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An 83 year old woman was referred to our hospital in June 1999 for further examination and treatment of oesophageal tumour. Although a physical examination and laboratory data showed no significant abnormalities, endoscopic observation revealed two slightly elevated submucosal tumour-like lesions of the oesophagus. Tissue specimens were obtained by endoscopic mucosal resection of the oesophagus using a cap fitted panendoscope. The lesions were composed of diffuse small atypical lymphoid cells—that is, centrocyte-like cells—which were stained with CD20, L26, BCL-2, and κ, but not with CD3, CD5, CD10, or cyclin D1. Monoclonality was detected by polymerase chain reaction analysis using the primer for CDR-3 of immunoglobulin H and diagnosed as low grade MALT lymphoma of the oesophagus. The tumours were considered to be completely resected and therefore additional treatment was not administered. The patient is alive and well 22 months after treatment and diagnosis." /> <meta name="DC.Contributor" content="S Hosaka" /> <meta name="DC.Contributor" content="N Nakamura" /> <meta name="DC.Contributor" content="T Akamatsu" /> <meta name="DC.Contributor" content="T Fujisawa" /> <meta name="DC.Contributor" content="Y Ogiwara" /> <meta name="DC.Contributor" content="K Kiyosawa" /> <meta name="DC.Contributor" content="E Hidaka" /> <meta name="DC.Contributor" content="H Ota" /> <meta name="DC.Contributor" content="T Katsuyama" /> <meta name="DC.Contributor" content="H Inagaki" /> <meta name="article:published_time" content="2002-08-01" /> <meta name="article:section" content="Case report" /> <meta name="citation_title" content="A case of primary low grade mucosa associated lymphoid tissue (MALT) lymphoma of the oesophagus" /> <meta name="citation_abstract" lang="en" content="<p>We report a very rare case of primary low grade mucosa associated lymphoid tissue (MALT) lymphoma of the oesophagus. An 83 year old woman was referred to our hospital in June 1999 for further examination and treatment of oesophageal tumour. Although a physical examination and laboratory data showed no significant abnormalities, endoscopic observation revealed two slightly elevated submucosal tumour-like lesions of the oesophagus. Tissue specimens were obtained by endoscopic mucosal resection of the oesophagus using a cap fitted panendoscope. The lesions were composed of diffuse small atypical lymphoid cells—that is, centrocyte-like cells—which were stained with CD20, L26, BCL-2, and κ, but not with CD3, CD5, CD10, or cyclin D1. Monoclonality was detected by polymerase chain reaction analysis using the primer for CDR-3 of immunoglobulin H and diagnosed as low grade MALT lymphoma of the oesophagus. The tumours were considered to be completely resected and therefore additional treatment was not administered. The patient is alive and well 22 months after treatment and diagnosis.</p>" /> <meta name="citation_journal_title" content="Gut" /> <meta name="citation_publisher" content="BMJ Publishing Group" /> <meta name="citation_publication_date" content="2002/08/01" /> <meta name="citation_mjid" content="gutjnl;51/2/281" /> <meta name="citation_id" content="51/2/281" /> <meta name="citation_public_url" content="https://gut.bmj.com/content/51/2/281" /> <meta name="citation_abstract_html_url" content="https://gut.bmj.com/content/51/2/281.abstract" /> <meta name="citation_full_html_url" content="https://gut.bmj.com/content/51/2/281.full" /> <meta name="citation_pdf_url" content="https://gut.bmj.com/content/gutjnl/51/2/281.full.pdf" /> <meta name="citation_issn" content="0017-5749" /> <meta name="citation_issn" content="1468-3288" /> <meta name="citation_doi" content="10.1136/gut.51.2.281" /> <meta name="citation_pmid" content="12117895" /> <meta name="citation_volume" content="51" /> <meta name="citation_issue" content="2" /> <meta name="citation_article_type" content="Other" /> <meta name="citation_section" content="Case report" /> <meta name="citation_firstpage" content="281" /> <meta name="citation_lastpage" content="284" /> <meta name="citation_author" content="S Hosaka" /> <meta name="citation_author_institution" content="Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan" /> <meta