Plenary Keynotes | Discovery On Target

<!DOCTYPE html> <html lang="en"> <head> <meta http-equiv="X-UA-Compatible" content="IE=edge,chrome=1" /> <meta charset="utf-8" /><script type="text/html" id="sf-tracking-consent-manager"> <style> /*Consent Form*/ #tracking-consent-dialog { padding: 15px; position: fixed; bottom: 0; right: 5px; width: 337px; border: 3px solid #1e82e0; border-radius: 5px 5px 0px 0px; background: rgba(255, 255, 255, .95); font-size: 16px; z-index: 999; } #tracking-consent-dialog-accept { background-color: #1e82e0; color: #fff; font-size: 16px; font-weight: 500; float: right; } .consent-close { font-weight: bold; float: right; padding: 2px 7px; right: 6px; top: 3px; cursor: pointer; font-size: 11px; position: absolute; background-color: #1e82e0; color: #fff; z-index: 999; border-radius: 50%; } @media (max-width: 767px) { #tracking-consent-dialog { width: 100%; font-size: 14px; } } </style> <div id="tracking-consent-dialog"> <div class="consent-close" onclick="TrackingConsentManager.updateUserConsent(true)">X</div> <strong>Cookie Policy</strong> <p>CII uses cookies to improve your website & conference experiences, including enhancing website navigation, personalized features & promotions, evaluating our services, and customizing content and ads based on your preferences as you browse or engage with us. By clicking "Continue" or continuing to use our site, you are agreeing to our and our partners use of cookies. See our <a href="https://www.cambridgeinnovationinstitute.com/Privacy-Policy/">Privacy Policy</a> for more information.</p> <button type="button" onclick="TrackingConsentManager.updateUserConsent(true)" id="tracking-consent-dialog-accept" class="btn btn-default">Continue</button> </div> </script><script type="text/javascript" src="/WebResource.axd?d=DzHrpQl5URXarFHAtrmzFrNeeCwCLwHK2gvGZ95fW9WnidZLXrfDlGTuxUr3l463ttkzDVh9D8Bug9pu7NHdr_V4jKJPpR5aBflu4f8Ts5edKoXW2sH8LcSZSfqlYNJ5LpoUn5WBE_fdKcz0yNVMxY3w_4XLcip6ESbZeM3DDdUqeeNFFCEiKQKGKqR186oo0&t=637922505220000000"> </script> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no" /> <script src="/ScriptResource.axd?d=okuX3IVIBwfJlfEQK32K3iZZtiInnD21Q3naS01thH9-fzUaksT1ZtMUjWfsR2IfFrdwuSgx30ngwb9MjfyLwf8qicr33ktg3mwcpW2o3dsDH8d3-t4otTq9qT-5mrFfzK1f5nCn185AY5nCZScdoqJ1WOdlA_-4T4B_v3AbufPsc2J5Jr9-kOiHGAB_hap-0&t=4e1c7b51" type="text/javascript"></script><script src="/ScriptResource.axd?d=EydukmxBmDstn7gSYzQESGX1Bc6SUabUViYB9LpdmFW6eZLmGFNo26FA-YqkH5f3QjtPWjAHxth32_ExmLGGY1zv6AdaQenYAqaM29qW1bTxx1r5T--aFytKsL9IQMjnWBhhM3Ox0iMnCMCJK5xrzQardvmrid9DGkma-HwbE57flKsxZSkIFbT-h8oEIp2m0&t=4e1c7b51" type="text/javascript"></script><link href="/ResourcePackages/Bootstrap/assets/dist/css/main.min.css" rel="stylesheet" type="text/css" /><link href="/css/global.css" rel="stylesheet" type="text/css" /><link href="/css/editor.css" rel="stylesheet" type="text/css" /> <link href="//fonts.googleapis.com/css?family=Roboto:500,400,700" rel="stylesheet" type="text/css"> <meta property="og:title" content="Plenary Keynotes | Discovery On Target | Sept 30 - Oct 3, 2024" /><meta property="og:description" content="Learn about big-picture perspectives, innovative technologies, and thought-provoking trends from luminaries in the field at the keynote speeches at Discovery On Target." /><meta property="og:url" content="https://www.discoveryontarget.com/plenary-keynotes" /><meta property="og:type" content="website" /><meta property="og:site_name" content="Discovery On Target" /><link href="/css/24/dot/style-dot.css" media="all" rel="stylesheet" type="text/css" /><style type="text/css" media="all">p.Header { color:#1a4276; } </style><script type="text/javascript"> (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-NKZ2R7R'); </script><script type="text/javascript"> var link = document.createElement('link'); link.id = 'dynamic-favicon'; link.rel = 'shortcut icon'; link.href = '/images/librariesprovider5/template-images/24/favicon.png'; document.head.appendChild(link); </script><meta name="Generator" content="Sitefinity 