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</div> <div class="control"> <button class="button is-small is-link">Go</button> </div> </div> </form> </div> </div> <ol class="breathe-horizontal" start="1"> <li class="arxiv-result"> <div class="is-marginless"> <p class="list-title is-inline-block"><a href="https://arxiv.org/abs/1710.04195">arXiv:1710.04195</a> <span> [<a href="https://arxiv.org/pdf/1710.04195">pdf</a>, <a href="https://arxiv.org/format/1710.04195">other</a>] </span> </p> <div class="tags is-inline-block"> <span class="tag is-small is-link tooltip is-tooltip-top" data-tooltip="Tissues and Organs">q-bio.TO</span> <span class="tag is-small is-grey tooltip is-tooltip-top" data-tooltip="Biological Physics">physics.bio-ph</span> <span class="tag is-small is-grey tooltip is-tooltip-top" data-tooltip="Data Analysis, Statistics and Probability">physics.data-an</span> <span class="tag is-small is-grey tooltip is-tooltip-top" data-tooltip="Populations and Evolution">q-bio.PE</span> </div> <div class="is-inline-block" style="margin-left: 0.5rem"> <div class="tags has-addons"> <span class="tag is-dark is-size-7">doi</span> <span class="tag is-light is-size-7"><a class="" href="https://doi.org/10.1103/PhysRevE.98.050401">10.1103/PhysRevE.98.050401 <i class="fa fa-external-link" aria-hidden="true"></i></a></span> </div> </div> </div> <p class="title is-5 mathjax"> Extreme value statistics of mutation accumulation in renewing cell populations </p> <p class="authors"> <span class="search-hit">Authors:</span> <a href="/search/physics?searchtype=author&query=Greulich%2C+P">Philip Greulich</a>, <a href="/search/physics?searchtype=author&query=Simons%2C+B+D">Benjamin D. Simons</a> </p> <p class="abstract mathjax"> <span class="has-text-black-bis has-text-weight-semibold">Abstract</span>: <span class="abstract-short has-text-grey-dark mathjax" id="1710.04195v1-abstract-short" style="display: inline;"> The emergence of a predominant phenotype within a cell population is often triggered by a rare accumulation of DNA mutations in a single cell. For example, tumors may be initiated by a single cell in which multiple mutations cooperate to bypass a cell's defense mechanisms. The risk of such an event is thus determined by the extremal accumulation of mutations across tissue cells. To address this ri… <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('1710.04195v1-abstract-full').style.display = 'inline'; document.getElementById('1710.04195v1-abstract-short').style.display = 'none';">▽ More</a> </span> <span class="abstract-full has-text-grey-dark mathjax" id="1710.04195v1-abstract-full" style="display: none;"> The emergence of a predominant phenotype within a cell population is often triggered by a rare accumulation of DNA mutations in a single cell. For example, tumors may be initiated by a single cell in which multiple mutations cooperate to bypass a cell's defense mechanisms. The risk of such an event is thus determined by the extremal accumulation of mutations across tissue cells. To address this risk, we study the statistics of the maximum mutation numbers in a generic, but tested, model of a renewing cell population. By drawing an analogy between the genealogy of a cell population and the theory of branching random walks, we obtain analytical estimates for the probability of exceeding a threshold number of mutations and determine how the statistical distribution of maximum mutation numbers scales with age and cell population size. <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('1710.04195v1-abstract-full').style.display = 'none'; document.getElementById('1710.04195v1-abstract-short').style.display = 'inline';">△ Less</a> </span> </p> <p class="is-size-7"><span class="has-text-black-bis has-text-weight-semibold">Submitted</span> 11 October, 2017; <span class="has-text-black-bis has-text-weight-semibold">originally announced</span> October 2017. </p> <p class="comments is-size-7"> <span class="has-text-black-bis has-text-weight-semibold">Comments:</span> <span class="has-text-grey-dark mathjax">5 pages, 4 figures, under review at Physical Review Letters</span> </p> <p class="comments is-size-7"> <span class="has-text-black-bis has-text-weight-semibold">Journal ref:</span> Phys. Rev. E 98, 050401 (2018) </p> </li> <li class="arxiv-result"> <div class="is-marginless"> <p class="list-title is-inline-block"><a href="https://arxiv.org/abs/1608.03511">arXiv:1608.03511</a> <span> [<a href="https://arxiv.org/pdf/1608.03511">pdf</a>, <a