ExplorEnz: EC 6.2.1.35

<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.0//EN" "http://www.w3.org/TR/REC-html40/strict.dtd"> <html> <head> <title>ExplorEnz: EC 6.2.1.35</title> <meta http-equiv="Content-Type" content="text/html; charset=iso-8859-1" /> <meta name="keywords" content="EC 6.2.1.35,ExplorEnz,IUBMB,Enzyme Nomenclature Database,Enzyme Classification" /> <meta name="description" content="Enzyme Nomenclature Database" /> <meta name="robots" content="index,nofollow"> <meta name="googlebot" content="index,nofollow" /> <link rel="stylesheet" type="text/css" href="enzyme2.css"> <link rel="shortcut icon" href="favicon.ico" /> <style type="text/css" media="screen">  </style> </head> <base href="//query.php?ec=6.2.1.35"> <body> <a href="index.php"> <img src="images/banner_5.gif" alt="The Enzyme Database" width="920 px" height="" border="0" /></a> </div><table border="0" cellborder="0" cellspacing="0" cellpadding="0" width="100%" id="nav"> <tr> <td class="f" nowrap="nowrap" colspan="1" border="0"> <li><a href="./" alt="Home" title="Home">Home</a></li> <li><a href="search.php" alt="Simple Search" title="Search the database">Search</a></li> <li><a href="class.php" alt="Enzyme Classes" title="Hierarchical view of the Enzyme Classification system">Enzymes by Class</a></li> <li><a href="newenz.php" alt="New/Modified Enzymes" title="New/modified enzyme entries">New/Amended Enzymes</a></li> <li><a href="stats.php" alt="Enzyme Count" title="Enzyme count">Statistics</a></li> <li><a href="forms.php" alt="Forms" title="Submit data on a new enzyme, or report an error">Forms</a></li> <li><a href="news.php" alt="News" title="Reports on recent developments in enzyme classification or changes to nomenclature">News</a></li> <li><a href="about.php" alt="Help Files, Archives" title="Quick-start Guide, FAQ, Supplements">Information</a></li> <li><a href="downloads.php" alt="Downloads" title="Download the database">Downloads</a></li> <li></li> </td> </tr> </table> Your query returned 1 entry.    <a href="query.php?ec=6.2.1.35&pr=on" target="new"><img src="images/print.png" alt="printer_icon" align="center" border="0"></a>Printable version <table border="0" cellpadding="2" cellspacing="3" width="100%"> <tr valign="bottom"> <td width="20%" align="right"><a name="1"></a>EC</td> <td width="80%" colspan="1">6.2.1.35     </td> </tr> <tr> <td width="20%" align="right">Accepted name:</td> <td width="80%" colspan="1">acetate—[acyl-carrier protein] ligase</td> </tr> <tr> <td width="20%" align="right">Reaction:</td> <td width="80%" colspan="1">ATP + acetate + an [acyl-carrier protein] = AMP + diphosphate + an acetyl-[acyl-carrier protein]</td> </tr> <tr> <td width="20%" align="right"></td> <td width="80%">For diagram of malonate decarboxylase, <a target="new" href="reaction/misc/maldecarb.html">click here</a></td> </tr> <tr> <td width="20%" align="right">Other name(s):</td> <td width="80%" colspan="1">HS-acyl-carrier protein:acetate ligase; [acyl-carrier protein]:acetate ligase; MadH; ACP-SH:acetate ligase</td> </tr> <tr valign="top"> <td width="20%" align="right">Systematic name: </td> <td width="80%" colspan="1">acetate:[acyl-carrier-protein] ligase (AMP-forming)</td> </tr> <tr valign="top"> <td width="20%" align="right">Comments:</td> <td width="80%" colspan="1">This enzyme, from the anaerobic bacterium Malonomonas rubra, is a component of the multienzyme complex <a href="query.php?ec=7.2.4.4" target="new">EC 7.2.4.4</a>, biotin-dependent malonate decarboxylase. The enzyme uses the energy from hydrolysis of ATP to convert the thiol group of the acyl-carrier-protein-bound 2′-(5-phosphoribosyl)-3′-dephospho-CoA cofactor into its acetyl thioester [2].</td> </tr> <tr> <td width="20%" align="right">Links to other databases:</td> <td width="80%" colspan="1"><a href="https://www.brenda-enzymes.org/enzyme.php?ecno=6.2.1.35" target="new">BRENDA</a>, <a href="https://enzyme.expasy.org/EC/6.2.1.35" target="new">EXPASY</a>, <a href="https://www.kegg.jp/dbget-bin/www_bget?ec:6.2.1.35" target="new">KEGG</a>, <a href="http://biocyc.org/META/NEW-IMAGE?type=EC-NUMBER&object=EC-6.2.1.35" target="new">MetaCyc</a></td> </tr> <tr> <td width="20%" align="right" valign="top">References:</td> <td align="left" valign="top" colspan="1"> <table border="0" cellpadding="0"><tr> <td>1. </td> <td>Hilbi, H., Dehning, I., Schink, B. and Dimroth, P. Malonate decarboxylase of Malonomonas rubra, a novel type of biotin-containing acetyl enzyme. Eur. J. Biochem. 207 (1992) 117–123. [<a href="https://doi.org/10.1111/j.1432-1033.1992.tb17028.x" target="new">DOI</a>] [PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/1628643" target="new">1628643</a>] </td> </tr> </td></tr> <tr> <td>2. </td> <td>Berg, M., Hilbi, H. and Dimroth, P. The acyl carrier protein of malonate decarboxylase of Malonomonas rubra contains 2′-(5"-phosphoribosyl)-3′-dephosphocoenzyme A as a prosthetic group. Biochemistry 35 (1996) 4689–4696. [<a href="https://doi.org/10.1021/bi952873p" target="new">DOI</a>] [PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/8664258" target="new">8664258</a>] </td> </tr> </td></tr> <tr> <td>3. </td> <td>Berg, M., Hilbi, H. and Dimroth, P. Sequence of a gene cluster from Malonomonas rubra encoding components of the malonate decarboxylase Na+ pump and evidence for their function. Eur. J. Biochem. 245 (1997) 103–115. [<a href="https://doi.org/10.1111/j.1432-1033.1997.00103.x" target="new">DOI</a>] [PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/9128730" target="new">9128730</a>] </td> </tr> </td></tr> <tr> <td>4. </td> <td>Dimroth, P. and Hilbi, H. Enzymic and genetic basis for bacterial growth on malonate. Mol. Microbiol. 25 (1997) 3–10. [<a href="https://doi.org/10.1046/j.1365-2958.1997.4611824.x" target="new">DOI</a>] [PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/11902724" target="new">11902724</a>] </td> </tr> </td></tr> </table></td></tr> </td></tr> <tr><td colspan="2"><center>[EC 6.2.1.35 created 2008, modified 2018]</center></td> </tr> <tr> <td> </td> <td></td> </tr> <tr> <td> </td> <td></td> </tr> </table> <center>Data © 2001–2025 IUBMB Web site © 2005–2025 Andrew McDonald </center> </body> </html>

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ExplorEnz: EC 6.2.1.35