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<span>Function</span> </div> </a> <ul id="toc-Function-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Clinical_significance" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Clinical_significance"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Clinical significance</span> </div> </a> <button aria-controls="toc-Clinical_significance-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Clinical significance subsection</span> </button> <ul id="toc-Clinical_significance-sublist" class="vector-toc-list"> <li id="toc-Alzheimer's_disease" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Alzheimer's_disease"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.1</span> <span>Alzheimer's disease</span> </div> </a> <ul id="toc-Alzheimer's_disease-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Cardiovascular_disease" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Cardiovascular_disease"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.2</span> <span>Cardiovascular disease</span> </div> </a> <ul id="toc-Cardiovascular_disease-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Cancer" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Cancer"> <div class="vector-toc-text"> <span class="vector-toc-numb">3.3</span> <span>Cancer</span> </div> </a> <ul id="toc-Cancer-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Interactions" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Interactions"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Interactions</span> </div> </a> <button 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href="https://de.wikipedia.org/wiki/Low_Density_Lipoprotein_Receptor-related_Protein_1" title="Low Density Lipoprotein Receptor-related Protein 1 – German" lang="de" hreflang="de" data-title="Low Density Lipoprotein Receptor-related Protein 1" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/CD91" title="CD91 – Galician" lang="gl" hreflang="gl" data-title="CD91" data-language-autonym="Galego" data-language-local-name="Galician" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-hr mw-list-item"><a href="https://hr.wikipedia.org/wiki/LRP1" title="LRP1 – Croatian" lang="hr" hreflang="hr" data-title="LRP1" data-language-autonym="Hrvatski" data-language-local-name="Croatian" class="interlanguage-link-target"><span>Hrvatski</span></a></li><li class="interlanguage-link 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class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">hide</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Mammalian protein found in Homo sapiens</div> <p class="mw-empty-elt"> </p> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">LRP1</th></tr><tr><td colspan="4" style="text-align:center"><span typeof="mw:File"><a href="/wiki/File:Protein_LRP1_PDB_1cr8.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/b/bb/Protein_LRP1_PDB_1cr8.png/250px-Protein_LRP1_PDB_1cr8.png" decoding="async" width="250" height="205" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/b/bb/Protein_LRP1_PDB_1cr8.png 1.5x" data-file-width="362" data-file-height="297" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Available structures</th></tr><tr><th rowspan="2" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;width:43px"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit">Ortholog search: <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=Q91ZX7%20or%20Q07954%20or%20H0YJ88">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:Q91ZX7,Q07954,H0YJ88">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="text-align:center"><th colspan="2" style="background-color:light-dark(#ddd, #404244) !important;color:inherit">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1CR8">1CR8</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1D2L">1D2L</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1J8E">1J8E</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2FYJ">2FYJ</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2FYL">2FYL</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2KNX">2KNX</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2KNY">2KNY</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Identifiers</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/6692">LRP1</a></span>, A2MR, APOER, APR, CD91, IGFBP3R, LRP, LRP1A, TGFBR5, low density lipoprotein receptor-related protein 1, LDL receptor related protein 1, KPA, IGFBP3R1, IGFBP-3R</td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">External IDs</th><td colspan="3" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/107770">107770</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:96828">96828</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=1744">1744</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=LRP1">LRP1</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000123384">LRP1 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_12.svg" class="mw-file-description" title="Chromosome 12 (human)"><img alt="Chromosome 12 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e7/Ideogram_human_chromosome_12.svg/330px-Ideogram_human_chromosome_12.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e7/Ideogram_human_chromosome_12.svg/450px-Ideogram_human_chromosome_12.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e7/Ideogram_human_chromosome_12.svg/600px-Ideogram_human_chromosome_12.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Chromosome_12_(human)" class="mw-redirect" title="Chromosome 12 (human)">Chromosome 12 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_12_ideogram.svg" class="mw-file-description" title="Chromosome 12 (human)"><img alt="Chromosome 12 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/Human_chromosome_12_ideogram.svg/330px-Human_chromosome_12_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/38/Human_chromosome_12_ideogram.svg/500px-Human_chromosome_12_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/38/Human_chromosome_12_ideogram.svg/960px-Human_chromosome_12_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 120.77390543668px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for LRP1"><img alt="Genomic location for LRP1" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 126.8px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for LRP1"><img alt="Genomic location for LRP1" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">12q13.3</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">57,128,483 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">57,213,361 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_10.svg" class="mw-file-description" title="Chromosome 10 (mouse)"><img alt="Chromosome 10 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4e/Ideogram_house_mouse_chromosome_10.svg/330px-Ideogram_house_mouse_chromosome_10.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4e/Ideogram_house_mouse_chromosome_10.svg/390px-Ideogram_house_mouse_chromosome_10.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4e/Ideogram_house_mouse_chromosome_10.svg/520px-Ideogram_house_mouse_chromosome_10.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">Chromosome 10 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_10.svg" class="mw-file-description" title="Chromosome 10 (mouse)"><img alt="Chromosome 10 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/03/Ideogram_of_house_mouse_chromosome_10.svg/330px-Ideogram_of_house_mouse_chromosome_10.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/03/Ideogram_of_house_mouse_chromosome_10.svg/500px-Ideogram_of_house_mouse_chromosome_10.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/03/Ideogram_of_house_mouse_chromosome_10.svg/960px-Ideogram_of_house_mouse_chromosome_10.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 281.3526505528px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for LRP1"><img alt="Genomic location for LRP1" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 287.4px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for LRP1"><img alt="Genomic location for LRP1" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">10|10 D3</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">127,374,030 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">127,457,017 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000123384">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">stromal cell of endometrium</li><br /><li style="line-height: 137%;">Descending thoracic aorta</li><br /><li style="line-height: 137%;">ascending aorta</li><br /><li style="line-height: 137%;">right ovary</li><br /><li style="line-height: 137%;">left ovary</li><br /><li style="line-height: 137%;">right coronary artery</li><br /><li style="line-height: 137%;">tibial nerve</li><br /><li style="line-height: 137%;">canal of the cervix</li><br /><li style="line-height: 137%;">sural nerve</li><br /><li style="line-height: 137%;">left coronary artery</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000040249">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">stroma of bone marrow</li><br /><li style="line-height: 137%;">superior frontal gyrus</li><br /><li style="line-height: 137%;">internal carotid artery</li><br /><li style="line-height: 137%;">external carotid artery</li><br /><li style="line-height: 137%;">ankle</li><br /><li style="line-height: 137%;">primary visual cortex</li><br /><li style="line-height: 137%;">lip</li><br /><li style="line-height: 137%;">choroid plexus of fourth ventricle</li><br /><li style="line-height: 137%;">cerebellar cortex</li><br /><li style="line-height: 137%;">perirhinal cortex</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000123384">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_LRP1_200785_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/5/53/PBB_GE_LRP1_200785_s_at_fs.png/250px-PBB_GE_LRP1_200785_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/53/PBB_GE_LRP1_200785_s_at_fs.png/375px-PBB_GE_LRP1_200785_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/53/PBB_GE_LRP1_200785_s_at_fs.png/500px-PBB_GE_LRP1_200785_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/File:PBB_GE_LRP1_200784_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/2/26/PBB_GE_LRP1_200784_s_at_fs.png/250px-PBB_GE_LRP1_200784_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/26/PBB_GE_LRP1_200784_s_at_fs.png/500px-PBB_GE_LRP1_200784_s_at_fs.png 1.5x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/4035/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Molecular function</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005509">calcium ion binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0034185">apolipoprotein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070325">lipoprotein particle receptor binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0044877">protein-containing complex binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046872">metal ion binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0002020">protease binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005041">low-density lipoprotein particle receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003723">RNA binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001540">amyloid-beta binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005044">scavenger receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0015026">coreceptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016964">alpha-2 macroglobulin receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030226">apolipoprotein receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032050">clathrin heavy chain binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0038023">signaling receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0038024">cargo receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043395">heparan sulfate proteoglycan binding</a></li></ul> </div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Cellular component</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016021">integral component of membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030666">endocytic vesicle membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005768">endosome</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005925">focal adhesion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043235">receptor complex</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005886">plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005887">integral component of plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005765">lysosomal membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043025">soma</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030425">dendrite</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005730">nucleolus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005905">clathrin-coated pit</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030136">clathrin-coated vesicle</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005634">nucleus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005737">cytoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005829">cytosol</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005769">early endosome</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016323">basolateral plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032593">insulin-responsive compartment</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0044295">axonal growth cone</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045177">apical part of cell</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0098797">plasma membrane protein complex</a></li></ul> </div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Biological process</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042157">lipoprotein metabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043524">negative regulation of neuron apoptotic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:2000587">negative regulation of platelet-derived growth factor receptor-beta signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010977">negative regulation of neuron projection development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006897">endocytosis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032956">regulation of actin cytoskeleton organization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032429">regulation of phospholipase A2 activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0097242">amyloid-beta clearance</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030178">negative regulation of Wnt signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007568">ageing</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0014912">negative regulation of smooth muscle cell migration</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032370">positive regulation of lipid transport</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006898">receptor-mediated endocytosis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035909">aorta morphogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001523">retinoid metabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032374">regulation of cholesterol transport</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051222">positive