href="https://arxiv.org/format/1608.03511">other</a>] </span> </p> <div class="tags is-inline-block"> <span class="tag is-small is-link tooltip is-tooltip-top" data-tooltip="Quantum Physics">quant-ph</span> <span class="tag is-small is-grey tooltip is-tooltip-top" data-tooltip="Cryptography and Security">cs.CR</span> <span class="tag is-small is-grey tooltip is-tooltip-top" data-tooltip="Emerging Technologies">cs.ET</span> <span class="tag is-small is-grey tooltip is-tooltip-top" data-tooltip="Atmospheric and Oceanic Physics">physics.ao-ph</span> <span class="tag is-small is-grey tooltip is-tooltip-top" data-tooltip="Optics">physics.optics</span> </div> <div class="is-inline-block" style="margin-left: 0.5rem"> <div class="tags has-addons"> <span class="tag is-dark is-size-7">doi</span> <span class="tag is-light is-size-7"><a class="" href="https://doi.org/10.1364/OPTICA.4.000611">10.1364/OPTICA.4.000611 <i class="fa fa-external-link" aria-hidden="true"></i></a></span> </div> </div> </div> <p class="title is-5 mathjax"> Quantum-limited measurements of optical signals from a geostationary satellite </p> <p class="authors"> <span class="search-hit">Authors:</span> <a href="/search/physics?searchtype=author&query=G%C3%BCnthner%2C+K">Kevin G眉nthner</a>, <a href="/search/physics?searchtype=author&query=Khan%2C+I">Imran Khan</a>, <a href="/search/physics?searchtype=author&query=Elser%2C+D">Dominique Elser</a>, <a href="/search/physics?searchtype=author&query=Stiller%2C+B">Birgit Stiller</a>, <a href="/search/physics?searchtype=author&query=Bayraktar%2C+%C3%96">脰mer Bayraktar</a>, <a href="/search/physics?searchtype=author&query=M%C3%BCller%2C+C+R">Christian R. M眉ller</a>, <a href="/search/physics?searchtype=author&query=Saucke%2C+K">Karen Saucke</a>, <a href="/search/physics?searchtype=author&query=Tr%C3%B6ndle%2C+D">Daniel Tr枚ndle</a>, <a href="/search/physics?searchtype=author&query=Heine%2C+F">Frank Heine</a>, <a href="/search/physics?searchtype=author&query=Seel%2C+S">Stefan Seel</a>, <a href="/search/physics?searchtype=author&query=Greulich%2C+P">Peter Greulich</a>, <a href="/search/physics?searchtype=author&query=Zech%2C+H">Herwig Zech</a>, <a href="/search/physics?searchtype=author&query=G%C3%BCtlich%2C+B">Bj枚rn G眉tlich</a>, <a href="/search/physics?searchtype=author&query=Philipp-May%2C+S">Sabine Philipp-May</a>, <a href="/search/physics?searchtype=author&query=Marquardt%2C+C">Christoph Marquardt</a>, <a href="/search/physics?searchtype=author&query=Leuchs%2C+G">Gerd Leuchs</a> </p> <p class="abstract mathjax"> <span class="has-text-black-bis has-text-weight-semibold">Abstract</span>: <span class="abstract-short has-text-grey-dark mathjax" id="1608.03511v2-abstract-short" style="display: inline;"> The measurement of quantum signals that traveled through long distances is of fundamental and technological interest. We present quantum-limited coherent measurements of optical signals, sent from a satellite in geostationary Earth orbit to an optical ground station. We bound the excess noise that the quantum states could have acquired after having propagated 38600 km through Earth's gravitational… <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('1608.03511v2-abstract-full').style.display = 'inline'; document.getElementById('1608.03511v2-abstract-short').style.display = 'none';">▽ More</a> </span> <span class="abstract-full has-text-grey-dark mathjax" id="1608.03511v2-abstract-full" style="display: none;"> The measurement of quantum signals that traveled through long distances is of fundamental and technological interest. We present quantum-limited coherent measurements of optical signals, sent from a satellite in geostationary Earth orbit to an optical ground station. We bound the excess noise that the quantum states could have acquired after having propagated 38600 km through Earth's gravitational potential as well as its turbulent atmosphere. Our results indicate that quantum communication is feasible in principle in such a scenario, highlighting the possibility of a global quantum key distribution network for secure communication. <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('1608.03511v2-abstract-full').style.display = 'none'; document.getElementById('1608.03511v2-abstract-short').style.display = 'inline';">△ Less</a> </span> </p> <p class="is-size-7"><span class="has-text-black-bis has-text-weight-semibold">Submitted</span> 27 February, 2017; <span class="has-text-black-bis has-text-weight-semibold">v1</span> submitted 