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class="hidden"></div> </div> <div class="grid-row grid-gap"> <div class="usa-layout-docs__main desktop:grid-col-fill"> <div id="block-main-breadcrumbs" class="block block-system block-system-breadcrumb-block"> <nav class="usa-breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="usa-sr-only">Breadcrumb</h2> <ol class="usa-breadcrumb__list"> <li class="usa-breadcrumb__list-item"> <a href="/" class="usa-breadcrumb__link"><span>Home</span></a> </li> <li class="usa-breadcrumb__list-item"> <a href="/" class="usa-breadcrumb__link"><span>New Horizons</span></a> </li> <li class="usa-breadcrumb__list-item"> <span>Cancer Research</span> </li> </ol> </nav> </div> <div id="block-pagetitle" class="block block-core block-page-title-block"> <section class="hero hero--topic"> <div class="hero__img" style="background-image: url(https://www.energy.gov/sites/default/files/2023-09/090623-ip-radium223_1.jpg)"></div> <div class="grid-container"> <div class="hero__title"> <h1> <span class="field field--string field--title">Cancer Research</span> </h1> </div> </div> </section> </div> <div id="block-main-page-content" class="block block-system block-system-main-block"> <article about="/topics/cancer-research"> <div> <div class="callout"> <div class="grid-row grid-gap"> <div class="tablet:grid-col-1 grid-col-12 icon-col"> <i class="fa-solid fa-bolt"></i> </div> <div class="tablet:grid-col-11 grid-col-12 description-col"> Through its user facilities and other scientific resources, DOE provides tools and knowledge to cancer researchers that are available nowhere else. From supercomputers to particle accelerators to isotope production facilities to nuclear physics expertise, DOE has helped build the foundational science underlying cancer research. </div> </div> </div> <section class="layout blade-section--boxed blade-section--fullwidth" > <div class="grid-container"> <div class="blade-color " > <div class="grid-row"> <div class="grid-col"> <div class="block block-layout-builder block-extra-field-blocknodetopiclinks"> </div> <div class="block block-layout-builder block-extra-field-blocknodetopiccontent-moderation-control"> </div> </div> </div> </div> </div> </section> <section class="layout blade-section--fullwidth blade-section--blue--dark blade-section blade-section--text--white" id="content-block"> <div class="blade-color " > <div class="grid-container"> <div class="grid-row"> <div class="grid-col"> <div class="block block-layout-builder block-inline-blocktemplate"> <div class="field field--entity_reference_revisions_entity_view field--field_paragraph_reference field field--name-field-paragraph-reference field--type-entity-reference-revisions field--label-hidden field__item"> <div class="paragraph paragraph--type--two-column-image-and-text paragraph--view-mode--default"> <div class="grid-row grid-gap"> <div class=" tablet:grid-col-4 tablet:order-first "> <p class="title-2xl force-fullwidth--tablet">The role of supercomputing, isotopes, accelerators, and nuclear physics in cancer research</p> </div> <div class=" tablet:grid-col-8 tablet:order-1"> <div class="field field--text_default field--field_card_text field field--name-field-card-text field--type-text-long field--label-hidden field__item"><p>DOE鈥檚 supercomputers, isotope research and production facilities, and accelerator facilities have been key players in many aspects of cancer research. In addition to supporting this important area of medical research, the projects have also advanced DOE鈥檚 own scientific resources. </p><p>Researchers apply for time on DOE鈥檚 supercomputers to carry out a variety of research that benefits the nation. Scientists have used high-performance computing facilities at DOE鈥檚 national laboratories to model new cancer treatments, extract information from cancer images and patient data, and simulate how tumors grow. Recently, DOE experts on the Exascale Computing Project collaborated closely with researchers at the National Cancer Institute (NCI). Together, the team came up with solutions to protect the privacy of medical data and combine different types of data into a coherent whole. As a result, the team has developed artificial intelligence applications that cancer researchers across the country can now use. </p><p>Particle accelerators built for today鈥檚 scientific research use technologies that are making cancer radiotherapy machines smaller and faster. Since the earliest treatments of cancer using X-rays, accelerators have been tasked with providing electrons, high-energy X-rays, protons, neutrons, pions, and light ions to target and destroy cancer cells. Working with DOE and industry, NCI has helped develop a range of next-generation treatment technologies. These