14.2.7900.0 DX" /><link rel="canonical" href="https://www.discoveryontarget.com/plenary-keynotes" /><script type="application/json" id="sf-insight-metadata"> {"contentMetadata":"{\"Id\":\"4cfdbcea-61db-4a38-a201-bbeb22ddaaf0\",\"ContentType\":\"Page\",\"Title\":\"Plenary Keynotes\",\"CanonicalTitle\":\"Plenary Keynotes\",\"CanonicalUrl\":\"https://www.discoveryontarget.com/plenary-keynotes\",\"CreatedOn\":\"2018-02-06T22:14:44Z\",\"ModifiedOn\":\"2024-04-23T21:18:56Z\",\"SiteName\":\"Discovery On Target\",\"PageId\":\"4cfdbcea-61db-4a38-a201-bbeb22ddaaf0\"}","videosMetadata":"[]"} </script><script type="application/json" id="sf-insight-settings"> {"apiServerUrl":"https://api.insight.sitefinity.com/","apiKey":"62dc77b5-9fbc-74c6-8f79-d05463f0565e","applicationName":"CII_DEC","trackingCookieDomain":"","keepDecTrackingCookieOnTrackingConsentRejection":false,"slidingExpirationForTrackingCookie":false,"maxAgeForTrackingCookieInDays":365,"trackYouTubeVideos":true,"strategy":"Persist|False","docsHrefTestExpressions":[".*\\/docs\\/.+\\.{1}.+((\\?|\\\u0026)sfvrsn=.+){1}$",".+((\\?|\\\u0026)sf_dm_key=.+){1}$"]} </script><script type="text/javascript" src="/WebResource.axd?d=HtQyXelCu6mzSPcVcvK_BrDGcMZ2eaAwTGCTL_5l9xvo0iV9h2YYkvXanQ1uf0LidxbxWd8AzxNrppPmU7C9KnzDV98eKbg88D2zgKyY_GVq-IK4cwpq3ApmVVQHZ20G6_cSyVvbsc3d7cEOVVpoZalFAGFOo2fFcbG9u0riPX3ha1PNvfZCNU2C8dj5lXB2aevtM9BprQUEvuhENe--svD7i9F-8WutvDj5rAfLCkI1&t=637922505220000000"> </script><script src="https://cdn.insight.sitefinity.com/sdk/sitefinity-insight-client.min.3.1.7.js" async="async"> </script><link href="/Telerik.Web.UI.WebResource.axd?d=PMrIT5dOWaVYIcpFWUE4nCGcRFDqtHj8a0dT9N7jtPAWgyp5t5fff0pvXeFargWg3kuRljuyyjKW8grLvrafOr9X0kIEdj24q9AbiZ0prs7qITvLoGQxdqYfpMFPSD250&t=638482241021526486&compress=0&_TSM_CombinedScripts_=%3b%3bTelerik.Sitefinity.Resources%2c+Version%3d14.2.7900.0%2c+Culture%3dneutral%2c+PublicKeyToken%3db28c218413bdf563%3aen%3aec7772cc-ee32-478e-8437-4242283bb12f%3a7a90d6a" type="text/css" rel="stylesheet" /><title> Plenary Keynotes | Discovery On Target | Sept 30 - Oct 3, 2024 </title><meta name="description" content="Learn about big-picture perspectives, innovative technologies, and thought-provoking trends from luminaries in the field at the keynote speeches at Discovery On Target." /></head> <body><form method="post" action="./plenary-keynotes" id="aspnetForm"> <div class="aspNetHidden"> <input type="hidden" name="ctl04_TSM" id="ctl04_TSM" value="" /> <input type="hidden" name="ctl05_TSSM" id="ctl05_TSSM" value="" /> <input type="hidden" name="__EVENTTARGET" id="__EVENTTARGET" value="" /> <input type="hidden" name="__EVENTARGUMENT" id="__EVENTARGUMENT" value="" /> <input type="hidden" name="__VIEWSTATE" id="__VIEWSTATE" value="QRxOdtSXURGAPLiRmU+INBVV2D6UTkoa9IPJBIWusuMs6WE1thkBcXFNLOqiIx7kpuUccNYpJz7Oekm1QmmSUNO+WBc5MRwQBp4OpXoDQpM=" /> </div> <script type="text/javascript"> //<![CDATA[ var theForm = document.forms['aspnetForm']; if (!theForm) { theForm = document.aspnetForm; } function __doPostBack(eventTarget, eventArgument) { if (!theForm.onsubmit || (theForm.onsubmit() != false)) { theForm.__EVENTTARGET.value = eventTarget; theForm.__EVENTARGUMENT.value = eventArgument; theForm.submit(); } } //]]> </script> <script src="/WebResource.axd?d=pynGkmcFUV13He1Qd6_TZA_YQJD9xSUnUi70uTXUUGkw9zf_LlVkiouvQJnBXeCn1svgT4yxk9LfN7iuqrWtXg2&t=638459680569584809" type="text/javascript"></script> <script type="text/javascript"> //<![CDATA[ var __cultureInfo = {"name":"en","numberFormat":{"CurrencyDecimalDigits":2,"CurrencyDecimalSeparator":".","IsReadOnly":true,"CurrencyGroupSizes":[3],"NumberGroupSizes":[3],"PercentGroupSizes":[3],"CurrencyGroupSeparator":",","CurrencySymbol":"$","NaNSymbol":"NaN","CurrencyNegativePattern":0,"NumberNegativePattern":1,"PercentPositivePattern":1,"PercentNegativePattern":1,"NegativeInfinitySymbol":"-∞","NegativeSign":"-","NumberDecimalDigits":2,"NumberDecimalSeparator":".","NumberGroupSeparator":",","CurrencyPositivePattern":0,"PositiveInfinitySymbol":"∞","PositiveSign":"+","PercentDecimalDigits":2,"PercentDecimalSeparator":".","PercentGroupSeparator":",","PercentSymbol":"%","PerMilleSymbol":"‰","NativeDigits":["0","1","2","3","4","5","6","7","8","9"],"DigitSubstitution":1},"dateTimeFormat":{"AMDesignator":"AM","Calendar":{"MinSupportedDateTime":"\/Date(-62135578800000)\/","MaxSupportedDateTime":"\/Date(253402300799999)\/","AlgorithmType":1,"CalendarType":1,"Eras":[1],"TwoDigitYearMax":2029,"IsReadOnly":true},"DateSeparator":"/","FirstDayOfWeek":0,"CalendarWeekRule":0,"FullDateTimePattern":"dddd, MMMM d, yyyy h:mm:ss tt","LongDatePattern":"dddd, MMMM d, yyyy","LongTimePattern":"h:mm:ss tt","MonthDayPattern":"MMMM d","PMDesignator":"PM","RFC1123Pattern":"ddd, dd MMM yyyy HH\u0027:\u0027mm\u0027:\u0027ss \u0027GMT\u0027","ShortDatePattern":"M/d/yyyy","ShortTimePattern":"h:mm tt","SortableDateTimePattern":"yyyy\u0027-\u0027MM\u0027-\u0027dd\u0027T\u0027HH\u0027:\u0027mm\u0027:\u0027ss","TimeSeparator":":","UniversalSortableDateTimePattern":"yyyy\u0027-\u0027MM\u0027-\u0027dd HH\u0027:\u0027mm\u0027:\u0027ss\u0027Z\u0027","YearMonthPattern":"MMMM yyyy","AbbreviatedDayNames":["Sun","Mon","Tue","Wed","Thu","Fri","Sat"],"ShortestDayNames":["Su","Mo","Tu","We","Th","Fr","Sa"],"DayNames":["Sunday","Monday","Tuesday","Wednesday","Thursday","Friday","Saturday"],"AbbreviatedMonthNames":["Jan","Feb","Mar","Apr","May","Jun","Jul","Aug","Sep","Oct","Nov","Dec",""],"MonthNames":["January","February","March","April","May","June","July","August","September","October","November","December",""],"IsReadOnly":true,"NativeCalendarName":"Gregorian Calendar","AbbreviatedMonthGenitiveNames":["Jan","Feb","Mar","Apr","May","Jun","Jul","Aug","Sep","Oct","Nov","Dec",""],"MonthGenitiveNames":["January","February","March","April","May","June","July","August","September","October","November","December",""]},"eras":[1,"A.D.",null,0]};//]]> </script> <script src="/Telerik.Web.UI.WebResource.axd?_TSM_HiddenField_=ctl04_TSM&compress=0&_TSM_CombinedScripts_=%3b%3bSystem.Web.Extensions%2c+Version%3d4.0.0.0%2c+Culture%3dneutral%2c+PublicKeyToken%3d31bf3856ad364e35%3aen%3a18f1b484-bbc5-4e2e-8ca4-477603537f34%3aea597d4b%3ab25378d2" type="text/javascript"></script> <script src="/ScriptResource.axd?d=oBrf1f-DLFBYf_XnAiQIerYbp6DB1yP-XX6e2f1MfVZVh0-b8UJuYKCCtCgeTZdgs__r0fZWEGLHIbAdafwt8M9e685ZdEjP_79w8Op8pqlhtK8RVD9yvuuHQYso7wAeipQsr1KNKlxF-82gFsHvkROGzjmcQ59FFLTFjwumrh-7zfhoHiIXFsqfCwU3VcIw0&t=4e1c7b51" type="text/javascript"></script> <script src="/Telerik.Web.UI.WebResource.axd?_TSM_HiddenField_=ctl04_TSM&compress=0&_TSM_CombinedScripts_=%3b%3bTelerik.Sitefinity.Resources%3aen%3aec7772cc-ee32-478e-8437-4242283bb12f%3ab162b7a1" type="text/javascript"></script> <script src="/Frontend-Assembly/Telerik.Sitefinity.Frontend/Mvc/Scripts/Bootstrap/js/bootstrap.min.js?package=Bootstrap&v=MTQuMi43OTAwLjA%3d" type="text/javascript"></script> <script src="/js/sgs/menu-wsub.js" type="text/javascript"></script> <div class="aspNetHidden"> <input type="hidden" name="__VIEWSTATEGENERATOR" id="__VIEWSTATEGENERATOR" value="9CB23F91" /> </div><script type="text/javascript"> //<![CDATA[ Sys.WebForms.PageRequestManager._initialize('ctl00$ctl04', 'aspnetForm', [], [], [], 90, 'ctl00'); //]]> </script> <input type="hidden" name="ctl00$ctl04" id="ctl04" /> <script type="text/javascript"> //<![CDATA[ Sys.Application.setServerId("ctl04", "ctl00$ctl04"); Sys.Application._enableHistoryInScriptManager(); //]]> </script> <iframe id="__historyFrame" src="/ScriptResource.axd?d=9VrkpNgmpoekbVGVBA9L5EcaHQ9ZQsCardwf9VwyR6pNlfBkmCO-rM-wO5z-xKWN1nX83SwNnbvBg_M1dAsiQNti6uF14Wy-kZOS_-HmU89GRXYLvqu5oQgJQaG5egA_WGZpwgunmKI44Wz1Pno4_g2" style="display:none;"> </iframe> <div> <div class="navbar navbar-default navbar-fixed-top"> <a class="navbar-brand large" href="/"></a> <div class="navbar-header"> <button type="button" class="navbar-toggle" data-toggle="collapse" data-target=".navbar-collapse"> <span class="icon-bar"></span> <span class="icon-bar"></span> <span class="icon-bar"></span> </button> </div> <div