11 August, 2016; <span class="has-text-black-bis has-text-weight-semibold">originally announced</span> August 2016. </p> <p class="comments is-size-7"> <span class="has-text-black-bis has-text-weight-semibold">Comments:</span> <span class="has-text-grey-dark mathjax">8 pages (4 pages main article, 4 pages supplementary material), 9 figures (4 figures main article, 5 figures supplementary material), Kevin G眉nthner and Imran Khan contributed equally to this work</span> </p> <p class="comments is-size-7"> <span class="has-text-black-bis has-text-weight-semibold">Journal ref:</span> Optica 4, 611-616 (2017) </p> </li> <li class="arxiv-result"> <div class="is-marginless"> <p class="list-title is-inline-block"><a href="https://arxiv.org/abs/1510.04507">arXiv:1510.04507</a> <span> [<a href="https://arxiv.org/pdf/1510.04507">pdf</a>] </span> </p> <div class="tags is-inline-block"> <span class="tag is-small is-link tooltip is-tooltip-top" data-tooltip="Quantum Physics">quant-ph</span> <span class="tag is-small is-grey tooltip is-tooltip-top" data-tooltip="Cryptography and Security">cs.CR</span> <span class="tag is-small is-grey tooltip is-tooltip-top" data-tooltip="Emerging Technologies">cs.ET</span> <span class="tag is-small is-grey tooltip is-tooltip-top" data-tooltip="Atmospheric and Oceanic Physics">physics.ao-ph</span> <span class="tag is-small is-grey tooltip is-tooltip-top" data-tooltip="Optics">physics.optics</span> </div> <div class="is-inline-block" style="margin-left: 0.5rem"> <div class="tags has-addons"> <span class="tag is-dark is-size-7">doi</span> <span class="tag is-light is-size-7"><a class="" href="https://doi.org/10.1109/ICSOS.2015.7425077">10.1109/ICSOS.2015.7425077 <i class="fa fa-external-link" aria-hidden="true"></i></a></span> </div> </div> </div> <p class="title is-5 mathjax"> Satellite Quantum Communication via the Alphasat Laser Communication Terminal </p> <p class="authors"> <span class="search-hit">Authors:</span> <a href="/search/physics?searchtype=author&query=Elser%2C+D">Dominique Elser</a>, <a href="/search/physics?searchtype=author&query=G%C3%BCnthner%2C+K">Kevin G眉nthner</a>, <a href="/search/physics?searchtype=author&query=Khan%2C+I">Imran Khan</a>, <a href="/search/physics?searchtype=author&query=Stiller%2C+B">Birgit Stiller</a>, <a href="/search/physics?searchtype=author&query=Marquardt%2C+C">Christoph Marquardt</a>, <a href="/search/physics?searchtype=author&query=Leuchs%2C+G">Gerd Leuchs</a>, <a href="/search/physics?searchtype=author&query=Saucke%2C+K">Karen Saucke</a>, <a href="/search/physics?searchtype=author&query=Tr%C3%B6ndle%2C+D">Daniel Tr枚ndle</a>, <a href="/search/physics?searchtype=author&query=Heine%2C+F">Frank Heine</a>, <a href="/search/physics?searchtype=author&query=Seel%2C+S">Stefan Seel</a>, <a href="/search/physics?searchtype=author&query=Greulich%2C+P">Peter Greulich</a>, <a href="/search/physics?searchtype=author&query=Zech%2C+H">Herwig Zech</a>, <a href="/search/physics?searchtype=author&query=G%C3%BCtlich%2C+B">Bj枚rn G眉tlich</a>, <a href="/search/physics?searchtype=author&query=Richter%2C+I">Ines Richter</a>, <a href="/search/physics?searchtype=author&query=Meyer%2C+R">Rolf Meyer</a> </p> <p class="abstract mathjax"> <span class="has-text-black-bis has-text-weight-semibold">Abstract</span>: <span class="abstract-short has-text-grey-dark mathjax" id="1510.04507v1-abstract-short" style="display: inline;"> By harnessing quantum effects, we nowadays can use encryption that is in principle proven to withstand any conceivable attack. These fascinating quantum features have been implemented in metropolitan quantum networks around the world. In order to interconnect such networks over long distances, optical satellite communication is the method of choice. Standard telecommunication components allow one… <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('1510.04507v1-abstract-full').style.display = 'inline'; document.getElementById('1510.04507v1-abstract-short').style.display = 'none';">▽ More</a> </span> <span class="abstract-full has-text-grey-dark mathjax" id="1510.04507v1-abstract-full" style="display: none;"> By harnessing quantum effects, we nowadays can use encryption that is in principle proven to withstand any conceivable attack. These fascinating quantum features have been implemented in metropolitan quantum networks around the world. In order to interconnect such networks over long distances, optical satellite communication is the method of choice. Standard