Ets1 and Elk1 transcription factors regulate cancerous inhibitor of protein phosphatase 2A expression in cervical and endometrial carcinoma cells

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CIP2A acts by inhibiting protein phosphatase 2A-dependent destabilization of c-Myc, resulting in increased cell proliferation. Here, we have characte …"><meta name="keywords" content="pmid:23117818, PMC3630189, doi:10.4161/trns.22518, Research Support, Non-U.S. Gov't, Rajash Pallai, Aishwarya Bhaskar, Lyndi M Rice, Autoantigens / genetics, Autoantigens / metabolism*, Binding Sites, Biomarkers, Tumor / genetics, Biomarkers, Tumor / metabolism, Cell Line, Tumor, Endometrial Neoplasms / metabolism*, Female, Humans, Intracellular Signaling Peptides and Proteins, Membrane Proteins / genetics, Membrane Proteins / metabolism*, Mutagenesis, Site-Directed, Promoter Regions, Genetic, Proto-Oncogene Mas, Proto-Oncogene Protein c-ets-1 / genetics, Proto-Oncogene Protein c-ets-1 / metabolism*, Uterine Cervical Neoplasms / metabolism*, ets-Domain Protein Elk-1 / genetics, ets-Domain Protein Elk-1 / metabolism*, PubMed Abstract, NIH, NLM, NCBI, National Institutes of Health, National Center for Biotechnology Information, National Library of Medicine, MEDLINE"><meta name="robots" content="index,nofollow,noarchive"><meta property="og:title" content="Ets1 and Elk1 transcription factors regulate cancerous inhibitor of protein phosphatase 2A expression in cervical and endometrial carcinoma cells - PubMed"><meta property="og:url" content="https://pubmed.ncbi.nlm.nih.gov/23117818/"><meta property="og:description" content="Cancerous inhibitor of protein phosphatase 2A (CIP2A) has been identified as a proto-oncogene that is overexpressed in various types of human cancers. CIP2A acts by inhibiting protein phosphatase 2A-dependent destabilization of c-Myc, resulting in increased cell proliferation. Here, we have characte …"><meta property="og:image" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg"><meta property="og:image:secure_url" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg"><meta property="og:type" content="website"><meta property="og:site_name" content="PubMed"><meta name="twitter:domain" content="pubmed.ncbi.nlm.nih.gov"><meta name="twitter:card" content="summary_large_image"><meta name="twitter:title" content="Ets1 and Elk1 transcription factors regulate cancerous inhibitor of protein phosphatase 2A expression in cervical and endometrial carcinoma cells - PubMed"><meta name="twitter:url" content="https://pubmed.ncbi.nlm.nih.gov/23117818/"><meta name="twitter:description" content="Cancerous inhibitor of protein phosphatase 2A (CIP2A) has been identified as a proto-oncogene that is overexpressed in various types of human cancers. CIP2A acts by inhibiting protein phosphatase 2A-dependent destabilization of c-Myc, resulting in increased cell proliferation. Here, we have characte …"><meta name="twitter:image" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg">  <link rel="search" type="application/opensearchdescription+xml" href="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/opensearch.xml" title="PubMed search">  <noscript> <link rel="stylesheet" type="text/css" href="https://cdn.ncbi.nlm.nih.gov/pubmed/ed1a5a1f-b279-475e-88e3-75f261729818/core/no-script.css"> </noscript> <meta name="citation_title" content="Ets1 and Elk1 transcription factors regulate cancerous inhibitor of protein phosphatase 2A expression in cervical and endometrial carcinoma cells"> <meta name="citation_authors" content="Pallai R;Bhaskar A;Sodi V;Rice LM;"> <meta name="citation_date" content="2012 Nov-Dec"> <meta name="citation_publisher" content="Transcription"> <meta name="citation_journal_title" content="Transcription"> <meta name="citation_pmid" content="23117818"> <meta name="citation_abstract_html_url" content="https://pubmed.ncbi.nlm.nih.gov/23117818/"> <meta name="citation_volume" content="3"> <meta name="citation_issue" content="6"> <meta name="citation_doi" content="10.4161/trns.22518"> <meta name="citation_issn" content="2154-1272"> <link rel="canonical" href="https://pubmed.ncbi.nlm.nih.gov/23117818/" /> </head> <body > <noscript> <div class="no-script-banner" id="no-script-banner"> <div class="warning-message"> <div class="warning-message-text"> This site needs JavaScript to work properly. 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new collection</label> </li> <li> <input type="radio" id="collections-action-panel-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="save_share" data-ga-action="collections" data-ga-label="collections_radio_existing"> <label for="collections-action-panel-existing">Add to an existing collection</label> </li> </ul> </div> <div class="controls-wrapper"> <div class="action-panel-control-wrap new-collections-controls"> <label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label> <input type="text" name="add-to-new-collection" id="collections-action-panel-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="save_share" data-ga-action="create_collection" data-ga-label="non_favorties_collection"> <div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div> </div> <div class="action-panel-control-wrap