Trizyklika und verwandte Arzneimittel zur Behandlung von Bettnässen bei Kindern

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href="javascript:void(0)" class="menu-touch"> <div class="navbar-toggle"> <span></span> <span></span> <span></span> </div> </a> </div> </div> </div> </div> <div class="silaslite-logo"> <div class="inner-logo"> <h2 class="site-title"><a href="https://imagexinnovation.com/">Image & Innovation </a></h2> <span class="tag-line">Information</span> </div> </div> </div> </header> <div id="content" class="silaslite-primary"> <div class="main-contaier"> <div class="container"> <div class="row wrapper-main-content mx-n4"> <div class="main-content has-sidebar col px-4"> <div class="silaslite-single-post"> <article class="post-single post-52794 post type-post status-publish format-standard hentry category-articles"> <div class="post-inner"> <div class="post-header"> <div class="post-cats"><a href="https://imagexinnovation.com/category/articles/" rel="category tag">Articles</a></div> <h1 class="post-title">Cochrane (Deutsch)</h1> <div class="post-meta"> <div class="post-author"> <span>posted by: </span><a href="https://imagexinnovation.com/author/admin/" title="Beiträge von admin" rel="author">admin</a> </div> <div class="date-post"> <i class="far fa-clock"></i>Dezember 31, 2020 </div> </div> </div> <div class="post-info"> <div class="post-content"> <p>Vierundsechzig Studien erfüllten die Einschlusskriterien mit 4071 Kindern. Die Qualität vieler Studien war arm, den Vergleich angesprochen, die von einzelnen Studien. Geringfügige Nebenwirkungen waren häufig und wurden in 30 Studien berichtet. Dazu gehörten Schwindel, Kopfschmerzen, Stimmungsschwankungen, Magen-Darm-Beschwerden und Neutropenie. Schwerwiegendere Nebenwirkungen können auftreten, wurden aber nicht berichtet. Sieben Studien berichteten über keine Nebenwirkungen.</p> <p>Trizyklika sind wirksamer als Placebo, insbesondere für kurzfristige Ergebnisse., Im Vergleich zu Placebo führte Imipramin zu weniger nassen Nächten pro Woche (mittlere Differenz (MD) -0.95, 95% Konfidenzintervall (CI) -1.40 bis -0.50; 4 Studien, 347 Kinder), wobei weniger 14 aufeinanderfolgende trockene Nächte nicht erreichten (78% gegenüber 95% für Placebo, RR 0.74, 95% CI 0.61 bis 0.90; 12 Studien, 831 Kinder). Amitriptylin und Desipramin waren wirksamer als Placebo, aber Nortriptylin und Mianserin zeigten keinen Unterschied. Die meisten Trizyklika hatten nach Beendigung der Behandlung keine anhaltende Wirkung, wobei 96% bei der Nachuntersuchung nach Imipramin benetzt wurden, gegenüber 97% nach Placebo.,</p> <p>Es gab nicht genügend Beweise, um die Wirkung zwischen verschiedenen Dosen von Trizyklika und zwischen verschiedenen Trizyklika zu beurteilen. Die Behandlungsergebnisse zwischen trizyklisch und Desmopressin waren ähnlich, waren jedoch gemischt, wenn trizyklisch mit einem Anticholinergikum verglichen wurde. Wenn Imipramin jedoch mit Desmopressin plus Oxybutynin verglichen wurde (1 Studie, 45 Kinder), war die Kombinationstherapie wirksamer, wobei eine weniger nasse Nächte pro Woche (MD 1,07, 95% CI 0,06 bis 2,08) und 36% 14 aufeinanderfolgende trockene Nächte im Vergleich zu 87% für Imipramin nicht erreichten (RR 2,39, 95% CI 1,35 bis 4,25)., Trizyklika waren auch wirksamer oder zeigten keinen Unterschied in der Reaktion im Vergleich zu anderen Medikamenten, die nicht mehr für Enuresis verwendet werden.