CINXE.COM

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1%;padding:20px 0}.mm-vertical.header-plain #Top_bar .menu > li > ul.mfn-megamenu{width:100%!important;margin:0}.mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li{display:table-cell;float:none!important;width:10%;padding:0 15px;border-right:1px solid rgba(0,0,0,0.05)}.mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li:last-child{border-right-width:0}.mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li.hide-border{border-right-width:0}.mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li a{border-bottom-width:0;padding:9px 15px;line-height:120%}.mm-vertical #Top_bar .menu > li > ul.mfn-megamenu a.mfn-megamenu-title{font-weight:700}.rtl .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li:first-child{border-right-width:0}.rtl .mm-vertical #Top_bar .menu > li > ul.mfn-megamenu > li:last-child{border-right-width:1px}#Header_creative #Top_bar .menu > li > ul.mfn-megamenu{width:980px!important;margin:0}.header-plain:not(.menuo-right) #Header .top_bar_left{width:auto!important}.header-stack.header-center #Top_bar #menu{display:inline-block!important}.header-simple #Top_bar #menu{display:none;height:auto;width:300px;bottom:auto;top:100%;right:1px;position:absolute;margin:0}.header-simple #Header a.responsive-menu-toggle{display:block;right:10px}.header-simple #Top_bar #menu > ul{width:100%;float:left}.header-simple #Top_bar #menu ul li{width:100%;padding-bottom:0;border-right:0;position:relative}.header-simple #Top_bar #menu ul li a{padding:0 20px;margin:0;display:block;height:auto;line-height:normal;border:none}.header-simple #Top_bar #menu ul li a:after{display:none}.header-simple #Top_bar #menu ul li a span{border:none;line-height:44px;display:inline;padding:0}.header-simple #Top_bar #menu ul li.submenu .menu-toggle{display:block;position:absolute;right:0;top:0;width:44px;height:44px;line-height:44px;font-size:30px;font-weight:300;text-align:center;cursor:pointer;color:#444;opacity:0.33}.header-simple #Top_bar #menu ul li.submenu .menu-toggle:after{content:"+"}.header-simple #Top_bar #menu ul li.hover > .menu-toggle:after{content:"-"}.header-simple #Top_bar #menu ul li.hover a{border-bottom:0}.header-simple #Top_bar #menu ul.mfn-megamenu li .menu-toggle{display:none}.header-simple #Top_bar #menu ul li ul{position:relative!important;left:0!important;top:0;padding:0;margin:0!important;width:auto!important;background-image:none}.header-simple #Top_bar #menu ul li ul li{width:100%!important;display:block;padding:0}.header-simple #Top_bar #menu ul li ul li a{padding:0 20px 0 30px}.header-simple #Top_bar #menu ul li ul li a .menu-arrow{display:none}.header-simple #Top_bar #menu ul li ul li a span{padding:0}.header-simple #Top_bar #menu ul li ul li a span:after{display:none!important}.header-simple #Top_bar .menu > li > ul.mfn-megamenu a.mfn-megamenu-title{text-transform:uppercase;font-weight:400}.header-simple #Top_bar .menu > li > ul.mfn-megamenu > li > ul{display:block!important;position:inherit;left:auto;top:auto}.header-simple #Top_bar #menu ul li ul li ul{border-left:0!important;padding:0;top:0}.header-simple #Top_bar #menu ul li ul li ul li a{padding:0 20px 0 40px}.rtl.header-simple #Top_bar #menu{left:1px;right:auto}.rtl.header-simple #Top_bar a.responsive-menu-toggle{left:10px;right:auto}.rtl.header-simple #Top_bar #menu ul li.submenu .menu-toggle{left:0;right:auto}.rtl.header-simple #Top_bar #menu ul li ul{left:auto!important;right:0!important}.rtl.header-simple #Top_bar #menu ul li ul li a{padding:0 30px 0 20px}.rtl.header-simple #Top_bar #menu ul li ul li ul li a{padding:0 40px 0 20px}.menu-highlight #Top_bar .menu > li{margin:0 2px}.menu-highlight:not(.header-creative) #Top_bar .menu > li > a{margin:20px 0;padding:0;-webkit-border-radius:5px;border-radius:5px}.menu-highlight #Top_bar .menu > li > a:after{display:none}.menu-highlight #Top_bar .menu > li > a span:not(.description){line-height:50px}.menu-highlight #Top_bar .menu > li > a span.description{display:none}.menu-highlight.header-stack #Top_bar .menu > li > a{margin:10px 0!important}.menu-highlight.header-stack #Top_bar .menu > li > a span:not(.description){line-height:40px}.menu-highlight.header-transparent #Top_bar .menu > li > a{margin:5px 0}.menu-highlight.header-simple #Top_bar #menu ul li,.menu-highlight.header-creative #Top_bar #menu ul li{margin:0}.menu-highlight.header-simple #Top_bar #menu ul li > a,.menu-highlight.header-creative #Top_bar #menu ul li > a{-webkit-border-radius:0;border-radius:0}.menu-highlight:not(.header-fixed):not(.header-simple) #Top_bar.is-sticky .menu > li > a{margin:10px 0!important;padding:5px 0!important}.menu-highlight:not(.header-fixed):not(.header-simple) #Top_bar.is-sticky .menu > li > a span{line-height:30px!important}.header-modern.menu-highlight.menuo-right .menu_wrapper{margin-right:20px}.menu-line-below #Top_bar .menu > li > a:after{top:auto;bottom:-4px}.menu-line-below #Top_bar.is-sticky .menu > li > a:after{top:auto;bottom:-4px}.menu-line-below-80 #Top_bar:not(.is-sticky) .menu > li > a:after{height:4px;left:10%;top:50%;margin-top:20px;width:80%}.menu-line-below-80-1 #Top_bar:not(.is-sticky) .menu > li > a:after{height:1px;left:10%;top:50%;margin-top:20px;width:80%}.menu-link-color #Top_bar .menu > li > a:after{display:none!important}.menu-arrow-top #Top_bar .menu > li > a:after{background:none repeat scroll 0 0 rgba(0,0,0,0)!important;border-color:#ccc transparent transparent;border-style:solid;border-width:7px 7px 0;display:block;height:0;left:50%;margin-left:-7px;top:0!important;width:0}.menu-arrow-top.header-transparent #Top_bar .menu > li > a:after,.menu-arrow-top.header-plain #Top_bar .menu > li > a:after{display:none}.menu-arrow-top #Top_bar.is-sticky .menu > li > a:after{top:0!important}.menu-arrow-bottom #Top_bar .menu > li > a:after{background:none!important;border-color:transparent transparent #ccc;border-style:solid;border-width:0 7px 7px;display:block;height:0;left:50%;margin-left:-7px;top:auto;bottom:0;width:0}.menu-arrow-bottom.header-transparent #Top_bar .menu > li > a:after,.menu-arrow-bottom.header-plain #Top_bar .menu > li > a:after{display:none}.menu-arrow-bottom #Top_bar.is-sticky .menu > li > a:after{top:auto;bottom:0}.menuo-no-borders #Top_bar .menu > li > a span:not(.description){border-right-width:0}.menuo-no-borders #Header_creative #Top_bar .menu > li > a span{border-bottom-width:0}body.header-creative{padding-left:50px}body.header-creative.header-open{padding-left:250px}body.error404,body.under-construction,body.template-blank{padding-left:0!important}.header-creative.footer-fixed #Footer,.header-creative.footer-sliding #Footer,.header-creative.footer-stick #Footer.is-sticky{box-sizing:border-box;padding-left:50px}.header-open.footer-fixed #Footer,.header-open.footer-sliding #Footer,.header-creative.footer-stick #Footer.is-sticky{padding-left:250px}.header-rtl.header-creative.footer-fixed #Footer,.header-rtl.header-creative.footer-sliding #Footer,.header-rtl.header-creative.footer-stick #Footer.is-sticky{padding-left:0;padding-right:50px}.header-rtl.header-open.footer-fixed #Footer,.header-rtl.header-open.footer-sliding #Footer,.header-rtl.header-creative.footer-stick #Footer.is-sticky{padding-right:250px}#Header_creative{background:#fff;position:fixed;width:250px;height:100%;left:-200px;top:0;z-index:9002;-webkit-box-shadow:2px 0 4px 2px rgba(0,0,0,.15);box-shadow:2px 0 4px 2px rgba(0,0,0,.15)}#Header_creative .container{width:100%}#Header_creative .creative-wrapper{opacity:0;margin-right:50px}#Header_creative a.creative-menu-toggle{display:block;width:34px;height:34px;line-height:34px;font-size:22px;text-align:center;position:absolute;top:10px;right:8px;border-radius:3px}.admin-bar #Header_creative a.creative-menu-toggle{top:42px}#Header_creative #Top_bar{position:static;width:100%}#Header_creative #Top_bar .top_bar_left{width:100%!important;float:none}#Header_creative #Top_bar .top_bar_right{width:100%!important;float:none;height:auto;margin-bottom:35px;text-align:center;padding:0 20px;top:0;-webkit-box-sizing:border-box;-moz-box-sizing:border-box;box-sizing:border-box}#Header_creative #Top_bar .top_bar_right:before{display:none}#Header_creative #Top_bar .top_bar_right_wrapper{top:0}#Header_creative #Top_bar .logo{float:none;text-align:center;margin:15px 0}#Header_creative #Top_bar .menu_wrapper{float:none;margin:0 0 30px}#Header_creative #Top_bar .menu > li{width:100%;float:none;position:relative}#Header_creative #Top_bar .menu > li > a{padding:0;text-align:center}#Header_creative #Top_bar .menu > li > a:after{display:none}#Header_creative #Top_bar .menu > li > a span{border-right:0;border-bottom-width:1px;line-height:38px}#Header_creative #Top_bar .menu li ul{left:100%;right:auto;top:0;box-shadow:2px 2px 2px 0 rgba(0,0,0,0.03);-webkit-box-shadow:2px 2px 2px 0 rgba(0,0,0,0.03)}#Header_creative #Top_bar .menu > li > ul.mfn-megamenu{width:700px!important}#Header_creative #Top_bar .menu > li > ul.mfn-megamenu > li > ul{left:0}#Header_creative #Top_bar .menu li ul li a{padding-top:9px;padding-bottom:8px}#Header_creative #Top_bar .menu li ul li ul{top:0!important}#Header_creative #Top_bar .menu > li > a span.description{display:block;font-size:13px;line-height:28px!important;clear:both}#Header_creative #Top_bar .search_wrapper{left:100%;top:auto;bottom:0}#Header_creative #Top_bar a#header_cart{display:inline-block;float:none;top:3px}#Header_creative #Top_bar a#search_button{display:inline-block;float:none;top:3px}#Header_creative #Top_bar .wpml-languages{display:inline-block;float:none;top:0}#Header_creative #Top_bar .wpml-languages.enabled:hover a.active{padding-bottom:9px}#Header_creative #Top_bar