technologies range from tiny endoscopically mounted accelerators for electronic brachytherapy (a type of radiation therapy) to barn-sized accelerators using superconducting magnets to direct light ions precisely at the tumor. </p><p>DOE and its predecessor organizations have been at the forefront of developing and producing unique isotopes for medical and basic science research for decades. Isotopes are different forms of the standard elements on the Periodic Table of the Elements. Certain radioisotopes (radioactive isotopes that decay) are extremely useful in medical research, imaging, and therapies. DOE has helped spur a renaissance in nuclear medicine. By providing rare and new isotopes, DOE has enabled doctors to use new treatments for metastasized cancers. DOE has also developed transformative technologies to reestablish stable isotope enrichment in the United States. In addition, it has led creative approaches for producing rare radioisotopes that are foundational to cancer imaging and therapy. </p><p>While research on protons and neutrons began at the accelerators and reactors of the DOE national laboratories to help us better understand the building blocks of the universe, this research has led to important tools now used in cancer diagnosis and therapies. Recent technologies that were developed for particle detectors have been adapted to identify tumors and monitor doses of radiation in patients. </p><p>DOE鈥檚 national laboratories have contributed to many other technologies and research results as well, including in protein folding and molecule production for chemotherapy drugs. </p></div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </section> <section class="layout blade-section--fullwidth blade-section--blue--dark blade-section blade-section--text--white" id="highlights"> <div class="blade-color " > <div class="grid-container"> <div class="grid-row"> <div class="grid-col"> <div class="block block-layout-builder block-inline-blocktemplate block-title--highlights"> <div class="paragraph-reference__heading-subheading-wrapper"><div class="paragraph-reference-heading-wrapper paragraph-reference-heading-wrapper--"><h2 class="block block-layout-builder block-inline-blocktemplate block-title--highlights"> Highlights </h2></div></div> <div class="field field--entity_reference_revisions_entity_view field--field_paragraph_reference field field--name-field-paragraph-reference field--type-entity-reference-revisions field--label-hidden field__item"> <div class="paragraph paragraph--type--collection paragraph--view-mode--default"> <div class="paragraph__column"> <ul class="collection--cover-img collection"><li class="collection-item"> <article about="/science/doe-explainsisotopes" typeof="schema:WebPage"> <div class="collection-item--type-page collection-item-wrapper"> <div class="collection-item__image"> <div class="field field--media_thumbnail field--field_alternative_thumbnail field field--name-field-alternative-thumbnail field--type-entity-reference field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/full_article_width/public/2024-07/doe-explains-isotopes.png?itok=r3vHOg_a" width="1350" height="643" alt="Hydrogen and its two naturally occurring isotopes, deuterium and tritium. All three have the same number of protons (labeled p+) but different numbers of neutrons (labeled n)." title="Hydrogen and its two naturally occurring isotopes, deuterium and tritium. All three have the same number of protons (labeled p+) but different numbers of neutrons (labeled n)." typeof="foaf:Image" /> </div> </div> <div class="collection-item__icon"> <div class="fontawesome-icon"> <i class="far fa-file" data-fa-transform="" data-fa-mask="" style=""></i> </div> </div> <div class="collection-item__title title-sm"> <a class="collection-item__link" href="/science/doe-explainsisotopes"> <span property="schema:name" class="field field--string field--title">DOE Explains...Isotopes</span> </a> </div> <div class="collection-item__summary"> <div class="field field--basic_string field--field_summary field field--name-field-summary field--type-string-long field--label-hidden field__item">DOE Explains...Isotopes</div> </div> <div class="collection-item__date p2"> April 1, 2024 </div> </div> </article> </li><li class="collection-item"> <article about="/articles/ending-cancer-we-know-it-cancer-moonshot-and-americas-national-labs" typeof="schema:Article"> <div class="collection-item--type-blog collection-item--type-article collection-item-wrapper"> <div class="collection-item__image"> <div class="field field--media_thumbnail field--field_alternative_thumbnail field field--name-field-alternative-thumbnail field--type-entity-reference