Recombinant Human GM-CSF GMP Protein, CF (215-GMP) by R&D Systems, Part of Bio-Techne

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class="col sub-menu-wrapper"> <div class="sub-menu-header"> Product & Instrument Tools<span class="icon-keyboard_arrow_down submenu-caret"></span> <hr/> <div class="menu-children-wrap sub-menu-box"> <a href="/resources/cofa-finder-tool" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/cofa-finder-tool">Certificate of Analysis (COA) Finder Tool</a> <a href="/resources/calculators" class="dropdown-item text-wrap" data-drupal-link-system-path="node/7416">Calculators</a> <a href="/resources/flow-cytometry-panel-builder" class="dropdown-item text-wrap" data-drupal-link-system-path="node/8821">Flow Cytometry Panel Builder</a> <a href="/luminex-assay-customization-tool" class="dropdown-item text-wrap" data-drupal-link-system-path="luminex-assay-customization-tool">Luminex Assay Customization Tool</a> <a href="/resources/product-insert-lookup-tool" class="dropdown-item text-wrap" data-drupal-link-system-path="resources/product-insert-lookup-tool">Product Insert Lookup 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Datasheet / COA / SDS</a> </article> </div> </div> </div> </div> </div> <div id="new_version_available"> </div> <div class="row mb-2" id="extended-description"> <div class="col-md-10 extended-description-wrapper" id="extended-description-wrapper"> Animal-Free. </div> </div> </div> <div class="col-lg-3 col-md-12"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-rnd-systems.svg" alt="R&D Systems, part of Bio-Techne" class="d-flex h-100 w-100"> </div> </div> </div> <div class="row border-top mb-2" id="images-orderdetail-wrapper"> <div class="col-xl-6 mt-2" id="images-wrapper" data-section="image_summary"> <div id="image-tree" data-section="component-product-image-tree" class="vertical lightbox" data-mdb-zoom-effect="true"> <div id="product-image-gallery" class="row"> <div class="col-md-2 d-none d-md-block"> <ul class="list-inline m-0"> <li data-id="1" class="product-image-lightbox border rounded mb-2 list-inline-item"> <div class="text-center mt-1"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/protein/GM-CSF_215-GMP_16.jpg" data-srcset="https://resources.bio-techne.com/images/products/protein/GM-CSF_215-GMP_16.jpg" alt="Recombinant Human GM-CSF GMP Protein SDS-PAGE" title="Recombinant Human GM-CSF GMP Protein SDS-PAGE" data-caption="1 μg/lane of GMP-grade Recombinant Human GM-CSF (Catalog # 215-GMP) was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 14 kDa." data-badges='' data-mdb-img="https://resources.bio-techne.com/images/products/protein/GM-CSF_215-GMP_16.jpg" data-id="0" data-application="https://resources.bio-techne.com/images/products/protein/GM-CSF_215-GMP_16.jpg" class="lazy" /> </div> </li> <li data-id="2" class="product-image-lightbox border rounded mb-2 list-inline-item"> <div class="text-center mt-1"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/protein/GM-CSF_215-GMP_23.jpg" data-srcset="https://resources.bio-techne.com/images/products/protein/GM-CSF_215-GMP_23.jpg" alt="Recombinant Human GM-CSF GMP Protein Mass Spectrometry" title="Recombinant Human GM-CSF GMP Protein Mass Spectrometry" data-caption="MALDI-TOF analysis of GMP-grade Recombinant Human GM-CSF (Catalog # 215-GMP). The major peak corresponds to the calculated molecular mass, 14478 Da. The minor peak at 14673 Da is a matrix-associated artifact of the MALDI-TOF." data-badges='' data-mdb-img="https://resources.bio-techne.com/images/products/protein/GM-CSF_215-GMP_23.jpg" data-id="1" data-application="https://resources.bio-techne.com/images/products/protein/GM-CSF_215-GMP_23.jpg" class="lazy" /> </div> </li> </ul> </div> <div class="col-md-10 border rounded d-flex align-items-center justify-content-center product-image-lightbox"> <div class="text-center my-2" data-brand="rnd"> <img src="https://resources.bio-techne.com/images/products/protein/GM-CSF_215-GMP_14.jpg" alt="Recombinant Human GM-CSF GMP Protein Bioactivity" title="Recombinant Human GM-CSF GMP Protein Bioactivity" data-caption="GMP-grade