF are deficient in linoleic acid, an omega 6 fatty acid, and the ratio of arachidonic acid (omega 6 metabolite) and docosahexaenoic acid (omega 3 metabolite) is increased. Analysis of the molecular pathways in bronchial cells has identified changes in the enzymes that metabolise EFA. However, fatty acid metabolism primarily occurs in the liver, with EFA metab...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2f365ef5ff92fd7f569b3b423796b8ff" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":103480789,"asset_id":103486045,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/103480789/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="103486045"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="103486045"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 103486045; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=103486045]").text(description); $(".js-view-count[data-work-id=103486045]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 103486045; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='103486045']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2f365ef5ff92fd7f569b3b423796b8ff" } } $('.js-work-strip[data-work-id=103486045]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":103486045,"title":"Essential Fatty Acid Deficiency in Cystic Fibrosis Disease Progression: Role of Genotype and Sex","internal_url":"https://www.academia.edu/103486045/Essential_Fatty_Acid_Deficiency_in_Cystic_Fibrosis_Disease_Progression_Role_of_Genotype_and_Sex","owner_id":24453968,"coauthors_can_edit":true,"owner":{"id":24453968,"first_name":"Nirajan","middle_initials":null,"last_name":"Shrestha, PhD","page_name":"NirajanShrestha","domain_name":"massgeneral","created_at":"2015-01-06T20:06:09.191-08:00","display_name":"Nirajan Shrestha, PhD","url":"https://massgeneral.academia.edu/NirajanShrestha"},"attachments":[{"id":103480789,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/103480789/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/103480789/download_file","bulk_download_file_name":"Essential_Fatty_Acid_Deficiency_in_Cysti.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/103480789/pdf-libre.pdf?1687031708=\u0026response-content-disposition=attachment%3B+filename%3DEssential_Fatty_Acid_Deficiency_in_Cysti.pdf\u0026Expires=1739924162\u0026Signature=crbHBRkyQNSIy1gPs6xSEzeZHLuTZvpmn460vyCpiVAsMJyQ7uch8qAzj9uTaKAtjd6lcpQKTBOoSX~o0KBwzFCO6ZZiInY4i84Io-EfTsuw-IVNRYBpp07CiRkqre7mLNYHNz8IF6jQ3zo8J3TnsQqBaqlQLQO373GBN8OI9aQJT~Y4OC~ZNEx3r-6kZLvQBr~~M8snPeUtveYVUrmU4kkl8EnqrawTew1Nx5Kk7OKlx-lporOz~UHO1J3~37IPsem~DTfK4JBngqrSPJnJdI~Y3m5fyYmrYbfPsav8gAKQEx9IxV9vd5LR~VEVaz5B8foptDKtZjXi1Xv8NQCGAA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689883"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87689883/PE_149_Association_of_Serum_Aminotransferases_with_High_Density_Lipoprotein_Cholesterol_HDL_C_in_Diabetic_Patients"><img alt="Research paper thumbnail of PE-149: Association of Serum Aminotransferases with High Density Lipoprotein Cholesterol (HDL-C) in Diabetic Patients" class="work-thumbnail" src="https://attachments.academia-assets.com/91831171/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87689883/PE_149_Association_of_Serum_Aminotransferases_with_High_Density_Lipoprotein_Cholesterol_HDL_C_in_Diabetic_Patients">PE-149: Association of Serum Aminotransferases with High Density Lipoprotein Cholesterol (HDL-C) in Diabetic Patients</a></div><div class="wp-workCard_item"><span>춘·추계 학술대회 (KASL)</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Conclusions: NAFLD is associated with changes in biochemical parameters in cases of NAFLD. Its ea...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Conclusions: NAFLD is associated with changes in biochemical parameters in cases of NAFLD. Its early detection will help in modifying the disease course, delaying complications and will also play a major role in preventive cardiology.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6a717f7a8df47821578b67a767e80d27" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91831171,"asset_id":87689883,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91831171/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689883"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689883"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689883; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6a717f7a8df47821578b67a767e80d27" } } $('.js-work-strip[data-work-id=87689883]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87689883,"title":"PE-149: Association of Serum Aminotransferases with High Density Lipoprotein Cholesterol (HDL-C) in Diabetic Patients","internal_url":"https://www.academia.edu/87689883/PE_149_Association_of_Serum_Aminotransferases_with_High_Density_Lipoprotein_Cholesterol_HDL_C_in_Diabetic_Patients","owner_id":24453968,"coauthors_can_edit":true,"owner":{"id":24453968,"first_name":"Nirajan","middle_initials":null,"last_name":"Shrestha, PhD","page_name":"NirajanShrestha","domain_name":"massgeneral","created_at":"2015-01-06T20:06:09.191-08:00","display_name":"Nirajan Shrestha, PhD","url":"https://massgeneral.academia.edu/NirajanShrestha"},"attachments":[{"id":91831171,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/91831171/thumbnails/1.jpg","file_name":"fulltext.pdf","download_url":"https://www.academia.edu/attachments/91831171/download_file","bulk_download_file_name":"PE_149_Association_of_Serum_Aminotransfe.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/91831171/fulltext-libre.pdf?1664653265=\u0026response-content-disposition=attachment%3B+filename%3DPE_149_Association_of_Serum_Aminotransfe.pdf\u0026Expires=1739924162\u0026Signature=VJC9blLeQjiwaghzwpIPSQxl-I68tK~aOvSuGyJJa67-CoNDSlcLhiYWI~a3ZfIxa-wftK-eEcB~nJG2hjqHHOAbYReTYfk-2FSay40EPD1dGcP0IXbasWm5P79fDzSZcK1D1UuEGYwQIrWscRaspfX1t4MCMRamv5QW4bRnCjRjNuKzHBKvYmyF6yGKLPgtPJm9afqYvc~VmbBESxNK6m46sCCIvKWs4e1M3l8PaODywIPrLlS5-T4XiJUd0UapUK5uCwP9BQLwP5sA4X0jCT577Bs6e-FZA-jaHiWrsHUHgjXwNW1Zn4UEoacUWPX93fspVFfiiHfICjdP3o4R8g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689882"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/87689882/Maternal_and_postnatal_diet_high_in_linoleic_acid_alters_fatty_acid_composition_cholesterol_and_hepatic_gene_expression_in_adult_offspring_in_a_sex_specific_manner"><img alt="Research paper thumbnail of Maternal and postnatal diet high in linoleic acid alters fatty acid composition, cholesterol and hepatic gene expression, in adult offspring in a sex‐specific manner" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/87689882/Maternal_and_postnatal_diet_high_in_linoleic_acid_alters_fatty_acid_composition_cholesterol_and_hepatic_gene_expression_in_adult_offspring_in_a_sex_specific_manner">Maternal and postnatal diet high in linoleic acid alters fatty acid composition, cholesterol and hepatic gene expression, in adult offspring in a sex‐specific manner</a></div><div class="wp-workCard_item"><span>The FASEB Journal</span><span>, 2021</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689882"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689882"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689882; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87689882]").text(description); $(".js-view-count[data-work-id=87689882]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87689882; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87689882']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=87689882]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87689882,"title":"Maternal and postnatal diet high in linoleic acid alters fatty acid composition, cholesterol and hepatic gene expression, in adult offspring in a sex‐specific manner","internal_url":"https://www.academia.edu/87689882/Maternal_and_postnatal_diet_high_in_linoleic_acid_alters_fatty_acid_composition_cholesterol_and_hepatic_gene_expression_in_adult_offspring_in_a_sex_specific_manner","owner_id":24453968,"coauthors_can_edit":true,"owner":{"id":24453968,"first_name":"Nirajan","middle_initials":null,"last_name":"Shrestha, PhD","page_name":"NirajanShrestha","domain_name":"massgeneral","created_at":"2015-01-06T20:06:09.191-08:00","display_name":"Nirajan Shrestha, PhD","url":"https://massgeneral.academia.edu/NirajanShrestha"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689881"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87689881/PE_148_Waist_Circumference_Not_Body_Mass_Index_Is_Associated_with_Increased_Gamma_glutamyltranspeptidase_in_Type_Diabetes_Mellitus"><img alt="Research paper thumbnail of PE-148: Waist Circumference, Not Body Mass Index, Is Associated with Increased Gamma-glutamyltranspeptidase in Type Diabetes Mellitus" class="work-thumbnail" src="https://attachments.academia-assets.com/91831211/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87689881/PE_148_Waist_Circumference_Not_Body_Mass_Index_Is_Associated_with_Increased_Gamma_glutamyltranspeptidase_in_Type_Diabetes_Mellitus">PE-148: Waist Circumference, Not Body Mass Index, Is Associated with Increased Gamma-glutamyltranspeptidase in Type Diabetes Mellitus</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aims: Serum gamma-glutamyltranspeptidase ( GGT), a marker of liver injury, alcohol consumption, a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aims: Serum gamma-glutamyltranspeptidase ( GGT), a marker of liver injury, alcohol consumption, and oxidative stress, has been shown to be associated with obesity and diabetes mellitus. Obese individuals with higher GGT are associated with complications in type 2 diabetic patients. There is evidence that waist circumference (WC) measured obesity more accurately than body mass index (BMI). In the present study, we aimed to evaluate association of GGT with WC and BMI in diabetic subjects. Methods: The study subjects were 105 type 2 diabetic patients (39 men and 66 women), who attended outpatient department of Nepal Medical College Teaching Hospital, Kathmandu, Nepal. The patients with the history of alcohol intake and liver disease were excluded from the study. Anthropometric measurement was taken and venous blood was collected for biochemical analysis. Statistical analysis was done using SPSS 16.0. The p-values less than 0.05 were considered as significant. Results: The serum GGT lev...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a0db354fd2d9ee4c57082040d024d0f3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91831211,"asset_id":87689881,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91831211/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689881"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689881"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689881; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689880"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/87689880/Role_of_High_Maternal_Linoleic_Acid_on_Offspring_Health"><img alt="Research paper thumbnail of Role of High Maternal Linoleic Acid on Offspring Health" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/87689880/Role_of_High_Maternal_Linoleic_Acid_on_Offspring_Health">Role of High Maternal Linoleic Acid on Offspring Health</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Maternal nutrition during pregnancy plays a critical role in the adult-onset of disease in a moth...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Maternal nutrition during pregnancy plays a critical role in the adult-onset of disease in a mother’s children. The first 1000 days, spanning from conception to two years of life, are an important period when appropriate nutritional needs must be ensured for long-term health. Studies have shown that inadequate nutritional condition in utero and early life increases the risk of developing chronic conditions later in life. In recent years, the intake of linoleic acid (LA) has increased gradually in human populations, due to changes in a dietary pattern that have resulted in increased consumption of vegetable oils and foods processed in vegetable oils. LA is an omega-6 polyunsaturated fatty acid (n-6 PUFA), which is an essential fatty acid required in the human diet. LA plays a vital role in fetal growth and development. Even though LA is essential in our diet, studies have raised concern over its beneficial effect, as excess LA is shown to have pro-inflammatory characteristics. In add...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689880"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689880"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689880; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87689880]").text(description); $(".js-view-count[data-work-id=87689880]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87689880; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87689880']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=87689880]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87689880,"title":"Role of High Maternal Linoleic Acid on Offspring Health","internal_url":"https://www.academia.edu/87689880/Role_of_High_Maternal_Linoleic_Acid_on_Offspring_Health","owner_id":24453968,"coauthors_can_edit":true,"owner":{"id":24453968,"first_name":"Nirajan","middle_initials":null,"last_name":"Shrestha, PhD","page_name":"NirajanShrestha","domain_name":"massgeneral","created_at":"2015-01-06T20:06:09.191-08:00","display_name":"Nirajan Shrestha, PhD","url":"https://massgeneral.academia.edu/NirajanShrestha"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689879"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/87689879/Role_for_animal_models_in_understanding_essential_fatty_acid_deficiency_in_cystic_fibrosis"><img alt="Research paper thumbnail of Role for animal models in understanding essential fatty acid deficiency in cystic fibrosis" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/87689879/Role_for_animal_models_in_understanding_essential_fatty_acid_deficiency_in_cystic_fibrosis">Role for animal models in understanding essential fatty acid deficiency in cystic fibrosis</a></div><div class="wp-workCard_item"><span>Cellular and Molecular Life Sciences</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Essential fatty acid deficiency has been observed in most patients with Cystic Fibrosis (CF); how...