a.button.action_button{display:inline-block;float:none;top:16px;margin:0}#Header_creative #Top_bar .banner_wrapper{display:block;text-align:center}#Header_creative #Top_bar .banner_wrapper img{max-width:100%;height:auto;display:inline-block}#Header_creative #Action_bar{display:none;position:absolute;bottom:0;top:auto;clear:both;padding:0 20px;box-sizing:border-box}#Header_creative #Action_bar .social{float:none;text-align:center;padding:5px 0 15px}#Header_creative #Action_bar .social li{margin-bottom:2px}#Header_creative .social li a{color:rgba(0,0,0,.5)}#Header_creative .social li a:hover{color:#000}#Header_creative .creative-social{position:absolute;bottom:10px;right:0;width:50px}#Header_creative .creative-social li{display:block;float:none;width:100%;text-align:center;margin-bottom:5px}.header-creative .fixed-nav.fixed-nav-prev{margin-left:50px}.header-creative.header-open .fixed-nav.fixed-nav-prev{margin-left:250px}.menuo-last #Header_creative #Top_bar .menu li.last ul{top:auto;bottom:0}.header-open #Header_creative{left:0}.header-open #Header_creative .creative-wrapper{opacity:1;margin:0!important}.header-open #Header_creative .creative-menu-toggle,.header-open #Header_creative .creative-social{display:none}body.header-rtl.header-creative{padding-left:0;padding-right:50px}.header-rtl #Header_creative{left:auto;right:-200px}.header-rtl.nice-scroll #Header_creative{margin-right:10px}.header-rtl #Header_creative .creative-wrapper{margin-left:50px;margin-right:0}.header-rtl #Header_creative a.creative-menu-toggle{left:8px;right:auto}.header-rtl #Header_creative .creative-social{left:0;right:auto}.header-rtl #Footer #back_to_top.sticky{right:125px}.header-rtl #popup_contact{right:70px}.header-rtl #Header_creative #Top_bar .menu li ul{left:auto;right:100%}.header-rtl #Header_creative #Top_bar .search_wrapper{left:auto;right:100%}.header-rtl .fixed-nav.fixed-nav-prev{margin-left:0!important}.header-rtl .fixed-nav.fixed-nav-next{margin-right:50px}body.header-rtl.header-creative.header-open{padding-left:0;padding-right:250px!important}.header-rtl.header-open #Header_creative{left:auto;right:0}.header-rtl.header-open #Footer #back_to_top.sticky{right:325px}.header-rtl.header-open #popup_contact{right:270px}.header-rtl.header-open .fixed-nav.fixed-nav-next{margin-right:250px}#Header_creative.active{left:-1px}.header-rtl #Header_creative.active{left:auto;right:-1px}#Header_creative.active .creative-wrapper{opacity:1;margin:0}.header-creative .vc_row[data-vc-full-width]{padding-left:50px}.header-creative.header-open .vc_row[data-vc-full-width]{padding-left:250px}.header-open .vc_parallax .vc_parallax-inner{left:auto;width:calc(100% - 250px)}.header-open.header-rtl .vc_parallax .vc_parallax-inner{left:0;right:auto}#Header_creative.scroll{height:100%;overflow-y:auto}#Header_creative.scroll:not(.dropdown) .menu li ul{display:none!important}#Header_creative.scroll #Action_bar{position:static}#Header_creative.dropdown{outline:none}#Header_creative.dropdown #Top_bar .menu_wrapper{float:left}#Header_creative.dropdown #Top_bar #menu ul li{position:relative;float:left}#Header_creative.dropdown #Top_bar #menu ul li a:after{display:none}#Header_creative.dropdown #Top_bar #menu ul li a span{line-height:38px;padding:0}#Header_creative.dropdown #Top_bar #menu ul li.submenu .menu-toggle{display:block;position:absolute;right:0;top:0;width:38px;height:38px;line-height:38px;font-size:26px;font-weight:300;text-align:center;cursor:pointer;color:#444;opacity:0.33}#Header_creative.dropdown #Top_bar #menu ul li.submenu .menu-toggle:after{content:"+"}#Header_creative.dropdown #Top_bar #menu ul li.hover > .menu-toggle:after{content:"-"}#Header_creative.dropdown #Top_bar #menu ul li.hover a{border-bottom:0}#Header_creative.dropdown #Top_bar #menu ul.mfn-megamenu li .menu-toggle{display:none}#Header_creative.dropdown #Top_bar #menu ul li ul{position:relative!important;left:0!important;top:0;padding:0;margin-left:0!important;width:auto!important;background-image:none}#Header_creative.dropdown #Top_bar #menu ul li ul li{width:100%!important}#Header_creative.dropdown #Top_bar #menu ul li ul li a{padding:0 10px;text-align:center}#Header_creative.dropdown #Top_bar #menu ul li ul li a .menu-arrow{display:none}#Header_creative.dropdown #Top_bar #menu ul li ul li a span{padding:0}#Header_creative.dropdown #Top_bar #menu ul li ul li a span:after{display:none!important}#Header_creative.dropdown #Top_bar .menu > li > ul.mfn-megamenu a.mfn-megamenu-title{text-transform:uppercase;font-weight:400}#Header_creative.dropdown #Top_bar .menu > li > ul.mfn-megamenu > li > ul{display:block!important;position:inherit;left:auto;top:auto}#Header_creative.dropdown #Top_bar #menu ul li ul li ul{border-left:0!important;padding:0;top:0}#Header_creative{transition:left .5s ease-in-out,right .5s ease-in-out}#Header_creative .creative-wrapper{transition:opacity .5s ease-in-out,margin 0s ease-in-out .5s}#Header_creative.active .creative-wrapper{transition:opacity .5s ease-in-out,margin 0s ease-in-out}}@media only screen and (min-width:1130px){#Top_bar.is-sticky{position:fixed!important;width:100%;left:0;top:-60px;height:60px;z-index:701;background:#fff;opacity:.97;filter:alpha(opacity = 97);-webkit-box-shadow:0 2px 5px 0 rgba(0,0,0,0.1);-moz-box-shadow:0 2px 5px 0 rgba(0,0,0,0.1);box-shadow:0 2px 5px 0 rgba(0,0,0,0.1)}.layout-boxed.header-boxed #Top_bar.is-sticky{max-width:1130px;left:50%;-webkit-transform:translateX(-50%);transform:translateX(-50%)}.layout-boxed.header-boxed.nice-scroll #Top_bar.is-sticky{margin-left:-5px}#Top_bar.is-sticky .top_bar_left,#Top_bar.is-sticky .top_bar_right,#Top_bar.is-sticky .top_bar_right:before{background:none}#Top_bar.is-sticky .top_bar_right{top:-4px;height:auto}#Top_bar.is-sticky .top_bar_right_wrapper{top:15px}.header-plain #Top_bar.is-sticky .top_bar_right_wrapper{top:0}#Top_bar.is-sticky .logo{width:auto;margin:0 30px 0 20px;padding:0}#Top_bar.is-sticky #logo{padding:5px 0!important;height:50px!important;line-height:50px!important}.logo-no-sticky-padding #Top_bar.is-sticky #logo{height:60px!important;line-height:60px!important}#Top_bar.is-sticky #logo img.logo-main{display:none}#Top_bar.is-sticky #logo img.logo-sticky{display:inline;max-height:35px}#Top_bar.is-sticky .menu_wrapper{clear:none}#Top_bar.is-sticky .menu_wrapper .menu > li > a{padding:15px 0}#Top_bar.is-sticky .menu > li > a,#Top_bar.is-sticky .menu > li > a span{line-height:30px}#Top_bar.is-sticky .menu > li > a:after{top:auto;bottom:-4px}#Top_bar.is-sticky .menu > li > a span.description{display:none}#Top_bar.is-sticky .secondary_menu_wrapper,#Top_bar.is-sticky .banner_wrapper{display:none}.header-overlay #Top_bar.is-sticky{display:none}.sticky-dark #Top_bar.is-sticky{background:rgba(0,0,0,.8)}.sticky-dark #Top_bar.is-sticky #menu{background:rgba(0,0,0,.8)}.sticky-dark #Top_bar.is-sticky .menu > li > a{color:#fff}.sticky-dark #Top_bar.is-sticky .top_bar_right a{color:rgba(255,255,255,.5)}.sticky-dark #Top_bar.is-sticky .wpml-languages a.active,.sticky-dark #Top_bar.is-sticky .wpml-languages ul.wpml-lang-dropdown{background:rgba(0,0,0,0.3);border-color:rgba(0,0,0,0.1)}}@media only screen and (min-width:768px) and (max-width:1130px){.header_placeholder{height:0!important}}@media only screen and (max-width:1129px){#Top_bar #menu{display:none;height:auto;width:100%;bottom:auto;top:100%;right:1px;position:absolute;margin:0}#Top_bar a.responsive-menu-toggle{display:block}#Top_bar #menu > ul{width:100%;float:left}#Top_bar #menu ul li{width:100%;padding-bottom:0;border-right:0;position:relative}#Top_bar #menu ul li a{padding:0 25px;margin:0;display:block;height:auto;line-height:normal;border:none}#Top_bar #menu ul li a:after{display:none}#Top_bar #menu ul li a 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class="ubermenu-target-title ubermenu-target-text">ME220</span><span class="ubermenu-target-divider"> – </span><span class="ubermenu-target-description ubermenu-target-text">Compact 1 to 8 sample batch processing</span></a></li><li id="menu-item-26911" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-26911 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-3" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/ml230-focused-ultrasonicator-500656"><span class="ubermenu-target-title ubermenu-target-text">ML230</span><span class="ubermenu-target-divider"> – </span><span class="ubermenu-target-description ubermenu-target-text">Parallel sample processing, up to 8 samples</span></a></li><li id="menu-item-26912" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-26912 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-3" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/e220evolution-focused-ultrasonicator-500429"><span class="ubermenu-target-title ubermenu-target-text">E220<i>evolution</i></span><span class="ubermenu-target-divider"> – </span><span class="ubermenu-target-description ubermenu-target-text">High power, 1 to 8 sample batch processing</span></a></li><li id="menu-item-26913" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-26913 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-3" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/e220-focused-ultrasonicator-500239"><span class="ubermenu-target-title ubermenu-target-text">E220</span><span class="ubermenu-target-divider"> – </span><span class="ubermenu-target-description ubermenu-target-text">High power, 1 to 96 sample batch preparation system</span></a></li></ul></li><li id="menu-item-26914" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-has-children ubermenu-item-26914 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2 ubermenu-has-submenu-drop ubermenu-has-submenu-flyout" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/products-services/instruments/high-throughput-focused-ultrasonicators"><span