name="citation_author" content="N Nakamura" /> <meta name="citation_author_institution" content="Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan" /> <meta name="citation_author" content="T Akamatsu" /> <meta name="citation_author_institution" content="Department of Endoscopy, Shinshu University Hospital, Matsumoto, Japan" /> <meta name="citation_author" content="T Fujisawa" /> <meta name="citation_author_institution" content="Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan" /> <meta name="citation_author" content="Y Ogiwara" /> <meta name="citation_author_institution" content="Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan" /> <meta name="citation_author" content="K Kiyosawa" /> <meta name="citation_author_institution" content="Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan" /> <meta name="citation_author" content="E Hidaka" /> <meta name="citation_author_institution" content="Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan" /> <meta name="citation_author" content="H Ota" /> <meta name="citation_author_institution" content="Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan" /> <meta name="citation_author" content="T Katsuyama" /> <meta name="citation_author_institution" content="Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan" /> <meta name="citation_author" content="H Inagaki" /> <meta name="citation_author_institution" content="Department of Pathology, Nagoya City University Medical School, Nagoya, Japan" /> <meta name="citation_reference" content="Brady LW. 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Lancet2001;357:4014–15." /> <meta name="twitter:title" content="A case of primary low grade mucosa associated lymphoid tissue (MALT) lymphoma of the oesophagus" /> <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:image" content="https://gut.bmj.com/sites/default/files/highwire/gutjnl/51/2.cover.gif" /> <meta name="twitter:description" content="We report a very rare case of primary low grade mucosa associated lymphoid tissue (MALT) lymphoma of the oesophagus. An 83 year old woman was referred to our hospital in June 1999 for further examination and treatment of oesophageal tumour. Although a physical examination and laboratory data showed no significant abnormalities, endoscopic observation revealed two slightly elevated submucosal tumour-like lesions of the oesophagus. Tissue specimens were obtained by endoscopic mucosal resection of the oesophagus using a cap fitted panendoscope. The lesions were composed of diffuse small atypical lymphoid cells—that is, centrocyte-like cells—which were stained with CD20, L26, BCL-2, and κ, but not with CD3, CD5, CD10, or cyclin D1. Monoclonality was detected by polymerase chain reaction analysis using the primer for CDR-3 of immunoglobulin H and diagnosed as low grade MALT lymphoma of the oesophagus. The tumours were considered to be completely resected and therefore additional treatment was not administered. The patient is alive and well 22 months after treatment and diagnosis." /> <meta name="og-title" property="og:title" content="A case of primary low grade mucosa associated lymphoid tissue (MALT) lymphoma of the oesophagus" /> <meta name="og-url" property="og:url" content="https://gut.bmj.com/content/51/2/281" /> <meta name="og-site-name" property="og:site_name" content="Gut" /> <meta name="og-description" property="og:description" content="We report a very rare case of primary low grade mucosa associated lymphoid tissue (MALT) lymphoma of the oesophagus. An 83 year old woman was referred to our hospital in June 1999 for further examination and treatment of oesophageal tumour. Although a physical examination and laboratory data showed no significant abnormalities, endoscopic observation revealed two slightly elevated submucosal tumour-like lesions of the oesophagus. Tissue specimens were obtained by endoscopic mucosal resection of the oesophagus using a cap fitted panendoscope. The lesions were composed of diffuse small atypical lymphoid cells—that is, centrocyte-like cells—which were stained with CD20, L26, BCL-2, and κ, but not with CD3, CD5, CD10, or cyclin D1. Monoclonality