regulation of protein transport</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043277">apoptotic cell clearance</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007275">multicellular organism development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007205">protein kinase C-activating G protein-coupled receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010875">positive regulation of cholesterol efflux</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0021987">cerebral cortex development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008283">cell population proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042953">lipoprotein transport</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010715">regulation of extracellular matrix disassembly</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0002265">astrocyte activation involved in immune response</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006629">lipid metabolism</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006909">phagocytosis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007204">positive regulation of cytosolic calcium ion concentration</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010812">negative regulation of cell-substrate adhesion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010942">positive regulation of cell death</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010976">positive regulation of neuron projection development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031623">receptor internalization</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032092">positive regulation of protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035774">positive regulation of insulin secretion involved in cellular response to glucose stimulus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043066">negative regulation of apoptotic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0044242">cellular lipid catabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045056">transcytosis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045773">positive regulation of axon extension</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045807">positive regulation of endocytosis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048691">positive regulation of axon extension involved in regeneration</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048694">positive regulation of collateral sprouting of injured axon</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050766">positive regulation of phagocytosis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051481">negative regulation of cytosolic calcium ion concentration</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051895">negative regulation of focal adhesion assembly</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060548">negative regulation of cell death</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0061642">chemoattraction of axon</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070374">positive regulation of ERK1 and ERK2 cascade</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0150093">amyloid-beta clearance by transcytosis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0150094">amyloid-beta clearance by cellular catabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1900149">positive regulation of Schwann cell migration</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1900223">positive regulation of amyloid-beta clearance</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1903078">positive regulation of protein localization to plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1904109">positive regulation of cholesterol import</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1904646">cellular response to amyloid-beta</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1904754">positive regulation of vascular associated smooth muscle cell migration</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1905167">positive regulation of lysosomal protein catabolic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007041">lysosomal transport</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=4035&rn=1">4035</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=16971&rn=1">16971</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000123384;db=core">ENSG00000123384</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000040249;db=core">ENSMUSG00000040249</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q07954">Q07954</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q91ZX7">Q91ZX7</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_002332">NM_002332</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_008512">NM_008512</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_002323">NP_002323</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_032538">NP_032538</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr12:57128483-57213361">Chr 12: 57.13 – 57.21 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr10:127374030-127457017">Chr 10: 127.37 – 127.46 Mb</a></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q535544" class="extiw" title="d:Q535544">View/Edit Human</a></td><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q18252092" class="extiw" title="d:Q18252092">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Low density lipoprotein receptor-related protein 1</b> (<b>LRP1</b>), also known as <b>alpha-2-macroglobulin receptor</b> (<b>A2MR</b>), <b>apolipoprotein E receptor</b> (<b>APOER</b>) or <b>cluster of differentiation 91</b> (<b>CD91</b>), is a <a href="/wiki/Protein" title="Protein">protein</a> forming a <a href="/wiki/Receptor_(biochemistry)" title="Receptor (biochemistry)">receptor</a> found in the <a href="/wiki/Plasma_membrane" class="mw-redirect" title="Plasma membrane">plasma membrane</a> of <a href="/wiki/Cell_biology" title="Cell biology">cells</a> involved in receptor-mediated <a href="/wiki/Endocytosis" title="Endocytosis">endocytosis</a>. In humans, the LRP1 protein is encoded by the <i>LRP1</i> <a href="/wiki/Gene" title="Gene">gene</a>.<sup id="cite_ref-pmid3266596_5-0" class="reference"><a href="#cite_note-pmid3266596-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid2548950_6-0" class="reference"><a href="#cite_note-pmid2548950-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-entrez_7-0" class="reference"><a href="#cite_note-entrez-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> LRP1 is also a key <a href="/wiki/Signal_transduction" title="Signal transduction">signalling</a> protein and, thus, involved in various biological processes, such as <a href="/wiki/Lipoprotein" title="Lipoprotein">lipoprotein</a> <a href="/wiki/Metabolism" title="Metabolism">metabolism</a> and <a href="/wiki/Cell_motility" class="mw-redirect" title="Cell motility">cell motility</a>, and <a href="/wiki/Disease" title="Disease">diseases</a>, such as <a href="/wiki/Neurodegenerative_disease" title="Neurodegenerative disease">neurodegenerative diseases</a>, <a href="/wiki/Atherosclerosis" title="Atherosclerosis">atherosclerosis</a>, and <a href="/wiki/Cancer" title="Cancer">cancer</a>.<sup id="cite_ref-pmid23936774_8-0" class="reference"><a href="#cite_note-pmid23936774-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid16102056_9-0" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Structure">Structure</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=LRP1&action=edit&section=1" title="Edit section: Structure"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The <i>LRP1</i> gene encodes a 600 kDa <a href="/wiki/Precursor_protein" class="mw-redirect" title="Precursor protein">precursor protein</a> that is processed by <a href="/wiki/Furin" title="Furin">furin</a> in the trans-<a href="/wiki/Golgi_complex" class="mw-redirect" title="Golgi complex">Golgi complex</a>, resulting in a 515 kDa alpha-chain and an 85 kDa beta-chain associated non<a href="/wiki/Covalent_bond" title="Covalent bond">covalently</a>.<sup id="cite_ref-pmid23936774_8-1" class="reference"><a href="#cite_note-pmid23936774-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid26164207_10-0" class="reference"><a href="#cite_note-pmid26164207-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid24796846_11-0" class="reference"><a href="#cite_note-pmid24796846-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> As a member of the <a href="/wiki/LDLR" class="mw-redirect" title="LDLR">LDLR</a> family, LRP1 contains cysteine-rich complement-type repeats, <a href="/wiki/EGF_(gene)" class="mw-redirect" title="EGF (gene)">EGF (gene)</a> repeats, β-propeller domains, a <a href="/wiki/Transmembrane" class="mw-redirect" title="Transmembrane">transmembrane</a> domain, and a <a href="/wiki/Cytoplasmic" class="mw-redirect" title="Cytoplasmic">cytoplasmic</a> domain.<sup id="cite_ref-pmid16102056_9-1" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> The extracellular domain of LRP1 is the alpha-chain, which comprises four <a href="/wiki/Ligand" title="Ligand">ligand</a>-binding domains (numbered I-IV) containing two, eight, ten, and eleven cysteine-rich complement-type repeats, respectively.<sup id="cite_ref-pmid23936774_8-2" class="reference"><a href="#cite_note-pmid23936774-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid16102056_9-2" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid26164207_10-1" class="reference"><a href="#cite_note-pmid26164207-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid24796846_11-1" class="reference"><a href="#cite_note-pmid24796846-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> These repeats bind <a href="/wiki/Extracellular_matrix" title="Extracellular matrix">extracellular matrix</a> proteins, <a href="/wiki/Growth_factor" title="Growth factor">growth factors</a>, <a href="/wiki/Protease" title="Protease">proteases</a>, <a href="/wiki/Protease_inhibitor_(biology)" title="Protease inhibitor (biology)">protease inhibitor</a> <a href="/wiki/Protein_complexes" class="mw-redirect" title="Protein complexes">complexes</a>, and other proteins involved in <a href="/wiki/Lipoprotein" title="Lipoprotein">lipoprotein</a> <a href="/wiki/Metabolism" title="Metabolism">metabolism</a>.<sup id="cite_ref-pmid23936774_8-3" class="reference"><a href="#cite_note-pmid23936774-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid16102056_9-3" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> Of the four domains, II and IV bind the majority of the protein's ligands.<sup id="cite_ref-pmid24796846_11-2" class="reference"><a href="#cite_note-pmid24796846-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> The EGF repeats and β-propeller domains serve to release <a href="/wiki/Ligand" title="Ligand">ligands</a> in low <a href="/wiki/PH" title="PH">pH</a> conditions, such as inside <a href="/wiki/Endosome" title="Endosome">endosomes</a>, with the β-propeller postulated to displace the ligand at the ligand binding repeats.<sup id="cite_ref-pmid16102056_9-4" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> The transmembrane domain is the β-chain, which contains a 100-<a href="/wiki/Residue_(chemistry)#biochemistry" title="Residue (chemistry)">residue</a> <a href="/wiki/Cytoplasm" title="Cytoplasm">cytoplasmic</a> tail. This tail contains two NPxY motifs that are responsible for the protein's function in <a href="/wiki/Endocytosis" title="Endocytosis">endocytosis</a> and <a href="/wiki/Signal_transduction" title="Signal transduction">signal transduction</a>.<sup id="cite_ref-pmid23936774_8-4" class="reference"><a href="#cite_note-pmid23936774-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=LRP1&action=edit&section=2" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>LRP1 is a member of the LDLR family and ubiquitously expressed in multiple <a href="/wiki/Tissue_(biology)" title="Tissue (biology)">tissues</a>, though it is most abundant in <a href="/wiki/Blood_vessel" title="Blood vessel">vascular</a> <a href="/wiki/Smooth_muscle_cell" class="mw-redirect" title="Smooth muscle cell">smooth muscle cells</a> (SMCs), <a href="/wiki/Hepatocyte" title="Hepatocyte">hepatocytes</a>, and <a href="/wiki/Neuron" title="Neuron">neurons</a>.<sup id="cite_ref-pmid23936774_8-5" class="reference"><a href="#cite_note-pmid23936774-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid16102056_9-5" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> LRP1 plays a key role in intracellular signaling and endocytosis, which implicates it in many cellular and biological processes, including <a href="/wiki/Lipid" title="Lipid">lipid</a> and <a href="/wiki/Lipoprotein" title="Lipoprotein">lipoprotein</a> <a href="/wiki/Metabolism" title="Metabolism">metabolism</a>, <a href="/wiki/Protease" title="Protease">protease</a> <a href="/wiki/Proteolysis" title="Proteolysis">degradation</a>, <a href="/wiki/Platelet_derived_growth_factor_receptor" class="mw-redirect" title="Platelet derived growth factor receptor">platelet derived growth factor receptor</a> regulation, <a href="/wiki/Integrin" title="Integrin">integrin</a> maturation and recycling, regulation of vascular tone, regulation of <a href="/wiki/Blood_brain_barrier" class="mw-redirect" title="Blood brain barrier">blood brain barrier</a> <a href="/wiki/Semipermeable_membrane" title="Semipermeable membrane">permeability</a>, <a href="/wiki/Cell_growth" title="Cell growth">cell growth</a>, <a href="/wiki/Cell_migration" title="Cell migration">cell migration</a>, <a href="/wiki/Inflammation" title="Inflammation">inflammation</a>, and <a href="/wiki/Apoptosis" title="Apoptosis">apoptosis</a>, as well as <a href="/wiki/Disease" title="Disease">diseases</a> such as neurodegenerative diseases, atherosclerosis, and cancer.<sup id="cite_ref-entrez_7-1" class="reference"><a href="#cite_note-entrez-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid23936774_8-6" class="reference"><a href="#cite_note-pmid23936774-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid16102056_9-6" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid26164207_10-2" class="reference"><a href="#cite_note-pmid26164207-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid24796846_11-3" class="reference"><a href="#cite_note-pmid24796846-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> To elaborate, LRP1 mainly contributes to regulate protein activity by binding target proteins as a <a href="/wiki/Co-receptor" title="Co-receptor">co-receptor</a>, in conjunction with <a href="/wiki/Integral_membrane_protein" title="Integral membrane protein">integral membrane proteins</a> or adaptor proteins like <a href="/wiki/Plasmin" title="Plasmin">uPA</a>, to the <a href="/wiki/Lysosome" title="Lysosome">lysosome</a> for degradation.<sup id="cite_ref-pmid16102056_9-7" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid26164207_10-3" class="reference"><a href="#cite_note-pmid26164207-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid24796846_11-4" class="reference"><a href="#cite_note-pmid24796846-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> In lipoprotein metabolism, the interaction between LRP1 and <a href="/wiki/Apolipoprotein_E" title="Apolipoprotein E">APOE</a> stimulates a signaling pathway that leads to elevated intracellular <a href="/wiki/Cyclic_adenosine_monophosphate" title="Cyclic adenosine monophosphate">cAMP</a> levels, increased <a href="/wiki/Protein_kinase_A" title="Protein kinase A">protein kinase A</a> activity, inhibited SMC migration, and ultimately, protection against <a href="/wiki/Vascular_disease" title="Vascular disease">vascular disease</a>.