Recombinant Human GM-CSF (Catalog # 215-GMP) stimulates pro-liferation of TF‑1 human erythroleukemic cell line. The ED<sub>50</sub> is 6-30 pg/mL." data-badges='' data-id="0" width="250" height="250" fetchpriority="high" as="image" class="search_result_thumbnail_image active" /> </div> </div> </div> </div> </div> <div class="col-xl-6 mt-2" id="orderdetails-wrapper" data-section="order_detail_block"> <div class="atc-container"> <div class="atc-block" data-type="ds" data-blockid="ProductCart" > <form action="/commerce/addtocart" method="post" class="add-to-cart-block" data-productcode="215-GMP"> <input type="hidden" name="print-quote" class="print-quote-input" value=""> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-4 col-md-3 font-weight-bold p-0">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-4 p-0 font-weight-bold d-none d-md-block">Availability</div> <div class="commerce-atc-price atc-head col-4 col-md-3 p-0 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head 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class="icon-icon-check-circle"></span> <a href="/guarantee">100% Guarantee</a> </div> </div> </div> </div> </div> <div id="tabs-distributor" class="row"> <div class="tab-content col-xl-9 mt-2"> <div data-section="section-base--nav-tabs-content"> <ul class="nav nav-tabs nav-fill" id="productTab" role="tablist"> <li class="nav-item" role="presentation"> <a class="nav-link tab-anchor active" href="#tab-technical_data" id="technical_data-tab" data-toggle="tab" data-target="#technical_data" type="button" role="tab" aria-controls="technical_data" aria-selected="true"> <p class="m-0">Technical Data</p> </a> </li> <li class="nav-item" role="presentation"> <a class="nav-link tab-anchor " href="#tab-citations_reviews" id="citations_reviews-tab" data-toggle="tab" data-target="#citations_reviews" type="button" role="tab" aria-controls="citations_reviews" aria-selected="false"> <p class="m-0">Citations & Reviews</p> </a> </li> <li class="nav-item" role="presentation"> <a class="nav-link tab-anchor 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Background</a> </li> <li class="nav-item m-0"> <a class="nav-link d-inline jump-anchor " href="#product-documents"> Product Documents</a> </li> <li class="nav-item m-0"> <a class="nav-link d-inline jump-anchor " href="#manufacturing-specifications"> Manufacturing Specifications</a> </li> <li class="nav-item m-0"> <a class="nav-link d-inline jump-anchor " href="#specific-notices"> Specific Notices</a> </li> </ul> </div> <div id="key_details" class="py-5 bt-pp-border-bottom" data-section="section-base--key-details"> <h3>Key Product Details</h3> <div class="mt-4 py-2 container"> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Source</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> E. coli </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Accession #</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> <a href="https://www.ncbi.nlm.nih.gov/protein/P04141.1" class="a___link-external" target="_blank" rel="nofollow">P04141.1</a> </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Conjugate</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Unconjugated </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Applications</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Bioactivity </div> </div> </div> <div class="container"> <div class="row product-data"> <div class="col-lg-6 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4><a href="/t/gm-csf/proteins-enzymes">View all GM-CSF Proteins and Enzymes »</a></h4> </div> </div> </div> </div> <div class="border-top border-bottom recommended-products-section" id="recommendation-viewed" data-product_code="215-GMP" data-type=viewed></div> <div id="product-specifications" class="bt-pp-border-bottom py-5" data-section="section-base--product-specifications"> <h3>Product Specifications</h3> <div class="mt-4 py-2 container"> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Source</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> <em>E. coli</em>-derived human GM-CSF