CINXE.COM

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<img class="lazyload" src="data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7" data-srcset="https://www.columbiacardiology.org/sites/default/files/styles/cola_media_40_21_9/public/media/images/2018-05/fellowship_groupsshot.jpg?itok=3vDGsi8m 40w, https://www.columbiacardiology.org/sites/default/files/styles/cola_media_200_21_9/public/media/images/2018-05/fellowship_groupsshot.jpg?itok=2904mxop 200w, https://www.columbiacardiology.org/sites/default/files/styles/cola_media_260_21_9/public/media/images/2018-05/fellowship_groupsshot.jpg?itok=0OkK0IZ4 260w, https://www.columbiacardiology.org/sites/default/files/styles/cola_media_320_21_9/public/media/images/2018-05/fellowship_groupsshot.jpg?itok=fF2DNNkc 320w, https://www.columbiacardiology.org/sites/default/files/styles/cola_media_400_21_9/public/media/images/2018-05/fellowship_groupsshot.jpg?itok=aizIjGYu 400w, 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pane-node-field-lab-location classy-panel-styles pane cb-style--auto cb-style cb-lab-location" > <h2 class="pane-title"> Location and Contact Information </h2> <div class="paragraphs-items paragraphs-items-field-lab-location paragraphs-items-field-lab-location-full paragraphs-items-full"> <div class="field field-name-field-lab-location field-type-paragraphs field-label-hidden"><div class="entity entity-paragraphs-item paragraphs-item-contact-information cw-with-map cb-contact-information"> <div class="content"> <div class="field field-name-field-contact-info-address field-type-addressfield field-label-hidden cb-contact-information__address"><div class="field-items"><div class="field-item odd"><div class="street-block"><div class="thoroughfare">630 West 168th Street</div> <div class="premise">Physicians and Surgeons Building, 8-510</div></div> <div class="addressfield-container-inline locality-block country-US"><span class="locality">New York</span>, <span class="state">NY</span> <span class="postal-code">10032</span></div> <span class="country">United States</span></div></div></div> <div class="paragraphs-items paragraphs-items-field-phone-paragraphs paragraphs-items-field-phone-paragraphs-full paragraphs-items-full cb-phone cb-contact-information__phone"> <ul class="field field-name-field-phone-paragraphs field-type-paragraphs field-label-hidden"><li class="field-item odd first last"><div class="entity entity-paragraphs-item paragraphs-item-phone"> <div class="content"> <a href="tel:2123059370" class="phone-link" aria-label="Phone">212-305-9370</a> </div> </div> </li></ul></div> <div class="field field-name-field-contact-info-geolocation field-type-geofield field-label-hidden cb-contact-information__map"><a href="http://maps.google.com/?q=40.840954900000,-73.941459000000" target="_blank"><span class="element-invisible">Open location in Google Maps</span><img src="https://www.columbiacardiology.org/sites/default/files/staticmaps/paragraphs_item-69621-1161101fc35a455b1095a67dbd7d4a0fe3d1.png" width="600" height="450" alt="" /></a></div> </div> </div> </div></div> </div> <div class="panel-pane pane-entity-field pane-node-field-lab-principal-investigator classy-panel-styles pane cb-style--auto cb-style cb-list-profiles--lab-heads cb-list-profiles" > <h2 class="pane-title"> Principal Investigator </h2> <div class="field field-name-field-lab-principal-investigator field-type-paragraphs field-label-hidden cb-list-profiles__content"><div class="entity entity-paragraphs-item paragraphs-item-cola-cups-profiles"> <ul class="field field-name-field-cola-cups-profiles field-type-entityreference field-label-hidden"><li class="field-item odd first last"> <div class="panelizer-view-mode node node-teaser node-cups-profile node-1592"> <div class="cb-panel-container"> <div class="panel-pane pane-node-title