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Essential fatty acid deficiency has been observed in most patients with Cystic Fibrosis (CF); however, pancreatic supplementation does not restore the deficiency, suggesting a different pathology independent of the pancreas. At this time, the underlying pathological mechanisms are largely unknown. Essential fatty acids are obtained from the diet and processed by organs including the liver and intestine, two organs significantly impacted by mutations in the cystic fibrosis transmembrane conductance regulator gene (Cftr). There are several CF animal models in a variety of species that have been developed to investigate molecular mechanisms associated with the CF phenotype. Specifically, global and systemic mutations in Cftr which mimic genotypic changes identified in CF patients have been generated in mice, rats, sheep, pigs and ferrets. These mutations produce CFTR proteins with a gating defect, trafficking defect, or an absent or inactive CFTR channel. Essential fatty acids are critical to CFTR function, with a bidirectional relationship between CFTR and essential fatty acids proposed. Currently, there are limited analyses on the essential fatty acid status in most of these animal models. Of interest, in the mouse model, essential fatty acid status is dependent on the genotype and resultant phenotype of the mouse. Future investigations should identify an optimal animal model that has most of the phenotypic changes associated with CF including the essential fatty acid deficiencies, which can be used in the development of therapeutics.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689879"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689879"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689879; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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</script> <div class="js-work-strip profile--work_container" data-work-id="87689878"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87689878/Sex_Specific_Differences_in_Lysine_3_Hydroxybutyric_Acid_and_Acetic_Acid_in_Offspring_Exposed_to_Maternal_and_Postnatal_High_Linoleic_Acid_Diet_Independent_of_Diet"><img alt="Research paper thumbnail of Sex-Specific Differences in Lysine, 3-Hydroxybutyric Acid and Acetic Acid in Offspring Exposed to Maternal and Postnatal High Linoleic Acid Diet, Independent of Diet" class="work-thumbnail" src="https://attachments.academia-assets.com/91831169/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87689878/Sex_Specific_Differences_in_Lysine_3_Hydroxybutyric_Acid_and_Acetic_Acid_in_Offspring_Exposed_to_Maternal_and_Postnatal_High_Linoleic_Acid_Diet_Independent_of_Diet">Sex-Specific Differences in Lysine, 3-Hydroxybutyric Acid and Acetic Acid in Offspring Exposed to Maternal and Postnatal High Linoleic Acid Diet, Independent of Diet</a></div><div class="wp-workCard_item"><span>International Journal of Molecular Sciences</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Linoleic acid (LA) is an essential polyunsaturated fatty acid (PUFA) that is required...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Linoleic acid (LA) is an essential polyunsaturated fatty acid (PUFA) that is required for foetal growth and development. Excess intake of LA can be detrimental for metabolic health due to its pro-inflammatory properties; however, the effect of a diet high in LA on offspring metabolites is unknown. In this study, we aimed to determine the role of maternal or postnatal high linoleic acid (HLA) diet on plasma metabolites in adult offspring. Methods: Female Wistar Kyoto (WKY) rats were fed with either low LA (LLA) or HLA diet for 10 weeks prior to conception and during gestation/lactation. Offspring were weaned at postnatal day 25 (PN25), treated with either LLA or HLA diets and sacrificed at PN180. Metabolite analysis was performed in plasma samples using Nuclear Magnetic Resonance. Results: Maternal and postnatal HLA diet did not alter plasma metabolites in male and female adult offspring. There was no specific clustering among different treatment groups as demonstrated by...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="97209b05bb67acc8cf9df9c485f23bd1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91831169,"asset_id":87689878,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91831169/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689878"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689878"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689878; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689877"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87689877/Maternal_diet_high_in_linoleic_acid_alters_offspring_fatty_acids_and_cardiovascular_function_in_a_rat_model"><img alt="Research paper thumbnail of Maternal diet high in linoleic acid alters offspring fatty acids and cardiovascular function in a rat model" class="work-thumbnail" src="https://attachments.academia-assets.com/91831208/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87689877/Maternal_diet_high_in_linoleic_acid_alters_offspring_fatty_acids_and_cardiovascular_function_in_a_rat_model">Maternal diet high in linoleic acid alters offspring fatty acids and cardiovascular function in a rat model</a></div><div class="wp-workCard_item"><span>British Journal of Nutrition</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Linoleic acid (LA), an essential n-6 fatty acid (FA), is critical for fetal development. We inves...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Linoleic acid (LA), an essential n-6 fatty acid (FA), is critical for fetal development. We investigated the effects of maternal high LA (HLA) diet on offspring cardiac development and its relationship to circulating FA and cardiovascular function in adolescent offspring, and the ability of the postnatal diet to reverse any adverse effects. Female Wistar Kyoto rats were fed low LA (LLA; 1·44 % energy from LA) or high LA (HLA; 6·21 % energy from LA) diets for 10 weeks before pregnancy and during gestation/lactation. Offspring, weaned at postnatal day 25, were fed LLA or HLA diets and euthanised at postnatal day 40 (n 6–8). Maternal HLA diet decreased circulating total cholesterol and HDL-cholesterol in females and decreased total plasma n-3 FA in males, while maternal and postnatal HLA diets decreased total plasma n-3 FA in females. α-Linolenic acid (ALA) and EPA were decreased by postnatal but not maternal HLA diets in both sexes. Maternal and postnatal HLA diets increased total pla...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9a0110dbf7609ab8d67fbff0fbb0b997" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91831208,"asset_id":87689877,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91831208/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689877"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689877"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689877; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689876"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87689876/Developmental_programming_of_peripheral_diseases_in_offspring_exposed_to_maternal_obesity_during_pregnancy"><img alt="Research paper thumbnail of Developmental programming of peripheral diseases in offspring exposed to maternal obesity during pregnancy" class="work-thumbnail" src="https://attachments.academia-assets.com/91831163/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87689876/Developmental_programming_of_peripheral_diseases_in_offspring_exposed_to_maternal_obesity_during_pregnancy">Developmental programming of peripheral diseases in offspring exposed to maternal obesity during pregnancy</a></div><div class="wp-workCard_item"><span>American Journal of Physiology-Regulatory, Integrative and Comparative Physiology</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Obesity is an increasing global health epidemic that affects all ages, including women of reprodu...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Obesity is an increasing global health epidemic that affects all ages, including women of reproductive age. During pregnancy, maternal obesity is associated with adverse pregnancy outcomes that lead to complications for the mother. In addition, maternal obesity can increase the risk of poor perinatal outcomes for the infant due to altered development. Recent research has investigated the effects of maternal obesity on peripheral organ development and health in later life in offspring. In this review, we have summarized studies that investigated the programming effects of maternal obesity before and during pregnancy on metabolic, cardiovascular, immune, and microbiome perturbations in offspring. Epidemiological studies investigating the effects of maternal obesity on offspring development can be complex due to other copathologies and genetic diversity. Animal studies have provided some insights into the specific mechanisms and pathways involved in programming peripheral disease risk....</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="af4557e956b673be4abdad7e823eb158" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91831163,"asset_id":87689876,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91831163/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689876"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689876"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689876; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "af4557e956b673be4abdad7e823eb158" } } $('.js-work-strip[data-work-id=87689876]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87689876,"title":"Developmental programming of peripheral diseases in offspring exposed to maternal obesity during pregnancy","internal_url":"https://www.academia.edu/87689876/Developmental_programming_of_peripheral_diseases_in_offspring_exposed_to_maternal_obesity_during_pregnancy","owner_id":24453968,"coauthors_can_edit":true,"owner":{"id":24453968,"first_name":"Nirajan","middle_initials":null,"last_name":"Shrestha, PhD","page_name":"NirajanShrestha","domain_name":"massgeneral","created_at":"2015-01-06T20:06:09.191-08:00","display_name":"Nirajan Shrestha, PhD","url":"https://massgeneral.academia.edu/NirajanShrestha"},"attachments":[{"id":91831163,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/91831163/thumbnails/1.jpg","file_name":"ajpregu.00214.pdf","download_url":"https://www.academia.edu/attachments/91831163/download_file","bulk_download_file_name":"Developmental_programming_of_peripheral.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/91831163/ajpregu.00214-libre.pdf?1664653276=\u0026response-content-disposition=attachment%3B+filename%3DDevelopmental_programming_of_peripheral.pdf\u0026Expires=1739924162\u0026Signature=XeEnCyowHD2a2NK2Sa7sZr5-wF12zbBCtTnuwGgts9le0wEwSJRwY0kFn5-WpNMEfRLuKOVr6Y7sZhhr5XbR5zSa4prPfOLLR0aFWJ4EqloW44Stma7WK9RoP3OAXUJULSV14zlOpOIir2s0xKtRiopRI0HEmkbz9iUVcV0cwW4mZG2qWrmXApGBkKT4oK9Iu8RuGkkZxE7f4DRN7UwqUn85GpodYZ8TBcYYeFXhEM4dJn5LP8TAF3Tn26BnH~Vbl7BQ6NKsz4HYQ0L8k1AhJPXDknGULe6sBp2wnnBHIFVZqihxhFEOkRtU~mDbJ7LOUFeTLZWZWRNfMbsKm5smDQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689874"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87689874/Maternal_and_Postnatal_High_Linoleic_Acid_Diet_Impacts_Lipid_Metabolism_in_Adult_Rat_Offspring_in_a_Sex_Specific_Manner"><img alt="Research paper thumbnail of Maternal and Postnatal High Linoleic Acid Diet Impacts Lipid Metabolism in Adult Rat Offspring in a Sex-Specific Manner" class="work-thumbnail" src="https://attachments.academia-assets.com/91831162/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87689874/Maternal_and_Postnatal_High_Linoleic_Acid_Diet_Impacts_Lipid_Metabolism_in_Adult_Rat_Offspring_in_a_Sex_Specific_Manner">Maternal and Postnatal High Linoleic Acid Diet Impacts Lipid Metabolism in Adult Rat Offspring in a Sex-Specific Manner</a></div><div class="wp-workCard_item"><span>International Journal of Molecular Sciences</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Linoleic acid (LA), an n-6 polyunsaturated fatty acid (PUFA), is essential for fetal growth and d...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Linoleic acid (LA), an n-6 polyunsaturated fatty acid (PUFA), is essential for fetal growth and development. We aimed to investigate the effect of maternal and postnatal high LA (HLA) diet on plasma FA composition, plasma and hepatic lipids and genes involved in lipid metabolism in the liver of adult offspring. Female rats were fed with low LA (LLA; 1.44% LA) or HLA (6.21% LA) diets for 10 weeks before pregnancy, and during gestation/lactation. Offspring were weaned at postnatal day 25 (PN25), fed either LLA or HLA diets and sacrificed at PN180. Postnatal HLA diet decreased circulating total n-3 PUFA and alpha-linolenic acid (ALA), while increased total n-6 PUFA, LA and arachidonic acid (AA) in both male and female offspring. Maternal HLA diet increased circulating leptin in female offspring, but not in males. Maternal HLA diet decreased circulating adiponectin in males. Postnatal HLA diet significantly decreased aspartate transaminase (AST) in females and downregulated total choles...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="eb64ac68a8986d3881b711036feef20e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91831162,"asset_id":87689874,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91831162/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689874"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689874"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689874; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689873"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87689873/Role_for_endocannabinoids_in_early_pregnancy_recent_advances_and_the_effects_of_cannabis_use"><img alt="Research paper thumbnail of Role for endocannabinoids in early pregnancy: recent advances and the effects of cannabis use" class="work-thumbnail" src="https://attachments.academia-assets.com/91831160/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87689873/Role_for_endocannabinoids_in_early_pregnancy_recent_advances_and_the_effects_of_cannabis_use">Role for endocannabinoids in early pregnancy: recent advances and the effects of cannabis use</a></div><div class="wp-workCard_item"><span>American Journal of Physiology-Endocrinology and Metabolism</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The endocannabinoid system (ECS) is associated with several physiological processes, including re...