telecommunication components allow one to efficiently implement quantum communication by measuring field quadratures (continuous variables). This opens the possibility to adapt our Laser Communication Terminals (LCTs) to quantum key distribution (QKD). First satellite measurement campaigns are currently validating our approach. <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('1510.04507v1-abstract-full').style.display = 'none'; document.getElementById('1510.04507v1-abstract-short').style.display = 'inline';">△ Less</a> </span> </p> <p class="is-size-7"><span class="has-text-black-bis has-text-weight-semibold">Submitted</span> 15 October, 2015; <span class="has-text-black-bis has-text-weight-semibold">originally announced</span> October 2015. </p> <p class="comments is-size-7"> <span class="has-text-black-bis has-text-weight-semibold">Comments:</span> <span class="has-text-grey-dark mathjax">International Conference on Space Optical Systems and Applications (IEEE ICSOS 2015), October 27 and 28, 2015, New Orleans, USA, 4 pages, 5 figures</span> </p> </li> <li class="arxiv-result"> <div class="is-marginless"> <p class="list-title is-inline-block"><a href="https://arxiv.org/abs/1202.5431">arXiv:1202.5431</a> <span> [<a href="https://arxiv.org/pdf/1202.5431">pdf</a>, <a href="https://arxiv.org/ps/1202.5431">ps</a>, <a href="https://arxiv.org/format/1202.5431">other</a>] </span> </p> <div class="tags is-inline-block"> <span class="tag is-small is-link tooltip is-tooltip-top" data-tooltip="Populations and Evolution">q-bio.PE</span> <span class="tag is-small is-grey tooltip is-tooltip-top" data-tooltip="Biological Physics">physics.bio-ph</span> </div> <div class="is-inline-block" style="margin-left: 0.5rem"> <div class="tags has-addons"> <span class="tag is-dark is-size-7">doi</span> <span class="tag is-light is-size-7"><a class="" href="https://doi.org/10.1103/PhysRevLett.109.088101">10.1103/PhysRevLett.109.088101 <i class="fa fa-external-link" aria-hidden="true"></i></a></span> </div> </div> </div> <p class="title is-5 mathjax"> Mutational pathway determines whether drug gradients accelerate evolution of drug-resistant cells </p> <p class="authors"> <span class="search-hit">Authors:</span> <a href="/search/physics?searchtype=author&query=Greulich%2C+P">Philip Greulich</a>, <a href="/search/physics?searchtype=author&query=Waclaw%2C+B">Bartlomiej Waclaw</a>, <a href="/search/physics?searchtype=author&query=Allen%2C+R+J">Rosalind J. Allen</a> </p> <p class="abstract mathjax"> <span class="has-text-black-bis has-text-weight-semibold">Abstract</span>: <span class="abstract-short has-text-grey-dark mathjax" id="1202.5431v4-abstract-short" style="display: inline;"> Drug gradients are believed to play an important role in the evolution of bacteria resistant to antibiotics and tumors resistant to anti-cancer drugs. We use a statistical physics model to study the evolution of a population of malignant cells exposed to drug gradients, where drug resistance emerges via a mutational pathway involving multiple mutations. We show that a non-uniform drug distribution… <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('1202.5431v4-abstract-full').style.display = 'inline'; document.getElementById('1202.5431v4-abstract-short').style.display = 'none';">▽ More</a> </span> <span class="abstract-full has-text-grey-dark mathjax" id="1202.5431v4-abstract-full" style="display: none;"> Drug gradients are believed to play an important role in the evolution of bacteria resistant to antibiotics and tumors resistant to anti-cancer drugs. We use a statistical physics model to study the evolution of a population of malignant cells exposed to drug gradients, where drug resistance emerges via a mutational pathway involving multiple mutations. We show that a non-uniform drug distribution has the potential to accelerate the emergence of resistance when the mutational pathway involves a long sequence of mutants with increasing resistance, but if the pathway is short or crosses a fitness valley, the evolution of resistance may actually be slowed down by drug gradients. These predictions can be verified experimentally, and may help to improve strategies for combatting the emergence of resistance. <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('1202.5431v4-abstract-full').style.display = 'none'; document.getElementById('1202.5431v4-abstract-short').style.display = 'inline';">△ Less</a> </span> </p> <p class="is-size-7"><span class="has-text-black-bis