existing-collections-controls"> <label for="collections-action-panel-add-to-existing" class="action-panel-label"> Choose a collection: </label> <select id="collections-action-panel-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="save_share" data-ga-action="select_collection" data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"> </select> <div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br> <a href="#">Please try again</a> </div> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="save_share" data-ga-action="collections" data-ga-label="add"> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="collections" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="bibliography-action-panel" class="bibliography-action-panel action-panel in-progress-dots-panel" aria-hidden="true" data-bibliography-open-panel-enabled="false" data-bibliography-open-panel-url-hash="#open-bibliography-panel"> <div class="inner-wrap"> <h3 class="action-panel-heading"> Add to My Bibliography </h3> <form id="bibliography-action-panel-form" class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-add-to-bibliography-max-amount="100" data-add-to-bibliography-batch-size="10" data-bibliography-delegates-url="/list-bibliography-delegates/" data-add-to-bibliography-url="/add-to-bibliography/" data-get-article-ids-by-search-url="/get-article-ids-by-search/" data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/"> <input type="hidden" name="csrfmiddlewaretoken" value="T5OgW38ywT6WD8yrbds3wuQJD64xqWle2oRWaObJ0WwjRe1LrYicokqqNJMdaOUs"> <div class="action-panel-control-wrap bibliographies-controls"> <div class="choice-group"> <ul class="bibliographies-action-add radio-group-items"> <li> <input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/> <label for="my-bibliography">My Bibliography</label> </li> </ul> </div> </div> <div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your delegates due to an error<br> <a href="#">Please try again</a> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to bibliography' panel" ref="linksrc=close_bibliography_panel" aria-controls="bibliography-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="mybib" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true" data-saved-search-open-panel-enabled="false" data-saved-search-open-panel-url-hash="#open-saved-search-panel"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your saved search </h2> <form id="saved-search-action-panel-form" class="saved-search-action-panel-form action-panel-content action-form" data-create-saved-search-url="/create-saved-search/" data-try-search-terms-url="/try-search-term/" data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/"> <input type="hidden" name="csrfmiddlewaretoken" value="T5OgW38ywT6WD8yrbds3wuQJD64xqWle2oRWaObJ0WwjRe1LrYicokqqNJMdaOUs"> <div class="action-panel-control-wrap"> <label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk"> Name of saved search: </label> <input maxlength="200" type="text" name="saved-search-name" id="saved-search-name" class="saved-search-name" value="" required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="action-panel-control-wrap"> <label for="saved-search-term" class="action-panel-label required-field-asterisk"> Search terms: </label> <textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea> </div> <div class="test-search-term-wrap"> <a href="#" class="try-search-term">Test search terms</a> </div> <div class="choice-group action-panel-extra-margin-top"> <span class="action-panel-label" id="fieldset-label"> Would you like email updates of new search results? </span> <fieldset id="saved-search-alert" aria-describedby="fieldset-label"> <legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend> <ul class="radio-group-items"> <li> <input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked> <label for="saved-search-alert-yes" class="action-panel-label">Yes</label> </li> <li> <input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no"> <label for="saved-search-alert-no" class="action-panel-label">No</label> </li> </ul> </fieldset> </div> <div class="alert-schedule-wrap"> <div class="action-panel-control-wrap"> <label class="action-panel-label"> Email: </label> <span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span> </div> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="saved-search-frequency" class="action-panel-label"> Frequency: </label> <select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency"> <option value="monthly">Monthly</option> <option value="weekly">Weekly</option> <option value="daily">Daily</option> </select> </div> <div class="action-panel-control-wrap saved-search-monthly-additional"> <label for="saved-search-monthly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-monthly-on-day" class="no-border-panel-selector"> <option value="Sunday">The first Sunday</option> <option value="Monday">The first Monday</option> <option value="Tuesday">The first Tuesday</option> <option value="Wednesday">The first Wednesday</option> <option value="Thursday">The first Thursday</option> <option value="Friday">The first Friday</option> <option value="Saturday">The first Saturday</option> <option value="day">The first day</option> <option value="weekday">The