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Ciencia y terapia del cáncer | 3 | 2011

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class="animate-icon mx-3 stretched-link" href="https://www.scholarscentral.org/submissions/cancer-science-therapy.html" title="haga clic aqu铆" target="_blank"> <span target="_blank" class="animate-icon-horizontal"> <i class="material-icons animate-icon-horizontal-wrap animate-icon-left-to-right">arrow_forward</i> <i class="material-icons animate-icon-horizontal-wrap animate-icon-left-to-right">arrow_forward</i> </span> </a> <img src="/assets/img/manuscript.svg" alt=".." width="50"> </div> </div> <div class="mt-2 cu_whatsapp"> </div> </div> </div> </header> <section class="container"> <div class="row"> <div class="col-sm"> <h2 class="text-primary font-size-6 my-3 border-bottom-2 border-yellow-900 pb-2">Volumen 3, Asunto 1 (2011)</h2> <div class="border-bottom-1 py-2"> <div class="d-flex w-100 justify-content-between mb-1"> <span class="align-self-center"> Art铆culo de investigaci贸n </span> </div> <h3 class="mb-2 font-size-4"><a href="https://spanish.hilarispublisher.com/abstract/bronchial-sialadenoma-papilliferum-a-very-rare-cause-of-hemoptysis-38501.html" title="Sialadenoma papil&iacute;fero bronquial: una causa muy poco frecuente de hemoptisis ">Sialadenoma papil&iacute;fero bronquial: una causa muy poco frecuente de hemoptisis </a></h3> <p class="mb-2 font-size-3 text-muted"> <i class="fas fa-user"></i> Roger Fei. Falkenstern Ge, Ott G, Friedel G, Markmann HU, Kohlh&auml;ufl M y Kalla J </p> <div class="row justify-content-between align-items-center"> <div class="col pl-0"> <a class="btn btn-link" data-toggle="collapse" href="#collapseAbstract117169" role="button" aria-expanded="false" aria-controls="collapseAbstract"> Abstracto </a> </div> <div class="col-sm-auto"> <nav class="nav a-mx-2"> <a href="https://spanish.hilarispublisher.com/abstract/bronchial-sialadenoma-papilliferum-a-very-rare-cause-of-hemoptysis-38501.html" title="haga clic aqu铆" class="card-link border-bottom-2 yellow-900 border-yellow-900"><i class="fas fa-file-alt fa-lg"></i> Abstracto</a> </nav> </div> </div> <div class="collapse" id="collapseAbstract117169"> <div class="card card-body p-2 bg-light"><p><strong><font style="vertical-align: inherit;"><font style="vertical-align: inherit;">Objetivo:</font></font></strong><font style="vertical-align: inherit;"><font style="vertical-align: inherit;"> Este caso es el tercer caso de Sialadenoma papil&iacute;fero del sistema bronquial. Se trata de un tumor extremadamente raro del sistema bronquial. Este informe destaca una vez m&aacute;s las dificultades histopatol&oacute;gicas que supone el diagn&oacute;stico de un tumor tan poco frecuente.</font></font></p> <p><strong><font style="vertical-align: inherit;"><font style="vertical-align: inherit;">Pacientes y m&eacute;todos:</font></font></strong><font style="vertical-align: inherit;"><font style="vertical-align: inherit;"> Una mujer de 53 a&ntilde;os con antecedentes de 3 semanas de tos productiva asociada a hemoptisis acudi&oacute; al hospital comunitario de Stuttgart (Hospital docente de la Universidad de T&uuml;bingen). Una TC tor&aacute;cica revel&oacute; una masa s&oacute;lida en el l&oacute;bulo inferior derecho de 10 mm de di&aacute;metro. En el hospital comunitario, una biopsia broncosc&oacute;pica result&oacute; sospechosa de un adenocarcinoma de pulm&oacute;n.</font></font></p> <p><strong><font style="vertical-align: inherit;"><font style="vertical-align: inherit;">Resultado:</font></font></strong><font style="vertical-align: inherit;"><font style="vertical-align: inherit;"> El paciente fue trasladado a nuestra instituci&oacute;n para cirug&iacute;a tor&aacute;cica y se realiz&oacute; una bilobectom&iacute;a inferior derecha con resecci&oacute;n de vasos intraperic&aacute;rdicos semicirculares y resecci&oacute;n ganglionar total. Mediante an&aacute;lisis inmunohistoqu&iacute;mico, el tumor extirpado (tama&ntilde;o 10 mm) revel&oacute; ser un adenoma benigno de las gl&aacute;ndulas bronquiales seromucosas, que es un tumor benigno muy raro del tipo Sialadenoma papilliferum. Todos los ganglios linf&aacute;ticos extirpados fueron analizados y no mostraron signos de malignidad.