Drug discovery - Latest research and news

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l-with-sidebar__sidebar" style="--with-sidebar--basis: auto"> <li class="ml15 text13"><a href="/subjects/drug-discovery.atom" data-track="click" data-track-category="feeds" data-track-action="link:atom" data-track-label="/subjects/drug-discovery.atom" class="icon icon-left icon-tools-feed-16x16-color pl20">Atom</a></li> <li class="ml15 text13"><a href="/subjects/drug-discovery.rss" data-track="click" data-track-category="feeds" data-track-action="link:rss" data-track-label="/subjects/drug-discovery.rss" class="icon icon-left icon-tools-feed-16x16-color pl20">RSS Feed</a></li> </ul> <section class="u-mb-32"> <button class="text-blue pr20 inline-block position-relative icon-rotate icon-arrow-down-12x7-gray link-like js-hide js-mq640-show" data-toggle="collapsible-section" data-target="definition">Definition</button> <p class="tight-line-height js-mq640-hide" id="definition">Drug discovery is the process through which potential new medicines are identified. It involves a wide range of scientific disciplines, including biology, chemistry and pharmacology. </p> </section> </div> </div> <section class="u-container u-mb-48"><h2 class="c-section-heading">Featured</h2> <ul class="c-list-group c-list-group--lg c-list-group--bordered c-list-group--flush app-article-list-row"> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s44259-024-00058-z" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Conference report of the 2024 Antimicrobial Resistance Meeting</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>The Antimicrobial Resistance - Genomes, Big Data and Emerging Technologies Conference explored key topics including measuring the burden of AMR, global public health pathogen genomics infrastructure and surveillance, translation and implementation of genomics for AMR control, use of techniques such as wastewater surveillance, mathematical and statistical modelling, and Artificial Intelligence (AI) to aid understanding of AMR. This report describes research presented during plenary sessions and discussions, keynote presentations and posters.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Charlotte E. Chong</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Thi Mui Pham</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Kate S. Baker</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">News & Views</span></span><span class="c-meta__item c-meta__item--block-at-lg" itemprop="openAccess" data-test="open-access"><span class="u-color-open-access">Open Access</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-11-29" itemprop="datePublished">29 Nov 2024</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="https://www.nature.com/npjamar" data-track="click" data-track-action="clicked journal" data-track-label="link">npj Antimicrobials and Resistance</a></span> <div class="c-meta__item c-meta__item--block-at-lg" data-test="volume-and-page-info">Volume: 2, P: 43</div> </div> </article> </li> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41594-024-01430-3/MediaObjects/41594_2024_1430_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41594-024-01430-3/MediaObjects/41594_2024_1430_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41594-024-01430-3/MediaObjects/41594_2024_1430_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41594-024-01430-3" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Structural insights into SV2A and the mechanism of racetam anticonvulsants</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>Racetam anticonvulsants, such as levetiracetam, are widely prescribed to treat and prevent seizures. Despite decades of clinical use, their mechanism of action remains unclear. Two studies now reveal the structure of the racetam-binding protein SV2A in complex with anticonvulsant drugs, providing insights into their mechanism of action and the physiology of neurotransmission.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Mazdak M. Bradberry</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Edwin R. Chapman</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">News & Views</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-11-22" itemprop="datePublished">22 Nov 2024</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="https://www.nature.com/nsmb" data-track="click" data-track-action="clicked journal" data-track-label="link">Nature Structural & Molecular Biology</a></span> <div class="c-meta__item c-meta__item--block-at-lg" data-test="volume-and-page-info">P: 1-3</div> </div> </article> </li> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/magazine-assets/d41586-024-03548-2/d41586-024-03548-2_27714984.png?as=webp 160w, https://media.springernature.com/w290h158/magazine-assets/d41586-024-03548-2/d41586-024-03548-2_27714984.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/magazine-assets/d41586-024-03548-2/d41586-024-03548-2_27714984.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/d41586-024-03548-2" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Two for one: candidate obesity drug boosts energy use and curbs calorie intake</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>The discovery of a pathway that controls appetite and calorie burning has led to the development of a drug that modulates both by targeting one receptor, offering a promising strategy for weight loss and improved metabolic health.