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as a Method * define function as object methods * @type {Object} */ window.digitalData = { user: {}, page: {}, merchandising: {}, getQueryParam : function (param) { var index, key, value, hash; var hashes = window.location.href.slice(window.location.href.indexOf('?') + 1).split('&'); for (index = 0; index < hashes.length; index++) { hash = hashes[index].split('='); key = hash[0]; value = hash[1]; if (key.toUpperCase() === param.toUpperCase()) return value; } return ''; }, getValOnce: function (value, cookieName, expiry, timeUnit) { var currentDate = new Date; var currentCookieValue; // timeUnit of 'm' is minutes represented in milliseconds // thus 86400000 = 24 hours = 1 day var interval = timeUnit == 'm' ? 60000 : 86400000; cookieName = cookieName ? cookieName : 'digitaldata_gvo'; value = value ? value : ''; expiry = expiry ? expiry : 0; currentCookieValue = this.getCookie(cookieName); if (value) { currentDate.setTime(currentDate.getTime() + expiry * interval); this.setCookie(cookieName, value, expiry == 0 ? 0 : currentDate); } return value == currentCookieValue ? '' : value; }, getCookie: function (key) { var result = ""; var cookies = document.cookie ? document.cookie.split('; ') : []; for (var i = 0; i < cookies.length; i++) { var parts = cookies[i].split('='); var name = decodeURIComponent(parts.shift()); var cookie = parts ? parts.join('=') : []; // Prevent storing or parsing of a cookie that we couldn't decode. if (cookie && key === name) { // removes surrounding quotes if (cookie.indexOf('"') === 0) { // This is a quoted cookie as according to RFC2068, unescape... cookie = cookie.slice(1, -1).replace(/\\"/g, '"').replace(/\\\\/g, '\\'); } // parse utf8 characters try { cookie = decodeURIComponent(cookie); } catch (e) {} result = cookie; // we found it, don't bother looking at other cookies break; } } return result; }, setCookie : function(name, value, numDays){ if ( !numDays ) numDays = 31; var expires = new Date(); expires.setTime(expires.getTime() + (1000 * 60 * 60 * 24 * numDays)); document.cookie = name+ '=' + escape(value) + '; path=/; expires=' + expires.toGMTString() + '; domain=.' + this.getMasterDomain() + ';'; }, /** * get the master domain based on business rules */ getMasterDomain : function () { // default the master domain var masterDomain = 'thermofisher.com'; // check for alternate domain portion of URL var regexMatch = document.location.hostname.match(/\.(thermofisher)\.(cn)/i); if (regexMatch !== null) { masterDomain = regexMatch[1] + '.' + regexMatch[2]; } return masterDomain; }, /** * Check if init has been initiated once * @type {Boolean} */ initted: false, /** * @return {Array} method returns an array of a given object's key properties */ init: function () { this.page.country = this.getCookie("CK_ISO_CODE") || 'us'; this.page.language = this.getCookie('CK_LANG_CODE') || 'en'; this.page.siteName = 'thermo'; //hard coded this.initMerchandisingData(); this.initUserData(); this.displayDigitalData(); this.formSubmitEvent(); }, //specific function to set type of the page // need specific function to keep page type separate from other page attributes setPageType: function (type) { this.setPageAttribute('type', type); }, // generic function to set page attributes setPageAttribute: function (key, value) { this.page[key] = value; }, // display digitalData object displayDigitalData: function () { }, // specific function to add an object to digitalData addDigitDataObject: function (key, object) { this[key] = object; }, addChildObjectAttribute: function(child, key, value){ this[child][key] = value; }, initUserData: function(){ var gigyaCookie = this.getCookie("identity_uid"); this.user.gigyaId = ""; this.user.loginStatus = "anonymous"; if( gigyaCookie != ""){ this.user.gigyaId = gigyaCookie; this.user.loginStatus = "logged in"; } }, /** * Check if init has been initiated once * @type {Boolean} */ merchandisingDataInitted: false, initMerchandisingData: function () { // read cid and icid value from session cookie this.merchandising.icid = this.getCookie('s_ev21_tc'); this.merchandising.cid = this.getCookie('s_cmp_tc'); // EMID value this.merchandising.emid = this.getQueryParam("emid"); // referrer by domain if (typeof document.referrer !== 'undefined' && document.referrer.length > 0) { var masterDomain = this.getMasterDomain(); var refReg = document.referrer; var referrerDomain = refReg.match(/:\/\/([^/]+)\//); if (referrerDomain !== null && referrerDomain[1].indexOf(masterDomain) == -1) { this.merchandising.referrer = referrerDomain; } } document.addEventListener('registerMerchandisingData', function (event) { for (var key in event.detail) { console.log("Listener data copied", key, event.detail[key] ); digitalData.merchandising[key] = event.detail[key]; } // Map some analytics attributes to merchandising session attributes digitalData.merchandising.sessionId = digitalData.merchandising.analyticsVisitorID; digitalData.merchandising.s_vi_low = digitalData.merchandising.analyticsVisitorIDLow; digitalData.merchandising.s_vi_high = digitalData.merchandising.analyticsVisitorIDHigh; console.log("digitalData: Captured registerMerchandisingData event"); digitalData.merchandisingDataInitted = true; // Call emailCampaignRecord if the digitalDataAnalyticsListener object is loaded if (typeof digitalDataAnalyticsListener != "undefined") { console.log("digitalData: Calling email campaign record"); digitalDataAnalyticsListener.emailCampaignRecord(); } }); }, formSubmitEvent: function () { var formId = this.getQueryParam("form-submit-id"); if ((formId) && formId !== "" && formId !== null) { var eventDetail = { detail: { form: { id: formId } } }; var formSubmitEvent = new CustomEvent('formSubmit', eventDetail); console.log('form submit event started'); document.dispatchEvent(formSubmitEvent); console.log('form submit event fired', eventDetail); //flush grepToken from Session Storage sessionStorage.removeItem('grepTokenSO'); } }, modalVideoEvent: function (videoId) { if (((videoId) && videoId !== "" && videoId !== null)) { var eventDetail = { detail: { video: { playerId: videoId } } }; var modalVideoEvent = new CustomEvent('videoPlayerLoaded', eventDetail); document.dispatchEvent(modalVideoEvent); } }, customClickEvent: function (clickDetail) { if (((clickDetail) && clickDetail !== "" && clickDetail !== null)) { var eventDetail = { detail: { CustomLink: { linkName: clickDetail } } } var customClickEvent = new CustomEvent('customLinkClicks', eventDetail); document.dispatchEvent(customClickEvent); } } } })(); window.digitalData.init(); </script>  <script type="text/javascript"> window.performance && window.performance.mark && window.performance.mark("header_25"); </script> <script type="text/javascript"> var localizedStrings = { "ACCEPTANCE": "Acceptance of Terms of Use", "BTN_AGREE": "Agree", "BTN_DISAGREE": "Disagree", "PROCESSING_MESSAGE" :"processing ... please wait ...", "ADD_TO_CART_QUANTITY_ERROR":"You must provide a quantity to add an item to the cart", "ADD_TO_CART_VALID_QUANTITY_ERROR":"You must provide a valid quantity to add an item to the cart", "VIEW_CART" :"View cart & checkout", "VIEW_CONTACT_DETAIL" :"View Contact Details", "ADD_TO_CART_NOTIFICATION":"Add to Cart Notification", "UPDATE_CART" :"Update Cart", "PRINCIPAL_INVESTIGATOR":"Principal Investigator", "PRINCIPAL_INVESTIGATOR_TEAM_LEADER":"Principal Investigator or Team Leader", "PRINCIPAL_INVESTIGATOR_CHIEF":"Principal Investigator or Chief", "EMAIL_ERROR_1" :"Please Provide Collegues Email", "EMAIL_ERROR_2" :"Please enter a valid colleague email address", "EMAIL_ERROR_3" :"Please Provide Your Email", "EMAIL_ERROR_4" :"Please enter a valid email address", "ERROR_OCCURED_MESSAGE" :"The following errors occured", "NEXT" :"Next", "PREVIOUS" :"Prev", "IMAGE" :"Image", "SAVE_TO_LIST_ERROR_1" :"Please enter a list name.", "SAVE_TO_LIST_ERROR_2" :"Please enter a different list name that does not include the following: ?,/,\\,%,^,!", "MINICART_ERROR_1" :"Unable to connect to eCommerce system. 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APC, eBioscience™</h1> <div class="details-hero" ng-click="$ctrl.toggleImages('ADVANCED_VERIFICATION')"> <a class="link adv-verification-link animated-scroll" href="/sg/en/home/life-science/antibodies/invitrogen-antibody-validation.html"> <svg class="svg-icon advanced-verification-icon"> <use href="#icon-advanced-verification"></use> </svg> Advanced Verification </a> <p class="adv-verification-detail" onclick="window.THERMO_FISHER.pdp.inp.toggleImagesAdvVerificationSmLtr(event, this)"> This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. </p> </div> <div class="details-hero" onclick="window.THERMO_FISHER.pdp.inp.toggleImagesAdvVerificationPublishedFigures(event, this)"> <a class="link published-link animated-scroll " href="#image-gallery" onclick="window.THERMO_FISHER.pdp.inp.publishedFiguresHero(event, this)"> <svg class="svg-icon published-figures-icon"> <use href="#icon-published-figures"></use> </svg> 73 Published Figures </a> </div> <div class="details-hero"> <a class="link references-link animated-scroll " href="#references-component-id" onclick="window.THERMO_FISHER.pdp.inp.referencesHero(event, this)"> <svg class="svg-icon references-icon"> <use href="#icon-references"></use> </svg> 194 References </a> </div> <div class="details-hero"> <a class="btn hero-btn hero-view-other" href="/antibody/primary/target/b220 (cd45r)"> View all (96) B220 (CD45R) antibodies </a> </div> </div> <div class="links-ab to-show-links-in-sm"> <div class="container"> <div class="link-container"> <a class="link-antibody" href="/order/genome-database/dataSheetPdf?producttype=antibody&productsubtype=antibody_primary&productId=17-0452-82&version=Local" target="_blank" rel="nofollow"> <span> <svg class="svg-icon data-sheet-icon"> <use href="#icon-data-sheet"></use> </svg> </span> Datasheet </a> </div> <div class="link-container"> <a 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(a-c) Flow cytometry gating strategy for the identification of CD45+ myeloid (lin-) and lymphoid (lin+) cells, neutrophils (CD45+, lin-, Ly6G+), and macrophages (CD45+, lin-, F4/80+, CD11b+) in the aged spleen. (b) Comparison of the ratio of myeloid cells to lymphoid cells in the spleen of saline and PF4 treated aged mice (n \u003d 8 saline; 9 PF4 mice). (c) Comparison of the relative populations of neutrophils and macrophages in the spleen (n \u003d 8 saline; 9 PF4 mice). (d) qPCR of inflammation-related genes relative to Gapdh in the aged spleen (n \u003d 12 saline; 11 PF4 mice). (e-f) Flow cytometry gating strategy for the identification of CD4+ T cells, CD8+ T cells, and CD8+ T effector memory cells (CD45+, CD3+, CD8+, CD44 HI , CD62L LO) in the aged spleen. (f) Comparison of the relative populations of T cells in the spleen (n \u003d 8 mice/group). (g) Schematic of aged T cell isolation, activation, and treatment with vehicle or PF4 (1 mug mL -1). 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(b) Comparison of the ratio of myeloid cells to lymphoid cells in the spleen of saline and PF4 tre... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Aug 1, 2023, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature','journalText':'Nature 2023 - ','sourceType':'3','benchsci':true,'imageName':'tfs_29067_41586_2023_6436_Fig10_ESM.jpg','benchSciPubmedId':'37587343'},{'sku':'17-0452-82','imageId':'988480','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_24533_41419_2022_5171_Fig7_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_24533_41419_2022_5171_Fig7_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_24533_41419_2022_5171_Fig7_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_24533_41419_2022_5171_Fig7_HTML.jpg?time\u003d20240507','sortOrder':'5','description':'Lenvatinib insignificantly affects the immune microenvironment in NPC in humanized NSG mice. A Schematic diagram of the establishment of humanized NSG mice. B Representative FACS analysis of human CD45 + cells in mouse peripheral blood. Human CD45 + cell percentage greater than 25% was considered successful in modeling. C - E Tumor growth ( C ), tumor weights ( D ) were measured in vehicle-, anti-VEGF-, and lenvatinib-treated NPC tumors. The tumor inhibition ratio were calculated ( E ) ( n \u003d 3 samples per group). F Representative micrographs of Ki67 + proliferative cells and cleaved caspase-3 + apoptotic cells in vehicle-, anti-VEGF-, and lenvatinib-treated NPC tumors. Scale bar \u003d 50 mum. Quantification of Ki67 + , cleaved caspase-3 + signals, and PA index in vehicle-, anti-VEGF-, and lenvatinib-treated NPC tumors. ( n \u003d 8 random fields per group) G Representative micrographs of CD31 + microvessels and CA9 + hypoxic areas in vehicle-, anti-VEGF-, and lenvatinib-treated NPC tumors. Scale bar in upper panel \u003d 100 mum, scale bar in lower panel \u003d 50 mum. Quantification of CD31 + tumor vessel parameters and CA9 + signals in vehicle-, anti-VEGF-, and lenvatinib-treated NPC tumors ( n \u003d 8 random fields per group). H Quantification of hCD45 + hCD14 + population, hCD45 + hCD19 + population, hCD45 + hCD3 + population, and hCD45 + hCD56 + population in the NPC TME ( n \u003d 3 samples per group). I Quantification of mCD45 + mCD11b + mF4/80 + population, mCD45 + mB220 + population, mCD45 + mC','shortDescription':'Lenvatinib insignificantly affects the immune microenvironment in NPC in humanized NSG mice. A Schematic diagram of the establishment of humanized NSG mice. B Representative FACS analysis of human CD45 + cells in mouse peripheral blood. Human CD45 + cell percentage greater than 25% was considered successful in modeling. C - E Tumor growth ( C ), tumor weights ( D ) were measured in vehicle-, anti-VEGF-, and... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Aug 19, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell death \u0026 disease','journalText':'Cell death \u0026 disease 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_24533_41419_2022_5171_Fig7_HTML.jpg','benchSciPubmedId':'35985991'},{'sku':'17-0452-82','imageId':'952779','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_20588_jciinsight-7-150323-g047.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_20588_jciinsight-7-150323-g047.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_20588_jciinsight-7-150323-g047.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_20588_jciinsight-7-150323-g047.jpg?time\u003d20240507','sortOrder':'6','description':'Figure 6 MALP ablation blocks bone marrow recovery after radiation. ( A ) Representative fluorescence images of Td + cells, Perilipin + LiLAs, and CD45 + hematopoietic cells in femoral bone marrow of Adipoq/Td/DTR mice after receiving 2 weeks of vehicle (Veh) or DT injections with or without prior radiation. Scale bar: 20 mum (top), 100 mum (middle), and 20 mum (bottom). ( B ) Quantification of CD45 + cells per bone marrow area. n \u003d 3-6 mice/group. ( C ) Bone marrow cells were flushed from femurs and counted. n \u003d 3-8 mice/group. ( D ) Cell counts of hematopoietic lineage cells in the bone marrow. n \u003d 3-11 mice/group. B cells \u003d B220 + , T cells \u003d CD3 + , myeloid cells \u003d Gr1 + and/or Mac1 + . ( E ) Cell counts of HSPCs. n \u003d 3-11 mice/group. LK, Lineage - cKit + , LSK, Lineage - Sca1 + cKit + , SLAM LSK, Lineage - Sca1 + cKit + CD48 - CD150 + , MPP, Lineage - Sca1 + cKit + CD48 + CD150 - . ( F ) Representative fluorescence images of Adipoq/Td/DTR femoral bone marrow with Emcn staining (vessels). Arrows point to Td + pericytes. Scale bar: 20 mum. ( G ) Quantification of bone marrow vessel diameter, density, and area. ( H ) The number of pericytes per vessel length (VL) was measured. n \u003d 3-4 mice/group. ( I ) The percentage of Emcn + endothelial cells in bone marrow was measured by flow cytometry. n \u003d 3-4 mice/group. ( J ) qRT-PCR analysis of hematopoietic and angiogenic factors in sorted Td - and Td + cells from bone marrow before and after radiation. n \u003d 4 mice/group. Statistica','shortDescription':'Figure 6 MALP ablation blocks bone marrow recovery after radiation. ( A ) Representative fluorescence images of Td + cells, Perilipin + LiLAs, and CD45 + hematopoietic cells in femoral bone marrow of Adipoq/Td/DTR mice after receiving 2 weeks of vehicle (Veh) or DT injections with or without prior radiation. Scale bar: 20 mum (top), 100 mum (middle), and 20 mum (bottom). ( B ) Quantification of CD45 + cells... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Apr 8, 2022, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'JCI insight','journalText':'JCI insight 2022 - ','sourceType':'3','benchsci':true,'imageName':'tfs_20588_jciinsight-7-150323-g047.jpg','benchSciPubmedId':'35393948'},{'sku':'17-0452-82','imageId':'933673','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15202_gr2.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15202_gr2.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15202_gr2.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15202_gr2.jpg?time\u003d20240507','sortOrder':'7','description':'Fig. 2 Generating immuno-CRISPR (iCR) mice and evaluating the CRISPR-mediated modifications by sequencing. ( A ) Model describing the experimental setup where CD45.1 + Lin- BM cells were modified by CRISPR targeting Zap70 and grafted into irradiated CD45.2 + recipients. ( B ) Flow cytometry analysis of cells in the blood of Zap70 iCR mice and WT control mice eight weeks post transplantation. Cells gated on viable, CD45.1+, single lymphocytes. ( C ) Quantification of B and T cells in the blood of WT and Zap70 iCR mice in (B). ( D ) Analysis of the level of mutations in the sgRNA targeted Zap70 region in the BM cells used for transplantation, total cells from the blood, as well as in B and T cells sorted from the spleen of Zap70 iCR mice and WT control mice 8 weeks after engraftment. ( E ) Model describing the experimental setup where a secondary transplantation was used to amplify the population of successfully modified mice. ( F ) Analysis of the level of mutations in the sgRNA targeted GFP region in blood cells of the GFP iCR mice four weeks after transplantation, in an experiment with low efficiency. One mouse showed good knockout efficiency (labeled in orange) and was used as BM donor for secondary transplantation. ( G ) Kinetics of the level of mutations of GFP in the secondary iCR mice. ( H ) As examples, representative flow cytometry plots and ( I ) GFP + cell population percentage of alveolar macrophages, B1 cells, neutrophils and germinal center B cells from secondary','shortDescription':'Fig. 2 Generating immuno-CRISPR (iCR) mice and evaluating the CRISPR-mediated modifications by sequencing. ( A ) Model describing the experimental setup where CD45.1 + Lin- BM cells were modified by CRISPR targeting Zap70 and grafted into irradiated CD45.2 + recipients. ( B ) Flow cytometry analysis of cells in the blood of Zap70 iCR mice and WT control mice eight weeks post transplantation. Cells gated on ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Nov 10, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Computational and structural biotechnology journal','journalText':'Computational and structural biotechnology journal 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15202_gr2.jpg','benchSciPubmedId':'34745454'},{'sku':'17-0452-82','imageId':'933700','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19146_elife-70554-fig8.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19146_elife-70554-fig8.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19146_elife-70554-fig8.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19146_elife-70554-fig8.jpg?time\u003d20240507','sortOrder':'8','description':'Figure 8. Increased IL-2 production impairs T follicular helper (Tfh) cell formation and the germinal centre response. Assessment of the Tfh cell and germinal centre response in Il2 cre/+ ; Rosa26 stop-flox-Il2/+ transgenic mice that do not switch off IL-2 production, and Il2 cre/+ ; Rosa26 +/+ control mice 12 days after influenza A infection. Flow cytometric contour plots ( A ) and quantification of the percentage of CXCR5 high PD-1 high Foxp3 - CD4 + Tfh cells in the mediastinal lymph node ( B ) and spleen ( C ). Flow cytometric contour plots ( D ) and quantification of the percentage of Bcl6 + Ki67 + B220 + germinal centre B cells in the mediastinal lymph node ( E ) and spleen ( F ). The height of the bars indicates the median, each symbol represents one mouse, data are pooled from two independent experiments. p-Values calculated between genotype groups by Mann-Whitney U test.','shortDescription':'Figure 8. Increased IL-2 production impairs T follicular helper (Tfh) cell formation and the germinal centre response. Assessment of the Tfh cell and germinal centre response in Il2 cre/+ ; Rosa26 stop-flox-Il2/+ transgenic mice that do not switch off IL-2 production, and Il2 cre/+ ; Rosa26 +/+ control mice 12 days after influenza A infection. Flow cytometric contour plots ( A ) and quantification of the pe... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Nov 2, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'eLife','journalText':'eLife 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19146_elife-70554-fig8.jpg','benchSciPubmedId':'34726156'},{'sku':'17-0452-82','imageId':'933727','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19147_nihms-1750833-f0002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19147_nihms-1750833-f0002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19147_nihms-1750833-f0002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19147_nihms-1750833-f0002.jpg?time\u003d20240507','sortOrder':'9','description':'Fig. 2. Effect of different PVA hydrolysis rates and molecular weights on ex vivo cultured human cord blood CD34 + hematopoietic stem and progenitor cells. a , Human cord blood CD34 + cells were cultured in PVA media and cell numbers were counted at day 14. Three independent experiments were performed with cord blood CD34 + cells derived from different donors. Cell cultures were started from 7 x 10 3 (Exp.1) or 5 x 10 3 (Exp. 2 and 3) CD34 + cells. Mean +- S.D is shown. Statistical significance was calculated using ANOVA followed by Tukey-Kramer; *p \u003c 0.05, **p \u003c 0.01. b , Proliferation of the two different CD34 + cell fractions after 7-day culture in PVA-containing media. Fifty cells were sorted into four wells in a 96-well plate and cell numbers in each well were counted at 7-day. Statistical significance was calculated using ANOVA and Tukey-Kramer. **p \u003c 0.01.','shortDescription':'Fig. 2. Effect of different PVA hydrolysis rates and molecular weights on ex vivo cultured human cord blood CD34 + hematopoietic stem and progenitor cells. a , Human cord blood CD34 + cells were cultured in PVA media and cell numbers were counted at day 14. Three independent experiments were performed with cord blood CD34 + cells derived from different donors. Cell cultures were started from 7 x 10 3 (Exp.1... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Oct 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Stem cell research','journalText':'Stem cell research 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19147_nihms-1750833-f0002.jpg','benchSciPubmedId':'34509158'},{'sku':'17-0452-82','imageId':'933600','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14887_gr6.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14887_gr6.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14887_gr6.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14887_gr6.jpg?time\u003d20240507','sortOrder':'10','description':'Figure 6 Assessments of organ damage and mouse metabolites during HLSA or recovery from HLSA. A , upper left panel , MMP-1, IL-1beta, and CRP levels in plasma had no significant change between the control group, HLSA group, and R-HLSA group. Upper right panel , CK-MB as a marker of heart injury in the plasma had no significant change between the control group, HLSA group, and R-HLSA group. Lower left panel , creatinine and BUN as markers of kidney injury in the plasma slightly increased in the HLSA group and returned to normal level after recovery from HLSA. Lower right panel , AST and ALT as markers of liver injury in the plasma showed no change between the control group, HLSA group, and R-HLSA group. Data were presented as mean +- SD (N \u003d 6; ANOVA: ** p \u003c 0.01). B , upper panel , food consumption and water consumption 3 days before and 3 days after a single ATP-induced HLSA depicted no change. Data were presented as mean +- SD (N \u003d 6; ANOVA: p \u003e 0.05). Lower panel , metabolomics analysis of scores plot from PCA analysis based on 1 H NMR data from the plasma, brain, liver, and kidney of the control group, HLSA group, and R-HLSA group. The PCA score showcased clusters correspond to metabolic patterns in different groups, with each point representing one sample. Circles represent 95% confidence interval for each score in each group (see also Figs. S5-S8 ). C , draining lymph nodes of mice that underwent HLSA once a day for 10 consecutive days were analyzed with FACS. CD44 and','shortDescription':'Figure 6 Assessments of organ damage and mouse metabolites during HLSA or recovery from HLSA. A , upper left panel , MMP-1, IL-1beta, and CRP levels in plasma had no significant change between the control group, HLSA group, and R-HLSA group. Upper right panel , CK-MB as a marker of heart injury in the plasma had no significant change between the control group, HLSA group, and R-HLSA group. Lower left panel ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Oct 1, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'The Journal of biological chemistry','journalText':'The Journal of biological chemistry 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14887_gr6.jpg','benchSciPubmedId':'34487763'},{'sku':'17-0452-82','imageId':'933646','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14912_jciinsight-6-143245-g005.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14912_jciinsight-6-143245-g005.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14912_jciinsight-6-143245-g005.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14912_jciinsight-6-143245-g005.jpg?time\u003d20240507','sortOrder':'11','description':'Figure 5 CD4 surface expression of CD45RB and global glycosylation are altered in SLE123 mice. ( A and B ) Cell surface expression of CD45RB and total CD45 were measured by flow cytometry on CD4 + T cells. SLE123 demonstrated a downregulation of CD45RB on the cell surface as compared with B6 CD4 + T cells. There was no difference in pan-CD45 expression. Quantified in B . ( C ) CD45 is composed of an intracellular region that controls cytoskeletal binding and its phosphatase activity. The extracellular domain is composed of a region with fibronectin repeats that is heavily N-glycosylated. An alternatively spliced region is heavily O-glycosylated, and this region imparts unique functions to each CD45 isoform. Additionally, a sialic acid residue on the B portion of this region is essential for the binding of therapeutic aCD45RB. ( D and E ) We utilized lectins to detect the level of alpha-2,3-linked sialylation (MALII), O-linked glycosylation (Jacalin), and N-linked glycosylation (PHA-L) in CD4 + T cells from B6 and SLE123 mice. We determined SLE123 CD4 + T cells had reduced levels of alpha-2,3-linked sialic acids and O-glycosylation and an increase in N-glycosylation. Quantified in E . ( F ) Utilizing an antibody that detects a desialylated form of anti-CD45RB, we determined SLE123 CD4 + T cells possessed increased binding of this antibody compared with B6. ( G and H ) To determine the binding of therapeutic aCD45RB to B6 and SLE123 CD4 + T cells, we incubated splenocytes from','shortDescription':'Figure 5 CD4 surface expression of CD45RB and global glycosylation are altered in SLE123 mice. ( A and B ) Cell surface expression of CD45RB and total CD45 were measured by flow cytometry on CD4 + T cells. SLE123 demonstrated a downregulation of CD45RB on the cell surface as compared with B6 CD4 + T cells. There was no difference in pan-CD45 expression. Quantified in B . ( C ) CD45 is composed of an intrace... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Oct 8, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'JCI insight','journalText':'JCI insight 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14912_jciinsight-6-143245-g005.jpg','benchSciPubmedId':'34403367'},{'sku':'17-0452-82','imageId':'933573','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_15196_41467_2021_22173_Fig7_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_15196_41467_2021_22173_Fig7_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_15196_41467_2021_22173_Fig7_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_15196_41467_2021_22173_Fig7_HTML.jpg?time\u003d20240507','sortOrder':'12','description':'Fig. 7 Upregulation of PD-L1 by MTHFD2 is required for tumorigenesis. a - b A total of 2 x 10 6 ( a ) or 5 x 10 6 ( b ) Pan02 cells stably infected with lentivirus carrying indicated shRNAs or exogenous expressed PD-L1, were subcutaneously injected into athymic nude mice ( a ) or C57 mice ( b ), tumor volume was calculated every 7 days. Tumor xenografts at the 28th day in nude mice ( a ) or the 21th day in C57 mice ( b ) were shown. Data represent the means +- s.e.m ( n \u003d 8 mice per group); p value (Student\u0027s t test, two-sided) with control is presented. c , PD-L1 mRNA levels in tumor tissues in C57 mice were analyzed by real-time PCR. The values are presented as mean +- s.e.m ( n \u003d 3); p values (Student\u0027s t test, two-sided) with control or the indicated groups are presented. d The lysates of 8 pooled tumor tissues in C57 mice were subjected to immunoblotting analyses using the indicated antibodies. e Immunohistochemical staining was performed on tumor sections in C57 mice with anti-CD8 antibody. Representative images are shown. Scale bars, 50 mum. Histological semi-quantification was performed. f Cells digested from indicate tumor tissues in C57 mice were stained with anti-CD45 antibody and subjected to flow cytometric analyses (also see Supplementary Fig. 7b ). Representative images (1 out of 3 experiments) are shown. g A schematic model showing the role of MTHFD2 in tumor immune evasion. MTHFD2 promotes PD-L1 mediated tumor immune evasion through the folate-cycle-UTP-UDP-G','shortDescription':'Fig. 7 Upregulation of PD-L1 by MTHFD2 is required for tumorigenesis. a - b A total of 2 x 10 6 ( a ) or 5 x 10 6 ( b ) Pan02 cells stably infected with lentivirus carrying indicated shRNAs or exogenous expressed PD-L1, were subcutaneously injected into athymic nude mice ( a ) or C57 mice ( b ), tumor volume was calculated every 7 days. Tumor xenografts at the 28th day in nude mice ( a ) or the 21th day in ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Mar 29, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_15196_41467_2021_22173_Fig7_HTML.jpg','benchSciPubmedId':'33782411'},{'sku':'17-0452-82','imageId':'855412','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_9908_fimmu-11-590266-g001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_9908_fimmu-11-590266-g001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_9908_fimmu-11-590266-g001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_9908_fimmu-11-590266-g001.jpg?time\u003d20240507','sortOrder':'13','description':'Figure 1 Development of myeloid cell populations is not detectably altered in MphCK2alpha -/- mice. (A) Schematic of Csnk2a targeting vector. (B) Immunoblots of lysates from BMDMs, splenocytes, or peritoneal cavity cells of LysM cre or LysM cre CK2alpha fl/fl (MphCK2alpha - / - ) mice were probed for CK2alpha or beta-actin as a loading control. n \u003d 2. (C) Splenic myeloid cell populations were stained and analyzed by flow cytometry. Plots depict gating for representative F4/80+ macrophages, Ly6C+ monocytes, and neutrophils (also Ly6G+). (D) Cells from spleen were stained for flow cytometry to enumerate immune cell populations. Data are from pooled experiments, n \u003d 4-12 mice/group. (E) Cells from bone marrow were stained for flow cytometry to evaluate bone marrow precursor populations including common myeloid progenitors (CMPs), granulocyte-monocyte progenitors (GMPs), and megakaryocyte-erythrocyte progenitor (MEP). Cells were pre-gated on Lin-(B220, CD3, CD11b, GR-1 and TER-119), Sca-1-, cKit-. Density plots are representative from two experiments.','shortDescription':'Figure 1 Development of myeloid cell populations is not detectably altered in MphCK2alpha -/- mice. (A) Schematic of Csnk2a targeting vector. (B) Immunoblots of lysates from BMDMs, splenocytes, or peritoneal cavity cells of LysM cre or LysM cre CK2alpha fl/fl (MphCK2alpha - / - ) mice were probed for CK2alpha or beta-actin as a loading control. n \u003d 2. (C) Splenic myeloid cell populations were stained and an... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Jul 27, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in immunology','journalText':'Frontiers in immunology 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_9908_fimmu-11-590266-g001.jpg','benchSciPubmedId':'33363536'},{'sku':'17-0452-82','imageId':'933546','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_8372_fimmu-11-576310-g0004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_8372_fimmu-11-576310-g0004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_8372_fimmu-11-576310-g0004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_8372_fimmu-11-576310-g0004.jpg?time\u003d20240507','sortOrder':'14','description':'Figure 4 Ptpn6 deletion drives robust anti-tumor immunity in two immune-rich syngeneic tumor lines. (A) Flow cytometric analysis of live CD45 + cells from B16F10 melanoma tumors isolated from tamoxifen-treated Ptpn6 fl/fl and Ptpn6 fl/fl ERT2-cre mice at day 14 post tumor implantation. (B) B16F10 tumor volume measurements in tamoxifen-treated Ptpn6 fl/fl ERT2-cre and Ptpn6 fl/fl mice. Each data point represents the average tumor volume of all mice in a given group. Data is representative of three independent experiments with 5-7 mice/group. (C) Shp1 protein relative to total Erk2 protein in peripheral blood cells from indicated mice 14 days after initial tamoxifen dose (200 mg/kg bid for 4 days) and 7 days after B16F10 tumor cells were implanted. Data is representative of at least three independent experiments with 5-7 mice per group. (D) Flow cytometric analysis of live CD45 + cells from E0771 tumors isolated from tamoxifen-treated Ptpn6 fl/fl and Ptpn6 fl/fl ERT2-cre mice at day 19 post tumor implantation. (E) E0771 tumor volume measurements in tamoxifen-treated Ptpn6 fl/fl ERT2-cre and Ptpn6 fl/fl mice. Each data point represents the average tumor volume of all mice in a given group. Data is representative of three independent experiments with 4-5 mice per group. Statistical significance was calculated at each time point using an unpaired t -test. (F) Shp1 protein relative to total Erk2 protein in peripheral blood cells from indicated mice 14 days after initial tamoxifen d','shortDescription':'Figure 4 Ptpn6 deletion drives robust anti-tumor immunity in two immune-rich syngeneic tumor lines. (A) Flow cytometric analysis of live CD45 + cells from B16F10 melanoma tumors isolated from tamoxifen-treated Ptpn6 fl/fl and Ptpn6 fl/fl ERT2-cre mice at day 14 post tumor implantation. (B) B16F10 tumor volume measurements in tamoxifen-treated Ptpn6 fl/fl ERT2-cre and Ptpn6 fl/fl mice. Each data point repres... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Jun 14, 2021, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in immunology','journalText':'Frontiers in immunology 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_8372_fimmu-11-576310-g0004.jpg','benchSciPubmedId':'33133093'},{'sku':'17-0452-82','imageId':'840008','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12509_41467_2020_18491_Fig7_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12509_41467_2020_18491_Fig7_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12509_41467_2020_18491_Fig7_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12509_41467_2020_18491_Fig7_HTML.jpg?time\u003d20240507','sortOrder':'15','description':'Fig. 7 Lgr4/Gpr48 is involved in CML stem cell self-renewal in vivo. a RNA-Seq determinations of mRNA levels of the indicated GPCR family genes in LT-CML stem cells isolated from Gdpd3 +/+ tet-CML-affected mice (22 males, 12 females) and Gdpd3 -/- tet-CML-affected mice (five males, five females). Results are expressed as FPKM (see Methods). Data are the mean FPKM +- s.d. ( n \u003d 3 biologically independent samples) ( P -value, unpaired two-sided Student\u0027\u0027s t -test). Results of the MA-plot and GO term enrichment analyses for these RNA-Seq data are shown in Supplementary Fig. 11a, b . b Quantitation of the colony-forming capacity of Gdpd3 +/+ CML-LSK cells that were transduced with/without Cy3-labelled siRNA targetting mouse Lgr4/Gpr48 mRNA (mLgr4 #3 or Lgr4 #4). Cy3 + and Cy3 - CML-LSK cells were purified at 3 days post-transduction and plated in a semi-solid methylcellulose medium. Data are the mean colony number +- s.d. ( n \u003d 3) and are representative of three biologically independent experiments. ( P -value compared with control, unpaired two-sided Student\u0027\u0027s t -test). The relevant FACS data are shown in Supplementary Fig. 12 . c Absolute numbers of LT-CML stem cells isolated from BM of the two hind limbs of Lgr4 +/+ tet-CML-affected mice (four males, one female) and Lgr4 Gt/Gt tet-CML-affected mice (five females) ( n \u003d 5 biologically independent samples). Data are the mean absolute numbers +- s.d. of LT-CML stem cells ( P -value, unpaired two-sided Student\u0027\u0027s t -test). (See S','shortDescription':'Fig. 7 Lgr4/Gpr48 is involved in CML stem cell self-renewal in vivo. a RNA-Seq determinations of mRNA levels of the indicated GPCR family genes in LT-CML stem cells isolated from Gdpd3 +/+ tet-CML-affected mice (22 males, 12 females) and Gdpd3 -/- tet-CML-affected mice (five males, five females). Results are expressed as FPKM (see Methods). Data are the mean FPKM +- s.d. ( n \u003d 3 biologically independent sam... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Sep 17, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12509_41467_2020_18491_Fig7_HTML.jpg','benchSciPubmedId':'32943626'},{'sku':'17-0452-82','imageId':'839793','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12509_41467_2020_18491_Fig1_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12509_41467_2020_18491_Fig1_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12509_41467_2020_18491_Fig1_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12509_41467_2020_18491_Fig1_HTML.jpg?time\u003d20240507','sortOrder':'16','description':'Fig. 1 Gdpd3 is implicated in CML disease initiation in vivo. a Diagram of pathways of lysophospholipid biosynthesis. G3P is converted into LPAs, and LPAs are then converted into phospholipids by the addition of polar bases via the Kennedy (de novo) pathway. The Lands\u0027\u0027 cycle (remodelling pathway) generates lysophospholipids of distinct composition by substituting fatty acid ester and polar base groups of phospholipids. Lysophospholipase D Gdpd3 converts lysophospholipids back into LPAs by catalysing hydrolysis (magenta dotted line). (PC Phosphatidylcholine, PS Phosphatidylserine, PE Phosphatidylethanolamine, PI Phosphatidylinositol, LPC Lysophosphatidylcholine, LPS Lysophosphatidylserine, LPE Lysophosphatidylethanolamine, LPI Lysophosphatidylinositol). b qRT-PCR determination of Gdpd3 mRNA expression in LT-stem (LT), CD48, MPP, and LK cells (see Supplementary Fig.2) isolated from Gdpd3 +/+ tet-CML-affected (SCL-tTA + TRE-BCR-ABL1 + ) mice (one male, six females) or normal littermate (SCL-tTA + ) mice (four males, four females). Data are the mean ratio +- s.d. of transcript levels normalised to Actb ( n \u003d 3 biologically independent samples) ( P -value, unpaired two-sided Student\u0027\u0027s t -test). c Quantitation of the colony-forming capacity of Gdpd3 +/+ CML-LSK cells that were transduced with/without Cy3-labelled siRNA targetting mouse Gdpd3 mRNA (mGdpd3 siRNA #1 or #3). Cy3 + and Cy3 - CML-LSK cells were purified at 3 days post-transduction and plated in semi-solid methylcellulo','shortDescription':'Fig. 1 Gdpd3 is implicated in CML disease initiation in vivo. a Diagram of pathways of lysophospholipid biosynthesis. G3P is converted into LPAs, and LPAs are then converted into phospholipids by the addition of polar bases via the Kennedy (de novo) pathway. The Lands\u0027\u0027 cycle (remodelling pathway) generates lysophospholipids of distinct composition by substituting fatty acid ester and polar base groups of p... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Sep 17, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12509_41467_2020_18491_Fig1_HTML.jpg','benchSciPubmedId':'32943626'},{'sku':'17-0452-82','imageId':'727055','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_5903_fimmu-10-01980-g0002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_5903_fimmu-10-01980-g0002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_5903_fimmu-10-01980-g0002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_5903_fimmu-10-01980-g0002.jpg?time\u003d20240507','sortOrder':'17','description':'Figure 2 Tpl2 didn\u0027t affect peripheral immune activation during FH pathogenesis. The splenic cells or peripheral blood immune cells were isolated from P. acnes -primed WT and Tpl2 -KO mice at day 3, 5, and 7 as described in Materials and methods ( n \u003d 4 mice/group), and subjected for flow cytometry analysis. (A-F) Flow cytometry analysis of the frequencies and absolute numbers of CD4 + T cells, CD8 + T cells, B220 + B cells, CD11c + dendritic cells (A,B) , CD4 + Foxp3 + Treg cells (C,D) , and IFN-gamma- and TNF-alpha-producing pathogenic Th1 cells (E,F) in the spleens of WT and Tpl2 -KO mice at day 7 after P. acnes priming. Data are presented as representative plots of the frequencies of immune cell subpopulations (A,C,E) and a summary graph of the cell frequencies or absolute cell numbers (B,D,F) . (G-J) Flow cytometry analysis of the frequencies and absolute numbers of CD4 + T cells in the spleens (G,H) or peripheral blood (I,J) of WT and Tpl2 -KO mice at day 3, 5, and 7 after P. acnes priming. Data are presented as representative plots of the frequencies of immune cell subpopulations (G,I) and a summary graph of the cell frequencies or absolute cell numbers (H,J) . Results are mean +- SD from three independent experiments.','shortDescription':'Figure 2 Tpl2 didn\u0027t affect peripheral immune activation during FH pathogenesis. The splenic cells or peripheral blood immune cells were isolated from P. acnes -primed WT and Tpl2 -KO mice at day 3, 5, and 7 as described in Materials and methods ( n \u003d 4 mice/group), and subjected for flow cytometry analysis. (A-F) Flow cytometry analysis of the frequencies and absolute numbers of CD4 + T cells, CD8 + T cell... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Oct 14, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in immunology','journalText':'Frontiers in immunology 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_5903_fimmu-10-01980-g0002.jpg','benchSciPubmedId':'31481966'},{'sku':'17-0452-82','imageId':'727096','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_5903_fimmu-10-01980-g0003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_5903_fimmu-10-01980-g0003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_5903_fimmu-10-01980-g0003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_5903_fimmu-10-01980-g0003.jpg?time\u003d20240507','sortOrder':'18','description':'Figure 3 Tpl2 reduced liver infiltration of pathogenic CD4 + T cells. Liver-infiltrating immune cells were isolated from P. acnes -primed WT and Tpl2 -KO mice at day 3, 5, and 7 as described in Materials and methods ( n \u003d 4 mice/group). (A-G) Flow cytometry analysis of the frequencies and absolute numbers of CD4 + and CD8 + T cells, B220 + B cell, CD11c + dendritic cells (A-C) , CD4 + Foxp3 + Treg cells (D,E) , and IFN-gamma- and TNF-alpha-producing pathogenic Th1 cells (F,G) in the livers of WT and Tpl2 -KO mice at day 7 after P. acnes priming. Data are presented as representative plots of the frequencies of immune cell subpopulations (A,D,F) and a summary graph of the frequencies and absolute cell numbers (B,C,E,G) . (H,I) Flow cytometry analysis of the frequencies and absolute numbers of CD4 + T cells in the livers of WT and Tpl2 -KO mice at day 3, 5, and 7 after P. acnes priming. Data are presented as representative plots of the frequencies of immune cell subpopulations (H) and a summary graph of the absolute cell numbers (I) . Results are mean +- SD from three independent experiments. Two-tailed Student\u0027s t -tests were performed. * P \u003c 0.05; ** P \u003c 0.01.','shortDescription':'Figure 3 Tpl2 reduced liver infiltration of pathogenic CD4 + T cells. Liver-infiltrating immune cells were isolated from P. acnes -primed WT and Tpl2 -KO mice at day 3, 5, and 7 as described in Materials and methods ( n \u003d 4 mice/group). (A-G) Flow cytometry analysis of the frequencies and absolute numbers of CD4 + and CD8 + T cells, B220 + B cell, CD11c + dendritic cells (A-C) , CD4 + Foxp3 + Treg cells (D,... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Oct 14, 2020, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in immunology','journalText':'Frontiers in immunology 2020 - ','sourceType':'3','benchsci':true,'imageName':'tfs_5903_fimmu-10-01980-g0003.jpg','benchSciPubmedId':'31481966'},{'sku':'17-0452-82','imageId':'849950','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_7721_41467_2019_9884_Fig6_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_7721_41467_2019_9884_Fig6_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_7721_41467_2019_9884_Fig6_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_7721_41467_2019_9884_Fig6_HTML.jpg?time\u003d20240507','sortOrder':'19','description':'Fig. 6 TLR2 + macrophages, pDCs, and PB in the small intestine bind PSA and induce IL-10 secretion. Gating strategy for mononuclear cells isolated from a duodenum (Duod) and b ileum (Ile) of WT and Rag mice analyzed for binding of fluorescent A488-conjugated PSA (left two plots). CD45 - intra-epithelial cells (CD45 - IEC: middle histogram) and CD45 + gated intra-epithelial leukocytes (CD45 + IEL: second right histogram) isolated from the a Duod and b Ile of WT (red) and Rag (blue) mice were analyzed for reactivity to PSA-A488. CD45 + CD11c - B220 + B cells, PDCA1 + B220 + CD11c + pDCs and CD138 + B220 + PB and B220 low PC isolated from a Duod and b Ile of WT mice were analyzed for PSA reactivity (right histogram). Flow cytometry plots show CD11c + PDCA1 - cDC, PDCA1 + B220 + pDC, and B220 + CD19 + B cells isolated from spleen, MLN, PP, IEL, or LP of WT mice were stimulated with c PSA or d LTA-SA (TLR2 agonist) and analyzed for IL-10 expression. e Plots summarize data from c and d and show % IL-10 + B cells (left), cDCs (middle), and pDCs (right) from spleen, MLN, PP, IEL, and LP stimulated with PSA or TLR2 (LTA-SA) ( n \u003d 3 mice). All data show mean +- SEM','shortDescription':'Fig. 6 TLR2 + macrophages, pDCs, and PB in the small intestine bind PSA and induce IL-10 secretion. Gating strategy for mononuclear cells isolated from a duodenum (Duod) and b ileum (Ile) of WT and Rag mice analyzed for binding of fluorescent A488-conjugated PSA (left two plots). CD45 - intra-epithelial cells (CD45 - IEC: middle histogram) and CD45 + gated intra-epithelial leukocytes (CD45 + IEL: second rig... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'May 14, 2019, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_7721_41467_2019_9884_Fig6_HTML.jpg','benchSciPubmedId':'31089128'},{'sku':'17-0452-82','imageId':'843512','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12887_nihms-1545821-f0008.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12887_nihms-1545821-f0008.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12887_nihms-1545821-f0008.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12887_nihms-1545821-f0008.jpg?time\u003d20240507','sortOrder':'20','description':'Figure 7. NOX2 and FOXC1 Are Important for the Growth of Primary Human Myeloid Leukemia Cells (A) The Cancer Genome Atlas (TCGA) database for AML was used to analyze the expression levels of several NADPH-dependent oxidases (NOX1-NOX5), accessory subunits (NCF1, NCF2, NCF4, NOXA1, NOXO1, p22Phox, RAC1, and RAC2) as well as related oxido-reductase enzymes (dual-oxidases 1,2, A2). The reads per kilobase of transcript per million mapped reads (RPKM) values for each gene in a total of 188 AMLs are shown. (B) RNA-seq analysis was performed on functionally validated leukemic stem cells isolated from human primary AMLs. The RPKM value for each gene is shown. Unpublished data are used with permission. Additional supporting data are shown in Figure S7A . (C) Equal numbers of control or shNOX2-transduced primary AML cells were cultured in vitro in the presence of 10 ng/mL of IL-3, SCF, and FL3, and the relative percent expansion is reported for each specimen. n \u003d 3, mean +- SD. *p \u003c 0.05; **p \u003c 0.01. (D) Control and shNOX2 primary AML cells were purified and cultured in vitro for 12 days. Annexin V, DAPI staining was performed to evaluate the degree of apoptotic cell death. A representative flow plot (left) and quantitation of 3 technical triplicates (right) are shown. Additional data are shown in Figure S7B . (E) The relative expression level of NOX2 , CEBP epsilon, Elane , and CTSG is shown in AML specimens in which NOX2 was knocked down using shRNAs. Additional supporting data are p','shortDescription':'Figure 7. NOX2 and FOXC1 Are Important for the Growth of Primary Human Myeloid Leukemia Cells (A) The Cancer Genome Atlas (TCGA) database for AML was used to analyze the expression levels of several NADPH-dependent oxidases (NOX1-NOX5), accessory subunits (NCF1, NCF2, NCF4, NOXA1, NOXO1, p22Phox, RAC1, and RAC2) as well as related oxido-reductase enzymes (dual-oxidases 1,2, A2). The reads per kilobase of tr... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Apr 2, 2019, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell reports','journalText':'Cell reports 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12887_nihms-1545821-f0008.jpg','benchSciPubmedId':'30943405'},{'sku':'17-0452-82','imageId':'736879','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_7916_fimmu-09-03114-g0002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_7916_fimmu-09-03114-g0002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_7916_fimmu-09-03114-g0002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_7916_fimmu-09-03114-g0002.jpg?time\u003d20240507','sortOrder':'21','description':'Figure 2 Analysis of the B lymphocyte populations expanded in TRAF3/BCL2 double-tg mice with lymphoid dyscrasias. Three-color flow-cytometry analysis was performed to determine the phenotype of expanded B lymphocyte populations. Gating of the expanded population was based on the CD45R/B220 and FSC plot of each sample analyzed and is indicated in the figure. The surface molecules analyzed are indicated in the plots, as well as the percentage of cells found in each quadrant. The quadrants settings were selected based on the staining of isotype-controls (not shown). The tissue source where the analyzed lymphocytes were extracted from and the type of B cell malignancy developed by the TRAF3/BCL2 double-tg mice, according to the flow-cytometry and immunohistochemical analysis, is indicated in the figure.','shortDescription':'Figure 2 Analysis of the B lymphocyte populations expanded in TRAF3/BCL2 double-tg mice with lymphoid dyscrasias. Three-color flow-cytometry analysis was performed to determine the phenotype of expanded B lymphocyte populations. Gating of the expanded population was based on the CD45R/B220 and FSC plot of each sample analyzed and is indicated in the figure. The surface molecules analyzed are indicated in ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Oct 25, 2019, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in immunology','journalText':'Frontiers in immunology 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_7916_fimmu-09-03114-g0002.jpg','benchSciPubmedId':'30687320'},{'sku':'17-0452-82','imageId':'521453','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_4977_fimmu-09-02522-g0007.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_4977_fimmu-09-02522-g0007.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_4977_fimmu-09-02522-g0007.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_4977_fimmu-09-02522-g0007.jpg?time\u003d20240507','sortOrder':'22','description':'Figure 7 ATF3 promotes IL-22-induced STAT3 phosphorylation by suppressing phosphatases. (A) Freshly isolated ileum crypts, or (B) ileum organoids at day 6 of culture, were stimulated with IL-22, followed by fixation and intracellular staining of phospho-STAT3, and analyzed by flow cytometry. Western blot analysis of (C) IL-22-stimulated CMT93 cells, or (D) IL-22-stimuated colon fragments isolated from the indicated mice, for the expression of the indicated proteins. (E) Quantitative real-time PCR analysis of IL-22R1 and IL-10R2 mRNA levels in freshly isolated ileum crypts from mice. (F) Flow cytometry analysis of IL-22R1 in freshly isolated ileum crypt cells gated on the CD45 - EpCAM + population. (G,H) Western blot analysis of unstimulated or IL-22-stimulated CMT93 cells for the indicated proteins. ATF3 -/- CMT93 cells with SHP2 knockdown (ATF3 -/- SHP2 KD ) were indicated. Images were representative of four independent experiments (G-H) . Results were from two independent experiments (A-F) . \'\'n\'\' refers to the number of mice analyzed (A,B,E,F) . Statistical analysis was done by multiple comparison in Two-way ANOVA test using Prism software. * P \u003c 0.05, ** P \u003c 0.005, *** P \u003c 0.0005.','shortDescription':'Figure 7 ATF3 promotes IL-22-induced STAT3 phosphorylation by suppressing phosphatases. (A) Freshly isolated ileum crypts, or (B) ileum organoids at day 6 of culture, were stimulated with IL-22, followed by fixation and intracellular staining of phospho-STAT3, and analyzed by flow cytometry. Western blot analysis of (C) IL-22-stimulated CMT93 cells, or (D) IL-22-stimuated colon fragments isolated ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Sep 26, 2019, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in immunology','journalText':'Frontiers in immunology 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_4977_fimmu-09-02522-g0007.jpg','benchSciPubmedId':'30455690'},{'sku':'17-0452-82','imageId':'521452','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_4977_fimmu-09-02522-g0001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_4977_fimmu-09-02522-g0001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_4977_fimmu-09-02522-g0001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_4977_fimmu-09-02522-g0001.jpg?time\u003d20240507','sortOrder':'23','description':'Figure 1 ATF3 maintains intestinal homeostasis. (A) Comparison of colon length between naive mice as indicated. (B) Colon crypts from mice were isolated by shaking colon fragments in EDTA and counted under light microscopy. (C) Flow cytometry analysis of Ki67 and CD24 expression in ileum crypts, gated on the CD45 - EpCAM + populations, from the indicated naive mice. (D) Representative micrographs showing intestinal organoids derived from naive mice. (E) Quantitative real-time PCR analysis of cell cycle genes in naive ileum organoids at day 6 of culture (\'\'n\'\' indicates organoids derived from 4 mice each group). (F) Representative confocal images of whole mount tissues with co-immunofluorescence staining of UEA-1 and WGA in naive ileum villi. Results were from at least two independent experiments and \'\'n\'\' refers to the number of mice unless indicated otherwise. All mice were at the age of 2~3 months old when analyzed. Statistical analysis was done using Multiple T -test on Prism software. * P \u003c 0.05, ** P \u003c 0.005, *** P \u003c 0.0005.','shortDescription':'Figure 1 ATF3 maintains intestinal homeostasis. (A) Comparison of colon length between naive mice as indicated. (B) Colon crypts from mice were isolated by shaking colon fragments in EDTA and counted under light microscopy. (C) Flow cytometry analysis of Ki67 and CD24 expression in ileum crypts, gated on the CD45 - EpCAM + populations, from the indicated naive mice. (D) Representative micrographs... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Sep 26, 2019, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in immunology','journalText':'Frontiers in immunology 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_4977_fimmu-09-02522-g0001.jpg','benchSciPubmedId':'30455690'},{'sku':'17-0452-82','imageId':'485901','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_4528_41467_2018_4831_Fig1_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_4528_41467_2018_4831_Fig1_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_4528_41467_2018_4831_Fig1_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_4528_41467_2018_4831_Fig1_HTML.jpg?time\u003d20240507','sortOrder':'24','description':'Fig. 1 Loss of miR-143/145 results in reduced LT-HSC frequency. a Frequency of long-term-HSC (LT-HSC, CD45 + EPCR + CD48 - CD150 + ), LSK/short-term HSC (Lin - Sca1 + c-Kit + ), common myeloid progenitors (CMP, Lin - Sca1 - c-Kit + CD34 + CD16/32 lo ), granulocyte-macrophage progenitors (GMP, Lin - Sca1 - c-Kit + CD34 + CD16/32 hi ), and megakaryocyte-erythrocyte progenitors (MEPs, Lin - Sca1 - c-Kit + CD34 - CD16/32 lo ) in the marrow of 8-12-week- old wild-type (WT), miR-143/145 +/- , and miR-143/145 -/- mice, as analyzed by flow cytometry (median +- 1.5 IQR, WT n \u003d 11, 143/145 +/- n \u003d 9, 143/145 -/- n \u003d 8). b Marrow cellularity (2 femurs and 2 tibias) (WT n \u003d 3, 143/145 +/- n \u003d 4, 143/145 -/- n \u003d 8). c Colony-forming unit (CFU) assay of marrow cells from WT and miR-143/145 -/- mice (mean +- SEM, WT n \u003d 11, 143/145 -/- n \u003d 10). d Primary CFU cells were replated in equal proportions per condition, normalized to the number of input cells, to generate secondary CFUs (mean +- SEM, WT n \u003d 9, 143/145 -/- n \u003d 7). e Estimate of HSC frequency in WT and miR-143/145 -/- mice by limiting dilution assay. Shown is a log-fraction plot of the limiting dilution model. The slope of the line is the log-active cell fraction. The dotted lines give the 95% CI','shortDescription':'Fig. 1 Loss of miR-143/145 results in reduced LT-HSC frequency. a Frequency of long-term-HSC (LT-HSC, CD45 + EPCR + CD48 - CD150 + ), LSK/short-term HSC (Lin - Sca1 + c-Kit + ), common myeloid progenitors (CMP, Lin - Sca1 - c-Kit + CD34 + CD16/32 lo ), granulocyte-macrophage progenitors (GMP, Lin - Sca1 - c-Kit + CD34 + CD16/32 hi ), and megakaryocyte-erythrocyte progenitors (MEPs, Lin - Sca1 - c-Kit + CD34... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Jun 20, 2018, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2018 - ','sourceType':'3','benchsci':true,'imageName':'tfs_4528_41467_2018_4831_Fig1_HTML.jpg','benchSciPubmedId':'29925839'},{'sku':'17-0452-82','imageId':'933519','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14845_nihms-1001095-f0003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14845_nihms-1001095-f0003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14845_nihms-1001095-f0003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14845_nihms-1001095-f0003.jpg?time\u003d20240507','sortOrder':'25','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Jun 28, 2018, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell','journalText':'Cell 2018 - ','sourceType':'3','benchsci':true,'imageName':'tfs_14845_nihms-1001095-f0003.jpg','benchSciPubmedId':'29909986'},{'sku':'17-0452-82','imageId':'521451','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_4672_nihms950683f4.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_4672_nihms950683f4.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_4672_nihms950683f4.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_4672_nihms950683f4.jpg?time\u003d20240507','sortOrder':'26','description':'Figure 4 Surgical denervation of young bone marrow induces premature HSC and niche aging (a) Schematic illustration of surgical denervation experiment. The sciatic and femoral nerves were transected in young (2 months old) C57BL/6 mice and the mice were analyzed 4 months post surgery, at 6 months of age. (b) Absolute numbers of HSCs (lineage - Sca-1 + c-Kit + CD48 - CD150 + ) isolated from Sham and Denervated (Den) femurs (n\u003d7 mice). (c, d) Total peripheral blood (CD45.2 + ), blood myeloid (Mac-1 + CD45.2 + ) and blood B cell (B220 + CD45.2 + ) donor chimerism at the indicated time points post transplantation (c) and bone marrow donor chimerism (Total CD45.2 + (BM); Myeloid (My), Mac-1 + CD45.2 + ; B cell (B), B220 + CD45.2 +; and T cell (T), CD4 + /CD8 + CD45.2 + ) 5 months after primary transplantation of 200 HSCs derived from either sham or denervated (Den) femurs and transplanted in competition with young BM competitor cells (n\u003d4 sham, 6 denervated mice) (left) and 5 months after secondary transplantation of 3 x 10 6 bone marrow from primary recipients (right) (d). (e) Left, representative confocal z -stack projections of HSCs sorted from sham or denervated femurs and stained with Cdc42, Tubulin and DAPI. Scale bar, 10 mum. Right, quantification of the percentage of Cdc42 and Tubulin polarized HSCs out of total HSCs scored (total of 356 sham and 353 denervated HSCs isolated from 4 mice per group). (f) Left, representative confocal z -stack pro','shortDescription':'Figure 4 Surgical denervation of young bone marrow induces premature HSC and niche aging (a) Schematic illustration of surgical denervation experiment. The sciatic and femoral nerves were transected in young (2 months old) C57BL/6 mice and the mice were analyzed 4 months post surgery, at 6 months of age. (b) Absolute numbers of HSCs (lineage - Sca-1 + c-Kit + CD48 - CD150 + ) isolated from Sham an... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Jun 1, 2018, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature medicine','journalText':'Nature medicine 2018 - ','sourceType':'3','benchsci':true,'imageName':'tfs_4672_nihms950683f4.jpg','benchSciPubmedId':'29736022'},{'sku':'17-0452-82','imageId':'341735','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_4316_fimmu-09-00592-g002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_4316_fimmu-09-00592-g002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_4316_fimmu-09-00592-g002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_4316_fimmu-09-00592-g002.jpg?time\u003d20240507','sortOrder':'27','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'May 1, 2019, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Frontiers in immunology','journalText':'Frontiers in immunology 2019 - ','sourceType':'3','benchsci':true,'imageName':'tfs_4316_fimmu-09-00592-g002.jpg','benchSciPubmedId':'29623080'},{'sku':'17-0452-82','imageId':'625022','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_4095_etm-15-02-1847-g00.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_4095_etm-15-02-1847-g00.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_4095_etm-15-02-1847-g00.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_4095_etm-15-02-1847-g00.jpg?time\u003d20240507','sortOrder':'28','description':'Figure 1. VEGF and bFGF promote the differentiation of MSCs into EC-like cells. (A) Expression of MSC surface markers was confirmed using flow cytometry. (B) Morphological features of isolated MSCs and MSC-derived EC-like cells following induction as observed under an inverted microscope. The red and white arrows indicate spindle-shaped and polygon-shaped cells, respectively. Magnification, x20. (C) Factor VIII expression was detected in MSC-derived EC-like cells via immunohistochemistry and light microscopy with brown staining indicating the positive signal. VEGF, vascular endothelial growth factor; bFGF, basic fibroblast growth factor; MSCs, mesenchymal stem cells; EC, endothelial cell; Ctrl, control; CD, cluster of differentiation.','shortDescription':'Figure 1. VEGF and bFGF promote the differentiation of MSCs into EC-like cells. (A) Expression of MSC surface markers was confirmed using flow cytometry. (B) Morphological features of isolated MSCs and MSC-derived EC-like cells following induction as observed under an inverted microscope. The red and white arrows indicate spindle-shaped and polygon-shaped cells, respectively. Magnification, x20. (C) Facto... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Feb 1, 2018, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Experimental and therapeutic medicine','journalText':'Experimental and therapeutic medicine 2018 - ','sourceType':'3','benchsci':true,'imageName':'tfs_4095_etm-15-02-1847-g00.jpg','benchSciPubmedId':'29434774'},{'sku':'17-0452-82','imageId':'726989','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_6017_zjv0061833750003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_6017_zjv0061833750003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_6017_zjv0061833750003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_6017_zjv0061833750003.jpg?time\u003d20240507','sortOrder':'29','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Mar 15, 2018, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of virology','journalText':'Journal of virology 2018 - ','sourceType':'3','benchsci':true,'imageName':'tfs_6017_zjv0061833750003.jpg','benchSciPubmedId':'29298882'},{'sku':'17-0452-82','imageId':'489862','imageUrl':'https://www.thermofisher.com/antibody/images/650/jbmr3352-fig-0005-1-20190103084817.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/jbmr3352-fig-0005-1-20190103084817.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/jbmr3352-fig-0005-1-20190103084817.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/jbmr3352-fig-0005-1-20190103084817.jpg?time\u003d20240507','sortOrder':'30','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Apr 1, 2018, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research','journalText':'Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2018 - ','sourceType':'3','benchsci':true,'imageName':'jbmr3352-fig-0005-1-20190103084817.jpg','benchSciPubmedId':'29206332'},{'sku':'17-0452-82','imageId':'489843','imageUrl':'https://www.thermofisher.com/antibody/images/650/jbmr3352-fig-0002-1-20190103084817.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/jbmr3352-fig-0002-1-20190103084817.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/jbmr3352-fig-0002-1-20190103084817.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/jbmr3352-fig-0002-1-20190103084817.jpg?time\u003d20240507','sortOrder':'31','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Apr 1, 2018, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research','journalText':'Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2018 - ','sourceType':'3','benchsci':true,'imageName':'jbmr3352-fig-0002-1-20190103084817.jpg','benchSciPubmedId':'29206332'},{'sku':'17-0452-82','imageId':'663041','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_5557_41467_2017_1022_Fig7_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_5557_41467_2017_1022_Fig7_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_5557_41467_2017_1022_Fig7_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_5557_41467_2017_1022_Fig7_HTML.jpg?time\u003d20240507','sortOrder':'32','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Oct 18, 2017, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2017 - ','sourceType':'3','benchsci':true,'imageName':'tfs_5557_41467_2017_1022_Fig7_HTML.jpg','benchSciPubmedId':'29044097'},{'sku':'17-0452-82','imageId':'663019','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_5557_41467_2017_1022_Fig5_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_5557_41467_2017_1022_Fig5_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_5557_41467_2017_1022_Fig5_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_5557_41467_2017_1022_Fig5_HTML.jpg?time\u003d20240507','sortOrder':'33','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Oct 18, 2017, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2017 - ','sourceType':'3','benchsci':true,'imageName':'tfs_5557_41467_2017_1022_Fig5_HTML.jpg','benchSciPubmedId':'29044097'},{'sku':'17-0452-82','imageId':'662997','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_5557_41467_2017_1022_Fig2_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_5557_41467_2017_1022_Fig2_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_5557_41467_2017_1022_Fig2_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_5557_41467_2017_1022_Fig2_HTML.jpg?time\u003d20240507','sortOrder':'34','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Oct 18, 2017, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2017 - ','sourceType':'3','benchsci':true,'imageName':'tfs_5557_41467_2017_1022_Fig2_HTML.jpg','benchSciPubmedId':'29044097'},{'sku':'17-0452-82','imageId':'662975','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_5557_41467_2017_1022_Fig1_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_5557_41467_2017_1022_Fig1_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_5557_41467_2017_1022_Fig1_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_5557_41467_2017_1022_Fig1_HTML.jpg?time\u003d20240507','sortOrder':'35','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Oct 18, 2017, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2017 - ','sourceType':'3','benchsci':true,'imageName':'tfs_5557_41467_2017_1022_Fig1_HTML.jpg','benchSciPubmedId':'29044097'},{'sku':'17-0452-82','imageId':'333988','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_3817_41467_2017_1029_Fig1_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_3817_41467_2017_1029_Fig1_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_3817_41467_2017_1029_Fig1_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_3817_41467_2017_1029_Fig1_HTML.jpg?time\u003d20240507','sortOrder':'36','description':'Fig. 1 In vivo depletion of Cdkn1a rescues GC formation in Ezh2 -/- mice. Ezh2 fl/fl , Cdkn1a -/- , Ezh2 fl/fl ;Cgamma1-cre and Ezh2 fl/fl ;Cgamma1-cre; Cdkn1a -/- littermate mice were immunized with SRBC to induce germinal center (GC) formation and were killed 10 days later. a Flow cytometry plot of one representative mouse spleen per group. The gated area shows the percentage of GC B cells (GL7 + FAS + ) within live B cells (B220 + DAPI-, see Supplementary Fig. 2A for gating strategy). b Average of GC B populations of each group of mice quantified by flow cytometry as in a ( n \u003d 7 mice per group). c Formalin fixed paraffin embedded splenic tissue was stained for PNA, Ki67, EZH2, and B220. One representative picture of three spleens analyzed per group is shown. d - f Quantification of PNA staining from c ( n \u003d 3 spleens per group). d \'\'#GC/spleen section\'\' is the count of all GC per spleen section. e \'\'GC area/total spleen area\'\' is the quantified area of each individual GC divided by the total area of the spleen section. f \'\'Total GC area/total spleen area\'\' is the sum of all GC quantified areas in a certain section divided by the total area of that spleen section. g Splenocytes were permeabilized and stained for GC B and EZH2 using a fluorochrome-conjugated anti EZH2 antibody. The gated area shows the percentage of GC B cells (GL7 + FAS + ) within live B cells (B220 + DAPI-, see Supplementary Fig. 2A for gating strategy) that are EZH2 positive. The flow plot shown is repre','shortDescription':'Fig. 1 In vivo depletion of Cdkn1a rescues GC formation in Ezh2 -/- mice. Ezh2 fl/fl , Cdkn1a -/- , Ezh2 fl/fl ;Cgamma1-cre and Ezh2 fl/fl ;Cgamma1-cre; Cdkn1a -/- littermate mice were immunized with SRBC to induce germinal center (GC) formation and were killed 10 days later. a Flow cytometry plot of one representative mouse spleen per group. The gated area shows the percentage of GC B cells (GL7 + FAS + ) ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Oct 12, 2017, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2017 - ','sourceType':'3','benchsci':true,'imageName':'tfs_3817_41467_2017_1029_Fig1_HTML.jpg','benchSciPubmedId':'29026085'},{'sku':'17-0452-82','imageId':'333287','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_3817_41467_2017_1029_Fig3_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_3817_41467_2017_1029_Fig3_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_3817_41467_2017_1029_Fig3_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_3817_41467_2017_1029_Fig3_HTML.jpg?time\u003d20240507','sortOrder':'37','description':'Fig. 3 Characterization of a 3D B cell follicular organoid to model the GC reaction. a Scheme of 3D B cell follicular organoid fabrication. Splenic B cells are co-encapsulated with 40LB stromal cells and IL4 into an RGD-presenting nanocomposite hydrogel that contain gelatin ionically cross-linked with synthetic silicate nanoparticles. b Representative fluorescence pictures of splenic GFP B cells in 3D organoid culture. c Flow cytometry plot of a 3D B cell follicular organoid. The gated area on the top shows the live B cells (B220 + DAPI-) and on the bottom plot, the organoid GC B cells (GL7 + FAS + ) within live B cells. d Average of GC B populations of organoids quantified as in c . e Average of percentage of proliferating organoid GC B populations, quantified as indicated in Supplementary Fig. 4B . f MFI of proliferation dye from e . g Flow cytometry plot of GC B cells stained with annexinV. h Average of percentage of apoptotic GC B cells quantified as in g . i RNA-seq profiles of organoid GC B cells after 4 and 6 days in culture (organoid GCB d4, n \u003d 4 spleens, and d6, n \u003d 3 spleens) were projected into the principal component space defined by GC B cells sorted from immunized mice (in vivo GCB, n \u003d 6 mice), CD138 + plasma cells (in vivo PC, n \u003d 6 mice) and FAS-GL7-IgD + B220 + naive B cells (NB, n \u003d 3 mice). j , k Heat maps of gene expression level of GC B cells showed in i , represented as log2 ratio relative to mean naive B cells j and to mean plasma cells k . PC1/2 \u003d pr','shortDescription':'Fig. 3 Characterization of a 3D B cell follicular organoid to model the GC reaction. a Scheme of 3D B cell follicular organoid fabrication. Splenic B cells are co-encapsulated with 40LB stromal cells and IL4 into an RGD-presenting nanocomposite hydrogel that contain gelatin ionically cross-linked with synthetic silicate nanoparticles. b Representative fluorescence pictures of splenic GFP B cells in 3D organ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Oct 12, 2017, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2017 - ','sourceType':'3','benchsci':true,'imageName':'tfs_3817_41467_2017_1029_Fig3_HTML.jpg','benchSciPubmedId':'29026085'},{'sku':'17-0452-82','imageId':'332858','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_3817_41467_2017_1029_Fig4_HTML.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_3817_41467_2017_1029_Fig4_HTML.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_3817_41467_2017_1029_Fig4_HTML.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_3817_41467_2017_1029_Fig4_HTML.jpg?time\u003d20240507','sortOrder':'38','description':'Fig. 4 CDKN1A repression by EZH2 is required for GC B cell cycle progression. a - f Organoids were generated using B cells isolated from Ezh2 fl/fl ;Cgamma1-cre, Cdkn1a -/- , Ezh2 fl/fl ;Cgamma1-cre; Cdkn1a -/- and Ezh2 fl/fl control mice ( n \u003d 3 mice per group) and were harvested for flow cytometry analysis after 4 days in culture. a Flow cytometry plots of representative organoids from each genotype. The gated area shows the percentage of organoid GC B cells (GL7 + FAS + ) within live B cells (B220 + DAPI-). b Average of percentage of organoid GC B populations quantified by flow cytometry as in a ( n \u003d 3 biological replicates per group). c Organoids received a BrdU pulse of 2 h before harvest. Cell cycle was analyzed by BrdU staining and 7AAD to measure DNA content. The representative gated area shows the percentage of organoid GC B cells (GL7 + FAS + B220 + DAPI-) that are in S phase (BrdU + ). d Average of percentage of organoid GC B populations in S phase of each group of genotype quantified by flow cytometry as in c ( n \u003d 3 biological replicates per group). e Organoid cells were permeabilized and stained for EZH2 and GC markers GL7, FAS, and B220 to identify organoid GC B cells. The flow cytometry plot shows one representative sample per genotype group. f MFI of EZH2 in organoid GC B cells ( n \u003d 3) quantified by flow cytometry as in e . g - m Organoids were generated using B cells isolated from 3 Cdkn1a +/+ and 3 Cdkn1a -/- mice. g Scheme of EZH2 inhibitor GSK343 and Br','shortDescription':'Fig. 4 CDKN1A repression by EZH2 is required for GC B cell cycle progression. a - f Organoids were generated using B cells isolated from Ezh2 fl/fl ;Cgamma1-cre, Cdkn1a -/- , Ezh2 fl/fl ;Cgamma1-cre; Cdkn1a -/- and Ezh2 fl/fl control mice ( n \u003d 3 mice per group) and were harvested for flow cytometry analysis after 4 days in culture. a Flow cytometry plots of representative organoids from each genotype. The ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Oct 12, 2017, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2017 - ','sourceType':'3','benchsci':true,'imageName':'tfs_3817_41467_2017_1029_Fig4_HTML.jpg','benchSciPubmedId':'29026085'},{'sku':'17-0452-82','imageId':'342982','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_3786_jciinsight-2-91914-g009.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_3786_jciinsight-2-91914-g009.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_3786_jciinsight-2-91914-g009.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_3786_jciinsight-2-91914-g009.jpg?time\u003d20240507','sortOrder':'39','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Aug 17, 2017, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'JCI insight','journalText':'JCI insight 2017 - ','sourceType':'3','benchsci':true,'imageName':'tfs_3786_jciinsight-2-91914-g009.jpg','benchSciPubmedId':'28814662'},{'sku':'17-0452-82','imageId':'726931','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_5933_koni-06-03-1287247-g004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_5933_koni-06-03-1287247-g004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_5933_koni-06-03-1287247-g004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_5933_koni-06-03-1287247-g004.jpg?time\u003d20240507','sortOrder':'40','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Jan 12, 2021, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Oncoimmunology','journalText':'Oncoimmunology 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_5933_koni-06-03-1287247-g004.jpg','benchSciPubmedId':'28405519'},{'sku':'17-0452-82','imageId':'334341','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_3431_pone0171796g006.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_3431_pone0171796g006.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_3431_pone0171796g006.