class="collapse navbar-collapse" id="bs-example-navbar-collapse-1"> <ul class="nav navbar-nav large-nav" role="menu"> <li class="dropdown"> <a href="#" class="dropdown-toggle" role="button"> Agenda </a> <ul role="menu" class="dropdown-menu"> <li class=""> <a href="/get-involved" target="_self">Get Involved</a> </li> <li class=""> <a href="/programs" target="_self">Programs</a> </li> <li class=""> <a href="/Interactive-Discussions" target="_self">In-Person Breakouts</a> </li> <li class=""> <a href="/short-courses" target="_self">Short Courses</a> </li> <li class="active"> <a href="/plenary-keynotes" target="_self">Plenary Keynotes</a> </li> <li class=""> <a href="/speaker-biographies" target="_self">Speaker Biographies</a> </li> <li class=""> <a href="/training-seminars" target="_self">Training Seminars</a> </li> <li class=""> <a href="/attendees" target="_self">Attendees</a> </li> <li class=""> <a href="/agenda/search-the-agenda" target="_self">Search the Agenda</a> </li> <li class=""> <a href="/Networking" target="_self">Networking</a> </li> <li class=""> <a href="/dot/archives" target="_self">Archives</a> </li> </ul> </li> <li class="dropdown"> <a href="#" class="dropdown-toggle" role="button"> Sponsor/Exhibitor </a> <ul role="menu" class="dropdown-menu"> <li class=""> <a href="/sponsor" target="_self">Attendee Demographics + Event Features</a> </li> <li class=""> <a href="/sponsorship-opportunities" target="_self">Sponsorship Opportunities</a> </li> <li class=""> <a href="/sponsors" target="_self">Current Sponsors</a> </li> <li class=""> <a href="https://www.intheorious.com/chi/pub/dot2024b_pub/" target="_blank">Current Exhibitors - Floorplan</a> </li> <li class=""> <a href="https://www.intheorious.com/chi/pub/dot2025b_pub/" target="_blank">Re-sign Floorplan</a> </li> <li class=""> <a href="/exhibit-services-schedule" target="_self">Exhibit Services Schedule</a> </li> <li class=""> <a href="/exhibitor-prospectus-download-form" target="_self">Exhibitor Prospectus</a> </li> <li class=""> <a href="http://www.healthtech.com/Lead-Gen/" target="_blank">Lead Generation Opportunities</a> </li> <li class=""> <a href="/faq" target="_self">FAQs</a> </li> <li class=""> <a href="https://spex-cii.com/" target="_blank">Sponsor & Exhibitor Portal</a> </li> <li class=""> <a href="/best-of-show-awards" target="_self">Best of Show Awards</a> </li> </ul> </li> <li class="dropdown"> <a href="#" class="dropdown-toggle" role="button"> Media </a> <ul role="menu" class="dropdown-menu"> <li class=""> <a href="/media-partners" target="_self">Media Partners</a> </li> <li class=""> <a href="/downloads" target="_self">Downloads</a> </li> <li class=""> <a href="/media-gallery" target="_self">Media Gallery</a> </li> </ul> </li> <li class=""><a href="/travel" target="_self">Travel</a></li> <li class="dropdown"> <a href="#" class="dropdown-toggle" role="button"> Posters </a> <ul role="menu" class="dropdown-menu"> <li class=""> <a href="/posters" target="_self">Poster Information</a> </li> <li class=""> <a href="/poster-titles" target="_self">Poster Titles</a> </li> </ul> </li> <li class="dropdown"> <a href="#" class="dropdown-toggle" role="button"> Register </a> <ul role="menu" class="dropdown-menu"> <li class=""> <a href="https://register.cambridgeinnovationinstitute.com/reg/dot" target="_self">Individual Pricing</a> </li> <li class=""> <a href="https://register.cambridgeinnovationinstitute.com/reg/dot/group" target="_self">Group Pricing</a> </li> <li class=""> <a href="https://register.cambridgeinnovationinstitute.com/reg/dot/ondemand" target="_self">On Demand Pricing</a> </li> </ul> </li> </ul> </div> </div> </div> <div > <div class="sf-Long-text" > <div class="mobile-header hidden-sm hidden-md hidden-lg"><a href="/"><img class="imageResize" src="/images/librariesprovider5/template-images/24/header-mob.png?sfvrsn=30e988b0_3" alt="Discovery on Target 2024" /></a> </div></div> </div> <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-NKZ2R7R"height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript> <div