has-text-weight-semibold">Submitted</span> 15 August, 2012; <span class="has-text-black-bis has-text-weight-semibold">v1</span> submitted 24 February, 2012; <span class="has-text-black-bis has-text-weight-semibold">originally announced</span> February 2012. </p> <p class="comments is-size-7"> <span class="has-text-black-bis has-text-weight-semibold">Comments:</span> <span class="has-text-grey-dark mathjax">6 pages, 3 figures, final version before acceptance to Phys. Rev. Letters. P.G and B.W contributed equally to this work</span> </p> <p class="comments is-size-7"> <span class="has-text-black-bis has-text-weight-semibold">Journal ref:</span> Phys. Rev. Lett. 109, 088101 (2012) </p> </li> <li class="arxiv-result"> <div class="is-marginless"> <p class="list-title is-inline-block"><a href="https://arxiv.org/abs/1106.5733">arXiv:1106.5733</a> <span> [<a href="https://arxiv.org/pdf/1106.5733">pdf</a>, <a href="https://arxiv.org/format/1106.5733">other</a>] </span> </p> <div class="tags is-inline-block"> <span class="tag is-small is-link tooltip is-tooltip-top" data-tooltip="Biological Physics">physics.bio-ph</span> <span class="tag is-small is-grey tooltip is-tooltip-top" data-tooltip="Subcellular Processes">q-bio.SC</span> </div> <div class="is-inline-block" style="margin-left: 0.5rem"> <div class="tags has-addons"> <span class="tag is-dark is-size-7">doi</span> <span class="tag is-light is-size-7"><a class="" href="https://doi.org/10.1103/PhysRevE.84.060902">10.1103/PhysRevE.84.060902 <i class="fa fa-external-link" aria-hidden="true"></i></a></span> </div> </div> </div> <p class="title is-5 mathjax"> Boundary-induced orientation of dynamic filament networks and vesicle agglomerations </p> <p class="authors"> <span class="search-hit">Authors:</span> <a href="/search/physics?searchtype=author&query=Greulich%2C+P">Philip Greulich</a>, <a href="/search/physics?searchtype=author&query=Santen%2C+L">Ludger Santen</a> </p> <p class="abstract mathjax"> <span class="has-text-black-bis has-text-weight-semibold">Abstract</span>: <span class="abstract-short has-text-grey-dark mathjax" id="1106.5733v1-abstract-short" style="display: inline;"> We find a statistical mechanism that can adjust orientations of intracellular filaments to cell geometry in absence of organizing centers. The effect is based on random and isotropic filament (de-)polymerization dynamics and is independent of filament interactions and explicit regulation. It can be understood by an analogy to electrostatics and appears to be induced by the confining boundaries; fo… <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('1106.5733v1-abstract-full').style.display = 'inline'; document.getElementById('1106.5733v1-abstract-short').style.display = 'none';">▽ More</a> </span> <span class="abstract-full has-text-grey-dark mathjax" id="1106.5733v1-abstract-full" style="display: none;"> We find a statistical mechanism that can adjust orientations of intracellular filaments to cell geometry in absence of organizing centers. The effect is based on random and isotropic filament (de-)polymerization dynamics and is independent of filament interactions and explicit regulation. It can be understood by an analogy to electrostatics and appears to be induced by the confining boundaries; for periodic boundary conditions no orientational bias emerges. Including active transport of particles, the model reproduces experimental observations of vesicle accumulations in transected axons. <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('1106.5733v1-abstract-full').style.display = 'none'; document.getElementById('1106.5733v1-abstract-short').style.display = 'inline';">△ Less</a> </span> </p> <p class="is-size-7"><span class="has-text-black-bis has-text-weight-semibold">Submitted</span> 28 June, 2011; <span class="has-text-black-bis has-text-weight-semibold">originally announced</span> June 2011. </p> <p class="comments is-size-7"> <span class="has-text-black-bis has-text-weight-semibold">Comments:</span> <span class="has-text-grey-dark mathjax">4 pages, 6 figures. Submitted to Physical Review Letters</span> </p> </li> <li class="arxiv-result"> <div class="is-marginless"> <p class="list-title is-inline-block"><a href="https://arxiv.org/abs/0904.3890">arXiv:0904.3890</a> <span> [<a href="https://arxiv.org/pdf/0904.3890">pdf</a>, <a href="https://arxiv.org/format/0904.3890">other</a>] </span> </p> <div class="tags is-inline-block"> <span class="tag is-small is-link tooltip is-tooltip-top" data-tooltip="Biological