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<!DOCTYPE html> <html lang="en" dir="ltr" prefix="og: https://ogp.me/ns#"> <head> <meta charset="utf-8" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-8CT98BPDP3"></script> <script>window.dataLayer = window.dataLayer || [];function gtag(){dataLayer.push(arguments)};gtag("js", new Date());gtag("set", "developer_id.dMDhkMT", true);gtag("config", "G-8CT98BPDP3", {"groups":"default","page_placeholder":"PLACEHOLDER_page_location","allow_ad_personalization_signals":false});</script> <meta name="description" content="Current research interests include how the tumour microenvironment influences radiotherapy and chemotherapy outcomes with particular focus on oxygen, extravascular drug distribution and DNA repair. These programs have required creative innovations in technology, including development and application of 3D tissue models and high throughput robotic instrumentation within the multi-disciplinary laboratory. Dr." /> <link rel="canonical" href="https://www.bccrc.ca/dept/io/labs/minchinton-lab" /> <meta name="Generator" content="Drupal 10 (https://www.drupal.org)" /> <meta name="MobileOptimized" content="width" /> <meta name="HandheldFriendly" content="true" /> <meta name="viewport" content="width=device-width, initial-scale=1.0" /> <style>.logo a {background-image: url(/dept/io/sites/integrativeoncology/files/BCClogo_Research_IntegrativeOncology_RGB.png);background-size: contain;}body .region__network .logo a {background-size: contain}</style> <link rel="icon" href="/dept/io/themes/custom/bccrc/favicon.ico" type="image/vnd.microsoft.icon" /> <title>Minchinton Lab | Integrative Oncology</title> <link rel="stylesheet" href="//use.typekit.net/rew6qot.css"> <link rel="stylesheet" media="all" href="/dept/io/dept/io/sites/integrativeoncology/files/css/css_Bxn9zpdS07My99x7G76QyiQFY-SQtLPW6RDCCblqJIQ.css?delta=0&language=en&theme=bccrc&include=eJxFyDEOwCAIAMAPWXkTKEETqgRk8Pcde-NRa95AdBPqE-fqXFIMHcXRRkD3NNT6T81lSTpjcC9x4_ALhMEfHl0cpA" /> <link rel="stylesheet" media="all" href="https://cdnjs.cloudflare.com/ajax/libs/font-awesome/4.7.0/css/font-awesome.min.css" /> <link rel="stylesheet" media="all" href="/dept/io/dept/io/sites/integrativeoncology/files/css/css_b1Imd5Zfo6d9UtggtC_ak93-Ac2c67PnthKR5yWdzt8.css?delta=2&language=en&theme=bccrc&include=eJxFyDEOwCAIAMAPWXkTKEETqgRk8Pcde-NRa95AdBPqE-fqXFIMHcXRRkD3NNT6T81lSTpjcC9x4_ALhMEfHl0cpA" /> </head> <body class="colour--emerald not-front path--node page--lab"> <a href="#main-content" class="visually-hidden focusable skip-link"> Skip to main content </a> <div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas> <div class="main-container"> <header class="page--lab page"> <div class="region__header--inner region--inner"> <section id="block-bccrc-breadcrumbs" class="block block--system-breadcrumb-block block-bccrc-breadcrumbs"> <nav class="breadcrumb" role="navigation" aria-labelledby="system-breadcrumb"> <h2 id="system-breadcrumb" class="visually-hidden">Breadcrumb</h2> <ol> <li> <a href="/dept/io/">Integrative Oncology</a> </li> <li> Minchinton Lab </li> </ol> </nav> </section> <section id="block-bccrc-page-title" class="block block--page-title-block block-bccrc-page-title"> <h1><span>Minchinton Lab</span> </h1> </section> </div> </header> <section class="region region__highlight"> <div class="region__highlight--inner region--inner"> <div data-drupal-messages-fallback class="hidden"></div> </div> </section> <main role="main"> <a id="main-content" tabindex="-1"></a> <div class="layout-content"> <section class="region region__content"> <div class="region__content--inner region--inner"> <section id="block-bccrc-content" class="block block--system-main-block block-bccrc-content"> <article class="node node--lab full"> <div class="node__inner"> <footer class="node"> <aside> <a href="/dept/io/people/andrew-minchinton" class="button"><span>Andrew Minchinton, PhD</span> </a> <div class="field field--field_phone_number"><a