class="main-content"> <div id="cph1" class="container internal"> <div class="row"> <div class="row" data-sf-element="Row"> <div class="col-sm-9"> <div id="Contentplaceholder1_TDA1EA21B001_Col00" class="sf_colsIn pad-lr" data-sf-element="Column 1" data-placeholder-label="Column 1"> <div > <div class="sf-Long-text" ><h1 class="page-title">Plenary Keynote Program</h1><p>Join colleagues from around the world for the Discovery on Target Plenary Keynote Program. Bridging both halves of the event, it's the only time our whole community of drug discovery professionals assembles together to learn about big-picture perspectives, innovative technologies, and thought-provoking trends from luminaries in the field.</p><p>This year’s program runs on Wednesday, October 2 from 10:50 am - 12:25 pm EDT.</p><p class="Date">WEDNESDAY, OCTOBER 2</p><p><b></b><b>10:55 am Discovery of Transformative Rx to Treat Obesity and Related Diseases</b><br /><i><img src="/images/librariesprovider5/agenda/24/richard-dimarchi.jpg?sfvrsn=f69212f1_1" alt="Richard Dimarchi" class="SpeakerFl" />Richard DiMarchi, PhD, Distinguished Professor of Chemistry and Chair, Biomolecular Sciences, Indiana University; former Executive, Lilly and Novo Research Labs</i><br />Obesity represents a medicinal challenge that warrants broad molecular diversity. We have pioneered the recruitment of endogenous hormones and physiological mechanisms optimized for pharmacological purposes to address it. The discovery of single-molecule, multi-mechanism incretins enables breakthrough efficacy in lowering body weight. The integrated pharmacology of these peptides, with endocrine proteins and nuclear hormones, is providing a library of drug candidates that promises even greater clinical outcomes and therapy for associated diseases that have historically proven as intractable to treat as obesity once constituted.<br /><br />Professor DiMarchi is a member of the National Academy of Medicine and the National Inventors Hall of Fame. He is a former Group Vice President at Lilly and later Novo. His contributions pertain to the discovery and development of Humalog®, rGlucagon®, Forteo®, and Evista®. His research includes discovery of peptides transforming the treatment of diabetes and obesity. He is co-inventor on >100 U.S. patents and co-author to >250 scientific publications. He was identified as a top-five translation researcher by <i>Nature Biotechnology</i>. Since 2003, he has co-founded eight successful biotech companies.</p><br /><p><b>11:40 am Fragment-Based Drug Discovery for Elusive Cancer Targets</b><i><br clear="all" /><img src="/images/librariesprovider5/agenda/24/stephen-fesik.jpg?sfvrsn=5e44d700_1" class="SpeakerFl" alt="Stephen Fesik" />Stephen W. Fesik, PhD, Professor of Biochemistry, Pharmacology & Chemistry; Orrin H. Ingram II Chair in Cancer Research, Vanderbilt University</i><br />The most highly validated cancer targets (KRAS, MYC, and WNT) affecting the majority of cancers are thought to be impossible to drug. Using fragment-based methods that I pioneered over 25 years ago, we have discovered mutant selective and pan KRAS inhibitors, potent inhibitors of the MYC cofactor WDR5, and degraders of b-catenin in the WNT pathway. These novel inhibitors/degraders should have a tremendous impact on cancer treatment in the future.<br /><br />Stephen W. Fesik, PhD is the Orrin H. Ingram II Chair in Cancer Research and a Professor of Biochemistry, Pharmacology, and Chemistry at Vanderbilt University School of Medicine. He is also a member of the Vanderbilt Ingram Cancer Center (VICC), the Vanderbilt Institute of Chemical Biology (VICB), and the Center for Structural Biology (CSB). The focus of his research is on cancer drug discovery using fragment-based approaches and structure-based drug design. Prior to joining Vanderbilt in May 2009, Dr. Fesik was the Divisional Vice President of Cancer Research at Abbott (2000-2009) where he built a pipeline of compounds