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The endocannabinoid system (ECS) is associated with several physiological processes, including reproduction. This system consists of the cannabinoid receptors, endocannabinoid ligands, and enzymes that metabolize and degrade these fatty acids. Recent evidence shows that cannabinoid receptors are expressed in cells of the reproductive system, including endometrial stromal cells, ovaries, and sperm cells. Emerging and recent research suggests that the ECS may play a significant role in reproduction. The endocannabinoid ligands anandamide and 2-arachidonoylglycerol are crucial for successful endometrium decidualization, placental development, and embryo implantation. Alteration in cannabinoid receptor expression or in endocannabinoid homeostasis by excessive intake of cannabis during pregnancy is associated with negative pregnancy outcomes, including preterm birth. The use of medicinal cannabis is becoming more widespread in Western countries, especially in people of reproductive age. ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4535eef5147a7dafd6764b47e1de902e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91831160,"asset_id":87689873,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91831160/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689873"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689873"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689873; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689872"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/87689872/Elevated_maternal_linoleic_acid_alters_placental_fatty_acids_nutrient_transporters_and_inflammatory_proteins"><img alt="Research paper thumbnail of Elevated maternal linoleic acid alters placental fatty acids, nutrient transporters and inflammatory proteins" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/87689872/Elevated_maternal_linoleic_acid_alters_placental_fatty_acids_nutrient_transporters_and_inflammatory_proteins">Elevated maternal linoleic acid alters placental fatty acids, nutrient transporters and inflammatory proteins</a></div><div class="wp-workCard_item"><span>The FASEB Journal</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Linoleic acid (LA) is the major omega‐6 fatty acid which is obtained from our diet. During pregna...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Linoleic acid (LA) is the major omega‐6 fatty acid which is obtained from our diet. During pregnancy, LA is required for adequate fetal growth and development. For the growing fetus LA can only be obtained from the maternal diet, and is transferred from the maternal to fetal circulations by the placenta. At this time, in Western societies, we are overconsuming LA during pregnancy. Omega‐6 is metabolised by FADS1 and FADS2, which also metabiolise omega‐3. The ratio of omega‐6 to omega‐3 is important for human health, as they are proinflammatory and anti‐inflammatory, respectively. Therefore, the aim of this study is to determine if elevated maternal LA during pregnancy is alters placental fatty acids, nutrient transporter gene expression and inflammatory proteins. Female Wistar Kyoto rats were fed a diet low in LA (LLA‐1.44% of energy) or diet high in LA (HLA‐6.21% of energy) for 10 weeks before and during gestation. Following mating with a male consuming normal chow, offspring and maternal rats were sacrificed at embryonic day (E)20, and placenta were collected for analysis of placental fatty acids, nutrient transporters and inflammatory markers. In isolated placenta from pregnancies where mothers consumed an elevated LA diet, the concentration of LA was increased and the concentration of the omega‐3 fatty acid a‐linoleinic acid was decreased. Of interest, the downstream metabolite of LA, arachidonic acid was not altered in placenta from mothers consuming an elevated LA diet. mRNA expression of slc27a1 (fatty acid trasnport protein 1) was significantly downregulated in the male placenta from the dams fed with HLA, but not females. The mRNA expression of slc2a1 (glucose trasnporter 1) was significantly decreased in both male and female placenta from mothers fed the HLA diet. Further, the protein concentration of interleukin‐7 (IL‐7) was significantly decreased in both male and female placenta (labyrinth) from the dams fed with HLA, however there were no changes in protein expression of IL‐6 and TNF‐α in the labyrinth. In conclusion, a maternal diet high in LA alters fatty acid concentrations, nutrient transporters and inflammatory cytokines in the placenta. The consequences of this on offspring development, and therefore long term health require further investigation.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689872"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689872"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689872; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87689872]").text(description); $(".js-view-count[data-work-id=87689872]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87689872; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87689872']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=87689872]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87689872,"title":"Elevated maternal linoleic acid alters placental fatty acids, nutrient transporters and inflammatory proteins","internal_url":"https://www.academia.edu/87689872/Elevated_maternal_linoleic_acid_alters_placental_fatty_acids_nutrient_transporters_and_inflammatory_proteins","owner_id":24453968,"coauthors_can_edit":true,"owner":{"id":24453968,"first_name":"Nirajan","middle_initials":null,"last_name":"Shrestha, PhD","page_name":"NirajanShrestha","domain_name":"massgeneral","created_at":"2015-01-06T20:06:09.191-08:00","display_name":"Nirajan Shrestha, PhD","url":"https://massgeneral.academia.edu/NirajanShrestha"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689871"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87689871/Maternal_High_Linoleic_Acid_Alters_Placental_Fatty_Acid_Composition"><img alt="Research paper thumbnail of Maternal High Linoleic Acid Alters Placental Fatty Acid Composition" class="work-thumbnail" src="https://attachments.academia-assets.com/91831154/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87689871/Maternal_High_Linoleic_Acid_Alters_Placental_Fatty_Acid_Composition">Maternal High Linoleic Acid Alters Placental Fatty Acid Composition</a></div><div class="wp-workCard_item"><span>Nutrients</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Fetal development is modulated by maternal nutrition during pregnancy. The dietary intake of lino...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Fetal development is modulated by maternal nutrition during pregnancy. The dietary intake of linoleic acid (LA), an essential dietary n-6 polyunsaturated fatty acid (PUFA), has increased. We previously published that increased LA consumption during pregnancy does not alter offspring or placental weight but fetal plasma fatty acid composition; the developing fetus obtains their required PUFA from the maternal circulation. However, it is unknown if increased maternal linoleic acid alters placental fatty acid storage, metabolism, transport, and general placental function. Female Wistar-Kyoto rats were fed either a low LA diet (LLA; 1.44% of energy from LA) or high LA diet (HLA; 6.21% of energy from LA) for 10 weeks before pregnancy and during gestation. Rats were sacrificed at embryonic day 20 (E20, term = 22 days) and placentae collected. The labyrinth of placentae from one male and one female fetus from each litter were analyzed. High maternal LA consumption increased placental total...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1152657ed71476bcd276ce7f84d7b06d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91831154,"asset_id":87689871,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91831154/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689871"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689871"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689871; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1152657ed71476bcd276ce7f84d7b06d" } } $('.js-work-strip[data-work-id=87689871]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87689871,"title":"Maternal High Linoleic Acid Alters Placental Fatty Acid Composition","internal_url":"https://www.academia.edu/87689871/Maternal_High_Linoleic_Acid_Alters_Placental_Fatty_Acid_Composition","owner_id":24453968,"coauthors_can_edit":true,"owner":{"id":24453968,"first_name":"Nirajan","middle_initials":null,"last_name":"Shrestha, PhD","page_name":"NirajanShrestha","domain_name":"massgeneral","created_at":"2015-01-06T20:06:09.191-08:00","display_name":"Nirajan Shrestha, PhD","url":"https://massgeneral.academia.edu/NirajanShrestha"},"attachments":[{"id":91831154,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/91831154/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/91831154/download_file","bulk_download_file_name":"Maternal_High_Linoleic_Acid_Alters_Place.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/91831154/pdf-libre.pdf?1664653272=\u0026response-content-disposition=attachment%3B+filename%3DMaternal_High_Linoleic_Acid_Alters_Place.pdf\u0026Expires=1739924163\u0026Signature=MnXLUAYi9N4TmW78lEIC1BJaojgiAGOMx5GdqjwHENhOjdn-ysULDjcmFiHYTedhaGoJAtq1RSQTm4pLCC0u-45F9pc3DJy0DgOtPzomQHXchEKqS4IKr5ynYBQywbUs64wXGLFVtkpDbQeHdidQXceT6E1zzHlrKu-o3xNdGwjo3FaWP6hxfukJFiMZ6ZRraiiryp6tMm43TzYSeSsjKfY8erYS~9ZE2sI~yDoUYX~gUJ7uuD5BQvPUBQd5dSQeAAVinBRW67BNCrMGsVA3w--TuQMCKHxSBSWQCNxVwmBuj9F0dGzSVJeWiwR5rgJ4EvWRJVe1RmwfIKfgMWiIYw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689870"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/87689870/Role_of_a_Maternal_Diet_High_in_Linoleic_Acid_on_the_Plasma_Fatty_Acid_Composition_in_Rat_Offspring"><img alt="Research paper thumbnail of Role of a Maternal Diet High in Linoleic Acid on the Plasma Fatty Acid Composition in Rat Offspring" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/87689870/Role_of_a_Maternal_Diet_High_in_Linoleic_Acid_on_the_Plasma_Fatty_Acid_Composition_in_Rat_Offspring">Role of a Maternal Diet High in Linoleic Acid on the Plasma Fatty Acid Composition in Rat Offspring</a></div><div class="wp-workCard_item"><span>The FASEB Journal</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Linoleic acid (LA) is a major omega‐6 polyunsaturated fatty acid (PUFA) which is essential in our...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Linoleic acid (LA) is a major omega‐6 polyunsaturated fatty acid (PUFA) which is essential in our diet. LA is an important fatty acid for fetal growth and development and is transported from mother to fetus through the placenta. Dietary intake of LA has increased significantly in western societies primarily due to increased consumption of vegetable oils. Conversely, the consumption of alpha‐linolenic acid (ALA), an omega‐3 PUFA, has remained similar or decreased due to limited consumption of fish. Metabolites of omega‐3 PUFAs such as docosahexaenoic (DHA) and eicosapentaenoic (EPA) have critical roles in fetal neural development and may influence brain function in later in life. The aim of this study is to investigate the effect of a maternal diet high in LA on offspring fatty acid composition at 40 days of age (adolescence). Female rats were fed with either low LA diet (LLA; 1.44% of energy from LA) or high LA (HLA; 6.21% of energy from LA) with matched ALA (0.3% of energy) for 10 weeks before pregnancy and during gestation. The pups were weaned at postnatal day 25 (PN25) and fed with either LLA or HLA diet (Four groups ‐ LL, LH, HL, HH; first letter denotes maternal diet and second letter denotes post‐weaning diet). The offspring were sacrificed at postnatal day 40 and biological samples were collected and stored at −80°C. The concentration of fatty acids in plasma was quantified using gas chromatography. Total omega‐6 fatty acid (FA) and LA levels in plasma were significantly elevated in the offspring fed with HLA diet at weaning and offspring from dams fed with HLA (LH, HL, HH) compared to offspring from LLA dams fed with LLA at weaning (LL) both in male and female offspring. Total omega‐3 FA was significantly decreased in offspring from HLA dams fed with HLA diet (HH) at weaning in comparison to offspring from LLA dams fed with LLA at weaning (LL). The concentration of ALA was significantly decreased in male offspring from HLA dams fed with HLA diet (HH) compared to HL offspring; however, there was no difference in female offspring. In addition, the plasma level of EPA was significantly decreased in male offspring fed with HLA diet at weaning (LH and HH) compared with LL offspring; however, there was no difference in female offspring. Moreover, DHA, an important omega‐3 FA for brain development, was significantly decreased in HH offspring compared to LL offspring. Hence, the findings from the current study suggest that elevated LA in both maternal diet and weaning diet influence the plasma fatty acid composition in adolescent offspring in a rat model.