first weekday</option> </select> </div> <div class="action-panel-control-wrap saved-search-weekly-additional"> <label for="saved-search-weekly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day"> <option value="Sunday">Sunday</option> <option value="Monday">Monday</option> <option value="Tuesday">Tuesday</option> <option value="Wednesday">Wednesday</option> <option value="Thursday">Thursday</option> <option value="Friday">Friday</option> <option value="Saturday">Saturday</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-report" class="action-panel-label"> Report format: </label> <select id="saved-search-report" class="no-border-panel-selector saved-search-report"> <option value="DocSum">Summary</option> <option value="DocSumText">Summary (text)</option> <option value="Abstract">Abstract</option> <option value="AbstractText">Abstract (text)</option> <option value="MEDLINE">PubMed</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-amount" class="action-panel-label"> Send at most: </label> <select id="saved-search-amount" class="no-border-panel-selector saved-search-amount"> <option value="1">1 item</option> <option value="5" selected>5 items</option> <option value="10">10 items</option> <option value="20">20 items</option> <option value="50">50 items</option> <option value="100">100 items</option> <option value="200">200 items</option> </select> </div> <div> <input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result"> <label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox"> Send even when there aren't any new results </label> </div> <div class="action-panel-control-wrap option-text-in-email-wrap"> <label for="saved-search-email-text" class="action-panel-label"> Optional text in email: </label> <textarea name="saved-search-email-text" id="saved-search-email-text" class="saved-search-email-text"></textarea> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Saving..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Save </button> <button class="action-panel-cancel" aria-label="Close 'Your saved search' panel" ref="linksrc=close_saved_search_panel" aria-controls="saved-search-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Create a file for external citation management software </h2> <form id="citation-manager-action-panel-form" class="action-panel-content action-form" action="/results-export-ids/" data-by-search-action="/results-export-search-data/" data-by-ids-action="/results-export-ids/" method="post" data-by-search-method="post" data-by-ids-method="post"> <input type="hidden" name="csrfmiddlewaretoken" value="T5OgW38ywT6WD8yrbds3wuQJD64xqWle2oRWaObJ0WwjRe1LrYicokqqNJMdaOUs"> <input name="results-format" type="hidden" value="pubmed"/> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Sending..." data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="save"> Create file </button> <button class="action-panel-cancel" aria-label="Close 'Send citations to citation manager' panel" ref="linksrc=close_citation_manager_panel" aria-controls="citation-manager-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your RSS Feed </h2> <form id="rss-action-panel-form" class="rss-action-panel-form action-panel-content action-form" data-create-rss-feed-url="/create-rss-feed-url/" data-search-form-term-value=""> <input type="hidden" name="csrfmiddlewaretoken" value="T5OgW38ywT6WD8yrbds3wuQJD64xqWle2oRWaObJ0WwjRe1LrYicokqqNJMdaOUs"> <div class="action-panel-control-wrap"> <label for="rss-name" class="action-panel-label required-field-asterisk"> Name of RSS Feed: </label> <input maxlength="200" placeholder="Name" type="text" name="rss-name" id="rss-name" class="rss-name" value='' required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="rss-limit-wrap"> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="rss-limit" class="action-panel-label"> Number of items displayed: </label> <select id="rss-limit" class="no-border-panel-selector rss-limit"> <option value="5">5</option> <option value="10">10</option> <option value="15" selected="selected">15</option> <option value="20">20</option> <option value="50">50</option> <option value="100">100</option> </select> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Creating..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Create RSS </button> <button class="action-panel-cancel" aria-label="Close 'Your RSS' panel" ref="linksrc=close_rss_panel" aria-controls="rss-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> <div class="action-panel-control-wrap rss-link-copy-wrap"> <label for="rss-link" class="usa-sr-only">RSS Link</label> <input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link"> <button type="button" disabled class="rss-link-copy-button disabled" data-ga-category="save_share" data-ga-action="rss" data-ga-label="copy"> Copy </button> </div> </form> </div> </div> </div> </div> <div class="article-page" id="article-page" data-article-pmid="23117818"> <aside class="page-sidebar"> <div class="inner-wrap"> <div class="full-text-links"> <div class="full-view"> <h3 class="title"> Full text links </h3> <div class="full-text-links-list"> <a class="link-item