protein<br>Ala18-Glu144<br>Produced using non-animal reagents in an animal-free laboratory. <br>Manufactured and tested under cGMP guidelines. </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Purity</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> >97%, by SDS-PAGE under reducing conditions and visualized by silver stain. </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Endotoxin Level</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> <0.10 EU per 1 μg of the protein by the LAL method. </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>N-terminal Sequence Analysis</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Ala-Pro-Ala-Arg-Ser-Pro-Ser-Pro-Ser-Thr </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Predicted Molecular Mass</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> 14.5 kDa </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>SDS-PAGE</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> 14 kDa, reducing conditions </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Activity</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. Kitamura, T. <EM>et al</EM>. (1989) J. Cell Physiol. <STRONG>140</STRONG>:323.<br />The ED<sub>50</sub> for this effect is 6-30 pg/mL.<br>The specific activity of recombinant human GM-CSF is >1.0 x 10<sup>7</sup> IU/mg, which is calibrated against the human GM-CSF WHO International Standard (NIBSC code: 88/646). </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Host Cell Protein</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> < 0.5 ng per µg of protein when tested by ELISA. </div> </div> <div class="row product-data"> <div class="col-lg-3 font-weight-bold product-data-label py-2 align-top text-bt-dark-blue"> <h4>Mycoplasma</h4> </div> <div class="col-lg-9 product-data-value py-2 align-top text-break"> Negative for Mycoplasma. </div> </div> </div> <h4 class="mt-3">Reviewed Applications</h4> <p><span class="review_stars review_stars_5"></span> Read <a href="#reviews" class="reviews">1 review</a> rated 5 using 215-GMP in the following applications:</p> <ul class="list-unstyled"> <li><a href="#reviews" class="reviews" data-application="Stem/Immune cell maintenance or differentiation ">Stem/Immune cell maintenance or differentiation (1 Review) </a></li> </ul> </div> <div id="scientific-data" class="bt-pp-border-bottom py-5" data-anchor-label="Scientific Data" data-section="section-base--scientific-data"> <div> <h3>Scientific Data Images for Recombinant Human GM-CSF GMP Protein, CF </h3> </div> <div class="product-data-wrapper mt-5" id="scientific-data-table" data-scientific-count="0"> <div> <div class="row m___product-data-examples my-4" data-section="product-image-divs"> <div class="col-md-2 border-0 mb-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/protein/GM-CSF_215-GMP_14.jpg" data-srcset="https://resources.bio-techne.com/images/products/protein/GM-CSF_215-GMP_14.jpg" alt="Recombinant Human GM-CSF GMP Protein Bioactivity" title="Recombinant Human GM-CSF GMP Protein Bioactivity" data-caption="GMP-grade Recombinant Human GM-CSF (Catalog # 215-GMP) stimulates pro-liferation of TF‑1 human erythroleukemic cell line. The ED<sub>50</sub> is 6-30 pg/mL." data-badges="" data-application="Bioactivity" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> <div class="col-md-9 border-0 align-top"> <h4 class="font-weight-bold">Recombinant Human GM-CSF GMP Protein Bioactivity</h4> GMP-grade Recombinant Human GM-CSF (Catalog # 215-GMP) stimulates pro-liferation of TF‑1 human erythroleukemic cell line. The ED<sub>50</sub> is 6-30 pg/mL. </div> </div> </div> <div> <div class="row m___product-data-examples my-4" data-section="product-image-divs"> <div class="col-md-2 border-0 mb-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/protein/GM-CSF_215-GMP_16.jpg" data-srcset="https://resources.bio-techne.com/images/products/protein/GM-CSF_215-GMP_16.jpg" alt="Recombinant Human GM-CSF GMP Protein SDS-PAGE" title="Recombinant Human GM-CSF GMP Protein SDS-PAGE" data-caption="1 μg/lane of GMP-grade Recombinant Human GM-CSF (Catalog # 