Physics">physics.bio-ph</span> <span class="tag is-small is-grey tooltip is-tooltip-top" data-tooltip="Computational Physics">physics.comp-ph</span> </div> </div> <p class="title is-5 mathjax"> Active transport and cluster formation on 2D networks </p> <p class="authors"> <span class="search-hit">Authors:</span> <a href="/search/physics?searchtype=author&query=Greulich%2C+P">Philip Greulich</a>, <a href="/search/physics?searchtype=author&query=Santen%2C+L">Ludger Santen</a> </p> <p class="abstract mathjax"> <span class="has-text-black-bis has-text-weight-semibold">Abstract</span>: <span class="abstract-short has-text-grey-dark mathjax" id="0904.3890v2-abstract-short" style="display: inline;"> We introduce a model for active transport on inhomogeneous networks embedded in a diffusive environment and investigate the formation of particle clusters. In the presence of a hard-core interaction, cluster sizes exhibit an algebraically decaying distribution in a large parameter regime, indicating the existence of clusters on all scales. The results are compared with a diffusion limited aggregat… <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('0904.3890v2-abstract-full').style.display = 'inline'; document.getElementById('0904.3890v2-abstract-short').style.display = 'none';">▽ More</a> </span> <span class="abstract-full has-text-grey-dark mathjax" id="0904.3890v2-abstract-full" style="display: none;"> We introduce a model for active transport on inhomogeneous networks embedded in a diffusive environment and investigate the formation of particle clusters. In the presence of a hard-core interaction, cluster sizes exhibit an algebraically decaying distribution in a large parameter regime, indicating the existence of clusters on all scales. The results are compared with a diffusion limited aggregation model and active transport on a regular network. For both models we observe aggregation of particles to clusters which are characterized by a finite size-scale if the relevant time-scales and particle densities are considered. <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('0904.3890v2-abstract-full').style.display = 'none'; document.getElementById('0904.3890v2-abstract-short').style.display = 'inline';">△ Less</a> </span> </p> <p class="is-size-7"><span class="has-text-black-bis has-text-weight-semibold">Submitted</span> 17 January, 2011; <span class="has-text-black-bis has-text-weight-semibold">v1</span> submitted 24 April, 2009; <span class="has-text-black-bis has-text-weight-semibold">originally announced</span> April 2009. </p> <p class="comments is-size-7"> <span class="has-text-black-bis has-text-weight-semibold">Comments:</span> <span class="has-text-grey-dark mathjax">replaced; phenomenological analysis added</span> </p> <p class="comments is-size-7"> <span class="has-text-black-bis has-text-weight-semibold">Journal ref:</span> Euro. Phys. J. E 32, p.191 (2010) </p> </li> <li class="arxiv-result"> <div class="is-marginless"> <p class="list-title is-inline-block"><a href="https://arxiv.org/abs/0801.2214">arXiv:0801.2214</a> <span> [<a href="https://arxiv.org/pdf/0801.2214">pdf</a>, <a href="https://arxiv.org/ps/0801.2214">ps</a>, <a href="https://arxiv.org/format/0801.2214">other</a>] </span> </p> <div class="tags is-inline-block"> <span class="tag is-small is-link tooltip is-tooltip-top" data-tooltip="Biological Physics">physics.bio-ph</span> <span class="tag is-small is-grey tooltip is-tooltip-top" data-tooltip="Statistical Mechanics">cond-mat.stat-mech</span> <span class="tag is-small is-grey tooltip is-tooltip-top" data-tooltip="Subcellular Processes">q-bio.SC</span> </div> <div class="is-inline-block" style="margin-left: 0.5rem"> <div class="tags has-addons"> <span class="tag is-dark is-size-7">doi</span> <span class="tag is-light is-size-7"><a class="" href="https://doi.org/10.1140/epjb/e2008-00073-5">10.1140/epjb/e2008-00073-5 <i class="fa fa-external-link" aria-hidden="true"></i></a></span> </div> </div> </div> <p class="title is-5 mathjax"> Intra-cellular traffic: bio-molecular motors on filamentary tracks </p> <p class="authors"> <span class="search-hit">Authors:</span> <a href="/search/physics?searchtype=author&query=Chowdhury%2C+D">Debashish Chowdhury</a>, <a href="/search/physics?searchtype=author&query=Basu%2C+A">Aakash Basu</a>, <a href="/search/physics?searchtype=author&query=Garai%2C+A">Ashok Garai</a>, <a href="/search/physics?searchtype=author&query=Greulich%2C+P">Philip Greulich</a>, <a