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689870"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689870"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689870; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87689870]").text(description); $(".js-view-count[data-work-id=87689870]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87689870; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87689870']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=87689870]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87689870,"title":"Role of a Maternal Diet High in Linoleic Acid on the Plasma Fatty Acid Composition in Rat Offspring","internal_url":"https://www.academia.edu/87689870/Role_of_a_Maternal_Diet_High_in_Linoleic_Acid_on_the_Plasma_Fatty_Acid_Composition_in_Rat_Offspring","owner_id":24453968,"coauthors_can_edit":true,"owner":{"id":24453968,"first_name":"Nirajan","middle_initials":null,"last_name":"Shrestha, PhD","page_name":"NirajanShrestha","domain_name":"massgeneral","created_at":"2015-01-06T20:06:09.191-08:00","display_name":"Nirajan Shrestha, PhD","url":"https://massgeneral.academia.edu/NirajanShrestha"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689869"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87689869/Role_of_omega_6_and_omega_3_fatty_acids_in_fetal_programming"><img alt="Research paper thumbnail of Role of omega‐6 and omega‐3 fatty acids in fetal programming" class="work-thumbnail" src="https://attachments.academia-assets.com/91831209/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87689869/Role_of_omega_6_and_omega_3_fatty_acids_in_fetal_programming">Role of omega‐6 and omega‐3 fatty acids in fetal programming</a></div><div class="wp-workCard_item"><span>Clinical and Experimental Pharmacology and Physiology</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Maternal nutrition plays a critical role in fetal development and can influence adult onset of di...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Maternal nutrition plays a critical role in fetal development and can influence adult onset of disease. Linoleic acid (LA) and alpha-linolenic acid (ALA) are major omega-6 (n-6) and n-3 polyunsaturated fatty acids (PUFA), respectively, that are essential in our diet. LA and ALA are critical for the development of the fetal neurological and immune systems. However, in recent years, the consumption of n-6 PUFA has increased gradually worldwide, and elevated n-6 PUFA consumption may be harmful to human health. Consumption of diets with high levels of n-6 PUFA before or during pregnancy may have detrimental effects on fetal development and may influence overall health of offspring in adulthood. This review discusses the role of n-6 PUFA in fetal programming, the importance of a balance between n-6 and n-3 PUFAs in the maternal diet, and the need of further animal models and human studies that critically evaluate both n-6 and n-3 PUFA contents in diets.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="38f480c7a889742cc9210b4ff53363cb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91831209,"asset_id":87689869,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91831209/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689869"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689869"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689869; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "38f480c7a889742cc9210b4ff53363cb" } } $('.js-work-strip[data-work-id=87689869]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87689869,"title":"Role of omega‐6 and omega‐3 fatty acids in fetal programming","internal_url":"https://www.academia.edu/87689869/Role_of_omega_6_and_omega_3_fatty_acids_in_fetal_programming","owner_id":24453968,"coauthors_can_edit":true,"owner":{"id":24453968,"first_name":"Nirajan","middle_initials":null,"last_name":"Shrestha, PhD","page_name":"NirajanShrestha","domain_name":"massgeneral","created_at":"2015-01-06T20:06:09.191-08:00","display_name":"Nirajan Shrestha, PhD","url":"https://massgeneral.academia.edu/NirajanShrestha"},"attachments":[{"id":91831209,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/91831209/thumbnails/1.jpg","file_name":"1440-1681.pdf","download_url":"https://www.academia.edu/attachments/91831209/download_file","bulk_download_file_name":"Role_of_omega_6_and_omega_3_fatty_acids.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/91831209/1440-1681-libre.pdf?1664653281=\u0026response-content-disposition=attachment%3B+filename%3DRole_of_omega_6_and_omega_3_fatty_acids.pdf\u0026Expires=1739924163\u0026Signature=Z-uugHI~~JBkipTaZ2Uz~bxCU4e1ds-nhT~puB9ul99jcnufajUS~kaBDsVTASMElQoGck3I3LxQjaSJhDU0BahIf4kQPFzj1BqIoBhN6T8xDe02BpVEpurUvsKMbTIDxbMn76VsTjupaciU2QPerv4Re2F1idZBfrtMPN6dpkzAzhr4GbE70s1~HnVc2MEOMn8XL1JRlh64agEkGyBuicD7vr-7Ie9HdWQtCMLn~vzsVkXFKiYeDV-Ny-rrTOo~irb3Ag4kIEez51JGYRpWNZx8-Kwir-Sh~RI~O6VkIlxmU4aNpaAbXZEecuKbik2Mmv7SjYCEaFxmabflLJBD-A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689868"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87689868/Pregnancy_and_diet_related_changes_in_the_maternal_gut_microbiota_following_exposure_to_an_elevated_linoleic_acid_diet"><img alt="Research paper thumbnail of Pregnancy and diet-related changes in the maternal gut microbiota following exposure to an elevated linoleic acid diet" class="work-thumbnail" src="https://attachments.academia-assets.com/91831164/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87689868/Pregnancy_and_diet_related_changes_in_the_maternal_gut_microbiota_following_exposure_to_an_elevated_linoleic_acid_diet">Pregnancy and diet-related changes in the maternal gut microbiota following exposure to an elevated linoleic acid diet</a></div><div class="wp-workCard_item"><span>American Journal of Physiology-Endocrinology and Metabolism</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Dietary intakes of linoleic acid (LA) have increased, including in women of reproductive age. Cha...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Dietary intakes of linoleic acid (LA) have increased, including in women of reproductive age. Changes in maternal gut microbiome have been implicated in the metabolic adaptions that occur during pregnancy. We aimed to investigate whether consumption of a diet with elevated LA altered fecal microbiome diversity before and during pregnancy. Female Wistar-Kyoto rats consumed a high-LA diet (HLA: 6.21% of energy) or a low-LA diet (LLA: 1.44% of energy) for 10 wk before mating and during pregnancy. DNA was isolated from fecal samples before pregnancy [embryonic day 0 (E0)], or during pregnancy at E10 and E20. The microbiome composition was assessed with 16S rRNA sequencing. At E0, the beta-diversity of LLA and HLA groups differed with HLA rats having significantly lower abundance of the genera Akkermansia, Peptococcus, Sutterella, and Xo2d06 but higher abundance of Butyricimonas and Coprococcus. Over gestation, in LLA but not HLA rats, there was a reduction in alpha-diversity and an incr...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e867478c82ca4f33068414721be1eb0e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91831164,"asset_id":87689868,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91831164/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689868"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689868"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689868; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689867"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87689867/The_effect_of_high_maternal_linoleic_acid_on_endocannabinoid_signalling_in_rodent_hearts"><img alt="Research paper thumbnail of The effect of high maternal linoleic acid on endocannabinoid signalling in rodent hearts" class="work-thumbnail" src="https://attachments.academia-assets.com/91831207/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87689867/The_effect_of_high_maternal_linoleic_acid_on_endocannabinoid_signalling_in_rodent_hearts">The effect of high maternal linoleic acid on endocannabinoid signalling in rodent hearts</a></div><div class="wp-workCard_item"><span>Journal of Developmental Origins of Health and Disease</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The endocannabinoid system (ECS), modulated by metabolites of linoleic acid (LA), is important in...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The endocannabinoid system (ECS), modulated by metabolites of linoleic acid (LA), is important in regulating cardiovascular function. In pregnancy, LA is vital for foetal development. We investigated the effects of elevated LA in H9c2 cardiomyoblasts in vitro and of a high linoleic acid (HLA, 6.21%) or low linoleic acid (LLA, 1.44%) diet during pregnancy in maternal and offspring hearts. H9c2 cell viability was reduced following LA exposure at concentrations between 300 and 1000 µM. HLA diet decreased cannabinoid receptor type 2 (CB2) mRNA expression in foetal hearts from both sexes. However, HLA diet increased CB2 expression in maternal hearts. The mRNA expression of fatty acid amide hydrolase (FAAH) in foetal hearts was higher in females than in males irrespective of diet and N-acyl phosphatidylethanolamine-specific phospholipase D (NAPE-PLD) mRNA expression showed an interaction between diet and sex. Data indicate that a high LA diet alters cell viability and CB2 expression, pote...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cc3a3d3cc1b3d1b1fe77946152aaf587" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91831207,"asset_id":87689867,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91831207/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689867"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689867"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689867; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689866"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87689866/Peripheral_modulation_of_the_endocannabinoid_system_in_metabolic_disease"><img alt="Research paper thumbnail of Peripheral modulation of the endocannabinoid system in metabolic disease" class="work-thumbnail" src="https://attachments.academia-assets.com/91831199/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87689866/Peripheral_modulation_of_the_endocannabinoid_system_in_metabolic_disease">Peripheral modulation of the endocannabinoid system in metabolic disease</a></div><div class="wp-workCard_item"><span>Drug Discovery Today</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Highlights:  The endocannabinoid system (ECS) is dysregulated in obesity-associated diseases  C...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Highlights:  The endocannabinoid system (ECS) is dysregulated in obesity-associated diseases  CB1 antagonism is a potential therapeutic target for the treatment of obesity  CB1 antagonists have the potential for eliciting severe psychiatric side effects  Antagonists of CB1 that do not cross the blood-brain barrier are in development  Peripherally restricted CB1 antagonists are novel therapeutic targets for obesity Teaser: This Keynote review discusses the peripheral modulation of the ECS in liver, adipose tissue, heart, skeletal muscle, gastrointestinal tract, pancreas, kidney and the immunoinflammatory system. Dysfunction of the endocannabinoid system (ECS) has been identified in metabolic disease. Cannabinoid receptor 1 (CB1) is abundantly expressed in the brain but also expressed in the periphery. Cannabinoid receptor 2 (CB2) is more abundant in the periphery, including the immune cells. In obesity, global antagonism of overexpressed CB1 reduces bodyweight but leads to centrally mediated adverse psychological outcomes. Emerging research in isolated cultured cells or tissues has demonstrated that targeting the endocannabinoid system in the periphery alleviates the pathologies associated with metabolic disease. Further, peripheral specific cannabinoid ligands can reverse aspects of the metabolic phenotype. This Keynote review will focus on current research on the functionality of peripheral modulation of the ECS for the treatment of obesity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1d03708af243e3fc5670e154b03c6bbe" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91831199,"asset_id":87689866,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91831199/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689866"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689866"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689866; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87689866]").text(description); $(".js-view-count[data-work-id=87689866]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87689866; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87689866']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1d03708af243e3fc5670e154b03c6bbe" } } $('.js-work-strip[data-work-id=87689866]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87689866,"title":"Peripheral modulation of the endocannabinoid system in metabolic disease","internal_url":"https://www.academia.edu/87689866/Peripheral_modulation_of_the_endocannabinoid_system_in_metabolic_disease","owner_id":24453968,"coauthors_can_edit":true,"owner":{"id":24453968,"first_name":"Nirajan","middle_initials":null,"last_name":"Shrestha, PhD","page_name":"NirajanShrestha","domain_name":"massgeneral","created_at":"2015-01-06T20:06:09.191-08:00","display_name":"Nirajan Shrestha, PhD","url":"https://massgeneral.academia.edu/NirajanShrestha"},"attachments":[{"id":91831199,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/91831199/thumbnails/1.jpg","file_name":"ShresthaPUB4805.pdf","download_url":"https://www.academia.edu/attachments/91831199/download_file","bulk_download_file_name":"Peripheral_modulation_of_the_endocannabi.