was detected by polymerase chain reaction analysis using the primer for CDR-3 of immunoglobulin H and diagnosed as low grade MALT lymphoma of the oesophagus. The tumours were considered to be completely resected and therefore additional treatment was not administered. The patient is alive and well 22 months after treatment and diagnosis." /> <meta name="og-type" property="og:type" content="article" /> <meta name="og-image" property="og:image" content="https://gut.bmj.com/sites/default/files/highwire/gutjnl/51/2.cover.gif" /> <link rel="alternate" type="application/vnd.ms-powerpoint" title="Powerpoint" href="/content/51/2/281.ppt" /> <title>A case of primary low grade mucosa associated lymphoid tissue (MALT) lymphoma of the oesophagus | Gut</title> <link type="text/css" rel="stylesheet" href="/sites/default/files/advagg_css/css__KGQXfyVQx6ROYyuABaw3EldGujxo77DHeyVLSXRuWQg__RHEb_wh5Am_m47OXrIid5l_odaVtTV0NCc_a-QHU5o0__RBpwsggTa-66iCd391Lg7-ZmaIvHPOUAGYyVtdCScb8.css" media="all" />  <script src="https://cookie-cdn.cookiepro.com/scripttemplates/otSDKStub.js" type="text/javascript" charset="UTF-8" data-domain-script="565e50dd-f6e9-46d6-91cd-5c40a270264f"></script> <script type="text/javascript"> function OnetrustAdsConsent(){ if(googletag.apiReady){ //console.log("GoogleTag API ready") googletag.pubads().disableInitialLoad(); if(OptanonActiveGroups.match(/,4,/)){ googletag.pubads().setRequestNonPersonalizedAds(0); //googletag.pubads().refresh(); } else{ googletag.pubads().setRequestNonPersonalizedAds(1); googletag.pubads().refresh(); } } else{ OnetrustAdsConsent(); } } function OptanonWrapper() { OnetrustAdsConsent(); } </script>  <script type="text/javascript" src="/sites/default/files/advagg_js/js__DdxPgqGimsdUot2QWNz_pGsHzqNGpx6RMCWHpL8YWkg__c6zfK6oHHbLpTal5PdQxeQI3xGoCM8IXWtEHwIZr560__RBpwsggTa-66iCd391Lg7-ZmaIvHPOUAGYyVtdCScb8.js"></script> <script type="text/javascript" src="https://securepubads.g.doubleclick.net/tag/js/gpt.js"></script> <script type="text/javascript" src="/sites/default/files/advagg_js/js__RplUf5n1SHvT_MHHQProZaAaHxo7a_9YZuaKWYnqVeQ__t8vznsHJmtJcTuSP5JnWJ92mdmFUGaXxtxwBatvNwmc__RBpwsggTa-66iCd391Lg7-ZmaIvHPOUAGYyVtdCScb8.js"></script> <script type="text/javascript" src="https://d1bxh8uas1mnw7.cloudfront.net/assets/embed.js"></script> <script type="text/javascript" src="/sites/default/files/advagg_js/js__dNRQ0P3mzXReUF4250f2vTnR4K_GFl-M8oB_3K2j1fI__-eoy5F1B5hwy20bysxSQQrr2HBlAB7kgfK-OIh8VRRA__RBpwsggTa-66iCd391Lg7-ZmaIvHPOUAGYyVtdCScb8.js"></script> <script type="text/javascript" defer="defer" async="async" src="//cdn.foxycart.com/bmjpg.ecommerce.highwire.org/loader.js"></script> <script type="text/javascript" async="async" src="https://scholar.google.com/scholar_js/casa.js"></script> <script type="text/javascript"> <![CDATA[//><!]]> </script> <script type="text/javascript"> <![CDATA[//><!]]> </script> <script type="text/javascript"> <![CDATA[//><!]]> </script> <script type="text/javascript"> <![CDATA[//><!]]> </script> <script type="text/javascript"> <![CDATA[//><!]]> </script> <script type="text/javascript"> <![CDATA[//><!]]> </script> <script type="text/javascript"> <![CDATA[//><!]]> </script> <script type="text/javascript"> <![CDATA[//><!]]> </script> <script type="text/javascript"> <![CDATA[//><!]]> </script> <script type="text/javascript"> <![CDATA[//><!]]> </script> <script type="text/javascript"> <![CDATA[//><!]]> </script>   <script> let cookies = parseCookies(); let bmj_uuid = cookies.bmj_uuid; let bmj_ppid = cookies.bmj_ppid; window.dataLayer = window.dataLayer || []; const anonMailId = 'e3b0c44298fc1c149afbf4c8996fb92427ae41e4649b934ca495991b7852b855'; function checkUserLoginStatus(dataLayer) { const userMail = dataLayer.find((item) => item.user)?.user?.mail; if (!userMail) { return false; } return userMail !== anonMailId; } let nonAnonMailId = ((dataLayer.find(item => item.user)?.user)?.mail) === anonMailId ? null : (dataLayer.find(item => item.user)?.user)?.mail; let userId = ((dataLayer.find(item => item.user)?.user)?.['data-ics']) ?? 