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Carlos G. Ardanaz</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Sophie M. Steculorum</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">News & Views</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-11-13" itemprop="datePublished">13 Nov 2024</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="https://www.nature.com/nature" data-track="click" data-track-action="clicked journal" data-track-label="link">Nature</a></span> <div class="c-meta__item c-meta__item--block-at-lg" data-test="volume-and-page-info">Volume: 635, P: 823-825</div> </div> </article> </li> </ul> </section> <section class="u-container u-mb-48 u-pb-24"> <h2 class="c-section-heading">Related Subjects</h2> <ul class="ma0 clean-list tighten-line-height grid-auto-fill no-row-gap" id="related-subjects-list"> <li class="pb4"> <a href="/subjects/biologics" class="subject-tag-link text14" data-track="click" 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href="/articles/s41598-024-77106-1" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Cutting-edge Bioinformatics strategies for synthesizing Cyclotriazadisulfonamide (CADA) analogs in next-Generation HIV therapies</a> </h3> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Jay Gabriel B. 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u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41598-024-81287-0/MediaObjects/41598_2024_81287_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41598-024-81287-0/MediaObjects/41598_2024_81287_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41598-024-81287-0/MediaObjects/41598_2024_81287_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41598-024-81287-0" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">The potential inhibitory mechanism of EGCG against the Chikungunya virus targeting non-structural protein 2 through molecular dynamics simulation</a> </h3> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Inda Setyawati</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Aprijal Ghiyas Setiawan</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Keni Vidilaseris</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Research</span></span><span class="c-meta__item c-meta__item--block-at-lg" itemprop="openAccess" data-test="open-access"><span class="u-color-open-access">Open Access</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-11-30" itemprop="datePublished">30 Nov 2024</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="https://www.nature.com/srep" data-track="click" data-track-action="clicked journal" data-track-label="link">Scientific Reports</a></span> <div class="c-meta__item c-meta__item--block-at-lg" data-test="volume-and-page-info">Volume: 14, P: 29797</div> </div> </article> </li> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41598-024-79832-y/MediaObjects/41598_2024_79832_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41598-024-79832-y/MediaObjects/41598_2024_79832_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41598-024-79832-y/MediaObjects/41598_2024_79832_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41598-024-79832-y" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">In sight on olive oil maceration and supercritical CO<sub>2</sub> in extracting rosemary essential oil</a> </h3> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Maha Mohamed Soltan</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Sabry Mahfouz</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Ali El-Hagrassi</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Research</span></span><span class="c-meta__item c-meta__item--block-at-lg" itemprop="openAccess" data-test="open-access"><span class="u-color-open-access">Open Access</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-11-29" itemprop="datePublished">29 Nov 2024</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="https://www.nature.com/srep" data-track="click" data-track-action="clicked journal" data-track-label="link">Scientific Reports</a></span> <div class="c-meta__item c-meta__item--block-at-lg" data-test="volume-and-page-info">Volume: 14, P: 29730</div> </div> </article> </li> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41392-024-02035-4/MediaObjects/41392_2024_2035_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41392-024-02035-4/MediaObjects/41392_2024_2035_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41392-024-02035-4/MediaObjects/41392_2024_2035_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41392-024-02035-4" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Nucleic acid drugs: recent progress and future perspectives</a> </h3> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Xiaoyi Sun</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Sarra Setrerrahmane</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Hanmei Xu</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Reviews</span></span><span class="c-meta__item c-meta__item--block-at-lg" itemprop="openAccess" data-test="open-access"><span class="u-color-open-access">Open Access</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-11-29" itemprop="datePublished">29 Nov 2024</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="https://www.nature.com/sigtrans" data-track="click" data-track-action="clicked journal" data-track-label="link">Signal Transduction and Targeted Therapy</a></span> <div class="c-meta__item c-meta__item--block-at-lg" data-test="volume-and-page-info">Volume: 9, P: 