dialog-focus" href="https://www.tandfonline.com/doi/full/10.4161/trns.22518" target="_blank" rel="noopener" ref="linksrc=fulltextorjournal_fulltext&is_pmc=False&PrId=3079&itool=Abstract-def&log$=linkouticon&uid=23117818&db=pubmed&nlmid=101530967" title="See full text options at Taylor & Francis" data-ga-category="full_text" data-ga-action="Taylor & Francis" data-ga-label="23117818" ><img src="https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--www.tandfonline.com-pb-assets-tandf-logos-tf_pubmed_fulltext_icon-1718004442.png" alt="full text provider logo"><span class="text"> Taylor & Francis </span></a><a class="link-item pmc " href="https://pmc.ncbi.nlm.nih.gov/articles/pmid/23117818/" target="_blank" rel="noopener" ref="linksrc=fulltextorjournal_fulltext&is_pmc=True&PrId=3494&itool=Abstract-def&log$=linkouticon&uid=23117818&db=pubmed&nlmid=101530967" title="Free full text at PubMed Central" data-ga-category="full_text" data-ga-action="PMC" data-ga-label="23117818" ><span class="text"> Free PMC 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name="csrfmiddlewaretoken" value="T5OgW38ywT6WD8yrbds3wuQJD64xqWle2oRWaObJ0WwjRe1LrYicokqqNJMdaOUs"><div class="choice-group" role="radiogroup"><ul class="radio-group-items"><li><input type="radio" id="collections-action-dialog-new" class="collections-new" name="collections" value="new" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_new"><label for="collections-action-dialog-new">Create a new collection</label></li><li><input type="radio" id="collections-action-dialog-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_existing"><label for="collections-action-dialog-existing">Add to an existing collection</label></li></ul></div><div class="controls-wrapper"><div class="action-panel-control-wrap new-collections-controls"><label for="collections-action-dialog-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label><input type="text" name="add-to-new-collection" id="collections-action-dialog-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="collections_button" data-ga-action="create_collection" data-ga-label="non_favorties_collection"><div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div></div><div class="action-panel-control-wrap existing-collections-controls"><label for="collections-action-dialog-add-to-existing" class="action-panel-label"> Choose a collection: </label><select id="collections-action-dialog-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="collections_button" data-ga-action="select_collection" data-ga-label="($('.collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"></select><div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br><a href="#">Please try again</a></div></div></div><div class="action-panel-actions"><button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="collections_button" data-ga-action="click" data-ga-label="add"> Add </button><button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="collections_button" data-ga-action="click" data-ga-label="cancel"> Cancel </button></div></form></div></div></div></div><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" 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to Search </a></li></ul></div></div></div><span class="period">. </span><span class="cit">2012 Nov-Dec;3(6):323-35.</span> </div> <span class="citation-doi"> doi: 10.4161/trns.22518. </span> <span class="secondary-date"> Epub 2012 Nov 1. </span> </div> <h1 class="heading-title"> Ets1 and Elk1 transcription factors regulate cancerous inhibitor of protein phosphatase 2A expression in cervical and endometrial carcinoma cells </h1> <div class="inline-authors"> <div class="authors"> <div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Pallai+R&cauthor_id=23117818" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Rajash Pallai">Rajash Pallai</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Cancer Signaling and Cell Cycle, Venenum Biodesign, L.L.C, Hamilton, NJ, USA." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Bhaskar+A&cauthor_id=23117818" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Aishwarya Bhaskar">Aishwarya Bhaskar</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Sodi+V&cauthor_id=23117818" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Valerie Sodi">Valerie Sodi</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Rice+LM&cauthor_id=23117818" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Lyndi M Rice">Lyndi M Rice</a></span> </div> </div> </div> <div class="short-article-details"> Affiliations <button class="more-details" id="toggle-authors" data-alt-text="Collapse" aria-controls="expanded-authors" 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href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Bhaskar+A&cauthor_id=23117818" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Aishwarya Bhaskar">Aishwarya Bhaskar</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Sodi+V&cauthor_id=23117818" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Valerie Sodi">Valerie Sodi</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Rice+LM&cauthor_id=23117818" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Lyndi M Rice">Lyndi M Rice</a></span> </div> </div> <div class="affiliations"> <h3 class="title"> Affiliation </h3> <ul class="item-list"> <li data-affiliation-id="short-view-affiliation-1" id="short-view-affiliation-1" ><sup class="key">1</sup> Department of Cancer Signaling and Cell Cycle, Venenum Biodesign, L.L.C, Hamilton, NJ, USA.