CINXE.COM

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<div class="ra_toggle btn btn-tertiary">Back to Research Areas </div> </div> <div class="ra_menu_block"> <div class="et-researchareas-research-topics ra_menu_items"> <div class="et-researchareas-topic-block"> <h5 class="et-researchareas-topic-title">Categories Menu</h5> <ul class="et-researchareas-topic-ul" data-count="12" id="menuResearchAreas"> <li class="et-researchareas-topic-li " id="cancer"> <a href="/research-area/cancer"> <span class="icon-cancer"> Cancer </span> </a> </li> <li class="et-researchareas-topic-li " id="cardiovascularbiology"> <a href="/research-area/cardiovascular-biology"> <span class="icon-cardiovascularbiology"> Cardiovascular Biology </span> </a> </li> <li class="et-researchareas-topic-li " id="cytokinesandgrowthfactors"> <a href="/research-area/cytokines-and-growth-factors"> <span class="icon-cytokinesandgrowthfactors"> Cytokines and Growth Factors </span> </a> </li> <li class="et-researchareas-topic-li " id="developmentalbiology"> <a 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for the study of protein synthesis and translational regulation. We offer products for eIFs, heterotrimeric initiation complexes that form on the ribosome during protein synthesis. Each eIF serves a distinct function during protein synthesis to help attach, assemble, and drive the ribosome along the mRNA. Studies show that eIF activity plays an important role in cell cycle progression, tumorigenesis, embryonic development, nuclear export, and synaptic plasticity. In addition, we offer products targeting other molecules that are involved in the initiation (4EBP1) and inhibition of protein synthesis (MBD-3, PERK).</p> </div> <div class="et-researchareas-children bullet_tile_parent"> <ul> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">4EBP1</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/4ebp1">4EBP1</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">eEF-2</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/eef-2">eEF-2</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">Eukaryotic Initiation Factors (eIF)</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/eif2-alpha">eIF2 alpha</a></li> <li><a href="/target/eif4b">eIF4B</a></li> <li><a href="/target/eif4e">eIF4E</a></li> <li><a href="/target/eif4g1">eIF4G1</a></li> <li><a href="/target/eif5a">eIF5A</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">GCN2</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/gcn2">GCN2</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">p70 S6 Kinase beta</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/p70-s6-kinase">p70 S6 Kinase</a></li> <li><a href="/target/p70-s6-kinase-beta">p70 S6 Kinase beta</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">PERK/EIF2AK3</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/perk">PERK</a></li> <li><a href="/target/perk-inhibitors">PERK Inhibitors</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">Ribosomal Protein S6 Kinases (RSK)</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/rsk">RSK</a></li> <li><a href="/target/rsk1-rsk2">RSK1/RSK2</a></li> <li><a href="/target/rsk-inhibitors">RSK Inhibitors</a></li> <li><a href="/target/rsk1">RSK1</a></li> <li><a href="/target/rsk2">RSK2</a></li> <li><a href="/target/rsk3">RSK3</a></li> <li><a href="/target/rsk4">RSK4</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">Ribosomal Proteins</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/ribosomal-protein-l17">Ribosomal Protein L17</a></li> <li><a href="/target/ribosomal-protein-s6-rps6">Ribosomal Protein S6/RPS6</a></li> </ul> </div> </li> <li class="et-researchareas-children-li"> <div class="et-researchareas-molecule-block"> <h3 class="et-researchareas-molecule-title">Other Translational Regulators</h3> <ul class="et-researchareas-molecule-ul"> <li><a href="/target/irak3">IRAK3</a></li> <li><a href="/target/irak4">IRAK4</a></li> <li><a href="/target/lin-28a">LIN-28A</a></li> <li><a href="/target/mbd3">MBD3</a></li> <li><a href="/target/mcpip1">MCPIP1</a></li> <li><a href="/target/pdcd4">PDCD4</a></li> <li><a href="/target/pdcd5">PDCD5</a></li> <li><a href="/target/pum1">PUM1</a></li> <li><a href="/target/pum2">PUM2</a></li> </ul> </div> </li> </ul> </div> <div class="ra_menu_block"> <div class="et-researchareas-related-info ra_related_info ra_menu_items"> <div class="et-researchareas-related-info-block"> <h2 class="et-researchareas-related-info-title">Related Information</h2> <ul class="et-researchareas-related-info-ul" data-count="1" id="relatedInformation"> <li 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