215-GMP) was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 14 kDa." data-badges="" data-application="SDS-Page" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> <div class="col-md-9 border-0 align-top"> <h4 class="font-weight-bold">Recombinant Human GM-CSF GMP Protein SDS-PAGE</h4> 1 μg/lane of GMP-grade Recombinant Human GM-CSF (Catalog # 215-GMP) was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 14 kDa. </div> </div> </div> <div> <div class="row m___product-data-examples my-4" data-section="product-image-divs"> <div class="col-md-2 border-0 mb-3"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand="rnd"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/protein/GM-CSF_215-GMP_23.jpg" data-srcset="https://resources.bio-techne.com/images/products/protein/GM-CSF_215-GMP_23.jpg" alt="Recombinant Human GM-CSF GMP Protein Mass Spectrometry" title="Recombinant Human GM-CSF GMP Protein Mass Spectrometry" data-caption="MALDI-TOF analysis of GMP-grade Recombinant Human GM-CSF (Catalog # 215-GMP). The major peak corresponds to the calculated molecular mass, 14478 Da. The minor peak at 14673 Da is a matrix-associated artifact of the MALDI-TOF." data-badges="" data-application="Mass Spectrometry" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </div> <div class="col-md-9 border-0 align-top"> <h4 class="font-weight-bold">Recombinant Human GM-CSF GMP Protein Mass Spectrometry</h4> MALDI-TOF analysis of GMP-grade Recombinant Human GM-CSF (Catalog # 215-GMP). The major peak corresponds to the calculated molecular mass, 14478 Da. The minor peak at 14673 Da is a matrix-associated artifact of the MALDI-TOF. </div> </div> </div> <span class="product-data-wrapper table" id="more-scientific-data" style="display:none"> </span> </div> </div> <div id="preparation--storage" class="bt-pp-border-bottom py-5" data-section="section-protein--preparation-storage"> <h3>Formulation, Preparation and Storage</h3> <div class="datasheet_section"> <div class="row px-3"> <div class="col-xs-12 "> <div class="border-left border-right border-top text-center"> <h5 class="m-0 p-3 bg-dark-bt-blue text-white"> 215-GMP </h5> </div> <table class="ds_table_html table-bordered tablesaw tablesaw-stack"> <tbody> <tr> <td class="font-weight-bold">Formulation</td> <td class="w-75">Lyophilized from a 0.2 μm filtered solution in PBS.</td> </tr> <tr> <td class="font-weight-bold">Reconstitution</td> <td class="w-75">Reconstitute at 100-200 μg/mL in PBS.</td> </tr> <tr> <td class="font-weight-bold">Shipping</td> <td class="w-75">The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.</td> </tr> <tr> <td class="font-weight-bold">Stability & Storage</td> <td class="w-75"><b>Use a manual defrost freezer and avoid repeated freeze-thaw cycles. </b><UL><LI>A minimum of 12 months when stored at ≤ -20 °C as supplied. Refer to lot specific COA for the Use by Date. </LI><LI>1 month, 2 to 8 °C under sterile conditions after reconstitution.</LI><LI>3 months, ≤ -20 °C under sterile conditions after reconstitution.</LI></UL></td> </tr> </tbody> </table> </div> </div> </div> </div> <div id="background" class="py-5 bt-pp-border-bottom" data-section="section-base--background-info"> <h3>Background: GM-CSF</h3> <article class="product-data-wrapper"> GM‑CSF was initially characterized as a factor that can support the <em>in vitro </em>colony formation of granulocyte‑macrophage progenitors. It is also a growth factor for erythroid, megakaryocyte, and eosinophil progenitors. GM‑CSF is produced by a number of different cell types (including T cells, B cells, macrophages, mast cells, endothelial cells, fibroblasts, and adipocytes) in response to cytokine or inflammatory stimuli. On mature hematopoietic cells, GM‑CSF is a survival factor for and activates the effector functions of granulocytes, monocytes/macrophages, and eosinophils (1, 2). GM‑CSF promotes a Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity (3‑5). It shows clinical effectiveness in ameliorating chemotherapy‑induced neutropenia, and GM‑CSF transfected tumor cells are utilized as cancer vaccines (6, 7). The 22 kDa glycosylated