<sup id="cite_ref-pmid16102056_9-8" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> While <a href="/wiki/Membrane-bound" class="mw-redirect" title="Membrane-bound">membrane-bound</a> LRP1 performs endocytic clearance of proteases and inhibitors, <a href="/wiki/Proteolytic_cleavage" class="mw-redirect" title="Proteolytic cleavage">proteolytic cleavage</a> of its <a href="/wiki/Ectodomain" title="Ectodomain">ectodomain</a> allows the free LRP1 to compete with the membrane-bound form and prevent their clearance.<sup id="cite_ref-pmid23936774_8-7" class="reference"><a href="#cite_note-pmid23936774-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> Several sheddases have been implicated in the proteolytic cleavage of LRP1 such as ADAM10,<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> ADAM12,<sup id="cite_ref-:0_13-0" class="reference"><a href="#cite_note-:0-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> ADAM17<sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> and MT1-MMP.<sup id="cite_ref-:0_13-1" class="reference"><a href="#cite_note-:0-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> LRP1 is also continuously endocytosed from the membrane and recycled back to the cell surface.<sup id="cite_ref-pmid16102056_9-9" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> Though the role of LRP1 in apoptosis is unclear, it is required for tPA to bind LRP1 in order to trigger the ERK1/2 signal cascade and promote cell survival.<sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Clinical_significance">Clinical significance</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=LRP1&action=edit&section=3" title="Edit section: Clinical significance"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Alzheimer's_disease"><span id="Alzheimer.27s_disease"></span>Alzheimer's disease</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=LRP1&action=edit&section=4" title="Edit section: Alzheimer's disease"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/Neuron" title="Neuron">Neurons</a> require <a href="/wiki/Cholesterol" title="Cholesterol">cholesterol</a> to function. Cholesterol is imported into the neuron by apolipoprotein E (<a href="/wiki/ApoE" class="mw-redirect" title="ApoE">apoE</a>) via LRP1 receptors on the cell surface. It has been theorized that a causal factor in <a href="/wiki/Alzheimer%27s" class="mw-redirect" title="Alzheimer's">Alzheimer's</a> is the decrease of LRP1 mediated by the metabolism of the amyloid precursor protein, leading to decreased neuronal cholesterol and increased amyloid beta.<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> </p><p>LRP1 is also implicated in the effective clearance of Aβ from the brain to the periphery across the <a href="/wiki/Blood%E2%80%93brain_barrier" title="Blood–brain barrier">blood-brain barrier</a>.<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> LRP1 mediates pathways that interact with astrocytes and pericytes, which are associated with the blood-brain barrier. In support of this, LRP1 expression is reduced in endothelial cells as a result of normal aging and Alzheimer's disease in humans and animal models of the disease.<sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-20" class="reference"><a href="#cite_note-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> This clearance mechanism is modulated by the <a href="/wiki/Apolipoprotein_E" title="Apolipoprotein E">apoE</a> isoforms, with the presence of the apoE4 isoform resulting in reduced transcytosis of Aβ in in vitro models of the blood-brain barrier.<sup id="cite_ref-21" class="reference"><a href="#cite_note-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> The reduced clearance appears to be, at least in part, as a result of an increase in the ectodomain shedding of LRP1 by sheddases, resulting in the formation of soluble LRP1 which is no longer able to transcytose the Aβ peptides.<sup id="cite_ref-22" class="reference"><a href="#cite_note-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> </p><p>In addition, over-accumulation of <a href="/wiki/Copper" title="Copper">copper</a> in the brain is associated with reduced LRP1 mediated clearance of <a href="/wiki/Amyloid_beta" title="Amyloid beta">amyloid beta</a> across the <a href="/wiki/Blood_brain_barrier" class="mw-redirect" title="Blood brain barrier">blood brain barrier</a>. This defective clearance may contribute to the buildup of neurotoxic amyloid-beta that <a href="/wiki/Alzheimer%27s_disease#Causes" title="Alzheimer's disease">is thought to contribute</a> to Alzheimer's disease.<sup id="cite_ref-pmid23959870_23-0" class="reference"><a href="#cite_note-pmid23959870-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Cardiovascular_disease">Cardiovascular disease</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=LRP1&action=edit&section=5" title="Edit section: Cardiovascular disease"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Studies have elucidated different roles for LRP1 in cellular processes relevant for cardiovascular disease. <a href="/wiki/Atherosclerosis" title="Atherosclerosis">Atherosclerosis</a> is the primary cause of cardiovascular disease such as stroke and heart attacks. In the liver LRP1 is important for the removal of atherogenic <a href="/wiki/Lipoproteins" class="mw-redirect" title="Lipoproteins">lipoproteins</a> (Chylomicron remnants, VLDL) and other proatherogenic ligands from the circulation.<sup id="cite_ref-pmid19667105_24-0" class="reference"><a href="#cite_note-pmid19667105-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9449704_25-0" class="reference"><a href="#cite_note-pmid9449704-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup> LRP1 has a cholesterol-independent role in atherosclerosis by modulating the activity and cellular localization of the <a href="/wiki/PDGFRB" title="PDGFRB">PDGFR-β</a> in vascular <a href="/wiki/Smooth_muscle_cells" class="mw-redirect" title="Smooth muscle cells">smooth muscle cells</a>.<sup id="cite_ref-pmid12690199_26-0" class="reference"><a href="#cite_note-pmid12690199-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid17505534_27-0" class="reference"><a href="#cite_note-pmid17505534-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup> Finally, LRP1 in <a href="/wiki/Macrophages" class="mw-redirect" title="Macrophages">macrophages</a> has an effect on atherosclerosis through the modulation of the extracellular matrix and inflammatory responses.<sup id="cite_ref-pmid21730304_28-0" class="reference"><a href="#cite_note-pmid21730304-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid17303763_29-0" class="reference"><a href="#cite_note-pmid17303763-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Cancer">Cancer</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=LRP1&action=edit&section=6" title="Edit section: Cancer"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>LRP1 is involved in tumorigenesis, and is proposed to be a tumor suppressor. Notably, LRP1 functions in clearing proteases such as <a href="/wiki/Plasmin" title="Plasmin">plasmin</a>, <a href="/wiki/PLAU" class="mw-redirect" title="PLAU">urokinase-type plasminogen activator</a>, and <a href="/wiki/Metalloproteinase" title="Metalloproteinase">metalloproteinases</a>, which contributes to prevention of <a href="/wiki/Metastasis" title="Metastasis">cancer invasion</a>, while its absence is linked to increased cancer invasion. However, the exact mechanisms require further study, as other studies have shown that LRP1 may also promote cancer invasion. One possible mechanism for the inhibitory function of LRP1 in cancer involves the LRP1-dependent endocytosis of 2′-hydroxycinnamaldehyde (HCA), resulting in decreased <a href="/wiki/Pepsin" title="Pepsin">pepsin</a> levels and, consequently, tumor progression.<sup id="cite_ref-pmid16102056_9-10" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> Alternatively, LRP1 may regulate <a href="/wiki/Focal_adhesion" title="Focal adhesion">focal adhesion</a> disassembly of cancer cells through the <a href="/wiki/Extracellular_signal-regulated_kinases" title="Extracellular signal-regulated kinases">ERK</a> and <a href="/wiki/JNK" class="mw-redirect" title="JNK">JNK</a> pathways to aid invasion.<sup id="cite_ref-pmid23936774_8-8" class="reference"><a href="#cite_note-pmid23936774-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> Moreover, LRP1 interacts with <a href="/wiki/PAI-1" class="mw-redirect" title="PAI-1">PAI-1</a> to recruit <a href="/wiki/Mast_cell" title="Mast cell">mast cells</a> (MCs) and induce their <a href="/wiki/Degranulation" title="Degranulation">degranulation</a>, resulting in the release of MC mediators, activation of an inflammatory response, and development of <a href="/wiki/Glioma" title="Glioma">glioma</a>.<sup id="cite_ref-pmid26164207_10-4" class="reference"><a href="#cite_note-pmid26164207-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=LRP1&action=edit&section=7" title="Edit section: Interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>LRP1 has been shown to <a href="/wiki/Protein-protein_interaction" class="mw-redirect" title="Protein-protein interaction">interact</a> with: </p> <style data-mw-deduplicate="TemplateStyles:r1184024115">.mw-parser-output .div-col{margin-top:0.3em;column-width:30em}.mw-parser-output .div-col-small{font-size:90%}.mw-parser-output .div-col-rules{column-rule:1px solid #aaa}.mw-parser-output .div-col dl,.mw-parser-output .div-col ol,.mw-parser-output .div-col ul{margin-top:0}.mw-parser-output .div-col li,.mw-parser-output .div-col dd{page-break-inside:avoid;break-inside:avoid-column}</style><div class="div-col" style="column-width: 20em;"> <ul><li><a href="/wiki/A2-Macroglobulin" class="mw-redirect" title="A2-Macroglobulin">A2-Macroglobulin</a>,<sup id="cite_ref-pmid16102056_9-11" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Amyloid_beta" title="Amyloid beta">β</a>-<a href="/wiki/Amyloid_precursor_protein" class="mw-redirect" title="Amyloid precursor protein">amyloid precursor protein</a>,<sup id="cite_ref-pmid16102056_9-12" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/APBB1" title="APBB1">APBB1</a>,<sup id="cite_ref-pmid9837937_30-0" class="reference"><a href="#cite_note-pmid9837937-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Apolipoprotein_E" title="Apolipoprotein E">APOE</a>,<sup id="cite_ref-pmid16102056_9-13" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-31" class="reference"><a href="#cite_note-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-32" class="reference"><a href="#cite_note-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Aprotinin" title="Aprotinin">Aprotinin</a>,<sup id="cite_ref-pmid16102056_9-14" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/C1S" class="mw-redirect" title="C1S">C1S</a>/<a href="/wiki/Urticarial_vasculitis#C1q" title="Urticarial vasculitis">C1q</a> <a href="/wiki/Enzyme_inhibitor" title="Enzyme inhibitor">inhibitor</a>,<sup id="cite_ref-pmid16102056_9-15" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Calreticulin" title="Calreticulin">CALR</a>,<sup id="cite_ref-pmid16102056_9-16" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid12821648_33-0" class="reference"><a href="#cite_note-pmid12821648-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/CD44" title="CD44">CD44</a>,<sup id="cite_ref-pmid23936774_8-9" class="reference"><a href="#cite_note-pmid23936774-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Chylomicron" title="Chylomicron">Chylomicron</a>,<sup id="cite_ref-pmid16102056_9-17" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Circumsporozoite_protein" title="Circumsporozoite protein">Circumsporozoite protein</a>,<sup id="cite_ref-pmid16102056_9-18" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Collectin" title="Collectin">Collectin</a>,<sup id="cite_ref-pmid16102056_9-19" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Complement_C3" class="mw-redirect" title="Complement C3">Complement C3</a>,<sup id="cite_ref-pmid16102056_9-20" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/CTGF" title="CTGF">CTGF</a>,<sup id="cite_ref-pmid16102056_9-21" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/DLG4" title="DLG4">DLG4</a>,<sup id="cite_ref-pmid10827173_34-0" class="reference"><a href="#cite_note-pmid10827173-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Elastase" title="Elastase">Elastase</a>,<sup id="cite_ref-pmid16102056_9-22" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Factor_IX" title="Factor IX">Factor IXa</a>,<sup id="cite_ref-pmid16102056_9-23" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Factor_VIIa" class="mw-redirect" title="Factor VIIa">Factor VIIa</a>,<sup id="cite_ref-pmid16102056_9-24" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Fibronectin" title="Fibronectin">Fibronectin</a>,<sup id="cite_ref-pmid16102056_9-25" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Gentamicin" title="Gentamicin">Gentamicin</a>,<sup id="cite_ref-pmid16102056_9-26" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/GIPC1" title="GIPC1">GIPC1</a>,<sup id="cite_ref-pmid10827173_34-1" class="reference"><a href="#cite_note-pmid10827173-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Heat_shock_proteins" class="mw-redirect" title="Heat shock proteins">Heat shock proteins</a>: <a href="/wiki/Gp96" class="mw-redirect" title="Gp96">gp96</a>, <a href="/wiki/Hsp70" title="Hsp70">hsp70</a>, <a href="/wiki/Hsp90" title="Hsp90">hsp90</a>,<sup id="cite_ref-pmid11290339_35-0" class="reference"><a href="#cite_note-pmid11290339-35"><span class="cite-bracket">[</span>35<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Heparin_cofactor_II" title="Heparin cofactor II">heparin cofactor II</a>,<sup id="cite_ref-pmid16102056_9-27" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Hepatic_lipase" title="Hepatic lipase">Hepatic lipase</a>,<sup id="cite_ref-pmid16102056_9-28" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/ITGB1BP1" title="ITGB1BP1">ITGB1BP1</a>,<sup id="cite_ref-pmid10827173_34-2" class="reference"><a href="#cite_note-pmid10827173-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Lactoferrin" title="Lactoferrin">Lactoferrin</a>,<sup id="cite_ref-pmid16102056_9-29" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Lipoprotein_lipase" title="Lipoprotein lipase">Lipoprotein lipase</a>,<sup id="cite_ref-pmid16102056_9-30" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Lipoprotein_lipase" title="Lipoprotein lipase">LPL</a>,<sup id="cite_ref-pmid7510694_36-0" class="reference"><a href="#cite_note-pmid7510694-36"><span class="cite-bracket">[</span>36<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid7989348_37-0" class="reference"><a href="#cite_note-pmid7989348-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid1281473_38-0" class="reference"><a href="#cite_note-pmid1281473-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/MAPK8IP1" title="MAPK8IP1">MAPK8IP1</a>,<sup