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_3431_pone0171796g006.jpg?time\u003d20240507','sortOrder':'41','description':'Fig 6 Tn P acts systemically during the induction phase modulating DCs and induces regulatory cells. Splenocytes from EAE mice treated with vehicle or Tn P (n \u003d 5/group) were isolated at day 7, and analyzed. A ) The MFI of MHC class II, CD40, CD80, CD86 in cDC (CD11c+CD11b+) and B ) MFI of PDL-1 and PDL-2 in pDC (CD11c+B220 low ) were analyzed by flow cytometry (50,000 events). C ) The percentage of CD4+ cells, D ) and the MFI of CD18, CD40L, and CD69 in the CD4+ gate were analyzed by flow cytometry. E , F , G ) The percentages of FOXP3-positive CD4+CD25+ Treg, IL-4-positive CD4 Th2 cells and CD5-positive CD19+CD1d+ Breg cells were analyzed by flow cytometry. Values in the bar graphs are the mean +- SEM. * p \u003c 0.05 and ** p \u003c 0.01 compared with vehicle-treated EAE-mice.','shortDescription':'Fig 6 Tn P acts systemically during the induction phase modulating DCs and induces regulatory cells. Splenocytes from EAE mice treated with vehicle or Tn P (n \u003d 5/group) were isolated at day 7, and analyzed. A ) The MFI of MHC class II, CD40, CD80, CD86 in cDC (CD11c+CD11b+) and B ) MFI of PDL-1 and PDL-2 in pDC (CD11c+B220 low ) were analyzed by flow cytometry (50,000 events). C ) The percentage of CD4+ ce... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Aug 17, 2017, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'PloS one','journalText':'PloS one 2017 - ','sourceType':'3','benchsci':true,'imageName':'tfs_3431_pone0171796g006.jpg','benchSciPubmedId':'28235052'},{'sku':'17-0452-82','imageId':'319254','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_8502_JEM_20160247_Fig5.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_8502_JEM_20160247_Fig5.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_8502_JEM_20160247_Fig5.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_8502_JEM_20160247_Fig5.jpg?time\u003d20240507','sortOrder':'42','description':'Figure 5. K14Cre;fl/fl mice exhibit prominent autoimmunity with Th2/Th17 cell polarization and abnormal B cell activation leading to autoantibody production. (A) A representative image of the gross appearance of spleens and inguinal lymph nodes from 3-mo-old fl/fl and K14Cre;fl/fl mice. (B) The number of splenocytes in 3-mo-old fl/fl and K14Cre;fl/fl mice was counted. n \u003d 4 per each group. (C) Lymphocytes isolated from inguinal lymph nodes were stained for CD3 and CD4 and intracellularly stained for IL-4, IL-17A, and IFN-gamma. (Top) Representative two-dimensional plots for IL-4 and IL-17A in CD3 + CD4 + cells. (Bottom) The percentages of cells positive for IL-4, IL-17A, and IFN-gamma are summarized. n \u003d 7 mice per each group. (D) Splenocytes from 3-mo-old fl/fl and K14Cre;fl/fl mice were stained for B220 and CD19. B220 + CD19 + cells were analyzed for CD19 expression. A representative histogram of mean fluorescence intensity (MFI; top) and the comparison of mean fluorescence intensities (bottom) are shown. n \u003d 4 mice per genotype. (E) Sera from 3- and 8-mo-old mice were analyzed for the concentrations of total IgG, IgM, and IgA. n \u003d 5-7 mice per genotype. Note that the results are shown with log scale. (F) Sera from 1-, 2-, 3-, and 8-mo-old mice were analyzed for the concentration of IL-6. n \u003d 6-7 mice per genotype. (G) B cells were isolated from splenocytes of 3-mo-old mice and cultured for 48 h, either unstimulated or stimulated with anti-CD40 antibody (alphaCD40Ab). The c','shortDescription':'Figure 5. K14Cre;fl/fl mice exhibit prominent autoimmunity with Th2/Th17 cell polarization and abnormal B cell activation leading to autoantibody production. (A) A representative image of the gross appearance of spleens and inguinal lymph nodes from 3-mo-old fl/fl and K14Cre;fl/fl mice. (B) The number of splenocytes in 3-mo-old fl/fl and K14Cre;fl/fl mice was counted. n \u003d 4 per each group. (C) Lymphocytes i... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Apr 3, 2017, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'The Journal of experimental medicine','journalText':'The Journal of experimental medicine 2017 - ','sourceType':'3','benchsci':true,'imageName':'tfs_8502_JEM_20160247_Fig5.jpg','benchSciPubmedId':'28232470'},{'sku':'17-0452-82','imageId':'319835','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12866_nihms845084f5.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12866_nihms845084f5.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12866_nihms845084f5.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12866_nihms845084f5.jpg?time\u003d20240507','sortOrder':'43','description':'Figure 5 NG2-cre, but not NG2-cre ERTM , targeted cells are the source of Scf in the bone marrow (a) Whole-mount sternum from NG2-cre/ iTdTomato/ Scf-GFP mice, anti-VE-cadherin. Representative images from 3 mice. Scale bars, 20 mum. (b) Representative FACS plot showing percentage of NG2-cre/ iTdTomato + cells within CD45 - TER119 - CD31 - Scf-GFP + cells. n\u003d3 mice. (c-e) Analyses of LepR-cre/ Scf fl/- mice. (c) Numbers of HSCs (left) in BM and LSK cells in spleen (right). n\u003d4 mice for cre (-), n\u003d3 mice for cre (+). (d) FACS analyses of HSC (CD150 + CD48 - LSK) cell cycle with Ki-67 and Hoechst 33342 staining. n\u003d5 mice for cre (-), n\u003d6 mice for cre (+). (e) HSC localization relative to arterioles. Error bars: n\u003d3 mice. P value has been calculated using n\u003d272 HSCs for cre (-), 293 HSCs for cre (+) pooled from 3 mice per group. P \u003d0.3402. (f-i) Analyses of NG2-cre/ Scf fl/- mice. (f) Numbers of total BM cells (left) and CD150 + CD48 - LSK HSCs (right) in BM. n\u003d5 mice for cre (-), n\u003d7 mice for cre (+). (g) Percentages of donor-derived cells after competitive reconstitution. n\u003d5 mice for cre (-), n\u003d7 mice for cre (+). (h) FACS analyses of HSC cell cycle with Ki-67 and Hoechst 33342 staining. n\u003d6 mice for cre (-), n\u003d7 mice for cre (+). (i) HSC localization relative to arterioles. Error bars: n\u003d3 mice. P value has been calculated using n\u003d224 HSCs for cre (-), 274 HSCs for cre (+) pooled from 3 mice per group. P \u003d0.2872. (j-l) Analyses of NG2-cre ERTM / Scf fl/- mice. (j) Absolute nu','shortDescription':'Figure 5 NG2-cre, but not NG2-cre ERTM , targeted cells are the source of Scf in the bone marrow (a) Whole-mount sternum from NG2-cre/ iTdTomato/ Scf-GFP mice, anti-VE-cadherin. Representative images from 3 mice. Scale bars, 20 mum. (b) Representative FACS plot showing percentage of NG2-cre/ iTdTomato + cells within CD45 - TER119 - CD31 - Scf-GFP + cells. n\u003d3 mice. (c-e) Analyses of LepR-cre/ Scf fl/- mice.... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Mar 1, 2017, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature cell biology','journalText':'Nature cell biology 2017 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12866_nihms845084f5.jpg','benchSciPubmedId':'28218906'},{'sku':'17-0452-82','imageId':'318755','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_3137_gr6.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_3137_gr6.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_3137_gr6.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_3137_gr6.jpg?time\u003d20240507','sortOrder':'44','description':'Figure 6 Disease Modeling of herPAP Using miPAP iPSCs (A) Number of CD41 + progenitor-derived colonies in methylcellulose-based clonogenic assays employing complete (IL-6, erythropoietin, SCF, IL-3, and supplemented with 20 ng/ml human G-CSF + 20 ng/ml murine GM-CSF) or basic medium (50 ng/ml murine GM-CSF only; independent experiments, n \u003d 3 miPAP1 and 2, n \u003d 2 CD45.1 iPSC, mean +- SD) and representative pictures of colonies. Scale bars, 500 mum. (B) GM-CSF clearance assay comparing miPAP-Mphi with CD45.1(10.3) iPSC-Mphi, BMlin - -Mphi, and no cells incubated with 2 ng/ml GM-CSF: at indicated time points (0, 4, 10, 24, and 30 hr) GM-CSF concentrations in supernatants were analyzed by ELISA, normalized to 0 hr (independent experiments, n \u003d 3 BMlin - and CD45.1 iPSC, n \u003d 2 miPAP1 and 2, mean +- SD). (C and D) Flow cytometry plots of STAT5 phosphorylation levels upon stimulation with mGM-CSF (C) and (D) summary of mean fluorescence intensity (MFI) data (independent experiments, n \u003d 3 BMlin - and CD45.1 iPSC, n \u003d 2 miPAP1 and 2, mean +- SD). ns, not significant; ** p \u003c\u003d 0.01, *** p \u003c\u003d 0.001, **** p \u003c\u003d 0.0001, two-way ANOVA.','shortDescription':'Figure 6 Disease Modeling of herPAP Using miPAP iPSCs (A) Number of CD41 + progenitor-derived colonies in methylcellulose-based clonogenic assays employing complete (IL-6, erythropoietin, SCF, IL-3, and supplemented with 20 ng/ml human G-CSF + 20 ng/ml murine GM-CSF) or basic medium (50 ng/ml murine GM-CSF only; independent experiments, n \u003d 3 miPAP1 and 2, n \u003d 2 CD45.1 iPSC, mean +- SD) and representative p... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Aug 9, 2016, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Stem cell reports','journalText':'Stem cell reports 2016 - ','sourceType':'3','benchsci':true,'imageName':'tfs_3137_gr6.jpg','benchSciPubmedId':'27453007'},{'sku':'17-0452-82','imageId':'361805','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_3129_nihms794951f5.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_3129_nihms794951f5.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_3129_nihms794951f5.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_3129_nihms794951f5.jpg?time\u003d20240507','sortOrder':'45','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Aug 15, 2016, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of immunology (Baltimore, Md. : 1950)','journalText':'Journal of immunology (Baltimore, Md. : 1950) 2016 - ','sourceType':'3','benchsci':true,'imageName':'tfs_3129_nihms794951f5.jpg','benchSciPubmedId':'27357149'},{'sku':'17-0452-82','imageId':'327704','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12858_ncomms9835-f2.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12858_ncomms9835-f2.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12858_ncomms9835-f2.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12858_ncomms9835-f2.jpg?time\u003d20240507','sortOrder':'46','description':'Figure 2 Loss of Gata5 from renal endothelial cells leads to renal alterations. ( a ) GATA5 is expressed in the kidney as assessed by western blot performed on total kidney extracts. ( b ) Gata5 is essentially expressed in the glomeruli as assessed by qPCR on isolated glomeruli (Glo) and microdissected tubules (Tub) from Wt mice kidneys. ( n \u003d3-5 per group). The results are reported as mean+-s.e.m. * P \u003c0.05 versus Gata5 +/+ mice (Mann-Whitney test). ( c , d ) Specific deletion of Gata5 in endothelial cells (e Gata5-null mice) virtually abolished renal and glomerular expression of Gata5 ( n \u003d3 per group). The results are reported as mean+-s.e.m. * P \u003c0.05 versus eGata5 +/+ mice (Mann-Whitney test). ( e ) The expression of the glomerular genes Nphs1 (nephrin) and Nphs2 (podocin) as measured by qPCR ( n \u003d6 per group) was increased in Gata5 -null mice. The results are reported as mean+-s.e.m. * P \u003c0.05 versus Gata5 +/+ mice; *** P \u003c0.005 versus Gata5 +/+ mice ( t -test for nephrin; Mann-Whitney test for podocin). ( f - i ) Absence of Gata5 induces glomerular lesions (sections are stained with periodic acid Schiff; scale bar, 30 mum; n \u003d5 per group) and renal inflammation as assessed by leucocytes CD45 immunostaining (scale bar, 200 mum; n \u003d4 per group). The results are reported as mean+-s.e.m. *** P \u003c0.005 versus Gata5 +/+ mice (Mann-Whitney test). ( j - n ) Deletion of Gata5 from endothelial cells reproduces the renal phenotype of global Gata5 deletion: both Nephs1 and Nphs2 tr','shortDescription':'Figure 2 Loss of Gata5 from renal endothelial cells leads to renal alterations. ( a ) GATA5 is expressed in the kidney as assessed by western blot performed on total kidney extracts. ( b ) Gata5 is essentially expressed in the glomeruli as assessed by qPCR on isolated glomeruli (Glo) and microdissected tubules (Tub) from Wt mice kidneys. ( n \u003d3-5 per group). The results are reported as mean+-s.e.m. * P \u003c0.0... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Nov 30, 2015, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2015 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12858_ncomms9835-f2.jpg','benchSciPubmedId':'26617239'},{'sku':'17-0452-82','imageId':'351328','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12598_JCI83024f4.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12598_JCI83024f4.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12598_JCI83024f4.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12598_JCI83024f4.jpg?time\u003d20240507','sortOrder':'47','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Dec 1, 2015, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'The Journal of clinical investigation','journalText':'The Journal of clinical investigation 2015 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12598_JCI83024f4.jpg','benchSciPubmedId':'26551682'},{'sku':'17-0452-82','imageId':'343920','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_2622_ncomms8450-f7.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_2622_ncomms8450-f7.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_2622_ncomms8450-f7.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_2622_ncomms8450-f7.jpg?time\u003d20240507','sortOrder':'48','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Jun 24, 2015, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nature communications','journalText':'Nature communications 2015 - ','sourceType':'3','benchsci':true,'imageName':'tfs_2622_ncomms8450-f7.jpg','benchSciPubmedId':'26104863'},{'sku':'17-0452-82','imageId':'332916','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12693_2186-3326-76-293-g004AB.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12693_2186-3326-76-293-g004AB.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12693_2186-3326-76-293-g004AB.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12693_2186-3326-76-293-g004AB.jpg?time\u003d20240507','sortOrder':'49','description':'Fig. 4 Analysis of B cell development in bone marrow and spleen. A. FACS analysis of BM B cells. BM cells from WT and RhoF KO mice (6-7 weeks old, n \u003d 5, male: 40%) were stained with antibodies against CD43, B220, BP1, and CD24 and analyzed by flow cytometry. The number shows the percentage (mean +- standard deviation) of the indicated subpopulation within the parent population; Fraction A (germline pro-B cells), fraction B (DJ-rearranged pro-B cells), fraction C (Early pre-B cells), fraction D (Late pre-B cells), fraction E (newly formed B cells), and fraction F (follicular-type recirculating B cells). The figures are representatives of three independent experiments. B. FACS analysis of B cells from the spleen. Splenocytes from WT and RhoF KO mice (6-7 weeks old, n \u003d 6, male: 33%) were stained with antibodies against CD23, CD21, and IgM and analyzed by flow cytometry. The number shows the percentage (mean +- standard deviation) of the indicated subpopulation within the parent population; T1 (Transitional 1), T2 (Transitional 2), Fo (mature follicular B cells), and MZ (MZ B cells). C. The number of B cell subsets in BM was calculated by multiplying the total number of viable (trypan blue negative) BM cells by the fraction of the target population in viable (7AAD negative) cells. The data are shown as mean +- standard deviation (6-7 weeks old, n \u003d 5, male: 40%). White bars: WT. Black bars: RhoF KO. D. The number of B cell subsets in the spleen was also calculated by multiplyin','shortDescription':'Fig. 4 Analysis of B cell development in bone marrow and spleen. A. FACS analysis of BM B cells. BM cells from WT and RhoF KO mice (6-7 weeks old, n \u003d 5, male: 40%) were stained with antibodies against CD43, B220, BP1, and CD24 and analyzed by flow cytometry. The number shows the percentage (mean +- standard deviation) of the indicated subpopulation within the parent population; Fraction A (germline pro-B c... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Aug 1, 2014, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Nagoya journal of medical science','journalText':'Nagoya journal of medical science 2014 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12693_2186-3326-76-293-g004AB.jpg','benchSciPubmedId':'25741038'},{'sku':'17-0452-82','imageId':'347239','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_2678_cdd2014230f5.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_2678_cdd2014230f5.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_2678_cdd2014230f5.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_2678_cdd2014230f5.jpg?time\u003d20240507','sortOrder':'50','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Sep 1, 2015, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell death and differentiation','journalText':'Cell death and differentiation 2015 - ','sourceType':'3','benchsci':true,'imageName':'tfs_2678_cdd2014230f5.jpg','benchSciPubmedId':'25613378'},{'sku':'17-0452-82','imageId':'340237','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_2678_cdd2014230f7.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_2678_cdd2014230f7.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_2678_cdd2014230f7.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_2678_cdd2014230f7.jpg?time\u003d20240507','sortOrder':'51','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Sep 1, 2015, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell death and differentiation','journalText':'Cell death and differentiation 2015 - ','sourceType':'3','benchsci':true,'imageName':'tfs_2678_cdd2014230f7.jpg','benchSciPubmedId':'25613378'},{'sku':'17-0452-82','imageId':'336036','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_2678_cdd2014230f6.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_2678_cdd2014230f6.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_2678_cdd2014230f6.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_2678_cdd2014230f6.jpg?time\u003d20240507','sortOrder':'52','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Sep 1, 2015, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Cell death and differentiation','journalText':'Cell death and differentiation 2015 - ','sourceType':'3','benchsci':true,'imageName':'tfs_2678_cdd2014230f6.jpg','benchSciPubmedId':'25613378'},{'sku':'17-0452-82','imageId':'361763','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12880_JI_1401608_f5.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12880_JI_1401608_f5.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12880_JI_1401608_f5.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12880_JI_1401608_f5.jpg?time\u003d20240507','sortOrder':'53','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Nov 1, 2014, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of immunology (Baltimore, Md. : 1950)','journalText':'Journal of immunology (Baltimore, Md. : 1950) 2014 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12880_JI_1401608_f5.jpg','benchSciPubmedId':'25238757'},{'sku':'17-0452-82','imageId':'361743','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12878_pone0091373s001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12878_pone0091373s001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12878_pone0091373s001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12878_pone0091373s001.jpg?time\u003d20240507','sortOrder':'54','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Dec 22, 2014, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'PloS one','journalText':'PloS one 2014 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12878_pone0091373s001.jpg','benchSciPubmedId':'24651473'},{'sku':'17-0452-82','imageId':'344436','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_2211_nihms562570f1.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_2211_nihms562570f1.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_2211_nihms562570f1.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_2211_nihms562570f1.jpg?time\u003d20240507','sortOrder':'55','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Apr 1, 2014, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of immunology (Baltimore, Md. : 1950)','journalText':'Journal of immunology (Baltimore, Md. : 1950) 2014 - ','sourceType':'3','benchsci':true,'imageName':'tfs_2211_nihms562570f1.jpg','benchSciPubmedId':'24591377'},{'sku':'17-0452-82','imageId':'339933','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_2053_auto-9-1009-g2.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_2053_auto-9-1009-g2.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_2053_auto-9-1009-g2.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_2053_auto-9-1009-g2.jpg?time\u003d20240507','sortOrder':'56','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Jul 1, 2013, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Autophagy','journalText':'Autophagy 2013 - ','sourceType':'3','benchsci':true,'imageName':'tfs_2053_auto-9-1009-g2.jpg','benchSciPubmedId':'23615463'},{'sku':'17-0452-82','imageId':'346022','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_1947_pgen1003226s005.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_1947_pgen1003226s005.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_1947_pgen1003226s005.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_1947_pgen1003226s005.jpg?time\u003d20240507','sortOrder':'57','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Jun 13, 2013, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'PLoS genetics','journalText':'PLoS genetics 2013 - ','sourceType':'3','benchsci':true,'imageName':'tfs_1947_pgen1003226s005.jpg','benchSciPubmedId':'23505375'},{'sku':'17-0452-82','imageId':'355639','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12671_nihms411554f3.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12671_nihms411554f3.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12671_nihms411554f3.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12671_nihms411554f3.jpg?time\u003d20240507','sortOrder':'58','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Dec 1, 2012, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of immunology (Baltimore, Md. : 1950)','journalText':'Journal of immunology (Baltimore, Md. : 1950) 2012 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12671_nihms411554f3.jpg','benchSciPubmedId':'23087406'},{'sku':'17-0452-82','imageId':'355597','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12671_nihms411554f2.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12671_nihms411554f2.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12671_nihms411554f2.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12671_nihms411554f2.jpg?time\u003d20240507','sortOrder':'59','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Dec 1, 2012, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of immunology (Baltimore, Md. : 1950)','journalText':'Journal of immunology (Baltimore, Md. : 1950) 2012 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12671_nihms411554f2.jpg','benchSciPubmedId':'23087406'},{'sku':'17-0452-82','imageId':'344143','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_1854_nihms-390477-f0005.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_1854_nihms-390477-f0005.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_1854_nihms-390477-f0005.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_1854_nihms-390477-f0005.jpg?time\u003d20240507','sortOrder':'60','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Sep 1, 2012, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Journal of immunology (Baltimore, Md. : 1950)','journalText':'Journal of immunology (Baltimore, Md. : 1950) 2012 - ','sourceType':'3','benchsci':true,'imageName':'tfs_1854_nihms-390477-f0005.jpg','benchSciPubmedId':'22826323'},{'sku':'17-0452-82','imageId':'322582','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12579_pone0022043g004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12579_pone0022043g004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12579_pone0022043g004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12579_pone0022043g004.jpg?time\u003d20240507','sortOrder':'61','description':'Figure 4 Lung leukocyte infiltration during influenza infection is comparable between PAD4 WT and KO mice. Experimental setup as described in Figure 2 . (A-C) Five mice per group were analyzed at d3 or d7 post infection. Leukocytes were isolated from infected lungs. (A) Total cell numbers of lung-infiltrating leukocytes at d3 and d7 p.i. Each symbol represents an individual mouse, filled squares represent PAD4 WT, open squares depict PAD4 KO mice. (B+C) The subsets of infiltrating leukocytes were enumerated by flow cytometry both at d3 p.i. (B) and d7 p.i. (C). Gated populations are indicated at the bottom of the graph. Total numbers of infiltrating cells are shown. WT mice are depicted in white bars, KO mice as grey bars. Bars represent mean + SEM. (D) Lungs for histological examination were harvested at d8 p.i. (5 mice/group). Leukocyte infiltration was assessed on H\u0026E stained paraffin sections. Sections from two representative mice per group are shown. The scale bar indicates 200 um. Data is representative of two independent experiments.','shortDescription':'Figure 4 Lung leukocyte infiltration during influenza infection is comparable between PAD4 WT and KO mice. Experimental setup as described in Figure 2 . (A-C) Five mice per group were analyzed at d3 or d7 post infection. Leukocytes were isolated from infected lungs. (A) Total cell numbers of lung-infiltrating leukocytes at d3 and d7 p.i. Each symbol represents an individual mouse, filled squares represent P... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Nov 15, 2011, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'PloS one','journalText':'PloS one 2011 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12579_pone0022043g004.jpg','benchSciPubmedId':'21779371'},{'sku':'17-0452-82','imageId':'350693','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_1691_nihms294931f3.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_1691_nihms294931f3.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_1691_nihms294931f3.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_1691_nihms294931f3.jpg?time\u003d20240507','sortOrder':'62','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Feb 25, 2011, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Immunity','journalText':'Immunity 2011 - ','sourceType':'3','benchsci':true,'imageName':'tfs_1691_nihms294931f3.jpg','benchSciPubmedId':'21333553'},{'sku':'17-0452-82','imageId':'350690','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_1691_nihms294931f2.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_1691_nihms294931f2.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_1691_nihms294931f2.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_1691_nihms294931f2.jpg?time\u003d20240507','sortOrder':'63','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Feb 25, 2011, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Immunity','journalText':'Immunity 2011 - ','sourceType':'3','benchsci':true,'imageName':'tfs_1691_nihms294931f2.jpg','benchSciPubmedId':'21333553'},{'sku':'17-0452-82','imageId':'350658','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_1483_zh80170934270002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_1483_zh80170934270002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_1483_zh80170934270002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_1483_zh80170934270002.jpg?time\u003d20240507','sortOrder':'64','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'May 7, 2009, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Blood','journalText':'Blood 2009 - ','sourceType':'3','benchsci':true,'imageName':'tfs_1483_zh80170934270002.jpg','benchSciPubmedId':'19196865'},{'sku':'17-0452-82','imageId':'347282','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_1483_zh80170934270001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_1483_zh80170934270001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_1483_zh80170934270001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_1483_zh80170934270001.jpg?time\u003d20240507','sortOrder':'65','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'May 7, 2009, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Blood','journalText':'Blood 2009 - ','sourceType':'3','benchsci':true,'imageName':'tfs_1483_zh80170934270001.jpg','benchSciPubmedId':'19196865'},{'sku':'17-0452-82','imageId':'327138','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12877_pone0001911g002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12877_pone0001911g002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12877_pone0001911g002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12877_pone0001911g002.jpg?time\u003d20240507','sortOrder':'66','description':'Figure 2 Splenic T cell hyperplasia and T cell size in p27 -/- Lck-Bcl-2 mice. A) Total splenic cells from mice of the indicated genotypes were isolated and stained with anti-B220-PE and anti-CD3-FITC antibodies as described in the Materials and Methods . The percentage of CD3-positive cells and the total number of splenic T cells (total # of splenic cells X %CD3) is shown. The data are representative of at least three mice from each genotype. B) The Mean Forward Scatter of CD3 positive splenic T cells was determined by staining with an anti-CD3 antibody as described in the Materials and Methods . The Mean+-SD of at least 5 mice is shown for the genotypes indicated. * P\u003c0.01 versus both the p27 +/- and p27 -/- mice using the unpaired Students T test. The p27 +/- Lck-Bcl-2 mice were not significantly different than the P27 -/- Lck-Bcl-2 mice (P \u003d 0.89).','shortDescription':'Figure 2 Splenic T cell hyperplasia and T cell size in p27 -/- Lck-Bcl-2 mice. A) Total splenic cells from mice of the indicated genotypes were isolated and stained with anti-B220-PE and anti-CD3-FITC antibodies as described in the Materials and Methods . The percentage of CD3-positive cells and the total number of splenic T cells (total # of splenic cells X %CD3) is shown. The data are representative of at... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Apr 2, 2008, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'PloS one','journalText':'PloS one 2008 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12877_pone0001911g002.jpg','benchSciPubmedId':'18382684'},{'sku':'17-0452-82','imageId':'347458','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12876_zmb0170769470004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12876_zmb0170769470004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12876_zmb0170769470004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12876_zmb0170769470004.jpg?time\u003d20240507','sortOrder':'67','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Sep 1, 2007, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Molecular and cellular biology','journalText':'Molecular and cellular biology 2007 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12876_zmb0170769470004.jpg','benchSciPubmedId':'17591700'},{'sku':'17-0452-82','imageId':'347433','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12876_zmb0170769470003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12876_zmb0170769470003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12876_zmb0170769470003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12876_zmb0170769470003.jpg?time\u003d20240507','sortOrder':'68','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Sep 1, 2007, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Molecular and cellular biology','journalText':'Molecular and cellular biology 2007 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12876_zmb0170769470003.jpg','benchSciPubmedId':'17591700'},{'sku':'17-0452-82','imageId':'347406','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12876_zmb0170769470002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12876_zmb0170769470002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12876_zmb0170769470002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12876_zmb0170769470002.jpg?time\u003d20240507','sortOrder':'69','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Sep 1, 2007, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Molecular and cellular biology','journalText':'Molecular and cellular biology 2007 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12876_zmb0170769470002.jpg','benchSciPubmedId':'17591700'},{'sku':'17-0452-82','imageId':'347381','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_12876_zmb0170769470001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_12876_zmb0170769470001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_12876_zmb0170769470001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_12876_zmb0170769470001.jpg?time\u003d20240507','sortOrder':'70','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Sep 1, 2007, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Molecular and cellular biology','journalText':'Molecular and cellular biology 2007 - ','sourceType':'3','benchsci':true,'imageName':'tfs_12876_zmb0170769470001.jpg','benchSciPubmedId':'17591700'},{'sku':'17-0452-82','imageId':'358494','imageUrl':'https://www.thermofisher.com/antibody/images/650/15045282-17030619-CD45R-B220-zmb0240664150005.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/15045282-17030619-CD45R-B220-zmb0240664150005.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/15045282-17030619-CD45R-B220-zmb0240664150005.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/15045282-17030619-CD45R-B220-zmb0240664150005.jpg?time\u003d20240507','sortOrder':'71','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Dec 1, 2006, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Molecular and cellular biology','journalText':'Molecular and cellular biology 2006 - ','sourceType':'3','benchsci':true,'imageName':'15045282-17030619-CD45R-B220-zmb0240664150005.jpg','benchSciPubmedId':'17030619'},{'sku':'17-0452-82','imageId':'347374','imageUrl':'https://www.thermofisher.com/antibody/images/650/15045282-17030619-CD45R-B220-zmb0240664150003.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/15045282-17030619-CD45R-B220-zmb0240664150003.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/15045282-17030619-CD45R-B220-zmb0240664150003.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/15045282-17030619-CD45R-B220-zmb0240664150003.jpg?time\u003d20240507','sortOrder':'72','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Dec 1, 2006, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Molecular and cellular biology','journalText':'Molecular and cellular biology 2006 - ','sourceType':'3','benchsci':true,'imageName':'15045282-17030619-CD45R-B220-zmb0240664150003.jpg','benchSciPubmedId':'17030619'},{'sku':'17-0452-82','imageId':'335983','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_1365_zmb0240664150002.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_1365_zmb0240664150002.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_1365_zmb0240664150002.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_1365_zmb0240664150002.jpg?time\u003d20240507','sortOrder':'73','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Dec 1, 2006, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Molecular and cellular biology','journalText':'Molecular and cellular biology 2006 - ','sourceType':'3','benchsci':true,'imageName':'tfs_1365_zmb0240664150002.jpg','benchSciPubmedId':'17030619'},{'sku':'17-0452-82','imageId':'335961','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_1365_zmb0240664150001.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_1365_zmb0240664150001.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_1365_zmb0240664150001.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_1365_zmb0240664150001.jpg?time\u003d20240507','sortOrder':'74','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Dec 1, 2006, 5:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Molecular and cellular biology','journalText':'Molecular and cellular biology 2006 - ','sourceType':'3','benchsci':true,'imageName':'tfs_1365_zmb0240664150001.jpg','benchSciPubmedId':'17030619'},{'sku':'17-0452-82','imageId':'354119','imageUrl':'https://www.thermofisher.com/antibody/images/650/11045282-10454544-CD45R-B220-mb099028905a.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/11045282-10454544-CD45R-B220-mb099028905a.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/11045282-10454544-CD45R-B220-mb099028905a.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/11045282-10454544-CD45R-B220-mb099028905a.jpg?time\u003d20240507','sortOrder':'75','description':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','shortDescription':'Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry','altTag':'CD45R (B220) Antibody in Flow Cytometry (Flow)','title':'CD45R (B220) Antibody (17-0452-82) in Flow','appAbv':'Flow','dateTime':'Sep 1, 1999, 4:00:00 AM','appName':'Flow Cytometry','type':'Published Figures','journalTitle':'Molecular and cellular biology','journalText':'Molecular and cellular biology 1999 - ','sourceType':'3','benchsci':true,'imageName':'11045282-10454544-CD45R-B220-mb099028905a.jpg','benchSciPubmedId':'10454544'},{'sku':'17-0452-82','imageId':'933639','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_19026_cancers-13-05019-g004.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_19026_cancers-13-05019-g004.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_19026_cancers-13-05019-g004.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_19026_cancers-13-05019-g004.jpg?time\u003d20240507','sortOrder':'76','description':'Figure 4 Proof-of-mechanism study for TAX2 use as an anti-tumor immunomodulatory drug. The effects of TAX2 peptide treatment on the activation of an anti-tumor immune response were investigated in two syngeneic models of epithelial ovarian carcinoma. We inoculated 5 x 10 6 ID8 cells either subcutaneously or intraperitoneally to C57BL/6JRj mice in order to mimic primary tumor growth ( a - h ) and metastatic dissemination (peritoneal carcinosis, i - l ), respectively. TAX2 treatments (30 mg * kg -1 BW) vs. vehicle injections (0.9% NaCl) were performed thrice weekly for 4 and 8 weeks for the s.c. and i.p. ID8 models, respectively ( n \u003d 11 per group for both models). ( a - h ) IHC staining of s.c. ovarian carcinoma allografts for the analysis of the vascular/lymphovascular features, as well as immune-cell-infiltration profile. ( a ) Representative microphotograph for CD31 immunostaining of intra-tumor vascular structures. Histogram displays results of automated quantification for the percent of CD31-positive pixels across the whole tumor section (mean +- SEM, Mann-Whitney U test; n.s., not significant). ( b ) Lymphatic vessel density analysis. Microscopic views are shown, while histogram displays the number of Lyve-1-positive functional lymphatic vessels in 5 high power fields (HPF), as determined by a pathologist who was blinded to the treatment (mean +- SEM, Mann-Whitney U test, * p \u003c 0.05). ( c - f ) Macroscopic views (x20 magnification) of s.c. tumor allograft sections after','shortDescription':'Figure 4 Proof-of-mechanism study for TAX2 use as an anti-tumor immunomodulatory drug. The effects of TAX2 peptide treatment on the activation of an anti-tumor immune response were investigated in two syngeneic models of epithelial ovarian carcinoma. We inoculated 5 x 10 6 ID8 cells either subcutaneously or intraperitoneally to C57BL/6JRj mice in order to mimic primary tumor growth ( a - h ) and metastatic ... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody in Immunohistochemistry (IHC)','title':'CD45R (B220) Antibody (17-0452-82) in IHC','appAbv':'IHC','dateTime':'Oct 7, 2021, 4:00:00 AM','appName':'Immunohistochemistry','type':'Published Figures','journalTitle':'Cancers','journalText':'Cancers 2021 - ','sourceType':'3','benchsci':true,'imageName':'tfs_19026_cancers-13-05019-g004.jpg','benchSciPubmedId':'34638503'}],'Advanced Verification':[{'sku':'17-0452-82','imageId':'132171','imageUrl':'https://www.thermofisher.com/antibody/images/650/17045282-CD45R-(B220)-RA3-6B2-RE-AV-20170920122035.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/17045282-CD45R-(B220)-RA3-6B2-RE-AV-20170920122035.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/17045282-CD45R-(B220)-RA3-6B2-RE-AV-20170920122035.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/17045282-CD45R-(B220)-RA3-6B2-RE-AV-20170920122035.jpg?time\u003d20240507','sortOrder':'1','description':'Staining of mouse splenocytes and bone marrow cells. As expected based on known relative expression patterns, CD45R (B220) clone RA3-6B2 stains subsets in both the splenocytes gate and the bone marrow lymphoid gate but not the bone marrow myeloid gate. Details: Balb/c bone marrow cells (left) and splenocytes (middle) were surface stained with CD45R (B220, clone RA3-6B2) followed by staining with 7-AAD. Viable bone marrow cells in the lymphoid (blue histogram) and myeloid (purple histogram) gates and viable splenocytes (orange histogram) were used for analysis. {RE}','shortDescription':'Staining of mouse splenocytes and bone marrow cells. As expected based on known relative expression patterns, CD45R (B220) clone RA3-6B2 stains subsets in both the splenocytes gate and the bone marrow lymphoid gate but not the bone marrow myeloid gate. Details: Balb/c bone marrow cells (left) and splenocytes (middle) were surface stained with CD45R (B220, clone RA3-6B2) followed by staining with 7-AAD. Viab... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody','title':'CD45R (B220) Antibody (17-0452-82)','appAbv':'RE','appName':'Relative expression','type':'Advanced Verification','journalText':'','sourceType':'2','benchsci':false,'imageName':'17045282-CD45R-(B220)-RA3-6B2-RE-AV-20170920122035.jpg','benchSciPubmedId':'0'},{'sku':'17-0452-82','imageId':'863196','imageUrl':'https://www.thermofisher.com/antibody/images/650/tfs_14705_MMR-17-06-7701-g03.jpg?time\u003d20240507','imageUrlFullSize':'https://www.thermofisher.com/antibody/images/650/tfs_14705_MMR-17-06-7701-g03.jpg?time\u003d20240507','imageUrlMidSize':'https://www.thermofisher.com/antibody/images/250/tfs_14705_MMR-17-06-7701-g03.jpg?time\u003d20240507','imageUrlSmallSize':'https://www.thermofisher.com/antibody/images/150/tfs_14705_MMR-17-06-7701-g03.jpg?time\u003d20240507','sortOrder':'3','description':'Figure 4. MSC-CM treatment alleviates mature B lymphocyte infiltration into the kidneys following UUO. (A) Representative images of Sham + PBS, Sham + MSC-CM, UUO + PBS and UUO + MSC-CM mice 3 days following surgery. Scale bar\u003d50 um. Data are presented as the mean +- standard deviation (n\u003d6-7). (B) Representative flow cytometry images of renal B220 + CD19 + B lymphocyte cytometry of Sham + PBS, Sham + MSC-CM, UUO + PBS and UUO + MSC-CM mice 3 days following surgery. (C) Quantitative analysis of B220 staining and (D) quantitative analysis of renal B220 + CD19 + B lymphocyte cytometry. Data are presented as the means +- standard deviation (n\u003d6). *P\u003c0.05 vs. Sham + PBS group; $ P\u003c0.05 vs. UUO + PBS group. MSC-CM, mesenchymal stem cell-conditioned media; Sham + PBS, sham-operated and PBS treated; Sham + MSC-CM, sham-operated and MSC-CM treated; UUO, unilateral ureteral obstruction; UUO + PBS, UUO model and PBS treated; UUO + MSC-CM, UUO model and MSC-CM treated. {TM}','shortDescription':'Figure 4. MSC-CM treatment alleviates mature B lymphocyte infiltration into the kidneys following UUO. (A) Representative images of Sham + PBS, Sham + MSC-CM, UUO + PBS and UUO + MSC-CM mice 3 days following surgery. Scale bar\u003d50 um. Data are presented as the mean +- standard deviation (n\u003d6-7). (B) Representative flow cytometry images of renal B220 + CD19 + B lymphocyte cytometry of Sham + PBS, Sham + MSC-C... \u003ca href\u003d\'#\' class\u003d\'images-view-more-text\' \u003eView More\u003c/a\u003e','altTag':'CD45R (B220) Antibody','title':'CD45R (B220) Antibody (17-0452-82)','appAbv':'TM','appName':'Cell treatment','type':'Advanced Verification','journalText':'','sourceType':'7','benchsci':true,'imageName':'tfs_14705_MMR-17-06-7701-g03.jpg','benchSciPubmedId':'0'}]}" image-displayed-id="'91021'" product-sub-type="'antibody_primary'" prod-type="'antibody'" page-type="PDP" product-id="'17-0452-82'"> <div class="tabs"> <ul class="nav nav-pills"> <li class="tab" onclick="window.THERMO_FISHER.inp.onTabClick(event, this)" data-tabname="Antibody Testing Data"> <a class="tab-text"> Antibody Testing Data (1) </a> </li> <li class="tab" onclick="window.THERMO_FISHER.inp.onTabClick(event, this)" data-tabname="Published Figures"> <a class="tab-text"> Published Figures (73) </a> </li> 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icon-gallery-arrow-right"> </div> </div> </div> <div class="media-display" ng-if="!$ctrl.isMobileSmallTabletScreen()"> <img id="media-image" class="image" ng-show="!$ctrl.isVideo" src="https://www.thermofisher.com/antibody/images/650/17-0452-82_CD45R-B220_Flow_1-20170119083539.jpg?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody in Flow Cytometry (Flow)" longdesc="https://www.thermofisher.com/antibody/images/650/17-0452-82_CD45R-B220_Flow_1-20170119083539.jpg?time=20240507?time=20240507" onerror="javascript:imageErrorHandler.call(this, event);" > <div class="hover-text" ng-show="!$ctrl.isVideo"> <a href="javascript:return false;" onclick="window.THERMO_FISHER.inp.openImageGalleryModal(event, this)" aria-label="image-link"> <div class="rectangle"> <div class="expand-logo-rightcorner"> <?xml version="1.0" encoding="utf-8"?>  <svg width="19px" height="19px" version="1.1" id="Layer_1" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" x="0px" y="0px" viewBox="0 0 22 22" style="enable-background:new 0 0 22 22;" xml:space="preserve"> <style type="text/css"> .st0{fill-rule:evenodd;clip-rule:evenodd;fill:#222222;} </style> <title>Group 53</title> <desc>Created with Sketch.</desc> <g id="Symbols"> <g id="rollover-expand-icon" transform="translate(-8.000000, -8.000000)"> <g id="Group-48"> <g id="Group-53" transform="translate(8.000000, 8.000000)"> <g id="Group-49" transform="translate(0.000000, 0.000000)"> <g id="Group-54"> <g id="Group-55" transform="translate(0.000000, -0.000000)"> <path id="Fill-1" class="st0" d="M21.9,14.6h-2.2c0,1,0,1.9,0,2.9c0,0.2,0,0.4,0,0.6c-0.1-0.1-0.2-0.2-0.3-0.2 c-1.3-1.3-2.7-2.7-4-4l-1.6,1.5c1.3,1.4,2.7,2.7,4,4.1c0.1,0.1,0.1,0.2,0.3,0.3c-0.2,0-0.3,0-0.4,0c-1,0-2.1,0-3.1,0V22 c2.3,0,4.8,0,7.1,0.1c0.1,0,0.2,0,0.3,0c0-0.5-0.1-0.9-0.1-1.3C21.9,18.7,21.9,16.6,21.9,14.6z"/> <path id="Fill-4" class="st0" d="M1.3,21.9c1.9,0,4,0,6,0v-2.2c-1,0-1.9,0-2.9,0c-0.2,0-0.4,0-0.6,0C3.9,19.6,4,19.5,4,19.4 c1.3-1.3,2.7-2.7,3.9-4l-1.5-1.6c-1.3,1.3-2.7,2.7-4,4c-0.1,0.1-0.2,0.1-0.3,0.3c0-0.2,0-0.3,0-0.4c0-1,0-2.1,0-3.1h-2.2 c0,2.3,0,4.7-0.1,7c0,0.1,0,0.2,0,0.3C0.5,21.9,0.9,21.9,1.3,21.9"/> <path id="Fill-7" class="st0" d="M0.1,1.3c0,1.9,0,4,0,6h2.2c0-1,0-1.9,0-2.9c0-0.2,0-0.4,0-0.6C2.4,3.9,2.5,4,2.5,4.1 c1.3,1.3,2.7,2.7,4,3.9l1.6-1.5c-1.3-1.3-2.7-2.7-4-4C4,2.4,3.9,2.3,3.8,2.2c0.2,0,0.3,0,0.4,0c1,0,2.1,0,3.1,0V0 C5,0,2.6,0,0.3,0C0.2,0,0.1,0,0,0C0,0.5,0.1,0.9,0.1,1.3"/> <path id="Fill-10" class="st0" d="M20.7,0.1c-1.9,0-4,0-6,0v2.1c1,0,1.9,0,2.9,0c0.2,0,0.4,0,0.6,0C18,2.4,18,2.5,17.9,2.6 c-1.3,1.3-2.7,2.6-3.9,3.9L15.5,8c1.3-1.3,2.7-2.6,4-4c0.1-0.1,0.2-0.1,0.3-0.2c0,0.2,0,0.3,0,0.4c0,1,0,2,0,3.1H22 c0-2.3,0-4.7,0.1-6.9c0-0.1,0-0.2,0-0.3C21.5,0.1,21.1,0.1,20.7,0.1"/> </g> </g> </g> </g> </g> </g> </g> </svg> </div> </div> </a> </div> </div> <div class="media-desc"> <div class="gallery-count"> <p> FIGURE: <span class="current-img"> 1 </span> / <span class="img-total-count"> 76</span></p> </div> <div class = "verification-certificate hide" > <span class="icon-certification"></span> <span class="adv-cert-text">{{ $ctrl.currentElement.advancedVerification.fullName }}</span> <div class="cert-provider">{{ $ctrl.currentElement.advancedVerification.text }}</div> </div> <h2 class="product-name" ng-show="!$ctrl.isVideo"> CD45R (B220) Antibody (17-0452-82) in Flow </h2> <div ng-show="!$ctrl.isVideo"> <div class="image-desc"> <div class="product-desc-text viewing-more-long-description"> <span class="image-journal-text" > </span> <span class="short-desc"> Staining of C57Bl/6 splenocytes with Anti-Mouse CD3 PerCP-eFluor® 710 (Product # 46-0032-82) and 0.125 µg of Rat IgG2a K Isotype Control APC (Product # 17-4321-81) (left) or 0.125 µg of Anti-Human/Mouse CD45R (B220) APC (right). Cells in the lymphocyte gate were used for analysis. </span> <span class="verification-info hide" ng-if="$ctrl.hasVerificationMethod"> <a rel="nofollow" ng-href="{{$ctrl.currentElement.advancedVerification.uri}}" >{{ $ctrl.currentElement.advancedVerification.fullName }} validation info.</a> </span> <a href="#" class="images-view-more-text hide" ng-if="$ctrl.showViewMore" onclick="window.THERMO_FISHER.inp.openImageGalleryModal(event, this)"> View more </a> </div> </div> <div class="img-desc-footer"> <div class="benchsci-pubmed-footer"> <div ng-cloak ng-if="$ctrl.currentElement.benchsci || $ctrl.sourceType === '3'" class="images-benchsci-footer"> <div class="images-benchsci-link" tabindex="0"> <span>Published figure supplied by</span> <span class="icon-benchsci-logo"> <svg id="Layer_1" data-name="Layer 1" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 89.75 23.21"><defs><style>.cls-1{fill:#222222;}</style></defs><title>benchsci-logo</title><g id="logo-blue-copy-3"><g id="logo-blue-copy-2"><path id="path14" class="cls-1" d="M34.54,11.49a2.45,2.45,0,0,0,1.59-2.34c0-1.69-1.21-2.94-3.32-2.94H28.88v10.9h4.21a3.06,3.06,0,0,0,3.37-3A2.57,2.57,0,0,0,34.54,11.49ZM31,8h1.49c1,0,1.57.53,1.57,1.36a1.36,1.36,0,0,1-1.55,1.37H31Zm1.72,7.35H31V12.47h1.75a1.42,1.42,0,0,1,1.62,1.46C34.34,14.79,33.72,15.34,32.69,15.34Z"/><path id="path16" class="cls-1" d="M41.34,9.32a3.8,3.8,0,0,0-3.72,4,3.83,3.83,0,0,0,3.91,4.05A3.39,3.39,0,0,0,45,15l-1.71-.51a1.67,1.67,0,0,1-1.72,1.15,1.85,1.85,0,0,1-1.91-1.73H45s0-.34,0-.63C45.09,10.81,43.69,9.32,41.34,9.32Zm-1.66,3.15A1.63,1.63,0,0,1,41.37,11a1.52,1.52,0,0,1,1.69,1.49Z"/><path id="path18" class="cls-1" d="M50.58,9.35a2.48,2.48,0,0,0-2.18,1.14v-1h-2v7.57h2.05V12.75a1.42,1.42,0,0,1,1.41-1.57,1.34,1.34,0,0,1,1.4,1.52v4.42h2V12.35C53.32,10.68,52.46,9.35,50.58,9.35Z"/><path id="path20" class="cls-1" d="M58.2,15.47a1.94,1.94,0,0,1-1.94-2.14,1.92,1.92,0,0,1,1.91-2.12,1.64,1.64,0,0,1,1.67,1.27l1.83-.61a3.45,3.45,0,0,0-3.55-2.55,3.83,3.83,0,0,0-2.82,1.16,3.88,3.88,0,0,0-1.1,2.85,3.9,3.9,0,0,0,4,4,3.5,3.5,0,0,0,3.53-2.55l-1.8-.6A1.72,1.72,0,0,1,58.2,15.47Z"/><path id="path22" class="cls-1" d="M67,9.35a2.72,2.72,0,0,0-2.07.83V6h-2V17.12h2V12.67a1.43,1.43,0,0,1,1.42-1.48,1.34,1.34,0,0,1,1.4,1.53v4.41h2V12.35A2.67,2.67,0,0,0,67,9.35Z"/><path id="path24" class="cls-1" d="M75.82,11.05l-1.63-.35a1.58,1.58,0,0,1-1.4-1.59A1.93,1.93,0,0,1,74.9,7.3a2.21,2.21,0,0,1,2.3,1.86l1.36-.48a3.73,3.73,0,0,0-7.29.54,3,3,0,0,0,2.67,3l1.55.33c1.09.24,1.63.91,1.63,1.7,0,.95-.74,1.74-2.25,1.74a2.51,2.51,0,0,1-1.79-.63,2.45,2.45,0,0,1-.82-1.71l-1.45.46a3.79,3.79,0,0,0,4.08,3.24c2.32,0,3.76-1.52,3.76-3.22C78.65,12.59,77.63,11.45,75.82,11.05Z"/><path id="path26" class="cls-1" d="M83.25,16A2.33,2.33,0,0,1,81,13.41a2.31,2.31,0,0,1,2.24-2.59,1.93,1.93,0,0,1,2,1.57l1.31-.55a3.22,3.22,0,0,0-3.29-2.35,3.7,3.7,0,0,0-3.72,3.92,3.75,3.75,0,0,0,3.74,3.94A3.41,3.41,0,0,0,86.59,15l-1.28-.55A2,2,0,0,1,83.25,16Z"/><path id="path28" class="cls-1" d="M88.69,5.89a1,1,0,1,0,.75.29A1,1,0,0,0,88.69,5.89Z"/><polygon id="rect30" class="cls-1" points="87.99 9.72 89.42 9.72 89.42 17.11 87.99 17.11 87.99 9.72"/><path id="path32" class="cls-1" d="M14.58,8.87A4.1,4.1,0,0,0,15.8,6H14.31a2.62,2.62,0,0,1-.76,1.87L11.66,9.7l-2-2A2.61,2.61,0,0,1,9,6H7.53A4.09,4.09,0,0,0,8.74,8.87l1.87,1.87L8.74,12.61a4.08,4.08,0,0,0-1.21,2.92v2.29H9.18V16.73h1.66v1.09h1.64V16.73h1.65v1.09H15.8V15.53a4.11,4.11,0,0,0-1.21-2.92l-1.38-1.36-1,1.05,1.37,1.36a2.63,2.63,0,0,1,.77,1.58H9a2.68,2.68,0,0,1,.76-1.58Z"/><path id="path34" class="cls-1" d="M11.61,23.21a11.61,11.61,0,1,1,11.6-11.6A11.6,11.6,0,0,1,11.61,23.21Zm0-21.89A10.29,10.29,0,1,0,21.9,11.61,10.28,10.28,0,0,0,11.61,1.32Z"/></g></g></svg> </span> <span id="bechsci-tooltip-{{$ctrl.productId}}" class="bechsci-tooltip-icon" data-toggle="tooltip" ng-click="$ctrl.showBechSciTooltip()" close-tooltip="$ctrl.closeBechSciTooltip()" data-html="true" title="Clicking this link will redirect you to the <a href='https://www.benchsci.com/' target='_blank'> BenchSci</a> website that provides third-party scientific content. 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Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="335961" data-index="71"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_1365_zmb0240664150001.jpg?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="354119" data-index="72"> <img src="https://www.thermofisher.com/antibody/images/150/11045282-10454544-CD45R-B220-mb099028905a.jpg?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="933639" data-index="73"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_19026_cancers-13-05019-g004.jpg?time=20240507" alt="CD45R (B220) Antibody in Immunohistochemistry (IHC)"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="132171" data-index="74"> <img src="https://www.thermofisher.com/antibody/images/150/17045282-CD45R-(B220)-RA3-6B2-RE-AV-20170920122035.jpg?time=20240507" alt="CD45R (B220) Antibody"/> </div> <div image-gallery-fade-server-side class="img-flipcard" onclick="window.THERMO_FISHER.inp.onClickFilmstripItem(event, this)" data-imgid="863196" data-index="75"> <img src="https://www.thermofisher.com/antibody/images/150/tfs_14705_MMR-17-06-7701-g03.jpg?time=20240507" alt="CD45R (B220) Antibody"/> </div> </div> </div> </div> </div> <noscript> <div itemscope itemtype="http://schema.org/ImageGallery"> <h2>Product Image Gallery</h2> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/17-0452-82_CD45R-B220_Flow_1-20170119083539.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Staining of C57Bl/6 splenocytes with Anti-Mouse CD3 PerCP-eFluor® 710 (Product # 46-0032-82) and 0.125 µg of Rat IgG2a K Isotype Control APC (Product # 17-4321-81) (left) or 0.125 µg of Anti-Human/Mouse CD45R (B220) APC (right). Cells in the lymphocyte gate were used for analysis.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_29067_41586_2023_6436_Fig10_ESM.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Extended Data Fig. 5 Validation of PF4-mediated changes to spleen-derived immune cells in aged mice. (a-c) Flow cytometry gating strategy for the identification of CD45+ myeloid (lin-) and lymphoid (lin+) cells, neutrophils (CD45+, lin-, Ly6G+), and macrophages (CD45+, lin-, F4/80+, CD11b+) in the aged spleen. (b) Comparison of the ratio of myeloid cells to lymphoid cells in the spleen of saline and PF4 treated aged mice (n = 8 saline; 9 PF4 mice). (c) Comparison of the relative populations of neutrophils and macrophages in the spleen (n = 8 saline; 9 PF4 mice). (d) qPCR of inflammation-related genes relative to Gapdh in the aged spleen (n = 12 saline; 11 PF4 mice). (e-f) Flow cytometry gating strategy for the identification of CD4+ T cells, CD8+ T cells, and CD8+ T effector memory cells (CD45+, CD3+, CD8+, CD44 HI , CD62L LO) in the aged spleen. (f) Comparison of the relative populations of T cells in the spleen (n = 8 mice/group). (g) Schematic of aged T cell isolation, activation, and treatment with vehicle or PF4 (1 mug mL -1). (h,i) Flow cytometry gating strategy for the identification of the exhaustion marker PD1 in CD4+ and CD8+ T cells following in vitro activation of aged T cells. (i) Quantification of PD-1 expression in CD4+ and CD8+ T cells by flow cytometry (n = 6 biologically independent samples/group). Data shown as mean +- s.e.m. ; two-tailed unpaired t -test (b,c,d,f), two-way ANOVA with a Sidak post hoc test (i). Source data</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_24533_41419_2022_5171_Fig7_HTML.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Lenvatinib insignificantly affects the immune microenvironment in NPC in humanized NSG mice. A Schematic diagram of the establishment of humanized NSG mice. B Representative FACS analysis of human CD45 + cells in mouse peripheral blood. Human CD45 + cell percentage greater than 25% was considered successful in modeling. C - E Tumor growth ( C ), tumor weights ( D ) were measured in vehicle-, anti-VEGF-, and lenvatinib-treated NPC tumors. The tumor inhibition ratio were calculated ( E ) ( n = 3 samples per group). F Representative micrographs of Ki67 + proliferative cells and cleaved caspase-3 + apoptotic cells in vehicle-, anti-VEGF-, and lenvatinib-treated NPC tumors. Scale bar = 50 mum. Quantification of Ki67 + , cleaved caspase-3 + signals, and PA index in vehicle-, anti-VEGF-, and lenvatinib-treated NPC tumors. ( n = 8 random fields per group) G Representative micrographs of CD31 + microvessels and CA9 + hypoxic areas in vehicle-, anti-VEGF-, and lenvatinib-treated NPC tumors. Scale bar in upper panel = 100 mum, scale bar in lower panel = 50 mum. Quantification of CD31 + tumor vessel parameters and CA9 + signals in vehicle-, anti-VEGF-, and lenvatinib-treated NPC tumors ( n = 8 random fields per group). H Quantification of hCD45 + hCD14 + population, hCD45 + hCD19 + population, hCD45 + hCD3 + population, and hCD45 + hCD56 + population in the NPC TME ( n = 3 samples per group). I Quantification of mCD45 + mCD11b + mF4/80 + population, mCD45 + mB220 + population, mCD45 + mC</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_20588_jciinsight-7-150323-g047.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Figure 6 MALP ablation blocks bone marrow recovery after radiation. ( A ) Representative fluorescence images of Td + cells, Perilipin + LiLAs, and CD45 + hematopoietic cells in femoral bone marrow of Adipoq/Td/DTR mice after receiving 2 weeks of vehicle (Veh) or DT injections with or without prior radiation. Scale bar: 20 mum (top), 100 mum (middle), and 20 mum (bottom). ( B ) Quantification of CD45 + cells per bone marrow area. n = 3-6 mice/group. ( C ) Bone marrow cells were flushed from femurs and counted. n = 3-8 mice/group. ( D ) Cell counts of hematopoietic lineage cells in the bone marrow. n = 3-11 mice/group. B cells = B220 + , T cells = CD3 + , myeloid cells = Gr1 + and/or Mac1 + . ( E ) Cell counts of HSPCs. n = 3-11 mice/group. LK, Lineage - cKit + , LSK, Lineage - Sca1 + cKit + , SLAM LSK, Lineage - Sca1 + cKit + CD48 - CD150 + , MPP, Lineage - Sca1 + cKit + CD48 + CD150 - . ( F ) Representative fluorescence images of Adipoq/Td/DTR femoral bone marrow with Emcn staining (vessels). Arrows point to Td + pericytes. Scale bar: 20 mum. ( G ) Quantification of bone marrow vessel diameter, density, and area. ( H ) The number of pericytes per vessel length (VL) was measured. n = 3-4 mice/group. ( I ) The percentage of Emcn + endothelial cells in bone marrow was measured by flow cytometry. n = 3-4 mice/group. ( J ) qRT-PCR analysis of hematopoietic and angiogenic factors in sorted Td - and Td + cells from bone marrow before and after radiation. n = 4 mice/group. Statistica</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15202_gr2.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Fig. 2 Generating immuno-CRISPR (iCR) mice and evaluating the CRISPR-mediated modifications by sequencing. ( A ) Model describing the experimental setup where CD45.1 + Lin- BM cells were modified by CRISPR targeting Zap70 and grafted into irradiated CD45.2 + recipients. ( B ) Flow cytometry analysis of cells in the blood of Zap70 iCR mice and WT control mice eight weeks post transplantation. Cells gated on viable, CD45.1+, single lymphocytes. ( C ) Quantification of B and T cells in the blood of WT and Zap70 iCR mice in (B). ( D ) Analysis of the level of mutations in the sgRNA targeted Zap70 region in the BM cells used for transplantation, total cells from the blood, as well as in B and T cells sorted from the spleen of Zap70 iCR mice and WT control mice 8 weeks after engraftment. ( E ) Model describing the experimental setup where a secondary transplantation was used to amplify the population of successfully modified mice. ( F ) Analysis of the level of mutations in the sgRNA targeted GFP region in blood cells of the GFP iCR mice four weeks after transplantation, in an experiment with low efficiency. One mouse showed good knockout efficiency (labeled in orange) and was used as BM donor for secondary transplantation. ( G ) Kinetics of the level of mutations of GFP in the secondary iCR mice. ( H ) As examples, representative flow cytometry plots and ( I ) GFP + cell population percentage of alveolar macrophages, B1 cells, neutrophils and germinal center B cells from secondary</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19146_elife-70554-fig8.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Figure 8. Increased IL-2 production impairs T follicular helper (Tfh) cell formation and the germinal centre response. Assessment of the Tfh cell and germinal centre response in Il2 cre/+ ; Rosa26 stop-flox-Il2/+ transgenic mice that do not switch off IL-2 production, and Il2 cre/+ ; Rosa26 +/+ control mice 12 days after influenza A infection. Flow cytometric contour plots ( A ) and quantification of the percentage of CXCR5 high PD-1 high Foxp3 - CD4 + Tfh cells in the mediastinal lymph node ( B ) and spleen ( C ). Flow cytometric contour plots ( D ) and quantification of the percentage of Bcl6 + Ki67 + B220 + germinal centre B cells in the mediastinal lymph node ( E ) and spleen ( F ). The height of the bars indicates the median, each symbol represents one mouse, data are pooled from two independent experiments. p-Values calculated between genotype groups by Mann-Whitney U test.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19147_nihms-1750833-f0002.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Fig. 2. Effect of different PVA hydrolysis rates and molecular weights on ex vivo cultured human cord blood CD34 + hematopoietic stem and progenitor cells. a , Human cord blood CD34 + cells were cultured in PVA media and cell numbers were counted at day 14. Three independent experiments were performed with cord blood CD34 + cells derived from different donors. Cell cultures were started from 7 x 10 3 (Exp.1) or 5 x 10 3 (Exp. 2 and 3) CD34 + cells. Mean +- S.D is shown. Statistical significance was calculated using ANOVA followed by Tukey-Kramer; *p < 0.05, **p < 0.01. b , Proliferation of the two different CD34 + cell fractions after 7-day culture in PVA-containing media. Fifty cells were sorted into four wells in a 96-well plate and cell numbers in each well were counted at 7-day. Statistical significance was calculated using ANOVA and Tukey-Kramer. **p < 0.01.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14887_gr6.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Figure 6 Assessments of organ damage and mouse metabolites during HLSA or recovery from HLSA. A , upper left panel , MMP-1, IL-1beta, and CRP levels in plasma had no significant change between the control group, HLSA group, and R-HLSA group. Upper right panel , CK-MB as a marker of heart injury in the plasma had no significant change between the control group, HLSA group, and R-HLSA group. Lower left panel , creatinine and BUN as markers of kidney injury in the plasma slightly increased in the HLSA group and returned to normal level after recovery from HLSA. Lower right panel , AST and ALT as markers of liver injury in the plasma showed no change between the control group, HLSA group, and R-HLSA group. Data were presented as mean +- SD (N = 6; ANOVA: ** p < 0.01). B , upper panel , food consumption and water consumption 3 days before and 3 days after a single ATP-induced HLSA depicted no change. Data were presented as mean +- SD (N = 6; ANOVA: p > 0.05). Lower panel , metabolomics analysis of scores plot from PCA analysis based on 1 H NMR data from the plasma, brain, liver, and kidney of the control group, HLSA group, and R-HLSA group. The PCA score showcased clusters correspond to metabolic patterns in different groups, with each point representing one sample. Circles represent 95% confidence interval for each score in each group (see also Figs. S5-S8 ). C , draining lymph nodes of mice that underwent HLSA once a day for 10 consecutive days were analyzed with FACS. CD44 and</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14912_jciinsight-6-143245-g005.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Figure 5 CD4 surface expression of CD45RB and global glycosylation are altered in SLE123 mice. ( A and B ) Cell surface expression of CD45RB and total CD45 were measured by flow cytometry on CD4 + T cells. SLE123 demonstrated a downregulation of CD45RB on the cell surface as compared with B6 CD4 + T cells. There was no difference in pan-CD45 expression. Quantified in B . ( C ) CD45 is composed of an intracellular region that controls cytoskeletal binding and its phosphatase activity. The extracellular domain is composed of a region with fibronectin repeats that is heavily N-glycosylated. An alternatively spliced region is heavily O-glycosylated, and this region imparts unique functions to each CD45 isoform. Additionally, a sialic acid residue on the B portion of this region is essential for the binding of therapeutic aCD45RB. ( D and E ) We utilized lectins to detect the level of alpha-2,3-linked sialylation (MALII), O-linked glycosylation (Jacalin), and N-linked glycosylation (PHA-L) in CD4 + T cells from B6 and SLE123 mice. We determined SLE123 CD4 + T cells had reduced levels of alpha-2,3-linked sialic acids and O-glycosylation and an increase in N-glycosylation. Quantified in E . ( F ) Utilizing an antibody that detects a desialylated form of anti-CD45RB, we determined SLE123 CD4 + T cells possessed increased binding of this antibody compared with B6. ( G and H ) To determine the binding of therapeutic aCD45RB to B6 and SLE123 CD4 + T cells, we incubated splenocytes from</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_15196_41467_2021_22173_Fig7_HTML.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Fig. 7 Upregulation of PD-L1 by MTHFD2 is required for tumorigenesis. a - b A total of 2 x 10 6 ( a ) or 5 x 10 6 ( b ) Pan02 cells stably infected with lentivirus carrying indicated shRNAs or exogenous expressed PD-L1, were subcutaneously injected into athymic nude mice ( a ) or C57 mice ( b ), tumor volume was calculated every 7 days. Tumor xenografts at the 28th day in nude mice ( a ) or the 21th day in C57 mice ( b ) were shown. Data represent the means +- s.e.m ( n = 8 mice per group); p value (Student's t test, two-sided) with control is presented. c , PD-L1 mRNA levels in tumor tissues in C57 mice were analyzed by real-time PCR. The values are presented as mean +- s.e.m ( n = 3); p values (Student's t test, two-sided) with control or the indicated groups are presented. d The lysates of 8 pooled tumor tissues in C57 mice were subjected to immunoblotting analyses using the indicated antibodies. e Immunohistochemical staining was performed on tumor sections in C57 mice with anti-CD8 antibody. Representative images are shown. Scale bars, 50 mum. Histological semi-quantification was performed. f Cells digested from indicate tumor tissues in C57 mice were stained with anti-CD45 antibody and subjected to flow cytometric analyses (also see Supplementary Fig. 7b ). Representative images (1 out of 3 experiments) are shown. g A schematic model showing the role of MTHFD2 in tumor immune evasion. MTHFD2 promotes PD-L1 mediated tumor immune evasion through the folate-cycle-UTP-UDP-G</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_9908_fimmu-11-590266-g001.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Figure 1 Development of myeloid cell populations is not detectably altered in MphCK2alpha -/- mice. (A) Schematic of Csnk2a targeting vector. (B) Immunoblots of lysates from BMDMs, splenocytes, or peritoneal cavity cells of LysM cre or LysM cre CK2alpha fl/fl (MphCK2alpha - / - ) mice were probed for CK2alpha or beta-actin as a loading control. n = 2. (C) Splenic myeloid cell populations were stained and analyzed by flow cytometry. Plots depict gating for representative F4/80+ macrophages, Ly6C+ monocytes, and neutrophils (also Ly6G+). (D) Cells from spleen were stained for flow cytometry to enumerate immune cell populations. Data are from pooled experiments, n = 4-12 mice/group. (E) Cells from bone marrow were stained for flow cytometry to evaluate bone marrow precursor populations including common myeloid progenitors (CMPs), granulocyte-monocyte progenitors (GMPs), and megakaryocyte-erythrocyte progenitor (MEP). Cells were pre-gated on Lin-(B220, CD3, CD11b, GR-1 and TER-119), Sca-1-, cKit-. Density plots are representative from two experiments.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_8372_fimmu-11-576310-g0004.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Figure 4 Ptpn6 deletion drives robust anti-tumor immunity in two immune-rich syngeneic tumor lines. (A) Flow cytometric analysis of live CD45 + cells from B16F10 melanoma tumors isolated from tamoxifen-treated Ptpn6 fl/fl and Ptpn6 fl/fl ERT2-cre mice at day 14 post tumor implantation. (B) B16F10 tumor volume measurements in tamoxifen-treated Ptpn6 fl/fl ERT2-cre and Ptpn6 fl/fl mice. Each data point represents the average tumor volume of all mice in a given group. Data is representative of three independent experiments with 5-7 mice/group. (C) Shp1 protein relative to total Erk2 protein in peripheral blood cells from indicated mice 14 days after initial tamoxifen dose (200 mg/kg bid for 4 days) and 7 days after B16F10 tumor cells were implanted. Data is representative of at least three independent experiments with 5-7 mice per group. (D) Flow cytometric analysis of live CD45 + cells from E0771 tumors isolated from tamoxifen-treated Ptpn6 fl/fl and Ptpn6 fl/fl ERT2-cre mice at day 19 post tumor implantation. (E) E0771 tumor volume measurements in tamoxifen-treated Ptpn6 fl/fl ERT2-cre and Ptpn6 fl/fl mice. Each data point represents the average tumor volume of all mice in a given group. Data is representative of three independent experiments with 4-5 mice per group. Statistical significance was calculated at each time point using an unpaired t -test. (F) Shp1 protein relative to total Erk2 protein in peripheral blood cells from indicated mice 14 days after initial tamoxifen d</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12509_41467_2020_18491_Fig7_HTML.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Fig. 7 Lgr4/Gpr48 is involved in CML stem cell self-renewal in vivo. a RNA-Seq determinations of mRNA levels of the indicated GPCR family genes in LT-CML stem cells isolated from Gdpd3 +/+ tet-CML-affected mice (22 males, 12 females) and Gdpd3 -/- tet-CML-affected mice (five males, five females). Results are expressed as FPKM (see Methods). Data are the mean FPKM +- s.d. ( n = 3 biologically independent samples) ( P -value, unpaired two-sided Student''s t -test). Results of the MA-plot and GO term enrichment analyses for these RNA-Seq data are shown in Supplementary Fig. 11a, b . b Quantitation of the colony-forming capacity of Gdpd3 +/+ CML-LSK cells that were transduced with/without Cy3-labelled siRNA targetting mouse Lgr4/Gpr48 mRNA (mLgr4 #3 or Lgr4 #4). Cy3 + and Cy3 - CML-LSK cells were purified at 3 days post-transduction and plated in a semi-solid methylcellulose medium. Data are the mean colony number +- s.d. ( n = 3) and are representative of three biologically independent experiments. ( P -value compared with control, unpaired two-sided Student''s t -test). The relevant FACS data are shown in Supplementary Fig. 12 . c Absolute numbers of LT-CML stem cells isolated from BM of the two hind limbs of Lgr4 +/+ tet-CML-affected mice (four males, one female) and Lgr4 Gt/Gt tet-CML-affected mice (five females) ( n = 5 biologically independent samples). Data are the mean absolute numbers +- s.d. of LT-CML stem cells ( P -value, unpaired two-sided Student''s t -test). (See S</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12509_41467_2020_18491_Fig1_HTML.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Fig. 1 Gdpd3 is implicated in CML disease initiation in vivo. a Diagram of pathways of lysophospholipid biosynthesis. G3P is converted into LPAs, and LPAs are then converted into phospholipids by the addition of polar bases via the Kennedy (de novo) pathway. The Lands'' cycle (remodelling pathway) generates lysophospholipids of distinct composition by substituting fatty acid ester and polar base groups of phospholipids. Lysophospholipase D Gdpd3 converts lysophospholipids back into LPAs by catalysing hydrolysis (magenta dotted line). (PC Phosphatidylcholine, PS Phosphatidylserine, PE Phosphatidylethanolamine, PI Phosphatidylinositol, LPC Lysophosphatidylcholine, LPS Lysophosphatidylserine, LPE Lysophosphatidylethanolamine, LPI Lysophosphatidylinositol). b qRT-PCR determination of Gdpd3 mRNA expression in LT-stem (LT), CD48, MPP, and LK cells (see Supplementary Fig.2) isolated from Gdpd3 +/+ tet-CML-affected (SCL-tTA + TRE-BCR-ABL1 + ) mice (one male, six females) or normal littermate (SCL-tTA + ) mice (four males, four females). Data are the mean ratio +- s.d. of transcript levels normalised to Actb ( n = 3 biologically independent samples) ( P -value, unpaired two-sided Student''s t -test). c Quantitation of the colony-forming capacity of Gdpd3 +/+ CML-LSK cells that were transduced with/without Cy3-labelled siRNA targetting mouse Gdpd3 mRNA (mGdpd3 siRNA #1 or #3). Cy3 + and Cy3 - CML-LSK cells were purified at 3 days post-transduction and plated in semi-solid methylcellulo</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_5903_fimmu-10-01980-g0002.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Figure 2 Tpl2 didn't affect peripheral immune activation during FH pathogenesis. The splenic cells or peripheral blood immune cells were isolated from P. acnes -primed WT and Tpl2 -KO mice at day 3, 5, and 7 as described in Materials and methods ( n = 4 mice/group), and subjected for flow cytometry analysis. (A-F) Flow cytometry analysis of the frequencies and absolute numbers of CD4 + T cells, CD8 + T cells, B220 + B cells, CD11c + dendritic cells (A,B) , CD4 + Foxp3 + Treg cells (C,D) , and IFN-gamma- and TNF-alpha-producing pathogenic Th1 cells (E,F) in the spleens of WT and Tpl2 -KO mice at day 7 after P. acnes priming. Data are presented as representative plots of the frequencies of immune cell subpopulations (A,C,E) and a summary graph of the cell frequencies or absolute cell numbers (B,D,F) . (G-J) Flow cytometry analysis of the frequencies and absolute numbers of CD4 + T cells in the spleens (G,H) or peripheral blood (I,J) of WT and Tpl2 -KO mice at day 3, 5, and 7 after P. acnes priming. Data are presented as representative plots of the frequencies of immune cell subpopulations (G,I) and a summary graph of the cell frequencies or absolute cell numbers (H,J) . Results are mean +- SD from three independent experiments.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_5903_fimmu-10-01980-g0003.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Figure 3 Tpl2 reduced liver infiltration of pathogenic CD4 + T cells. Liver-infiltrating immune cells were isolated from P. acnes -primed WT and Tpl2 -KO mice at day 3, 5, and 7 as described in Materials and methods ( n = 4 mice/group). (A-G) Flow cytometry analysis of the frequencies and absolute numbers of CD4 + and CD8 + T cells, B220 + B cell, CD11c + dendritic cells (A-C) , CD4 + Foxp3 + Treg cells (D,E) , and IFN-gamma- and TNF-alpha-producing pathogenic Th1 cells (F,G) in the livers of WT and Tpl2 -KO mice at day 7 after P. acnes priming. Data are presented as representative plots of the frequencies of immune cell subpopulations (A,D,F) and a summary graph of the frequencies and absolute cell numbers (B,C,E,G) . (H,I) Flow cytometry analysis of the frequencies and absolute numbers of CD4 + T cells in the livers of WT and Tpl2 -KO mice at day 3, 5, and 7 after P. acnes priming. Data are presented as representative plots of the frequencies of immune cell subpopulations (H) and a summary graph of the absolute cell numbers (I) . Results are mean +- SD from three independent experiments. Two-tailed Student's t -tests were performed. * P < 0.05; ** P < 0.01.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_7721_41467_2019_9884_Fig6_HTML.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Fig. 6 TLR2 + macrophages, pDCs, and PB in the small intestine bind PSA and induce IL-10 secretion. Gating strategy for mononuclear cells isolated from a duodenum (Duod) and b ileum (Ile) of WT and Rag mice analyzed for binding of fluorescent A488-conjugated PSA (left two plots). CD45 - intra-epithelial cells (CD45 - IEC: middle histogram) and CD45 + gated intra-epithelial leukocytes (CD45 + IEL: second right histogram) isolated from the a Duod and b Ile of WT (red) and Rag (blue) mice were analyzed for reactivity to PSA-A488. CD45 + CD11c - B220 + B cells, PDCA1 + B220 + CD11c + pDCs and CD138 + B220 + PB and B220 low PC isolated from a Duod and b Ile of WT mice were analyzed for PSA reactivity (right histogram). Flow cytometry plots show CD11c + PDCA1 - cDC, PDCA1 + B220 + pDC, and B220 + CD19 + B cells isolated from spleen, MLN, PP, IEL, or LP of WT mice were stimulated with c PSA or d LTA-SA (TLR2 agonist) and analyzed for IL-10 expression. e Plots summarize data from c and d and show % IL-10 + B cells (left), cDCs (middle), and pDCs (right) from spleen, MLN, PP, IEL, and LP stimulated with PSA or TLR2 (LTA-SA) ( n = 3 mice). All data show mean +- SEM</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12887_nihms-1545821-f0008.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Figure 7. NOX2 and FOXC1 Are Important for the Growth of Primary Human Myeloid Leukemia Cells (A) The Cancer Genome Atlas (TCGA) database for AML was used to analyze the expression levels of several NADPH-dependent oxidases (NOX1-NOX5), accessory subunits (NCF1, NCF2, NCF4, NOXA1, NOXO1, p22Phox, RAC1, and RAC2) as well as related oxido-reductase enzymes (dual-oxidases 1,2, A2). The reads per kilobase of transcript per million mapped reads (RPKM) values for each gene in a total of 188 AMLs are shown. (B) RNA-seq analysis was performed on functionally validated leukemic stem cells isolated from human primary AMLs. The RPKM value for each gene is shown. Unpublished data are used with permission. Additional supporting data are shown in Figure S7A . (C) Equal numbers of control or shNOX2-transduced primary AML cells were cultured in vitro in the presence of 10 ng/mL of IL-3, SCF, and FL3, and the relative percent expansion is reported for each specimen. n = 3, mean +- SD. *p < 0.05; **p < 0.01. (D) Control and shNOX2 primary AML cells were purified and cultured in vitro for 12 days. Annexin V, DAPI staining was performed to evaluate the degree of apoptotic cell death. A representative flow plot (left) and quantitation of 3 technical triplicates (right) are shown. Additional data are shown in Figure S7B . (E) The relative expression level of NOX2 , CEBP epsilon, Elane , and CTSG is shown in AML specimens in which NOX2 was knocked down using shRNAs. Additional supporting data are p</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_7916_fimmu-09-03114-g0002.