GM‑CSF, similar to IL‑3 and IL‑5, is a cytokine with a core of four bundled<br> alpha-helices (8‑12). Mature human GM‑CSF shares 63%‑70% amino acid sequence identity with canine, feline, porcine, and rat GM‑CSF and 54% with mouse GM‑CSF. GM‑CSF exerts its biological effects through a heterodimeric receptor complex composed of GM‑CSF R alpha/CD116 and the signal transducing common beta chain (CD131) which is also a component of the high‑affinity receptors for IL‑3 and IL‑5 (13, 14). In addition, GM‑CSF binds a naturally occurring soluble form of GM‑CSF R alpha (15). Human GM‑CSF is active on canine and feline cells but not on murine cells (16‑18). </article> <div id="background_wrapper" class="px-3 mt-2"> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>References</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> <OL> <LI>Martinez-Moczygemba, M. and D.P. Huston (2003) J. Allergy Clin. Immunol. <STRONG>112</STRONG>:653. </LI> <LI>Barreda, D.R. <EM>et al</EM>. (2004) Dev. Comp. Immunol. <STRONG>28</STRONG>:509. </LI> <LI>Eksioglu, E.A. <EM>et al</EM>. (2007) Exp. Hematol. <STRONG>35</STRONG>:1163. </LI> <LI>Cao, Y. (2007) J. Clin. Invest. <STRONG>117</STRONG>:2362. </LI> <LI>Fleetwood, A.J. <EM>et al</EM>. (2005) Crit. Rev. Immunol. <STRONG>25</STRONG>:405.</LI> <LI>Heuser, M. <EM>et al</EM>. (2007) Semin. Hematol. <STRONG>44</STRONG>:148. </LI> <LI>Hege, K.M. <EM>et al</EM>. (2006) Int. Rev. Immunol. <STRONG>25</STRONG>:321. </LI> <LI>Kaushansky, K. <EM>et al</EM>. (1992) Biochemistry <STRONG>31</STRONG>:1881. </LI> <LI>Diederichs, K. <EM>et al</EM>. (1991) Science <STRONG>254</STRONG>:1779.  <LI>Cantrell, M.A. <EM>et al</EM>. (1985) Proc. Natl. Acad. Sci. <STRONG>82</STRONG>:6250. <LI>Lee, F. <EM>et al</EM>. (1985) Proc. Natl. Acad. Sci. <STRONG>82</STRONG>:4360. <LI>Wong, G.G. <EM>et al</EM>. (1985) Science <STRONG>228</STRONG>:810. <LI>Onetto-Pothier, N. <EM>et al</EM>. (1990) Blood <STRONG>75</STRONG>:59. <LI>Hayashida, K. <EM>et al</EM>. (1990) Proc. Natl. Acad. Sci. <STRONG>87</STRONG>:9655. <LI>Pelley, J.L. <EM>et al</EM>. (2007) Exp. Hematol. <STRONG>35</STRONG>:1483. <LI>Hogge, G.S. <EM>et al</EM>. (1990) Cancer Gene Ther. <STRONG>6</STRONG>:26. <LI>Sprague, W.S. <EM>et al</EM>. (2005) J. Comp. Pathol. <STRONG>133</STRONG>:136. <LI>Shanafelt, A.B. <EM>et al</EM>. (1991) J. Biol. Chem. <STRONG>266</STRONG>:13804.</LI></OL> </div> </div> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>Long Name</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> Granulocyte Macrophage Growth Factor </div> </div> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>Alternate Names</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> CSF-2, CSF2, GMCSF, Molgramostim, Sargramostim </div> </div> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>Entrez Gene IDs</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> <a href="https://www.ncbi.nlm.nih.gov/gene?term=1437" class="a___link-external" target="_blank" rel="nofollow">1437</a> (Human); <a href="https://www.ncbi.nlm.nih.gov/gene?term=12981" class="a___link-external" target="_blank" rel="nofollow">12981</a> (Mouse); <a href="https://www.ncbi.nlm.nih.gov/gene?term=116630" class="a___link-external" target="_blank" rel="nofollow">116630</a> (Rat); <a href="https://www.ncbi.nlm.nih.gov/gene?term=397208" class="a___link-external" target="_blank" rel="nofollow">397208</a> (Porcine); <a href="https://www.ncbi.nlm.nih.gov/gene?term=403923" class="a___link-external" target="_blank" rel="nofollow">403923</a> (Canine); <a href="https://www.ncbi.nlm.nih.gov/gene?term=493805" class="a___link-external" target="_blank" rel="nofollow">493805</a> (Feline) </div> </div> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>Gene Symbol</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> CSF2 </div> </div> <div class="row product-data"> <div class=" col-md-3 product-data-label font-weight-bold p-3 align-top border"> <h4>UniProt</h4> </div> <div class=" col-md-9 product-data-value p-3 px-4 text-break border"> <a