id="cite_ref-pmid10827173_34-3" class="reference"><a href="#cite_note-pmid10827173-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/MAPK8IP2" title="MAPK8IP2">MAPK8IP2</a>,<sup id="cite_ref-pmid10827173_34-4" class="reference"><a href="#cite_note-pmid10827173-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Midkine" title="Midkine">Midkine</a>,<sup id="cite_ref-pmid16102056_9-31" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/MMP13" class="mw-redirect" title="MMP13">MMP13</a>,<sup id="cite_ref-pmid23936774_8-10" class="reference"><a href="#cite_note-pmid23936774-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid16102056_9-32" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/MMP2" title="MMP2">MMP2</a>,<sup id="cite_ref-pmid23936774_8-11" class="reference"><a href="#cite_note-pmid23936774-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/MMP9" title="MMP9">MMP9</a>,<sup id="cite_ref-pmid23936774_8-12" class="reference"><a href="#cite_note-pmid23936774-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid16102056_9-33" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Neuroserpin" title="Neuroserpin">Neuroserpin</a>,<sup id="cite_ref-pmid16102056_9-34" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Nexin" title="Nexin">Nexin-1</a>,<sup id="cite_ref-pmid16102056_9-35" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/NOS1AP" title="NOS1AP">NOS1AP</a>,<sup id="cite_ref-pmid10827173_34-5" class="reference"><a href="#cite_note-pmid10827173-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/PAI_2" class="mw-redirect" title="PAI 2">PAI 2</a>,<sup id="cite_ref-pmid23936774_8-13" class="reference"><a href="#cite_note-pmid23936774-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/PAI-1" class="mw-redirect" title="PAI-1">PAI-1</a>,<sup id="cite_ref-pmid23936774_8-14" class="reference"><a href="#cite_note-pmid23936774-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid26164207_10-5" class="reference"><a href="#cite_note-pmid26164207-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/PDGF" class="mw-redirect" title="PDGF">PDGF</a>,<sup id="cite_ref-pmid16102056_9-36" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Plasmin" title="Plasmin">tPA</a>,<sup id="cite_ref-pmid23936774_8-15" class="reference"><a href="#cite_note-pmid23936774-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid16102056_9-37" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Plasmin" title="Plasmin">uPA</a>,<sup id="cite_ref-pmid23936774_8-16" class="reference"><a href="#cite_note-pmid23936774-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid16102056_9-38" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Polymyxin_B" title="Polymyxin B">Polymyxin B</a>,<sup id="cite_ref-pmid16102056_9-39" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Protein_C_inhibitor" title="Protein C inhibitor">Protein C inhibitor</a>,<sup id="cite_ref-pmid16102056_9-40" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Pseudomonas_exotoxin" title="Pseudomonas exotoxin">Pseudomonas exotoxin</a> A,<sup id="cite_ref-pmid16102056_9-41" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Rap_GTP-binding_protein" title="Rap GTP-binding protein">RAP</a>,<sup id="cite_ref-pmid16102056_9-42" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Ricin" title="Ricin">Ricin</a> A,<sup id="cite_ref-pmid16102056_9-43" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/SHC1" title="SHC1">SHC1</a>,<sup id="cite_ref-pmid12789267_39-0" class="reference"><a href="#cite_note-pmid12789267-39"><span class="cite-bracket">[</span>39<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11854294_40-0" class="reference"><a href="#cite_note-pmid11854294-40"><span class="cite-bracket">[</span>40<span class="cite-bracket">]</span></a></sup> and</li> <li><a href="/wiki/Sphingolipid_activator_protein" class="mw-redirect" title="Sphingolipid activator protein">Sphingolipid activator protein</a>,<sup id="cite_ref-pmid16102056_9-44" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/SYNJ2BP" title="SYNJ2BP">SYNJ2BP</a>.<sup id="cite_ref-pmid10827173_34-6" class="reference"><a href="#cite_note-pmid10827173-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Tat_(HIV)" title="Tat (HIV)">Tat</a>,<sup id="cite_ref-pmid16102056_9-45" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Thrombin" title="Thrombin">Thrombin</a>,<sup id="cite_ref-pmid16102056_9-46" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Thrombospondin_1" title="Thrombospondin 1">THBS1</a>,<sup id="cite_ref-pmid16102056_9-47" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid14991768_41-0" class="reference"><a href="#cite_note-pmid14991768-41"><span class="cite-bracket">[</span>41<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9045712_42-0" class="reference"><a href="#cite_note-pmid9045712-42"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid7775583_43-0" class="reference"><a href="#cite_note-pmid7775583-43"><span class="cite-bracket">[</span>43<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Thrombospondin_2" class="mw-redirect" title="Thrombospondin 2">Thrombospondin 2</a>,<sup id="cite_ref-pmid16102056_9-48" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/TIMP1" title="TIMP1">TIMP1</a>,<sup id="cite_ref-pmid23936774_8-17" class="reference"><a href="#cite_note-pmid23936774-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/TIMP2" title="TIMP2">TIMP2</a>,<sup id="cite_ref-pmid23936774_8-18" class="reference"><a href="#cite_note-pmid23936774-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/TIMP3" title="TIMP3">TIMP3</a>,<sup id="cite_ref-pmid23936774_8-19" class="reference"><a href="#cite_note-pmid23936774-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Tissue_factor_pathway_inhibitor" title="Tissue factor pathway inhibitor">Tissue factor pathway inhibitor</a>,<sup id="cite_ref-pmid16102056_9-49" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Tissue_plasminogen_activator" class="mw-redirect" title="Tissue plasminogen activator">PLAT</a>,<sup id="cite_ref-pmid10632583_44-0" class="reference"><a href="#cite_note-pmid10632583-44"><span class="cite-bracket">[</span>44<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid1502153_45-0" class="reference"><a href="#cite_note-pmid1502153-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Transforming_growth_factor-%CE%B2" class="mw-redirect" title="Transforming growth factor-β">Transforming growth factor-β</a>,<sup id="cite_ref-pmid16102056_9-50" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Urokinase_receptor" title="Urokinase receptor">PLAUR</a>,<sup id="cite_ref-pmid11359936_46-0" class="reference"><a href="#cite_note-pmid11359936-46"><span class="cite-bracket">[</span>46<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/VLDL" class="mw-redirect" title="VLDL">VLDL</a>,<sup id="cite_ref-pmid16102056_9-51" class="reference"><a href="#cite_note-pmid16102056-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li></ul> </div> <div class="mw-heading mw-heading3"><h3 id="Interactive_pathway_map">Interactive pathway map</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=LRP1&action=edit&section=8" title="Edit section: Interactive pathway map"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><i>Click on genes, proteins and metabolites below to link to respective articles.</i> <sup id="cite_ref-WikiPathways_47-0" class="reference"><a href="#cite_note-WikiPathways-47"><span class="cite-bracket">[</span>§ 1<span class="cite-bracket">]</span></a></sup> </p> <div style="overflow:auto;"> <div class="thumb tleft"> <div class="thumbinner" style="width: 377px;"> <div class="thumbimage" style="width: 375px; height: 350px; overflow: hidden;"> <div style="position: relative; top: -174.8px; left: -140.0px; width: px"><div class="noresize">[[File:<div class="noresize thumb tnone" style=";"> <div class="thumbinner" style="overflow:hidden;width:830px;"> <div 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href="/wiki/CYP7A1" shape="rect" coords="348,151,399,171" alt="go to article" title="go to article" /><area href="/wiki/SOAT1" shape="rect" coords="396,185,456,205" alt="go to article" title="go to article" /><area href="/wiki/Dgat1" shape="rect" coords="664,142,724,162" alt="go to article" title="go to article" /><area href="/wiki/LDL_receptor" shape="rect" coords="159,315,219,335" alt="go to article" title="go to article" /><area href="/wiki/SCARB1" shape="rect" coords="446,318,506,338" alt="go to article" title="go to article" /><area href="/wiki/LRP1" shape="rect" coords="288,315,348,335" alt="go to article" title="go to article" /><area href="/wiki/Lipoprotein_lipase" shape="rect" coords="359,344,419,364" alt="go to article" title="go to article" /><area href="/wiki/Hepatic_lipase" shape="rect" coords="207,398,267,418" alt="go to article" title="go to article" /><area href="/wiki/Cholesterylester_transfer_protein" shape="rect" coords="281,436,341,456" alt="go to article" title="go to article" /><area href="/wiki/Lecithin-cholesterol_acyltransferase" shape="rect" coords="303,494,363,514" alt="go to article" title="go to article" /><area href="/wiki/ABCA1" shape="rect" coords="304,606,364,626" alt="go to article" title="go to article" /><area href="/wiki/Apolipoprotein_A1" shape="rect" coords="522,451,582,471" alt="go to article" title="go to article" /><area href="/wiki/APOA4" shape="rect" coords="468,536,528,556" alt="go to article" title="go to article" /><area href="/wiki/APOC1" shape="rect" coords="609,420,669,440" alt="go to article" title="go to article" /><area href="/wiki/Apolipoprotein_E" shape="rect" coords="609,400,669,420" alt="go to article" title="go to article" /><area href="/wiki/APOC2" shape="rect" coords="669,400,729,420" alt="go to article" title="go to article" /><area href="/wiki/Apolipoprotein_C3" shape="rect" coords="669,420,729,440" alt="go to article" title="go to article" /><area href="/wiki/PLTP" shape="rect" coords="522,431,582,451" alt="go to article" title="go to article" /><area href="/wiki/Cholesterol" shape="rect" coords="268,219,362,238" alt="go to article" title="go to article" /><area href="/wiki/Cholic_acid" shape="rect" coords="281,104,350,123" alt="go to article" title="go to article" /><area href="/wiki/Cholesterol" shape="rect" coords="194,620,263,639" alt="go to article" title="go to article" /><area href="/wiki/Acetyl-coa" shape="rect" coords="50,71,115,91" alt="go to article" title="go to article" /><area href="/wiki/Cholesteryl_ester" shape="rect" coords="470,218,555,238" alt="go to article" title="go to article" /><area href="/wiki/Fatty_acid" shape="rect" coords="411,114,466,134" alt="go to article" title="go to article" /><area href="/wiki/Phospholipid" shape="rect" coords="559,194,634,214" alt="go to article" title="go to article" /><area href="/wiki/Triglyceride" shape="rect" coords="655,230,735,250" alt="go to article" title="go to article" /><area href="/wiki/LDL" shape="rect" coords="135,362,167,382" alt="go to article" title="go to article" /><area href="/wiki/Intermediate_density_lipoprotein" shape="rect" coords="299,362,331,382" alt="go to article" title="go to article" /><area href="/wiki/VLDL" shape="rect" coords="415,383,447,403" alt="go to article" title="go to article" /><area href="/wiki/High-density_lipoprotein" shape="rect" coords="386,447,418,467" alt="go to article" title="go to article" /><area href="/wiki/ABCG5" shape="rect" coords="125,555,185,575" alt="go to article" title="go to article" /><area href="/wiki/ABCG8" shape="rect" coords="125,575,185,595" alt="go to article" title="go to article" /><area href="/wiki/ABCA1" shape="rect" coords="413,605,473,625" alt="go to article" title="go to article" /><area href="/wiki/Cholesterol" shape="rect" coords="509,622,577,641" alt="go to article" title="go to article" /><area href="/wiki/Apolipoprotein_B" shape="rect" coords="609,440,669,460" alt="go to article" title="go to article" /><area href="/wiki/APOA5" shape="rect" coords="669,440,729,460" alt="go to article" title="go to article" /><area href="/wiki/Microsomal_triglyceride_transfer_protein" shape="rect" coords="572,314,621,334" alt="go to article" title="go to article" /><area href="/wiki/Diglyceride" shape="rect" coords="583,96,629,116" alt="go to article" title="go to article" /><area href="/wiki/Squalene" shape="rect" coords="127,218,194,238" alt="go to article" title="go to article" /><area href="/wiki/Farnesyl-diphosphate_farnesyltransferase" shape="rect" coords="40,245,91,265" alt="go to article" title="go to article" /><area href="/wiki/Squalene_monooxygenase" shape="rect" coords="202,181,245,201" alt="go to article" title="go to article" /><area href="/wiki/Acyl-CoA" shape="rect" coords="498,114,552,134" alt="go to article" title="go to article" /><area href="/wiki/Acyl-CoA_synthetase" shape="rect" coords="431,76,533,96" alt="go to article" title="go to article" /><area href="/wiki/Protein_disulfide-isomerase" shape="rect" coords="572,294,621,314" alt="go to article" title="go to article" /><area href="/wiki/Cholesterol" shape="rect" coords="359,541,428,560" alt="go to article" title="go to article" /><area href="/wiki/APOA2" shape="rect" coords="522,471,582,491" alt="go to article" title="go to article" /><area href="/wiki/MiR-33" shape="rect" coords="348,666,428,686" alt="go to article" title="go to article" /><area href="/wiki/MiR-33" shape="rect" coords="348,686,428,706" alt="go to article" title="go to article" /></map><figcaption></figcaption></figure></div> </div> <div class="thumbcaption"></div> </div></div>|alt=Statin pathway <a rel="nofollow" class="external text" href="http://www.wikipathways.org/index.php/Pathway:WP430">edit</a>]]</div></div> </div> <div class="thumbcaption"> <div class="magnify"><a href="/wiki/File:StatinPathway_WP430.png" title="File:StatinPathway WP430.png"> </a></div>Statin pathway <a rel="nofollow" class="external text" href="http://www.wikipathways.org/index.php/Pathway:WP430">edit</a> </div> </div> </div> <div style="clear:both;" class=""></div><style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-WikiPathways-47"><span class="mw-cite-backlink"><b><a href="#cite_ref-WikiPathways_47-0">^</a></b></span> <span class="reference-text">The interactive pathway map can be edited at WikiPathways: <style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.wikipathways.org/index.php/Pathway:WP430">"Statin_Pathway_WP430"</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Statin_Pathway_WP430&rft_id=http%3A%2F%2Fwww.wikipathways.org%2Findex.php%2FPathway%3AWP430&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALRP1" class="Z3988"></span></span> </li> </ol></div></div> </div> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=LRP1&action=edit&section=9" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/Cluster_of_differentiation" title="Cluster of differentiation">Cluster of differentiation</a></li> <li><a href="/wiki/Low_density_lipoprotein_receptor_gene_family" class="mw-redirect" title="Low density lipoprotein receptor gene family">Low density lipoprotein receptor gene family</a></li></ul> <div style="clear:both;" class=""></div> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=LRP1&action=edit&section=10" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239543626" /><div class="reflist reflist-columns references-column-width reflist-columns-2"> <ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000123384">GRCh38: Ensembl release 89: ENSG00000123384</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000040249">GRCm38: Ensembl release 89: ENSMUSG00000040249</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=4035">"Human PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Human+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D4035&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALRP1" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=16971">"Mouse PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Mouse+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D16971&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALRP1" class="Z3988"></span></span> </li> <li id="cite_note-pmid3266596-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid3266596_5-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFHerzHamannRogneMyklebost1988" class="citation journal cs1">Herz J, Hamann U, Rogne S, Myklebost O, Gausepohl H, Stanley KK (Dec 1988). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC455121">"Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor"</a>. <i>The EMBO Journal</i>. <b>7</b> (13): <span class="nowrap">4119–</span>27. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fj.1460-2075.1988.tb03306.x">10.1002/j.1460-2075.1988.tb03306.x</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC455121">455121</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/3266596">3266596</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+EMBO+Journal&rft.atitle=Surface+location+and+high+affinity+for+calcium+of+a+500-kd+liver+membrane+protein+closely+related+to+the+LDL-receptor+suggest+a+physiological+role+as+lipoprotein+receptor&rft.volume=7&rft.issue=13&rft.pages=%3Cspan+class%3D%22nowrap%22%3E4119-%3C%2Fspan%3E27&rft.date=1988-12&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC455121%23id-name%3DPMC&rft_id=info%3Apmid%2F3266596&rft_id=info%3Adoi%2F10.1002%2Fj.1460-2075.1988.tb03306.x&rft.aulast=Herz&rft.aufirst=J&rft.au=Hamann%2C+U&rft.au=Rogne%2C+S&rft.au=Myklebost%2C+O&rft.au=Gausepohl%2C+H&rft.au=Stanley%2C+KK&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC455121&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALRP1" class="Z3988"></span></span> </li> <li id="cite_note-pmid2548950-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid2548950_6-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFMyklebostArhedenRogneGeurts_van_Kessel1989" class="citation journal cs1">Myklebost O, Arheden K, Rogne S, Geurts van Kessel A, Mandahl N, Herz J, et al. (Jul 1989). "The gene for the human putative apoE receptor is on chromosome 12 in the segment q13-14". <i>Genomics</i>. <b>5</b> (1): <span class="nowrap">65–</span>9. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2F0888-7543%2889%2990087-6">10.1016/0888-7543(89)90087-6</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/2548950">2548950</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Genomics&rft.atitle=The+gene+for+the+human+putative+apoE+receptor+is+on+chromosome+12+in+the+segment+q13-14&rft.volume=5&rft.issue=1&rft.pages=%3Cspan+class%3D%22nowrap%22%3E65-%3C%2Fspan%3E9&rft.date=1989-07&rft_id=info%3Adoi%2F10.1016%2F0888-7543%2889%2990087-6&rft_id=info%3Apmid%2F2548950&rft.aulast=Myklebost&rft.aufirst=O&rft.au=Arheden%2C+K&rft.au=Rogne%2C+S&rft.au=Geurts+van+Kessel%2C+A&rft.au=Mandahl%2C+N&rft.au=Herz%2C+J&rft.au=Stanley%2C+K&rft.au=Heim%2C+S&rft.au=Mitelman%2C+F&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALRP1" class="Z3988"></span></span> </li> <li id="cite_note-entrez-7"><span class="mw-cite-backlink">^ <a href="#cite_ref-entrez_7-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-entrez_7-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/gene/4035">"Entrez Gene: LRP1 low density lipoprotein receptor-related protein 1"</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Entrez+Gene%3A+LRP1+low+density+lipoprotein+receptor-related+protein+1&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fgene%2F4035&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALRP1" class="Z3988"></span></span> </li> <li id="cite_note-pmid23936774-8"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid23936774_8-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid23936774_8-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-pmid23936774_8-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-pmid23936774_8-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-pmid23936774_8-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-pmid23936774_8-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-pmid23936774_8-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-pmid23936774_8-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-pmid23936774_8-8"><sup><i><b>i</b></i></sup></a> <a href="#cite_ref-pmid23936774_8-9"><sup><i><b>j</b></i></sup></a> <a href="#cite_ref-pmid23936774_8-10"><sup><i><b>k</b></i></sup></a> <a href="#cite_ref-pmid23936774_8-11"><sup><i><b>l</b></i></sup></a> <a href="#cite_ref-pmid23936774_8-12"><sup><i><b>m</b></i></sup></a> <a href="#cite_ref-pmid23936774_8-13"><sup><i><b>n</b></i></sup></a> <a href="#cite_ref-pmid23936774_8-14"><sup><i><b>o</b></i></sup></a> <a href="#cite_ref-pmid23936774_8-15"><sup><i><b>p</b></i></sup></a> <a href="#cite_ref-pmid23936774_8-16"><sup><i><b>q</b></i></sup></a> <a href="#cite_ref-pmid23936774_8-17"><sup><i><b>r</b></i></sup></a> <a href="#cite_ref-pmid23936774_8-18"><sup><i><b>s</b></i></sup></a> <a href="#cite_ref-pmid23936774_8-19"><sup><i><b>t</b></i></sup></a></span> <span class="reference-text"><link 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href="#cite_ref-pmid16102056_9-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-8"><sup><i><b>i</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-9"><sup><i><b>j</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-10"><sup><i><b>k</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-11"><sup><i><b>l</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-12"><sup><i><b>m</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-13"><sup><i><b>n</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-14"><sup><i><b>o</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-15"><sup><i><b>p</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-16"><sup><i><b>q</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-17"><sup><i><b>r</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-18"><sup><i><b>s</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-19"><sup><i><b>t</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-20"><sup><i><b>u</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-21"><sup><i><b>v</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-22"><sup><i><b>w</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-23"><sup><i><b>x</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-24"><sup><i><b>y</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-25"><sup><i><b>z</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-26"><sup><i><b>aa</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-27"><sup><i><b>ab</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-28"><sup><i><b>ac</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-29"><sup><i><b>ad</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-30"><sup><i><b>ae</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-31"><sup><i><b>af</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-32"><sup><i><b>ag</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-33"><sup><i><b>ah</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-34"><sup><i><b>ai</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-35"><sup><i><b>aj</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-36"><sup><i><b>ak</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-37"><sup><i><b>al</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-38"><sup><i><b>am</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-39"><sup><i><b>an</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-40"><sup><i><b>ao</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-41"><sup><i><b>ap</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-42"><sup><i><b>aq</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-43"><sup><i><b>ar</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-44"><sup><i><b>as</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-45"><sup><i><b>at</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-46"><sup><i><b>au</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-47"><sup><i><b>av</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-48"><sup><i><b>aw</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-49"><sup><i><b>ax</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-50"><sup><i><b>ay</b></i></sup></a> <a href="#cite_ref-pmid16102056_9-51"><sup><i><b>az</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFLillisMikhailenkoStrickland2005" class="citation journal cs1">Lillis AP, Mikhailenko I, Strickland DK (Aug 2005). <a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fj.1538-7836.2005.01371.x">"Beyond endocytosis: 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id="CITEREFLoukinovaRanganathanKuznetsovGorlatova2002" class="citation journal cs1">Loukinova E, Ranganathan S, Kuznetsov S, Gorlatova N, Migliorini MM, Loukinov D, et al. (May 2002). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M200427200">"Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function between LRP and the PDGF"</a>. <i>The Journal of Biological Chemistry</i>. <b>277</b> (18): <span class="nowrap">15499–</span>506. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M200427200">10.1074/jbc.M200427200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11854294">11854294</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Platelet-derived+growth+factor+%28PDGF%29-induced+tyrosine+phosphorylation+of+the+low+density+lipoprotein+receptor-related+protein+%28LRP%29.+Evidence+for+integrated+co-receptor+function+between+LRP+and+the+PDGF&rft.volume=277&rft.issue=18&rft.pages=%3Cspan+class%3D%22nowrap%22%3E15499-%3C%2Fspan%3E506&rft.date=2002-05&rft_id=info%3Adoi%2F10.1074%2Fjbc.M200427200&rft_id=info%3Apmid%2F11854294&rft.aulast=Loukinova&rft.aufirst=E&rft.au=Ranganathan%2C+S&rft.au=Kuznetsov%2C+S&rft.au=Gorlatova%2C+N&rft.au=Migliorini%2C+MM&rft.au=Loukinov%2C+D&rft.au=Ulery%2C+PG&rft.au=Mikhailenko%2C+I&rft.au=Lawrence%2C+DA&rft.au=Strickland%2C+DK&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.M200427200&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALRP1" class="Z3988"></span></span> </li> <li id="cite_note-pmid14991768-41"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid14991768_41-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFWangHerndonRanganathanGodyna2004" class="citation journal cs1">Wang S, Herndon ME, Ranganathan S, Godyna S, Lawler J, Argraves WS, et al. 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(Jan 2000). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772406">"Role of tissue plasminogen activator receptor LRP in hippocampal long-term potentiation"</a>. <i>The Journal of Neuroscience</i>. <b>20</b> (2): <span class="nowrap">542–</span>9. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1523%2FJNEUROSCI.20-02-00542.2000">10.1523/JNEUROSCI.20-02-00542.2000</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772406">6772406</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10632583">10632583</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Neuroscience&rft.atitle=Role+of+tissue+plasminogen+activator+receptor+LRP+in+hippocampal+long-term+potentiation&rft.volume=20&rft.issue=2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E542-%3C%2Fspan%3E9&rft.date=2000-01&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6772406%23id-name%3DPMC&rft_id=info%3Apmid%2F10632583&rft_id=info%3Adoi%2F10.1523%2FJNEUROSCI.20-02-00542.2000&rft.aulast=Zhuo&rft.aufirst=M&rft.au=Holtzman%2C+DM&rft.au=Li%2C+Y&rft.au=Osaka%2C+H&rft.au=DeMaro%2C+J&rft.au=Jacquin%2C+M&rft.au=Bu%2C+G&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6772406&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALRP1" class="Z3988"></span></span> </li> <li id="cite_note-pmid1502153-45"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid1502153_45-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFOrthMadisonGethingSambrook1992" class="citation journal cs1">Orth K, Madison EL, Gething MJ, Sambrook JF, Herz J (Aug 1992). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC49722">"Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. <b>89</b> (16): <span class="nowrap">7422–</span>6. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1992PNAS...89.7422O">1992PNAS...89.7422O</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.89.16.7422">10.1073/pnas.89.16.7422</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC49722">49722</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1502153">1502153</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Complexes+of+tissue-type+plasminogen+activator+and+its+serpin+inhibitor+plasminogen-activator+inhibitor+type+1+are+internalized+by+means+of+the+low+density+lipoprotein+receptor-related+protein%2Falpha+2-macroglobulin+receptor&rft.volume=89&rft.issue=16&rft.pages=%3Cspan+class%3D%22nowrap%22%3E7422-%3C%2Fspan%3E6&rft.date=1992-08&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC49722%23id-name%3DPMC&rft_id=info%3Apmid%2F1502153&rft_id=info%3Adoi%2F10.1073%2Fpnas.89.16.7422&rft_id=info%3Abibcode%2F1992PNAS...89.7422O&rft.aulast=Orth&rft.aufirst=K&rft.au=Madison%2C+EL&rft.au=Gething%2C+MJ&rft.au=Sambrook%2C+JF&rft.au=Herz%2C+J&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC49722&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALRP1" class="Z3988"></span></span> </li> <li id="cite_note-pmid11359936-46"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid11359936_46-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFCzekayKuemmelOrlandoFarquhar2001" class="citation journal cs1">Czekay RP, Kuemmel TA, Orlando RA, Farquhar MG (May 2001). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC34598">"Direct binding of occupied urokinase receptor (uPAR) to LDL receptor-related protein is required for endocytosis of uPAR and regulation of cell surface urokinase activity"</a>. <i>Molecular Biology of the Cell</i>. <b>12</b> (5): <span class="nowrap">1467–</span>79. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1091%2Fmbc.12.5.1467">10.1091/mbc.12.5.1467</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC34598">34598</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11359936">11359936</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+Biology+of+the+Cell&rft.atitle=Direct+binding+of+occupied+urokinase+receptor+%28uPAR%29+to+LDL+receptor-related+protein+is+required+for+endocytosis+of+uPAR+and+regulation+of+cell+surface+urokinase+activity&rft.volume=12&rft.issue=5&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1467-%3C%2Fspan%3E79&rft.date=2001-05&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC34598%23id-name%3DPMC&rft_id=info%3Apmid%2F11359936&rft_id=info%3Adoi%2F10.1091%2Fmbc.12.5.1467&rft.aulast=Czekay&rft.aufirst=RP&rft.au=Kuemmel%2C+TA&rft.au=Orlando%2C+RA&rft.au=Farquhar%2C+MG&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC34598&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALRP1" class="Z3988"></span></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=LRP1&action=edit&section=11" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 30em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFLiDaiZhengLiu2002" class="citation journal cs1">Li Z, Dai J, Zheng H, Liu B, Caudill M (Mar 2002). "An integrated view of the roles and mechanisms of heat shock protein gp96-peptide complex in eliciting immune response". <i>Frontiers in Bioscience</i>. <b>7</b> (4): d731–51. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.2741%2FA808">10.2741/A808</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11861214">11861214</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Frontiers+in+Bioscience&rft.atitle=An+integrated+view+of+the+roles+and+mechanisms+of+heat+shock+protein+gp96-peptide+complex+in+eliciting+immune+response&rft.volume=7&rft.issue=4&rft.pages=d731-51&rft.date=2002-03&rft_id=info%3Adoi%2F10.2741%2FA808&rft_id=info%3Apmid%2F11861214&rft.aulast=Li&rft.aufirst=Z&rft.au=Dai%2C+J&rft.au=Zheng%2C+H&rft.au=Liu%2C+B&rft.au=Caudill%2C+M&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALRP1" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFvan_der_Geer2002" class="citation journal cs1">van der Geer P (May 2002). "Phosphorylation of LRP1: regulation of transport and signal transduction". <i>Trends in Cardiovascular Medicine</i>. <b>12</b> (4): <span class="nowrap">160–</span>5. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS1050-1738%2802%2900154-8">10.1016/S1050-1738(02)00154-8</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12069755">12069755</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Trends+in+Cardiovascular+Medicine&rft.atitle=Phosphorylation+of+LRP1%3A+regulation+of+transport+and+signal+transduction&rft.volume=12&rft.issue=4&rft.pages=%3Cspan+class%3D%22nowrap%22%3E160-%3C%2Fspan%3E5&rft.date=2002-05&rft_id=info%3Adoi%2F10.1016%2FS1050-1738%2802%2900154-8&rft_id=info%3Apmid%2F12069755&rft.aulast=van+der+Geer&rft.aufirst=P&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALRP1" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFMayHerz2003" class="citation journal cs1">May P, Herz J (May 2003). <a rel="nofollow" class="external text" href="https://doi.org/10.1034%2Fj.1600-0854.2003.00086_4_5.x">"LDL receptor-related proteins in neurodevelopment"</a>. <i>Traffic</i>. <b>4</b> (5): <span class="nowrap">291–</span>301. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1034%2Fj.1600-0854.2003.00086_4_5.x">10.1034/j.1600-0854.2003.00086_4_5.x</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12713657">12713657</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:23565545">23565545</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Traffic&rft.atitle=LDL+receptor-related+proteins+in+neurodevelopment&rft.volume=4&rft.issue=5&rft.pages=%3Cspan+class%3D%22nowrap%22%3E291-%3C%2Fspan%3E301&rft.date=2003-05&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A23565545%23id-name%3DS2CID&rft_id=info%3Apmid%2F12713657&rft_id=info%3Adoi%2F10.1034%2Fj.1600-0854.2003.00086_4_5.x&rft.aulast=May&rft.aufirst=P&rft.au=Herz%2C+J&rft_id=https%3A%2F%2Fdoi.org%2F10.1034%252Fj.1600-0854.2003.00086_4_5.x&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALRP1" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFLlorente-CortésBadimon2005" class="citation journal cs1">Llorente-Cortés V, Badimon L (Mar 2005). <a rel="nofollow" class="external text" href="https://doi.org/10.1161%2F01.ATV.0000154280.62072.fd">"LDL receptor-related protein and the vascular wall: implications for atherothrombosis"</a>. <i>Arteriosclerosis, Thrombosis, and Vascular Biology</i>. <b>25</b> (3): <span class="nowrap">497–</span>504. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1161%2F01.ATV.0000154280.62072.fd">10.1161/01.ATV.0000154280.62072.fd</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15705932">15705932</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Arteriosclerosis%2C+Thrombosis%2C+and+Vascular+Biology&rft.atitle=LDL+receptor-related+protein+and+the+vascular+wall%3A+implications+for+atherothrombosis&rft.volume=25&rft.issue=3&rft.pages=%3Cspan+class%3D%22nowrap%22%3E497-%3C%2Fspan%3E504&rft.date=2005-03&rft_id=info%3Adoi%2F10.1161%2F01.ATV.0000154280.62072.fd&rft_id=info%3Apmid%2F15705932&rft.aulast=Llorente-Cort%C3%A9s&rft.aufirst=V&rft.au=Badimon%2C+L&rft_id=https%3A%2F%2Fdoi.org%2F10.1161%252F01.ATV.0000154280.62072.fd&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALRP1" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFHuangHuang2005" class="citation journal cs1">Huang SS, Huang JS (Oct 2005). <a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fjcb.20558">"TGF-beta control of cell proliferation"</a>. <i>Journal of Cellular Biochemistry</i>. <b>96</b> (3): <span class="nowrap">447–</span>62. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fjcb.20558">10.1002/jcb.20558</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16088940">16088940</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:83711249">83711249</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Cellular+Biochemistry&rft.atitle=TGF-beta+control+of+cell+proliferation&rft.volume=96&rft.issue=3&rft.pages=%3Cspan+class%3D%22nowrap%22%3E447-%3C%2Fspan%3E62&rft.date=2005-10&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A83711249%23id-name%3DS2CID&rft_id=info%3Apmid%2F16088940&rft_id=info%3Adoi%2F10.1002%2Fjcb.20558&rft.aulast=Huang&rft.aufirst=SS&rft.au=Huang%2C+JS&rft_id=https%3A%2F%2Fdoi.org%2F10.1002%252Fjcb.20558&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALRP1" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFLillisMikhailenkoStrickland2005" class="citation journal cs1">Lillis AP, Mikhailenko I, Strickland DK (Aug 2005). <a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fj.1538-7836.2005.01371.x">"Beyond endocytosis: LRP function in cell migration, proliferation and vascular permeability"</a>. <i>Journal of Thrombosis and Haemostasis</i>. <b>3</b> (8): <span class="nowrap">1884–</span>93. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fj.1538-7836.2005.01371.x">10.1111/j.1538-7836.2005.01371.x</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16102056">16102056</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:20991690">20991690</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Thrombosis+and+Haemostasis&rft.atitle=Beyond+endocytosis%3A+LRP+function+in+cell+migration%2C+proliferation+and+vascular+permeability&rft.volume=3&rft.issue=8&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1884-%3C%2Fspan%3E93&rft.date=2005-08&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A20991690%23id-name%3DS2CID&rft_id=info%3Apmid%2F16102056&rft_id=info%3Adoi%2F10.1111%2Fj.1538-7836.2005.01371.x&rft.aulast=Lillis&rft.aufirst=AP&rft.au=Mikhailenko%2C+I&rft.au=Strickland%2C+DK&rft_id=https%3A%2F%2Fdoi.org%2F10.1111%252Fj.1538-7836.2005.01371.x&rfr_id=info%3Asid%2Fen.wikipedia.org%3ALRP1" class="Z3988"></span></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=LRP1&action=edit&section=12" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?name=CD91+Antigen">CD91+Antigen</a> at the U.S. National Library of Medicine <a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">Medical Subject Headings</a> (MeSH)</li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol dl,.mw-parser-output .hlist ol ol,.mw-parser-output .hlist ol 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template" style="color:inherit">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:PDB_Gallery" title="Special:EditPage/Template:PDB Gallery"><abbr title="Edit this template" style="color:inherit">e</abbr></a></li></ul></div><div id="PDB_gallery11" style="font-size:114%;margin:0 4em">PDB gallery</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><ul class="gallery mw-gallery-traditional nochecker" style="line-height:130%"> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1cr8_EBI.jpg" class="mw-file-description" title="1cr8: LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN COMPLEMENT REPEAT 8"><img alt="1cr8: LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN COMPLEMENT REPEAT 8" src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e0/PDB_1cr8_EBI.jpg/250px-PDB_1cr8_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e0/PDB_1cr8_EBI.jpg/330px-PDB_1cr8_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e0/PDB_1cr8_EBI.jpg/500px-PDB_1cr8_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1cr8</b>: LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN COMPLEMENT REPEAT 8</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1d2l_EBI.jpg" class="mw-file-description" title="1d2l: NMR SOLUTION STRUCTURE OF COMPLEMENT-LIKE REPEAT CR3 FROM THE LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN (LRP). EVIDENCE FOR SPECIFIC BINDING TO THE RECEPTOR BINDING DOMAIN OF HUMAN ALPHA-2 MACROGLOBULIN"><img alt="1d2l: NMR SOLUTION STRUCTURE OF COMPLEMENT-LIKE REPEAT CR3 FROM THE LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN (LRP). EVIDENCE FOR SPECIFIC BINDING TO THE RECEPTOR BINDING DOMAIN OF HUMAN ALPHA-2 MACROGLOBULIN" src="//upload.wikimedia.org/wikipedia/commons/thumb/b/bb/PDB_1d2l_EBI.jpg/250px-PDB_1d2l_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/bb/PDB_1d2l_EBI.jpg/330px-PDB_1d2l_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/bb/PDB_1d2l_EBI.jpg/500px-PDB_1d2l_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1d2l</b>: NMR SOLUTION STRUCTURE OF COMPLEMENT-LIKE REPEAT CR3 FROM THE LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN (LRP). EVIDENCE FOR SPECIFIC BINDING TO THE RECEPTOR BINDING DOMAIN OF HUMAN ALPHA-2 MACROGLOBULIN</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1j8e_EBI.jpg" class="mw-file-description" title="1j8e: Crystal structure of ligand-binding repeat CR7 from LRP"><img alt="1j8e: Crystal structure of ligand-binding repeat CR7 from LRP" src="//upload.wikimedia.org/wikipedia/commons/thumb/9/97/PDB_1j8e_EBI.jpg/250px-PDB_1j8e_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/97/PDB_1j8e_EBI.jpg/330px-PDB_1j8e_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/97/PDB_1j8e_EBI.jpg/500px-PDB_1j8e_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1j8e</b>: Crystal structure of ligand-binding repeat CR7 from LRP</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_2fyj_EBI.png" class="mw-file-description" title="2fyj: NMR Solution structure of calcium-loaded LRP double module"><img alt="2fyj: NMR Solution structure of calcium-loaded LRP double module" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/19/PDB_2fyj_EBI.png/250px-PDB_2fyj_EBI.png" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/19/PDB_2fyj_EBI.png/330px-PDB_2fyj_EBI.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/19/PDB_2fyj_EBI.png/500px-PDB_2fyj_EBI.png 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>2fyj</b>: NMR Solution structure of calcium-loaded LRP double module</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_2fyl_EBI.jpg" class="mw-file-description" title="2fyl: Haddock model of the complex between double module of LRP, CR56, and first domain of receptor associated protein, RAP-d1."><img alt="2fyl: Haddock model of the complex between double module of LRP, CR56, and first domain of receptor associated protein, RAP-d1." src="//upload.wikimedia.org/wikipedia/commons/thumb/8/8e/PDB_2fyl_EBI.jpg/250px-PDB_2fyl_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/8e/PDB_2fyl_EBI.jpg/330px-PDB_2fyl_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/8e/PDB_2fyl_EBI.jpg/500px-PDB_2fyl_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>2fyl</b>: Haddock model of the complex between double module of LRP, CR56, and first domain of receptor associated protein, RAP-d1.</div> </li> </ul></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235" /></div><div role="navigation" class="navbox" aria-labelledby="Proteins:_clusters_of_differentiation_(see_also_list_of_human_clusters_of_differentiation)188" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#e7dcc3"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231" /><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Clusters_of_differentiation" title="Template:Clusters of differentiation"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Clusters_of_differentiation" title="Template talk:Clusters of differentiation"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Clusters_of_differentiation" title="Special:EditPage/Template:Clusters of differentiation"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Proteins:_clusters_of_differentiation_(see_also_list_of_human_clusters_of_differentiation)188" style="font-size:114%;margin:0 4em"><a href="/wiki/Protein" title="Protein">Proteins</a>: <a href="/wiki/Cluster_of_differentiation" title="Cluster of differentiation">clusters of differentiation</a> (see also <a href="/wiki/List_of_human_clusters_of_differentiation" title="List of human clusters of differentiation">list of human clusters of differentiation</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">1–50</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CD1" title="CD1">CD1</a> <ul><li><a href="/wiki/Group_1_CD1" class="mw-redirect" title="Group 1 CD1">a-c</a></li> <li><a href="/wiki/CD1A" title="CD1A">1A</a></li> <li><a href="/wiki/CD1b" title="CD1b">1B</a></li> <li><a href="/wiki/CD1D" title="CD1D">1D</a></li> <li><a href="/wiki/CD1E" title="CD1E">1E</a></li></ul></li> <li><a href="/wiki/CD2" title="CD2">CD2</a></li> <li><a href="/wiki/CD3_(immunology)" title="CD3 (immunology)">CD3</a> <ul><li><a href="/wiki/CD3G" title="CD3G">γ</a></li> <li><a href="/wiki/CD3D" title="CD3D">δ</a></li> <li><a href="/wiki/CD3E" class="mw-redirect" title="CD3E">ε</a></li></ul></li> <li><a href="/wiki/CD4" title="CD4">CD4</a></li> <li><a href="/wiki/CD5_(protein)" title="CD5 (protein)">CD5</a></li> <li><a href="/wiki/CD6" title="CD6">CD6</a></li> <li><a href="/wiki/CD7" title="CD7">CD7</a></li> <li><a href="/wiki/CD8" title="CD8">CD8</a> <ul><li><a href="/wiki/CD8A" title="CD8A">a</a></li></ul></li> <li><a href="/wiki/CD9" title="CD9">CD9</a></li> <li><a href="/wiki/Neprilysin" title="Neprilysin">CD10</a></li> <li><i>CD11</i> <ul><li><a href="/wiki/CD11a" class="mw-redirect" title="CD11a">a</a></li> <li><a href="/wiki/Integrin_alpha_M" title="Integrin alpha M">b</a></li> <li><a href="/wiki/CD11c" class="mw-redirect" title="CD11c">c</a></li> <li><a href="/wiki/ITGAD" class="mw-redirect" title="ITGAD">d</a></li></ul></li> <li><a href="/wiki/Alanine_aminopeptidase" title="Alanine aminopeptidase">CD13</a></li> <li><a href="/wiki/CD14" title="CD14">CD14</a></li> <li><a href="/wiki/CD15" class="mw-redirect" title="CD15">CD15</a></li> <li><a href="/wiki/CD16" title="CD16">CD16</a> <ul><li><a href="/wiki/FCGR3A" title="FCGR3A">A</a></li> <li><a href="/wiki/FCGR3B" title="FCGR3B">B</a></li></ul></li> <li><a href="/wiki/CD18" class="mw-redirect" title="CD18">CD18</a></li> <li><a href="/wiki/CD19" title="CD19">CD19</a></li> <li><a href="/wiki/CD20" title="CD20">CD20</a></li> <li><a href="/wiki/Complement_receptor_2" title="Complement receptor 2">CD21</a></li> <li><a