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/91831199/ShresthaPUB4805-libre.pdf?1664653298=\u0026response-content-disposition=attachment%3B+filename%3DPeripheral_modulation_of_the_endocannabi.pdf\u0026Expires=1739924163\u0026Signature=fvG8HhLcS7OQbwCoto6nsCulYQWMJ7jRib9d-OSf~zs-cLn2nST5GJ25BmmR0Yp2GGMchYTNZeCc30Ox5jnr3wr42aYpepM2~5xF14ZacvJIvPTutdC2sUXBSqbqJPxSHe7G-zlrv7sgv4q6k4Nb-lAqrYC2yuhCNK8DC9LYdP3B1b6EJzkLoJG2uze~uz-rJd9Xta3shjROm8tK-dkgCtS~9hZ~Nbyd3vMCWj6UzO-C~RTSdMCyrw4YSTw1ZJVT6247iKtaecXnpScOTClFHLO7xsVI3Gqp7JzO7dkLPNqlWN538s-sJHuiwGRYkP1RqsqWtId0yrVC7us-g6SO4A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689865"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87689865/The_fate_of_hepatocyte_cell_line_derived_from_a_liver_injury_model_with_long_term_in_vitro_passage"><img alt="Research paper thumbnail of The fate of hepatocyte cell line derived from a liver injury model with long-term in vitro passage" class="work-thumbnail" src="https://attachments.academia-assets.com/91831204/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87689865/The_fate_of_hepatocyte_cell_line_derived_from_a_liver_injury_model_with_long_term_in_vitro_passage">The fate of hepatocyte cell line derived from a liver injury model with long-term in vitro passage</a></div><div class="wp-workCard_item"><span>Molecular & Cellular Toxicology</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Backgrounds: orthotopic liver Transplantation (olT) is the therapy of choice for the treatment of...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Backgrounds: orthotopic liver Transplantation (olT) is the therapy of choice for the treatment of end-stage liver disease, but the severe shortage of organ donors, complex and expensive surgical procedure and increased mortality of prospective organ recipient limit the use of olT. To overcome this problem the technique of hepatocyte transplantation has been considered as an alternative to olT. Hepatocyte transplantation is less invasive, cost effective cryo-preservable and can be distributed from single donor to multiple recipients. in this study we have established and characterize the hepatocyte cell line possessing the morphological and functional characteristics of hepatocytes from chemically injured liver. Hence we hypothesized that the hepatocyte cell line derived from liver injury can be used for hepatocyte transplantation. Methods: To induce the priming of hepatocyte, mice were fed with 3,5-diethoxycarbonyl-1,4-dihydro-collidine (DDC) diet for 3 weeks and hepatocytes were obtained by two step collagenase perfusion method, hepatocytes hence obtained was expended by >300 passages and tested for various hepatocyte specific functions. Results: The cell line derived from liver injury model retains morphological and functional characteristics of hepatocytes in long-term in vitro culture. These cells transplanted to mice showed significant survival rate. Conclusion: The Hepatocyte cell line derived from liver injury model were used for hepatocyte transplantation and showed the significantly higher survival rate.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="36ea3b81118835ce7cb5061c16aa3e1a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91831204,"asset_id":87689865,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91831204/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689865"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689865"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689865; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="11078139" id="papers"><div class="js-work-strip profile--work_container" data-work-id="103486046"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/103486046/Changes_in_Essential_Fatty_Acids_and_Ileal_Genes_Associated_with_Metabolizing_Enzymes_and_Fatty_Acid_Transporters_in_Rodent_Models_of_Cystic_Fibrosis"><img alt="Research paper thumbnail of Changes in Essential Fatty Acids and Ileal Genes Associated with Metabolizing Enzymes and Fatty Acid Transporters in Rodent Models of Cystic Fibrosis" class="work-thumbnail" src="https://attachments.academia-assets.com/103480790/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/103486046/Changes_in_Essential_Fatty_Acids_and_Ileal_Genes_Associated_with_Metabolizing_Enzymes_and_Fatty_Acid_Transporters_in_Rodent_Models_of_Cystic_Fibrosis">Changes in Essential Fatty Acids and Ileal Genes Associated with Metabolizing Enzymes and Fatty Acid Transporters in Rodent Models of Cystic Fibrosis</a></div><div class="wp-workCard_item"><span>International Journal of Molecular Sciences</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Cystic fibrosis (CF), the result of mutations in the CF transmembrane conductance regulator (CFTR...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Cystic fibrosis (CF), the result of mutations in the CF transmembrane conductance regulator (CFTR), causes essential fatty acid deficiency. The aim of this study was to characterize fatty acid handling in two rodent models of CF; one strain which harbors the loss of phenylalanine at position 508 (Phe508del) in CFTR and the other lacks functional CFTR (510X). Fatty acid concentrations were determined using gas chromatography in serum from Phe508del and 510X rats. The relative expression of genes responsible for fatty acid transport and metabolism were quantified using real-time PCR. Ileal tissue morphology was assessed histologically. There was an age-dependent decrease in eicosapentaenoic acid and the linoleic acid:α-linolenic acid ratio, a genotype-dependent decrease in docosapentaenoic acid (n-3) and an increase in the arachidonic acid:docosahexaenoic acid ratio in Phe508del rat serum, which was not observed in 510X rats. In the ileum, Cftr mRNA was increased in Phe508del rats but...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="bd34e161775b5efee7495a642566d5bb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":103480790,"asset_id":103486046,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/103480790/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="103486046"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="103486046"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 103486046; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=103486046]").text(description); $(".js-view-count[data-work-id=103486046]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 103486046; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='103486046']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="103486045"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/103486045/Essential_Fatty_Acid_Deficiency_in_Cystic_Fibrosis_Disease_Progression_Role_of_Genotype_and_Sex"><img alt="Research paper thumbnail of Essential Fatty Acid Deficiency in Cystic Fibrosis Disease Progression: Role of Genotype and Sex" class="work-thumbnail" src="https://attachments.academia-assets.com/103480789/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/103486045/Essential_Fatty_Acid_Deficiency_in_Cystic_Fibrosis_Disease_Progression_Role_of_Genotype_and_Sex">Essential Fatty Acid Deficiency in Cystic Fibrosis Disease Progression: Role of Genotype and Sex</a></div><div class="wp-workCard_item"><span>Nutrients</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Adequate intake of nutrients such as essential fatty acids (EFA) are critical in cystic fibrosis ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Adequate intake of nutrients such as essential fatty acids (EFA) are critical in cystic fibrosis (CF). The clinical course of deterioration of lung function in people with CF has been shown to relate to nutrition. Independent of the higher energy consumption and malabsorption due to pancreatic insufficiency, EFA deficiency is closely associated with the risk of pulmonary infection, the most significant pathology in CF. This review will focus on the EFA deficiency identified in people with CF, as well as the limited progress made in deciphering the exact metabolic pathways that are dysfunctional in CF. Specifically, people with CF are deficient in linoleic acid, an omega 6 fatty acid, and the ratio of arachidonic acid (omega 6 metabolite) and docosahexaenoic acid (omega 3 metabolite) is increased. Analysis of the molecular pathways in bronchial cells has identified changes in the enzymes that metabolise EFA. However, fatty acid metabolism primarily occurs in the liver, with EFA metab...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2f365ef5ff92fd7f569b3b423796b8ff" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":103480789,"asset_id":103486045,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/103480789/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="103486045"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="103486045"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 103486045; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=103486045]").text(description); $(".js-view-count[data-work-id=103486045]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 103486045; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='103486045']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689883"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87689883/PE_149_Association_of_Serum_Aminotransferases_with_High_Density_Lipoprotein_Cholesterol_HDL_C_in_Diabetic_Patients"><img alt="Research paper thumbnail of PE-149: Association of Serum Aminotransferases with High Density Lipoprotein Cholesterol (HDL-C) in Diabetic Patients" class="work-thumbnail" src="https://attachments.academia-assets.com/91831171/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87689883/PE_149_Association_of_Serum_Aminotransferases_with_High_Density_Lipoprotein_Cholesterol_HDL_C_in_Diabetic_Patients">PE-149: Association of Serum Aminotransferases with High Density Lipoprotein Cholesterol (HDL-C) in Diabetic Patients</a></div><div class="wp-workCard_item"><span>춘·추계 학술대회 (KASL)</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Conclusions: NAFLD is associated with changes in biochemical parameters in cases of NAFLD. Its ea...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Conclusions: NAFLD is associated with changes in biochemical parameters in cases of NAFLD. Its early detection will help in modifying the disease course, delaying complications and will also play a major role in preventive cardiology.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6a717f7a8df47821578b67a767e80d27" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91831171,"asset_id":87689883,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91831171/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689883"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689883"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689883; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689882"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/87689882/Maternal_and_postnatal_diet_high_in_linoleic_acid_alters_fatty_acid_composition_cholesterol_and_hepatic_gene_expression_in_adult_offspring_in_a_sex_specific_manner"><img alt="Research paper thumbnail of Maternal and postnatal diet high in linoleic acid alters fatty acid composition, cholesterol and hepatic gene expression, in adult offspring in a sex‐specific manner" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/87689882/Maternal_and_postnatal_diet_high_in_linoleic_acid_alters_fatty_acid_composition_cholesterol_and_hepatic_gene_expression_in_adult_offspring_in_a_sex_specific_manner">Maternal and postnatal diet high in linoleic acid alters fatty acid composition, cholesterol and hepatic gene expression, in adult offspring in a sex‐specific manner</a></div><div class="wp-workCard_item"><span>The FASEB Journal</span><span>, 2021</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689882"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689882"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689882; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87689882]").text(description); $(".js-view-count[data-work-id=87689882]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87689882; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87689882']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689881"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87689881/PE_148_Waist_Circumference_Not_Body_Mass_Index_Is_Associated_with_Increased_Gamma_glutamyltranspeptidase_in_Type_Diabetes_Mellitus"><img alt="Research paper thumbnail of PE-148: Waist Circumference, Not Body Mass Index, Is Associated with Increased Gamma-glutamyltranspeptidase in Type Diabetes Mellitus" class="work-thumbnail" src="https://attachments.academia-assets.com/91831211/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87689881/PE_148_Waist_Circumference_Not_Body_Mass_Index_Is_Associated_with_Increased_Gamma_glutamyltranspeptidase_in_Type_Diabetes_Mellitus">PE-148: Waist Circumference, Not Body Mass Index, Is Associated with Increased Gamma-glutamyltranspeptidase in Type Diabetes Mellitus</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Aims: Serum gamma-glutamyltranspeptidase ( GGT), a marker of liver injury, alcohol consumption, a...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Aims: Serum gamma-glutamyltranspeptidase ( GGT), a marker of liver injury, alcohol consumption, and oxidative stress, has been shown to be associated with obesity and diabetes mellitus. Obese individuals with higher GGT are associated with complications in type 2 diabetic patients. There is evidence that waist circumference (WC) measured obesity more accurately than body mass index (BMI). In the present study, we aimed to evaluate association of GGT with WC and BMI in diabetic subjects. Methods: The study subjects were 105 type 2 diabetic patients (39 men and 66 women), who attended outpatient department of Nepal Medical College Teaching Hospital, Kathmandu, Nepal. The patients with the history of alcohol intake and liver disease were excluded from the study. Anthropometric measurement was taken and venous blood was collected for biochemical analysis. Statistical analysis was done using SPSS 16.0. The p-values less than 0.05 were considered as significant. Results: The serum GGT lev...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a0db354fd2d9ee4c57082040d024d0f3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91831211,"asset_id":87689881,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91831211/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689881"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689881"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689881; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689880"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/87689880/Role_of_High_Maternal_Linoleic_Acid_on_Offspring_Health"><img alt="Research paper thumbnail of Role of High Maternal Linoleic Acid on Offspring Health" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/87689880/Role_of_High_Maternal_Linoleic_Acid_on_Offspring_Health">Role of High Maternal Linoleic Acid on Offspring Health</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Maternal nutrition during pregnancy plays a critical role in the adult-onset of disease in a moth...