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Figure 2 Analysis of the B lymphocyte populations expanded in TRAF3/BCL2 double-tg mice with lymphoid dyscrasias. Three-color flow-cytometry analysis was performed to determine the phenotype of expanded B lymphocyte populations. Gating of the expanded population was based on the CD45R/B220 and FSC plot of each sample analyzed and is indicated in the figure. The surface molecules analyzed are indicated in the plots, as well as the percentage of cells found in each quadrant. The quadrants settings were selected based on the staining of isotype-controls (not shown). The tissue source where the analyzed lymphocytes were extracted from and the type of B cell malignancy developed by the TRAF3/BCL2 double-tg mice, according to the flow-cytometry and immunohistochemical analysis, is indicated in the figure.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_4977_fimmu-09-02522-g0007.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Figure 7 ATF3 promotes IL-22-induced STAT3 phosphorylation by suppressing phosphatases. (A) Freshly isolated ileum crypts, or (B) ileum organoids at day 6 of culture, were stimulated with IL-22, followed by fixation and intracellular staining of phospho-STAT3, and analyzed by flow cytometry. Western blot analysis of (C) IL-22-stimulated CMT93 cells, or (D) IL-22-stimuated colon fragments isolated from the indicated mice, for the expression of the indicated proteins. (E) Quantitative real-time PCR analysis of IL-22R1 and IL-10R2 mRNA levels in freshly isolated ileum crypts from mice. (F) Flow cytometry analysis of IL-22R1 in freshly isolated ileum crypt cells gated on the CD45 - EpCAM + population. (G,H) Western blot analysis of unstimulated or IL-22-stimulated CMT93 cells for the indicated proteins. ATF3 -/- CMT93 cells with SHP2 knockdown (ATF3 -/- SHP2 KD ) were indicated. Images were representative of four independent experiments (G-H) . Results were from two independent experiments (A-F) . ""n"" refers to the number of mice analyzed (A,B,E,F) . Statistical analysis was done by multiple comparison in Two-way ANOVA test using Prism software. * P < 0.05, ** P < 0.005, *** P < 0.0005.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_4977_fimmu-09-02522-g0001.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Figure 1 ATF3 maintains intestinal homeostasis. (A) Comparison of colon length between naive mice as indicated. (B) Colon crypts from mice were isolated by shaking colon fragments in EDTA and counted under light microscopy. (C) Flow cytometry analysis of Ki67 and CD24 expression in ileum crypts, gated on the CD45 - EpCAM + populations, from the indicated naive mice. (D) Representative micrographs showing intestinal organoids derived from naive mice. (E) Quantitative real-time PCR analysis of cell cycle genes in naive ileum organoids at day 6 of culture (""n"" indicates organoids derived from 4 mice each group). (F) Representative confocal images of whole mount tissues with co-immunofluorescence staining of UEA-1 and WGA in naive ileum villi. Results were from at least two independent experiments and ""n"" refers to the number of mice unless indicated otherwise. All mice were at the age of 2~3 months old when analyzed. Statistical analysis was done using Multiple T -test on Prism software. * P < 0.05, ** P < 0.005, *** P < 0.0005.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_4528_41467_2018_4831_Fig1_HTML.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Fig. 1 Loss of miR-143/145 results in reduced LT-HSC frequency. a Frequency of long-term-HSC (LT-HSC, CD45 + EPCR + CD48 - CD150 + ), LSK/short-term HSC (Lin - Sca1 + c-Kit + ), common myeloid progenitors (CMP, Lin - Sca1 - c-Kit + CD34 + CD16/32 lo ), granulocyte-macrophage progenitors (GMP, Lin - Sca1 - c-Kit + CD34 + CD16/32 hi ), and megakaryocyte-erythrocyte progenitors (MEPs, Lin - Sca1 - c-Kit + CD34 - CD16/32 lo ) in the marrow of 8-12-week- old wild-type (WT), miR-143/145 +/- , and miR-143/145 -/- mice, as analyzed by flow cytometry (median +- 1.5 IQR, WT n = 11, 143/145 +/- n = 9, 143/145 -/- n = 8). b Marrow cellularity (2 femurs and 2 tibias) (WT n = 3, 143/145 +/- n = 4, 143/145 -/- n = 8). c Colony-forming unit (CFU) assay of marrow cells from WT and miR-143/145 -/- mice (mean +- SEM, WT n = 11, 143/145 -/- n = 10). d Primary CFU cells were replated in equal proportions per condition, normalized to the number of input cells, to generate secondary CFUs (mean +- SEM, WT n = 9, 143/145 -/- n = 7). e Estimate of HSC frequency in WT and miR-143/145 -/- mice by limiting dilution assay. Shown is a log-fraction plot of the limiting dilution model. The slope of the line is the log-active cell fraction. The dotted lines give the 95% CI</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14845_nihms-1001095-f0003.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_4672_nihms950683f4.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Figure 4 Surgical denervation of young bone marrow induces premature HSC and niche aging (a) Schematic illustration of surgical denervation experiment. The sciatic and femoral nerves were transected in young (2 months old) C57BL/6 mice and the mice were analyzed 4 months post surgery, at 6 months of age. (b) Absolute numbers of HSCs (lineage - Sca-1 + c-Kit + CD48 - CD150 + ) isolated from Sham and Denervated (Den) femurs (n=7 mice). (c, d) Total peripheral blood (CD45.2 + ), blood myeloid (Mac-1 + CD45.2 + ) and blood B cell (B220 + CD45.2 + ) donor chimerism at the indicated time points post transplantation (c) and bone marrow donor chimerism (Total CD45.2 + (BM); Myeloid (My), Mac-1 + CD45.2 + ; B cell (B), B220 + CD45.2 +; and T cell (T), CD4 + /CD8 + CD45.2 + ) 5 months after primary transplantation of 200 HSCs derived from either sham or denervated (Den) femurs and transplanted in competition with young BM competitor cells (n=4 sham, 6 denervated mice) (left) and 5 months after secondary transplantation of 3 x 10 6 bone marrow from primary recipients (right) (d). (e) Left, representative confocal z -stack projections of HSCs sorted from sham or denervated femurs and stained with Cdc42, Tubulin and DAPI. Scale bar, 10 mum. Right, quantification of the percentage of Cdc42 and Tubulin polarized HSCs out of total HSCs scored (total of 356 sham and 353 denervated HSCs isolated from 4 mice per group). (f) Left, representative confocal z -stack pro</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_4316_fimmu-09-00592-g002.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_4095_etm-15-02-1847-g00.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Figure 1. VEGF and bFGF promote the differentiation of MSCs into EC-like cells. (A) Expression of MSC surface markers was confirmed using flow cytometry. (B) Morphological features of isolated MSCs and MSC-derived EC-like cells following induction as observed under an inverted microscope. The red and white arrows indicate spindle-shaped and polygon-shaped cells, respectively. Magnification, x20. (C) Factor VIII expression was detected in MSC-derived EC-like cells via immunohistochemistry and light microscopy with brown staining indicating the positive signal. VEGF, vascular endothelial growth factor; bFGF, basic fibroblast growth factor; MSCs, mesenchymal stem cells; EC, endothelial cell; Ctrl, control; CD, cluster of differentiation.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_6017_zjv0061833750003.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/jbmr3352-fig-0005-1-20190103084817.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/jbmr3352-fig-0002-1-20190103084817.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_5557_41467_2017_1022_Fig7_HTML.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_5557_41467_2017_1022_Fig5_HTML.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_5557_41467_2017_1022_Fig2_HTML.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_5557_41467_2017_1022_Fig1_HTML.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_3817_41467_2017_1029_Fig1_HTML.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Fig. 1 In vivo depletion of Cdkn1a rescues GC formation in Ezh2 -/- mice. Ezh2 fl/fl , Cdkn1a -/- , Ezh2 fl/fl ;Cgamma1-cre and Ezh2 fl/fl ;Cgamma1-cre; Cdkn1a -/- littermate mice were immunized with SRBC to induce germinal center (GC) formation and were killed 10 days later. a Flow cytometry plot of one representative mouse spleen per group. The gated area shows the percentage of GC B cells (GL7 + FAS + ) within live B cells (B220 + DAPI-, see Supplementary Fig. 2A for gating strategy). b Average of GC B populations of each group of mice quantified by flow cytometry as in a ( n = 7 mice per group). c Formalin fixed paraffin embedded splenic tissue was stained for PNA, Ki67, EZH2, and B220. One representative picture of three spleens analyzed per group is shown. d - f Quantification of PNA staining from c ( n = 3 spleens per group). d ""#GC/spleen section"" is the count of all GC per spleen section. e ""GC area/total spleen area"" is the quantified area of each individual GC divided by the total area of the spleen section. f ""Total GC area/total spleen area"" is the sum of all GC quantified areas in a certain section divided by the total area of that spleen section. g Splenocytes were permeabilized and stained for GC B and EZH2 using a fluorochrome-conjugated anti EZH2 antibody. The gated area shows the percentage of GC B cells (GL7 + FAS + ) within live B cells (B220 + DAPI-, see Supplementary Fig. 2A for gating strategy) that are EZH2 positive. The flow plot shown is repre</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_3817_41467_2017_1029_Fig3_HTML.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Fig. 3 Characterization of a 3D B cell follicular organoid to model the GC reaction. a Scheme of 3D B cell follicular organoid fabrication. Splenic B cells are co-encapsulated with 40LB stromal cells and IL4 into an RGD-presenting nanocomposite hydrogel that contain gelatin ionically cross-linked with synthetic silicate nanoparticles. b Representative fluorescence pictures of splenic GFP B cells in 3D organoid culture. c Flow cytometry plot of a 3D B cell follicular organoid. The gated area on the top shows the live B cells (B220 + DAPI-) and on the bottom plot, the organoid GC B cells (GL7 + FAS + ) within live B cells. d Average of GC B populations of organoids quantified as in c . e Average of percentage of proliferating organoid GC B populations, quantified as indicated in Supplementary Fig. 4B . f MFI of proliferation dye from e . g Flow cytometry plot of GC B cells stained with annexinV. h Average of percentage of apoptotic GC B cells quantified as in g . i RNA-seq profiles of organoid GC B cells after 4 and 6 days in culture (organoid GCB d4, n = 4 spleens, and d6, n = 3 spleens) were projected into the principal component space defined by GC B cells sorted from immunized mice (in vivo GCB, n = 6 mice), CD138 + plasma cells (in vivo PC, n = 6 mice) and FAS-GL7-IgD + B220 + naive B cells (NB, n = 3 mice). j , k Heat maps of gene expression level of GC B cells showed in i , represented as log2 ratio relative to mean naive B cells j and to mean plasma cells k . PC1/2 = pr</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_3817_41467_2017_1029_Fig4_HTML.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Fig. 4 CDKN1A repression by EZH2 is required for GC B cell cycle progression. a - f Organoids were generated using B cells isolated from Ezh2 fl/fl ;Cgamma1-cre, Cdkn1a -/- , Ezh2 fl/fl ;Cgamma1-cre; Cdkn1a -/- and Ezh2 fl/fl control mice ( n = 3 mice per group) and were harvested for flow cytometry analysis after 4 days in culture. a Flow cytometry plots of representative organoids from each genotype. The gated area shows the percentage of organoid GC B cells (GL7 + FAS + ) within live B cells (B220 + DAPI-). b Average of percentage of organoid GC B populations quantified by flow cytometry as in a ( n = 3 biological replicates per group). c Organoids received a BrdU pulse of 2 h before harvest. Cell cycle was analyzed by BrdU staining and 7AAD to measure DNA content. The representative gated area shows the percentage of organoid GC B cells (GL7 + FAS + B220 + DAPI-) that are in S phase (BrdU + ). d Average of percentage of organoid GC B populations in S phase of each group of genotype quantified by flow cytometry as in c ( n = 3 biological replicates per group). e Organoid cells were permeabilized and stained for EZH2 and GC markers GL7, FAS, and B220 to identify organoid GC B cells. The flow cytometry plot shows one representative sample per genotype group. f MFI of EZH2 in organoid GC B cells ( n = 3) quantified by flow cytometry as in e . g - m Organoids were generated using B cells isolated from 3 Cdkn1a +/+ and 3 Cdkn1a -/- mice. g Scheme of EZH2 inhibitor GSK343 and Br</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_3786_jciinsight-2-91914-g009.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_5933_koni-06-03-1287247-g004.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_3431_pone0171796g006.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Fig 6 Tn P acts systemically during the induction phase modulating DCs and induces regulatory cells. Splenocytes from EAE mice treated with vehicle or Tn P (n = 5/group) were isolated at day 7, and analyzed. A ) The MFI of MHC class II, CD40, CD80, CD86 in cDC (CD11c+CD11b+) and B ) MFI of PDL-1 and PDL-2 in pDC (CD11c+B220 low ) were analyzed by flow cytometry (50,000 events). C ) The percentage of CD4+ cells, D ) and the MFI of CD18, CD40L, and CD69 in the CD4+ gate were analyzed by flow cytometry. E , F , G ) The percentages of FOXP3-positive CD4+CD25+ Treg, IL-4-positive CD4 Th2 cells and CD5-positive CD19+CD1d+ Breg cells were analyzed by flow cytometry. Values in the bar graphs are the mean +- SEM. * p < 0.05 and ** p < 0.01 compared with vehicle-treated EAE-mice.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_8502_JEM_20160247_Fig5.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Figure 5. K14Cre;fl/fl mice exhibit prominent autoimmunity with Th2/Th17 cell polarization and abnormal B cell activation leading to autoantibody production. (A) A representative image of the gross appearance of spleens and inguinal lymph nodes from 3-mo-old fl/fl and K14Cre;fl/fl mice. (B) The number of splenocytes in 3-mo-old fl/fl and K14Cre;fl/fl mice was counted. n = 4 per each group. (C) Lymphocytes isolated from inguinal lymph nodes were stained for CD3 and CD4 and intracellularly stained for IL-4, IL-17A, and IFN-gamma. (Top) Representative two-dimensional plots for IL-4 and IL-17A in CD3 + CD4 + cells. (Bottom) The percentages of cells positive for IL-4, IL-17A, and IFN-gamma are summarized. n = 7 mice per each group. (D) Splenocytes from 3-mo-old fl/fl and K14Cre;fl/fl mice were stained for B220 and CD19. B220 + CD19 + cells were analyzed for CD19 expression. A representative histogram of mean fluorescence intensity (MFI; top) and the comparison of mean fluorescence intensities (bottom) are shown. n = 4 mice per genotype. (E) Sera from 3- and 8-mo-old mice were analyzed for the concentrations of total IgG, IgM, and IgA. n = 5-7 mice per genotype. Note that the results are shown with log scale. (F) Sera from 1-, 2-, 3-, and 8-mo-old mice were analyzed for the concentration of IL-6. n = 6-7 mice per genotype. (G) B cells were isolated from splenocytes of 3-mo-old mice and cultured for 48 h, either unstimulated or stimulated with anti-CD40 antibody (alphaCD40Ab). The c</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12866_nihms845084f5.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Figure 5 NG2-cre, but not NG2-cre ERTM , targeted cells are the source of Scf in the bone marrow (a) Whole-mount sternum from NG2-cre/ iTdTomato/ Scf-GFP mice, anti-VE-cadherin. Representative images from 3 mice. Scale bars, 20 mum. (b) Representative FACS plot showing percentage of NG2-cre/ iTdTomato + cells within CD45 - TER119 - CD31 - Scf-GFP + cells. n=3 mice. (c-e) Analyses of LepR-cre/ Scf fl/- mice. (c) Numbers of HSCs (left) in BM and LSK cells in spleen (right). n=4 mice for cre (-), n=3 mice for cre (+). (d) FACS analyses of HSC (CD150 + CD48 - LSK) cell cycle with Ki-67 and Hoechst 33342 staining. n=5 mice for cre (-), n=6 mice for cre (+). (e) HSC localization relative to arterioles. Error bars: n=3 mice. P value has been calculated using n=272 HSCs for cre (-), 293 HSCs for cre (+) pooled from 3 mice per group. P =0.3402. (f-i) Analyses of NG2-cre/ Scf fl/- mice. (f) Numbers of total BM cells (left) and CD150 + CD48 - LSK HSCs (right) in BM. n=5 mice for cre (-), n=7 mice for cre (+). (g) Percentages of donor-derived cells after competitive reconstitution. n=5 mice for cre (-), n=7 mice for cre (+). (h) FACS analyses of HSC cell cycle with Ki-67 and Hoechst 33342 staining. n=6 mice for cre (-), n=7 mice for cre (+). (i) HSC localization relative to arterioles. Error bars: n=3 mice. P value has been calculated using n=224 HSCs for cre (-), 274 HSCs for cre (+) pooled from 3 mice per group. P =0.2872. (j-l) Analyses of NG2-cre ERTM / Scf fl/- mice. (j) Absolute nu</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_3137_gr6.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Figure 6 Disease Modeling of herPAP Using miPAP iPSCs (A) Number of CD41 + progenitor-derived colonies in methylcellulose-based clonogenic assays employing complete (IL-6, erythropoietin, SCF, IL-3, and supplemented with 20 ng/ml human G-CSF + 20 ng/ml murine GM-CSF) or basic medium (50 ng/ml murine GM-CSF only; independent experiments, n = 3 miPAP1 and 2, n = 2 CD45.1 iPSC, mean +- SD) and representative pictures of colonies. Scale bars, 500 mum. (B) GM-CSF clearance assay comparing miPAP-Mphi with CD45.1(10.3) iPSC-Mphi, BMlin - -Mphi, and no cells incubated with 2 ng/ml GM-CSF: at indicated time points (0, 4, 10, 24, and 30 hr) GM-CSF concentrations in supernatants were analyzed by ELISA, normalized to 0 hr (independent experiments, n = 3 BMlin - and CD45.1 iPSC, n = 2 miPAP1 and 2, mean +- SD). (C and D) Flow cytometry plots of STAT5 phosphorylation levels upon stimulation with mGM-CSF (C) and (D) summary of mean fluorescence intensity (MFI) data (independent experiments, n = 3 BMlin - and CD45.1 iPSC, n = 2 miPAP1 and 2, mean +- SD). ns, not significant; ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001, two-way ANOVA.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_3129_nihms794951f5.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12858_ncomms9835-f2.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Figure 2 Loss of Gata5 from renal endothelial cells leads to renal alterations. ( a ) GATA5 is expressed in the kidney as assessed by western blot performed on total kidney extracts. ( b ) Gata5 is essentially expressed in the glomeruli as assessed by qPCR on isolated glomeruli (Glo) and microdissected tubules (Tub) from Wt mice kidneys. ( n =3-5 per group). The results are reported as mean+-s.e.m. * P <0.05 versus Gata5 +/+ mice (Mann-Whitney test). ( c , d ) Specific deletion of Gata5 in endothelial cells (e Gata5-null mice) virtually abolished renal and glomerular expression of Gata5 ( n =3 per group). The results are reported as mean+-s.e.m. * P <0.05 versus eGata5 +/+ mice (Mann-Whitney test). ( e ) The expression of the glomerular genes Nphs1 (nephrin) and Nphs2 (podocin) as measured by qPCR ( n =6 per group) was increased in Gata5 -null mice. The results are reported as mean+-s.e.m. * P <0.05 versus Gata5 +/+ mice; *** P <0.005 versus Gata5 +/+ mice ( t -test for nephrin; Mann-Whitney test for podocin). ( f - i ) Absence of Gata5 induces glomerular lesions (sections are stained with periodic acid Schiff; scale bar, 30 mum; n =5 per group) and renal inflammation as assessed by leucocytes CD45 immunostaining (scale bar, 200 mum; n =4 per group). The results are reported as mean+-s.e.m. *** P <0.005 versus Gata5 +/+ mice (Mann-Whitney test). ( j - n ) Deletion of Gata5 from endothelial cells reproduces the renal phenotype of global Gata5 deletion: both Nephs1 and Nphs2 tr</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12598_JCI83024f4.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_2622_ncomms8450-f7.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12693_2186-3326-76-293-g004AB.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Fig. 4 Analysis of B cell development in bone marrow and spleen. A. FACS analysis of BM B cells. BM cells from WT and RhoF KO mice (6-7 weeks old, n = 5, male: 40%) were stained with antibodies against CD43, B220, BP1, and CD24 and analyzed by flow cytometry. The number shows the percentage (mean +- standard deviation) of the indicated subpopulation within the parent population; Fraction A (germline pro-B cells), fraction B (DJ-rearranged pro-B cells), fraction C (Early pre-B cells), fraction D (Late pre-B cells), fraction E (newly formed B cells), and fraction F (follicular-type recirculating B cells). The figures are representatives of three independent experiments. B. FACS analysis of B cells from the spleen. Splenocytes from WT and RhoF KO mice (6-7 weeks old, n = 6, male: 33%) were stained with antibodies against CD23, CD21, and IgM and analyzed by flow cytometry. The number shows the percentage (mean +- standard deviation) of the indicated subpopulation within the parent population; T1 (Transitional 1), T2 (Transitional 2), Fo (mature follicular B cells), and MZ (MZ B cells). C. The number of B cell subsets in BM was calculated by multiplying the total number of viable (trypan blue negative) BM cells by the fraction of the target population in viable (7AAD negative) cells. The data are shown as mean +- standard deviation (6-7 weeks old, n = 5, male: 40%). White bars: WT. Black bars: RhoF KO. D. The number of B cell subsets in the spleen was also calculated by multiplyin</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_2678_cdd2014230f5.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_2678_cdd2014230f7.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_2678_cdd2014230f6.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12880_JI_1401608_f5.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12878_pone0091373s001.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_2211_nihms562570f1.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_2053_auto-9-1009-g2.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_1947_pgen1003226s005.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12671_nihms411554f3.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12671_nihms411554f2.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_1854_nihms-390477-f0005.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12579_pone0022043g004.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Figure 4 Lung leukocyte infiltration during influenza infection is comparable between PAD4 WT and KO mice. Experimental setup as described in Figure 2 . (A-C) Five mice per group were analyzed at d3 or d7 post infection. Leukocytes were isolated from infected lungs. (A) Total cell numbers of lung-infiltrating leukocytes at d3 and d7 p.i. Each symbol represents an individual mouse, filled squares represent PAD4 WT, open squares depict PAD4 KO mice. (B+C) The subsets of infiltrating leukocytes were enumerated by flow cytometry both at d3 p.i. (B) and d7 p.i. (C). Gated populations are indicated at the bottom of the graph. Total numbers of infiltrating cells are shown. WT mice are depicted in white bars, KO mice as grey bars. Bars represent mean + SEM. (D) Lungs for histological examination were harvested at d8 p.i. (5 mice/group). Leukocyte infiltration was assessed on H&E stained paraffin sections. Sections from two representative mice per group are shown. The scale bar indicates 200 um. Data is representative of two independent experiments.</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_1691_nihms294931f3.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_1691_nihms294931f2.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_1483_zh80170934270002.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_1483_zh80170934270001.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12877_pone0001911g002.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Figure 2 Splenic T cell hyperplasia and T cell size in p27 -/- Lck-Bcl-2 mice. A) Total splenic cells from mice of the indicated genotypes were isolated and stained with anti-B220-PE and anti-CD3-FITC antibodies as described in the Materials and Methods . The percentage of CD3-positive cells and the total number of splenic T cells (total # of splenic cells X %CD3) is shown. The data are representative of at least three mice from each genotype. B) The Mean Forward Scatter of CD3 positive splenic T cells was determined by staining with an anti-CD3 antibody as described in the Materials and Methods . The Mean+-SD of at least 5 mice is shown for the genotypes indicated. * P<0.01 versus both the p27 +/- and p27 -/- mice using the unpaired Students T test. The p27 +/- Lck-Bcl-2 mice were not significantly different than the P27 -/- Lck-Bcl-2 mice (P = 0.89).</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12876_zmb0170769470004.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12876_zmb0170769470003.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12876_zmb0170769470002.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_12876_zmb0170769470001.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/15045282-17030619-CD45R-B220-zmb0240664150005.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/15045282-17030619-CD45R-B220-zmb0240664150003.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_1365_zmb0240664150002.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_1365_zmb0240664150001.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/11045282-10454544-CD45R-B220-mb099028905a.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Flow Cytometry (Flow)" title="CD45R (B220) Antibody (17-0452-82) in Flow"> <figcaption itemprop="caption">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_19026_cancers-13-05019-g004.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody in Immunohistochemistry (IHC)" title="CD45R (B220) Antibody (17-0452-82) in IHC"> <figcaption itemprop="caption">Figure 4 Proof-of-mechanism study for TAX2 use as an anti-tumor immunomodulatory drug. The effects of TAX2 peptide treatment on the activation of an anti-tumor immune response were investigated in two syngeneic models of epithelial ovarian carcinoma. We inoculated 5 x 10 6 ID8 cells either subcutaneously or intraperitoneally to C57BL/6JRj mice in order to mimic primary tumor growth ( a - h ) and metastatic dissemination (peritoneal carcinosis, i - l ), respectively. TAX2 treatments (30 mg * kg -1 BW) vs. vehicle injections (0.9% NaCl) were performed thrice weekly for 4 and 8 weeks for the s.c. and i.p. ID8 models, respectively ( n = 11 per group for both models). ( a - h ) IHC staining of s.c. ovarian carcinoma allografts for the analysis of the vascular/lymphovascular features, as well as immune-cell-infiltration profile. ( a ) Representative microphotograph for CD31 immunostaining of intra-tumor vascular structures. Histogram displays results of automated quantification for the percent of CD31-positive pixels across the whole tumor section (mean +- SEM, Mann-Whitney U test; n.s., not significant). ( b ) Lymphatic vessel density analysis. Microscopic views are shown, while histogram displays the number of Lyve-1-positive functional lymphatic vessels in 5 high power fields (HPF), as determined by a pathologist who was blinded to the treatment (mean +- SEM, Mann-Whitney U test, * p < 0.05). ( c - f ) Macroscopic views (x20 magnification) of s.c. tumor allograft sections after</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/17045282-CD45R-(B220)-RA3-6B2-RE-AV-20170920122035.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody" title="CD45R (B220) Antibody (17-0452-82)"> <figcaption itemprop="caption">Staining of mouse splenocytes and bone marrow cells. As expected based on known relative expression patterns, CD45R (B220) clone RA3-6B2 stains subsets in both the splenocytes gate and the bone marrow lymphoid gate but not the bone marrow myeloid gate. Details: Balb/c bone marrow cells (left) and splenocytes (middle) were surface stained with CD45R (B220, clone RA3-6B2) followed by staining with 7-AAD. Viable bone marrow cells in the lymphoid (blue histogram) and myeloid (purple histogram) gates and viable splenocytes (orange histogram) were used for analysis. {RE}</figcaption> </figure> </div> <div> <hr> <figure itemprop="image" itemscope itemtype="http://schema.org/ImageObject"> <img src="https://www.thermofisher.com/antibody/images/650/tfs_14705_MMR-17-06-7701-g03.jpg?time=20240507?time=20240507" alt="CD45R (B220) Antibody" title="CD45R (B220) Antibody (17-0452-82)"> <figcaption itemprop="caption">Figure 4. MSC-CM treatment alleviates mature B lymphocyte infiltration into the kidneys following UUO. (A) Representative images of Sham + PBS, Sham + MSC-CM, UUO + PBS and UUO + MSC-CM mice 3 days following surgery. Scale bar=50 um. Data are presented as the mean +- standard deviation (n=6-7). (B) Representative flow cytometry images of renal B220 + CD19 + B lymphocyte cytometry of Sham + PBS, Sham + MSC-CM, UUO + PBS and UUO + MSC-CM mice 3 days following surgery. (C) Quantitative analysis of B220 staining and (D) quantitative analysis of renal B220 + CD19 + B lymphocyte cytometry. Data are presented as the means +- standard deviation (n=6). *P<0.05 vs. Sham + PBS group; $ P<0.05 vs. UUO + PBS group. MSC-CM, mesenchymal stem cell-conditioned media; Sham + PBS, sham-operated and PBS treated; Sham + MSC-CM, sham-operated and MSC-CM treated; UUO, unilateral ureteral obstruction; UUO + PBS, UUO model and PBS treated; UUO + MSC-CM, UUO model and MSC-CM treated. {TM}</figcaption> </figure> </div> </div> </noscript> <div id="tf-related-products-container-new"></div> <div class="product-details"> <div class="container"> <div class="row"> <div class="large-span-12 medium-span-12 small-span-12"> <h2 class="pdp-sub-heading product_details_heading">Product Details</h2></div> <div class="hidden-sku"> <h2>17-0452-82</h2> </div> <div class="product-detail-section tested-app-section new-tbl-design product-detail-section table-spec"> <div class="product-container-head"> <div class="product-item"> Applications </div> <div class="product-item dilution-lbl-head "> Tested Dilution </div> <div class="product-item published-applications"> Publications </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Immunohistochemistry (IHC)</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#IHC-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 5 publications</span> <span class="mobile-view">5 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Immunohistochemistry (Frozen) (IHC (F))</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#IHCF-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 6 publications</span> <span class="mobile-view">6 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>Flow Cytometry (Flow)</h2></div> <div class="product-item "> <span class="dilution-lbl">0.25 µg/test</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#Flow-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 182 publications</span> <span class="mobile-view">182 publications</span></a> </div> </div> <div class="product-container-body"> <div class="product-item"> <h2>ELISA (ELISA)</h2></div> <div class="product-item "> <span class="dilution-lbl dilution-lbl-dash">-</span> </div> <div class="product-item"> <a class="animated-scroll" onclick="window.THERMO_FISHER.pdp.inp.handleClickReferenceProductDetails(event,this,'a[href="#ELISA-content&quot]')" data-target="References" href="#references-component-id"> <span class="desktop-view">View 1 publication</span> <span class="mobile-view">1 publication</span></a> </div> </div> </div> <div class="product-detail-section tested-app-section new-tbl-design product-specific-section table-spec"> <div class="product-container-head"> <div class="product-item">Product Specifications</div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Species Reactivity</h2> </div> <div class="product-item left-flex-cls"> <span title="Homo sapiens">Human,</span> <span title="Mus musculus">Mouse</span> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Published species</h2> </div> <div class="product-item left-flex-cls"> <span>Fish,</span> <span>Human,</span> <span>Mouse</span> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2> Host/Isotype</h2> </div> <div class="product-item left-flex-cls"> <span title="Rattus">Rat / IgG2a, kappa</span> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Recommended Isotype Control</h2> </div> <div class="product-item left-flex-cls"> <a href="//www.thermofisher.com/antibody/product/17-4321-81"> Rat IgG2a kappa Isotype Control (eBR2a), APC, eBioscience™</a> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Class</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Monoclonal </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Type</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Antibody </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Clone</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> RA3-6B2 </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Conjugate</h2> </div> <div class="product-item left-flex-cls"> <a ng-if="$ctrl.checkConjugate('APC ') && '/us/en/home/life-science/cell-analysis/fluorophores/allophycocyanin.html?cid=bid_pca_aup_r01_co_cp1603_pjt0000_abs00000_0wm_tfs_il_crs_cs_s00_dye'.trim() != ''" href="/us/en/home/life-science/cell-analysis/fluorophores/allophycocyanin.html?cid=bid_pca_aup_r01_co_cp1603_pjt0000_abs00000_0wm_tfs_il_crs_cs_s00_dye" ng-attr-target="{{$ctrl.getRequestCustomLinkTarget()}}" class="conjugate-value">APC </a> <span ng-if="($ctrl.checkConjugate('APC ') && '/us/en/home/life-science/cell-analysis/fluorophores/allophycocyanin.html?cid=bid_pca_aup_r01_co_cp1603_pjt0000_abs00000_0wm_tfs_il_crs_cs_s00_dye'.trim() == '')" class="conjugate-value">APC </span> <span ng-if="!$ctrl.checkConjugate('APC ')" class="conjugate-value">APC </span> <div class="dropdown conjugate-dropdown"> <button class="btn-link conjugate-btn" type="button" data-toggle="dropdown"> View additional formats <span class="caret"></span> </button> <ul class="dropdown-menu dropdown-menu-fixed"> <li><a class="conjugate-color-padding" href="/antibody/product/14-0452-82"> Unconjugated <span class="conjugate-indicator" style="background-color:"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/53-0452-82"> Alexa Fluor 488 <span class="conjugate-indicator" style="background-color:#36FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/58-0452-82"> Alexa Fluor 532 <span class="conjugate-indicator" style="background-color:#B3FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/505-0452-82"> Alexa Fluor 561 <span class="conjugate-indicator" style="background-color:#E1FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/606-0452-82"> Alexa Fluor 660 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/56-0452-82"> Alexa Fluor 700 <span class="conjugate-indicator" style="background-color:#8D0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/47-0452-82"> APC-eFluor 780 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/13-0452-82"> Biotin <span class="conjugate-indicator" style="background-color:"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/363-0452-82"> Brilliant UV 395 <span class="conjugate-indicator" style="background-color:#8000A1"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/364-0452-82"> Brilliant UV 496 <span class="conjugate-indicator" style="background-color:#00FFFF"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/365-0452-82"> Brilliant UV 563 <span class="conjugate-indicator" style="background-color:#C3FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/366-0452-82"> Brilliant UV 615 <span class="conjugate-indicator" style="background-color:#FF8900"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/376-0452-82"> Brilliant UV 661 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/367-0452-82"> Brilliant UV 737 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/368-0452-82"> Brilliant UV 805 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/404-0452-82"> Brilliant Violet 421 <span class="conjugate-indicator" style="background-color:#5400FF"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/414-0452-82"> Brilliant Violet 480 <span class="conjugate-indicator" style="background-color:#00C0FF"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/406-0452-82"> Brilliant Violet 605 <span class="conjugate-indicator" style="background-color:#FFAD00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/416-0452-82"> Brilliant Violet 650 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/407-0452-82"> Brilliant Violet 711 <span class="conjugate-indicator" style="background-color:#820000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/417-0452-82"> Brilliant Violet 786 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/48-0452-82"> eFluor 450 <span class="conjugate-indicator" style="background-color:#0028FF"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/69-0452-82"> eFluor 506 <span class="conjugate-indicator" style="background-color:#00FF54"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/41-0452-80"> eFluor 570 <span class="conjugate-indicator" style="background-color:#E1FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/42-0452-82"> eFluor 615 <span class="conjugate-indicator" style="background-color:#FF8900"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/50-0452-82"> eFluor 660 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/11-0452-82"> FITC <span class="conjugate-indicator" style="background-color:#1FFF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/16-0452-82"> Functional Grade <span class="conjugate-indicator" style="background-color:"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M011T02B01-A"> NovaFluor Blue 510 <span class="conjugate-indicator" style="background-color:#00FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M011T02B02-A"> NovaFluor Blue 530 <span class="conjugate-indicator" style="background-color:#5EFF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M011T02B04-A"> NovaFluor Blue 585 <span class="conjugate-indicator" style="background-color:#FFEF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M011T02B05-A"> NovaFluor Blue 610-30S <span class="conjugate-indicator" style="background-color:#FF8900"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M011T02B07-A"> NovaFluor Blue 660-40S <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M011T03B10-A"> NovaFluor Blue 725 <span class="conjugate-indicator" style="background-color:#610000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M011T03B11-A"> NovaFluor Blue 760 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M011T03B12-A"> NovaFluor Blue 800 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M011T02R03-A"> NovaFluor Red 700 <span class="conjugate-indicator" style="background-color:#8D0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M011T03U01-A"> NovaFluor UV 765 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M011T03V01-A"> NovaFluor Violet 690 <span class="conjugate-indicator" style="background-color:#AB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M011T03V03-A"> NovaFluor Violet 800 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M011T02Y01-A"> NovaFluor Yellow 570 <span class="conjugate-indicator" style="background-color:#E1FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M011T02Y02-A"> NovaFluor Yellow 590 <span class="conjugate-indicator" style="background-color:#FFDF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M011T02Y04-A"> NovaFluor Yellow 660 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/M011T03Y09-A"> NovaFluor Yellow 810 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/12-0452-82"> PE <span class="conjugate-indicator" style="background-color:#F0FF00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/15-0452-82"> PE-Cyanine5 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/35-0452-82"> PE-Cyanine5.5 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/25-0452-82"> PE-Cyanine7 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/61-0452-82"> PE-eFluor 610 <span class="conjugate-indicator" style="background-color:#FF9B00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/45-0452-82"> PerCP-Cyanine5.5 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/46-0452-82"> PerCP-eFluor 710 <span class="conjugate-indicator" style="background-color:#820000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/62-0452-82"> Super Bright 436 <span class="conjugate-indicator" style="background-color:#3D00FF"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/63-0452-82"> Super Bright 600 <span class="conjugate-indicator" style="background-color:#FFBE00"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/64-0452-82"> Super Bright 645 <span class="conjugate-indicator" style="background-color:#DB0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/67-0452-82"> Super Bright 702 <span class="conjugate-indicator" style="background-color:#8D0000"></span> </a></li> <li><a class="conjugate-color-padding" href="/antibody/product/78-0452-82"> Super Bright 780 <span class="conjugate-indicator" style="background-color:#808080"></span> </a></li> <li class="drop-down-link-ctnr"> <a class="conjugate-dropdown-link" href="/us/en/home/global/forms/antibody-conjugates-custom-form.html" ng-attr-target="$ctrl.getRequestCustomLinkTarget()">Request custom conjugation <svg class="svg-icon external-link-icon" ng-if="$ctrl.showExternalLinkIcon()"> <use href="#external-link"></use> </svg> </a> </li> </ul> </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Excitation/Emission Max</h2> </div> <div class="product-item left-flex-cls"> <span>651/660 nm</span> <a target="_blank" class="spectra-view" href="/order/fluorescence-spectraviewer?SID=srch-svtool&UID=803ph75"> <span class="view-spectra"> View spectra</span> <span class="spectra-view-icon "><img src="/order/genome-database/assets/img/spectra.png" alt="spectra"/></span> </a> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Form</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Liquid </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Concentration</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> 0.2 mg/mL </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Purification</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Affinity chromatography </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Storage buffer</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> PBS, pH 7.2 </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Contains</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> 0.09% sodium azide </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Storage conditions</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> 4° C, store in dark, DO NOT FREEZE! </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"> <h2>Shipping conditions</h2> </div> <div class="product-item left-flex-cls"> <div class="product-value"> Ambient (domestic); Wet ice (international) </div> </div> </div> <div class="product-container-body pcb1-2"> <div class="product-item"><h2>RRID <span id="rrid-tooltip" class="rrid-tooltip-icon" ng-include="'/order/genome-database/webapp/assets/core/img/svg/mono_tooltip.svg'" data-toggle="tooltip" ng-click="$ctrl.showRridTooltip()" close-tooltip="$ctrl.closeRridTooltip()" title="Research Resource Identifiers (#RRID) are ID numbers assigned to help researchers cite key resources in the biomedical literature to improve transparency of research methods."