field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/full_article_width/public/2023-03/rid%20of%20cancer%20thumbnail.jpg?itok=SVdVon6V" width="1350" height="868" alt="Geneticist Wellington Muchero leads the research team at ORNL that has linked the PAN protein domain to tumor growth in humans and plant-microbe interactions in plants." typeof="foaf:Image" /> </div> </div> <div class="collection-item__icon"> <div class="fontawesome-icon"> <i class="far fa-newspaper" data-fa-transform="" data-fa-mask="" style=""></i> </div> </div> <div class="collection-item__topics micro"> <ul> <li>Biotechnology</li> <li>Cancer Research</li> <li>National Labs</li> <li>Explore Biology at DOE (Biology)</li> <li>Genomics</li> </ul> </div> <div class="collection-item__title title-sm"> <a class="collection-item__link" href="/articles/ending-cancer-we-know-it-cancer-moonshot-and-americas-national-labs"> <span property="schema:name" class="field field--string field--title">Ending Cancer as We Know It: The Cancer Moonshot and America鈥檚 National Labs</span> </a> </div> <div class="collection-item__summary"> <div class="field field--basic_string field--field_summary field field--name-field-summary field--type-string-long field--label-hidden field__item">The President鈥檚 Cancer Moonshot aims to reduce the death rate from cancer by at least 50% over the next 25 years, and to significantly improve the lives of people, and their families, living with and surviving cancer.</div> </div> <div class="collection-item__date p2"> <time datetime="2023-03-01T15:13:54Z">March 1, 2023</time> </div> </div> </article> </li><li class="collection-item"> <article about="/science/ip/articles/new-understanding-astatines-chemical-properties-will-aid-targeted-alpha-therapy" typeof="schema:Article"> <div class="collection-item--type-bulletin collection-item--type-article collection-item-wrapper"> <div class="collection-item__image"> <div class="field field--media_thumbnail field--field_alternative_thumbnail field field--name-field-alternative-thumbnail field--type-entity-reference field--label-hidden field__item"> <img loading="lazy" src="/sites/default/files/styles/full_article_width/public/2024-05/053124-ip-astatine.jpg?itok=XAyhs7Qy" width="1350" height="899" alt="Student working in the Texas A&M University lab processing astatine-211." typeof="foaf:Image" /> </div> </div> <div class="collection-item__icon"> <div class="fontawesome-icon"> <i class="far fa-newspaper" data-fa-transform="" data-fa-mask="" style=""></i> </div> </div> <div class="collection-item__topics micro"> <ul> <li>Isotopes</li> <li>Biotechnology</li> <li>Cancer Research</li> <li>Nuclear Energy</li> <li>Next-Generation Energy Technologies</li> </ul> </div> <div class="collection-item__title title-sm"> <a class="collection-item__link" href="/science/ip/articles/new-understanding-astatines-chemical-properties-will-aid-targeted-alpha-therapy"> <span property="schema:name" class="field field--string field--title">New Understanding of Astatine鈥檚 Chemical Properties Will Aid Targeted Alpha Therapy for Cancer</span> </a> </div> <div class="collection-item__summary"> <div class="field field--basic_string field--field_summary field field--name-field-summary field--type-string-long field--label-hidden field__item">Researchers gain new insights into how the isotope astatine-211 interacts with resins commonly used to purify the isotope for therapeutic use.</div> </div> <div class="collection-item__date p2"> <time datetime="2024-05-31T19:35:09Z">May 31, 2024</time> </div> </div> </article> </li></ul> </div> </div> </div> </div> </div> </div> </div> </div> </section> <section class="layout blade-section--fullwidth blade-section--blue--dark blade-section blade-section--text--white" id="image-block"> <div class="blade-color " > <div class="grid-container"> <div class="grid-row"> <div class="grid-col"> <div class="block block-layout-builder block-inline-blocktemplate"> <div class="field field--entity_reference_revisions_entity_view field--field_paragraph_reference field field--name-field-paragraph-reference field--type-entity-reference-revisions field--label-hidden field__item"> <div class="paragraph paragraph--type--media paragraph--view-mode--default"> <div class="paragraph__column"> <div class="field field--entity_reference_entity_view field--field_media_embed field field--name-field-media-embed field--type-entity-reference field--label-hidden field__item"><div class="media-type-image"> <div class="field field--image field--field_media_image field field--name-field-media-image field--type-image field--label-hidden field__item"> <img src="/sites/default/files/styles/full_article_width/public/2024-11/cancer-research-homepage-2.jpg?itok=D2w9h8Zn" width="1350" height="900" alt="A woman looking into a window in a