href="tel:604.675.8032">604.675.8032</a></div> <div class="field field--field_admin_contact"> <div class="above field--label">Admin Contact</div> <div> <div class="field field--item field--field_admin_contact"><article class="node node--profile assistant"> <div class="field--name"> <span>Caitlin Clugston</span> </div> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Administrative Coordinator</div> </div> </article> </div> </div> </div> </aside> </footer> <div class="node__main"> <div class="field field--body"><p>Current research interests include how the tumour microenvironment influences radiotherapy and chemotherapy outcomes with particular focus on oxygen, extravascular drug distribution and DNA repair. These programs have required creative innovations in technology, including development and application of 3D tissue models and high throughput robotic instrumentation within the multi-disciplinary laboratory. Dr. Minchinton has been involved in three drug discovery programs and is currently leading an international effort to develop a tumour-targeted inhibitor of DNA dependent protein kinase (DNA-PK), a pivotal protein involved in non-homologous end-joining of DNA double strand breaks, the lethal radiotherapy-induced DNA lesion.</p><p>Other currently funded collaborative projects involve exploring FLASH radiotherapy with colleagues in the Medical Physics and Radiation Oncology departments at BC Cancer. This new area of research involves delivering radiotherapy at ultra-high dose rates in an effort to minimize normal tissue damage and produce an improved therapeutic index. In partnership with researchers in the Department of Physics and Astronomy at UBC, Dr. Minchinton鈥檚 lab has developed novel applications of MRI for monitoring the tumour microenvironment, including biomarkers of vascular function and oxygenation. Another project is working with collaborators at the University of Auckland to explore how inhibitors of the electron transport chain can circumvent hypoxia-induced radioresistance.</p><p>Dr Minchinton has published over 100 peer-reviewed articles, 5 patents and currently holds two CIHR operating grants as well as funding from the CCSRI and BC Cancer Foundation.</p><p>Minchinton Lab is looking to recruit master's students and doctoral students.</p></div> </div> </div> </article> <section id="people" class="layout layout__grid"><h2 class="section__title">Members</h2><h3 class="subsection__title">Faculty/Leaders</h3><div class="flexgrid"><article class="node node--profile teaser"> <a class="picture" href="/dept/io/people/andrew-minchinton" ><figure> <img loading="lazy" src="/dept/io/sites/integrativeoncology/files/styles/profile/public/2019-10/aim2.PNG?itok=lkH-ywLM" width="580" height="460" alt="" /> </figure></a> <section> <h3 class="node__title"> <a href="/dept/io/people/andrew-minchinton" rel="bookmark">Andrew Minchinton, PhD</a> </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Distinguished Scientist</div> </div> <div class="contact"> <div class="field field--field_phone_number"><a href="tel:604.675.8032">604.675.8032</a></div> <a href= "https://www.bccrc.ca/dept/io/contact/188" class="more">Send message</a> <a href="/dept/io/people/andrew-minchinton" class="more" rel="bookmark">Bio <i class="fa fa-chevron-right"></i></a> </div> </section> </article> </div><h3 class="subsection__title">Staff</h3><div class="flexgrid"><article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/io/sites/integrativeoncology/files/styles/profile/public/2019-10/IO_JudithBanath.jpeg?itok=r4WriGRp" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Dr. Judith Banath </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Research Assistant</div> </div> <div class="contact"> <a href= "https://www.bccrc.ca/dept/io/contact/81" class="more">Send message</a> </div> </section> </article> <article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/io/sites/integrativeoncology/files/styles/profile/public/2024-05/Alastair%20kyle_0.jpg?itok=JyIH2N4V" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Dr. Alastair