that are showing promising anti-cancer activities in early-stage clinical trials. In addition, while he was at Abbott, he developed several new NMR methods, determined the three-dimensional structures of several proteins and protein/ligand complexes, pioneered a fragment-based method for drug discovery called SAR by NMR, and applied this method to identify and optimize ligands for binding to many protein drug targets. Dr. Fesik has published more than 295 papers, trained 68 postdoctoral fellows, and has served as a member of the Editorial Boards of many scientific journals, scientific advisory boards, and the Keystone and Bruker Board of Directors. He has also obtained several awards, such as the Lifetime Achievement Award in Nuclear Magnetic Resonance from EAS (2003), the SBS Technology Innovation Award (2010), the NIH Director's Pioneer Award (2010), the AACR Award for Outstanding Achievement in Chemistry in Cancer Research (2012), and 2021 Chester Stock Award from Memorial Sloan Kettering Cancer Center.</p><br /><br clear="all " /></div> </div></div> </div> <div class="col-sm-3"> <div id="Contentplaceholder1_TDA1EA21B001_Col01" class="sf_colsIn pad-lr" data-sf-element="Column 2" data-placeholder-label="Column 2"><div class='sfContentBlock'> <br class="hidden-sm hidden-md hidden-lg" /><div class="social-icons"><a target="_blank" href="/docs/librariesprovider5/og/discovery-on-target_2024.ics?sfvrsn=5a8c1984_3&download=true" title="Outlook"><img src="/images/default-source/social/calendar-gray.png?sfvrsn=91696e36_6" title="Outlook" alt="Outlook" class="social-icon" /></a> <a href="http://www.youtube.com/user/CambridgeHealthtech" target="_blank" title="YouTube"><img src="/images/default-source/social/youtube-gray.png?sfvrsn=6bad7b8f_4" alt="YouTube" title="YouTube" class="social-icon" /></a>  <a href="https://www.linkedin.com/groups/1907365/" target="_blank" title="LinkedIn"><img src="/images/default-source/social/linkedin-gray.png?sfvrsn=ed70471e_4" alt="LinkedIn" title="LinkedIn" class="social-icon" /></a> <a href="https://twitter.com/BostonDOT" target="_blank" title="Twitter"><img src="/images/default-source/social/twitter-gray.png?sfvrsn=bac909e7_7" alt="Twitter" title="Twitter" class="social-icon" /></a> </div><div class="sidebar-hashtag"><b>#BostonDOT24</b></div><hr /> </div><div class='sfContentBlock'><div><a href="/2024-brochure-download-form"><img src="/images/librariesprovider5/sidebar/24/download-brochure-rc02b5d660-1d8c-42e1-a4ea-e13528301b96.png?sfvrsn=2a0a7dea_1" alt="2024 Final Agenda Download" class="imageResize" /></a> </div><div class="sidebar-item"><a href="https://register.cambridgeinnovationinstitute.com/reg/dot/ondemand"><img src="/images/librariesprovider5/sidebar/24/register-date-rc.png?sfvrsn=7fb81f80_10" class="imageResize" alt="Register Early for Maximum Savings" /></a> </div><div class="sidebar-item"><a href="/mailing-list"><img src="/images/librariesprovider5/sidebar/24/register-cta-rc.png?sfvrsn=264b415d_1" class="imageResize" alt="Stay up to Date on our 2023 Program" /></a> </div><div class="sidebar-item"><a href="/programs"><img src="/images/librariesprovider5/sidebar/24/2024-programs-rc.png?sfvrsn=d5cd6a4d_1" class="imageResize" alt="2024 Programs" /></a> </div><div class="sidebar-item"><a href="/docs/librariesprovider5/agendaa/24/dot24-recommended-courses.pdf?sfvrsn=120bdd93_1" target="_blank"><img src="/images/librariesprovider5/sidebar/24/dot-plan-your-week-rc.png?sfvrsn=ed974a24_1" class="imageResize" alt="Plan your Week" /></a> </div> <div class="sidebar-tracks"><p class="secondary-text flush-bottom sidebar-item">Conference Programs</p><hr class="sidebar-rule" /><p class="sidebar-date">September 30</p><a data-sf-ec-immutable="" href="/targeting-kinase">Strategies for Targeting Kinases</a> <a data-sf-ec-immutable="" href="/covalent-chemistries">Covalent Chemistries and Induced Proximity <span class="new">NEW</span></a> <a data-sf-ec-immutable="" href="/immune-modulation-strategies">Emerging Immune Modulation