href="https://www.uniprot.org/uniprot/?query=P04141.1" class="a___link-external" target="_blank" rel="nofollow">P04141.1</a> </div> </div> </div> <h4 class="mt-3">Additional GM-CSF Products</h4> <ul class="list-unstyled"> <li><a href="/t/gm-csf" data-product="GM-CSF">All Products for GM-CSF </a></li> <li><a href="/t/gm-csf/elisa-kits" data-application="GM-CSF ELISA Kits">GM-CSF ELISA Kits </a></li> <li><a href="/t/gm-csf/luminex-assays" data-application="GM-CSF Luminex Assays">GM-CSF Luminex Assays </a></li> <li><a href="/t/gm-csf/lysates" data-application="GM-CSF Lysates">GM-CSF Lysates </a></li> <li><a href="/t/gm-csf/antibodies" data-application="GM-CSF Primary Antibodies">GM-CSF Primary Antibodies </a></li> <li><a href="/t/gm-csf/proteins-enzymes" data-application="GM-CSF Proteins and Enzymes">GM-CSF Proteins and Enzymes </a></li> <li><a href="/t/gm-csf/simple-plex" data-application="GM-CSF Simple Plex">GM-CSF Simple Plex </a></li> </ul> </div> <div id="product-documents" data-section="section-base--product-documents"> <div id="accordion" class="border mb-4"> <div class="rounded-top bg-white"> <h3 class="m-0 p-3"> Product Documents for Recombinant Human GM-CSF GMP Protein, CF </h3> </div> <div class="vtab-section" data-section="Product Datasheets"> <div class="card-header rounded-top"> <a class="" data-toggle="collapse" data-target="#collapse_two" aria-expanded="true" aria-controls="collapse_two" id="product-datasheets-link"> <h5 class="mb-0"> Product Datasheets </h5> </a> </div> <div id="collapse_two" class="collapse show prod_datasheet_link" aria-labelledby="heading_two" data-parent="#accordion"> <div class="card-body"> <div class="row"> <div class="col-md-6"> <a href="https://resources.rndsystems.com/pdfs/datasheets/215-gmp.pdf" class="datasheet_link" target="_blank" rel="nofollow">Download Product Datasheets</a> </div> </div> </div> </div> </div> <div class="card-header"> <a data-toggle="collapse" data-target="#collapse_one" aria-expanded="false" class="collapsed" aria-controls="collapse_one"> <h5 class="mb-0"> COA </h5> </a> </div> <div id="collapse_one" class="collapse " aria-labelledby="heading_one" data-parent="#accordion"> <div class="card-body"> <form novalidate="novalidate" data-drupal-selector="product-coa-form" action="#coa-form" method="post" id="product-coa-form" accept-charset="UTF-8"> <div class="row"> <div class="col-12"> <h2>Certificate of Analysis</h2> <p>To download a Certificate of Analysis, please enter a lot number in the search box below.</p> <p><strong>Note:</strong> Certificate of Analysis not available for kit components.</p> </div> </div> <section class="row"> <div class="col-md-6"> <form novalidate="novalidate" data-drupal-selector="product-coa-form"> <div class="form-row align-items-center"> <div class="col-md-10 my-1"> <input data-drupal-selector="form-eabonscgaht6kxwczwjwrllo-c0h0iihk8f1i1jrcna" type="hidden" name="form_build_id" value="form-EabOnSCgaHT6KXwCzwJwRLLo_c0h0Iihk8f1i1jrcnA" /> <input data-drupal-selector="edit-product-coa-form" type="hidden" name="form_id" value="product_coa_form" /> <input data-drupal-selector="edit-product-code" type="hidden" name="product_code" value="215-GMP" /> <div class="js-form-item form-item pb-3 js-form-type-textfield form-item-lot-number js-form-item-lot-number form-no-label"> <input autocomplete="off" class="form-control cofa-lookup form-text" id="lot-number" placeholder="Search by lot number" data-drupal-selector="edit-lot-number" type="text" name="lot_number" value="" size="60" maxlength="128" /> </div> <input data-drupal-selector="edit-brand" type="hidden" name="brand" value="rnd" /> <input data-drupal-selector="edit-document-category" type="hidden" name="document_category" value="coa" /> </div> <div class="col-auto mb-3"> <input id="edit-submit" class="btn btn-primary cofa-btn button js-form-submit form-submit" data-drupal-selector="edit-submit" type="submit" name="op" value="Submit" /> </div> </div> </form> </div> <div id="pdf-result-rnd" class="col-md-6 mb-4 pdf-result datasheet-loading"></div> </section> </form> </div> </div> <div class="card-header"> <a