</li> </ul> </div> </div> <ul class="identifiers" id="short-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">23117818</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=PMC3630189&id_type=PMC" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC3630189/" data-ga-category="full_text" data-ga-action="PMCID" > PMC3630189 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.4161/trns.22518&id_type=DOI" href="https://doi.org/10.4161/trns.22518" 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data-default-format-value="abstract" data-current-format-value="abstract" role="region"><button class="trigger usa-button" title="Change format" data-ga-category="display_options" data-ga-action="display_options_dialog"><span class="button-label">Display options</span></button><div class="dropdown" hidden><div class="title"> Display options </div><div class="content"><div class="format-container"><span class="option-label"> Format </span><select name="format" data-initial-value="abstract" aria-label="Display format" id="inline-actions-display-format"><option value="abstract">Abstract</option><option value="pubmed">PubMed</option><option value="pmid">PMID</option></select></div></div></div></div></div></div> <div class="abstract" id="abstract"> <h2 class="title"> Abstract </h2> <div class="abstract-content selected" id="eng-abstract"> <p> Cancerous inhibitor of protein phosphatase 2A (CIP2A) has been identified as a proto-oncogene that is overexpressed in various types of human cancers. CIP2A acts by inhibiting protein phosphatase 2A-dependent destabilization of c-Myc, resulting in increased cell proliferation. Here, we have characterized the proximal promoter region of the human CIP2A gene in cervical, endometrial and liver carcinoma cells. The 5' flanking minimal proximal promoter of the CIP2A gene consists of putative binding sites for Ets1 and Elk1 in forward and reverse orientations. Here, we show that Ets1 and Elk1 binding is essential for CIP2A basal expression in several urogenital cancer cell lines. Interestingly, both Ets1 and Elk1 are required together for CIP2A expression, as siRNA knockdown of Ets1 and Elk1 together decreased CIP2A gene transcription, whereas knockdown of Ets1 or Elk1 alone had no effect. Moreover, ectopic expression of Ets1 and Elk1 together increased CIP2A expression. To gain physiological significance of the Ets1 and Elk1 regulation we observed, a panel of matched human cervical carcinoma samples was analyzed for the expression of CIP2A and Ets1 and/or Elk1. We found a direct correlation between the levels of CIP2A and the levels of Ets1 and Elk1. Our results suggest that the binding of Ets1 and Elk1 together to the proximal CIP2A promoter is absolutely required for CIP2A expression in cervical, endometrial and liver carcinoma cell lines. Thus, different factors regulate CIP2A expression in a cell-type specific manner. As previous work has shown a requirement for only Ets1 in prostate and gastric carcinomas, our results now indicate that CIP2A regulation is more complex than previously determined. </p> </div> <p> <strong class="sub-title"> Keywords: </strong> CIP2A; Elk1; Ets1; PP2A; biomarkers; cancer; p90. </p> </div> <p class="disclaimer" id="disclaimer"> <a href="/disclaimer/" target="_blank" ga_category="literature_resources" ga_action="disclaimer_link" ga_label="under_abstract">PubMed Disclaimer</a> </p> <div class="figures" id="figures"> <h2 class="title"> Figures </h2> <div class="figures-list" id="slides-container" itemscope itemtype="http://schema.org/ImageGallery"> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="0" data-label-slug="captionless-figure"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ba/3630189/0eac5ddf6c54/tran-3-323-g1.jpg" itemprop="contentUrl" aria-describedby="figure-caption-0" role="button" data-image-width="620" data-image-height="683" data-image-alt="captionless-figure" data-pmc-id="PMC3630189" data-figure-id="F1"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-0" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ba/3630189/78abf558c186/tran-3-323-g1.gif" alt="None" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="620"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="683"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <div class="figure-caption-contents"><b> Figure 1. </b> Transcription factor binding sites of…</div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <div class="figure-caption-contents"><b> Figure 1. </b> Transcription factor binding sites of the <i> CIP2A </i> proximal promoter. The 5′ flanking region…</div> </div> <figcaption id="figure-caption-0" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <div class="figure-caption-contents"><b>Figure 1.