cb-list-profiles__title" > <h3><a href="/profile/emily-j-tsai-md">Emily J. Tsai, MD</a></h3> </div> <div class="panel-pane pane-entity-field pane-node-field-cups-headshot cb-list-profiles__headshot" > <div class="field field-name-field-cups-headshot field-type-image field-label-hidden"><div class="field-items"><div class="field-item odd"><img class="lazyload" src="data:image/jpeg;base64,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" data-srcset="https://www.columbiacardiology.org/sites/default/files/styles/cola_media_200/public/cups-profile/headshot/214a07f0-e39a-11ea-a22f-d385b4d8c094.jpg?itok=6CHQUnj7 200w, https://www.columbiacardiology.org/sites/default/files/styles/cola_media_260/public/cups-profile/headshot/214a07f0-e39a-11ea-a22f-d385b4d8c094.jpg?itok=YelBNGNF 260w, https://www.columbiacardiology.org/sites/default/files/styles/cola_media_320/public/cups-profile/headshot/214a07f0-e39a-11ea-a22f-d385b4d8c094.jpg?itok=dAIGDkk8 320w, https://www.columbiacardiology.org/sites/default/files/styles/cola_media_400/public/cups-profile/headshot/214a07f0-e39a-11ea-a22f-d385b4d8c094.jpg?itok=gmJXngns 400w, https://www.columbiacardiology.org/sites/default/files/styles/cola_media_520/public/cups-profile/headshot/214a07f0-e39a-11ea-a22f-d385b4d8c094.jpg?itok=PBObmZjJ 520w, https://www.columbiacardiology.org/sites/default/files/styles/cola_media_640/public/cups-profile/headshot/214a07f0-e39a-11ea-a22f-d385b4d8c094.jpg?itok=YvjV5kmr 640w, https://www.columbiacardiology.org/sites/default/files/styles/cola_media_800/public/cups-profile/headshot/214a07f0-e39a-11ea-a22f-d385b4d8c094.jpg?itok=b0nMRLiT 800w" alt="Profile Headshot" title="Emily J. Tsai, MD" sizes="auto" /></div></div></div> </div> </div> </div> </li></ul></div> </div> </div> <div class="panel-pane pane-entity-field pane-node-body" > <div class="field field-name-body field-type-text-with-summary field-label-hidden"> <p>The Tsai Lab focuses on discovering and understanding novel signaling mechanisms of heart failure and developing innovative therapies for improving heart function. We utilize multidisciplinary approaches ranging from discovery science in patient biological samples to mechanistic studies in cell-based systems, transgenic mice, and animal models of heart failure. Two major active areas of research for the Tsai Lab are: 1) elucidating the cardioprotective mechanisms of nitric oxide receptor soluble guanylyl cyclase (GC1) across distinct subcellular microdomains within heart cells; and 2) characterizing the molecular pathophysiology that uniquely underlies right ventricular dysfunction and right heart failure.</p> <p>The ultimate goal of the Tsai Lab is to discover novel approaches for treating patient with chronic heart failure, particularly those who are already optimized on guideline directed medical therapy. Our major emphasis is in preventing and reversing right ventricular failure, an unmet, morbid and fatal, clinical need.</p> <p>聽</p> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </main> <footer class="cb-site-footer" role="contentinfo" aria-label="Division of Cardiology"> <div class="cb-container cb-local-footer"> <div class="cb-container__inner"> <div class="panel-pane pane-panels-mini pane-cola-panels-affiliates" > <div class="cb-panel-container"> <div class="panel-pane pane-paragraph-panes pane-link" > <span class="field field-name-field-link-link field-type-link-field field-label-hidden"><a href="https://www.cuimc.columbia.edu" target="_blank" class="logo-cumc" rel="nofollow">Columbia University Irving Medical Center</a></span> </div> <div class="panel-pane pane-paragraph-panes pane-link" > <span class="field field-name-field-link-link field-type-link-field field-label-hidden"><a href="https://www.nyp.org" target="_blank" class="logo-nyp" 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