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class="field-items"><div class="field-item even">Case report</div></div></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-highwire-article-citation col-mobile-10 col-narrow-10 col-normal-11 article-title" > <div class="pane-content"> <div class="highwire-article-citation highwire-citation-type-highwire-article node147842" data-node-nid="147842" id="node-147842--2124583508" data-pisa="gutjnl;51/2/281" data-pisa-master="gutjnl;51/2/281" data-apath="/gutjnl/51/2/281.atom"><cite class="highwire-cite highwire-cite-highwire-article highwire-citation-bmjj-title clearfix"> <div class="highwire-cite-title">A case of primary low grade mucosa associated lymphoid tissue (MALT) lymphoma of the oesophagus</div> <span class="highwire-cite-access"><span class="highwire-citation-access highwire-citation-access-check" data-pisa-id="gutjnl;51/2/281" data-atom-uri="/gutjnl/51/2/281.atom" data-request-view="full"></span></span> </cite> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-highwire-panel-tabs-container col-narrow-12 clear" > <div class="pane-content"> <div data-panels-ajax-tab-preloaded="jnl_template_bmjj_tab_art" id="panels-ajax-tab-container-highwire_article_tabs" class="panels-ajax-tab-container"><div class="panels-ajax-tab-loading" style ="display:none"><img class="loading" src="https://gut.bmj.com/sites/all/modules/contrib/panels_ajax_tab/images/loading.gif" alt="Loading" title="Loading" /></div><div class="panels-ajax-tab-wrap-jnl_template_bmjj_tab_art"><div class="panel-display panel-1col clearfix" > <div class="panel-panel panel-col"> <div><div class="panel-pane pane-highwire-markup author-affiliates col-narrow-12 author-affiliates-corresp article" > <div class="pane-content"> <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div xmlns:xhtml="http://www.w3.org/1999/xhtml" class="contributors"><ol class="contributor-list" id="contrib-group-1"><li class="contributor" id="contrib-1"><span class="name">S Hosaka</span><a id="xref-aff-1-1" class="xref-aff" href="#aff-1">1</a>, </li><li class="contributor" id="contrib-2"><span class="name">N Nakamura</span><a id="xref-aff-1-2" class="xref-aff" href="#aff-1">1</a>, </li><li class="contributor" id="contrib-3"><span class="name">T Akamatsu</span><a id="xref-aff-2-1" class="xref-aff" href="#aff-2">2</a>, </li><li class="contributor" id="contrib-4"><span class="name">T Fujisawa</span><a id="xref-aff-1-3" class="xref-aff" href="#aff-1">1</a>, </li><li class="contributor" id="contrib-5"><span class="name">Y Ogiwara</span><a id="xref-aff-1-4" class="xref-aff" href="#aff-1">1</a>, </li><li class="contributor" id="contrib-6"><span class="name">K Kiyosawa</span><a id="xref-aff-1-5" class="xref-aff" href="#aff-1">1</a>, </li><li class="contributor" id="contrib-7"><span class="name">E Hidaka</span><a id="xref-aff-3-1" class="xref-aff" href="#aff-3">3</a>, </li><li class="contributor" id="contrib-8"><span class="name">H Ota</span><a id="xref-aff-3-2" class="xref-aff" href="#aff-3">3</a>, </li><li class="contributor" id="contrib-9"><span class="name">T Katsuyama</span><a id="xref-aff-3-3" class="xref-aff" href="#aff-3">3</a>, </li><li class="last" id="contrib-10"><span class="name">H Inagaki</span><a id="xref-aff-4-1" class="xref-aff" href="#aff-4">4</a></li></ol><ol class="affiliation-list"><li class="aff"><a id="aff-1" name="aff-1"></a><address><sup>1</sup>Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan </address></li><li class="aff"><a id="aff-2" name="aff-2"></a><address><sup>2</sup>Department of Endoscopy, Shinshu University Hospital, Matsumoto, Japan </address></li><li class="aff"><a id="aff-3" name="aff-3"></a><address><sup>3</sup>Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan </address></li><li class="aff"><a id="aff-4" name="aff-4"></a><address><sup>4</sup>Department of Pathology, Nagoya City University Medical School, Nagoya, Japan</address></li></ol><ol class="corresp-list"><li class="corresp" id="corresp-1">Correspondence to:<br/> Dr T Akamatsu, Department of Endoscopy, Shinshu University Hospital, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan;<br/> <span class="em-link"><span class="em-addr">ta07260{at}hsp.md.shinshu-u.ac.jp</span></span></li></ol></div></div></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-highwire-markup abstract-with-bc" > <div