laboratory." loading="lazy" typeof="foaf:Image" /> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </section> <section class="layout blade-section--fullwidth blade-section--blue--dark blade-section blade-section--text--white" id="content-block"> <div class="blade-color " > <div class="grid-container"> <div class="grid-row"> <div class="grid-col"> <div class="block block-layout-builder block-inline-blocktemplate"> <div class="field field--entity_reference_revisions_entity_view field--field_paragraph_reference field field--name-field-paragraph-reference field--type-entity-reference-revisions field--label-hidden field__item"> <div class="paragraph paragraph--type--two-column-image-and-text paragraph--view-mode--default"> <div class="grid-row grid-gap"> <div class=" tablet:grid-col-6 tablet:order-first "> <img src="/sites/default/files/2024-11/cancer-research-homepage-3.jpg" alt="An image of an isotope in a small vile." class="width-full object-fit-cover radius-lg margin-top-3" /> </div> <div class=" tablet:grid-col-6 tablet:padding-left-15 tablet:order-1"> <p class="title-2xl">Advances in cancer research enabled by DOE</p> <div class="field field--text_default field--field_card_text field field--name-field-card-text field--type-text-long field--label-hidden field__item"><p>DOE-supported tools and resources have enabled breakthroughs for cancer research in the past and will continue to do so in the future. </p><p>DOE鈥檚 supercomputers are playing a major role in cancer research. An algorithm developed by DOE鈥檚 Oak Ridge National Laboratory in partnership with the National Cancer Institute is speeding up classification of cancer pathology reports. The early results show that the algorithm dramatically reduces the time it takes for national cancer registries to process reports and the data to become available for public health monitoring. Another area where supercomputers have been essential has been modeling how cancer moves throughout the body. With the help of computers at the Oak Ridge Leadership Computing Facility and Argonne Leadership Computing Facility (both DOE Office of Science user facilities), researchers are using a full-body model of the human vascular system to track how cancer cells travel. </p></div> </div> </div> </div> </div> </div> <div class="block block-layout-builder block-inline-blocktemplate"> <div class="field field--entity_reference_revisions_entity_view field--field_paragraph_reference field field--name-field-paragraph-reference field--type-entity-reference-revisions field--label-hidden field__item"> <div class="paragraph paragraph--type--text-field paragraph--view-mode--default"> <div class="paragraph__column"> <div class="field field--text_default field--field_text field field--name-field-text field--type-text-long field--label-hidden field__item"><p>DOE-developed accelerator technology continues to advance the state of the art in external beam radiotherapy. Ultracompact accelerators that scientists first developed to make compact high energy physics accelerators have allowed accelerators to be made so small they can be mounted on an endoscope. Electronic brachytherapy delivers radiation directly to the tumor, which spares healthy tissues. Next-generation superconducting technologies developed for the Large Hadron Collider are being used to make beam delivery systems for bulky proton and ion accelerators more compact. This will enable more hospitals to afford these unique life-saving systems. </p><p>DOE produces many radioisotopes that are in short supply or available nowhere else and that are used in medical therapies. DOE also produces enriched stable isotopes that are used as starting materials for these radioisotopes. Some radioisotopes used in cancer therapy emit energetic particles that can cause a great deal of damage to a focused area, which is useful when targeting tumors. DOE produces two primary types of therapeutic radioisotopes: alpha particle emitters (e.g., actinium-225 and astatine-211) and beta particle emitters (e.g., rhenium-188 and yttrium-90). The introduction of alpha-emitters by DOE for the treatment of metastasized cancers has revolutionized cancer therapy treatments. Researchers from the DOE鈥檚 national laboratories and University Isotope Network have created new production processes to expand the supply of these radioisotopes. These new processes have enabled a number of active clinical drug trials. </p><p>DOE鈥檚 work enables private industry to enter mature isotope production markets. Medical imaging radioisotopes, like germanium-68 and strontium-82, allow physicians to identify tumors in people鈥檚 bodies in real time and see changes early on to better understand patient response. Both germanium-68 and strontium-82 were