Strategies</a> <a data-sf-ec-immutable="" href="/biology-drug-discovery-therapy">Synthetic Biology for Drug Discovery and Therapy <span class="new">NEW</span></a> <hr class="sidebar-rule" /><p class="sidebar-date">October 1-2</p><a data-sf-ec-immutable="" href="/protacs-molecular-glues-part1">Degraders and Molecular Glues – Part 1</a> <a data-sf-ec-immutable="" href="/lead-generation-strategies">Lead Generation Strategies</a> <a data-sf-ec-immutable="" href="/small-molecules-cancer-targets">Small Molecules for Cancer Targets</a> <a data-sf-ec-immutable="" href="/membrane-proteins">Antibodies Against Membrane Protein Targets</a> <a data-sf-ec-immutable="" href="/rna-small-molecules">Small Molecules Targeting RNA</a> <a data-sf-ec-immutable="" href="/ai-ml-enabled-drug-discovery-part1">AI/ML-Enabled Drug Discovery – Part 1</a> <a data-sf-ec-immutable="" href="/translational-models">Physiologically Relevant Translational Models</a> <a href="/training-seminars#8A" data-sf-ec-immutable="">GPCR Pharmacodynamics: Kinetics, Allosterism, and Biased Agonism in Pharma Discovery <span class="new">NEW</span></a> <hr class="sidebar-rule" /><p class="sidebar-date">October 2-3</p><a data-sf-ec-immutable="" href="/protacs-molecular-glues-part2">Degraders and Molecular Glues – Part 2</a> <a data-sf-ec-immutable="" href="/target-identification-strategies">Target Identification Strategies</a> <a data-sf-ec-immutable="" href="/gpcr-drug-discovery">GPCR-Based Drug Discovery</a> <a data-sf-ec-immutable="" href="/cancer-antibodies">Cancer Antibodies</a> <a data-sf-ec-immutable="" href="/targeting-transcription-factors">Targeting Transcription Factors</a> <a data-sf-ec-immutable="" href="/ai-ml-enabled-drug-discovery-part2">AI/ML-Enabled Drug Discovery – Part 2</a> <a href="/training-seminars#7B" data-sf-ec-immutable="">Drug Exposure at the Target: The Role of ADME and Pharmacokinetics <span class="new">NEW</span></a> </div> </div></div> </div> </div> </div> </div> </div> <footer> <div > <div class="sf-Long-text" ><div class="footer"><div class="container"><div class="row"><div class="col-sm-3 col-xs-12"><div class="footer-small"><div class="footer-small-inner"><img alt="CHI | Cambridge HealthTech Institute" class="CII-footer" src="/UploadedImages/CHI-logo.png" data-sf-ec-immutable="" /><br /><p>250 First Avenue, Suite 300<br />Needham, MA 02494<br /><br />P: 781.972.5400<br />F: 781.972.5425 <br />E: <a href="mailto:chi@healthtech.com?cdtConferenceId=404272006.1663694140&cdtRollupId=404272006.1663694140" data-sf-ec-immutable="">chi@healthtech.com</a> </p><div class="row"><div class="col-sm-12 footer-social"><a href="https://twitter.com/CHI_Healthtech" data-sf-ec-immutable=""><img src="/images/default-source/social/twitter-gray.png?sfvrsn=bac909e7_7" alt="" class="footer-social-icons" /></a> <a href="https://www.linkedin.com/company/cambridge-healthtech-institute" data-sf-ec-immutable=""><img src="/images/default-source/social/linkedin-gray.png?sfvrsn=ed70471e_4" class="footer-social-icons" alt="" /></a> <a href="https://www.facebook.com/HealthtechConferences" data-sf-ec-immutable=""><img src="/images/default-source/social/facebook-gray.png?sfvrsn=35d4a48c_4" class="footer-social-icons" alt="" /></a> </div></div></div></div></div><div class="col-sm-4 footer-border hidden-xs"><div class="row"><div class="col-sm-12"><p>Life Science Portals</p></div><div class="col-sm-6"><p><a href="http://biologicaltherapeutics.cambridgeinnovationinstitute.com/home">Biological Therapeutic Products</a></p><p><a href="http://biomarkers.cambridgeinnovationinstitute.com/home">Biomarkers & Diagnostics</a></p><p><a href="http://biopharmastrategy.cambridgeinnovationinstitute.com/home">Biopharma Strategy</a></p><p><a href="https://bioprocessing.cambridgeinnovationinstitute.com/home">Bioprocess & Manufacturing</a></p><p><a href="http://chemistry.cambridgeinnovationinstitute.com/home">Chemistry</a></p><p><a href="http://clinicaltrials.cambridgeinnovationinstitute.com/home">Clinical Trials &<br