href="/wiki/CD22" title="CD22">CD22</a></li> <li><a href="/wiki/CD23" title="CD23">CD23</a></li> <li><a href="/wiki/CD24" title="CD24">CD24</a></li> <li><a href="/wiki/IL2RA" title="IL2RA">CD25</a></li> <li><a href="/wiki/Dipeptidyl_peptidase-4" title="Dipeptidyl peptidase-4">CD26</a></li> <li><a href="/wiki/CD27" title="CD27">CD27</a></li> <li><a href="/wiki/CD28" title="CD28">CD28</a></li> <li><a href="/wiki/Integrin_beta_1" title="Integrin beta 1">CD29</a></li> <li><a href="/wiki/CD30" title="CD30">CD30</a></li> <li><a href="/wiki/CD31" title="CD31">CD31</a></li> <li><a href="/wiki/CD32" title="CD32">CD32</a> <ul><li><a href="/wiki/FCGR2A" title="FCGR2A">A</a></li> <li><a href="/wiki/FCGR2B" title="FCGR2B">B</a></li></ul></li> <li><a href="/wiki/CD33" title="CD33">CD33</a></li> <li><a href="/wiki/CD34" title="CD34">CD34</a></li> <li><a href="/wiki/Complement_receptor_1" title="Complement receptor 1">CD35</a></li> <li><a href="/wiki/CD36" title="CD36">CD36</a></li> <li><a href="/wiki/CD37" title="CD37">CD37</a></li> <li><a href="/wiki/CD38" title="CD38">CD38</a></li> <li><a href="/wiki/ENTPD1" title="ENTPD1">CD39</a></li> <li><a href="/wiki/CD40_(protein)" title="CD40 (protein)">CD40</a></li> <li><a href="/wiki/ITGA2B" class="mw-redirect" title="ITGA2B">CD41</a></li> <li><a href="/wiki/Glycoprotein_Ib" title="Glycoprotein Ib">CD42</a> <ul><li><a href="/wiki/Glycoprotein_IX" title="Glycoprotein IX">a</a></li> <li><a href="/wiki/GP1BA" title="GP1BA">b</a></li> <li><a href="/wiki/GP1BB" title="GP1BB">c</a></li> <li><a href="/wiki/GP5_(gene)" title="GP5 (gene)">d</a></li></ul></li> <li><a href="/wiki/CD43" title="CD43">CD43</a></li> <li><a href="/wiki/CD44" title="CD44">CD44</a></li> <li><a href="/wiki/PTPRC" title="PTPRC">CD45</a></li> <li><a href="/wiki/CD46" title="CD46">CD46</a></li> <li><a href="/wiki/CD47" title="CD47">CD47</a></li> <li><a href="/wiki/CD48" title="CD48">CD48</a></li> <li><i>CD49</i> <ul><li><a href="/wiki/CD49a" class="mw-redirect" title="CD49a">a</a></li> <li><a href="/wiki/CD49b" class="mw-redirect" title="CD49b">b</a></li> <li><a href="/wiki/CD49c" class="mw-redirect" title="CD49c">c</a></li> <li><a href="/wiki/CD49d" class="mw-redirect" title="CD49d">d</a></li> <li><a href="/wiki/ITGA5" class="mw-redirect" title="ITGA5">e</a></li> <li><a href="/wiki/ITGA6" class="mw-redirect" title="ITGA6">f</a></li></ul></li> <li><a href="/wiki/ICAM3" title="ICAM3">CD50</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">51–100</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ITGAV" class="mw-redirect" title="ITGAV">CD51</a></li> <li><a href="/wiki/CD52" title="CD52">CD52</a></li> <li><a href="/wiki/CD53" title="CD53">CD53</a></li> <li><a href="/wiki/ICAM-1" title="ICAM-1">CD54</a></li> <li><a href="/wiki/Decay-accelerating_factor" title="Decay-accelerating factor">CD55</a></li> <li><a href="/wiki/Neural_cell_adhesion_molecule" title="Neural cell adhesion molecule">CD56</a></li> <li><a href="/wiki/B3GAT1" title="B3GAT1">CD57</a></li> <li><a href="/wiki/CD58" title="CD58">CD58</a></li> <li><a href="/wiki/CD59" title="CD59">CD59</a></li> <li><a href="/wiki/CD61" class="mw-redirect" title="CD61">CD61</a></li> <li><a href="/wiki/Selectin" title="Selectin">CD62</a> <ul><li><a href="/wiki/E-selectin" title="E-selectin">E</a></li> <li><a href="/wiki/L-selectin" title="L-selectin">L</a></li> <li><a href="/wiki/P-selectin" title="P-selectin">P</a></li></ul></li> <li><a href="/wiki/CD63" title="CD63">CD63</a></li> <li><a href="/wiki/CD64_(biology)" title="CD64 (biology)">CD64</a> <ul><li><a href="/wiki/FCGR1A" title="FCGR1A">A</a></li> <li><a href="/wiki/FCGR1B" class="mw-redirect" title="FCGR1B">B</a></li> <li><a href="/wiki/FCGR1C" class="mw-redirect" title="FCGR1C">C</a></li></ul></li> <li><a href="/wiki/Carcinoembryonic_antigen" title="Carcinoembryonic antigen">CD66</a> <ul><li><a href="/wiki/CEACAM1" title="CEACAM1">a</a></li> <li><a href="/wiki/CEACAM8" title="CEACAM8">b</a></li> <li><a href="/wiki/CEACAM6" title="CEACAM6">c</a></li> <li><a href="/wiki/CEACAM3" title="CEACAM3">d</a></li> <li><a href="/wiki/CEACAM5" title="CEACAM5">e</a></li> <li><a href="/wiki/PSG1_(gene)" class="mw-redirect" title="PSG1 (gene)">f</a></li></ul></li> <li><a href="/wiki/CD68" title="CD68">CD68</a></li> <li><a href="/wiki/CD69" title="CD69">CD69</a></li> <li><a href="/wiki/CD70" title="CD70">CD70</a></li> <li><a href="/wiki/TFRC" class="mw-redirect" title="TFRC">CD71</a></li> <li><a href="/wiki/CD72" title="CD72">CD72</a></li> <li><a href="/wiki/NT5E" title="NT5E">CD73</a></li> <li><a href="/wiki/CD74" title="CD74">CD74</a></li> <li><a href="/wiki/CD78" title="CD78">CD78</a></li> <li><a href="/wiki/CD79" title="CD79">CD79</a> <ul><li><a href="/wiki/CD79A" title="CD79A">a</a></li> <li><a href="/wiki/CD79B" title="CD79B">b</a></li></ul></li> <li><a href="/wiki/CD80" title="CD80">CD80</a></li> <li><a href="/wiki/CD81" title="CD81">CD81</a></li> <li><a href="/wiki/CD82_(gene)" title="CD82 (gene)">CD82</a></li> <li><a href="/wiki/CD83" title="CD83">CD83</a></li> <li><a href="/wiki/CD84" title="CD84">CD84</a></li> <li><i>CD85</i> <ul><li><a href="/wiki/LILRB3" title="LILRB3">a</a></li> <li><a href="/wiki/LILRB2" title="LILRB2">d</a></li> <li><a href="/wiki/LILRA3" title="LILRA3">e</a></li> <li><a href="/wiki/LILRA2" title="LILRA2">h</a></li> <li><a href="/wiki/LILRB1" title="LILRB1">j</a></li> <li><a href="/wiki/LILRB4" title="LILRB4">k</a></li></ul></li> <li><a href="/wiki/CD86" title="CD86">CD86</a></li> <li><a href="/wiki/Urokinase_receptor" title="Urokinase receptor">CD87</a></li> <li><a href="/wiki/C5a_receptor" title="C5a receptor">CD88</a></li> <li><a href="/wiki/FCAR" title="FCAR">CD89</a></li> <li><a href="/wiki/CD90" title="CD90">CD90</a></li> <li><a class="mw-selflink selflink">CD91</a> - <a href="/wiki/SLC44A1" class="mw-redirect" title="SLC44A1">CD92</a></li> <li><a href="/wiki/CD93" title="CD93">CD93</a></li> <li><a href="/wiki/KLRD1" title="KLRD1">CD94</a></li> <li><a href="/wiki/Fas_receptor" title="Fas receptor">CD95</a></li> <li><a href="/wiki/CD96" title="CD96">CD96</a></li> <li><a href="/wiki/CD97" title="CD97">CD97</a></li> <li><a href="/wiki/CD98" title="CD98">CD98</a></li> <li><a href="/wiki/CD99" title="CD99">CD99</a></li> <li><a href="/wiki/SEMA4D" title="SEMA4D">CD100</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">101–150</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/IGSF2" title="IGSF2">CD101</a></li> <li><a href="/wiki/ICAM2" title="ICAM2">CD102</a></li> <li><a href="/wiki/ITGAE" title="ITGAE">CD103</a></li> <li><a href="/wiki/ITGB4" class="mw-redirect" title="ITGB4">CD104</a></li> <li><a href="/wiki/Endoglin" title="Endoglin">CD105</a></li> <li><a href="/wiki/VCAM-1" title="VCAM-1">CD106</a></li> <li><i>CD107</i> <ul><li><a href="/wiki/LAMP1" title="LAMP1">a</a></li> <li><a href="/wiki/LAMP2" title="LAMP2">b</a></li></ul></li> <li><a href="/wiki/SEMA7A" title="SEMA7A">CD108</a></li> <li><a href="/wiki/CD109" title="CD109">CD109</a></li> <li><a href="/wiki/Myeloproliferative_leukemia_virus_oncogene" class="mw-redirect" title="Myeloproliferative leukemia virus oncogene">CD110</a></li> <li><a href="/wiki/PVRL1" class="mw-redirect" title="PVRL1">CD111</a></li> <li><a href="/wiki/PVRL2" class="mw-redirect" title="PVRL2">CD112</a></li> <li><a href="/wiki/PVRL3" class="mw-redirect" title="PVRL3">CD113</a></li> <li><a href="/wiki/Granulocyte_colony-stimulating_factor_receptor" title="Granulocyte colony-stimulating factor receptor">CD114</a></li> <li><a href="/wiki/Colony_stimulating_factor_1_receptor" title="Colony stimulating factor 1 receptor">CD115</a></li> <li><a href="/wiki/Granulocyte_macrophage_colony-stimulating_factor_receptor" class="mw-redirect" title="Granulocyte macrophage colony-stimulating factor receptor">CD116</a></li> <li><a href="/wiki/KIT_(gene)" title="KIT (gene)">CD117</a></li> <li><a href="/wiki/Leukemia_inhibitory_factor_receptor" title="Leukemia inhibitory factor receptor">CD118</a></li> <li><a href="/wiki/Interferon_gamma_receptor_1" title="Interferon gamma receptor 1">CD119</a></li> <li><a href="/wiki/CD120" title="CD120">CD120</a> <ul><li><a href="/wiki/TNFRSF1A" class="mw-redirect" title="TNFRSF1A">a</a></li> <li><a href="/wiki/TNFRSF1B" class="mw-redirect" title="TNFRSF1B">b</a></li></ul></li> <li><i>CD121</i> <ul><li><a href="/wiki/Interleukin_1_receptor,_type_I" title="Interleukin 1 receptor, type I">a</a></li> <li><a href="/wiki/Interleukin_1_receptor,_type_II" title="Interleukin 1 receptor, type II">b</a></li></ul></li> <li><a href="/wiki/IL2RB" title="IL2RB">CD122</a></li> <li><a href="/wiki/IL3RA" title="IL3RA">CD123</a></li> <li><a href="/wiki/Interleukin-4_receptor" title="Interleukin-4 receptor">CD124</a></li> <li><a href="/wiki/Interleukin_5_receptor_alpha_subunit" title="Interleukin 5 receptor alpha subunit">CD125</a></li> <li><a href="/wiki/Interleukin-6_receptor" title="Interleukin-6 receptor">CD126</a></li> <li><a href="/wiki/Interleukin-7_receptor" title="Interleukin-7 receptor">CD127</a></li> <li><a href="/wiki/Interleukin-9_receptor" title="Interleukin-9 receptor">CD129</a></li> <li><a href="/wiki/Glycoprotein_130" title="Glycoprotein 130">CD130</a></li> <li><a href="/wiki/CSF2RB" title="CSF2RB">CD131</a></li> <li><a href="/wiki/Common_gamma_chain" title="Common gamma chain">CD132</a></li> <li><a href="/wiki/CD133" title="CD133">CD133</a></li> <li><a href="/wiki/CD134" title="CD134">CD134</a></li> <li><a href="/wiki/CD135" title="CD135">CD135</a></li> <li><a href="/wiki/MST1R" title="MST1R">CD136</a></li> <li><a href="/wiki/CD137" title="CD137">CD137</a></li> <li><a href="/wiki/Syndecan_1" title="Syndecan 1">CD138</a></li> <li><a href="/wiki/PDGFRB" title="PDGFRB">CD140b</a></li> <li><a href="/wiki/Thrombomodulin" title="Thrombomodulin">CD141</a></li> <li><a href="/wiki/Tissue_factor" title="Tissue factor">CD142</a></li> <li><a href="/wiki/Angiotensin-converting_enzyme" title="Angiotensin-converting enzyme">CD143</a></li> <li><a href="/wiki/VE-cadherin" title="VE-cadherin">CD144</a></li> <li><a href="/wiki/CD146" title="CD146">CD146</a></li> <li><a href="/wiki/Basigin" title="Basigin">CD147</a></li> <li><a href="/wiki/PTPRJ" title="PTPRJ">CD148</a></li> <li><a href="/wiki/SLAMF1" title="SLAMF1">CD150</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">151–200</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CD151" title="CD151">CD151</a></li> <li><a href="/wiki/CTLA-4" class="mw-redirect" title="CTLA-4">CD152</a></li> <li><a href="/wiki/CD153" title="CD153">CD153</a></li> <li><a href="/wiki/CD154" title="CD154">CD154</a></li> <li><a href="/wiki/CD155" title="CD155">CD155</a></li> <li><i>CD156</i> <ul><li><a href="/wiki/ADAM8" title="ADAM8">a</a></li> <li><a href="/wiki/ADAM17" title="ADAM17">b</a></li> <li><a href="/wiki/ADAM10" title="ADAM10">c</a></li></ul></li> <li><a href="/wiki/BST1" title="BST1">CD157</a></li> <li><i>CD158</i> (<a href="/wiki/KIR2DL1" title="KIR2DL1">a</a></li> <li><a href="/wiki/KIR2DL4" title="KIR2DL4">d</a></li> <li><a href="/wiki/KIR3DL1" title="KIR3DL1">e</a></li> <li><a href="/wiki/KIR2DS4" title="KIR2DS4">i</a></li> <li><a href="/wiki/KIR3DL2" title="KIR3DL2">k</a>)</li> <li><i>CD159</i> <ul><li><a href="/wiki/NKG2" title="NKG2">a</a></li> <li><a href="/wiki/KLRC2" title="KLRC2">c</a></li></ul></li> <li><a href="/wiki/CD160" title="CD160">CD160</a></li> <li><a href="/wiki/KLRB1" title="KLRB1">CD161</a></li> <li><a href="/wiki/P-selectin_glycoprotein_ligand-1" title="P-selectin glycoprotein ligand-1">CD162</a></li> <li><a href="/wiki/CD163" title="CD163">CD163</a></li> <li><a href="/wiki/CD164" title="CD164">CD164</a></li> <li><a href="/wiki/ALCAM" title="ALCAM">CD166</a></li> <li><i>CD167</i> <ul><li><a href="/wiki/DDR1" title="DDR1">a</a></li> <li><a href="/wiki/Discoidin_domain-containing_receptor_2" title="Discoidin domain-containing receptor 2">b</a></li></ul></li> <li><a href="/wiki/Hyaluronan-mediated_motility_receptor" title="Hyaluronan-mediated motility receptor">CD168</a></li> <li><a href="/wiki/Sialoadhesin" title="Sialoadhesin">CD169</a></li> <li><a href="/wiki/SIGLEC5" title="SIGLEC5">CD170</a></li> <li><a href="/wiki/L1_(protein)" title="L1 (protein)">CD171</a></li> <li><i>CD172</i> <ul><li><a href="/wiki/Signal-regulatory_protein_alpha" title="Signal-regulatory protein alpha">a</a></li> <li><a href="/wiki/SIRPB1" title="SIRPB1">b</a></li> <li><a href="/wiki/SIRPG" title="SIRPG">g</a></li></ul></li> <li><a href="/wiki/Fucosyltransferase_3" title="Fucosyltransferase 3">CD174</a></li> <li><a href="/wiki/CD177" title="CD177">CD177</a></li> <li><a href="/wiki/Fas_ligand" title="Fas ligand">CD178</a></li> <li><i>CD179</i> <ul><li><a href="/wiki/VPREB1" title="VPREB1">a</a></li> <li><a href="/wiki/IGLL1" title="IGLL1">b</a></li></ul></li> <li><a href="/wiki/CD180" title="CD180">CD180</a></li> <li><a href="/wiki/Interleukin_8_receptor,_alpha" title="Interleukin 8 receptor, alpha">CD181</a></li> <li><a href="/wiki/Interleukin_8_receptor,_beta" title="Interleukin 8 receptor, beta">CD182</a></li> <li><a href="/wiki/CXCR3" title="CXCR3">CD183</a></li> <li><a href="/wiki/CXCR4" title="CXCR4">CD184</a></li> <li><a href="/wiki/CXCR5" title="CXCR5">CD185</a></li> <li><a href="/wiki/CXCR6" title="CXCR6">CD186</a></li> <li><a href="/wiki/CCR1" title="CCR1">CD191</a></li> <li><a href="/wiki/CCR2" title="CCR2">CD192</a></li> <li><a href="/wiki/CCR3_(gene)" title="CCR3 (gene)">CD193</a></li> <li><a href="/wiki/CCR4" title="CCR4">CD194</a></li> <li><a href="/wiki/CCR5" title="CCR5">CD195</a></li> <li><a href="/wiki/C-C_chemokine_receptor_type_6" title="C-C chemokine receptor type 6">CD196</a></li> <li><a href="/wiki/C-C_chemokine_receptor_type_7" title="C-C chemokine receptor type 7">CD197</a></li> <li><a href="/wiki/CCR8_(gene)" title="CCR8 (gene)">CDw198</a></li> <li><a href="/wiki/CCR9" title="CCR9">CDw199</a></li> <li><a href="/wiki/CD200" title="CD200">CD200</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">201–250</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Endothelial_protein_C_receptor" title="Endothelial protein C receptor">CD201</a></li> <li><a href="/wiki/TEK_tyrosine_kinase" title="TEK tyrosine kinase">CD202b</a></li> <li><a href="/wiki/MSR1" title="MSR1">CD204</a></li> <li><a href="/wiki/LY75" class="mw-redirect" title="LY75">CD205</a></li> <li><a href="/wiki/Mannose_receptor" title="Mannose receptor">CD206</a></li> <li><a href="/wiki/CD207" class="mw-redirect" title="CD207">CD207</a></li> <li><a href="/wiki/LAMP3" title="LAMP3">CD208</a></li> <li><a href="/wiki/DC-SIGN" title="DC-SIGN">CD209</a></li> <li><i>CDw210</i> <ul><li><a href="/wiki/Interleukin_10_receptor,_alpha_subunit" title="Interleukin 10 receptor, alpha subunit">a</a></li> <li><a href="/wiki/Interleukin_10_receptor,_beta_subunit" title="Interleukin 10 receptor, beta subunit">b</a></li></ul></li> <li><a href="/wiki/Interleukin_12_receptor,_beta_1_subunit" title="Interleukin 12 receptor, beta 1 subunit">CD212</a></li> <li><i>CD213a</i> <ul><li><a href="/wiki/IL13RA1" class="mw-redirect" title="IL13RA1">1</a></li> <li><a href="/wiki/IL13RA2" title="IL13RA2">2</a></li></ul></li> <li><a href="/wiki/IL17RA" title="IL17RA">CD217</a></li> <li><i>CD218</i> (<a href="/wiki/IL18R1" title="IL18R1">a</a></li> <li><a href="/wiki/IL18RAP" title="IL18RAP">b</a>)</li> <li><a href="/wiki/Insulin_receptor" title="Insulin