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Maternal nutrition during pregnancy plays a critical role in the adult-onset of disease in a mother’s children. The first 1000 days, spanning from conception to two years of life, are an important period when appropriate nutritional needs must be ensured for long-term health. Studies have shown that inadequate nutritional condition in utero and early life increases the risk of developing chronic conditions later in life. In recent years, the intake of linoleic acid (LA) has increased gradually in human populations, due to changes in a dietary pattern that have resulted in increased consumption of vegetable oils and foods processed in vegetable oils. LA is an omega-6 polyunsaturated fatty acid (n-6 PUFA), which is an essential fatty acid required in the human diet. LA plays a vital role in fetal growth and development. Even though LA is essential in our diet, studies have raised concern over its beneficial effect, as excess LA is shown to have pro-inflammatory characteristics. In add...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689880"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689880"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689880; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87689880]").text(description); $(".js-view-count[data-work-id=87689880]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87689880; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87689880']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=87689880]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87689880,"title":"Role of High Maternal Linoleic Acid on Offspring Health","internal_url":"https://www.academia.edu/87689880/Role_of_High_Maternal_Linoleic_Acid_on_Offspring_Health","owner_id":24453968,"coauthors_can_edit":true,"owner":{"id":24453968,"first_name":"Nirajan","middle_initials":null,"last_name":"Shrestha, PhD","page_name":"NirajanShrestha","domain_name":"massgeneral","created_at":"2015-01-06T20:06:09.191-08:00","display_name":"Nirajan Shrestha, PhD","url":"https://massgeneral.academia.edu/NirajanShrestha"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689879"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/87689879/Role_for_animal_models_in_understanding_essential_fatty_acid_deficiency_in_cystic_fibrosis"><img alt="Research paper thumbnail of Role for animal models in understanding essential fatty acid deficiency in cystic fibrosis" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/87689879/Role_for_animal_models_in_understanding_essential_fatty_acid_deficiency_in_cystic_fibrosis">Role for animal models in understanding essential fatty acid deficiency in cystic fibrosis</a></div><div class="wp-workCard_item"><span>Cellular and Molecular Life Sciences</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Essential fatty acid deficiency has been observed in most patients with Cystic Fibrosis (CF); how...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Essential fatty acid deficiency has been observed in most patients with Cystic Fibrosis (CF); however, pancreatic supplementation does not restore the deficiency, suggesting a different pathology independent of the pancreas. At this time, the underlying pathological mechanisms are largely unknown. Essential fatty acids are obtained from the diet and processed by organs including the liver and intestine, two organs significantly impacted by mutations in the cystic fibrosis transmembrane conductance regulator gene (Cftr). There are several CF animal models in a variety of species that have been developed to investigate molecular mechanisms associated with the CF phenotype. Specifically, global and systemic mutations in Cftr which mimic genotypic changes identified in CF patients have been generated in mice, rats, sheep, pigs and ferrets. These mutations produce CFTR proteins with a gating defect, trafficking defect, or an absent or inactive CFTR channel. Essential fatty acids are critical to CFTR function, with a bidirectional relationship between CFTR and essential fatty acids proposed. Currently, there are limited analyses on the essential fatty acid status in most of these animal models. Of interest, in the mouse model, essential fatty acid status is dependent on the genotype and resultant phenotype of the mouse. Future investigations should identify an optimal animal model that has most of the phenotypic changes associated with CF including the essential fatty acid deficiencies, which can be used in the development of therapeutics.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689879"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689879"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689879; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); 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</script> <div class="js-work-strip profile--work_container" data-work-id="87689878"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87689878/Sex_Specific_Differences_in_Lysine_3_Hydroxybutyric_Acid_and_Acetic_Acid_in_Offspring_Exposed_to_Maternal_and_Postnatal_High_Linoleic_Acid_Diet_Independent_of_Diet"><img alt="Research paper thumbnail of Sex-Specific Differences in Lysine, 3-Hydroxybutyric Acid and Acetic Acid in Offspring Exposed to Maternal and Postnatal High Linoleic Acid Diet, Independent of Diet" class="work-thumbnail" src="https://attachments.academia-assets.com/91831169/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87689878/Sex_Specific_Differences_in_Lysine_3_Hydroxybutyric_Acid_and_Acetic_Acid_in_Offspring_Exposed_to_Maternal_and_Postnatal_High_Linoleic_Acid_Diet_Independent_of_Diet">Sex-Specific Differences in Lysine, 3-Hydroxybutyric Acid and Acetic Acid in Offspring Exposed to Maternal and Postnatal High Linoleic Acid Diet, Independent of Diet</a></div><div class="wp-workCard_item"><span>International Journal of Molecular Sciences</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Background: Linoleic acid (LA) is an essential polyunsaturated fatty acid (PUFA) that is required...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Background: Linoleic acid (LA) is an essential polyunsaturated fatty acid (PUFA) that is required for foetal growth and development. Excess intake of LA can be detrimental for metabolic health due to its pro-inflammatory properties; however, the effect of a diet high in LA on offspring metabolites is unknown. In this study, we aimed to determine the role of maternal or postnatal high linoleic acid (HLA) diet on plasma metabolites in adult offspring. Methods: Female Wistar Kyoto (WKY) rats were fed with either low LA (LLA) or HLA diet for 10 weeks prior to conception and during gestation/lactation. Offspring were weaned at postnatal day 25 (PN25), treated with either LLA or HLA diets and sacrificed at PN180. Metabolite analysis was performed in plasma samples using Nuclear Magnetic Resonance. Results: Maternal and postnatal HLA diet did not alter plasma metabolites in male and female adult offspring. There was no specific clustering among different treatment groups as demonstrated by...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="97209b05bb67acc8cf9df9c485f23bd1" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91831169,"asset_id":87689878,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91831169/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689878"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689878"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689878; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689877"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87689877/Maternal_diet_high_in_linoleic_acid_alters_offspring_fatty_acids_and_cardiovascular_function_in_a_rat_model"><img alt="Research paper thumbnail of Maternal diet high in linoleic acid alters offspring fatty acids and cardiovascular function in a rat model" class="work-thumbnail" src="https://attachments.academia-assets.com/91831208/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87689877/Maternal_diet_high_in_linoleic_acid_alters_offspring_fatty_acids_and_cardiovascular_function_in_a_rat_model">Maternal diet high in linoleic acid alters offspring fatty acids and cardiovascular function in a rat model</a></div><div class="wp-workCard_item"><span>British Journal of Nutrition</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Linoleic acid (LA), an essential n-6 fatty acid (FA), is critical for fetal development. We inves...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Linoleic acid (LA), an essential n-6 fatty acid (FA), is critical for fetal development. We investigated the effects of maternal high LA (HLA) diet on offspring cardiac development and its relationship to circulating FA and cardiovascular function in adolescent offspring, and the ability of the postnatal diet to reverse any adverse effects. Female Wistar Kyoto rats were fed low LA (LLA; 1·44 % energy from LA) or high LA (HLA; 6·21 % energy from LA) diets for 10 weeks before pregnancy and during gestation/lactation. Offspring, weaned at postnatal day 25, were fed LLA or HLA diets and euthanised at postnatal day 40 (n 6–8). Maternal HLA diet decreased circulating total cholesterol and HDL-cholesterol in females and decreased total plasma n-3 FA in males, while maternal and postnatal HLA diets decreased total plasma n-3 FA in females. α-Linolenic acid (ALA) and EPA were decreased by postnatal but not maternal HLA diets in both sexes. Maternal and postnatal HLA diets increased total pla...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9a0110dbf7609ab8d67fbff0fbb0b997" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91831208,"asset_id":87689877,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91831208/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689877"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689877"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689877; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689876"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87689876/Developmental_programming_of_peripheral_diseases_in_offspring_exposed_to_maternal_obesity_during_pregnancy"><img alt="Research paper thumbnail of Developmental programming of peripheral diseases in offspring exposed to maternal obesity during pregnancy" class="work-thumbnail" src="https://attachments.academia-assets.com/91831163/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87689876/Developmental_programming_of_peripheral_diseases_in_offspring_exposed_to_maternal_obesity_during_pregnancy">Developmental programming of peripheral diseases in offspring exposed to maternal obesity during pregnancy</a></div><div class="wp-workCard_item"><span>American Journal of Physiology-Regulatory, Integrative and Comparative Physiology</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Obesity is an increasing global health epidemic that affects all ages, including women of reprodu...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Obesity is an increasing global health epidemic that affects all ages, including women of reproductive age. During pregnancy, maternal obesity is associated with adverse pregnancy outcomes that lead to complications for the mother. In addition, maternal obesity can increase the risk of poor perinatal outcomes for the infant due to altered development. Recent research has investigated the effects of maternal obesity on peripheral organ development and health in later life in offspring. In this review, we have summarized studies that investigated the programming effects of maternal obesity before and during pregnancy on metabolic, cardiovascular, immune, and microbiome perturbations in offspring. Epidemiological studies investigating the effects of maternal obesity on offspring development can be complex due to other copathologies and genetic diversity. Animal studies have provided some insights into the specific mechanisms and pathways involved in programming peripheral disease risk....</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="af4557e956b673be4abdad7e823eb158" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91831163,"asset_id":87689876,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91831163/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689876"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689876"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689876; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689874"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87689874/Maternal_and_Postnatal_High_Linoleic_Acid_Diet_Impacts_Lipid_Metabolism_in_Adult_Rat_Offspring_in_a_Sex_Specific_Manner"><img alt="Research paper thumbnail of Maternal and Postnatal High Linoleic Acid Diet Impacts Lipid Metabolism in Adult Rat Offspring in a Sex-Specific Manner" class="work-thumbnail" src="https://attachments.academia-assets.com/91831162/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87689874/Maternal_and_Postnatal_High_Linoleic_Acid_Diet_Impacts_Lipid_Metabolism_in_Adult_Rat_Offspring_in_a_Sex_Specific_Manner">Maternal and Postnatal High Linoleic Acid Diet Impacts Lipid Metabolism in Adult Rat Offspring in a Sex-Specific Manner</a></div><div class="wp-workCard_item"><span>International Journal of Molecular Sciences</span><span>, 2021</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Linoleic acid (LA), an n-6 polyunsaturated fatty acid (PUFA), is essential for fetal growth and d...