</font></font></p> <p><strong><font style="vertical-align: inherit;"><font style="vertical-align: inherit;">Conclusi&oacute;n:</font></font></strong><font style="vertical-align: inherit;"><font style="vertical-align: inherit;"> En la actualidad, s&oacute;lo se han descrito dos casos de sialadenoma papil&iacute;fero pulmonar en la literatura. Este informe de caso representa el primer caso de sialadenoma papil&iacute;fero pulmonar en Alemania y Europa occidental. El comportamiento biol&oacute;gico de este tumor a&uacute;n se desconoce.</font></font></p> </div> </div> </div> <div class="border-bottom-1 py-2"> <div class="d-flex w-100 justify-content-between mb-1"> <span class="align-self-center"> Art铆culo de investigaci贸n </span> </div> <h3 class="mb-2 font-size-4"><a href="https://spanish.hilarispublisher.com/abstract/exposure-to-interferon-gamma-decreases-levels-and-activity-of-key-cell-cycle-proteins-resulting-in-severe-growth-arrest--38500.html" title="La exposici&oacute;n al interfer&oacute;n &gamma; disminuye los niveles y la actividad de prote&iacute;nas clave del ciclo celular, lo que provoca una detenci&oacute;n grave del crecimiento de la l&iacute;nea celular humana no transformada, WISH ">La exposici&oacute;n al interfer&oacute;n &gamma; disminuye los niveles y la actividad de prote&iacute;nas clave del ciclo celular, lo que provoca una detenci&oacute;n grave del crecimiento de la l&iacute;nea celular humana no transformada, WISH </a></h3> <p class="mb-2 font-size-3 text-muted"> <i class="fas fa-user"></i> Surabhi Vashistha y Parthasarathi Ajitkumar </p> <div class="row justify-content-between align-items-center"> <div class="col pl-0"> <a class="btn btn-link" data-toggle="collapse" href="#collapseAbstract117168" role="button" aria-expanded="false" aria-controls="collapseAbstract"> Abstracto </a> </div> <div class="col-sm-auto"> <nav class="nav a-mx-2"> <a href="https://spanish.hilarispublisher.com/abstract/exposure-to-interferon-gamma-decreases-levels-and-activity-of-key-cell-cycle-proteins-resulting-in-severe-growth-arrest--38500.html" title="haga clic aqu铆" class="card-link border-bottom-2 yellow-900 border-yellow-900"><i class="fas fa-file-alt fa-lg"></i> Abstracto</a> </nav> </div> </div> <div class="collapse" id="collapseAbstract117168"> <div class="card card-body p-2 bg-light"><p><font style="vertical-align: inherit;"><font style="vertical-align: inherit;">El interfer&oacute;n &alpha; (IFN&alpha;), un potente inhibidor de la proliferaci&oacute;n, inductor de la apoptosis y modulador inmunitario de las c&eacute;lulas de los mam&iacute;feros, se ha utilizado como agente anticancer&iacute;geno en la terapia contra el c&aacute;ncer. Se han dilucidado varios mecanismos moleculares, que dependen de las diferencias en el linaje de las c&eacute;lulas diana transformadas, para la inhibici&oacute;n del crecimiento o la apoptosis de las c&eacute;lulas cancerosas diana por el IFN&alpha;. Sin embargo, su mecanismo de acci&oacute;n sobre las c&eacute;lulas normales debe entenderse desde el punto de vista de: (i) el efecto del IFN&alpha; sobre la l&iacute;nea celular no transformada y (ii) el efecto secundario de la terapia con interfer&oacute;n sobre las c&eacute;lulas normales en pacientes con c&aacute;ncer. Utilizando la l&iacute;nea celular no transformada, la l&iacute;nea celular epitelial fetal humana (WISH), nuestros estudios anteriores hab&iacute;an demostrado que el IFN&alpha; detiene las c&eacute;lulas en un punto anterior al paso de activaci&oacute;n de la quinasa dependiente de ciclina 2 (CDK2) en la fase G1 del ciclo celular. En el presente estudio, identificamos una reducci&oacute;n significativa en los niveles y/o la actividad de ciclina E-CDK2, fosfatasa CDC25A, ciclina H, ciclina E, ciclina D, p21 y p27. La disminuci&oacute;n dr&aacute;stica en los niveles y/o la actividad de ciclina E y/o del complejo ciclina E-CDK2 podr&iacute;a haber causado el arresto del crecimiento de las c&eacute;lulas WISH por IFN&beta;.