class="ubermenu-target-title ubermenu-target-text">High-throughput Focused-ultrasonicators</span><i class='ubermenu-sub-indicator fas fa-angle-down'></i></a><ul class="ubermenu-submenu ubermenu-submenu-id-26914 ubermenu-submenu-type-flyout ubermenu-submenu-drop ubermenu-submenu-align-left_edge_item ubermenu-submenu-retractor-top" ><li class="ubermenu-retractor ubermenu-retractor-mobile"><i class="fas fa-times"></i> Close</li><li id="menu-item-26915" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-26915 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-3" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/le220-plus-focused-ultrasonicator-500569"><span class="ubermenu-target-title ubermenu-target-text">LE220-plus</span><span class="ubermenu-target-divider"> – </span><span class="ubermenu-target-description ubermenu-target-text">High-throughput, 1 to 96 tube capacity</span></a></li><li id="menu-item-26916" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-26916 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-3" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/le220r-plus-focused-ultrasonicator-500578"><span class="ubermenu-target-title ubermenu-target-text">LE220R-plus</span><span class="ubermenu-target-divider"> – </span><span class="ubermenu-target-description ubermenu-target-text">Robotic version of the LE220-plus</span></a></li><li id="menu-item-30065" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-30065 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-3" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="https://www.covaris.com/le220rsc-focused-ultrasonicator"><span class="ubermenu-target-title ubermenu-target-text">LE220Rsc</span></a></li></ul></li><li id="menu-item-26917" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-has-children ubermenu-item-26917 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2 ubermenu-has-submenu-drop ubermenu-has-submenu-flyout" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/products-services/instruments/on-deck-automation-focused-ultrasonicators"><span class="ubermenu-target-title ubermenu-target-text">On-Deck Automation Focused-ultrasonicators</span><i class='ubermenu-sub-indicator fas fa-angle-down'></i></a><ul class="ubermenu-submenu ubermenu-submenu-id-26917 ubermenu-submenu-type-flyout ubermenu-submenu-drop ubermenu-submenu-align-left_edge_item ubermenu-submenu-retractor-top" ><li class="ubermenu-retractor ubermenu-retractor-mobile"><i class="fas fa-times"></i> Close</li><li id="menu-item-26918" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-26918 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-3" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/r230-focused-ultrasonicator"><span class="ubermenu-target-title ubermenu-target-text">R230</span><span class="ubermenu-target-divider"> – </span><span class="ubermenu-target-description ubermenu-target-text">On-deck, next generation Focused-ultrasonicator</span></a></li></ul></li><li id="menu-item-26919" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-has-children ubermenu-item-26919 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2 ubermenu-has-submenu-drop ubermenu-has-submenu-flyout" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/products-services/instruments/cryoprep"><span class="ubermenu-target-title ubermenu-target-text">cryoPREP<sup>®</sup> Extraction Systems</span><i class='ubermenu-sub-indicator fas fa-angle-down'></i></a><ul class="ubermenu-submenu ubermenu-submenu-id-26919 ubermenu-submenu-type-flyout ubermenu-submenu-drop ubermenu-submenu-align-left_edge_item ubermenu-submenu-retractor-top" ><li class="ubermenu-retractor ubermenu-retractor-mobile"><i class="fas fa-times"></i> Close</li><li id="menu-item-26920" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-26920 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-3" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/cp01-cryoprep-manual-dry-pulverizer-500230"><span class="ubermenu-target-title ubermenu-target-text">CP01 Manual Pulverizer</span><span class="ubermenu-target-divider"> – </span><span class="ubermenu-target-description ubermenu-target-text">For Tissues 15 mg to 2 g</span></a></li><li id="menu-item-26921" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-26921 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-3" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/cp02-cryoprep-automated-dry-pulverizer-110v-500001"><span class="ubermenu-target-title ubermenu-target-text">CP02 Automated Dry Pulverizer</span></a></li><li id="menu-item-26922" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-26922 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-3" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/cp03-cryoprep-manual-dry-pulverizer-500049"><span class="ubermenu-target-title ubermenu-target-text">CP03 Manual Pulverizer</span><span class="ubermenu-target-divider"> – </span><span class="ubermenu-target-description ubermenu-target-text">For Tissues 2 to 5 g</span></a></li></ul></li><li id="menu-item-26923" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-26923 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/products-services/instruments/sonolab-software"><span class="ubermenu-target-title ubermenu-target-text">SonoLab Software</span></a></li></ul></li><li id="menu-item-26927" class="scroll-menu-top ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-has-children ubermenu-item-26927 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-1 ubermenu-has-submenu-drop ubermenu-has-submenu-flyout" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/products-services/kits-reagents"><span class="ubermenu-target-title ubermenu-target-text">Kits & Reagents</span><i class='ubermenu-sub-indicator fas fa-angle-down'></i></a><ul class="ubermenu-submenu ubermenu-submenu-id-26927 ubermenu-submenu-type-flyout ubermenu-submenu-drop ubermenu-submenu-align-left_edge_item ubermenu-submenu-retractor-top" ><li class="ubermenu-retractor ubermenu-retractor-mobile"><i class="fas fa-times"></i> Close</li><li id="menu-item-42286" class="ubermenu-item ubermenu-item-type-post_type ubermenu-item-object-page ubermenu-item-42286 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="https://www.covaris.com/trucover-library-prep"><span class="ubermenu-target-title ubermenu-target-text">truCOVER Library Prep Kits</span></a></li><li id="menu-item-41083" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-41083 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="https://www.covaris.com/truprep-protein/"><span class="ubermenu-target-title ubermenu-target-text">truPREP® Protein Kits</span></a></li><li id="menu-item-35108" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-35108 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="https://www.covaris.com/truxtrac-ffpe-na-auto-96-kits"><span class="ubermenu-target-title ubermenu-target-text">truXTRAC® FFPE SMART Solutions</span></a></li><li id="menu-item-26931" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-26931 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/products-services/kits-reagents/cryoprep-0"><span class="ubermenu-target-title ubermenu-target-text">cryoPREP Starter Kits</span><span class="ubermenu-target-divider"> – </span><span class="ubermenu-target-description ubermenu-target-text">cryoPREP Sample Tubes & Holders</span></a></li><li id="menu-item-26933" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-26933 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/products-services/kits-reagents/nucleic-acids-shearing-kits-and-buffers"><span class="ubermenu-target-title ubermenu-target-text">Nucleic Acids Shearing Kits and Buffers</span><span class="ubermenu-target-divider"> – </span><span class="ubermenu-target-description ubermenu-target-text">truSHEAR, truPOP, DNA Verification Kits</span></a></li><li id="menu-item-26929" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-26929 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/products-services/kits-reagents/truxtrac-ffpe-kits"><span class="ubermenu-target-title ubermenu-target-text">Other truXTRAC<sup>®</sup> FFPE Kits</span><span class="ubermenu-target-divider"> – </span><span class="ubermenu-target-description ubermenu-target-text">FFPE Biomolecule Extraction Kits</span></a></li><li id="menu-item-26934" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-26934 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/products-services/kits-reagents/truxtrac-other"><span class="ubermenu-target-title ubermenu-target-text">Other truXTRAC<sup>®</sup> Kits</span><span class="ubermenu-target-divider"> – </span><span class="ubermenu-target-description ubermenu-target-text">cfDNA, DBS, MALDI-TOF</span></a></li><li id="menu-item-26935" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-26935 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/products-services/kits-reagents/protein-extraction-buffers"><span class="ubermenu-target-title ubermenu-target-text">Protein Extraction Buffers</span><span class="ubermenu-target-divider"> – </span><span class="ubermenu-target-description ubermenu-target-text">Native, Total Protein, & Detergent-free Buffers</span></a></li><li id="menu-item-26930" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-26930 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/products-services/kits-reagents/truchip"><span class="ubermenu-target-title ubermenu-target-text">truChIP<sup>®</sup></span><span class="ubermenu-target-divider"> – </span><span class="ubermenu-target-description ubermenu-target-text">Chromatin Shearing Kits</span></a></li></ul></li><li id="menu-item-26936" class="scroll-menu-top ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-has-children ubermenu-item-26936 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-1 ubermenu-has-submenu-drop ubermenu-has-submenu-flyout" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/products-services/consumables"><span class="ubermenu-target-title ubermenu-target-text">Consumables – Tubes and Vials</span><i class='ubermenu-sub-indicator fas fa-angle-down'></i></a><ul class="ubermenu-submenu ubermenu-submenu-id-26936 ubermenu-submenu-type-flyout ubermenu-submenu-drop ubermenu-submenu-align-left_edge_item ubermenu-submenu-retractor-top" ><li class="ubermenu-retractor ubermenu-retractor-mobile"><i class="fas fa-times"></i> Close</li><li id="menu-item-26938" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-26938 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/products-services/consumables/afa-tube"><span class="ubermenu-target-title ubermenu-target-text">AFA-TUBE</span><span class="ubermenu-target-divider"> – </span><span class="ubermenu-target-description ubermenu-target-text">Laser etched polymer vessel for high-throughput workflows</span></a></li><li id="menu-item-26939" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-26939 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/products-services/consumables/microtube"><span class="ubermenu-target-title ubermenu-target-text">microTUBE</span><span class="ubermenu-target-divider"> – </span><span class="ubermenu-target-description ubermenu-target-text">Small sample volumes, 130 µl or less</span></a></li><li id="menu-item-26940" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-26940 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/products-services/consumables/millitube"><span class="ubermenu-target-title ubermenu-target-text">milliTUBE</span><span class="ubermenu-target-divider"> – </span><span class="ubermenu-target-description ubermenu-target-text">1 ml or 2 ml sample volume. Good for chromatin shearing</span></a></li><li id="menu-item-26942" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-26942 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/products-services/consumables/other-afa-tubes"><span class="ubermenu-target-title ubermenu-target-text">Other AFA-TUBEs</span></a></li><li id="menu-item-26943" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-26943 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/afa-process-vessels/"><span class="ubermenu-target-title ubermenu-target-text">AFA Process Vessels</span><span class="ubermenu-target-divider"> – </span><span class="ubermenu-target-description ubermenu-target-text">High power, low temperature processing</span></a></li><li id="menu-item-26944" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-26944 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/products-services/consumables/g-tube"><span class="ubermenu-target-title ubermenu-target-text">g-TUBE</span><span class="ubermenu-target-divider"> – </span><span class="ubermenu-target-description ubermenu-target-text">DNA shearing fragments 6 to 20 kb</span></a></li></ul></li><li id="menu-item-26945" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-has-children ubermenu-item-26945 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-1 ubermenu-has-submenu-drop ubermenu-has-submenu-flyout" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/products-services/cryoprep-consumables"><span class="ubermenu-target-title ubermenu-target-text">cryoPREP Consumables</span><i class='ubermenu-sub-indicator fas fa-angle-down'></i></a><ul class="ubermenu-submenu ubermenu-submenu-id-26945 ubermenu-submenu-type-flyout ubermenu-submenu-drop ubermenu-submenu-align-left_edge_item ubermenu-submenu-retractor-top" ><li class="ubermenu-retractor ubermenu-retractor-mobile"><i class="fas fa-times"></i> Close</li><li id="menu-item-26947" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-26947 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/products-services/cryoprep-consumables/tissuetube"><span class="ubermenu-target-title ubermenu-target-text">tissueTUBE</span><span class="ubermenu-target-divider"> – </span><span class="ubermenu-target-description ubermenu-target-text">Tissue processing devices</span></a></li></ul></li><li id="menu-item-26949" class="scroll-menu-top ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-has-children ubermenu-item-26949 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-1 ubermenu-has-submenu-drop ubermenu-has-submenu-flyout" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/products-services/accessories"><span class="ubermenu-target-title ubermenu-target-text">Accessories</span><i class='ubermenu-sub-indicator fas fa-angle-down'></i></a><ul class="ubermenu-submenu ubermenu-submenu-id-26949 ubermenu-submenu-type-flyout ubermenu-submenu-drop ubermenu-submenu-align-left_edge_item ubermenu-submenu-retractor-top" ><li class="ubermenu-retractor ubermenu-retractor-mobile"><i class="fas fa-times"></i> Close</li><li id="menu-item-26952" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-26952 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/products-services/accessories/automation-accessories"><span class="ubermenu-target-title ubermenu-target-text">Automation Accessories</span></a></li><li id="menu-item-41270" class="ubermenu-item ubermenu-item-type-post_type ubermenu-item-object-page ubermenu-item-41270 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="https://www.covaris.com/r230-accessories"><span class="ubermenu-target-title ubermenu-target-text">R230 Accessories</span></a></li><li id="menu-item-26953" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-26953 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/products-services/accessories/m220-accessories"><span class="ubermenu-target-title ubermenu-target-text">M220 Accessories</span></a></li><li id="menu-item-26954" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-26954 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/products-services/accessories/me220-accessories"><span class="ubermenu-target-title ubermenu-target-text">ME220 Accessories</span></a></li><li id="menu-item-30718" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-30718 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/products-services/accessories/ml230-accessories"><span class="ubermenu-target-title ubermenu-target-text">ML230 Accessories</span></a></li><li id="menu-item-26955" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom 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href="/application-technical-notes?filter_tag=AFA-TUBE/Automation"><span class="ubermenu-target-title ubermenu-target-text">AFA-TUBE/Automation</span></a></li><li id="menu-item-27003" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-27003 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-3" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/application-technical-notes?filter_tag=Cell%20Lysis"><span class="ubermenu-target-title ubermenu-target-text">Cell Lysis</span></a></li><li id="menu-item-27004" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-27004 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-3" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/application-technical-notes?filter_tag=Covaris%20Best%20Practices"><span class="ubermenu-target-title ubermenu-target-text">Covaris Best 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ubermenu-item-27007 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-3" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/application-technical-notes?filter_tag=Extraction%20from%20FFPE%20Samples"><span class="ubermenu-target-title ubermenu-target-text">Extraction from FFPE Samples</span></a></li><li id="menu-item-42323" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-42323 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-3" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="https://www.covaris.com/application-technical-notes/?filter_tag=NGS%20Library%20Preparation"><span class="ubermenu-target-title ubermenu-target-text">NGS Library Preparation</span></a></li><li id="menu-item-27002" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-27002 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-3" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/application-technical-notes?filter_tag=NGS/DNA%20Shearing%20and%20Fragmentation"><span class="ubermenu-target-title ubermenu-target-text">NGS/DNA Shearing and Fragmentation</span></a></li><li id="menu-item-32692" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-32692 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-3" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/application-technical-notes?filter_tag=Proteomics"><span class="ubermenu-target-title ubermenu-target-text">Proteomics</span></a></li></ul></li><li id="menu-item-39002" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-39002 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="https://www.covaris.com/instrument-cleaning-protocols"><span class="ubermenu-target-title ubermenu-target-text">Instrument Cleaning Protocols</span></a></li><li id="menu-item-27009" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-27009 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/publications/"><span class="ubermenu-target-title ubermenu-target-text">Posters</span></a></li><li id="menu-item-27010" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-has-children ubermenu-item-27010 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2 ubermenu-has-submenu-drop ubermenu-has-submenu-flyout" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/videos/"><span class="ubermenu-target-title ubermenu-target-text">Videos</span><i