developed, and their markets were nurtured, by DOE. This action allowed DOE to transfer production to domestic private industry. These actions were in accordance with the DOE mission to act as a nonprofit governmental agency that does not compete with domestic private industry. </p><p>Nuclear physics research created the foundation for certain technologies that improve imaging and treatment monitoring. In breast cancer screening, nuclear medicine used alongside mammography reduces the number of false positive screening results. Based on research at DOE鈥檚 Jefferson Lab, scientists developed a tool to capture 3D molecular breast images at higher sensitivity. It provides up to six times better contrast of tumors, while maintaining the same or better image quality and halving patient radiation dose. Another cancer technology is based on material that scientists use to identify particles in experiments. Researchers have adapted it to monitor the radiation cancer patients receive in hard-to-reach areas. </p></div> </div> </div> </div> </div> </div> </div> </div> </div> </section> <section class="layout blade-section--fullwidth blade-section--blue--dark blade-section blade-section--text--white" id="feature"> <div class="blade-color " > <div class="grid-container"> <div class="grid-row"> <div class="grid-col"> <div class="block block-layout-builder block-inline-blocktemplate block-title--revisiting-the-cancer-distributed-learning-environment-candle-project"> <div class="paragraph-reference__heading-subheading-wrapper"><div class="paragraph-reference-heading-wrapper paragraph-reference-heading-wrapper--"><h2 class="block block-layout-builder block-inline-blocktemplate block-title--revisiting-the-cancer-distributed-learning-environment-candle-project"> Revisiting the CANcer Distributed Learning Environment (CANDLE) Project </h2></div></div> <div class="field field--entity_reference_revisions_entity_view field--field_paragraph_reference field field--name-field-paragraph-reference field--type-entity-reference-revisions field--label-hidden field__item"> <div class="paragraph paragraph--type--two-column-image-and-text paragraph--view-mode--default"> <div class="grid-row grid-gap"> <div class=" tablet:grid-col-8 tablet:order-first "> <div class="videoWrapper"> <iframe width="100%" height="auto" src="https://www.youtube.com/embed/6YSB4XJMKy0" title="YouTube video player" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share" referrerpolicy="strict-origin-when-cross-origin" allowfullscreen></iframe> </div> </div> <div class=" tablet:grid-col-4 tablet:order-1"> <div class="field field--text_default field--field_card_text field field--name-field-card-text field--type-text-long field--label-hidden field__item"><p>This podcast from the DOE鈥檚 Exascale Computing Project focuses on the CANcer Distributed Learning Environment, or CANDLE subproject. </p></div> <div class="card-link"> <a href="https://www.exascaleproject.org/exascale-computing-project-contributes-to-accelerating-cancer-research/" class="usa-button usa-button--outline">Learn More</a> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </section> <section class="layout blade-section--fullwidth blade-section--gray--dark blade-section blade-section--text--white" id="press-releases"> <div class="blade-color " > <div class="grid-container"> <div class="grid-row"> <div class="grid-col"> <div class="block block-layout-builder block-inline-blocktemplate block-title--press-releases"> <div class="paragraph-reference__heading-subheading-wrapper"><div class="paragraph-reference-heading-wrapper paragraph-reference-heading-wrapper--"><h2 class="block block-layout-builder block-inline-blocktemplate block-title--press-releases"> Press Releases </h2></div></div> <div class="field field--entity_reference_revisions_entity_view field--field_paragraph_reference field field--name-field-paragraph-reference field--type-entity-reference-revisions field--label-hidden field__item"> <div class="paragraph paragraph--type--collection paragraph--view-mode--default"> <div class="paragraph__column"> <ul class="collection collection--compact-icons js-view-dom-id-33cdcc584de3cd8ac73eff690d7360003482d2c9bef51ef5aa15d2b2af71637f"> <li class="collection-item"> <div class="collection-item--type-press-releases collection-item-wrapper"> <div class="collection-item__icon"> <div class="field field--fontawesome_icon_formatter field--field_fontawesome_icon field field--name-field-fontawesome-icon field--type-fontawesome-icon field--label-hidden field__item"><div class="fontawesome-icons"> <div class="fontawesome-icon"> <i class="far fa-newspaper" data-fa-transform="" data-fa-mask="" style="--fa-primary-color: #000000; 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