data-sf-ec-immutable="" />Translational Medicine</a></p><p><a href="http://druganddevice.cambridgeinnovationinstitute.com/home">Drug & Device Safety</a></p></div><div class="col-sm-6"><p><a href="http://drugdevelopment.cambridgeinnovationinstitute.com/home">Drug Discovery & Development</a></p><p><a href="http://drugtargets.cambridgeinnovationinstitute.com/home">Drug Targets</a></p><p><a href="http://healthcare.cambridgeinnovationinstitute.com/home">Healthcare</a></p><p><a href="http://it.cambridgeinnovationinstitute.com/home">IT, AI, ML & Informatics</a></p><p><a href="http://techtools.cambridgeinnovationinstitute.com/home">Technology & Tools For<br data-sf-ec-immutable="" />Life Science</a></p><p><a href="http://therapeutics.cambridgeinnovationinstitute.com/home">Therapeutic Indications</a></p><p><a href="https://www.cambridgeinnovationinstitute.com/vip-series" data-sf-ec-immutable="">Venture, Innovation & Partnering</a></p></div></div></div><div class="col-sm-3 footer-border hidden-xs"><p>CHI Divisions</p><p><a href="https://www.healthtech.com/?cdtConferenceId=404272006.1663694140&cdtRollupId=404272006.1663694140" data-sf-ec-immutable="">Conferences</a></p><p><a href="https://www.insightpharmareports.com/" data-sf-ec-immutable="">Reports & Market Research</a></p><p><a href="https://www.barnettinternational.com/" data-sf-ec-immutable="">Barnett Educational Services</a></p><p><a href="https://www.healthtech.com/publishing" data-sf-ec-immutable="">News & Advertising</a></p><p><a href="https://proservices.healthtech.com/?cdtConferenceId=404272006.1663694140&cdtRollupId=404272006.1663694140" data-sf-ec-immutable="">Professional Services</a></p></div><div class="col-sm-2 footer-border hidden-xs"><p>Corporate Information</p><p><a href="https://www.cambridgeinnovationinstitute.com/" data-sf-ec-immutable="">Cambridge Innovation<br />Institute</a></p><p><a href="https://www.cambridgeinnovationinstitute.com/Executive-Team/" data-sf-ec-immutable="">Executive Team</a></p><p><a href="https://www.cambridgeinnovationinstitute.com/Testimonials/" data-sf-ec-immutable="">Testimonials</a></p><p><a href="https://www.cambridgeinnovationinstitute.com/mailing-list.html" data-sf-ec-immutable="">Mailing List</a></p><p><a href="https://www.cambridgeinnovationinstitute.com/Careers/" title="Careers" data-sf-ec-immutable="">Careers</a></p><hr /><p><a href="https://www.cambridgeinnovationinstitute.com/request-information" data-sf-ec-immutable="">Request Information</a></p><p><a href="https://www.cambridgeinnovationinstitute.com/Privacy-Policy/" data-sf-ec-immutable="">Privacy Policy</a></p></div></div></div></div></div> </div> </footer> <script type="text/javascript"> //<![CDATA[ window.__TsmHiddenField = $get('ctl04_TSM');;(function() { function loadHandler() { var hf = $get('ctl05_TSSM'); if (!hf._RSSM_init) { hf._RSSM_init = true; hf.value = ''; } hf.value += ';Telerik.Sitefinity.Resources, Version=14.2.7900.0, Culture=neutral, PublicKeyToken=b28c218413bdf563:en:ec7772cc-ee32-478e-8437-4242283bb12f:7a90d6a'; Sys.Application.remove_load(loadHandler); }; Sys.Application.add_load(loadHandler); })();//]]> </script> </form><script type="application/json" id="PersonalizationTracker"> {"IsPagePersonalizationTarget":false,"IsUrlPersonalizationTarget":false,"PageId":"4cfdbcea-61db-4a38-a201-bbeb22ddaaf0"} </script><script type="text/javascript" src="/WebResource.axd?d=Oiw5o8i74rDb2VpVaCaMSouKRnJ2rn_cgRr8eXgFzWmU6yVv8fmvjGNlDReMboLSikSmK5y_KsDt9j-18b7ZqBNiz0-92AjY43-6qMcq4O__3MjW1Pd6kS68TTYuxCxnF4HnqcusO3ivgfHZzR9usujs8YAzvYku29ledrs3mezPir5ikBP0Pxh4nDmiJEk2WgW0YVPdsdMlu69MVd6jI94nvC3-40pMaRxtm9HTV2I1&t=637922505260000000"> </script><script type="text/javascript" src="/js/toggle-V2.js"></script><script type="text/javascript" src="/bower_components/js-url/url.min.js"></script><script type="text/javascript" src="/js/TrackClicks.js"></script><script type="text/javascript" src="/js/CrossDomainClient.js"></script></body> </html>

CINXE.COM

Plenary Keynotes | Discovery On Target | Sept 30 - Oct 3, 2024