class='ubermenu-sub-indicator fas fa-angle-down'></i></a><ul class="ubermenu-submenu ubermenu-submenu-id-27010 ubermenu-submenu-type-flyout ubermenu-submenu-drop ubermenu-submenu-align-left_edge_item ubermenu-submenu-retractor-top" ><li class="ubermenu-retractor ubermenu-retractor-mobile"><i class="fas fa-times"></i> Close</li><li id="menu-item-27013" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-27013 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-3" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/videos?filter_tag=AFA%20Technology"><span class="ubermenu-target-title ubermenu-target-text">AFA Technology</span></a></li><li id="menu-item-27012" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-27012 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-3" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="https://www.covaris.com/videos?filter_tag=Automation"><span class="ubermenu-target-title ubermenu-target-text">Automation</span></a></li><li id="menu-item-27016" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-27016 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-3" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/videos?filter_tag=Chromatin%20and%20ChIP"><span class="ubermenu-target-title ubermenu-target-text">Chromatin and ChIP</span></a></li><li id="menu-item-27017" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-27017 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-3" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/videos?filter_tag=DNA/RNA%20Shearing%20for%20NGS"><span class="ubermenu-target-title ubermenu-target-text">DNA/RNA Shearing for NGS</span></a></li><li id="menu-item-27015" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-27015 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-3" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/videos?filter_tag=FFPE%20Extraction"><span class="ubermenu-target-title ubermenu-target-text">FFPE Extraction</span></a></li><li id="menu-item-27014" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-27014 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-3" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/videos?filter_tag=Instruments"><span class="ubermenu-target-title ubermenu-target-text">Instruments</span></a></li></ul></li></ul></li><li id="menu-item-27019" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-has-children ubermenu-item-27019 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-1 ubermenu-has-submenu-drop ubermenu-has-submenu-flyout" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/product-documents/"><span class="ubermenu-target-title ubermenu-target-text">Product Documents</span><i class='ubermenu-sub-indicator fas fa-angle-down'></i></a><ul class="ubermenu-submenu ubermenu-submenu-id-27019 ubermenu-submenu-type-flyout ubermenu-submenu-drop ubermenu-submenu-align-left_edge_item ubermenu-submenu-retractor-top" ><li class="ubermenu-retractor ubermenu-retractor-mobile"><i class="fas fa-times"></i> Close</li><li id="menu-item-27021" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-has-children ubermenu-item-27021 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2 ubermenu-has-submenu-drop ubermenu-has-submenu-flyout" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/brochures/"><span class="ubermenu-target-title ubermenu-target-text">Brochures</span><i class='ubermenu-sub-indicator fas fa-angle-down'></i></a><ul class="ubermenu-submenu ubermenu-submenu-id-27021 ubermenu-submenu-type-flyout ubermenu-submenu-drop ubermenu-submenu-align-left_edge_item ubermenu-submenu-retractor-top" ><li class="ubermenu-retractor ubermenu-retractor-mobile"><i class="fas fa-times"></i> Close</li><li id="menu-item-27023" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-27023 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-3" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/brochures?filter_tag=Instruments"><span class="ubermenu-target-title ubermenu-target-text">Instruments</span></a></li><li id="menu-item-27024" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-27024 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-3" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/brochures?filter_tag=Kits%20and%20Reagents"><span class="ubermenu-target-title ubermenu-target-text">Kits & Reagents</span></a></li><li id="menu-item-27025" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-27025 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-3" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/brochures?filter_tag=Consumables"><span class="ubermenu-target-title ubermenu-target-text">Consumables</span></a></li></ul></li><li id="menu-item-27026" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-has-children ubermenu-item-27026 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2 ubermenu-has-submenu-drop ubermenu-has-submenu-flyout" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/product-inserts-user-manuals/"><span class="ubermenu-target-title ubermenu-target-text">Product Inserts & User Manuals</span><i class='ubermenu-sub-indicator fas fa-angle-down'></i></a><ul class="ubermenu-submenu ubermenu-submenu-id-27026 ubermenu-submenu-type-flyout ubermenu-submenu-drop ubermenu-submenu-align-left_edge_item ubermenu-submenu-retractor-top" ><li class="ubermenu-retractor ubermenu-retractor-mobile"><i class="fas fa-times"></i> Close</li><li id="menu-item-41252" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-41252 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-3" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/product-inserts-user-manuals?filter_tag=Product%20Information%20Sheets"><span class="ubermenu-target-title ubermenu-target-text">Accessories</span></a></li><li id="menu-item-27028" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom 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href="/product-inserts-user-manuals?filter_tag=microTUBEs"><span class="ubermenu-target-title ubermenu-target-text">microTUBES</span></a></li><li id="menu-item-27031" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-27031 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-3" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/product-inserts-user-manuals?filter_tag=AFA-TUBEs"><span class="ubermenu-target-title ubermenu-target-text">AFA-TUBEs</span></a></li><li id="menu-item-27032" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-27032 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-3" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/product-inserts-user-manuals?filter_tag=tissueTUBEs"><span class="ubermenu-target-title ubermenu-target-text">tissueTUBEs</span></a></li><li id="menu-item-27033" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-27033 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-3" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/product-inserts-user-manuals?filter_tag=Flow%20Cells%20and%20Process%20Vessels"><span class="ubermenu-target-title ubermenu-target-text">Flow Cells & Process Vessels</span></a></li><li id="menu-item-27034" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-27034 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-3" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/product-inserts-user-manuals?filter_tag=Software"><span class="ubermenu-target-title ubermenu-target-text">Software</span></a></li></ul></li><li id="menu-item-27035" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-27035 ubermenu-item-auto 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ubermenu-item-layout-text_only" href="/software-downloads/"><span class="ubermenu-target-title ubermenu-target-text">Software Downloads</span><i class='ubermenu-sub-indicator fas fa-angle-down'></i></a><ul class="ubermenu-submenu ubermenu-submenu-id-27036 ubermenu-submenu-type-flyout ubermenu-submenu-drop ubermenu-submenu-align-left_edge_item ubermenu-submenu-retractor-top" ><li class="ubermenu-retractor ubermenu-retractor-mobile"><i class="fas fa-times"></i> Close</li><li id="menu-item-27038" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-27038 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-2" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/m-series/"><span class="ubermenu-target-title ubermenu-target-text">M-Series</span></a></li><li id="menu-item-27039" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-27039 ubermenu-item-auto 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ubermenu-has-submenu-flyout" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="#" tabindex="0"><span class="ubermenu-target-title ubermenu-target-text">Company</span><i class='ubermenu-sub-indicator fas fa-angle-down'></i></a><ul class="ubermenu-submenu ubermenu-submenu-id-27043 ubermenu-submenu-type-flyout ubermenu-submenu-drop ubermenu-submenu-align-left_edge_item ubermenu-submenu-retractor-top" ><li class="ubermenu-retractor ubermenu-retractor-mobile"><i class="fas fa-times"></i> Close</li><li id="menu-item-27044" class="ubermenu-item ubermenu-item-type-custom ubermenu-item-object-custom ubermenu-item-27044 ubermenu-item-auto ubermenu-item-normal ubermenu-item-level-1" ><a class="ubermenu-target ubermenu-item-layout-default ubermenu-item-layout-text_only" href="/about-covaris-2/"><span class="ubermenu-target-title ubermenu-target-text">About Covaris</span></a></li><li id="menu-item-42333" class="ubermenu-item ubermenu-item-type-custom 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style="padding: 0px;"> <div class="content_wrapper clearfix"> <div class="sections_group"> <div class="entry-content" itemprop="mainContentOfPage"> <div data-vc-full-width="true" data-vc-full-width-init="false" class="vc_row wpb_row vc_row-fluid shearing_banner vc_custom_1583475962885 vc_row-has-fill"><div class="wpb_column vc_column_container vc_col-sm-12"><div class="vc_column-inner vc_custom_1583475591897"><div class="wpb_wrapper"><h1 style="color: #ffffff;text-align: center" class="vc_custom_heading vc_do_custom_heading vc_custom_1646291109664" >FFPE Paraffin Removal and Extraction</h1><div style="color: #ffffff;text-align: center" class="vc_custom_heading vc_do_custom_heading h3" >Covaris AFA® technology provides a patented and unique methodology to efficiently emulsify and remove paraffin from an FFPE sample, freeing and exposing more tissue. This allows superior accessibility to the tissue during biomolecule extraction, enabling a higher quality purification.