href="/search/physics?searchtype=author&query=Nishinari%2C+K">Katsuhiro Nishinari</a>, <a href="/search/physics?searchtype=author&query=Schadschneider%2C+A">Andreas Schadschneider</a>, <a href="/search/physics?searchtype=author&query=Tripathi%2C+T">Tripti Tripathi</a> </p> <p class="abstract mathjax"> <span class="has-text-black-bis has-text-weight-semibold">Abstract</span>: <span class="abstract-short has-text-grey-dark mathjax" id="0801.2214v1-abstract-short" style="display: inline;"> Molecular motors are macromolecular complexes which use some form of input energy to perform mechanical work. The filamentary tracks, on which these motors move, are made of either proteins (e.g., microtubules) or nucleic acids (DNA or RNA). Often, many such motors move simultaneously on the same track and their collective properties have superficial similarities with vehicular traffic on highwa… <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('0801.2214v1-abstract-full').style.display = 'inline'; document.getElementById('0801.2214v1-abstract-short').style.display = 'none';">▽ More</a> </span> <span class="abstract-full has-text-grey-dark mathjax" id="0801.2214v1-abstract-full" style="display: none;"> Molecular motors are macromolecular complexes which use some form of input energy to perform mechanical work. The filamentary tracks, on which these motors move, are made of either proteins (e.g., microtubules) or nucleic acids (DNA or RNA). Often, many such motors move simultaneously on the same track and their collective properties have superficial similarities with vehicular traffic on highways. The models we have developed provide ``unified'' description: in the low-density limit, a model captures the transport properties of a single motor while, at higher densities the same model accounts for the collective spatio-temporal organization of interacting motors. By drawing analogy with vehicular traffic, we have introduced novel quantities for characterizing the nature of the spatio-temporal organization of molecular motors on their tracks. We show how the traffic-like intracellular collective phenomena depend on the mechano-chemistry of the corresponding individual motors. <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('0801.2214v1-abstract-full').style.display = 'none'; document.getElementById('0801.2214v1-abstract-short').style.display = 'inline';">△ Less</a> </span> </p> <p class="is-size-7"><span class="has-text-black-bis has-text-weight-semibold">Submitted</span> 14 January, 2008; <span class="has-text-black-bis has-text-weight-semibold">originally announced</span> January 2008. </p> <p class="comments is-size-7"> <span class="has-text-black-bis has-text-weight-semibold">Comments:</span> <span class="has-text-grey-dark mathjax">9 pages, 11 figures; Based on the invited talk delivered by the first author (DC) at the IUPAP International Conference STATPHYS23, Genoa (Italy), July, 2007</span> </p> <p class="comments is-size-7"> <span class="has-text-black-bis has-text-weight-semibold">Journal ref:</span> European Physical Journal B, vol. 64, p. 593 (2008). </p> </li> <li class="arxiv-result"> <div class="is-marginless"> <p class="list-title is-inline-block"><a href="https://arxiv.org/abs/physics/0612054">arXiv:physics/0612054</a> <span> [<a href="https://arxiv.org/pdf/physics/0612054">pdf</a>, <a href="https://arxiv.org/ps/physics/0612054">ps</a>, <a href="https://arxiv.org/format/physics/0612054">other</a>] </span> </p> <div class="tags is-inline-block"> <span class="tag is-small is-link tooltip is-tooltip-top" data-tooltip="Biological Physics">physics.bio-ph</span> <span class="tag is-small is-grey tooltip is-tooltip-top" data-tooltip="Statistical Mechanics">cond-mat.stat-mech</span> <span class="tag is-small is-grey tooltip is-tooltip-top" data-tooltip="Subcellular Processes">q-bio.SC</span> </div> <div class="is-inline-block" style="margin-left: 0.5rem"> <div class="tags has-addons"> <span class="tag is-dark is-size-7">doi</span> <span class="tag is-light is-size-7"><a class="" href="https://doi.org/10.1103/PhysRevE.75.041905">10.1103/PhysRevE.75.041905 <i class="fa fa-external-link" aria-hidden="true"></i></a></span> </div> </div> </div> <p class="title is-5 mathjax"> Intra-cellular transport by single-headed kinesin KIF1A: effects of single-motor mechano-chemistry and steric interactions </p> <p class="authors"> <span class="search-hit">Authors:</span> <a href="/search/physics?searchtype=author&query=Greulich%2C+P">Philip Greulich</a>, <a