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Linoleic acid (LA), an n-6 polyunsaturated fatty acid (PUFA), is essential for fetal growth and development. We aimed to investigate the effect of maternal and postnatal high LA (HLA) diet on plasma FA composition, plasma and hepatic lipids and genes involved in lipid metabolism in the liver of adult offspring. Female rats were fed with low LA (LLA; 1.44% LA) or HLA (6.21% LA) diets for 10 weeks before pregnancy, and during gestation/lactation. Offspring were weaned at postnatal day 25 (PN25), fed either LLA or HLA diets and sacrificed at PN180. Postnatal HLA diet decreased circulating total n-3 PUFA and alpha-linolenic acid (ALA), while increased total n-6 PUFA, LA and arachidonic acid (AA) in both male and female offspring. Maternal HLA diet increased circulating leptin in female offspring, but not in males. Maternal HLA diet decreased circulating adiponectin in males. Postnatal HLA diet significantly decreased aspartate transaminase (AST) in females and downregulated total choles...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="eb64ac68a8986d3881b711036feef20e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91831162,"asset_id":87689874,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91831162/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689874"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689874"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689874; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689873"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87689873/Role_for_endocannabinoids_in_early_pregnancy_recent_advances_and_the_effects_of_cannabis_use"><img alt="Research paper thumbnail of Role for endocannabinoids in early pregnancy: recent advances and the effects of cannabis use" class="work-thumbnail" src="https://attachments.academia-assets.com/91831160/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87689873/Role_for_endocannabinoids_in_early_pregnancy_recent_advances_and_the_effects_of_cannabis_use">Role for endocannabinoids in early pregnancy: recent advances and the effects of cannabis use</a></div><div class="wp-workCard_item"><span>American Journal of Physiology-Endocrinology and Metabolism</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The endocannabinoid system (ECS) is associated with several physiological processes, including re...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The endocannabinoid system (ECS) is associated with several physiological processes, including reproduction. This system consists of the cannabinoid receptors, endocannabinoid ligands, and enzymes that metabolize and degrade these fatty acids. Recent evidence shows that cannabinoid receptors are expressed in cells of the reproductive system, including endometrial stromal cells, ovaries, and sperm cells. Emerging and recent research suggests that the ECS may play a significant role in reproduction. The endocannabinoid ligands anandamide and 2-arachidonoylglycerol are crucial for successful endometrium decidualization, placental development, and embryo implantation. Alteration in cannabinoid receptor expression or in endocannabinoid homeostasis by excessive intake of cannabis during pregnancy is associated with negative pregnancy outcomes, including preterm birth. The use of medicinal cannabis is becoming more widespread in Western countries, especially in people of reproductive age. ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4535eef5147a7dafd6764b47e1de902e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91831160,"asset_id":87689873,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91831160/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689873"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689873"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689873; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689872"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/87689872/Elevated_maternal_linoleic_acid_alters_placental_fatty_acids_nutrient_transporters_and_inflammatory_proteins"><img alt="Research paper thumbnail of Elevated maternal linoleic acid alters placental fatty acids, nutrient transporters and inflammatory proteins" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/87689872/Elevated_maternal_linoleic_acid_alters_placental_fatty_acids_nutrient_transporters_and_inflammatory_proteins">Elevated maternal linoleic acid alters placental fatty acids, nutrient transporters and inflammatory proteins</a></div><div class="wp-workCard_item"><span>The FASEB Journal</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Linoleic acid (LA) is the major omega‐6 fatty acid which is obtained from our diet. During pregna...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Linoleic acid (LA) is the major omega‐6 fatty acid which is obtained from our diet. During pregnancy, LA is required for adequate fetal growth and development. For the growing fetus LA can only be obtained from the maternal diet, and is transferred from the maternal to fetal circulations by the placenta. At this time, in Western societies, we are overconsuming LA during pregnancy. Omega‐6 is metabolised by FADS1 and FADS2, which also metabiolise omega‐3. The ratio of omega‐6 to omega‐3 is important for human health, as they are proinflammatory and anti‐inflammatory, respectively. Therefore, the aim of this study is to determine if elevated maternal LA during pregnancy is alters placental fatty acids, nutrient transporter gene expression and inflammatory proteins. Female Wistar Kyoto rats were fed a diet low in LA (LLA‐1.44% of energy) or diet high in LA (HLA‐6.21% of energy) for 10 weeks before and during gestation. Following mating with a male consuming normal chow, offspring and maternal rats were sacrificed at embryonic day (E)20, and placenta were collected for analysis of placental fatty acids, nutrient transporters and inflammatory markers. In isolated placenta from pregnancies where mothers consumed an elevated LA diet, the concentration of LA was increased and the concentration of the omega‐3 fatty acid a‐linoleinic acid was decreased. Of interest, the downstream metabolite of LA, arachidonic acid was not altered in placenta from mothers consuming an elevated LA diet. mRNA expression of slc27a1 (fatty acid trasnport protein 1) was significantly downregulated in the male placenta from the dams fed with HLA, but not females. The mRNA expression of slc2a1 (glucose trasnporter 1) was significantly decreased in both male and female placenta from mothers fed the HLA diet. Further, the protein concentration of interleukin‐7 (IL‐7) was significantly decreased in both male and female placenta (labyrinth) from the dams fed with HLA, however there were no changes in protein expression of IL‐6 and TNF‐α in the labyrinth. In conclusion, a maternal diet high in LA alters fatty acid concentrations, nutrient transporters and inflammatory cytokines in the placenta. The consequences of this on offspring development, and therefore long term health require further investigation.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689872"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689872"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689872; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87689872]").text(description); $(".js-view-count[data-work-id=87689872]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87689872; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87689872']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=87689872]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87689872,"title":"Elevated maternal linoleic acid alters placental fatty acids, nutrient transporters and inflammatory proteins","internal_url":"https://www.academia.edu/87689872/Elevated_maternal_linoleic_acid_alters_placental_fatty_acids_nutrient_transporters_and_inflammatory_proteins","owner_id":24453968,"coauthors_can_edit":true,"owner":{"id":24453968,"first_name":"Nirajan","middle_initials":null,"last_name":"Shrestha, PhD","page_name":"NirajanShrestha","domain_name":"massgeneral","created_at":"2015-01-06T20:06:09.191-08:00","display_name":"Nirajan Shrestha, PhD","url":"https://massgeneral.academia.edu/NirajanShrestha"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689871"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87689871/Maternal_High_Linoleic_Acid_Alters_Placental_Fatty_Acid_Composition"><img alt="Research paper thumbnail of Maternal High Linoleic Acid Alters Placental Fatty Acid Composition" class="work-thumbnail" src="https://attachments.academia-assets.com/91831154/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87689871/Maternal_High_Linoleic_Acid_Alters_Placental_Fatty_Acid_Composition">Maternal High Linoleic Acid Alters Placental Fatty Acid Composition</a></div><div class="wp-workCard_item"><span>Nutrients</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Fetal development is modulated by maternal nutrition during pregnancy. The dietary intake of lino...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Fetal development is modulated by maternal nutrition during pregnancy. The dietary intake of linoleic acid (LA), an essential dietary n-6 polyunsaturated fatty acid (PUFA), has increased. We previously published that increased LA consumption during pregnancy does not alter offspring or placental weight but fetal plasma fatty acid composition; the developing fetus obtains their required PUFA from the maternal circulation. However, it is unknown if increased maternal linoleic acid alters placental fatty acid storage, metabolism, transport, and general placental function. Female Wistar-Kyoto rats were fed either a low LA diet (LLA; 1.44% of energy from LA) or high LA diet (HLA; 6.21% of energy from LA) for 10 weeks before pregnancy and during gestation. Rats were sacrificed at embryonic day 20 (E20, term = 22 days) and placentae collected. The labyrinth of placentae from one male and one female fetus from each litter were analyzed. High maternal LA consumption increased placental total...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1152657ed71476bcd276ce7f84d7b06d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91831154,"asset_id":87689871,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91831154/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689871"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689871"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689871; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87689871]").text(description); $(".js-view-count[data-work-id=87689871]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87689871; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87689871']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689870"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/87689870/Role_of_a_Maternal_Diet_High_in_Linoleic_Acid_on_the_Plasma_Fatty_Acid_Composition_in_Rat_Offspring"><img alt="Research paper thumbnail of Role of a Maternal Diet High in Linoleic Acid on the Plasma Fatty Acid Composition in Rat Offspring" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/87689870/Role_of_a_Maternal_Diet_High_in_Linoleic_Acid_on_the_Plasma_Fatty_Acid_Composition_in_Rat_Offspring">Role of a Maternal Diet High in Linoleic Acid on the Plasma Fatty Acid Composition in Rat Offspring</a></div><div class="wp-workCard_item"><span>The FASEB Journal</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Linoleic acid (LA) is a major omega‐6 polyunsaturated fatty acid (PUFA) which is essential in our...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Linoleic acid (LA) is a major omega‐6 polyunsaturated fatty acid (PUFA) which is essential in our diet. LA is an important fatty acid for fetal growth and development and is transported from mother to fetus through the placenta. Dietary intake of LA has increased significantly in western societies primarily due to increased consumption of vegetable oils. Conversely, the consumption of alpha‐linolenic acid (ALA), an omega‐3 PUFA, has remained similar or decreased due to limited consumption of fish. Metabolites of omega‐3 PUFAs such as docosahexaenoic (DHA) and eicosapentaenoic (EPA) have critical roles in fetal neural development and may influence brain function in later in life. The aim of this study is to investigate the effect of a maternal diet high in LA on offspring fatty acid composition at 40 days of age (adolescence). Female rats were fed with either low LA diet (LLA; 1.44% of energy from LA) or high LA (HLA; 6.21% of energy from LA) with matched ALA (0.3% of energy) for 10 weeks before pregnancy and during gestation. The pups were weaned at postnatal day 25 (PN25) and fed with either LLA or HLA diet (Four groups ‐ LL, LH, HL, HH; first letter denotes maternal diet and second letter denotes post‐weaning diet). The offspring were sacrificed at postnatal day 40 and biological samples were collected and stored at −80°C. The concentration of fatty acids in plasma was quantified using gas chromatography. Total omega‐6 fatty acid (FA) and LA levels in plasma were significantly elevated in the offspring fed with HLA diet at weaning and offspring from dams fed with HLA (LH, HL, HH) compared to offspring from LLA dams fed with LLA at weaning (LL) both in male and female offspring. Total omega‐3 FA was significantly decreased in offspring from HLA dams fed with HLA diet (HH) at weaning in comparison to offspring from LLA dams fed with LLA at weaning (LL). The concentration of ALA was significantly decreased in male offspring from HLA dams fed with HLA diet (HH) compared to HL offspring; however, there was no difference in female offspring. In addition, the plasma level of EPA was significantly decreased in male offspring fed with HLA diet at weaning (LH and HH) compared with LL offspring; however, there was no difference in female offspring. Moreover, DHA, an important omega‐3 FA for brain development, was significantly decreased in HH offspring compared to LL offspring. Hence, the findings from the current study suggest that elevated LA in both maternal diet and weaning diet influence the plasma fatty acid composition in adolescent offspring in a rat model.