</div></div></div></div></div><div class="vc_row-full-width vc_clearfix"></div><div class="vc_row wpb_row vc_row-fluid cmspage_menu vc_custom_1583489874470 vc_column-gap-20"><div class="common-pages-left-container PrdMenu clearfix wpb_column vc_column_container vc_col-sm-3 vc_col-has-fill"><div class="vc_column-inner vc_custom_1583479740629"><div class="wpb_wrapper"><h4 style="color: #ffffff;text-align: left" class="vc_custom_heading vc_do_custom_heading custom_h4 vc_custom_1719423986902" >Contents</h4> <div class="wpb_text_column wpb_content_element" > <div class="wpb_wrapper"> <ul id="shearing-sidebar"> <li class="active"><a style="cursor: pointer; display: block; text-decoration: none;" href="#overview">Overview</a></li> <li><a style="cursor: pointer; display: block; text-decoration: none;" href="#ngs_quality_dna_and_rna">Simultaneously Extract NGS-quality DNA and RNA from FFPE Tissue Samples<br /> </a></li> <li class=""><a style="cursor: pointer; display: block; text-decoration: none;" href="#rna_results">High-Quality RNA Results<br /> </a></li> <li class=""><a style="cursor: pointer; display: block; text-decoration: none;" href="#diagnostic_decisions">Empowering improved diagnostic decisions through an automated clinical FFPE extraction workflow</a></li> <li><a href="#ffpe_tissue_extraction">Protein Extraction from FFPE Tissue</a></li> <li class=""><a style="cursor: pointer; display: block; text-decoration: none;" href="#featured_product">Featured Products</a></li> <li class=""><a style="cursor: pointer; display: grid; text-decoration: none;" href="#resources">Resources</a></li> <li class=""><a style="cursor: pointer; display: grid; text-decoration: none;" href="#references">References</a></li> </ul> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-9"><div class="vc_column-inner vc_custom_1580898106712"><div class="wpb_wrapper"><div id="overview" class="vc_row wpb_row vc_inner vc_row-fluid vc_custom_1583755521790"><div class="wpb_column vc_column_container vc_col-sm-12"><div class="vc_column-inner"><div class="wpb_wrapper"><h2 style="color: #2d3e51;text-align: left" class="vc_custom_heading vc_do_custom_heading" >Extract high-quality DNA, RNA, and Proteins from FFPE tissue samples</h2> <div class="wpb_text_column wpb_content_element vc_custom_1729773245564 instrument_bullet_list" > <div class="wpb_wrapper"> <p class="custom_h5">Formalin fixation and paraffin embedding (FFPE) is the most common method of preserving and archiving solid tissues. The extraction of biomolecules from FFPE tissue samples can often be challenging due to the quality of the stored sample. Covaris offers a range of FFPE extraction kits for your specific biomolecule extraction workflow needs, including both bead-based and column kits.</p> <p class="custom_h5">Covaris FFPE extraction, powered by Adaptive Focused Acoustics® (AFA®) technology enables:</p> <ul> <li>Superior extraction for low mass inputs from slides and cores</li> <li>Hands-free paraffin removal – no toxic organic solvents required</li> <li>Extraction of longer RNA with high DV200 scores – detect rare fusion events</li> <li>Reduced variability with a simplified and standardized workflow</li> <li>Semi-automated, high-throughput processing</li> </ul> <p> </p> <p><a class="image-popup-no-margins" href="https://www.covaris.com/wp/wp-content/uploads/2020/06/FFPE_ParaffinRemoval-300x300.jpg"><img class="aligncenter wp-image-27661 size-medium" src="https://www.covaris.com/wp/wp-content/uploads/2020/06/FFPE_ParaffinRemoval-300x300.jpg" alt="Covaris Adaptive Focused Acoustics (AFA) technology for precise biomolecule extraction from FFPE tissue samples" width="300" height="300" /></a></p> </div> </div> </div></div></div></div><div id="benifits" class="vc_row wpb_row vc_inner vc_row-fluid instrument_lev_1_quote vc_custom_1583919805090"><div class="wpb_column vc_column_container vc_col-sm-12"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element" > <div class="wpb_wrapper"> <p><img class="aligncenter" src="/wp/wp-content/uploads/2020/02/quote.png"" /></p> </div> </div> <div style="color: #2c2c2c;text-align: center" class="vc_custom_heading vc_do_custom_heading h5" ><em>“Deparaffinization of FFPE tissue in the Covaris E220 allows us to avoid the use of xylene in our small laboratory space. Paraffin is efficiently removed from FFPE samples, removing any concerns of clogging columns, contaminating instrumentation or suppressing ionization.”</em></div><div style="color: #2d3e51;text-align: center" class="vc_custom_heading vc_do_custom_heading h6" ><em>Dr. J. Chapman</em></div><p style="color: #2d3e51;text-align: center" class="vc_custom_heading vc_do_custom_heading vc_custom_1583919896653" >Laboratory Director, Memorial Sloan-Kettering</p></div></div></div></div><div id="ngs_quality_dna_and_rna" class="vc_row wpb_row vc_inner vc_row-fluid vc_custom_1586371553250"><div class="wpb_column vc_column_container vc_col-sm-12"><div class="vc_column-inner"><div class="wpb_wrapper"><h2 style="color: #2d3e51;text-align: left" class="vc_custom_heading vc_do_custom_heading" >Simultaneously Extract NGS-quality DNA and RNA from FFPE Tissue Samples</h2> <div class="wpb_text_column wpb_content_element vc_custom_1729773170593 custom_h5 mobile_padding" > <div class="wpb_wrapper"> <p>truXTRAC Total Nucleic Acid kits use AFA® technology to actively and concurrently extract both DNA and RNA from formalin-fixed, paraffin-embedded (FFPE) tissue in an aqueous buffer. This dual extraction workflow has been designed to maximize recovery of intact nucleic acids, allowing researchers to detect low frequency mutations and rare gene fusion events.</p> <p> </p> <p><a class="image-popup-no-margins" href="https://www.covaris.com/wp/wp-content/uploads/2020/06/FFPE_workflow-1024x277.jpg"><img class="alignnone wp-image-27662 size-large" src="https://www.covaris.com/wp/wp-content/uploads/2020/06/FFPE_workflow-1024x277.jpg" alt="High-throughput FFPE tissue extraction workflow powered by Covaris AFA technology for NGS-quality DNA and RNA" width="1024" height="277" /></a></p> <p>Learn more in our <a href="https://www.covaris.com/wp/wp-content/uploads/resources_pdf/M020079.pdf" target="_blank" rel="noopener noreferrer">truXTRAC FFPE total nucleic acid flyer</a>.</p> </div> </div> </div></div></div></div><div id="rna_results" class="vc_row wpb_row vc_inner vc_row-fluid vc_custom_1583760619014"><div class="wpb_column vc_column_container vc_col-sm-12"><div class="vc_column-inner"><div class="wpb_wrapper"><h2 style="color: #2d3e51;text-align: left" class="vc_custom_heading vc_do_custom_heading vc_custom_1586371693757" >High-Quality RNA Results</h2> <div class="wpb_text_column wpb_content_element vc_custom_1714648068618 custom_h5" > <div class="wpb_wrapper"> <p>FFPE RNA quality from precious clinical samples have the potential of impacting all downstream analytical applications. FFPE RNA extraction with Covaris is superior for scrolls, cores, and low mass inputs from slides. The improved extraction workflow leads to longer RNA yields with high DV200 scores allowing you to detect rare fusion events and lower your QNS rate.</p> <p><a class="image-popup-no-margins" href="https://www.covaris.com/wp/wp-content/uploads/2020/03/LowerQNSRates.jpg"><br /> <img src="https://www.covaris.com/wp/wp-content/uploads/2020/03/LowerQNSRates.jpg" /><br /> </a></p> <p>Results are derived from an optimized protocol that is available solely as a service through Discovery Life Sciences' sequencing and bioinformatics laboratory - HudsonAlpha Discovery. (Levy, S. The ORIEN Project- Large Scale Integration of FFPE Material into a Multisite Research Alliance. Oral presentation at AACR 2019; April 1, 2019).</p> <p> </p> <p>Learn more about the benefits of FFPE RNA extraction with Covaris in the <a href="https://covaris.com/wp/wp-content/uploads/M020127.pdf" target="_blank" rel="noopener noreferrer">FFPE RNA Quality Application Note</a>.</p> </div> </div> </div></div></div></div><div id="fragment" class="vc_row wpb_row vc_inner vc_row-fluid"><div class="wpb_column vc_column_container vc_col-sm-12"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_video_widget wpb_content_element vc_clearfix vc_custom_1583913707037 vc_video-aspect-ratio-169 vc_video-el-width-100 vc_video-align-left" > <div class="wpb_wrapper"> <div class="wpb_video_wrapper"><iframe title="Improve FFPE Extractions from cores with Covaris" width="500" height="281" src="https://www.youtube.com/embed/eHz-WdpD4P8?feature=oembed" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" referrerpolicy="strict-origin-when-cross-origin" allowfullscreen></iframe></div> </div> </div> <div class="wpb_text_column wpb_content_element vc_custom_1714648078857 custom_h5" > <div class="wpb_wrapper"> <p>An excerpt from the presentation: The ORIEN Project- Large Scale Integration of FFPE Material into a Multisite Research Alliance</p> <p>Presented by Shawn Levy, PhD, Faculty Investigator, Discovery Life Sciences</p> <p>Interested in learning more about Discovery Life Sciences’ workflow with Covaris truXTRAC FFPE technology? Watch the <a href="https://www.youtube.com/watch?v=TaQTovYyhoI">full video.