</font></font></p> </div> </div> </div> <div class="border-bottom-1 py-2"> <div class="d-flex w-100 justify-content-between mb-1"> <span class="align-self-center"> Art铆culo de investigaci贸n </span> </div> <h3 class="mb-2 font-size-4"><a href="https://spanish.hilarispublisher.com/abstract/treatment-couch-modeling-in-the-treatment-planning-system-eclipse-38499.html" title="Modelado de camillas de tratamiento en el sistema de planificaci&oacute;n de tratamientos Eclipse ">Modelado de camillas de tratamiento en el sistema de planificaci&oacute;n de tratamientos Eclipse </a></h3> <p class="mb-2 font-size-3 text-muted"> <i class="fas fa-user"></i> Daniela Wagner y Hilke Vorwerk </p> <div class="row justify-content-between align-items-center"> <div class="col pl-0"> <a class="btn btn-link" data-toggle="collapse" href="#collapseAbstract117167" role="button" aria-expanded="false" aria-controls="collapseAbstract"> Abstracto </a> </div> <div class="col-sm-auto"> <nav class="nav a-mx-2"> <a href="https://spanish.hilarispublisher.com/abstract/treatment-couch-modeling-in-the-treatment-planning-system-eclipse-38499.html" title="haga clic aqu铆" class="card-link border-bottom-2 yellow-900 border-yellow-900"><i class="fas fa-file-alt fa-lg"></i> Abstracto</a> </nav> </div> </div> <div class="collapse" id="collapseAbstract117167"> <div class="card card-body p-2 bg-light"><p><font style="vertical-align: inherit;"><font style="vertical-align: inherit;">Objetivo: Anteriormente, en los sistemas de planificaci&oacute;n de tratamiento (TPS), se esperaba que la camilla de tratamiento estuviera hecha de material equivalente al aire debido al material utilizado (carbono). Algunos estudios ya han demostrado que la camilla de tratamiento no se puede descuidar durante la planificaci&oacute;n del tratamiento. Hoy en d&iacute;a, el fabricante de TPS implement&oacute; la viabilidad de insertar estructuras de camilla de tratamiento. Este estudio tuvo como objetivo encontrar el modelado correcto de los par&aacute;metros de la camilla de tratamiento en el TPS Eclipse. M&eacute;todo: La camilla de tratamiento Varian Exact consta de una placa de carbono (longitud de 2,5 cm) y dos rieles m&oacute;viles (longitud de 8,5 cm) debajo. La camilla de tratamiento se puede modelar en TPS cambiando las unidades de campo Hounsfield (HU) para cada parte de la camilla de tratamiento. Para energ&iacute;as de fotones bajas y altas, la atenuaci&oacute;n de la camilla de tratamiento se midi&oacute; en un Clinac 2300 C/D y en el TPS se determin&oacute; la atenuaci&oacute;n del modelo de camilla de tratamiento para diferentes conjuntos de valores de HU. Las atenuaciones medidas y calculadas se compararon entre s&iacute;. Resultados: Se encontr&oacute; una aberraci&oacute;n m&iacute;nima entre la atenuaci&oacute;n calculada y medida de la camilla de tratamiento para los valores HU de -750 HU para la placa de carbono, -995 HU para el relleno de la placa de carbono y 225 HU para los rieles. Adem&aacute;s, se encontr&oacute; que la atenuaci&oacute;n depende del &aacute;ngulo del p&oacute;rtico. Como se esperaba, la atenuaci&oacute;n m&aacute;s alta se encontr&oacute; en la regi&oacute;n de los rieles debajo de la camilla de tratamiento. Conclusi&oacute;n: Para la camilla de tratamiento Varian Exact, los valores HU se deben ajustar a -750 HU para la placa de carbono, -995 HU para el relleno de la placa de carbono y 225 HU para los rieles. El mismo conjunto de HU se puede utilizar para energ&iacute;as de fotones altas y bajas. Con el conjunto correcto de valores HU, la camilla de tratamiento se modela correctamente en el TPS Eclipse.