316</div> </div> </article> </li> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41598-024-80326-0/MediaObjects/41598_2024_80326_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41598-024-80326-0/MediaObjects/41598_2024_80326_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41598-024-80326-0/MediaObjects/41598_2024_80326_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41598-024-80326-0" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Using X-ray velocimetry to measure lung function and assess the efficacy of a <i>pseudomonas aeruginosa</i> bacteriophage therapy for cystic fibrosis</a> </h3> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Stephanie A. Harker</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Melissa Preissner</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Kaye S. Morgan</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Research</span></span><span class="c-meta__item c-meta__item--block-at-lg" itemprop="openAccess" data-test="open-access"><span class="u-color-open-access">Open Access</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-11-29" itemprop="datePublished">29 Nov 2024</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="https://www.nature.com/srep" data-track="click" data-track-action="clicked journal" data-track-label="link">Scientific Reports</a></span> <div class="c-meta__item c-meta__item--block-at-lg" data-test="volume-and-page-info">Volume: 14, P: 29727</div> </div> </article> </li> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__image"> <picture> <source type="image/webp" srcset=" https://media.springernature.com/w165h90/springer-static/image/art%3A10.1038%2Fs41467-024-54382-z/MediaObjects/41467_2024_54382_Fig1_HTML.png?as=webp 160w, https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41467-024-54382-z/MediaObjects/41467_2024_54382_Fig1_HTML.png?as=webp 290w" sizes=" (max-width: 640px) 160px, (max-width: 1200px) 290px, 290px"> <img src="https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41467-024-54382-z/MediaObjects/41467_2024_54382_Fig1_HTML.png" alt="" itemprop="image"> </picture> </div> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s41467-024-54382-z" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link"><i>γ</i>-Glutamyl transpeptidase-activable nanoprobe crosses the blood-brain barrier for immuno-sonodynamic therapy of glioma</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 u-hide-sm-max" itemprop="description"> <p>Chemotherapy of glioma is limited by delivering drugs across blood-brain barrier (BBB) to tumor sites in brain. Here, this group designs a neutrally-charged nanoprobe with γ-glutamyl moieties decorated on the surface that enabling the effective delivery of sonosensitizer and immune agonist R848 across BBB through adsorptive mediated transcytosis, thereby eliciting the anticancer effects.</p> </div> <ul data-test="author-list" class="c-author-list c-author-list--compact c-author-list--truncated"> <li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Bo Li</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Gengjia Chen</span></li><li itemprop="creator" itemscope="" itemtype="http://schema.org/Person"><span itemprop="name">Xintao Shuai</span></li> </ul> </div> </div> <div class="c-card__section c-meta"> <span class="c-meta__item c-meta__item--block-at-lg" data-test="article.type"><span class="c-meta__type">Research</span></span><span class="c-meta__item c-meta__item--block-at-lg" itemprop="openAccess" data-test="open-access"><span class="u-color-open-access">Open Access</span></span><time class="c-meta__item c-meta__item--block-at-lg" datetime="2024-11-29" itemprop="datePublished">29 Nov 2024</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="https://www.nature.com/ncomms" data-track="click" data-track-action="clicked journal" data-track-label="link">Nature Communications</a></span> <div class="c-meta__item c-meta__item--block-at-lg" data-test="volume-and-page-info">Volume: 15, P: 10418</div> </div> </article> </li> </ul> <div class="position-left last text-center u-mb-48"> <a href="/search?article_type=protocols,research,reviews&subject=drug-discovery" class="pill-button inline-block" data-track="click" data-track-action="link:view-all" data-track-category="latest-research" data-track-label="All Research & Reviews"><span>All Research & Reviews</span></a> </div> <section class="u-container u-mb-48"> <div id="div-gpt-ad-article-list-2" class="div-gpt-ad 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datetime="2024-11-29" itemprop="datePublished">29 Nov 2024</time> <span class="c-meta__item c-meta__item--block-at-lg"><a href="https://www.nature.com/nbt" data-track="click" data-track-action="clicked journal" data-track-label="link">Nature Biotechnology</a></span> <div class="c-meta__item c-meta__item--block-at-lg" data-test="volume-and-page-info">P: 1-2</div> </div> </article> </li> <li class="app-article-list-row__item"> <article class="u-full-height c-card c-card--flush" itemscope itemtype="http://schema.org/ScholarlyArticle"> <div class="c-card__layout u-full-height"> <div class="c-card__body u-display-flex u-flex-direction-column"> <h3 class="c-card__title" itemprop="name headline"> <a href="/articles/s44259-024-00058-z" class="u-link-inherit" itemprop="url" data-track="click" data-track-action="view article" data-track-label="link">Conference report of the 2024 Antimicrobial Resistance Meeting</a> </h3> <div data-test="article-description" class="c-card__summary u-mb-16 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