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class="node-body"> <div class="group-section-0"> <div class="field field--name-field-project-logo field--type-image field--label-hidden field__items"> <div class="field__item"> <img loading="lazy" src="/sites/default/files/styles/medium/public/field_project_logo/logo_SFB-TR_128.jpg?itok=bkHocay2" width="220" height="92" alt="logo of CRC-TR 128" typeof="foaf:Image" /> </div> </div> </div> <div class="group-section-1"> <div class="slick blazy slick--field slick--field-project-image slick--field-project-image--full is-b-captioned unslick slick--optionset--default slick--less" data-blazy=""><div class="slide__content"><div class="slide__media"> <div data-b-token="b-76ec1f0abc8" class="media media--blazy media--slick media--image is-b-loading"><img alt="EGFL7 bindet Immunzellen im perivaskulären Raum in MS-Läsionen" title="EGFL7 bindet Immunzellen im perivaskulären Raum in MS-Läsionen (Bild: Timo Uphaus, AG Zipp)" decoding="async" class="media__element b-lazy" loading="lazy" data-src="/sites/default/files/field_project_image/SFB-TR_128.jpg" src="data:image/svg+xml;charset=utf-8,%3Csvg%20xmlns%3D'http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg'%20viewBox%3D'0%200%201%201'%2F%3E" width="650" height="366" typeof="foaf:Image" /> </div></div> <div class="blazy__caption slide__caption"><h2 class="slide__title">EGFL7 bindet Immunzellen im perivaskulären Raum in MS-Läsionen (Bild: Timo Uphaus, AG Zipp)</h2> </div></div> </div> <div class="field-global-text-long-column field field--name-field-project-text field--type-text-long field--label-hidden field__items"> <div class="field__item"><p>Die Multiple Sklerose (MS) ist in der westlichen Welt die häufigste chronisch-entzündliche Erkrankung des Zentralnervensystems. Allein in Deutschland sind mehr als 120.000 Menschen davon betroffen. Derzeit stehen jedoch nur begrenzte Behandlungsmöglichkeiten zur Verfügung. Grundlagen für die Entwicklung von neuen Therapien gegen Multiple Sklerose zu schaffen und existierende Therapiekonzepte besser zu verstehen, sind daher die zentralen Ziele des SFB/Transregio 128 "Initiierungs-, Effektor- und Regulationsmechanismen bei Multipler Sklerose – von einem neuen Verständnis der Pathogenese zur Therapie". Darüber hinaus wollen die Forscher herausfinden, auf welchem Weg die Multiple Sklerose entsteht.</p> <p><span><span><span></span></span></span></p> <p><span><span><span>Die Verknüpfung von Wissenschaftlerinnen und Wissenschaftlern aus benachbarten Gebieten mit klassischen Neuroimmunologen, die bereits anerkannt sind in der MS-Forschung und der Betreuung von MS-Patienten, bietet ideale Voraussetzungen für das Gelingen. Besonders wichtig ist dabei die starke bidirektionale Interaktion zwischen Grundlagen- und Klinischer Forschung, die den besten und effektivsten Transfer von Grundlagenwissen in die Klinik und umgekehrt erlaubt. </span></span></span></p> <p><span><span><span></span></span></span></p> <p><span><span><span>Im SFB/TRR 128 arbeiten Wissenschaftlerinnen und Wissenschaftler der Rhein-Main-Region sowie aus Münster und München zusammen. Wie auch der SFB 1193 ist der SFB/TRR 128 in das Forschungszentrum Translationale Neurowissenschaften (FTN) der JGU und das Rhine-Main Neuroscience Network (rmn²) eingebettet. Das Netzwerk rmn² koordiniert die zentralen Forschungsprojekte zur Aufklärung und Therapie von Hirnerkrankungen im Rhein-Main-Gebiet. </span></span></span></p> <p><span lang="EN-US"><span><span></span></span></span></p></div> </div><dl class="field-global-list field field--name-field-project-link field--type-link field--label-above field__items"> <dt class="field__label">Link zu Projekt-Website</dt> <dd class="field__item"><a href="http://www.sfbtr128.de/">Sonderforschungsbereich/Transregio 128: Initiierungs-/Effektor- und Regulations…</a></dd> </dl> </div> </div> </article> </div> </div> </div> </section> <section class="views-element-container block block-views block-views-block--story-block-5" id="block-views-block-story-block-5"> <div class="block-box-outer"> <div class="block-box-inner"> <header class="block-head"> <h2>Zugehörige News</h2> </header> <div class="block-body"> <div><div class="view-global-story-teaser view view-story view-id-story view-display-id-block_5 js-view-dom-id-0f45891c054e1f753574e732ffb67235c083f803bd0e0016984cad4654055fea"> <div class="view-content"> <div class="views-row"> <article about="/news/sonderforschungsbereich-mit-fokus-auf-multiple-sklerose-forschung-eingerichtet" class="node node--type-story node--id-132 node--view-mode-teaser"> <header class="node-head"> <h3><a href="/news/sonderforschungsbereich-mit-fokus-auf-multiple-sklerose-forschung-eingerichtet" rel="bookmark"> <span>Sonderforschungsbereich mit Fokus auf Multiple-Sklerose-Forschung eingerichtet</span> </a></h3> </header> <div class="node-body"> <div