Kyle </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Staff Scientist</div> </div> <div class="contact"> <a href= "https://www.bccrc.ca/dept/io/contact/82" class="more">Send message</a> </div> </section> </article> </div><h3 class="subsection__title">Students/Trainees</h3><div class="flexgrid"><article class="node node--profile teaser"> <figure> <img loading="lazy" src="/dept/io/sites/integrativeoncology/files/styles/profile/public/2019-05/BCPCM-portrait.png?itok=nEtgTObd" width="580" height="460" alt="" /> </figure> <section> <h3 class="node__title"> Sevin Teymori </h3> <div class="field field--field_profile_title"> <div class="field field--item field--field_profile_title">Graduate Student</div> </div> <div class="contact"> </div> </section> </article> </div></section> <section id="publications" class="layout layout__expanding layout__publications"><h2 class="section__title">Selected Publications</h2><button class="icon" data-expand></button><div class="field field--field_text"> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/30836046" target="_blank" rel="bookmark">Peggy Louise Olive 1948-2018.</a> </h2> <div class="field field--field_journal">International journal of radiation biology, 2019</div> <div class="field field--field_authors">Minchinton, Andrew, Bennewith, Kevin, Hill, Richard</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/30836046" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/16862189" target="_blank" rel="bookmark">Drug penetration in solid tumours.</a> </h2> <div class="field field--field_journal">Nature reviews. Cancer, 2006</div> <div class="field field--field_authors">Minchinton, Andrew I, Tannock, Ian F</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/16862189" target="_blank">Learn More</a></div> </article> <article class="node publication teaser"> <h2 class="node__title"> <a href="https://www.ncbi.nlm.nih.gov/pubmed/15374965" target="_blank" rel="bookmark">Microregional effects of gemcitabine in HCT-116 xenografts.</a> </h2> <div class="field field--field_journal">Cancer research, 2004</div> <div class="field field--field_authors">Huxham, Lynsey A, Kyle, Alastair H, Baker, Jennifer H E, Nykilchuk, Lani K, Minchinton, Andrew I</div> <div class="field field--field_pubmed_id"><a href="https://www.ncbi.nlm.nih.gov/pubmed/15374965" target="_blank">Learn More</a></div> </article> </div></section> <section class="has-logos layout layout__sponsors"> <h2 class="section__title">Sponsors</h2> <div class="flexgrid"> <div class="field--item field--field_sponsors"><a href="http://www.cihr-irsc.gc.ca/e/193.html" target="_blank"> <img loading="lazy" src="/dept/io/dept/io/sites/integrativeoncology/files/styles/square_logo/public/2019-10/CIHR.png?itok=VlHMC0G9" width="200" height="129" alt="" /> </a></div> <div class="field--item field--field_sponsors"><a href="http://www.cancer.ca" target="_blank"> <img loading="lazy" src="/dept/io/dept/io/sites/integrativeoncology/files/styles/square_logo/public/2019-08/Canadian%20Cancer%20Society.png?itok=0-JAmpiq" width="200" height="200" alt="" /> </a></div> <div class="field--item field--field_sponsors"><a href="https://www.msfhr.org/" target="_blank"> <img loading="lazy" src="/dept/io/dept/io/sites/integrativeoncology/files/styles/square_logo/public/2019-08/MSFHR.png?itok=qtpauLPP" width="200" height="84" alt="" /> </a></div> </div> </section> </section> </div> </section> </div> <a class="top" href="#main-content">Back to top</a> </main> <section class="region region__cta"> <div class="region__cta--inner region--inner"> <section id="block-sitecalltoaction" class="block block--block-contenta8a59224-4648-42d5-b71c-294b3c630d8a block-sitecalltoaction"> <div class="field field--body"><p>BC Cancer Foundation is the fundraising partner of BC Cancer, which includes BC Cancer Research. 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