</a></p> </div> </div> </div></div></div></div><div id="diagnostic_decisions" class="vc_row wpb_row vc_inner vc_row-fluid vc_custom_1583920431735"><div class="wpb_column vc_column_container vc_col-sm-12"><div class="vc_column-inner"><div class="wpb_wrapper"><h2 style="color: #2d3e51;text-align: left" class="vc_custom_heading vc_do_custom_heading vc_custom_1583920183565" >Empowering improved diagnostic decisions through an automated clinical FFPE extraction workflow</h2> <div class="wpb_text_column wpb_content_element vc_custom_1714648086634 custom_h5" > <div class="wpb_wrapper"> <p>Formalin-fixed, paraffin-embedded (FFPE) methods are the preferred way to archive clinical tissue biopsy samples for histopathological diagnosis. As advances in clinical molecular pathology continue, there is an increasing need for reliable FFPE extraction methods from FFPE tissue specimens. However, nucleic acid extraction from FFPE samples can be challenging and labor intensive, often resulting in degraded and fragmented DNA.</p> <p>OmniSeq® was founded to advance personalized medicine through their offering of New York State CLEP approved comprehensive molecular profiling, as well as offer a wide variety of pharmaceutical services to assist in drug development. OmniSeq utilizes Covaris AFA-energetics platform technology and truXTRAC® FFPE kits in their extraction workflows for higher extraction yields and quality DNA and RNA from FFPE samples, allowing physicians and clinicians to receive actionable results, and their patients to receive a more accurate diagnosis.</p> </div> </div> <div class="wpb_video_widget wpb_content_element vc_clearfix vc_custom_1583913891485 vc_video-aspect-ratio-169 vc_video-el-width-100 vc_video-align-left" > <div class="wpb_wrapper"> <div class="wpb_video_wrapper"><iframe title="A Novel Solution to FFPE Extraction Challenges for Downstream Clinical Assays" width="500" height="281" src="https://www.youtube.com/embed/Zbw49I18VWQ?feature=oembed" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" referrerpolicy="strict-origin-when-cross-origin" allowfullscreen></iframe></div> </div> </div> <div class="wpb_text_column wpb_content_element vc_custom_1714648096221 custom_h5" > <div class="wpb_wrapper"> <p>A Novel Solution to FFPE Extraction Challenges for Downstream Clinical Assays</p> <p>Presented by: Sean Glenn, PhD, Vice President Clinical and Research Development, OmniSeq</p> <p>The efficiency and reproducibility of their co-extraction workflow enabled OmniSeq to increase throughput to a point where automation was required. Covaris and Dynamic Devices collaborated to successfully design and build a custom automated extraction platform using the integration compatible Covaris LE220R-plus Focused-Ultrasonicator and Dynamic Devices Lynx LM1200 Liquid Handler. The result was a standardized clinical FFPE extraction workflow providing higher confidence in their downstream results with higher yields and corresponding higher DV200 scores, increased efficiency, decreased sample variability and reduction on manual “touchpoints” throughout the process. <a href="/automation/">Click here</a> to learn more about Covaris automated sample preparation capabilities.</p> </div> </div> </div></div></div></div><div class="vc_row wpb_row vc_inner vc_row-fluid instrument_lev_1_quote vc_custom_1583919805090"><div class="wpb_column vc_column_container vc_col-sm-12"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element" > <div class="wpb_wrapper"> <p><img class="aligncenter" src="/wp/wp-content/uploads/2020/02/quote.png"" /></p> </div> </div> <div style="color: #2c2c2c;text-align: center" class="vc_custom_heading vc_do_custom_heading h5" ><em>“In collaboration with Covaris and Omniseq, we automated Omniseq's clinical FFPE DNA and RNA co-extraction workflow, improving their scalability and throughput. The combination of Covaris' AFA technology for extraction and Dynamic Devices Lynx's ST96 Pipettor with iPAW gripper arm produced complex movements and robust pipetting for dealing with difficult or variable sample types. This all enabled the workflow to be reproducible and accurate for the required diagnostic tests.”</em></div><div style="color: #2d3e51;text-align: center" class="vc_custom_heading vc_do_custom_heading h6" ><em>Jeff Kent</em></div><p style="color: #2d3e51;text-align: center" class="vc_custom_heading vc_do_custom_heading vc_custom_1714647568550" ><em>Dynamic Devices</em></p></div></div></div></div><div id="ffpe_tissue_extraction" class="vc_row wpb_row vc_inner vc_row-fluid vc_custom_1586371914185"><div class="wpb_column vc_column_container vc_col-sm-12"><div class="vc_column-inner"><div class="wpb_wrapper"><h2 style="color: #2d3e51;text-align: left" class="vc_custom_heading vc_do_custom_heading vc_custom_1593006303726" >Protein Extraction from FFPE Tissue</h2> <div class="wpb_text_column wpb_content_element vc_custom_1714648108278 custom_h5" > <div class="wpb_wrapper"> <p>A simple, efficient, and optimized<a href="https://www.covaris.com/wp/wp-content/uploads/2020/04/HUPO-2018-ProtiFi-Covaris-Poster.pdf"> proteomics workflow</a> is also enabled by Covaris AFA technology. The protocol developed for protein extraction from FFPE material drastically improves sample preparation by actively removing more paraffin while rehydrating tissue to isolate proteins prior to purification.</p> </div> </div> </div></div></div></div><div id="mobile_padding_top" class="vc_row wpb_row vc_inner vc_row-fluid vc_custom_1586372672893"><div class="wpb_column vc_column_container vc_col-sm-12"><div class="vc_column-inner"><div class="wpb_wrapper"><h2 style="color: #2d3e51;text-align: left" class="vc_custom_heading vc_do_custom_heading vc_custom_1583920655761" >Covaris AFA Paired with S-Trap Columns</h2> <div class="wpb_text_column wpb_content_element vc_custom_1729773749836 instrument_bullet_list" > <div class="wpb_wrapper"> <ul class="sidebar_list"> <li>Up to 97% protein recovery using S-Trap Column</li> <li>Easy-to-use, simple, and efficient workflow</li> <li>Rapidly process up to 96 samples in less than 5 hours</li> <li>Highly improved active paraffin removal</li> <li>Improved protein solubilization enabled by AFA and 5% SDS</li> <li>No need for toxic organic solvents, such as xylene</li> </ul> <h5 style="text-align: center;">FFPE Protein Extraction Workflow with S-Trap</h5> <p><a class="image-popup-no-margins" href="https://www.covaris.com/wp/wp-content/uploads/2020/03/ProtiFiWorkflow.jpg"><br /> <img class="alignnone" src="https://www.covaris.com/wp/wp-content/uploads/2020/03/ProtiFiWorkflow.jpg" alt="FFPE Protein Extraction Workflow with S-Trap" width="700" height="458" /><br /> </a></p> </div> </div> </div></div></div></div></div></div></div></div><div id="featured_product" class="vc_row wpb_row vc_row-fluid cmspage_menu vc_custom_1586372053002"><div class="wpb_column vc_column_container vc_col-sm-3"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div><div class="wpb_column vc_column_container vc_col-sm-9"><div class="vc_column-inner"><div class="wpb_wrapper"><div style="color: #2d3e51;text-align: left" class="vc_custom_heading vc_do_custom_heading h2 vc_custom_1714648147512" >Featured Products</div><div class="vc_row wpb_row vc_inner vc_row-fluid instrument_lev_1 vc_custom_1583494563486 vc_row-o-equal-height vc_row-flex"><div class="wpb_column vc_column_container vc_col-sm-4"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element vc_custom_1583759693959" > <div class="wpb_wrapper"> <p><img class="alignnone size-full wp-image-15282" src="https://www.covaris.com/wp/wp-content/uploads/2020/02/truXTRAC_FFPE_DNA.jpg" alt="" width="200" height="103" /></p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-8"><div class="vc_column-inner"><div class="wpb_wrapper"><div style="color: #2d3e51;text-align: left" class="vc_custom_heading vc_do_custom_heading h4 vc_custom_1714647744528" >truXTRAC FFPE total NA Kit - Magnetic Bead</div><div style="color: #020202;text-align: left" class="vc_custom_heading vc_do_custom_heading h6" >Reagents and consumables required for the sequential extraction and purification of DNA and RNA from 25 FFPE tissue samples.</div><div class="vc_btn3-container vc_btn3-inline vc_custom_1677012876476 vc_do_btn" ><a style="background-color:#ededed; color:#015cb8;" class="vc_general vc_btn3 vc_btn3-size-md vc_btn3-shape-rounded vc_btn3-style-custom vc_btn3-icon-right" href="https://www.covaris.com/truxtrac-ffpe-total-na-kit-magnetic-bead" title="">READ MORE <i class="vc_btn3-icon fas fa-arrow-left"></i></a></div></div></div></div></div><div class="vc_row wpb_row vc_inner vc_row-fluid instrument_lev_1 vc_custom_1583494563486 vc_row-o-equal-height vc_row-flex"><div class="wpb_column vc_column_container vc_col-sm-4"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element vc_custom_1583759693959" > <div class="wpb_wrapper"> <p><img class="alignnone size-full wp-image-15282" src="https://www.covaris.com/wp/wp-content/uploads/2020/02/truXTRAC_FFPE_DNA.jpg" alt="" width="200" height="103" /></p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-8"><div class="vc_column-inner"><div class="wpb_wrapper"><div style="color: #2d3e51;text-align: left" class="vc_custom_heading vc_do_custom_heading h4 vc_custom_1714647736037" >truXTRAC FFPE RNA Plus Kit - Magnetic Bead</div><div style="color: #020202;text-align: left" class="vc_custom_heading vc_do_custom_heading h6" >Reagents and consumables required for the extraction and purification of RNA from 24 FFPE tissue samples.