class="pane-content"> <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" id="content-block" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div class="article abstract-view "><span class="highwire-journal-article-marker-start"></span><div class="section abstract" id="abstract-1"><h2>Abstract</h2><p id="p-1">We report a very rare case of primary low grade mucosa associated lymphoid tissue (MALT) lymphoma of the oesophagus. An 83 year old woman was referred to our hospital in June 1999 for further examination and treatment of oesophageal tumour. Although a physical examination and laboratory data showed no significant abnormalities, endoscopic observation revealed two slightly elevated submucosal tumour-like lesions of the oesophagus. Tissue specimens were obtained by endoscopic mucosal resection of the oesophagus using a cap fitted panendoscope. The lesions were composed of diffuse small atypical lymphoid cells—that is, centrocyte-like cells—which were stained with CD20, L26, BCL-2, and κ, but not with CD3, CD5, CD10, or cyclin D1. Monoclonality was detected by polymerase chain reaction analysis using the primer for CDR-3 of immunoglobulin H and diagnosed as low grade MALT lymphoma of the oesophagus. The tumours were considered to be completely resected and therefore additional treatment was not administered. The patient is alive and well 22 months after treatment and diagnosis.</p></div><ul class="kwd-group KWD"><li class="kwd">mucosa associated lymphoid tissue</li><li class="kwd">lymphoma</li><li class="kwd">oesophagus</li><li class="kwd">primary oesophageal lymphoma</li><li class="kwd">endoscopic mucosal resection</li><li class="kwd">monoclonality</li></ul><ul class="kwd-group ABR"><li class="kwd">MALT, mucosa associated lymphoid tissue</li><li class="kwd">PCR, polymerase chain reaction</li><li class="kwd">Ig, immunoglobulin</li></ul><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right" > <div class="pane-content"> <div id="dfp-ad-mpu-wrapper" class="dfp-tag-wrapper"> <div id="dfp-ad-mpu" class="dfp-tag-wrapper"> <script type="text/javascript"> googletag.cmd.push(function() { googletag.display("dfp-ad-mpu"); }); </script> </div> </div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-custom pane-1" > <div class="pane-content"> <p><a href="https://doi.org/10.1136/gut.51.2.281" target="_new">https://doi.org/10.1136/gut.51.2.281</a></p> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-highwire-altmetrics" > <h2 class="pane-title">Statistics from Altmetric.com</h2> <div class="pane-content"> <div data-badge-details="right" data-badge-type="medium-donut" data-doi="10.1136/gut.51.2.281" data-hide-no-mentions="true" class="altmetric-embed"></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-bmjj-jumplinks" > <div class="pane-content"> <div class="highwire-list-wrapper"><div class="highwire-list"><ul></ul></div></div> </div> </div> <div class="panel-separator"></div><div class="panel-pane pane-custom pane-2 permissions-box" > <h2 class="pane-title">Request Permissions</h2> <div class="pane-content"> <p>If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. 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href="/keyword/mucosa-associated-lymphoid-tissue" class="hw-term hw-article-keyword hw-article-keyword-mucosa-associated-lymphoid-tissue" rel="nofollow">mucosa associated lymphoid tissue</a></li><li class="kwd"><a href="/keyword/lymphoma" class="hw-term hw-article-keyword hw-article-keyword-lymphoma" rel="nofollow">lymphoma</a></li><li class="kwd"><a href="/keyword/oesophagus" class="hw-term hw-article-keyword hw-article-keyword-oesophagus" rel="nofollow">oesophagus</a></li><li class="kwd"><a href="/keyword/primary-oesophageal-lymphoma" class="hw-term hw-article-keyword hw-article-keyword-primary-oesophageal-lymphoma" rel="nofollow">primary oesophageal lymphoma</a></li><li class="kwd"><a href="/keyword/endoscopic-mucosal-resection" class="hw-term hw-article-keyword hw-article-keyword-endoscopic-mucosal-resection" rel="nofollow">endoscopic mucosal resection</a></li><li class="kwd"><a href="/keyword/monoclonality" class="hw-term hw-article-keyword hw-article-keyword-monoclonality" 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