receptor">CD220</a></li> <li><a href="/wiki/Insulin-like_growth_factor_1_receptor" title="Insulin-like growth factor 1 receptor">CD221</a></li> <li><a href="/wiki/Insulin-like_growth_factor_2_receptor" title="Insulin-like growth factor 2 receptor">CD222</a></li> <li><a href="/wiki/LAG3" class="mw-redirect" title="LAG3">CD223</a></li> <li><a href="/wiki/GGT1" class="mw-redirect" title="GGT1">CD224</a></li> <li><a href="/wiki/IFITM1" title="IFITM1">CD225</a></li> <li><a href="/wiki/CD226" title="CD226">CD226</a></li> <li><a href="/wiki/MUC1" class="mw-redirect" title="MUC1">CD227</a></li> <li><a href="/wiki/MFI2" class="mw-redirect" title="MFI2">CD228</a></li> <li><a href="/wiki/LY9" title="LY9">CD229</a></li> <li><a href="/wiki/PRNP" class="mw-redirect" title="PRNP">CD230</a></li> <li><a href="/wiki/Band_3" class="mw-redirect" title="Band 3">CD233</a></li> <li><a href="/wiki/Duffy_antigen_system" title="Duffy antigen system">CD234</a></li> <li><i>CD235</i> <ul><li><a href="/wiki/GYPA" class="mw-redirect" title="GYPA">a</a></li> <li><a href="/wiki/GYPB" title="GYPB">b</a></li></ul></li> <li><a href="/wiki/Glycophorin_C" title="Glycophorin C">CD236</a></li> <li><a href="/wiki/Kell_antigen_system" title="Kell antigen system">CD238</a></li> <li><a href="/wiki/Basal_cell_adhesion_molecule" title="Basal cell adhesion molecule">CD239</a></li> <li><a href="/wiki/RHCE_(gene)" title="RHCE (gene)">CD240CE</a></li> <li><a href="/wiki/RHD_(gene)" title="RHD (gene)">CD240D</a></li> <li><a href="/wiki/RHAG" title="RHAG">CD241</a></li> <li><a href="/wiki/P-glycoprotein" title="P-glycoprotein">CD243</a></li> <li><a href="/wiki/CD244" title="CD244">CD244</a></li> <li><a href="/wiki/Anaplastic_lymphoma_kinase" title="Anaplastic lymphoma kinase">CD246</a></li> <li><a href="/wiki/CD247" class="mw-redirect" title="CD247">CD247</a> - <a href="/wiki/CD248" title="CD248">CD248</a></li> <li><a href="/wiki/Glutamyl_aminopeptidase" title="Glutamyl aminopeptidase">CD249</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">251–300</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/OX40L" class="mw-redirect" title="OX40L"> CD252</a></li> <li><a href="/wiki/TRAIL" title="TRAIL">CD253</a></li> <li><a href="/wiki/RANKL" title="RANKL">CD254</a></li> <li><a href="/wiki/TNFSF13" class="mw-redirect" title="TNFSF13">CD256</a></li> <li><a href="/wiki/B-cell_activating_factor" title="B-cell activating factor">CD257</a></li> <li><a href="/wiki/TNFSF14" class="mw-redirect" title="TNFSF14">CD258</a></li> <li><a href="/wiki/TNFRSF10A" class="mw-redirect" title="TNFRSF10A">CD261</a></li> <li><a href="/wiki/TNFRSF10B" class="mw-redirect" title="TNFRSF10B">CD262</a></li> <li><a href="/wiki/TNFRSF10C" class="mw-redirect" title="TNFRSF10C">CD263</a></li> <li><a href="/wiki/TNFRSF10D" class="mw-redirect" title="TNFRSF10D">CD264</a></li> <li><a href="/wiki/RANK" title="RANK">CD265</a></li> <li><a href="/wiki/TNFRSF12A" title="TNFRSF12A">CD266</a></li> <li><a href="/wiki/TNFRSF13B" class="mw-redirect" title="TNFRSF13B">CD267</a></li> <li><a href="/wiki/TNFRSF13C" class="mw-redirect" title="TNFRSF13C">CD268</a></li> <li><a href="/wiki/TNFRSF17" class="mw-redirect" title="TNFRSF17">CD269</a></li> <li><a href="/wiki/Low-affinity_nerve_growth_factor_receptor" title="Low-affinity nerve growth factor receptor">CD271</a></li> <li><a href="/wiki/BTLA" title="BTLA">CD272</a></li> <li><a href="/wiki/PDCD1LG2" title="PDCD1LG2">CD273</a></li> <li><a href="/wiki/CD274" class="mw-redirect" title="CD274">CD274</a></li> <li><a href="/wiki/ICOSLG" title="ICOSLG">CD275</a></li> <li><a href="/wiki/CD276" title="CD276">CD276</a></li> <li><a href="/wiki/CD278" title="CD278">CD278</a></li> <li><a href="/wiki/Programmed_cell_death_protein_1" title="Programmed cell death protein 1">CD279</a></li> <li><a href="/wiki/Mannose_receptor" title="Mannose receptor">CD280</a></li> <li><a href="/wiki/TLR_1" class="mw-redirect" title="TLR 1">CD281</a></li> <li><a href="/wiki/TLR2" class="mw-redirect" title="TLR2">CD282</a></li> <li><a href="/wiki/TLR3" class="mw-redirect" title="TLR3">CD283</a></li> <li><a href="/wiki/TLR4" class="mw-redirect" title="TLR4">CD284</a></li> <li><a href="/wiki/TLR6" class="mw-redirect" title="TLR6">CD286</a></li> <li><a href="/wiki/TLR8" class="mw-redirect" title="TLR8">CD288</a></li> <li><a href="/wiki/TLR9" class="mw-redirect" title="TLR9">CD289</a></li> <li><a href="/wiki/TLR10" class="mw-redirect" title="TLR10">CD290</a></li> <li><a href="/wiki/BMPR1A" title="BMPR1A">CD292</a></li> <li><a href="/wiki/BMPR1B" title="BMPR1B">CDw293</a></li> <li><a href="/wiki/CD294" class="mw-redirect" title="CD294">CD294</a></li> <li><a href="/wiki/Leptin_receptor" title="Leptin receptor">CD295</a></li> <li><a href="/wiki/ART4" title="ART4">CD297</a></li> <li><a href="/wiki/ATP1B3" title="ATP1B3">CD298</a></li> <li><a href="/wiki/CLEC4M" title="CLEC4M">CD299</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">301–350</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CD300A" title="CD300A">CD300A</a></li> <li><a href="/wiki/CLEC10A" title="CLEC10A">CD301</a></li> <li><a href="/wiki/CD302" title="CD302">CD302</a></li> <li><a href="/wiki/CLEC4C" title="CLEC4C">CD303</a></li> <li><a href="/wiki/Neuropilin" title="Neuropilin">CD304</a></li> <li><a href="/wiki/LAIR1" title="LAIR1">CD305</a></li> <li><a href="/wiki/LAIR2" title="LAIR2">CD306</a></li> <li><a href="/wiki/FCRL5" title="FCRL5">CD307</a></li> <li><a href="/wiki/Kinase_insert_domain_receptor" title="Kinase insert domain receptor">CD309</a></li> <li><a href="/wiki/EMR2" title="EMR2">CD312</a></li> <li><a href="/wiki/NKG2D" title="NKG2D">CD314</a></li> <li><a href="/wiki/PTGFRN" title="PTGFRN">CD315</a></li> <li><a href="/wiki/IGSF8" title="IGSF8">CD316</a></li> <li><a href="/wiki/Tetherin" title="Tetherin">CD317</a></li> <li><a href="/wiki/CDCP1" title="CDCP1">CD318</a></li> <li><a href="/wiki/CD320" title="CD320">CD320</a></li> <li><a href="/wiki/F11_receptor" title="F11 receptor">CD321</a></li> <li><a href="/wiki/JAM2" title="JAM2">CD322</a></li> <li><a href="/wiki/CDH1_(gene)" class="mw-redirect" title="CDH1 (gene)">CD324</a></li> <li><a href="/wiki/CDH2" class="mw-redirect" title="CDH2">CD325</a></li> <li><a href="/wiki/Epithelial_cell_adhesion_molecule" title="Epithelial cell adhesion molecule">CD326</a></li> <li><a href="/wiki/SIGLEC6" title="SIGLEC6">CD327</a></li> <li><a href="/wiki/SIGLEC7" title="SIGLEC7">CD328</a></li> <li><a href="/wiki/SIGLEC9" title="SIGLEC9">CD329</a></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_1" title="Fibroblast growth factor receptor 1">CD331</a></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_2" title="Fibroblast growth factor receptor 2">CD332</a></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_3" title="Fibroblast growth factor receptor 3">CD333</a></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_4" title="Fibroblast growth factor receptor 4">CD334</a></li> <li><a href="/wiki/NCR1" title="NCR1">CD335</a></li> <li><a href="/wiki/NCR2" title="NCR2">CD336</a></li> <li><a href="/wiki/NCR3" title="NCR3">CD337</a></li> <li><a href="/wiki/ABCG2" title="ABCG2">CD338</a></li> <li><a href="/wiki/JAG1" title="JAG1">CD339</a></li> <li><a href="/wiki/HER2/neu" class="mw-redirect" title="HER2/neu">CD340</a></li> <li><a href="/wiki/FZD4" class="mw-redirect" title="FZD4">CD344</a></li> <li><a href="/wiki/FZD9" class="mw-redirect" title="FZD9">CD349</a></li> <li><a href="/wiki/FZD10" class="mw-redirect" title="FZD10">CD350</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235" /></div><div role="navigation" class="navbox" aria-labelledby="Lipids:_lipoprotein_particle_metabolism298" style="padding:3px"><table class="nowraplinks hlist mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="3"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231" /><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Lipoprotein_metabolism" title="Template:Lipoprotein metabolism"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Lipoprotein_metabolism" title="Template talk:Lipoprotein metabolism"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Lipoprotein_metabolism" title="Special:EditPage/Template:Lipoprotein metabolism"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Lipids:_lipoprotein_particle_metabolism298" style="font-size:114%;margin:0 4em"><a href="/wiki/Lipid" title="Lipid">Lipids</a>: <a href="/wiki/Lipoprotein" title="Lipoprotein">lipoprotein</a> particle metabolism</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Lipoprotein" title="Lipoprotein">Lipoprotein</a> particle classes<br /> and subclasses</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>delivery of <a href="/wiki/Triglyceride" title="Triglyceride">TGs</a>: <a href="/wiki/Chylomicron" title="Chylomicron">Chylomicron</a></li> <li><a href="/wiki/Very_low-density_lipoprotein" title="Very low-density lipoprotein">VLDL</a></li> <li>delivery of <a href="/wiki/Cholesterol" title="Cholesterol">C</a> and <a href="/wiki/Cholesteryl_ester" title="Cholesteryl ester">CE</a>: <a href="/wiki/Intermediate-density_lipoprotein" title="Intermediate-density lipoprotein">IDL</a></li> <li><a href="/wiki/Low-density_lipoprotein" title="Low-density lipoprotein">LDL</a></li> <li>lb LDL</li> <li>sd LDL</li> <li><a href="/wiki/Lipoprotein(a)" title="Lipoprotein(a)">Lp(a)</a></li> <li><a href="/wiki/High-density_lipoprotein" title="High-density lipoprotein">HDL</a></li> <li><a href="/wiki/Remnant_cholesterol" title="Remnant cholesterol">Remnant cholesterol</a></li></ul> </div></td><td class="noviewer navbox-image" rowspan="6" style="width:1px;padding:0 0 0 2px"><div><span typeof="mw:File"><a href="/wiki/File:2512_Chylomicrons_Contain_Triglycerides_Cholesterol_Molecules_and_Other_Lipids.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/ab/2512_Chylomicrons_Contain_Triglycerides_Cholesterol_Molecules_and_Other_Lipids.jpg/350px-2512_Chylomicrons_Contain_Triglycerides_Cholesterol_Molecules_and_Other_Lipids.jpg" decoding="async" width="350" height="280" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/ab/2512_Chylomicrons_Contain_Triglycerides_Cholesterol_Molecules_and_Other_Lipids.jpg/525px-2512_Chylomicrons_Contain_Triglycerides_Cholesterol_Molecules_and_Other_Lipids.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/ab/2512_Chylomicrons_Contain_Triglycerides_Cholesterol_Molecules_and_Other_Lipids.jpg/700px-2512_Chylomicrons_Contain_Triglycerides_Cholesterol_Molecules_and_Other_Lipids.jpg 2x" data-file-width="1228" data-file-height="981" /></a></span></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Apolipoprotein" title="Apolipoprotein">Apolipoproteins</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>APOA <ul><li><a href="/wiki/Apolipoprotein_AI" title="Apolipoprotein AI">1</a></li> <li><a href="/wiki/APOA2" class="mw-redirect" title="APOA2">2</a></li> <li><a href="/wiki/APOA4" title="APOA4">4</a></li> <li><a href="/wiki/APOA5" title="APOA5">5</a></li></ul></li> <li><a href="/wiki/Apolipoprotein_B" title="Apolipoprotein B">APOB</a></li> <li>APOC <ul><li><a href="/wiki/Apolipoprotein_C1" class="mw-redirect" title="Apolipoprotein C1">1</a></li> <li><a href="/wiki/Apolipoprotein_C2" class="mw-redirect" title="Apolipoprotein C2">2</a></li> <li><a href="/wiki/Apolipoprotein_C3" class="mw-redirect" title="Apolipoprotein C3">3</a></li> <li><a href="/wiki/Apolipoprotein_C4" class="mw-redirect" title="Apolipoprotein C4">4</a></li></ul></li> <li><a href="/wiki/Apolipoprotein_D" title="Apolipoprotein D">APOD</a></li> <li><a href="/wiki/Apolipoprotein_E" title="Apolipoprotein E">APOE</a></li> <li><a href="/wiki/Apolipoprotein_H" title="Apolipoprotein H">APOH</a></li> <li><a href="/wiki/Serum_amyloid_A" title="Serum amyloid A">SAA</a> <ul><li><a href="/wiki/Serum_amyloid_A1" title="Serum amyloid A1">SAA1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Extracellular <a href="/wiki/Enzyme" title="Enzyme">enzymes</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Lecithin%E2%80%94cholesterol_acyltransferase" class="mw-redirect" title="Lecithin—cholesterol acyltransferase">LCAT</a></li> <li><a href="/wiki/Hepatic_lipase" title="Hepatic lipase">LIPC</a></li> <li><a href="/wiki/Lipoprotein_lipase" title="Lipoprotein lipase">LPL</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Plant_lipid_transfer_proteins" title="Plant lipid transfer proteins">Lipid transfer proteins</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cholesterylester_transfer_protein" class="mw-redirect" title="Cholesterylester transfer protein">CETP</a></li> <li><a href="/wiki/Microsomal_triglyceride_transfer_protein" title="Microsomal triglyceride transfer protein">MTTP</a></li> <li><a href="/wiki/Phospholipid_transfer_protein" title="Phospholipid transfer protein">PLTP</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cell_surface_receptor" title="Cell surface receptor">Cell surface receptors</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>HDL: <a href="/wiki/SCARB1" title="SCARB1">SCARB1</a></li></ul> <ul><li>IDL: <a href="/wiki/Lipoprotein_receptor-related_protein" title="Lipoprotein receptor-related protein">LRP</a> <ul><li><a class="mw-selflink selflink">LRP1</a></li> <li><a href="/wiki/LRP1B" title="LRP1B">LRP1B</a></li> <li><a href="/wiki/LRP2" title="LRP2">LRP2</a></li> <li><a href="/wiki/LRP3" title="LRP3">LRP3</a></li> <li><a href="/wiki/Low-density_lipoprotein_receptor-related_protein_4" title="Low-density lipoprotein receptor-related protein 4">LRP4</a></li> <li><a href="/wiki/LRP5" title="LRP5">LRP5</a></li> <li><a href="/w/index.php?title=LRP5L&action=edit&redlink=1" class="new" title="LRP5L (page does not exist)">LRP5L</a></li> <li><a href="/wiki/LRP6" title="LRP6">LRP6</a></li> <li><a href="/wiki/Low-density_lipoprotein_receptor-related_protein_8" title="Low-density lipoprotein receptor-related protein 8">LRP8</a></li> <li><a href="/wiki/LRP10" title="LRP10">LRP10</a></li> <li><a href="/wiki/LRP11" title="LRP11">LRP11</a></li> <li><a href="/w/index.php?title=LRP12&action=edit&redlink=1" class="new" title="LRP12 (page does not exist)">LRP12</a></li></ul></li> <li>LDL: <a href="/wiki/LDL_receptor" title="LDL receptor">LDLR</a></li> <li><a href="/wiki/LDL-receptor-related_protein-associated_protein" title="LDL-receptor-related protein-associated protein">LRPAP1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/ATP-binding_cassette_transporter" class="mw-redirect" title="ATP-binding cassette transporter">ATP-binding <br />cassette transporter</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ABCA1" title="ABCA1">ABCA1</a></li> <li><a href="/wiki/ABCG5" title="ABCG5">ABCG5</a></li> <li><a href="/wiki/ABCG8" title="ABCG8">ABCG8</a></li></ul> </div></td></tr></tbody></table></div>    </div><noscript><img src="https://auth.wikimedia.org/loginwiki/wiki/Special:CentralAutoLogin/start?useformat=desktop&type=1x1&usesul3=1" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=LRP1&oldid=1261380816">https://en.wikipedia.org/w/index.php?title=LRP1&oldid=1261380816</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" title="Help:Category">Categories</a>: <ul><li><a href="/wiki/Category:Genes_on_human_chromosome_12" title="Category:Genes on human chromosome 12">Genes on human chromosome 12</a></li><li><a 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