class="collapsed" data-toggle="collapse" data-target="#collapse_three" aria-expanded="false" aria-controls="collapse_three" > <h5 class="mb-0"> SDS </h5> </a> </div> <div id="collapse_three" class="collapse rounded-bottom" aria-labelledby="heading_three" data-parent="#accordion"> <div class="card-body"> <div class="row sds-row"> <div class="select_wrapper col"> <select class="sds_country_select dropdown-chevron form-control mb-2" data-uri="https://aero.bio-techne.com/sds/pdf/215-gmp"> <option value="">Select SDS Language</option> <option value="cs-cz">Czech</option> <option value="da-dk">Danish</option> <option value="nl-nl">Dutch</option> <option value="en-us">English</option> <option value="de-de">German</option> <option value="fr-fr">French</option> <option value="hu-hu">Hungarian</option> <option value="it-it">Italian</option> <option value="nb-no">Norwegian</option> <option value="pl-pl">Polish</option> <option value="es-es">Spanish</option> <option value="sv-se">Swedish</option> </select> <span class="sds-pdf-result datasheet-loading"></span> </div> <div class="col my-3 pt-1 text-center text-lg-left"> <a class="sds-link datasheet_link datasheet-button-link text-wrap text-bt-blue" > Download SDS </a> </div> </div> </div> </div> </div> </div> <div id="manufacturing-specifications" class="py-5 bt-pp-border-bottom" data-section="section-base--manufacturing-specifications"> <h3>Manufacturing Specifications</h3> GMP Proteins<br> R&D Systems, a Bio-Techne Brand's GMP proteins are produced according to relevant sections of the following documents: USP Chapter 1043, Ancillary Materials for Cell, Gene and Tissue-Engineered Products and Eu. Ph. 5.2.12, Raw Materials of Biological Origin for the Production of Cell-based and Gene Therapy Medicinal Products. <br><br> R&D Systems' quality focus includes: <br><br><ul><li>Manufactured and tested under an ISO 9001:2015 and ISO 13485:2016 certified quality system</li><li>Documented processes and QA control of documentation and process changes</li><li>Personnel training programs</li><li>Raw material testing and vendor qualification/monitoring</li><li>Fully validated equipment, processes and test methods</li><li>Equipment calibration schedules using a computerized calibration program</li><li>Facility maintenance, safety programs and pest control</li><li>Material review process for variances</li><li>Monitoring of stability over product shelf-life<br><br></li></ul> R&D Systems strives to provide our customers with the analytical characteristics of each product so that customers may determine whether our products are appropriate for their research. The Certificate of Analysis provided contains the following lot specific information: <br><br><ul><li>N-terminal amino acid analysis, SDS-PAGE analysis, and endotoxin level (as determined by LAL assay) performed on each bulk QC lot, not on individual bottlings of each QC lot</li><li>Post-bottling lot-specific bioassay results (compliance with an established range) and results of microbial testing according to USP</li><li>Host Cell Protein testing performed by ELISA</li><li>Mycoplasma testing by ribosomal RNA hybridization assay<br><br></li></ul>Additional testing and documentation requested by the customer can be arranged at an additional cost. <br><br> Production records and facilities are available for examination by appropriate personnel on-site at R&D Systems in Minneapolis, Minnesota USA. <br><br> R&D Systems sells GMP grade products for preclinical or clinical <em>ex vivo</em> use. They are not for <em>in vivo</em> use. Please read the following End User Terms prior to using this product.<br><br>Animal-Free Manufacturing Conditions<br> Our dedicated controlled-access animal-free laboratories ensure that at no point in production are the products exposed to potential contamination by animal components or byproducts. Every stage of manufacturing is conducted in compliance with R&D Systems' stringent Standard Operating Procedures (SOPs). Production and purification procedures use equipment and media that are confirmed animal-free.   <br><br>Production <br><br><ul> <li>All molecular biology procedures use animal-free media and dedicated labware.