> </span></h2> </div> <div class="product-item left-flex-cls">AB_469395</div> </div> </div> <div class="product-specific-details"> <div class="product-specific-details-tbl product-specific-add-border" > <div class="product-info-para"> <h4 class="product-info-para-heading"> Product Specific Information </h4> <p>Description: The RA3-6B2 monoclonal antibody reacts with exon A-restricted isoform of mouse CD45, a 220 kDa surface molecule. CD45R/B220 epitope is mainly expressed by the B cell lineage from early Pro-B to mature B cells. However, some activated T cells, lymphokine activated killer cells (LAK), NK cell progenitors in the bone marrow, and T cells of the lpr/lpr mutant mouse also express this antigen.<br /><br />Applications Reported: This RA3-6B2 antibody has been reported for use in flow cytometric analysis.<br /><br />Applications Tested: This RA3-6B2 antibody has been tested by flow cytometric analysis of mouse spleen cells. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.<br /><br />Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.<br /><br />Filtration: 0.2 µm post-manufacturing filtered.</p> </div> <div class="product-info-para"> <h4 class="product-info-para-heading"> Target Information </h4> <p class="product-specific-target-info">CD45R (PTPRC) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. CD45 contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. CD45 is specifically expressed in hematopoietic cells and has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists in multiple isoforms as a result of alternative splicing, and these isoforms differ in their extracellular domains, but share identical transmembrane and cytoplasmic domains. Further, these CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. In addition to its role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. Diseases associated with CD45 dysfunction include Severe Combined Immunodeficiency (T-cell negative, B-Cell Negative) and Hepatitis C.</p> </div> <p class="product-details-regulatoryStmt">For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.</p> </div> <div class="product-detail-panel-builder"> <tf-promo-ad ng-if="$ctrl.showPromoAd" show-promo-ad="$ctrl.showPromoAd"></tf-promo-ad> <div class="product-detail-video"> <div tf-video-player-new video-id="6206990159001" player-width="368" player-height="210"></div> <div class="panel-builder"> <h4 class="product-info-para-heading"> How to use the Panel Builder </h4> <p>Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.</p> </div> </div> </div> </div> </div> </div> </div> <div id="rootPdpDocLoader"></div> <div id="tf-related-products-container" ng-show="emptyRelatedProductsWidget === false" > <related-products-container ng-if="showRelatedProductsWidget === true" base-url="'/api/magellan/related-products-ui/widget/v2/'" product-type="'antibody'" product-sub-type="'primary'" product-id="'17-0452-82'" country-code="'sg'" iso-language="'en'" > </related-products-container> </div> <div class="tf-pdp-divider" ng-if="emptyRelatedProductsWidget === false" ></div> <div class="references reference-section-3" id="references-component-id"> <div id="references-section-id"> <reference-section ng-if="loadReferences" default-display-card-limit="3" reference-count="194" sub-type="'Antibody'" application-data='{"citationApplications":[{"applicationAbbreviation":"IHC","citations":[{"title":"Self-Assembly of Immune Signals to Program Innate Immunity through Rational Adjuvant Design.","summary":"17-0452-82 was used in Immunohistochemistry to show activating multiple innate immune pathways drives robust responses in infection and cancer.","authors":"Bookstaver ML,Zeng Q,Oakes RS,Kapnick SM,Saxena V,Edwards C,Venkataraman N,Black SK,Zeng X,Froimchuk E,Gebhardt T,Bromberg JS,Jewell CM","literatureId":"36373708","journal":"Advanced science (Weinheim, Baden-Wurttemberg, Germany)","volume":"10","publishedDate":"Nov 14, 2022, 5:00:00 AM","url":"http://dx.doi.org/10.1002/advs.202202393","benchSci":false,"imageURL":"https://www.thermofisher.com/antibody/images/250/null?time\u003d20240507","journalAbbr":"Adv Sci (Weinh)","sortOrder":8,"species":["Mouse"],"speciesDilutionMap":{"Mouse":"1:400"},"abbreviationToNameMap":{"IHC":"Immunohistochemistry"},"newSpeciesDilutionMap":{"Mouse~IHC~1:400":"1:400"}},{"title":"Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity.","summary":"Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Immunohistochemistry","authors":"Jeanne A,Sarazin T,Charlé M,Moali C,Fichel C,Boulagnon-Rombi C,Callewaert M,Andry MC,Diesis E,Delolme F,Rioult D,Dedieu S","literatureId":"34638503","journal":"Cancers","volume":"13","publishedDate":"Oct 7, 2021, 4:00:00 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Immunol"],"speciesMap":{"Mouse":1},"journalsMap":{"J Immunol":1},"sortedMap":{}}]}'></reference-section> </div> <noscript> <div itemscope itemtype="https://schema.org/ScholarlyArticle"> <h2>Product References</h2> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37587343"> <div itemprop="name">Platelet factors attenuate inflammation and rescue cognition in ageing.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">Schroer AB,Ventura PB,Sucharov J,Misra R,Chui MKK,Bieri G,Horowitz AM,Smith LK,Encabo K,Tenggara I,Couthouis J,Gross JD,Chan JM,Luke A,Villeda SA</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Aug 01 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36821441"> <div itemprop="name">TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Matsuda S,Revandkar A,Dubash TD,Ravi A,Wittner BS,Lin M,Morris R,Burr R,Guo H,Seeger K,Szabolcs A,Che D,Nieman L,Getz GA,Ting DT,Lawrence MS,Gainor J,Haber DA,Maheswaran S</div> <div itemprop="description">17-0452-82 was used in Flow Cytometry to investigate whether TGF-β in the hypoxic tumor microenvironment (TME) induces senescence in cancer and how the ensuing senescence-associated secretory phenotype (SASP) remodels the cellular TME to influence immune checkpoint inhibitor (ICI) responses.</div> <div itemprodp="datePublished">Tue Mar 28 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/37102608"> <div itemprop="name">Inactivation of p53 provides a competitive advantage to del(5q) myelodysplastic syndrome hematopoietic stem cells during inflammation.</div> </a> <div itemprop="about">Haematologica</div> <div itemprop="author">Muto T,Walker CS,Agarwal P,Vick E,Sampson A,Choi K,Niederkorn M,Ishikawa C,Hueneman K,Varney M,Starczynowski DT</div> <div itemprop="description">17-0452-82 was used in Flow cytometry/Cell sorting to investigate the effects of inflammation on hematopoietic stem and progenitor cells (HSPC) in the context of myelodysplastic syndromes (MDS), particularly the del(5q) subtype.</div> <div itemprodp="datePublished">Sun Oct 01 00:00:00 EDT 2023</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36121858"> <div itemprop="name">RIPK3 and caspase 8 collaborate to limit herpes simplex encephalitis.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Guo H,Koehler HS,Mocarski ES,Dix RD</div> <div itemprop="description">17-0452-82 was used in Flow cytometry/Cell sorting to show that kinase-independent induction of inflammation by RIPK3 in collaboration with caspase 8 restricts virus replication within the brain during HSE neuropathogenesis.</div> <div itemprodp="datePublished">Thu Sep 01 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35393948"> <div itemprop="name">Transient expansion and myofibroblast conversion of adipogenic lineage precursors mediate bone marrow repair after radiation.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Zhong L,Yao L,Holdreith N,Yu W,Gui T,Miao Z,Elkaim Y,Li M,Gong Y,Pacifici M,Maity A,Busch TM,Joeng KS,Cengel K,Seale P,Tong W,Qin L</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Apr 08 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35985991"> <div itemprop="name">Lenvatinib for effectively treating antiangiogenic drug-resistant nasopharyngeal carcinoma.</div> </a> <div itemprop="about">Cell death & disease</div> <div itemprop="author">Sun Q,Wang Y,Ji H,Sun X,Xie S,Chen L,Li S,Zeng W,Chen R,Tang Q,Zuo J,Hou L,Hosaka K,Lu Y,Liu Y,Ye Y,Yang Y</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Aug 19 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35235365"> <div itemprop="name">Tet-mediated DNA demethylation regulates specification of hematopoietic stem and progenitor cells during mammalian embryogenesis.</div> </a> <div itemprop="about">Science advances</div> <div itemprop="author">Ma L,Tang Q,Gao X,Lee J,Lei R,Suzuki M,Zheng D,Ito K,Frenette PS,Dawlaty MM</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Mar 04 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/36373708"> <div itemprop="name">Self-Assembly of Immune Signals to Program Innate Immunity through Rational Adjuvant Design.</div> </a> <div itemprop="about">Advanced science (Weinheim, Baden-Wurttemberg, Germany)</div> <div itemprop="author">Bookstaver ML,Zeng Q,Oakes RS,Kapnick SM,Saxena V,Edwards C,Venkataraman N,Black SK,Zeng X,Froimchuk E,Gebhardt T,Bromberg JS,Jewell CM</div> <div itemprop="description">17-0452-82 was used in Immunohistochemistry to show activating multiple innate immune pathways drives robust responses in infection and cancer.</div> <div itemprodp="datePublished">Mon Nov 14 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35882236"> <div itemprop="name">Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Dong X,Limjunyawong N,Sypek EI,Wang G,Ortines RV,Youn C,Alphonse MP,Dikeman D,Wang Y,Lay M,Kothari R,Vasavda C,Pundir P,Goff L,Miller LS,Lu W,Garza LA,Kim BS,Archer NK,Dong X</div> <div itemprop="description">17-0452-82 was used in Flow Cytometry to demonstrate the importance of epithelial-neutrophil signaling via the defensin-Mrgpra2 axis in maintaining healthy skin ecology and promoting antibacterial host defense.</div> <div itemprodp="datePublished">Tue Sep 13 00:00:00 EDT 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35260749"> <div itemprop="name">Sphk2 deletion is involved in structural abnormalities and Th17 response but does not aggravate colon inflammation induced by sub-chronic stress.</div> </a> <div itemprop="about">Scientific reports</div> <div itemprop="author">Martín-Hernández D,Gutiérrez IL,González-Prieto M,MacDowell KS,Robledo-Montaña J,Tendilla-Beltrán H,Calleja-Rodríguez N,Bris ÁG,Ulecia-Morón C,Moreno B,Caso JR,García-Bueno B,Rodrigues-Mascarenhas S,Marín-Jiménez I,Leza JC,Menchén L</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Mar 08 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35017148"> <div itemprop="name">B cells imprint adoptively transferred CD8<sup>+</sup> T cells with enhanced tumor immunity.</div> </a> <div itemprop="about">Journal for immunotherapy of cancer</div> <div itemprop="author">Smith AS,Knochelmann HM,Wyatt MM,Rangel Rivera GO,Rivera-Reyes AM,Dwyer CJ,Ware MB,Cole AC,Neskey DM,Rubinstein MP,Liu B,Thaxton JE,Bartee E,Paulos CM</div> <div itemprop="description">17-0452-82 was used in Flow cytometry/Cell sorting to investigate how tumor-specific murine CD8+ T cells and human tumor infiltrating lymphocytes (TILs) are impacted when expanded ex vivo with the TLR9 agonist CpG.</div> <div itemprodp="datePublished">Sat Jan 01 00:00:00 EST 2022</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/35045331"> <div itemprop="name">TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting 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itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Ho TT,Dellorusso PV,Verovskaya EV,Bakker ST,Flach J,Smith LK,Ventura PB,Lansinger OM,Hérault A,Zhang SY,Kang YA,Mitchell CA,Villeda SA,Passegué E</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jul 05 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33207226"> <div itemprop="name">Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population.</div> </a> <div itemprop="about">Developmental cell</div> <div itemprop="author">Kasashima H,Duran A,Martinez-Ordoñez A,Nakanishi Y,Kinoshita H,Linares JF,Reina-Campos M,Kudo Y,L'Hermitte A,Yashiro M,Ohira M,Bao F,Tauriello DVF,Batlle E,Diaz-Meco MT,Moscat J</div> <div itemprop="description">17-0452-82 was used in Immunohistochemistry 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itemprop="description">17-0452-82 was used in Flow Cytometry to conclude that the wide variation in inflammatory reactions associated with TNFRSF13B diversity suggests polymorphisms could underlie variation in host defense and explosive inflammatory responses that sometimes enhance morbidity associated with immune responses.</div> <div itemprodp="datePublished">Wed Sep 08 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/34820606"> <div itemprop="name">Myeloid cell subsets that express latency-associated peptide promote cancer growth by modulating T cells.</div> </a> <div itemprop="about">iScience</div> <div itemprop="author">Gabriely G,Ma D,Siddiqui S,Sun L,Skillin NP,Abou-El-Hassan H,Moreira TG,Donnelly D,da Cunha AP,Fujiwara M,Walton LR,Patel A,Krishnan R,Levine SS,Healy BC,Rezende RM,Murugaiyan G,Weiner HL</div> <div itemprop="description">17-0452-82 was used in Flow cytometry/Cell sorting to identify a previously unknown function by which LAPHi MCs promote tumor growth and offer therapeutic intervention to target these cells in cancer.</div> <div itemprodp="datePublished">Fri Nov 19 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33296685"> <div itemprop="name">SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Lederer K,Castaño D,Gómez Atria D,Oguin TH,Wang S,Manzoni TB,Muramatsu H,Hogan MJ,Amanat F,Cherubin P,Lundgreen KA,Tam YK,Fan SHY,Eisenlohr LC,Maillard I,Weissman D,Bates P,Krammer F,Sempowski GD,Pardi N,Locci M</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Dec 15 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32313245"> <div itemprop="name">Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs.</div> </a> <div itemprop="about">Nature immunology</div> <div itemprop="author">Muto T,Walker CS,Choi K,Hueneman K,Smith MA,Gul Z,Garcia-Manero G,Ma A,Zheng Y,Starczynowski DT</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to show that chronic inflammation is a determinant for the competitive advantage of myelodysplastic syndrome (MDS) hematopoietic stem and progenitor cells (HSPCs) and for disease progression.</div> <div itemprodp="datePublished">Fri May 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31886826"> <div itemprop="name">Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Kang YA,Pietras EM,Passegué E</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Mar 02 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32945574"> <div itemprop="name">Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis.</div> </a> <div itemprop="about">The EMBO journal</div> <div itemprop="author">Kusnadi EP,Trigos AS,Cullinane C,Goode DL,Larsson O,Devlin JR,Chan KT,De Souza DP,McConville MJ,McArthur GA,Thomas G,Sanij E,Poortinga G,Hannan RD,Hannan KM,Kang J,Pearson RB</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to identify key molecular mechanisms underpinning the response of blood cancers to selective inhibition of ribosome biogenesis and define metabolic vulnerabilities that will facilitate the rational design of more effective regimens for Pol I-directed therapies.</div> <div itemprodp="datePublished">Mon Nov 02 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32353176"> <div itemprop="name">MOSPD2 is a therapeutic target for the treatment of CNS inflammation.</div> </a> <div itemprop="about">Clinical and experimental immunology</div> <div itemprop="author">Yacov N,Kafri P,Salem Y,Propheta-Meiran O,Feldman B,Breitbart E,Mendel I</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to study the therapeutic potential of MOSPD2 in central nervous system disease.</div> <div itemprodp="datePublished">Sat Aug 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31165249"> <div itemprop="name">High-fat diet induced central adiposity (visceral fat) is associated with increased fibrosis and decreased immune cellularity of the mesenteric lymph node in mice.</div> </a> <div itemprop="about">European journal of nutrition</div> <div itemprop="author">Magnuson AM,Regan DP,Booth AD,Fouts JK,Solt CM,Hill JL,Dow SW,Foster MT</div> <div itemprop="description">17-0452-82 was used in Flow Cytometry to investigate if lymph nodes are inherently distinct and differentially respond to diet-induced obesity much like the adipose depots they reside in.</div> <div itemprodp="datePublished">Mon Jun 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32535543"> <div itemprop="name">Generation and characterization of the Eµ-Irf8 mouse model.</div> </a> <div itemprop="about">Cancer genetics</div> <div itemprop="author">Qiu Z,Holder KN,Lin AP,Myers J,Jiang S,Gorena KM,Kinney MC,Aguiar RCT</div> <div itemprop="description">17-0452-82 was used in Flow Cytometry to investigate the role of IRF8 in B- cell lymphoma biology using a transgenic mouse model.</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32943626"> <div itemprop="name">The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Sep 17 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33363536"> <div itemprop="name">Myeloid Cell CK2 Regulates Inflammation and Resistance to Bacterial Infection.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Larson SR,Bortell N,Illies A,Crisler WJ,Matsuda JL,Lenz LL</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jul 27 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33133093"> <div itemprop="name">Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Myers DR,Abram CL,Wildes D,Belwafa A,Welsh AMN,Schulze CJ,Choy TJ,Nguyen T,Omaque N,Hu Y,Singh M,Hansen R,Goldsmith MA,Quintana E,Smith JAM,Lowell CA</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jun 14 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32411498"> <div itemprop="name">G protein-coupled receptor 68 increases the number of B lymphocytes.</div> </a> <div itemprop="about">American journal of blood research</div> <div itemprop="author">He X,Feng S,Hawkins C,Lawley L,Fan W,Xu Y,Zha XM,Fang J</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to indicate that Gpr68 expression is upregulated in hematopoietic cells upon aging and during hematopoietic regeneration that ends up with increased number of B lymphocytes.</div> <div itemprodp="datePublished">Mon Sep 28 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33111080"> <div itemprop="name">Analysis of Myeloid Cells in Mouse Tissues with Flow Cytometry.</div> </a> <div itemprop="about">STAR protocols</div> <div itemprop="author">Liu Z,Gu Y,Shin A,Zhang S,Ginhoux F</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jun 19 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/33224133"> <div itemprop="name">TNFAIP3 Plays a Role in Aging of the Hematopoietic System.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Smith MA,Culver-Cochran AE,Adelman ER,Rhyasen GW,Ma A,Figueroa ME,Starczynowski DT</div> <div itemprop="description">17-0452-82 was used in Flow Cytometry to find that the expression of A20 is significantly reduced in aged hematopoietic stem and progenitor cells (HSPC) as compared to young HSPC.</div> <div itemprodp="datePublished">Wed Apr 28 00:00:00 EDT 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31914399"> <div itemprop="name">Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Hidalgo San Jose L,Sunshine MJ,Dillingham CH,Chua BA,Kruta M,Hong Y,Hatters DM,Signer RAJ</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to show that hematopoietic stem cells (HSCs) are dependent on low protein synthesis to maintain proteostasis, which promotes their self-renewal.</div> <div itemprodp="datePublished">Tue Jan 07 00:00:00 EST 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32290362"> <div itemprop="name">Glucocorticoids Promote the Onset of Acute Experimental Colitis and Cancer by Upregulating mTOR Signaling in Intestinal Epithelial Cells.</div> </a> <div itemprop="about">Cancers</div> <div itemprop="author">Zhang Z,Dong L,Jia A,Chen X,Yang Q,Wang Y,Wang Y,Liu R,Cao Y,He Y,Bi Y,Liu G</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to indicate that glucocorticoid-induced mTOR signaling in epithelial cells is required in the early stages of acute ulcerative colitis by modulating the dynamics of innate immune cell recruitment and activation.</div> <div itemprodp="datePublished">Sat Apr 11 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32294433"> <div itemprop="name">Diverse CD8 T Cell Responses to Viral Infection Revealed by the Collaborative Cross.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Martin MD,Sompallae R,Winborn CS,Harty JT,Badovinac VP</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to advance the utility of the Collaborative Cross (CC) as a tool to analyze the immune response to viral infection.</div> <div itemprodp="datePublished">Tue Apr 14 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32538902"> <div itemprop="name">Retroviral Overexpression of CXCR4 on Murine B-1a Cells and Adoptive Transfer for Targeted B-1a Cell Migration to the Bone Marrow and IgM Production.</div> </a> <div itemprop="about">Journal of visualized experiments : JoVE</div> <div itemprop="author">Upadhye A,Marshall M,Garmey JC,Bender TP,McNamara C</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to describe a method to target B-1a cell migration to the bone marrow by retroviral-mediated overexpression of the C-X-C motif chemokine receptor 4 (CXCR4).</div> <div itemprodp="datePublished">Sun May 31 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32433959"> <div itemprop="name">Crucial Roles of the RIP Homotypic Interaction Motifs of RIPK3 in RIPK1-Dependent Cell Death and Lymphoproliferative Disease.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Zhang H,Wu X,Li X,Li M,Li F,Wang L,Zhang X,Zhang Y,Luo Y,Wang H,Jiang Y,Zhang H</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to reveal a previously unidentified physiological function of RHIM of RIPK3 in regulating RIPK1-dependent cell death and lymphoproliferative disease.</div> <div itemprodp="datePublished">Tue May 19 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/32348770"> <div itemprop="name">Id1 and Id3 Maintain Steady-State Hematopoiesis by Promoting Sinusoidal Endothelial Cell Survival and Regeneration.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Gadomski S,Singh SK,Singh S,Sarkar T,Klarmann KD,Berenschot M,Seaman S,Jakubison B,Gudmundsson KO,Lockett S,Keller JR</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to investigate the effects of loss of ld genes on adult endothelial cell.</div> <div itemprodp="datePublished">Tue Apr 28 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31806786"> <div itemprop="name">Targeted selection of HIV-specific antibody mutations by engineering B cell maturation.</div> </a> <div itemprop="about">Science (New York, N.Y.)</div> <div itemprop="author">Saunders KO,Wiehe K,Tian M,Acharya P,Bradley T,Alam SM,Go EP,Scearce R,Sutherland L,Henderson R,Hsu AL,Borgnia MJ,Chen H,Lu X,Wu NR,Watts B,Jiang C,Easterhoff D,Cheng HL,McGovern K,Waddicor P,Chapdelaine-Williams A,Eaton A,Zhang J,Rountree W,Verkoczy L,Tomai M,Lewis MG,Desaire HR,Edwards RJ,Cain DW,Bonsignori M,Montefiori D,Alt FW,Haynes BF</div> <div itemprop="description">17-0452-82 was used in Flow Cytometry to study the efficacy of vaccinations with immunogens which bind to bnAb B cell precursors in initiating bnAB B cell development.</div> <div itemprodp="datePublished">Fri Dec 06 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30880025"> <div itemprop="name">Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics.</div> </a> <div itemprop="about">Cell stem cell</div> <div itemprop="author">Ni F,Yu WM,Wang X,Fay ME,Young KM,Qiu Y,Lam WA,Sulchek TA,Cheng T,Scadden DT,Qu CK</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to show that Ptpn21 maintains cellular mechanics, which is correlated with its important functions in HSC niche retention and preservation of hematopoietic regeneration capacity.</div> <div itemprodp="datePublished">Thu Apr 04 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30530755"> <div itemprop="name">Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Chen Z,Amro EM,Becker F,Hölzer M,Rasa SMM,Njeru SN,Han B,Di Sanzo S,Chen Y,Tang D,Tao S,Haenold R,Groth M,Romanov VS,Kirkpatrick JM,Kraus JM,Kestler HA,Marz M,Ori A,Neri F,Morita Y,Rudolph KL</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to determine hematopoietic stem cell function is limited by Rad21/cohesin-mediated NF-kB signaling during aging.</div> <div itemprodp="datePublished">Mon Jan 07 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31481966"> <div itemprop="name">Tpl2 Protects Against Fulminant Hepatitis Through Mobilization of Myeloid-Derived Suppressor Cells.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Xu J,Pei S,Wang Y,Liu J,Qian Y,Huang M,Zhang Y,Xiao Y</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Oct 14 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31089128"> <div itemprop="name">Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Ramakrishna C,Kujawski M,Chu H,Li L,Mazmanian SK,Cantin EM</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue May 14 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31089128"> <div itemprop="name">Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Ramakrishna C,Kujawski M,Chu H,Li L,Mazmanian SK,Cantin EM</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue May 14 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30943405"> <div itemprop="name">The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Adane B,Ye H,Khan N,Pei S,Minhajuddin M,Stevens BM,Jones CL,D'Alessandro A,Reisz JA,Zaberezhnyy V,Gasparetto M,Ho TC,Kelly KK,Myers JR,Ashton JM,Siegenthaler J,Kume T,Campbell EL,Pollyea DA,Becker MW,Jordan CT</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Apr 02 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30893599"> <div itemprop="name">Nidogen-1 Contributes to the Interaction Network Involved in Pro-B Cell Retention in the Peri-sinusoidal Hematopoietic Stem Cell Niche.</div> </a> <div itemprop="about">Cell reports</div> <div itemprop="author">Balzano M,De Grandis M,Vu Manh TP,Chasson L,Bardin F,Farina A,Sergé A,Bidaut G,Charbord P,Hérault L,Bailly AL,Cartier-Michaud A,Boned A,Dalod M,Duprez E,Genever P,Coles M,Bajenoff M,Xerri L,Aurrand-Lions M,Schiff C,Mancini SJC</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to study pro-B cells in their support of stroll cells and their interaction network allowing their retention.</div> <div itemprodp="datePublished">Tue Mar 19 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/31462647"> <div itemprop="name">Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Sasaki K,Himeno A,Nakagawa T,Sasaki Y,Kiyonari H,Iwai K</div> <div itemprop="description">17-0452-82 was used in Flow Cytometry to show that T cell-mediated killing and sequential autoinflammation are common and crucial for pathogenic diversity during T cell-mediated autoimmune responses.</div> <div itemprodp="datePublished">Wed Aug 28 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29736022"> <div itemprop="name">Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche.</div> </a> <div itemprop="about">Nature medicine</div> <div itemprop="author">Maryanovich M,Zahalka AH,Pierce H,Pinho S,Nakahara F,Asada N,Wei Q,Wang X,Ciero P,Xu J,Leftin A,Frenette PS</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Jun 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29909986"> <div itemprop="name">Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.</div> </a> <div itemprop="about">Cell</div> <div itemprop="author">Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jun 28 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29562201"> <div itemprop="name">Cbl Ubiquitin Ligases Control B Cell Exit from the Germinal-Center Reaction.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Li X,Gadzinsky A,Gong L,Tong H,Calderon V,Li Y,Kitamura D,Klein U,Langdon WY,Hou F,Zou YR,Gu H</div> <div itemprop="description">17-0452-82 was used in Flow Cytometry to show that deleting E3 ubiquitin ligases Cbl and Cbl-b (Cbls) in GC B cells results in the early exit of high-affinity antigen-specific B cells from the GC reaction and thus impaired clonal expansion.</div> <div itemprodp="datePublished">Tue Mar 20 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29202466"> <div itemprop="name">Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Zhao B,Mei Y,Cao L,Zhang J,Sumagin R,Yang J,Gao J,Schipma MJ,Wang Y,Thorsheim C,Zhao L,Stalker T,Stein B,Wen QJ,Crispino JD,Abrams CS,Ji P</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to identify pleckstrin-2 as an effector of the JAK2/STAT5 pathway and a key factor in the pathogenesis of JAK2V617F-induced myeloproliferative neoplasms.</div> <div itemprodp="datePublished">Tue Jan 02 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29623080"> <div itemprop="name">Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Liu R,King A,Bouillet P,Tarlinton DM,Strasser A,Heierhorst J</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed May 01 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29298882"> <div itemprop="name">Host Tumor Suppressor p18<sup>INK4c</sup> Functions as a Potent Cell-Intrinsic Inhibitor of Murine Gammaherpesvirus 68 Reactivation and Pathogenesis.</div> </a> <div itemprop="about">Journal of virology</div> <div itemprop="author">Niemeyer BF,Oko LM,Medina EM,Oldenburg DG,White DW,Cool CD,Clambey ET,van Dyk LF</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Mar 15 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29206332"> <div itemprop="name">Inactivation of mTORC1 Signaling in Osterix-Expressing Cells Impairs B-cell Differentiation.</div> </a> <div itemprop="about">Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research</div> <div itemprop="author">Wang Y,Xiao M,Tao C,Chen J,Wang Z,Yang J,Chen Z,Zou Z,Liu A,Cai D,Jiang Y,Ding C,Li M,Bai X</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sun Apr 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29620281"> <div itemprop="name">Bone marrow‑derived mesenchymal stem cell‑conditioned medium attenuates tubulointerstitial fibrosis by inhibiting monocyte mobilization in an irreversible model of unilateral ureteral obstruction.</div> </a> <div itemprop="about">Molecular medicine reports</div> <div itemprop="author">Zheng J,Wang Q,Leng W,Sun X,Peng J</div> <div itemprop="description">17-0452-82 was used in Flow Cytometry to identify a potential mechanism of MSC‚CM in ameliorating the UUO‚kidney.</div> <div itemprodp="datePublished">Fri Jun 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29434774"> <div itemprop="name">Tanshinone IIA and Astragaloside IV promote the angiogenesis of mesenchymal stem cell-derived endothelial cell-like cells via upregulation of <i>Cx37</i>, <i>Cx40</i> and <i>Cx43</i>.</div> </a> <div itemprop="about">Experimental and therapeutic medicine</div> <div itemprop="author">Li Z,Zhang S,Cao L,Li W,Ye YC,Shi ZX,Wang ZR,Sun LX,Wang JW,Jia LT,Wang W</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Feb 01 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29925839"> <div itemprop="name">miR-143/145 differentially regulate hematopoietic stem and progenitor activity through suppression of canonical TGFβ signaling.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Lam J,van den Bosch M,Wegrzyn J,Parker J,Ibrahim R,Slowski K,Chang L,Martinez-Høyer S,Condorelli G,Boldin M,Deng Y,Umlandt P,Fuller M,Karsan A</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jun 20 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30687320"> <div itemprop="name">Dysregulated TRAF3 and BCL2 Expression Promotes Multiple Classes of Mature Non-hodgkin B Cell Lymphoma in Mice.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Perez-Chacon G,Adrados M,Vallejo-Cremades MT,Lefebvre S,Reed JC,Zapata JM</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Oct 25 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/30455690"> <div itemprop="name">ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Glal D,Sudhakar JN,Lu HH,Liu MC,Chiang HY,Liu YC,Cheng CF,Shui JW</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Sep 26 00:00:00 EDT 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29897995"> <div itemprop="name">Orally administered heat-killed Lactobacillus paracasei MCC1849 enhances antigen-specific IgA secretion and induces follicular helper T cells in mice.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Arai S,Iwabuchi N,Takahashi S,Xiao JZ,Abe F,Hachimura S</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to investigate the effects of orally administered heat-killed MCC1849 on IgA production in the intestine and on Tfh cell induction in vivo.</div> <div itemprodp="datePublished">Wed Jan 02 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29324880"> <div itemprop="name">EDAG promotes the expansion and survival of human CD34+ cells.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Zhao K,Zheng WW,Dong XM,Yin RH,Gao R,Li X,Liu JF,Zhan YQ,Yu M,Chen H,Ge CH,Ning HM,Yang XM,Li CY</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to provide novel insight into EDAG in regulation of expansion and survival of human hematopoietic stem/progenitor cells.</div> <div itemprodp="datePublished">Tue Feb 06 00:00:00 EST 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29501838"> <div itemprop="name">Adipose tissue extrinsic factor: Obesity-induced inflammation and the role of the visceral lymph node.</div> </a> <div itemprop="about">Physiology & behavior</div> <div itemprop="author">Magnuson AM,Fouts JK,Regan DP,Booth AD,Dow SW,Foster MT</div> <div itemprop="description">17-0452-82 was used in Flow cytometry/Cell sorting to elucidate how the lymphatic system may contribute to the comorbidities associated with visceral adipose tissue accumulation.</div> <div itemprodp="datePublished">Fri Jun 01 00:00:00 EDT 2018</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28191887"> <div itemprop="name">The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia.</div> </a> <div itemprop="about">Nature medicine</div> <div itemprop="author">Fenouille N,Bassil CF,Ben-Sahra I,Benajiba L,Alexe G,Ramos A,Pikman Y,Conway AS,Burgess MR,Li Q,Luciano F,Auberger P,Galinsky I,DeAngelo DJ,Stone RM,Zhang Y,Perkins AS,Shannon K,Hemann MT,Puissant A,Stegmaier K</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to investigate the effect of MECOM on cellular metabolism.</div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28953873"> <div itemprop="name">Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing.</div> </a> <div itemprop="about">Nature</div> <div itemprop="author">Camell CD,Sander J,Spadaro O,Lee A,Nguyen KY,Wing A,Goldberg EL,Youm YH,Brown CW,Elsworth J,Rodeheffer MS,Schultze JL,Dixit VD</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to show that adipose tissue macrophages regulate the age-related reduction in adipocyte lipolysis in mice by lowering the bioavailability of noradrenaline.</div> <div itemprodp="datePublished">Thu Oct 05 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29198913"> <div itemprop="name">Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment.</div> </a> <div itemprop="about">Cancer cell</div> <div itemprop="author">Turaj AH,Hussain K,Cox KL,Rose-Zerilli MJJ,Testa J,Dahal LN,Chan HTC,James S,Field VL,Carter MJ,Kim HJ,West JJ,Thomas LJ,He LZ,Keler T,Johnson PWM,Al-Shamkhani A,Thirdborough SM,Beers SA,Cragg MS,Glennie MJ,Lim SH</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to demonstrate the therapeutic advantage of using an immunomodulatory mAb to regulate lymphoid cells, which then recruit and activate myeloid cells for enhanced killing of mAb-opsonized tumors.</div> <div itemprodp="datePublished">Mon Dec 11 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29198913"> <div itemprop="name">Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment.</div> </a> <div itemprop="about">Cancer cell</div> <div itemprop="author">Turaj AH,Hussain K,Cox KL,Rose-Zerilli MJJ,Testa J,Dahal LN,Chan HTC,James S,Field VL,Carter MJ,Kim HJ,West JJ,Thomas LJ,He LZ,Keler T,Johnson PWM,Al-Shamkhani A,Thirdborough SM,Beers SA,Cragg MS,Glennie MJ,Lim SH</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to demonstrate the therapeutic advantage of using an immunomodulatory mAb to regulate lymphoid cells, which then recruit and activate myeloid cells for enhanced killing of mAb-opsonized tumors.</div> <div itemprodp="datePublished">Mon Dec 11 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28024152"> <div itemprop="name">Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.</div> </a> <div itemprop="about">Nature immunology</div> <div itemprop="author">Fang J,Bolanos LC,Choi K,Liu X,Christie S,Akunuru S,Kumar R,Wang D,Chen X,Greis KD,Stoilov P,Filippi MD,Maciejewski JP,Garcia-Manero G,Weirauch MT,Salomonis N,Geiger H,Zheng Y,Starczynowski DT</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to examine the significance of ubiquitin signalling in coordinating RNA processing by Toll-like receptor pathways during an immune response and in premalignant haematologic diseases.</div> <div itemprodp="datePublished">Wed Feb 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28218906"> <div itemprop="name">Differential cytokine contributions of perivascular haematopoietic stem cell niches.</div> </a> <div itemprop="about">Nature cell biology</div> <div itemprop="author">Asada N,Kunisaki Y,Pierce H,Wang Z,Fernandez NF,Birbrair A,Ma'ayan A,Frenette PS</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Mar 01 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28232470"> <div itemprop="name">Epithelial Fli1 deficiency drives systemic autoimmunity and fibrosis: Possible roles in scleroderma.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Takahashi T,Asano Y,Sugawara K,Yamashita T,Nakamura K,Saigusa R,Ichimura Y,Toyama T,Taniguchi T,Akamata K,Noda S,Yoshizaki A,Tsuruta D,Trojanowska M,Sato S</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Apr 03 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28188029"> <div itemprop="name">Peptidylarginine deiminase 2 is required for tumor necrosis factor alpha-induced citrullination and arthritis, but not neutrophil extracellular trap formation.</div> </a> <div itemprop="about">Journal of autoimmunity</div> <div itemprop="author">Bawadekar M,Shim D,Johnson CJ,Warner TF,Rebernick R,Damgaard D,Nielsen CH,Pruijn GJM,Nett JE,Shelef MA</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to identify the roles of peptidylarginine deiminase 2 and peptidylarginine deiminase 4 in citrullination, NETosis and arthritis.</div> <div itemprodp="datePublished">Thu Jun 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28762561"> <div itemprop="name">Diet-induced obesity causes visceral, but not subcutaneous, lymph node hyperplasia via increases in specific immune cell populations.</div> </a> <div itemprop="about">Cell proliferation</div> <div itemprop="author">Magnuson AM,Regan DP,Fouts JK,Booth AD,Dow SW,Foster MT</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to investigate whether secondary lymphatics within visceral adiposity contribute to disease risk.</div> <div itemprodp="datePublished">Sun Oct 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28747345"> <div itemprop="name">ORMDL3 Facilitates the Survival of Splenic B Cells via an ATF6α-Endoplasmic Reticulum Stress-Beclin1 Autophagy Regulatory Pathway.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Dang J,Bian X,Ma X,Li J,Long F,Shan S,Yuan Q,Xin Q,Li Y,Gao F,Gong Y,Liu Q</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to study the upregulation of orosomucoid-like 3 in both patients with systemic lupus erythematosus and lupus mice compared with controls.</div> <div itemprodp="datePublished">Fri Sep 01 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28615414"> <div itemprop="name">Loss of IP<sub>3</sub> Receptor-Mediated Ca<sup>2+</sup> Release in Mouse B Cells Results in Abnormal B Cell Development and Function.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Tang H,Wang H,Lin Q,Fan F,Zhang F,Peng X,Fang X,Liu J,Ouyang K</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to determine the function of 1,4,5-trisphosphate receptor-mediated Ca2+ release in B cells.</div> <div itemprodp="datePublished">Sat Jul 15 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27362366"> <div itemprop="name">ADAR1 deletion induces NFκB and interferon signaling dependent liver inflammation and fibrosis.</div> </a> <div itemprop="about">RNA biology</div> <div itemprop="author">Ben-Shoshan SO,Kagan P,Sultan M,Barabash Z,Dor C,Jacob-Hirsch J,Harmelin A,Pappo O,Marcu-Malina V,Ben-Ari Z,Amariglio N,Rechavi G,Goldstein I,Safran M</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to study the regulatory role of ADAR1 in hepatic immune homeostasis.</div> <div itemprodp="datePublished">Thu May 04 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28713327"> <div itemprop="name">IL-2/Anti-IL-2 Complex Attenuates Inflammation and BBB Disruption in Mice Subjected to Traumatic Brain Injury.</div> </a> <div itemprop="about">Frontiers in neurology</div> <div itemprop="author">Gao W,Li F,Zhou Z,Xu X,Wu Y,Zhou S,Yin D,Sun D,Xiong J,Jiang R,Zhang J</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to suggest that IL-2C treatment can alleviate inflammation and maintain blood vessel stability after traumatic brain injury.</div> <div itemprodp="datePublished">Thu Oct 01 00:00:00 EDT 2020</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29026085"> <div itemprop="name">EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Béguelin W,Rivas MA,Calvo Fernández MT,Teater M,Purwada A,Redmond D,Shen H,Challman MF,Elemento O,Singh A,Melnick AM</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Oct 12 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29044097"> <div itemprop="name">DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Ottina E,Peperzak V,Schoeler K,Carrington E,Sgonc R,Pellegrini M,Preston S,Herold MJ,Strasser A,Villunger A</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Oct 18 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28405519"> <div itemprop="name">The Interleukin (IL)-1R1 pathway is a critical negative regulator of PyMT-mediated mammary tumorigenesis and pulmonary metastasis.</div> </a> <div itemprop="about">Oncoimmunology</div> <div itemprop="author">Dagenais M,Dupaul-Chicoine J,Douglas T,Champagne C,Morizot A,Saleh M</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Jan 12 00:00:00 EST 2021</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28814662"> <div itemprop="name">Irgm1 coordinately regulates autoimmunity and host defense at select mucosal surfaces.</div> </a> <div itemprop="about">JCI insight</div> <div itemprop="author">Azzam KM,Madenspacher JH,Cain DW,Lai L,Gowdy KM,Rai P,Janardhan K,Clayton N,Cunningham W,Jensen H,Patel PS,Kearney JF,Taylor GA,Fessler MB</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Aug 17 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28235052"> <div itemprop="name">Multiple functional therapeutic effects of TnP: A small stable synthetic peptide derived from fish venom in a mouse model of multiple sclerosis.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Komegae EN,Souza TA,Grund LZ,Lima C,Lopes-Ferreira M</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Aug 17 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/29312584"> <div itemprop="name">Recipient bone marrow assimilates the myeloid/lymphoid reconstitution of distinct fetal hematopoietic stem cells.</div> </a> <div itemprop="about">Oncotarget</div> <div itemprop="author">Guo XL,Chu L,Ke F,Mu LL,Li Z,Cai JJ,Li HF,Hong DL</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to show that the recipient bone marrow microenvironment could determine the developmental lineage-trends of fetal liver hematopoietic stem and progenitor cells.</div> <div itemprodp="datePublished">Tue Dec 12 00:00:00 EST 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27863245"> <div itemprop="name">Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells.</div> </a> <div itemprop="about">Cell</div> <div itemprop="author">Yu VWC,Yusuf RZ,Oki T,Wu J,Saez B,Wang X,Cook C,Baryawno N,Ziller MJ,Lee E,Gu H,Meissner A,Lin CP,Kharchenko PV,Scadden DT</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to define the extent of, and molecular basis for, haematopoetic stem cell heterogeneity using a multi-fluorescent mouse model.</div> <div itemprodp="datePublished">Thu Nov 17 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27810923"> <div itemprop="name">Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Zamora-Pineda J,Kumar A,Suh JH,Zhang M,Saba JD</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to investigate the role of dendritic cell sphingosine-1-phosphate lyase in thymic egress.</div> <div itemprodp="datePublished">Mon Nov 14 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27417580"> <div itemprop="name">Monocyte Adhesion and Plaque Recruitment During Atherosclerosis Development Is Regulated by the Adapter Protein Chat-H/SHEP1.</div> </a> <div itemprop="about">Arteriosclerosis, thrombosis, and vascular biology</div> <div itemprop="author">Herbin O,Regelmann AG,Ramkhelawon B,Weinstein EG,Moore KJ,Alexandropoulos K</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to analyse the role of Chat-H in atherosclerosis development, showing that monocyte adhesion and plaque recruitment is regulated by Chat-H/SHEP1.</div> <div itemprodp="datePublished">Thu Sep 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27245614"> <div itemprop="name">The 4E-BP-eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes.</div> </a> <div itemprop="about">Science signaling</div> <div itemprop="author">So L,Lee J,Palafox M,Mallya S,Woxland CG,Arguello M,Truitt ML,Sonenberg N,Ruggero D,Fruman DA</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to investigate the mechanism by which rapamycin leads to selective immunosupression of lymphocytes, showing that the 4E-BP-efF4E axis promotes growth and proliferation of lymphocytes and is uniquely sensitive to rapamycin in these cells.</div> <div itemprodp="datePublished">Tue May 31 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28066432"> <div itemprop="name">CD4 T Helper Cells Instruct Lymphopenia-Induced Memory-Like CD8 T Cells for Control of Acute LCMV Infection.</div> </a> <div itemprop="about">Frontiers in immunology</div> <div itemprop="author">Schmitt ME,Sitte S,Voehringer D</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to determine whether memory-like T cells can efficiently respond to foreign antigen and participate in antiviral immunity.</div> <div itemprodp="datePublished">Wed Nov 20 00:00:00 EST 2019</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26362817"> <div itemprop="name">Adipose tissue adaptive response to trans-10,cis-12-conjugated linoleic acid engages alternatively activated M2 macrophages.</div> </a> <div itemprop="about">FASEB journal : official publication of the Federation of American Societies for Experimental Biology</div> <div itemprop="author">Pini M,Touch S,Poirier H,Dalmas E,Niot I,Rouault C,Druart C,Delzenne N,Clément K,André S,Guerre-Millo M</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to reveal a striking resilience of white adipose tissue after a short-term metabolic injury induced by t10,c12-CLA, which relies on alternatively activated M2 macrophage engagement.</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27357149"> <div itemprop="name">Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Menendez CM,Jinkins JK,Carr DJ</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Aug 15 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26582949"> <div itemprop="name">Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Skeldon AM,Morizot A,Douglas T,Santoro N,Kursawe R,Kozlitina J,Caprio S,Mehal WZ,Saleh M</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to investigate a role for caspase-11 and caspase-12 in obesity and insulin resistance.</div> <div itemprodp="datePublished">Fri Jan 01 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26895837"> <div itemprop="name">Type I IFN Does Not Promote Susceptibility to Foodborne Listeria monocytogenes.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Pitts MG,Myers-Morales T,D'Orazio SE</div> <div itemprop="description">17-0452 was used in an ELISA assay to investigate whether type I IFN promotes susceptibility to foodborne Listeria monocytogenes.</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26895837"> <div itemprop="name">Type I IFN Does Not Promote Susceptibility to Foodborne Listeria monocytogenes.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Pitts MG,Myers-Morales T,D'Orazio SE</div> <div itemprop="description">17-0452 was used in an ELISA assay to investigate whether type I IFN promotes susceptibility to foodborne Listeria monocytogenes.</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27506447"> <div itemprop="name">Transcriptional regulation of the proto-oncogene Zfp521 by SPI1 (PU.1) and HOXC13.</div> </a> <div itemprop="about">Genesis (New York, N.Y. : 2000)</div> <div itemprop="author">Yu M,Al-Dallal S,Al-Haj L,Panjwani S,McCartney AS,Edwards SM,Manjunath P,Walker C,Awgulewitsch A,Hentges KE</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to study the regulatory factors controlling the mouse zinc-finger gene Zfp521; a B-cell proto-oncogene.</div> <div itemprodp="datePublished">Sat Oct 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27453007"> <div itemprop="name">Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.</div> </a> <div itemprop="about">Stem cell reports</div> <div itemprop="author">Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Aug 09 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27658009"> <div itemprop="name">Sequencing and cloning of antigen-specific antibodies from mouse memory B cells.</div> </a> <div itemprop="about">Nature protocols</div> <div itemprop="author">von Boehmer L,Liu C,Ackerman S,Gitlin AD,Wang Q,Gazumyan A,Nussenzweig MC</div> <div itemprop="description">17-0452-82 was used in Flow cytometry/Cell sorting to sequence and clone the variable antibody region of single antigen-specific mouse memory B cells for antibody production.</div> <div itemprodp="datePublished">Sat Oct 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27471636"> <div itemprop="name">CXCL16-positive dendritic cells enhance invariant natural killer T cell-dependent IFNγ production and tumor control.</div> </a> <div itemprop="about">Oncoimmunology</div> <div itemprop="author">Veinotte L,Gebremeskel S,Johnston B</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to study the co-stimulatory role of CXCR6/CXCL16 interactions in glycolipid-dependent invariant natural killer T (iNKT) cell activation and tumour control, showing that CXCL16-positive dendritic cells enhance iNKT cell-dependent IFNγ production and tumor control.</div> <div itemprodp="datePublished">Wed Jun 01 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27116251"> <div itemprop="name">miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Jiang X,Hu C,Arnovitz S,Bugno J,Yu M,Zuo Z,Chen P,Huang H,Ulrich B,Gurbuxani S,Weng H,Strong J,Wang Y,Li Y,Salat J,Li S,Elkahloun AG,Yang Y,Neilly MB,Larson RA,Le Beau MM,Herold T,Bohlander SK,Liu PP,Zhang J,Li Z,He C,Jin J,Hong S,Chen J</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to investigate the anti-tumourigenic role of miR-22, showing that it has an anti-tumour role in acute myeloid leukaemia.</div> <div itemprodp="datePublished">Tue Apr 26 00:00:00 EDT 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27428079"> <div itemprop="name">Alkylator-Induced and Patient-Derived Xenograft Mouse Models of Therapy-Related Myeloid Neoplasms Model Clinical Disease and Suggest the Presence of Multiple Cell Subpopulations with Leukemia Stem Cell Activity.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Jonas BA,Johnson C,Gratzinger D,Majeti R</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to report several new t-AML/MDS mouse models that could potentially be used to further define disease pathogenesis and test novel therapeutics.</div> <div itemprodp="datePublished">Wed Jul 26 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/27869129"> <div itemprop="name">Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Cheng H,Ang HY,A El Farran C,Li P,Fang HT,Liu TM,Kong SL,Chin ML,Ling WY,Lim EK,Li H,Huber T,Loh KM,Loh YH,Lim B</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to demonstrate how it is possible to reprogram mouse embryonic fibroblasts into engraftable blood progenitors.</div> <div itemprodp="datePublished">Mon Nov 21 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/28033400"> <div itemprop="name">Heme Oxygenase-1-Expressing Dendritic Cells Promote Foxp3+ Regulatory T Cell Differentiation and Induce Less Severe Airway Inflammation in Murine Models.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Wong TH,Chen HA,Gau RJ,Yen JH,Suen JL</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to study the role of heme oxygenase-1 in dendritic cell-mediated T cell differentiation.</div> <div itemprodp="datePublished">Mon Jul 10 00:00:00 EDT 2017</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25565205"> <div itemprop="name">Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability.</div> </a> <div itemprop="about">Cell metabolism</div> <div itemprop="author">Lodhi IJ,Wei X,Yin L,Feng C,Adak S,Abou-Ezzi G,Hsu FF,Link DC,Semenkovich CF</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to investigate the immunometabolism pathway by which peroxisomal lipid synthesis regulates neutrophil development and inflammation.</div> <div itemprodp="datePublished">Tue Jan 06 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26551682"> <div itemprop="name">Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Henry CJ,Casás-Selves M,Kim J,Zaberezhnyy V,Aghili L,Daniel AE,Jimenez L,Azam T,McNamee EN,Clambey ET,Klawitter J,Serkova NJ,Tan AC,Dinarello CA,DeGregori J</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Dec 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26075824"> <div itemprop="name">Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1.</div> </a> <div itemprop="about">The Journal of clinical investigation</div> <div itemprop="author">Fond AM,Lee CS,Schulman IG,Kiss RS,Ravichandran KS</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to identify a membrane-initiated pathway that is triggered by apoptotic cells to enhance ABCA1 within engulfing phagocytes.</div> <div itemprodp="datePublished">Wed Jul 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25987726"> <div itemprop="name">BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Jacque E,Schweighoffer E,Tybulewicz VL,Ley SC</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to reveal a potentially critical role for the MEK5-ERK5 MAP kinase signalling pathway in BAFF-induced mature B cell survival and homeostatic maintenance of B2 cell numbers.</div> <div itemprodp="datePublished">Mon Jun 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25556169"> <div itemprop="name">Tamm-Horsfall Protein Regulates Granulopoiesis and Systemic Neutrophil Homeostasis.</div> </a> <div itemprop="about">Journal of the American Society of Nephrology : JASN</div> <div itemprop="author">Micanovic R,Chitteti BR,Dagher PC,Srour EF,Khan S,Hato T,Lyle A,Tong Y,Wu XR,El-Achkar TM</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to show that Tamm-Horsfall protein deficiency in mice causes systemic neutrophilia through enhanced granulopoiesis in the bone marrow.</div> <div itemprodp="datePublished">Tue Sep 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26460037"> <div itemprop="name">Bcl6 middle domain repressor function is required for T follicular helper cell differentiation and utilizes the corepressor MTA3.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Nance JP,Bélanger S,Johnston RJ,Hu JK,Takemori T,Crotty S</div> <div itemprop="description">17-0452 was used in Immunohistochemistry to discover that Bcl6 middle domain mediated repression is important for control of CD4 T-cell fate and function.</div> <div itemprodp="datePublished">Tue Oct 27 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25613378"> <div itemprop="name">Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.</div> </a> <div itemprop="about">Cell death and differentiation</div> <div itemprop="author">Cho J,Seo J,Lim CH,Yang L,Shiratsuchi T,Lee MH,Chowdhury RR,Kasahara H,Kim JS,Oh SP,Lee YJ,Terada N</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Sep 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25429072"> <div itemprop="name">Natural IgM is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Reynolds AE,Kuraoka M,Kelsoe G</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to investigate the origin of natural IgM, showing that it is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow.</div> <div itemprodp="datePublished">Thu Jan 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25694612"> <div itemprop="name">Core fucosylation of IgG B cell receptor is required for antigen recognition and antibody production.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Li W,Yu R,Ma B,Yang Y,Jiao X,Liu Y,Cao H,Dong W,Liu L,Ma K,Fukuda T,Liu Q,Ma T,Wang Z,Gu J,Zhang J,Taniguchi N</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to investigate core fucosylation of IgG B cell receptor's role in antigen recognition and antibody production.</div> <div itemprodp="datePublished">Sun Mar 15 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25429069"> <div itemprop="name">MHC-mismatched mixed chimerism mediates thymic deletion of cross-reactive autoreactive T cells and prevents insulitis in nonobese diabetic mice.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Racine JJ,Zhang M,Wang M,Morales W,Shen C,Zeng D</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to investigate whether mismatched MHC class II in mixed chimeras mediates deletion of cross-reactive autoreactive thymocytes.</div> <div itemprodp="datePublished">Thu Jan 01 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26216893"> <div itemprop="name">The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Douglas T,Champagne C,Morizot A,Lapointe JM,Saleh M</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to implicate the inflammasome as an important initiating signal in skin disease pathogenesis.</div> <div itemprodp="datePublished">Tue Sep 01 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26617239"> <div itemprop="name">Endothelial Gata5 transcription factor regulates blood pressure.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Messaoudi S,He Y,Gutsol A,Wight A,Hébert RL,Vilmundarson RO,Makrigiannis AP,Chalmers J,Hamet P,Tremblay J,McPherson R,Stewart AFR,Touyz RM,Nemer M</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Nov 30 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/26104863"> <div itemprop="name">Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Singh NK,Kotla S,Dyukova E,Traylor JG,Orr AW,Chernoff J,Marion TN,Rao GN</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Jun 24 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25695838"> <div itemprop="name">TGF-β3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses.</div> </a> <div itemprop="about">Nature communications</div> <div itemprop="author">Okamura T,Sumitomo S,Morita K,Iwasaki Y,Inoue M,Nakachi S,Komai T,Shoda H,Miyazaki J,Fujio K,Yamamoto K</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to investigate the role of GF-β3-expressing CD4+CD25(-)LAG3+ Tregs in humoral immune responses.</div> <div itemprodp="datePublished">Thu Feb 19 00:00:00 EST 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25793392"> <div itemprop="name">Standard sub-thermoneutral caging temperature influences radiosensitivity of hematopoietic stem and progenitor cells.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Povinelli BJ,Kokolus KM,Eng JW,Dougher CW,Curtin L,Capitano ML,Sailsbury-Ruf CT,Repasky EA,Nemeth MJ</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to demonstrate that chronic stress of laboratory mice increases the resistance of hematopoietic stem and progenitor cells to irradiation-induced apoptosis.</div> <div itemprodp="datePublished">Tue Feb 09 00:00:00 EST 2016</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24657994"> <div itemprop="name">CD4+ T cells promote the transition from hypertrophy to heart failure during chronic pressure overload.</div> </a> <div itemprop="about">Circulation</div> <div itemprop="author">Laroumanie F,Douin-Echinard V,Pozzo J,Lairez O,Tortosa F,Vinel C,Delage C,Calise D,Dutaur M,Parini A,Pizzinat N</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to investigate the involvement of T cells in the progression to heart failure using a transverse aortic constriction (TAC) model.</div> <div itemprodp="datePublished">Tue May 27 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25224412"> <div itemprop="name">α-1-Antitrypsin (AAT)-modified donor cells suppress GVHD but enhance the GVL effect: a role for mitochondrial bioenergetics.</div> </a> <div itemprop="about">Blood</div> <div itemprop="author">Marcondes AM,Karoopongse E,Lesnikova M,Margineantu D,Welte T,Dinarello CA,Hockenbery D,Janciauskiene S,Deeg HJ</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to investigate the role of α-1-antitrypsin in graft-versus-host disease, showing that α-1-Antitrypsin-modified donor cells suppress graft-versus-host disease but enhance the graft-versus-leukemia effect.</div> <div itemprodp="datePublished">Thu Oct 30 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24497204"> <div itemprop="name">Peptidylarginine deiminase 4 contributes to tumor necrosis factor α-induced inflammatory arthritis.</div> </a> <div itemprop="about">Arthritis & rheumatology (Hoboken, N.J.)</div> <div itemprop="author">Shelef MA,Sokolove J,Lahey LJ,Wagner CA,Sackmann EK,Warner TF,Wang Y,Beebe DJ,Robinson WH,Huttenlocher A</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to investigate whether TNFα and PAD4 may synergistically exacerbate autoantibody production and inflammatory arthritis, showing that PAD4 contributes to TNFα-induced inflammatory arthritis.</div> <div itemprodp="datePublished">Sun Jun 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25161889"> <div itemprop="name">Diet-induced obesity promotes myelopoiesis in hematopoietic stem cells.</div> </a> <div itemprop="about">Molecular metabolism</div> <div itemprop="author">Singer K,DelProposto J,Morris DL,Zamarron B,Mergian T,Maley N,Cho KW,Geletka L,Subbaiah P,Muir L,Martinez-Santibanez G,Lumeng CN</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to demonstrate how metabolic signals potentiate leukocyte production and dietary priming of haematopoietic progenitors contributes to adipose tissue inflammation.</div> <div itemprodp="datePublished">Mon Sep 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24610714"> <div itemprop="name">CD41 is a reliable identification and activation marker for murine basophils in the steady state and during helminth and malarial infections.</div> </a> <div itemprop="about">European journal of immunology</div> <div itemprop="author">Bakocevic N,Claser C,Yoshikawa S,Jones LA,Chew S,Goh CC,Malleret B,Larbi A,Ginhoux F,de Lafaille MC,Karasuyama H,Renia L,Ng LG</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to study the CD41 expression within basophils from the blood during both steady state and malarial inections within mice.</div> <div itemprodp="datePublished">Sun Jun 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25238757"> <div itemprop="name">Transcription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein response.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Park KS,Bayles I,Szlachta-McGinn A,Paul J,Boiko J,Santos P,Liu J,Wang Z,Borghesi L,Milcarek C</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Nov 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24591377"> <div itemprop="name">IκBε is a key regulator of B cell expansion by providing negative feedback on cRel and RelA in a stimulus-specific manner.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Alves BN,Tsui R,Almaden J,Shokhirev MN,Davis-Turak J,Fujimoto J,Birnbaum H,Ponomarenko J,Hoffmann A</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Apr 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24616476"> <div itemprop="name">Eosinophils regulate peripheral B cell numbers in both mice and humans.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Wong TW,Doyle AD,Lee JJ,Jelinek DF</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to assess the effect of eosinophils on B cell survival, proliferation, and Ig secretion.</div> <div itemprodp="datePublished">Tue Apr 15 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24534531"> <div itemprop="name">A TNF-α-CCL20-CCR6 axis regulates Nod1-induced B cell responses.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Paradis M,Mindt BC,Duerr CU,Rojas OL,Ng D,Boulianne B,McCarthy DD,Yu MD,Summers deLuca LE,Ward LA,Waldron JB,Philpott DJ,Gommerman JL,Fritz JH</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to reveal a novel mechanism of B cells during inflammation and shed light on how B cells participate in innate immune responses to microbial stimulation.</div> <div itemprodp="datePublished">Sat Mar 15 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24591371"> <div itemprop="name">Relapsing-remitting central nervous system autoimmunity mediated by GFAP-specific CD8 T cells.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Sasaki K,Bean A,Shah S,Schutten E,Huseby PG,Peters B,Shen ZT,Vanguri V,Liggitt D,Huseby ES</div> <div itemprop="description">17-0452 was used in Immunohistochemistry to investigate the mechanism by which CD8 T cells mediate relapsing-remitting inflammatory CNS autoimmunity.</div> <div itemprodp="datePublished">Tue Apr 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24170780"> <div itemprop="name">TRAF6 is a critical regulator of LMP1 functions in vivo.</div> </a> <div itemprop="about">International immunology</div> <div itemprop="author">Arcipowski KM,Stunz LL,Bishop GA</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to investigate TRAF6 as a critical regulator of LMP1 versus CD40 specific B-cell functions in TRAF6-deficient mice.</div> <div itemprodp="datePublished">Sat Mar 01 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25741038"> <div itemprop="name">Rhof promotes murine marginal zone B cell development.</div> </a> <div itemprop="about">Nagoya journal of medical science</div> <div itemprop="author">Kishimoto M,Matsuda T,Yanase S,Katsumi A,Suzuki N,Ikejiri M,Takagi A,Ikawa M,Kojima T,Kunishima S,Kiyoi H,Naoe T,Matsushita T,Maruyama M</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Aug 01 00:00:00 EDT 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24651473"> <div itemprop="name">B-cell-intrinsic hepatitis C virus expression leads to B-cell-lymphomagenesis and induction of NF-κB signalling.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Kasama Y,Mizukami T,Kusunoki H,Peveling-Oberhag J,Nishito Y,Ozawa M,Kohara M,Mizuochi T,Tsukiyama-Kohara K</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Dec 22 00:00:00 EST 2014</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/25296026"> <div itemprop="name">Self DNA from lymphocytes that have undergone activation-induced cell death enhances murine B cell proliferation and antibody production.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Lu Q,Wang JY,Wang L,Jiang X,Chu Y</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to study how self DNA can act as a damage-associated molecular pattern which promotes B cell activation and differentiation in autoimmune disease.</div> <div itemprodp="datePublished">Wed Jun 24 00:00:00 EDT 2015</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23580663"> <div itemprop="name">Long-term prevention of chronic allograft rejection by regulatory T-cell immunotherapy involves host Foxp3-expressing T cells.</div> </a> <div itemprop="about">Blood</div> <div itemprop="author">Pasquet L,Douet JY,Sparwasser T,Romagnoli P,van Meerwijk JP</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to assess if persistence of administered regulatory T cells is required for long-term maintenance of tolerance to allografts.</div> <div itemprodp="datePublished">Thu May 23 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24323356"> <div itemprop="name">MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Molnarfi N,Schulze-Topphoff U,Weber MS,Patarroyo JC,Prod'homme T,Varrin-Doyer M,Shetty A,Linington C,Slavin AJ,Hidalgo J,Jenne DE,Wekerle H,Sobel RA,Bernard CC,Shlomchik MJ,Zamvil SS</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to investigate the contribution of B cells to antigen presentation and pathogenic T cell activation in the multiple sclerosis model experimental autoimmune encephalomyelitis.</div> <div itemprodp="datePublished">Mon Dec 16 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24145513"> <div itemprop="name">A type I IFN-Flt3 ligand axis augments plasmacytoid dendritic cell development from common lymphoid progenitors.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Chen YL,Chen TT,Pai LM,Wesoly J,Bluyssen HA,Lee CK</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to define a critical role for the FL/IFN-I/Flt3 axis in plasmacytoid dendritic cell differentiation from common lymphoid progenitors.</div> <div itemprodp="datePublished">Mon Nov 18 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24014378"> <div itemprop="name">VBP15, a novel anti-inflammatory and membrane-stabilizer, improves muscular dystrophy without side effects.</div> </a> <div itemprop="about">EMBO molecular medicine</div> <div itemprop="author">Heier CR,Damsker JM,Yu Q,Dillingham BC,Huynh T,Van der Meulen JH,Sali A,Miller BK,Phadke A,Scheffer L,Quinn J,Tatem K,Jordan S,Dadgar S,Rodriguez OC,Albanese C,Calhoun M,Gordish-Dressman H,Jaiswal JK,Connor EM,McCall JM,Hoffman EP,Reeves EK,Nagaraju K</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to demonstrate successful improvement of dystrophy independent of hormonal, growth, or immunosuppressive effects, indicating VBP15 merits clinical investigation for Duchenne muscular dystrophy.</div> <div itemprodp="datePublished">Tue Oct 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23615463"> <div itemprop="name">Reciprocal effects of rab7 deletion in activated and neglected T cells.</div> </a> <div itemprop="about">Autophagy</div> <div itemprop="author">Roy SG,Stevens MW,So L,Edinger AL</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Mon Jul 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23423360"> <div itemprop="name">Lipidoid Nanoparticles Containing PD-L1 siRNA Delivered In Vivo Enter Kupffer Cells and Enhance NK and CD8(+) T Cell-mediated Hepatic Antiviral Immunity.</div> </a> <div itemprop="about">Molecular therapy. Nucleic acids</div> <div itemprop="author">Dolina JS,Sung SS,Novobrantseva TI,Nguyen TM,Hahn YS</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to demonstrate that PD-L1 knockdown on KCs is central in determining the outcome of liver viral infections, and they represent a new class of gene therapy.</div> <div itemprodp="datePublished">Tue Feb 19 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24292417"> <div itemprop="name">(18)F-FDG-PET/CT imaging in an IL-6- and MYC-driven mouse model of human multiple myeloma affords objective evaluation of plasma cell tumor progression and therapeutic response to the proteasome inhibitor ixazomib.</div> </a> <div itemprop="about">Blood cancer journal</div> <div itemprop="author">Duncan K,Rosean TR,Tompkins VS,Olivier A,Sompallae R,Zhan F,Tricot G,Acevedo MR,Ponto LL,Walsh SA,Tygrett LT,Berger AJ,Waldschmidt T,Morse HC,Sunderland JJ,Janz S</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to demonstrate the utility of (18)F-fluorodeoxyglucose positron emission tomography and computed tomography for assessing IL-6 and MYC-driven plasma cell tumour development.</div> <div itemprodp="datePublished">Fri Nov 29 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24068938"> <div itemprop="name">Genome-wide mouse mutagenesis reveals CD45-mediated T cell function as critical in protective immunity to HSV-1.</div> </a> <div itemprop="about">PLoS pathogens</div> <div itemprop="author">Caignard G,Leiva-Torres GA,Leney-Greene M,Charbonneau B,Dumaine A,Fodil-Cornu N,Pyzik M,Cingolani P,Schwartzentruber J,Dupaul-Chicoine J,Guo H,Saleh M,Veillette A,Lathrop M,Blanchette M,Majewski J,Pearson A,Vidal SM</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to identify host factors involved in HSV-1 and herpes simplex encephalitis susceptibility in an in vivo HSV-1 infectious model.</div> <div itemprodp="datePublished">Sun Sep 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23505065"> <div itemprop="name">Cellular-FLIP, Raji isoform (c-FLIP R) modulates cell death induction upon T-cell activation and infection.</div> </a> <div itemprop="about">European journal of immunology</div> <div itemprop="author">Telieps T,Ewald F,Gereke M,Annemann M,Rauter Y,Schuster M,Ueffing N,von Smolinski D,Gruber AD,Bruder D,Schmitz I</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to study the induction of endogenous murine cellular-FLIPR in activated lymphocytes.</div> <div itemprodp="datePublished">Sat Jun 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23255789"> <div itemprop="name">Antioxidant treatment regulates the humoral immune response during acute viral infection.</div> </a> <div itemprop="about">Journal of virology</div> <div itemprop="author">Crump KE,Langston PK,Rajkarnikar S,Grayson JM</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to show that antioxidant treatment regulates the humoral immune response during acute viral infection.</div> <div itemprodp="datePublished">Fri Mar 01 00:00:00 EST 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23554255"> <div itemprop="name">Arrayed lentiviral barcoding for quantification analysis of hematopoietic dynamics.</div> </a> <div itemprop="about">Stem cells (Dayton, Ohio)</div> <div itemprop="author">Grosselin J,Sii-Felice K,Payen E,Chretien S,Tronik-Le Roux D,Leboulch P</div> <div itemprop="description">17-0452-82 was used in Flow Cytometry to demonstrate arrayed lentiviral barcoding as a versatile and powerful approach to deconvolute cell dynamics in vivo with applications in hematology, embryology, and cancer biology.</div> <div itemprodp="datePublished">Tue Oct 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23709681"> <div itemprop="name">Thymic damage, impaired negative selection, and development of chronic graft-versus-host disease caused by donor CD4+ and CD8+ T cells.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Wu T,Young JS,Johnston H,Ni X,Deng R,Racine J,Wang M,Wang A,Todorov I,Wang J,Zeng D</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to evaluate the contribution of T cells to the induction of chronic graft-versus-host disease.