class="group-section-0"> <div class="field field--name-field-story-date field--type-datetime field--label-hidden field__items"> <p class="field__item"><time datetime="2012-05-25T12:00:00Z">25.05.2012</time> </p> </div><div class="field field--name-field-story-intro field--type-text-long field--label-hidden field__items"> <div class="field__item"><p>Die Deutsche Forschungsgemeinschaft (DFG) richtet zum 1. Juli 2012 einen neuen Sonderforschungsbereich/Transregio unter Koordination der Universitätsmedizin Mainz ein, der mit insgesamt rund 13,3 Millionen Euro für zunächst vier Jahre gefördert wird. Durch Gründung des Forschungsschwerpunkts Translationale Neurowissenschaften an der Johannes Gutenberg-Universität Mainz (JGU) und die Einbettung sämtlicher Forschungsprojekte zur Aufklärung und Therapie von Hirnerkrankungen in das neue Rhine-Main Neuroscience Network (rmn2) gemeinsam mit der Goethe-Universität Frankfurt am Main wurde die Grundlage für die erfolgreiche Durchführung dieses SFB/Transregio geschaffen. Beteiligt sind darüber hinaus die Westfälische Wilhelms-Universität Münster, die Ludwig-Maximilians-Universität München, die Technische Universität München sowie Max-Planck-Institute in München, Münster und Bad Nauheim.</p></div> </div> </div> <div class="group-section-2 group-collapsible-container collapsed"> <div class="field field--name-field-story-text field--type-text-long field--label-hidden field__items"> <div class="field__item"><p>Grundlagen für die Entwicklung neuer Therapien gegen Multiple Sklerose (MS) zu schaffen und existierende Therapiekonzepte besser zu verstehen, das sind die zentralen Ziele des SFB/Transregio 128 "Initiierungs-/Effektor- und Regulationsmechanismen bei Multipler Sklerose – von einem neuen Verständnis der Pathogenese zur Therapie". Darüber hinaus wollen die Forscher herausfinden, wie Multiple Sklerose entsteht. Das Verbundprojekt wird von der Direktorin der Klinik und Poliklinik für Neurologie der Universitätsmedizin Mainz, Prof. Dr. Frauke Zipp, als Sprecherin koordiniert.</p> <p>Multiple Sklerose ist in der westlichen Welt die häufigste chronisch-entzündliche Erkrankung des Zentralnervensystems. Allein in Deutschland sind mehr als 120.000 Menschen davon betroffen. "Viele Fragen etwa zur Entstehung dieser Autoimmunerkrankung sind nach wie vor ungeklärt. Der Schlüssel zu wirkungsvolleren Therapien liegt in der Grundlagenforschung und genau da setzt der innovative und interdisziplinäre Ansatz des SFB/TR 128 unter Sprecherschaft der Universitätsmedizin Mainz an", so der Wissenschaftliche Vorstand der Universitätsmedizin Mainz, Prof. Dr. Dr. Reinhard Urban. "Die Neustrukturierung unserer Forschungsschwerpunkte an der Universitätsmedizin Mainz trägt jetzt Früchte."</p> <p>"Das hohe Potenzial des SFB/Transregio 128 liegt darin begründet, dass wir exzellente Forscher benachbarter Wissenschaftsdisziplinen mit ins Boot holen. Dadurch betritt dieser Verbund neue Wege, die über die klassische Neuroimmunologie hinausgehen", so Zipp. Ein Schlüsselaspekt ist laut der Neurologin zudem, dass experimentelle Forschung und patientenorientierte klinische Forschung eng aufeinander abgestimmt sein werden.</p> <p>Prof. Dr. Frauke Zipp wechselte erst Ende 2009 von der Charité, Berlin, nach Mainz und sieht in der Bewilligung dieses Sonderforschungsbereichs einen wichtigen Schritt auf dem Weg, das Rhine-Main Neuroscience Network gemeinsam mit den Partnern in Münster und München zu einem internationalen Zentrum der MS-Forschung zu machen.</p></div> </div><dl class="field-global-list field field--name-field-story-link field--type-link field--label-above field__items"> <dt class="field__label">Links</dt> <dd class="field__item"><a href="http://www.sfbtr128.de/">Sonderforschungsbereich-Transregio 128</a></dd> </dl><dl class="field-global-list field-global-list-inline field field--name-field-story-rel-taxonomy-tags field--type-entity-reference field--label-above field__items"> <dt class="field__label">Tags</dt> <dd class="field__item"><a href="/news/tags/mainz" hreflang="de">Mainz</a></dd> <dd class="field__item"><a href="/news/tags/frankfurt" hreflang="de">Frankfurt</a></dd> </dl> </div> </div> </article> </div> </div> </div> </div> </div> </div> </div> </section> </main> </div> </div> </div> </div> <div class="page-foot"> <div class="page-foot-box-outer"> <div class="page-foot-box-inner"> <footer class="region region-footer"> <section class="views-element-container block-global-head-less block block-views block-views-block--organisation-block-1" id="block-views-block-organisation-block-1"> <div class="block-box-outer"> <div class="block-box-inner"> <header class="block-head"> <h2>Rhine-Main Universities</h2> </header> <div class="block-body"> <div><div class="view view-organisation view-id-organisation view-display-id-block_1 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