</li> <li>Dedicated fermentors are utilized in committed animal-free areas.<br><br></li> </ul> Purification <br><br><ul> <li>Protein purification columns are animal-free.</li> <li>Bulk proteins are filtered using animal-free filters.</li> <li>Purified proteins are stored in animal-free containers in a dedicated cold storage room. </li></ul><br>Quality Assurance <br><br><ul><li>Low Endotoxin Level.</li><li>No impairment of biological activity. </li><li>High quality product obtained under stringent conditions. </li></ul><br><a target="_blank" href="https://www.rndsystems.com/products/animal-free-statement">Please read our complete Animal-Free Statement.</a> </div> <div id="specific-notices" class="py-5" data-section="section-base--specific-notices"> <h3>Product Specific Notices for Recombinant Human GM-CSF GMP Protein, CF </h3> <p></p><p><strong>END USER TERMS OF USE OF PRODUCT</strong></p> <p>The following terms are offered to you upon your acceptance of these End User Terms of Use of Product. By using this product, you indicate your acknowledgment and agreement to these End User Terms of Use of Product. If you do not agree to be bound by and comply with all of the provisions of these End User Terms of Use of Product, you should contact your supplier of the product and make arrangements to return the product.</p> <p>We suggest you print and retain a copy of these End User Terms of Use of Product for your records.</p> <p>The End User is aware that R&D Systems, Inc. sells GMP products for preclinical or clinical <em>ex vivo</em> use and not for <em>in vivo</em> use. The End User further agrees, as a condition of the sale of R&D Systems' GMP products that: a) the End User will not use this GMP Product in any procedure wherein the product may be directly or indirectly administered to humans, unless the End User has obtained, or prior to their use will have obtained, an Investigational New Drug (IND) exemption from the FDA and will use the product only in accordance with the protocols of such IND and of the Institutional Review Board overseeing the proposed research, or b) the End User will use the products outside of the United States in accordance with the protocols of research approved by the Institutional Review Board or authorized ethics committee and regulatory agencies to which the End User is subject to in their territory.</p> <p>R&D Systems, Inc. has the right, at its sole discretion, to modify, add or remove any terms or conditions of these End User Terms of Use without notice or liability to you. Any changes to these End User Terms of Use are effective immediately following the printing of such changes on this product insert. The most recent version of these End User Terms of Use of Product may be found at: RnDSystems.com/Legal.</p> <p>You agree to review these End User Terms of Use of Product to ensure any subsequent use by you of R&D Systems' GMP Products following changes to these End User Terms of Use of Product constitutes your acceptance of all such changes.</p> <p> </p> <p><strong>TERMS AND CONDITIONS</strong></p> <p>The following limitation applies to R&D Systems' warranty and liability for damages: All products are warranted to meet R&D Systems' published specifications when used under normal laboratory conditions.</p> <p>R&D SYSTEMS DOES NOT MAKE ANY OTHER WARRANTY OR REPRESENTATION WHATSOEVER, WHETHER EXPRESS OR IMPLIED, WITH RESPECT TO ITS PRODUCTS. IN PARTICULAR, R&D SYSTEMS DOES NOT MAKE ANY WARRANTY OF SUITABILITY, NONINFRINGEMENT, MERCHANTABILITY OR FITNESS FOR ANY PARTICULAR PURPOSE.</p> <p>NOTWITHSTANDING ANY OTHER PROVISIONS OF THESE TERMS AND/OR ANY OTHER AGREEMENT BETWEEN R&D SYSTEMS AND PURCHASER FOR THE PURCHASE OF THE PRODUCTS, R&D SYSTEMS' TOTAL LIABILITY TO PURCHASER ARISING FROM OR IN RELATION TO THESE TERMS, AN AGREEMENT BETWEEN THE PARTIES OR THE PRODUCTS, WHETHER ARISING IN CONTRACT, TORT OR OTHERWISE SHALL BE LIMITED TO THE TOTAL AMOUNT PAID BY PURCHASER TO R&D SYSTEMS FOR THE APPLICABLE PRODUCTS. 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