</div><div class="vc_btn3-container vc_btn3-inline vc_custom_1677012995866 vc_do_btn" ><a style="background-color:#ededed; color:#015cb8;" class="vc_general vc_btn3 vc_btn3-size-md vc_btn3-shape-rounded vc_btn3-style-custom vc_btn3-icon-right" href="https://www.covaris.com/truxtrac-ffpe-rna-plus-kit-magnetic-bead" title="">READ MORE <i class="vc_btn3-icon fas fa-arrow-left"></i></a></div></div></div></div></div><div class="vc_row wpb_row vc_inner vc_row-fluid instrument_lev_1 vc_custom_1583494563486 vc_row-o-equal-height vc_row-flex"><div class="wpb_column vc_column_container vc_col-sm-4"><div class="vc_column-inner"><div class="wpb_wrapper"> <div class="wpb_text_column wpb_content_element vc_custom_1583759693959" > <div class="wpb_wrapper"> <p><img class="alignnone size-full wp-image-15282" src="https://www.covaris.com/wp/wp-content/uploads/2020/02/truXTRAC_FFPE_DNA.jpg" alt="" width="200" height="103" /></p> </div> </div> </div></div></div><div class="wpb_column vc_column_container vc_col-sm-8"><div class="vc_column-inner"><div class="wpb_wrapper"><div style="color: #2d3e51;text-align: left" class="vc_custom_heading vc_do_custom_heading h4 vc_custom_1714647752515" >truXTRAC FFPE total NA Ultra Kit – Magnetic Beads</div><div style="color: #020202;text-align: left" class="vc_custom_heading vc_do_custom_heading h6" >Reagents and consumables required for extraction and purification of DNA and RNA from 25 FFPE tissue samples using the new AFA-TUBE PP Screw-Cap 0.5 ml</div><div class="vc_btn3-container vc_btn3-inline vc_custom_1677013160962 vc_do_btn" ><a style="background-color:#ededed; color:#015cb8;" class="vc_general vc_btn3 vc_btn3-size-md vc_btn3-shape-rounded vc_btn3-style-custom vc_btn3-icon-right" href="https://www.covaris.com/truxtrac-ffpe-total-na-ultra-kit-magnetic-beads" title="">READ MORE <i class="vc_btn3-icon fas fa-arrow-left"></i></a></div></div></div></div></div></div></div></div></div><div id="resources" class="vc_row wpb_row vc_row-fluid cmspage_menu category_resources vc_custom_1586372095324"><div class="wpb_column vc_column_container vc_col-sm-3"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div><div class="wpb_column vc_column_container vc_col-sm-9"><div class="vc_column-inner vc_custom_1583492989135"><div class="wpb_wrapper"><h2 style="color: #2d3e51;text-align: left" class="vc_custom_heading vc_do_custom_heading vc_custom_1579697651435" >Resources</h2><div class="vc_row wpb_row vc_inner vc_row-fluid vc_custom_1583492996693 vc_row-o-equal-height vc_row-flex"><div class="sidebar_resources wpb_column vc_column_container vc_col-sm-6"><div class="vc_column-inner"><div class="wpb_wrapper"><div style="color: #2d3e51;text-align: left" class="vc_custom_heading vc_do_custom_heading h5 vc_custom_1714647625846" >FFPE Extraction Protocols</div><div style="color: #020202;text-align: left" class="vc_custom_heading vc_do_custom_heading h6 vc_custom_1714648629941" >Protocols for using truXTRAC FFPE Kits with Covaris Adaptive Focused Acoustics (AFA) technology.</div><div class="vc_btn3-container vc_btn3-inline vc_custom_1587936519706 vc_do_btn" ><a style="background-color:#ffffff; color:#015cb8;" class="vc_general vc_btn3 vc_btn3-size-md vc_btn3-shape-rounded vc_btn3-style-custom" href="/protocols?filter_tag=Nucleic%20Acid%20Extraction%20from%20FFPE%20Protocols" title="">LEARN MORE</a></div></div></div></div><div class="sidebar_resources wpb_column vc_column_container vc_col-sm-6"><div class="vc_column-inner"><div class="wpb_wrapper"><div style="color: #2d3e51;text-align: left" class="vc_custom_heading vc_do_custom_heading h5 vc_custom_1714647639657" >FFPE Extraction Application Notes</div><div style="color: #020202;text-align: left" class="vc_custom_heading vc_do_custom_heading h6 vc_custom_1717097450992" >App notes to support FFPE extraction workflows powered by Covaris Adaptive Focused Acoustics (AFA) technology.</div><div class="vc_btn3-container vc_btn3-inline vc_custom_1587936536988 vc_do_btn" ><a style="background-color:#ffffff; color:#015cb8;" class="vc_general vc_btn3 vc_btn3-size-md vc_btn3-shape-rounded vc_btn3-style-custom" href="/application-technical-notes?filter_tag=Extraction%20from%20FFPE%20Samples" title="">LEARN MORE</a></div></div></div></div></div><div class="vc_row wpb_row vc_inner vc_row-fluid vc_custom_1583492996693 vc_row-o-equal-height vc_row-flex"><div class="sidebar_resources wpb_column vc_column_container vc_col-sm-6"><div class="vc_column-inner"><div class="wpb_wrapper"><div style="color: #2d3e51;text-align: left" class="vc_custom_heading vc_do_custom_heading h5 vc_custom_1714647611768" >FFPE Extraction Videos</div><div style="color: #020202;text-align: left" class="vc_custom_heading vc_do_custom_heading h6 vc_custom_1714648642734" >Webinars, customer driven presentations and technology videos highlighting FFPE extraction capabilities with Covaris Adaptive Focused Acoustics (AFA) technology.</div><div class="vc_btn3-container vc_btn3-inline vc_custom_1587936576600 vc_do_btn" ><a style="background-color:#ffffff; color:#015cb8;" class="vc_general vc_btn3 vc_btn3-size-md vc_btn3-shape-rounded vc_btn3-style-custom" href="/videos?filter_tag=FFPE%20Extraction" title="">LEARN MORE</a></div></div></div></div></div></div></div></div></div><div id="references" class="vc_row wpb_row vc_row-fluid cmspage_menu category_resources vc_custom_1587365319655"><div class="wpb_column vc_column_container vc_col-sm-3"><div class="vc_column-inner"><div class="wpb_wrapper"></div></div></div><div class="wpb_column vc_column_container vc_col-sm-9"><div class="vc_column-inner vc_custom_1583492989135"><div class="wpb_wrapper"><div style="color: #2d3e51;text-align: left" class="vc_custom_heading vc_do_custom_heading h2 vc_custom_1714647600576" >References</div> <div class="wpb_text_column wpb_content_element" > <div class="wpb_wrapper"> <ol> <li>V Pestinger, et al. - 2020 <a href="https://www.medrxiv.org/content/10.1101/2020.02.01.20019992v1">Use of an integrated pan-cancer oncology enrichment NGS assay to measure tumour mutational burden and detect clinically actionable variants</a></li> <li>Robbe, et al.- 2018 <a href="https://www.nature.com/articles/gim2017241" target="_blank" rel="noopener noreferrer">Clinical whole-genome sequencing from routine formalin-fixed, paraffin-embedded specimens: pilot study for the 100,000 Genomes Project</a></li> <li>Calsina B, et al. - 2018 <a href="https://www.ncbi.nlm.nih.gov/pubmed/?term=Role+of+MDH2+pathogenic+variant+in+pheochromocytoma+and+paraganglioma+patients" target="_blank" rel="noopener noreferrer">Role of MDH2 pathogenic variant in pheochromocytoma and paraganglioma patients.</a></li> <li>Edmund CP Chedgy, et al. - 2018 <a href="https://onlinelibrary.wiley.com/doi/pdf/10.1002/path.5137" target="_blank" rel="noopener noreferrer">Biallelic Tumor Suppressor Loss and DNA Repair Defects in de novo Small Cell Prostate Cancer</a></li> <li>Stine H. Kresse, et al. - 2018 <a href="http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197456" target="_blank" rel="noopener noreferrer">Evaluation of Commercial DNA and RNA Extraction Methods for High-Throughput Sequencing of FFPE Samples</a></li> <li>Carsten Holzmann, et al. - 2018 <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021249/" target="_blank" rel="noopener noreferrer">Malignant Transformation of Uterine Leiomyoma to Myxoid Leiomyosarcoma After Morcellation Associated with ALK Rearrangement and Loss of 14q</a></li> <li>Catherine Zilberg, et al. - 2018 <a href="https://www.nature.com/articles/modpathol2017128" target="_blank" rel="noopener noreferrer">Analysis of Clinically Relevant Somatic Mutations in High-Risk Head and Neck Cutaneous Squamous Cell Carcinoma</a></li> <li>Jeffrey M. Conroy, et al. - The Journal of Molecular Diagnostics, 2018 <a href="https://www.sciencedirect.com/science/article/pii/S152515781730363X" target="_blank" rel="noopener noreferrer">Analytical Validation of a Next-Generation Sequencing Assay to Monitor Immune Responses in Solid Tumors</a></li> <li>Katrin Bankov, et al. - Clinical and Translational Gastroenterology, 2018 <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928069/" target="_blank" rel="noopener noreferrer">Sequencing of Intraductal Biopsies is Feasible and Potentially Impacts Clinical Management of Patients with Indeterminate Biliary Stricture and Cholangiocarcinoma</a></li> <li>Brannan B. Griffin, et al. - International Journal of Surgical Pathology, 2017<a href="http://journals.sagepub.com/doi/abs/10.1177/1066896917734915" target="_blank" rel="noopener noreferrer"> Malignant Ectomesenchymoma: Series Analysis of a Histologically and Genetically Heterogeneous Tumor</a></li> </ol> </div> </div> </div></div></div></div> </div> </div> </div> </div> </address></address> <style> .mp-redirect-yes.mpstoreswitcher-select a { color: #757575; text-decoration: none; } .mp-redirect-yes.mpstoreswitcher-select a:hover { color: #FFFFFF; } @media screen and (max-width: 768px) { .mp-redirect-yes.mpstoreswitcher-select { margin-top: 5px; } } </style> </div></div></main><div class="page-bottom"><div class="content"><div class="widget block block-static-block"> <p><script> (function(d,b,a,s,e){ var t = b.createElement(a), fs = b.getElementsByTagName(a)[0]; t.async=1; t.id=e; t.src=s; fs.parentNode.insertBefore(t, fs); }) (window,document,'script','https://tag.demandbase.com/4f14a8c59acde313.min.js','demandbase_js_lib'); </script> <script type="text/javascript"> piAId = '420802'; piCId = '161336'; piHostname = 'pi.pardot.com'; (function() { function async_load(){ var s = document.createElement('script'); s.type = 'text/javascript'; s.src = ('https:' == document.location.protocol ? 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