</p> <p>Trizyklika waren weniger wirksam als Alarme. Obwohl es keinen Unterschied in der Anzahl der nassen Nächte gab, konnten 67% 14 aufeinanderfolgende trockene Nächte für Imipramin gegenüber nur 17% für Alarme nicht erreichen (RR 4.00, 95% CI 1.06 bis 15.08; 1 Studie, 24 Kinder). Die Alarmtherapie hatte auch eine nachhaltigere Wirkung nach Beendigung der Behandlung mit 100% Imipramin gegenüber 58% bei der Alarmbenetzung bei der Nachsorge (RR 1, 67, 95% CI 1, 03 bis 2, 69; 1 Studie, 24 Kinder).,</p> <p></p> <p>Imipramin war wirksamer als einfache Verhaltenstherapien während der Behandlung, mit einer weniger nassen Nächte pro Woche im Vergleich zu Star Chart plus Placebo (MD -0,80, 95% CI -1,33 bis -0,27; 1 Studie, 250 Kinder). Bei der Nachuntersuchung wurden 40% mit Imipramin gegenüber 80% mit Flüssigkeiten behandelt und eine Bestrafung vermieden (RR 0, 50, 95% CI 0, 28 bis 0, 89; 1 Studie, 40 Kinder). Imipramin war jedoch weniger wirksam als komplexe Verhaltenstherapien, wobei 61% 14 aufeinanderfolgende trockene Nächte für Imipramin nicht erreichten, gegenüber 33% für das dreistufige Programm (RR 1.83, 95% CI 1.08 bis 3.,12; 1 Studie, 72 Kinder) und 16% für das dreistufige Programm in Kombination mit Motivationstherapie und computergeführter Ausbildung (RR 3.91, 95% CI 2.30 bis 6.66; 1 Studie, 132 Kinder) am Ende der Behandlung mit ähnlichen Ergebnissen bei der Nachsorge.</p> <p>Trizyklika waren wirksamer als eine eingeschränkte Ernährung, wobei 99% 14 aufeinanderfolgende trockene Nächte nicht erreichten, verglichen mit 84% für Imipramin (RR 0, 84, 95% CI 0, 75 bis 0, 93; 1 Studie, 147 Kinder).Es gab unzureichende Beweise, um die Wirkung von Trizyklika im Vergleich zu den anderen untersuchten verschiedenen Interventionen zu beurteilen.,</p> <p>Am Ende der Behandlung gab es etwa zwei weniger nasse Nächte für Imipramin plus Oxybutynin im Vergleich zur Imipramin-Monotherapie (MD -2.10, 95% CI -2.99 bis -1.21; 1 Studie, 63 Kinder) und 48% für Imipramin plus Oxybutynin konnten 14 aufeinanderfolgende trockene Nächte nicht erreichen, verglichen mit 74% für Imipramin-Monotherapie (RR 0.68, 95% CI 0.50 bis 0.92; 2 Studien, 101 Kinder). Bei der Nachuntersuchung wurden 45% unter Imipramin plus Oxybutynin benetzt gegenüber 83% unter Imipraminmonotherapie (RR 0.55, 95% CI 0.32 bis 0.92; 1 Studie, 36 Kinder).,</p> <p>Wenn Imipramin kombiniert mit Desmopressin mit Imipramin Monotherapie verglichen wurde, gab es keinen Unterschied in den Ergebnissen. Wenn jedoch Imipramin plus Desmopressin mit der Desmopressin-Monotherapie verglichen wurde, war die Kombination wirksamer, wobei 15% am Ende der Behandlung von Imipramin plus Desmopressin keine 14 aufeinanderfolgenden trockenen Nächte erreichten 40% für Desmopressin-Monotherapie (RR 0.38, 95% CI 0.17 bis 0.83; 1 Studie, 86 Kinder)., Trizyklika in Kombination mit Alarmtherapie waren nicht wirksamer als Alarmmonotherapie, Alarm in Kombination mit Desmopressin oder Alarm in Kombination mit Nortriptylin. Die Zugabe eines trizyklischen zu anderen Verhaltenstherapien änderte das Ansprechen auf die Behandlung nicht.</p> <p></p> </div> <div class="post-footer"> <div class="post-share-wrap"> <div class="post-share">  <a target="_blank" href="https://www.facebook.com/sharer/sharer.php?u=https://imagexinnovation.com/cochrane-16/"><i class="fab fa-facebook-f"></i></a> <a title="Click to share this post on Twitter" href="https://twitter.com/intent/tweet?text=Currently%20reading%20Cochrane%20(Deutsch)&url=https://imagexinnovation.com/cochrane-16/" target="_blank" rel="noopener noreferrer"> <i class="fab fa-twitter"></i> </a> <a target="_blank" href="https://pinterest.com/pin/create/button/?url=https://imagexinnovation.com/cochrane-16/&media=&description=Cochrane%20(Deutsch)"><i class="fab fa-pinterest"></i></a> <a target="_blank" href="http://www.linkedin.com/shareArticle?mini=true&url=https://imagexinnovation.com/cochrane-16/&title=Cochrane%20(Deutsch)&source=Image%20&%20Innovation"><i 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