</div> <div itemprodp="datePublished">Mon Jul 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24068672"> <div itemprop="name">AID-expressing germinal center B cells cluster normally within lymph node follicles in the absence of FDC-M1+ CD35+ follicular dendritic cells but dissipate prematurely.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Boulianne B,Le MX,Ward LA,Meng L,Haddad D,Li C,Martin A,Gommerman JL</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to provide a spatial-temporal analysis of Ag-specific B cell activation and AID expression in the context of a peripheral lymph node that lacks FDC-M1(+) CD35(+) FDC and other LT-sensitive cell types.</div> <div itemprodp="datePublished">Fri Nov 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23918785"> <div itemprop="name">CD30 is required for activation of a unique subset of interleukin-17A-producing γδ T cells in innate immunity against Mycobacterium bovis Bacillus Calmette-Guerin infection.</div> </a> <div itemprop="about">Infection and immunity</div> <div itemprop="author">Guo Y,Sun X,Shibata K,Yamada H,Muta H,Podack ER,Yoshikai Y</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to demonstrate the involvement of CD30 signalling in the production of IL-17A by γδ T cells following BCG infection.</div> <div itemprodp="datePublished">Tue Oct 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23340311"> <div itemprop="name">Myeloid dendritic cells (DCs) of mice susceptible to paracoccidioidomycosis suppress T cell responses whereas myeloid and plasmacytoid DCs from resistant mice induce effector and regulatory T cells.</div> </a> <div itemprop="about">Infection and immunity</div> <div itemprop="author">Pina A,de Araujo EF,Felonato M,Loures FV,Feriotti C,Bernardino S,Barbuto JA,Calich VL</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to highlight the deleterious effect of excessive innate proinflammatory reaction and provide new evidence for the importance of immunomodulation during pulmonary paracoccidioidomycosis.</div> <div itemprodp="datePublished">Mon Apr 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23749724"> <div itemprop="name">Neuronal and nonneuronal cholinergic structures in the mouse gastrointestinal tract and spleen.</div> </a> <div itemprop="about">The Journal of comparative neurology</div> <div itemprop="author">Gautron L,Rutkowski JM,Burton MD,Wei W,Wan Y,Elmquist JK</div> <div itemprop="description">17-0452-82 was used in Immunohistochemistry to describe a variety of cholinergic neuronal and non-neuronal cells that modulate gastrointestinal and splenic immunity.</div> <div itemprodp="datePublished">Fri Nov 01 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23505375"> <div itemprop="name">TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo.</div> </a> <div itemprop="about">PLoS genetics</div> <div itemprop="author">Gómez-Herreros F,Romero-Granados R,Zeng Z,Alvarez-Quilón A,Quintero C,Ju L,Umans L,Vermeire L,Huylebroeck D,Caldecott KW,Cortés-Ledesma F</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu Jun 13 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22251480"> <div itemprop="name">Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML.</div> </a> <div itemprop="about">Blood</div> <div itemprop="author">Li Z,Huang H,Li Y,Jiang X,Chen P,Arnovitz S,Radmacher MD,Maharry K,Elkahloun A,Yang X,He C,He M,Zhang Z,Dohner K,Neilly MB,Price C,Lussier YA,Zhang Y,Larson RA,Le Beau MM,Caligiuri MA,Bullinger L,Valk PJ,Delwel R,Lowenberg B,Liu PP,Marcucci G,Bloomfield CD,Rowley JD,Chen J</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to study the prognostic impact of the four members of the miR-181 family in patients with CA-AML.</div> <div itemprodp="datePublished">Thu Mar 08 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22927250"> <div itemprop="name">Biphenotypic B-lymphoid/myeloid cells expressing low levels of Pax5: potential targets of BAL development.</div> </a> <div itemprop="about">Blood</div> <div itemprop="author">Simmons S,Knoll M,Drewell C,Wolf I,Mollenkopf HJ,Bouquet C,Melchers F</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to investigate how variation in Pax5 expression influences hematopoietic development, showing that biphenotypic B-lymphoid/myeloid cells expressing low levels of Pax5 could be targets for BAL.</div> <div itemprodp="datePublished">Thu Nov 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22544702"> <div itemprop="name">IKKα-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis.</div> </a> <div itemprop="about">Blood</div> <div itemprop="author">Balkhi MY,Willette-Brown J,Zhu F,Chen Z,Liu S,Guttridge DC,Karin M,Hu Y</div> <div itemprop="description">17-0452-82 was used in Flow Cytometry to demonstrate that IKKα regulates B-lineage commitment via combined canonical and noncanonical NF-κB transcriptional activities to target Pax5 expression during hematopoiesis.</div> <div itemprodp="datePublished">Thu Jun 07 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21997806"> <div itemprop="name">Mechanisms of indirect acute lung injury: a novel role for the coinhibitory receptor, programmed death-1.</div> </a> <div itemprop="about">Annals of surgery</div> <div itemprop="author">Monaghan SF,Thakkar RK,Heffernan DS,Huang X,Chung CS,Lomas-Neira J,Cioffi WG,Ayala A</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to investigate how PD-1 expression contributes to mortality after the induction of indirect-acute lung injury.</div> <div itemprodp="datePublished">Sun Jan 01 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22643865"> <div itemprop="name">MyD88 signaling in B cells regulates the production of Th1-dependent antibodies to AAV.</div> </a> <div itemprop="about">Molecular therapy : the journal of the American Society of Gene Therapy</div> <div itemprop="author">Sudres M,Ciré S,Vasseur V,Brault L,Da Rocha S,Boisgérault F,Le Bec C,Gross DA,Blouin V,Ryffel B,Galy A</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to discover that MyD88 signalling in B cells, but not T cells, was sufficient to produce Th1-dependent IgGs.</div> <div itemprodp="datePublished">Wed Aug 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23087406"> <div itemprop="name">Critical role of B cell lymphoma 10 in BAFF-regulated NF-κB activation and survival of anergic B cells.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Yu M,Chen Y,He Y,Podd A,Fu G,Wright JA,Kleiman E,Khan WN,Wen R,Wang D</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Dec 01 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22826323"> <div itemprop="name">Activation-induced cytidine deaminase-initiated off-target DNA breaks are detected and resolved during S phase.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Hasham MG,Snow KJ,Donghia NM,Branca JA,Lessard MD,Stavnezer J,Shopland LS,Mills KD</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Sep 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23109728"> <div itemprop="name">TRAF binding is required for a distinct subset of in vivo B cell functions of the oncoprotein LMP1.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Arcipowski KM,Bishop GA</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to investigate whether the mechanism of action of TRAF proteins for LMP1 in vivo functions requires direct association.</div> <div itemprodp="datePublished">Sat Dec 01 00:00:00 EST 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23166752"> <div itemprop="name">Th17 effector cells support B cell responses outside of germinal centres.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Patakas A,Benson RA,Withers DR,Conigliaro P,McInnes IB,Brewer JM,Garside P</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to investigate the role of Th17 cells in the development of a humoral immune response using T and B cell receptor transgenic mice.</div> <div itemprodp="datePublished">Thu Jun 20 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/24672679"> <div itemprop="name">Impact of enzymatic tissue disintegration on the level of surface molecule expression and immune cell function.</div> </a> <div itemprop="about">European journal of microbiology & immunology</div> <div itemprop="author">Autengruber A,Gereke M,Hansen G,Hennig C,Bruder D</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to indicate that enzymatic tissue disintegration can have profound effects on the expression of a variety of cell-surface molecules.</div> <div itemprodp="datePublished">Fri Jun 01 00:00:00 EDT 2012</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/23071588"> <div itemprop="name">Induction of IL-10-producing CD1dhighCD5+ regulatory B cells following Babesia microti-infection.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Jeong YI,Hong SH,Cho SH,Lee WJ,Lee SE</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to demonstrate the expansion of Bregs following infection by an intraerythrocytic protozoan parasite.</div> <div itemprodp="datePublished">Tue Apr 02 00:00:00 EDT 2013</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21333553"> <div itemprop="name">Nuclear export of the NF-κB inhibitor IκBα is required for proper B cell and secondary lymphoid tissue formation.</div> </a> <div itemprop="about">Immunity</div> <div itemprop="author">Wuerzberger-Davis SM,Chen Y,Yang DT,Kearns JD,Bates PW,Lynch C,Ladell NC,Yu M,Podd A,Zeng H,Huang TT,Wen R,Hoffmann A,Wang D,Miyamoto S</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Feb 25 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21768304"> <div itemprop="name">Deletion of genes encoding PU.1 and Spi-B in B cells impairs differentiation and induces pre-B cell acute lymphoblastic leukemia.</div> </a> <div itemprop="about">Blood</div> <div itemprop="author">Sokalski KM,Li SK,Welch I,Cadieux-Pitre HA,Gruca MR,DeKoter RP</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to investigate the impairment of differentiation of B cells and induction of pre-B cell acute lymphoblastic leukemia through the deletion of genes encoding PU.1 and Spi-1 in B cells.</div> <div itemprodp="datePublished">Thu Sep 08 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21173107"> <div itemprop="name">Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cells.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Lochner M,Ohnmacht C,Presley L,Bruhns P,Si-Tahar M,Sawa S,Eberl G</div> <div itemprop="description">17-0452 was used in Immunofluorescence to investigate potential for intestinal immunodeficiency compensation by increased lymphoid tissue genesis.</div> <div itemprodp="datePublished">Mon Jan 17 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21204268"> <div itemprop="name">Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice.</div> </a> <div itemprop="about">EMBO molecular medicine</div> <div itemprop="author">Ermakova O,Piszczek L,Luciani L,Cavalli FM,Ferreira T,Farley D,Rizzo S,Paolicelli RC,Al-Banchaabouchi M,Nerlov C,Moriggl R,Luscombe NM,Gross C</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to validate sensitised phenotypic screening of segmental aneuploidy lines as a strategy for systematically identifying disease susceptibility genes in mice.</div> <div itemprodp="datePublished">Sat Jan 01 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21852537"> <div itemprop="name">Validation of MdmX as a therapeutic target for reactivating p53 in tumors.</div> </a> <div itemprop="about">Genes & development</div> <div itemprop="author">Garcia D,Warr MR,Martins CP,Brown Swigart L,Passegué E,Evan GI</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to determine the effects of systemic MdmX inhibition in normal tissues and in tumours.</div> <div itemprodp="datePublished">Mon Aug 15 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21565268"> <div itemprop="name">Mn(III) meso-tetrakis-(N-ethylpyridinium-2-yl) porphyrin mitigates total body irradiation-induced long-term bone marrow suppression.</div> </a> <div itemprop="about">Free radical biology & medicine</div> <div itemprop="author">Li H,Wang Y,Pazhanisamy SK,Shao L,Batinic-Haberle I,Meng A,Zhou D</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to demonstrate that MnTE can mitigate TBI-induced long-term BM suppression by inhibiting IR-induced HSC senescence through the ROS-p16 pathway.</div> <div itemprodp="datePublished">Fri Jul 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21653842"> <div itemprop="name">Role of central leptin signaling in the starvation-induced alteration of B-cell development.</div> </a> <div itemprop="about">The Journal of neuroscience : the official journal of the Society for Neuroscience</div> <div itemprop="author">Tanaka M,Suganami T,Kim-Saijo M,Toda C,Tsuiji M,Ochi K,Kamei Y,Minokoshi Y,Ogawa Y</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to show that the alteration of B-cell development in the bone marrow of fasted and obese mice can be reversed by central leptin administration.</div> <div itemprodp="datePublished">Wed Jun 08 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21264447"> <div itemprop="name">Factor VIII delivered by haematopoietic stem cell-derived B cells corrects the phenotype of haemophilia A mice.</div> </a> <div itemprop="about">Thrombosis and haemostasis</div> <div itemprop="author">Ramezani A,Zweier-Renn LA,Hawley RG</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to provide evidence for B cell-directed protein delivery as a potential clinical approach to treat haemophilia A and other similar disorders.</div> <div itemprodp="datePublished">Fri Apr 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21971520"> <div itemprop="name">Enhanced Toll-like receptor (TLR) responses of TNFR-associated factor 3 (TRAF3)-deficient B lymphocytes.</div> </a> <div itemprop="about">Journal of leukocyte biology</div> <div itemprop="author">Xie P,Poovassery J,Stunz LL,Smith SM,Schultz ML,Carlin LE,Bishop GA</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to show TRAF3 plays varied and cell type-specific, biological roles in TLR responses.</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21854748"> <div itemprop="name">Distinct developmental requirements for isolated lymphoid follicle formation in the small and large intestine: RANKL is essential only in the small intestine.</div> </a> <div itemprop="about">The American journal of pathology</div> <div itemprop="author">Knoop KA,Butler BR,Kumar N,Newberry RD,Williams IR</div> <div itemprop="description">17-0452 was used in Immunofluorescence to study the role of RANKL in the development of cryptopatches and isolated lymphoid follicles within intestinal lymphoid tissues.</div> <div itemprodp="datePublished">Sat Oct 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21430229"> <div itemprop="name">Analysis of the role of IL-21 in development of murine B cell progenitors in the bone marrow.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Simard N,Konforte D,Tran AH,Esufali J,Leonard WJ,Paige CJ</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to provide evidence that IL-21R is functional in B cell progenitors and indicate that IL-21 regulates B cell development.</div> <div itemprodp="datePublished">Sun May 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22043016"> <div itemprop="name">Negative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escape.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Duong BH,Ota T,Aoki-Ota M,Cooper AB,Ait-Azzouzene D,Vela JL,Gavin AL,Nemazee D</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to demonstrate the usefulness of reconstituted IgM(b) superantigen hosts in revealing pathways involved in central tolerance.</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/22043017"> <div itemprop="name">Lung CD103+ dendritic cells efficiently transport influenza virus to the lymph node and load viral antigen onto MHC class I for presentation to CD8 T cells.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Ho AW,Prabhu N,Betts RJ,Ge MQ,Dai X,Hutchinson PE,Lew FC,Wong KL,Hanson BJ,Macary PA,Kemeny DM</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to show that CD11b(low/neg)CD103(+) dendritic cells are functionally specialized for the transport of Ag from the lung to the lymph node.</div> <div itemprodp="datePublished">Thu Dec 01 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21543771"> <div itemprop="name">Sertoli cell-specific deletion of the androgen receptor compromises testicular immune privilege in mice.</div> </a> <div itemprop="about">Biology of reproduction</div> <div itemprop="author">Meng J,Greenlee AR,Taub CJ,Braun RE</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to show that Sertoli cell-specific Ar ablation leads to defective tight junction ultrastructure and elevated IgG in mouse testes.</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21543771"> <div itemprop="name">Sertoli cell-specific deletion of the androgen receptor compromises testicular immune privilege in mice.</div> </a> <div itemprop="about">Biology of reproduction</div> <div itemprop="author">Meng J,Greenlee AR,Taub CJ,Braun RE</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to show that Sertoli cell-specific Ar ablation leads to defective tight junction ultrastructure and elevated IgG in mouse testes.</div> <div itemprodp="datePublished">Mon Aug 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21800103"> <div itemprop="name">Memory T cells persisting in the brain following MCMV infection induce long-term microglial activation via interferon-γ.</div> </a> <div itemprop="about">Journal of neurovirology</div> <div itemprop="author">Mutnal MB,Hu S,Little MR,Lokensgard JR</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to study the migration, persistence, and effects of antigen-specific CD8 T cells in the brain in response to murine cytomegalovirus brain infection.</div> <div itemprodp="datePublished">Sat Oct 01 00:00:00 EDT 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21779371"> <div itemprop="name">PAD4-mediated neutrophil extracellular trap formation is not required for immunity against influenza infection.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Hemmers S,Teijaro JR,Arandjelovic S,Mowen KA</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Tue Nov 15 00:00:00 EST 2011</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20354143"> <div itemprop="name">The death effector domain protein PEA-15 negatively regulates T-cell receptor signaling.</div> </a> <div itemprop="about">FASEB journal : official publication of the Federation of American Societies for Experimental Biology</div> <div itemprop="author">Pastorino S,Renganathan H,Caliva MJ,Filbert EL,Opoku-Ansah J,Sulzmaier FJ,Gawecka JE,Werlen G,Shaw AS,Ramos JW</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to investigate the physiological function of PEA-15, showing that it negatively regulates T-cell receptor signalling.</div> <div itemprodp="datePublished">Sun Aug 01 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20231687"> <div itemprop="name">Peripheral B cell tolerance and function in transgenic mice expressing an IgD superantigen.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Duong BH,Ota T,Aït-Azzouzene D,Aoki-Ota M,Vela JL,Huber C,Walsh K,Gavin AL,Nemazee D</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to generate mice which ubiquitously expressed a membrane-bound IgD-superantigen, to provide a model which should facilitate studies of peripheral B cell tolerance in future.</div> <div itemprodp="datePublished">Thu Apr 15 00:00:00 EDT 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/20083670"> <div itemprop="name">The innate immune response to uropathogenic Escherichia coli involves IL-17A in a murine model of urinary tract infection.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Sivick KE,Schaller MA,Smith SN,Mobley HL</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to show that IL-17A is a key mediator for the innate immune response to UTIs.</div> <div itemprodp="datePublished">Mon Feb 15 00:00:00 EST 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/21057087"> <div itemprop="name">Regulation of follicular B cell differentiation by the related E26 transformation-specific transcription factors PU.1, Spi-B, and Spi-C.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">DeKoter RP,Geadah M,Khoosal S,Xu LS,Thillainadesan G,Torchia J,Chin SS,Garrett-Sinha LA</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to demonstrate the role of the E26 transformation-specific transcription factors PU.1, Spi-B, and Spi-C in follicular B cell development.</div> <div itemprodp="datePublished">Wed Dec 15 00:00:00 EST 2010</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19196865"> <div itemprop="name">A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation.</div> </a> <div itemprop="about">Blood</div> <div itemprop="author">Schuman J,Chen Y,Podd A,Yu M,Liu HH,Wen R,Chen ZJ,Wang D</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Thu May 07 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19144708"> <div itemprop="name">Dendritic cells are required for optimal activation of natural killer functions following primary infection with herpes simplex virus type 1.</div> </a> <div itemprop="about">Journal of virology</div> <div itemprop="author">Kassim SH,Rajasagi NK,Ritz BW,Pruett SB,Gardner EM,Chervenak R,Jennings SR</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to provide evidence that functional DCs are required for optimal IFN-gamma expression and cytolytic function by NK cells following HSV-1 infection.</div> <div itemprodp="datePublished">Wed Apr 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19843942"> <div itemprop="name">c-Myb is required for pro-B cell differentiation.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Fahl SP,Crittenden RB,Allman D,Bender TP</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to demonstrate that c-Myb is absolutely required for the survival and differentiation of CD19(+) B-lineage cells.</div> <div itemprodp="datePublished">Sun Nov 01 00:00:00 EDT 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/19915059"> <div itemprop="name">Endogenous IL-21 restricts CD8+ T cell expansion and is not required for tumor immunity.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Søndergaard H,Coquet JM,Uldrich AP,McLaughlin N,Godfrey DI,Sivakumar PV,Skak K,Smyth MJ</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to reveal novel immunosuppressive actions of interleukin-21.</div> <div itemprodp="datePublished">Tue Dec 01 00:00:00 EST 2009</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18941177"> <div itemprop="name">E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Yang Q,Kardava L,St Leger A,Martincic K,Varnum-Finney B,Bernstein ID,Milcarek C,Borghesi L</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to show E47 controls the developmental integrity and cell cycle quiescence of hematopoietic progenitors.</div> <div itemprodp="datePublished">Sat Nov 01 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/18382684"> <div itemprop="name">p27 deficiency cooperates with Bcl-2 but not Bax to promote T-cell lymphoma.</div> </a> <div itemprop="about">PloS one</div> <div itemprop="author">Cheng N,van de Wetering CI,Knudson CM</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Apr 02 00:00:00 EDT 2008</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/17911603"> <div itemprop="name">Silent development of memory progenitor B cells.</div> </a> <div itemprop="about">Journal of immunology (Baltimore, Md. : 1950)</div> <div itemprop="author">Aviszus K,Zhang X,Wysocki LJ</div> <div itemprop="description">17-0452 was used in Immunofluorescence to support a model of memory B cell development in which extensive affinity/specificity maturation can take place within a B cell clone under some circumstances.</div> <div itemprodp="datePublished">Mon Oct 15 00:00:00 EDT 2007</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/17591700"> <div itemprop="name">Phospholipase Cgamma2 contributes to light-chain gene activation and receptor editing.</div> </a> <div itemprop="about">Molecular and cellular biology</div> <div itemprop="author">Bai L,Chen Y,He Y,Dai X,Lin X,Wen R,Wang D</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Sat Sep 01 00:00:00 EDT 2007</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/16954370"> <div itemprop="name">B-1 B lymphocytes require Blimp-1 for immunoglobulin secretion.</div> </a> <div itemprop="about">The Journal of experimental medicine</div> <div itemprop="author">Savitsky D,Calame K</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to show that Blimp-1 is not necessary for the formation or self-renewal of B-1 B cells but that Blimp-1 is required for normal immunoglobulin (Ig) secretion by B-1 cells.</div> <div itemprodp="datePublished">Mon Oct 02 00:00:00 EDT 2006</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/16477013"> <div itemprop="name">Negative regulation of activation-induced cytidine deaminase in B cells.</div> </a> <div itemprop="about">Proceedings of the National Academy of Sciences of the United States of America</div> <div itemprop="author">Muto T,Okazaki IM,Yamada S,Tanaka Y,Kinoshita K,Muramatsu M,Nagaoka H,Honjo T</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to show that abundant activation-induced cytidine deaminase protein accumulated by constitutive expression, is inactivated in B cells.</div> <div itemprodp="datePublished">Tue Feb 21 00:00:00 EST 2006</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/16571815"> <div itemprop="name">In vivo ablation of CD11c-positive dendritic cells increases susceptibility to herpes simplex virus type 1 infection and diminishes NK and T-cell responses.</div> </a> <div itemprop="about">Journal of virology</div> <div itemprop="author">Kassim SH,Rajasagi NK,Zhao X,Chervenak R,Jennings SR</div> <div itemprop="description">17-0452 was used in Flow cytometry/Cell sorting to investigate the role of different dendritic cell subsets in response to herpes simplex virus type 1 infection in mice.</div> <div itemprodp="datePublished">Sat Apr 01 00:00:00 EST 2006</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/17030619"> <div itemprop="name">Essential role of phospholipase C gamma 2 in early B-cell development and Myc-mediated lymphomagenesis.</div> </a> <div itemprop="about">Molecular and cellular biology</div> <div itemprop="author">Wen R,Chen Y,Bai L,Fu G,Schuman J,Dai X,Zeng H,Yang C,Stephan RP,Cleveland JL,Wang D</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Fri Dec 01 00:00:00 EST 2006</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/15885304"> <div itemprop="name">A role for brain-derived neurotrophic factor in B cell development.</div> </a> <div itemprop="about">Journal of neuroimmunology</div> <div itemprop="author">Schuhmann B,Dietrich A,Sel S,Hahn C,Klingenspor M,Lommatzsch M,Gudermann T,Braun A,Renz H,Nockher WA</div> <div itemprop="description"></div> <div itemprodp="datePublished">Wed Jun 01 00:00:00 EDT 2005</div> <a itemprop="sameAs" href="http://www.ncbi.nlm.nih.gov/pubmed/10454544"> <div itemprop="name">Impaired immune responses and B-cell proliferation in mice lacking the Id3 gene.</div> </a> <div itemprop="about">Molecular and cellular biology</div> <div itemprop="author">Pan L,Sato S,Frederick JP,Sun XH,Zhuang Y</div> <div itemprop="description">Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry</div> <div itemprodp="datePublished">Wed Sep 01 00:00:00 EDT 1999</div> </div> </noscript> </div> <div class="border-bottom"></div> <div class="product-bioinformatics-details"> <div class="container"> <h2 class="pdp-sub-heading">Bioinformatics</h2> <div class="row"> <div class="large-span-6 medium-span-12 small-span-12"> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="proteinContent"> <strong>Protein Aliases:</strong> CD45; CD45 antigen; L-CA; Leukocyte common antigen; Ly-5; Lymphocyte antigen 5; lymphocyte common antigen; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; PTPRC; Receptor-type tyrosine-protein phosphatase C; T200; T200 glycoprotein; T200 leukocyte common antigen </p> <p class="view-buttons" id="ptnViewBtn" ng-class="$ctrl.bioContentLines('proteinContent', 'ptnViewBtn')"> <a id="proteinViewMoreBtn" ng-click="$ctrl.bioContentViewMore('proteinViewMoreBtn', 'proteinViewLessBtn', 'proteinContent')"> View more </a> <a id="proteinViewLessBtn" ng-click="$ctrl.bioContentViewLess('proteinViewLessBtn', 'proteinViewMoreBtn', 'proteinContent')"> View less </a> </p> </div> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="geneContent"> <strong>Gene Aliases:</strong> B220; CD45; CD45R; GP180; L-CA; LCA; loc; Ly-5; LY5; Lyt-4; PTPRC; T200 </p> <p class="view-buttons" id="geneViewBtn" ng-class="$ctrl.bioContentLines('geneContent', 'geneViewBtn')"> <a id="geneViewMoreBtn" ng-click="$ctrl.bioContentViewMore('geneViewMoreBtn', 'geneViewLessBtn', 'geneContent')"> View more </a> <a id="geneViewLessBtn" ng-click="$ctrl.bioContentViewLess('geneViewLessBtn', 'geneViewMoreBtn', 'geneContent')"> View less </a> </p> </div> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="unitProContent"> <strong>UniProt ID:</strong> <a href="http://www.uniprot.org/uniprot/P08575" target="_blank">(Human) P08575</a>, <a href="http://www.uniprot.org/uniprot/P06800" target="_blank">(Mouse) P06800</a> </p> <p class="view-buttons" id="unitViewBtn" ng-class="$ctrl.bioContentLines('unitProContent', 'unitViewBtn')"> <a id="unitProViewMoreBtn" ng-click="$ctrl.bioContentViewMore('unitProViewMoreBtn', 'unitProViewLessBtn', 'unitProContent')"> View more </a> <a id="unitProViewLessBtn" ng-click="$ctrl.bioContentViewLess('unitProViewLessBtn', 'unitProViewMoreBtn', 'unitProContent')"> View less </a> </p> </div> <div class="bioinformatics-wrapper"> <p class="bioinformatics-detail-section" id="entrezContent"> <strong>Entrez Gene ID:</strong> <a href="http://www.ncbi.nlm.nih.gov/gene?term=5788" target="_blank">(Human) 5788</a>, <a href="http://www.ncbi.nlm.nih.gov/gene?term=19264" target="_blank">(Mouse) 19264</a> </p> <p class="view-buttons" id="etzViewBtn" ng-class="$ctrl.bioContentLines('entrezContent', 'etzViewBtn')"> <a id="entrezViewMoreBtn" ng-click="$ctrl.bioContentViewMore('entrezViewMoreBtn', 'entrezViewLessBtn', 'entrezContent')"> View more </a> <a id="entrezViewLessBtn" ng-click="$ctrl.bioContentViewLess('entrezViewLessBtn', 'entrezViewMoreBtn', 'entrezContent')"> View less </a> </p> </div> </div> <div class="large-span-6 medium-span-12 small-span-12"> <div class="accordion" id="accordion-bioinformatics"> <div class="accordion-group"> <div class="accordion-heading"> <a class="accordion-toggle" data-toggle="collapse" data-parent="#accordion2" target="_self" href="#collapseOne"> Function(s) </a> </div> <div id="collapseOne" class="accordion-body collapse"> <div class="accordion-inner"> <a class="icon" href="/antibody/primary/panther/protein tyrosine phosphatase activity"> protein tyrosine phosphatase activity </a> <a class="icon" href="/antibody/primary/panther/transmembrane receptor protein tyrosine phosphatase activity"> transmembrane receptor protein tyrosine phosphatase activity </a> <a class="icon" href="/antibody/primary/panther/protein binding"> protein binding </a> <a class="icon" href="/antibody/primary/panther/protein kinase binding"> protein kinase binding </a> <a class="icon" href="/antibody/primary/panther/phosphoprotein phosphatase activity"> phosphoprotein phosphatase activity </a> <a class="icon" href="/antibody/primary/panther/heparin binding"> heparin binding </a> <a class="icon" href="/antibody/primary/panther/hydrolase activity"> hydrolase activity </a> <a class="icon" href="/antibody/primary/panther/phosphatase activity"> phosphatase activity </a> <a class="icon" href="/antibody/primary/panther/heparan sulfate proteoglycan binding"> heparan sulfate proteoglycan binding </a> <a class="icon" href="/antibody/primary/panther/protein phosphatase"> protein phosphatase </a> <a class="icon" href="/antibody/primary/panther/protein modifying enzyme"> protein modifying enzyme </a> </div> </div> </div> <div class="accordion-group"> <div class="accordion-heading"> <a class="accordion-toggle" data-toggle="collapse" data-parent="#accordion2" target="_self" href="#collapseTwo"> Process(es) </a> </div> <div id="collapseTwo" class="accordion-body collapse"> <div class="accordion-inner"> <a class="icon" href="/antibody/primary/panther/negative regulation of T cell mediated cytotoxicity"> negative regulation of T cell mediated cytotoxicity </a> <a class="icon" href="/antibody/primary/panther/negative regulation of cytokine-mediated signaling pathway"> negative regulation of cytokine-mediated signaling pathway </a> <a class="icon" href="/antibody/primary/panther/hematopoietic progenitor cell differentiation"> hematopoietic progenitor cell differentiation </a> <a class="icon" href="/antibody/primary/panther/immunoglobulin biosynthetic process"> immunoglobulin biosynthetic process </a> <a class="icon" href="/antibody/primary/panther/negative regulation of protein kinase activity"> negative regulation of protein kinase activity </a> <a class="icon" href="/antibody/primary/panther/protein dephosphorylation"> protein dephosphorylation </a> <a class="icon" href="/antibody/primary/panther/negative regulation of cell adhesion involved in substrate-bound cell migration"> negative regulation of cell adhesion involved in substrate-bound cell migration </a> <a class="icon" href="/antibody/primary/panther/cell surface receptor signaling pathway"> cell surface receptor signaling pathway </a> <a class="icon" href="/antibody/primary/panther/dephosphorylation"> dephosphorylation </a> <a class="icon" href="/antibody/primary/panther/T cell differentiation"> T cell differentiation </a> <a class="icon" href="/antibody/primary/panther/positive regulation of B cell proliferation"> positive regulation of B cell proliferation </a> <a class="icon" href="/antibody/primary/panther/peptidyl-tyrosine dephosphorylation"> peptidyl-tyrosine dephosphorylation </a> <a class="icon" href="/antibody/primary/panther/B cell proliferation"> B cell proliferation </a> <a class="icon" href="/antibody/primary/panther/positive regulation of T cell proliferation"> positive regulation of T cell proliferation </a> <a class="icon" href="/antibody/primary/panther/cell cycle phase transition"> cell cycle phase transition </a> <a class="icon" href="/antibody/primary/panther/positive regulation of protein kinase activity"> positive regulation of protein kinase activity </a> <a class="icon" href="/antibody/primary/panther/bone marrow development"> bone marrow development </a> <a class="icon" href="/antibody/primary/panther/stem cell development"> stem cell development </a> <a class="icon" href="/antibody/primary/panther/T cell receptor signaling pathway"> T cell receptor signaling pathway </a> <a class="icon" href="/antibody/primary/panther/B cell receptor signaling pathway"> B cell receptor signaling pathway </a> <a class="icon" href="/antibody/primary/panther/positive regulation of antigen receptor-mediated signaling pathway"> positive regulation of antigen receptor-mediated signaling pathway </a> <a class="icon" href="/antibody/primary/panther/release of sequestered calcium ion into cytosol"> release of sequestered calcium ion into cytosol </a> <a class="icon" href="/antibody/primary/panther/defense response to virus"> defense response to virus </a> <a class="icon" href="/antibody/primary/panther/regulation of cell cycle"> regulation of cell cycle </a> <a class="icon" href="/antibody/primary/panther/positive regulation of hematopoietic stem cell migration"> positive regulation of hematopoietic stem cell migration </a> <a class="icon" href="/antibody/primary/panther/positive regulation of stem cell proliferation"> positive regulation of stem cell proliferation </a> <a class="icon" href="/antibody/primary/panther/activation of MAPK activity"> activation of MAPK activity </a> <a class="icon" href="/antibody/primary/panther/positive regulation of T cell mediated cytotoxicity"> positive regulation of T cell mediated cytotoxicity </a> <a class="icon" href="/antibody/primary/panther/positive regulation of T cell mediated immunity"> positive regulation of T cell mediated immunity </a> <a class="icon" href="/antibody/primary/panther/regulation of humoral immune response mediated by circulating immunoglobulin"> regulation of humoral immune response mediated by circulating immunoglobulin </a> <a class="icon" href="/antibody/primary/panther/positive regulation of humoral immune response mediated by circulating immunoglobulin"> positive regulation of humoral immune response mediated by circulating immunoglobulin </a> <a class="icon" href="/antibody/primary/panther/leukocyte cell-cell adhesion"> leukocyte cell-cell adhesion </a> <a class="icon" href="/antibody/primary/panther/response to gamma radiation"> response to gamma radiation </a> <a class="icon" href="/antibody/primary/panther/B cell differentiation"> B cell differentiation </a> <a class="icon" href="/antibody/primary/panther/negative regulation of protein autophosphorylation"> negative regulation of protein autophosphorylation </a> <a class="icon" href="/antibody/primary/panther/heterotypic cell-cell adhesion"> heterotypic cell-cell adhesion </a> <a class="icon" href="/antibody/primary/panther/T cell proliferation"> T cell proliferation </a> <a class="icon" href="/antibody/primary/panther/positive regulation of MAPK cascade"> positive regulation of MAPK cascade </a> <a class="icon" href="/antibody/primary/panther/positive thymic T cell selection"> positive thymic T cell selection </a> <a class="icon" href="/antibody/primary/panther/negative thymic T cell selection"> negative thymic T cell selection </a> <a class="icon" href="/antibody/primary/panther/regulation of B cell differentiation"> regulation of B cell differentiation </a> <a class="icon" href="/antibody/primary/panther/positive regulation of T cell differentiation"> positive regulation of T cell differentiation </a> <a class="icon" href="/antibody/primary/panther/positive regulation of gamma-delta T cell differentiation"> positive regulation of gamma-delta T cell differentiation </a> <a class="icon" href="/antibody/primary/panther/positive regulation of alpha-beta T cell proliferation"> positive regulation of alpha-beta T cell proliferation </a> <a class="icon" href="/antibody/primary/panther/positive regulation of isotype switching to IgG isotypes"> positive regulation of isotype switching to IgG isotypes </a> <a class="icon" href="/antibody/primary/panther/negative regulation of peptidyl-tyrosine phosphorylation"> negative regulation of peptidyl-tyrosine phosphorylation </a> <a class="icon" href="/antibody/primary/panther/regulation of B cell receptor signaling pathway"> regulation of B cell receptor signaling pathway </a> <a class="icon" href="/antibody/primary/panther/regulation of extrinsic apoptotic signaling pathway"> regulation of extrinsic apoptotic signaling pathway </a> <a class="icon" href="/antibody/primary/panther/positive regulation of extrinsic apoptotic signaling pathway"> positive regulation of extrinsic apoptotic signaling pathway </a> </div> </div> </div> </div> </div> </div> </div> </div> <div class="recommended-products border-bottom hidden">  It has to be done as per old AB suggested Products section. </div> <script type="text/javascript" src="/order/genome-database/assets/core/js/magellanCore.js?version=Local&time=20240917&build-time=2024-11-22T02:34:20+0000"></script> <script type="text/javascript"> $m.addPerformanceMark('abPDPScripts:loadBegin'); </script> <script type="text/javascript" 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