Study finds how obstructive sleep apnea may increase risk of abdominal aortic aneurysms

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180.9 389.2 48zM364.4 421.8h39.1L151.1 88h-42L364.4 421.8z" fill="#fff"/></svg> </a></li> <li class="whatsapp"><a data-whatsapp href="javascript:void(0);" aria-label="whatsapp_ani" rel="noopener"></a></li> </ul> </div> <header> <div data-news-id="801975" class="h-0 w-0" style="height: 0;width: 0;"></div> <div class="img-container"> <img data-src="https://d3lzcn6mbbadaf.cloudfront.net/media/details/ANI-20240926144247.jpg" src="https://d3lzcn6mbbadaf.cloudfront.net/media/details/ANI-20240926144247.jpg" alt="Representative Image" title="Study finds how obstructive sleep apnea may increase risk of abdominal aortic aneurysms" class="lazy img-responsive"> </div> <small style="margin: 0rem 0 2rem; display: inline-block; color: #727272; font-size: 1.48rem;"><i>Representative Image</i></small> </header> <article> <div class="content"> <h1 itemprop="headline" class="title">Study finds how obstructive sleep apnea may increase risk of abdominal aortic aneurysms</h1> <p class="time"><span class="time-gray"> <span itemprop="author creator" itemscope itemtype="http://schema.org/Person"> <span itemprop="name">ANI |</span> </span> Updated: </span><span class="time-red" itemprop="dateModified">Sep 26, 2024 23:40 </span><span class="first red-ist"> IST</span> </p> </div> <div class="hidden-md hidden-lg hidden-xl"> <a target="_blank" class="green-btn" href="https://whatsapp.com/channel/0029Va7q7004dTnMVl9H9r0o">ANI News <svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path d="M256 48a208 208 0 1 1 0 416 208 208 0 1 1 0-416zm0 464A256 256 0 1 0 256 0a256 256 0 1 0 0 512zM369 209c9.4-9.4 9.4-24.6 0-33.9s-24.6-9.4-33.9 0l-111 111-47-47c-9.4-9.4-24.6-9.4-33.9 0s-9.4 24.6 0 33.9l64 64c9.4 9.4 24.6 9.4 33.9 0L369 209z" fill="#fff"/></svg> Join our Whatsapp channel</a></div> <div class="content count-br" itemprop="articleBody"> <br/><p>Washington [US], September 26 (ANI): Obstructive <a href="/topic/sleep-apnea">sleep apnea</a> may increase the chance of developing abdominal aortic <a href="/topic/aneurysms">aneurysms</a>, according to experts from the University of Missouri School of Medicine and NextGen Precision Health.<br/>Abdominal aortic <a href="/topic/aneurysms">aneurysms</a> form when the major artery, the <a href="/topic/aorta">aorta</a>, expands and potentially ruptures, resulting in life-threatening internal haemorrhage. Obstructive sleep apnoea is a chronic disorder in which patients stop and start breathing while sleeping, increasing the risk of cardiovascular complications. Citing studies indicating a higher occurrence of abdominal aortic <a href="/topic/aneurysms">aneurysms</a> in people with obstructive <a href="/topic/sleep-apnea">sleep apnea</a>, MU researchers investigated the link between the two using mouse models.<br/>The research team found that intermittent hypoxia - when the body isn't getting enough oxygen for a given period of time - caused by obstructive <a href="/topic/sleep-apnea">sleep apnea</a> increased the susceptibility of mice to develop abdominal aortic <a href="/topic/aneurysms">aneurysms</a>. <br/></p><div id="M58040ScriptRootC713570"> </div> <script src="https://jsc.mgid.com/a/n/aninews.in.713570.js" async></script><p>"Chronic intermittent hypoxia by itself is not enough to cause abdominal aortic <a href="/topic/aneurysms">aneurysms</a>, but for a patient with obstructive <a href="/topic/sleep-apnea">sleep apnea</a> who also has additional metabolic problems like obesity, our findings suggest it may help degrade aortic structures and promote aneurysm development," said Luis Martinez-Lemus, study author and a professor of medical pharmacology and physiology. <br/>Intermittent hypoxia happens during obstructive <a href="/topic/sleep-apnea">sleep apnea</a> when throat muscles relax and block the flow of air into the lungs. According to the research, the loss of oxygen triggers certain enzymes called MMPs. The increased enzyme activity can degrade the extracellular matrix, which acts like a cell scaffolding network, weakening the <a href="/topic/aorta">aorta</a>. <br/>"Patients with abdominal aortic <a href="/topic/aneurysms">aneurysms</a> usually don't notice any symptoms, except for some back and belly pain, until the aneurysm bursts. Once that happens, it's crucial to get the patient to surgery quickly so doctors can repair the <a href="/topic/aorta">aorta</a>," said Neekun Sharma, the lead author of the study. "Learning how these <a href="/topic/aneurysms">aneurysms</a> develop can help us find ways to monitor or slow down their progression, especially for patients who have obstructive <a href="/topic/sleep-apnea">sleep apnea</a>." (ANI)<br/></p> </div> </article> <div class="social-tags"> <div class="tags"> <div class="box-head"> <h3 class="title">Tags</h3> </div> <div class="box-tag"> <a href="/topic/aneurysms/"> <p class="text">aneurysms</p> </a> </div> <div class="box-tag"> <a href="/topic/sleep-apnea/"> <p class="text"> sleep apnea</p> </a> </div> <div class="box-tag"> <a href="/topic/risk-factors/"> <p class="text"> risk factors</p> </a> </div> <div class="box-tag"> <a href="/topic/aorta/"> <p class="text"> aorta</p> </a> </div> <div class="box-tag"> <a href="/topic/obstructive-sleep-apnea/"> <p class="text"> obstructive sleep apnea</p> </a> </div> </div> </div> <div class="social"> <div class="addthis_inline_share_toolbox"></div> </div> </div>   </div> <div class="col-md-4 col-sm-4 col-xs-12 right-block">   <style type="text/css"> .custom-w { width: 320px;} </style> <script async src="https://pagead2.googlesyndication.com/pagead/js/adsbygoogle.js?client=ca-pub-5895345606977732" 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Study finds how obstructive sleep apnea may increase risk of abdominal aortic aneurysms