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689870"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689870"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689870; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=87689870]").text(description); $(".js-view-count[data-work-id=87689870]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 87689870; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='87689870']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-a9bf3a2bc8c89fa2a77156577594264ee8a0f214d74241bc0fcd3f69f8d107ac.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=87689870]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":87689870,"title":"Role of a Maternal Diet High in Linoleic Acid on the Plasma Fatty Acid Composition in Rat Offspring","internal_url":"https://www.academia.edu/87689870/Role_of_a_Maternal_Diet_High_in_Linoleic_Acid_on_the_Plasma_Fatty_Acid_Composition_in_Rat_Offspring","owner_id":24453968,"coauthors_can_edit":true,"owner":{"id":24453968,"first_name":"Nirajan","middle_initials":null,"last_name":"Shrestha, PhD","page_name":"NirajanShrestha","domain_name":"massgeneral","created_at":"2015-01-06T20:06:09.191-08:00","display_name":"Nirajan Shrestha, PhD","url":"https://massgeneral.academia.edu/NirajanShrestha"},"attachments":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689869"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87689869/Role_of_omega_6_and_omega_3_fatty_acids_in_fetal_programming"><img alt="Research paper thumbnail of Role of omega‐6 and omega‐3 fatty acids in fetal programming" class="work-thumbnail" src="https://attachments.academia-assets.com/91831209/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87689869/Role_of_omega_6_and_omega_3_fatty_acids_in_fetal_programming">Role of omega‐6 and omega‐3 fatty acids in fetal programming</a></div><div class="wp-workCard_item"><span>Clinical and Experimental Pharmacology and Physiology</span><span>, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Maternal nutrition plays a critical role in fetal development and can influence adult onset of di...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Maternal nutrition plays a critical role in fetal development and can influence adult onset of disease. Linoleic acid (LA) and alpha-linolenic acid (ALA) are major omega-6 (n-6) and n-3 polyunsaturated fatty acids (PUFA), respectively, that are essential in our diet. LA and ALA are critical for the development of the fetal neurological and immune systems. However, in recent years, the consumption of n-6 PUFA has increased gradually worldwide, and elevated n-6 PUFA consumption may be harmful to human health. Consumption of diets with high levels of n-6 PUFA before or during pregnancy may have detrimental effects on fetal development and may influence overall health of offspring in adulthood. This review discusses the role of n-6 PUFA in fetal programming, the importance of a balance between n-6 and n-3 PUFAs in the maternal diet, and the need of further animal models and human studies that critically evaluate both n-6 and n-3 PUFA contents in diets.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="38f480c7a889742cc9210b4ff53363cb" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91831209,"asset_id":87689869,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91831209/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689869"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689869"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689869; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689868"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87689868/Pregnancy_and_diet_related_changes_in_the_maternal_gut_microbiota_following_exposure_to_an_elevated_linoleic_acid_diet"><img alt="Research paper thumbnail of Pregnancy and diet-related changes in the maternal gut microbiota following exposure to an elevated linoleic acid diet" class="work-thumbnail" src="https://attachments.academia-assets.com/91831164/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87689868/Pregnancy_and_diet_related_changes_in_the_maternal_gut_microbiota_following_exposure_to_an_elevated_linoleic_acid_diet">Pregnancy and diet-related changes in the maternal gut microbiota following exposure to an elevated linoleic acid diet</a></div><div class="wp-workCard_item"><span>American Journal of Physiology-Endocrinology and Metabolism</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Dietary intakes of linoleic acid (LA) have increased, including in women of reproductive age. Cha...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Dietary intakes of linoleic acid (LA) have increased, including in women of reproductive age. Changes in maternal gut microbiome have been implicated in the metabolic adaptions that occur during pregnancy. We aimed to investigate whether consumption of a diet with elevated LA altered fecal microbiome diversity before and during pregnancy. Female Wistar-Kyoto rats consumed a high-LA diet (HLA: 6.21% of energy) or a low-LA diet (LLA: 1.44% of energy) for 10 wk before mating and during pregnancy. DNA was isolated from fecal samples before pregnancy [embryonic day 0 (E0)], or during pregnancy at E10 and E20. The microbiome composition was assessed with 16S rRNA sequencing. At E0, the beta-diversity of LLA and HLA groups differed with HLA rats having significantly lower abundance of the genera Akkermansia, Peptococcus, Sutterella, and Xo2d06 but higher abundance of Butyricimonas and Coprococcus. Over gestation, in LLA but not HLA rats, there was a reduction in alpha-diversity and an incr...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e867478c82ca4f33068414721be1eb0e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91831164,"asset_id":87689868,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91831164/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689868"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689868"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689868; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689867"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87689867/The_effect_of_high_maternal_linoleic_acid_on_endocannabinoid_signalling_in_rodent_hearts"><img alt="Research paper thumbnail of The effect of high maternal linoleic acid on endocannabinoid signalling in rodent hearts" class="work-thumbnail" src="https://attachments.academia-assets.com/91831207/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87689867/The_effect_of_high_maternal_linoleic_acid_on_endocannabinoid_signalling_in_rodent_hearts">The effect of high maternal linoleic acid on endocannabinoid signalling in rodent hearts</a></div><div class="wp-workCard_item"><span>Journal of Developmental Origins of Health and Disease</span><span>, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The endocannabinoid system (ECS), modulated by metabolites of linoleic acid (LA), is important in...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The endocannabinoid system (ECS), modulated by metabolites of linoleic acid (LA), is important in regulating cardiovascular function. In pregnancy, LA is vital for foetal development. We investigated the effects of elevated LA in H9c2 cardiomyoblasts in vitro and of a high linoleic acid (HLA, 6.21%) or low linoleic acid (LLA, 1.44%) diet during pregnancy in maternal and offspring hearts. H9c2 cell viability was reduced following LA exposure at concentrations between 300 and 1000 µM. HLA diet decreased cannabinoid receptor type 2 (CB2) mRNA expression in foetal hearts from both sexes. However, HLA diet increased CB2 expression in maternal hearts. The mRNA expression of fatty acid amide hydrolase (FAAH) in foetal hearts was higher in females than in males irrespective of diet and N-acyl phosphatidylethanolamine-specific phospholipase D (NAPE-PLD) mRNA expression showed an interaction between diet and sex. Data indicate that a high LA diet alters cell viability and CB2 expression, pote...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="cc3a3d3cc1b3d1b1fe77946152aaf587" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91831207,"asset_id":87689867,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91831207/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689867"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689867"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689867; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689866"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87689866/Peripheral_modulation_of_the_endocannabinoid_system_in_metabolic_disease"><img alt="Research paper thumbnail of Peripheral modulation of the endocannabinoid system in metabolic disease" class="work-thumbnail" src="https://attachments.academia-assets.com/91831199/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87689866/Peripheral_modulation_of_the_endocannabinoid_system_in_metabolic_disease">Peripheral modulation of the endocannabinoid system in metabolic disease</a></div><div class="wp-workCard_item"><span>Drug Discovery Today</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Highlights:  The endocannabinoid system (ECS) is dysregulated in obesity-associated diseases  C...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Highlights:  The endocannabinoid system (ECS) is dysregulated in obesity-associated diseases  CB1 antagonism is a potential therapeutic target for the treatment of obesity  CB1 antagonists have the potential for eliciting severe psychiatric side effects  Antagonists of CB1 that do not cross the blood-brain barrier are in development  Peripherally restricted CB1 antagonists are novel therapeutic targets for obesity Teaser: This Keynote review discusses the peripheral modulation of the ECS in liver, adipose tissue, heart, skeletal muscle, gastrointestinal tract, pancreas, kidney and the immunoinflammatory system. Dysfunction of the endocannabinoid system (ECS) has been identified in metabolic disease. Cannabinoid receptor 1 (CB1) is abundantly expressed in the brain but also expressed in the periphery. Cannabinoid receptor 2 (CB2) is more abundant in the periphery, including the immune cells. In obesity, global antagonism of overexpressed CB1 reduces bodyweight but leads to centrally mediated adverse psychological outcomes. Emerging research in isolated cultured cells or tissues has demonstrated that targeting the endocannabinoid system in the periphery alleviates the pathologies associated with metabolic disease. Further, peripheral specific cannabinoid ligands can reverse aspects of the metabolic phenotype. This Keynote review will focus on current research on the functionality of peripheral modulation of the ECS for the treatment of obesity.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1d03708af243e3fc5670e154b03c6bbe" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91831199,"asset_id":87689866,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91831199/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689866"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689866"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689866; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="87689865"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/87689865/The_fate_of_hepatocyte_cell_line_derived_from_a_liver_injury_model_with_long_term_in_vitro_passage"><img alt="Research paper thumbnail of The fate of hepatocyte cell line derived from a liver injury model with long-term in vitro passage" class="work-thumbnail" src="https://attachments.academia-assets.com/91831204/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/87689865/The_fate_of_hepatocyte_cell_line_derived_from_a_liver_injury_model_with_long_term_in_vitro_passage">The fate of hepatocyte cell line derived from a liver injury model with long-term in vitro passage</a></div><div class="wp-workCard_item"><span>Molecular & Cellular Toxicology</span><span>, 2018</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Backgrounds: orthotopic liver Transplantation (olT) is the therapy of choice for the treatment of...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Backgrounds: orthotopic liver Transplantation (olT) is the therapy of choice for the treatment of end-stage liver disease, but the severe shortage of organ donors, complex and expensive surgical procedure and increased mortality of prospective organ recipient limit the use of olT. To overcome this problem the technique of hepatocyte transplantation has been considered as an alternative to olT. Hepatocyte transplantation is less invasive, cost effective cryo-preservable and can be distributed from single donor to multiple recipients. in this study we have established and characterize the hepatocyte cell line possessing the morphological and functional characteristics of hepatocytes from chemically injured liver. Hence we hypothesized that the hepatocyte cell line derived from liver injury can be used for hepatocyte transplantation. Methods: To induce the priming of hepatocyte, mice were fed with 3,5-diethoxycarbonyl-1,4-dihydro-collidine (DDC) diet for 3 weeks and hepatocytes were obtained by two step collagenase perfusion method, hepatocytes hence obtained was expended by >300 passages and tested for various hepatocyte specific functions. Results: The cell line derived from liver injury model retains morphological and functional characteristics of hepatocytes in long-term in vitro culture. These cells transplanted to mice showed significant survival rate. Conclusion: The Hepatocyte cell line derived from liver injury model were used for hepatocyte transplantation and showed the significantly higher survival rate.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="36ea3b81118835ce7cb5061c16aa3e1a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":91831204,"asset_id":87689865,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/91831204/download_file?s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="87689865"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="87689865"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 87689865; 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