href="/search/physics?searchtype=author&query=Garai%2C+A">Ashok Garai</a>, <a href="/search/physics?searchtype=author&query=Nishinari%2C+K">Katsuhiro Nishinari</a>, <a href="/search/physics?searchtype=author&query=Schadschneider%2C+A">Andreas Schadschneider</a>, <a href="/search/physics?searchtype=author&query=Chowdhury%2C+D">Debashish Chowdhury</a> </p> <p class="abstract mathjax"> <span class="has-text-black-bis has-text-weight-semibold">Abstract</span>: <span class="abstract-short has-text-grey-dark mathjax" id="physics/0612054v3-abstract-short" style="display: inline;"> In eukaryotic cells, many motor proteins can move simultaneously on a single microtubule track. This leads to interesting collective phenomena like jamming. Recently we reported ({\it Phys. Rev. Lett. {\bf 95}, 118101 (2005)}) a lattice-gas model which describes traffic of unconventional (single-headed) kinesins KIF1A. Here we generalize this model, introducing a novel interaction parameter $c$,… <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('physics/0612054v3-abstract-full').style.display = 'inline'; document.getElementById('physics/0612054v3-abstract-short').style.display = 'none';">▽ More</a> </span> <span class="abstract-full has-text-grey-dark mathjax" id="physics/0612054v3-abstract-full" style="display: none;"> In eukaryotic cells, many motor proteins can move simultaneously on a single microtubule track. This leads to interesting collective phenomena like jamming. Recently we reported ({\it Phys. Rev. Lett. {\bf 95}, 118101 (2005)}) a lattice-gas model which describes traffic of unconventional (single-headed) kinesins KIF1A. Here we generalize this model, introducing a novel interaction parameter $c$, to account for an interesting mechano-chemical process which has not been considered in any earlier model. We have been able to extract all the parameters of the model, except $c$, from experimentally measured quantities. In contrast to earlier models of intra-cellular molecular motor traffic, our model assigns distinct ``chemical'' (or, conformational) states to each kinesin to account for the hydrolysis of ATP, the chemical fuel of the motor. Our model makes experimentally testable theoretical predictions. We determine the phase diagram of the model in planes spanned by experimentally controllable parameters, namely, the concentrations of kinesins and ATP. Furthermore, the phase-separated regime is studied in some detail using analytical methods and simulations to determine e.g. the position of shocks. Comparison of our theoretical predictions with experimental results is expected to elucidate the nature of the mechano-chemical process captured by the parameter $c$. <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('physics/0612054v3-abstract-full').style.display = 'none'; document.getElementById('physics/0612054v3-abstract-short').style.display = 'inline';">△ Less</a> </span> </p> <p class="is-size-7"><span class="has-text-black-bis has-text-weight-semibold">Submitted</span> 17 February, 2007; <span class="has-text-black-bis has-text-weight-semibold">v1</span> submitted 6 December, 2006; <span class="has-text-black-bis has-text-weight-semibold">originally announced</span> December 2006. </p> <p class="comments is-size-7"> <span class="has-text-black-bis has-text-weight-semibold">Comments:</span> <span class="has-text-grey-dark mathjax">17 pages including 14 embedded EPS figures; accepted for publication in Physical Review E</span> </p> <p class="comments is-size-7"> <span class="has-text-black-bis has-text-weight-semibold">Journal ref:</span> Physical Review E, vol.75, 041905 (2007). </p> </li> </ol> <div class="is-hidden-tablet">  <span class="help" style="display: inline-block;"><a href="https://github.com/arXiv/arxiv-search/releases">Search v0.5.6 released 2020-02-24</a>  </span> </div> </div> </main> <footer> <div class="columns is-desktop" role="navigation" aria-label="Secondary">  <div class="column"> <div class="columns"> <div class="column"> <ul class="nav-spaced"> <li><a href="https://info.arxiv.org/about">About</a></li> <li><a href="https://info.arxiv.org/help">Help</a></li> </ul> </div> <div class="column"> <ul class="nav-spaced"> <li> <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512" class="icon filter-black" role="presentation"><title>contact arXiv</title><desc>Click here to contact arXiv</desc><path d="M502.3 190.8c3.9-3.1 9.7-.2 9.7 4.7V400c0 26.5-21.5 48-48 48H48c-26.5 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