</font></font></p> </div> </div> </div> <div class="border-bottom-1 py-2"> <div class="d-flex w-100 justify-content-between mb-1"> <span class="align-self-center"> Art铆culo de investigaci贸n </span> </div> <h3 class="mb-2 font-size-4"><a href="https://spanish.hilarispublisher.com/abstract/docosahexaenoic-acid-dha-induces-p53dependent-growth-inhibition-in-transformed-colon-and-lung-cell-lines-expressing-wild-38497.html" title="El &aacute;cido docosahexaenoico (DHA) induce la inhibici&oacute;n del crecimiento dependiente de P53 en l&iacute;neas celulares transformadas de colon y pulm&oacute;n que expresan P53 de tipo salvaje ">El &aacute;cido docosahexaenoico (DHA) induce la inhibici&oacute;n del crecimiento dependiente de P53 en l&iacute;neas celulares transformadas de colon y pulm&oacute;n que expresan P53 de tipo salvaje </a></h3> <p class="mb-2 font-size-3 text-muted"> <i class="fas fa-user"></i> Keith D. Kikawa, Noah T, Ahwah SM y Pardini RS </p> <div class="row justify-content-between align-items-center"> <div class="col pl-0"> <a class="btn btn-link" data-toggle="collapse" href="#collapseAbstract117166" role="button" aria-expanded="false" aria-controls="collapseAbstract"> Abstracto </a> </div> <div class="col-sm-auto"> <nav class="nav a-mx-2"> <a href="https://spanish.hilarispublisher.com/abstract/docosahexaenoic-acid-dha-induces-p53dependent-growth-inhibition-in-transformed-colon-and-lung-cell-lines-expressing-wild-38497.html" title="haga clic aqu铆" class="card-link border-bottom-2 yellow-900 border-yellow-900"><i class="fas fa-file-alt fa-lg"></i> Abstracto</a> </nav> </div> </div> <div class="collapse" id="collapseAbstract117166"> <div class="card card-body p-2 bg-light"><p><font style="vertical-align: inherit;"><font style="vertical-align: inherit;">La suplementaci&oacute;n con &aacute;cidos grasos poliinsaturados n-3, tanto en estudios in vivo con la dieta como en modelos de cultivo de tejidos in vitro, tiene efectos antiproliferativos en las c&eacute;lulas tumorales. En el presente estudio, se examina el papel de la inhibici&oacute;n del crecimiento dependiente de p53 por el &aacute;cido docosahexaenoico (DHA), un &aacute;cido graso poliinsaturado n-3. Trabajos previos han establecido que el DHA es capaz de tener efectos inhibidores del crecimiento independientemente del estado mutacional de p53 en carcinomas de colon, sin embargo, uno de los mismos estudios mostr&oacute; un aumento en el n&uacute;mero de c&eacute;lulas apopt&oacute;ticas (medido por Annexin V-FITC) solo en las c&eacute;lulas tratadas con DHA del carcinoma de colon con p53 de tipo salvaje. Para determinar el papel potencial de p53 en la inhibici&oacute;n del crecimiento observada con el tratamiento con DHA de los carcinomas de colon humanos COLO-205 (p53 de tipo salvaje) y WiDr (p53 mutante, His 237) y los adenocarcinomas de pulm&oacute;n humanos A549 (p53 de tipo salvaje) y H441 (p53 mutante, cod&oacute;n 158), se emplearon in vitro siRNA espec&iacute;ficos de p53 y un inhibidor qu&iacute;mico de p53, pifitrina-&alpha;. Se observaron aumentos significativos en el n&uacute;mero de c&eacute;lulas tratadas con DHA mediante la adici&oacute;n de siRNA de p53 o pifitrina-&alpha; solo en las l&iacute;neas celulares COLO-205 y A549 que expresaban p53 de tipo salvaje, y estos se correlacionaron con una reducci&oacute;n en el porcentaje de c&eacute;lulas apopt&oacute;ticas y necr&oacute;ticas. Estos datos confirman un papel para la inhibici&oacute;n del crecimiento dependiente de p53 con el tratamiento con DHA.</font></font></p> </div> </div> </div> </div> <div class="col-12 col-sm-3"> <!--==========relevant topics==================--> <div class="mb-3"> <h4>Aspectos destacados de la revista</h4> <nav class="nav flex-column scrollbar a-pl-0" style="max-height:50vh;"> <a href="https://spanish.hilarispublisher.com/scholarly/advances-in-alternative-lung-cancer-treatment-journals-articles-ppts-list-2298.html" class="nav-link" title="Avances en el tratamiento alternativo del c&aacute;ncer de pulm&oacute;n" title="haga clic aqu铆"><i class="far fa-hand-point-right"></i> Avances en el tratamiento alternativo del c&aacute;ncer de pulm&oacute;n</a> <a href="https://spanish.hilarispublisher.com/scholarly/esophageal-cancer-journals-articles-ppts-list-2295.html" class="nav-link" title="C&aacute;ncer de es&oacute;fago" title="haga clic aqu铆"><i class="far fa-hand-point-right"></i> 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