</b> Transcription factor binding sites of the <i>CIP2A</i> proximal promoter. The 5′ flanking region of the <i>CIP2A</i> promoter is shown with the transcription start site (TSS) indicated at +1. The sequence has been numbered from the TSS. The following potential transcription factor binding sites were identified: 1, Glucocorticoid receptor α; 2, Retinoic acid receptor α; 3, Pax5; 4, Ets1; 5, Elk1; 6, NF-κB; 7, Sp1; and 8, AP-2—using the ALGEN-PROMO or Ali-baba 2.0 computational software. The region between −171 and −95 has Ets1/Elk1 palindromic binding sites, which are important for basal expression of human CIP2A.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="1" data-label-slug="captionless-figure"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ba/3630189/c5b0719c26af/tran-3-323-g2.jpg" itemprop="contentUrl" aria-describedby="figure-caption-1" role="button" data-image-width="718" data-image-height="582" data-image-alt="captionless-figure" data-pmc-id="PMC3630189" data-figure-id="F2"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-1" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ba/3630189/8db588dda0d0/tran-3-323-g2.gif" alt="None" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="718"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="582"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <div class="figure-caption-contents"><b> Figure 2. </b> Identification of the <i> CIP2A </i> proximal…</div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <div class="figure-caption-contents"><b> Figure 2. </b> Identification of the <i> CIP2A </i> proximal promoter region. (A) and (D) Diagrammatic representation of…</div> </div> <figcaption id="figure-caption-1" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <div class="figure-caption-contents"><b>Figure 2.</b> Identification of the <i>CIP2A</i> proximal promoter region. (A) and (D) Diagrammatic representation of the full length and sequentially deleted <i>CIP2A</i> promoter constructs used in this study. The transcription start site (TSS) is numbered as +1 and the constructs are numbered with reference to the TSS from 5′–3′ ends. (B) Human cervical carcinoma cells (HeLa), (C) liver hepatobalstoma cells (HepG2), and (E) endometrial carcinoma cells (ECC-1) were transfected with <i>CIP2A</i> promoter constructs shown in Figure 2A or 2D and assayed for luciferase activity after 48 h as described in the Materials and Methods. Fold increase in relative luciferase activity (RLA) was compared with pGL4-basic (set as 1). Normalization in transfection efficiency was performed by co-transfection with pRL-TK (<i>Renilla</i> expression vector). The mean ± SD are from three different experiments, each performed in triplicate.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="2" data-label-slug="captionless-figure"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ba/3630189/ef4a172dc70b/tran-3-323-g3.jpg" itemprop="contentUrl" aria-describedby="figure-caption-2" role="button" data-image-width="737" data-image-height="704" data-image-alt="captionless-figure" data-pmc-id="PMC3630189" data-figure-id="F3"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-2" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ba/3630189/41217bd2c53d/tran-3-323-g3.gif" alt="None" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="737"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="704"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <div class="figure-caption-contents"><b> Figure 3. </b> The Ets1 and Elk1 binding…</div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <div class="figure-caption-contents"><b> Figure 3. </b> The Ets1 and Elk1 binding sites control transcription of <i> CIP2A </i> . (A) Six…</div> </div> <figcaption id="figure-caption-2" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <div class="figure-caption-contents"><b>Figure 3.</b> The Ets1 and Elk1 binding sites control transcription of <i>CIP2A</i>. (A) Six different mutants were constructed as explained in Materials and Methods. Mutated binding sites in the <i>CIP2A</i> promoter region are indicated in bold and are underlined. Deletions are indicated in bold, italics, and are underlined. <i>CIP2A</i> Mut1 targeted the binding sites for transcription factor NF-κB, <i>CIP2A</i> Mut2 targeted the binding site for transcription factor Ets1, <i>CIP2A</i> Mut3 was targeted toward the Elk1 binding site, and <i>CIP2A</i> Mut4 targeted the binding site for transcription factor Pax5, while <i>CIP2A</i> Mut5 and <i>CIP2A</i> Mut6 targeted the binding sites for Ets1 and Elk1. (B) HeLa and (C) ECC-1 cells were transfected with a mutant clone or the wild-type promoter (<i>CIP2A</i> -171/+70) and assayed for luciferase activity after 48 h as described in Figure 2. Transfection efficiency was normalized by co-transfection with pRL-TK (<i>Renilla</i> expression vector). The mean ± SD are from three different experiments, each experiment performed in triplicate (***p < 0.001, **p < 0.01, *p < 0.05 with <i>CIP2A</i> −171/+70 compared with the control pGL4 basic vector and the mutant compared with <i>CIP2A</i> −171/+70 wild-type construct).</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="3" data-label-slug="captionless-figure"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ba/3630189/251edd122c0e/tran-3-323-g4.jpg" itemprop="contentUrl" aria-describedby="figure-caption-3" role="button" data-image-width="700" data-image-height="549" data-image-alt="captionless-figure" data-pmc-id="PMC3630189" data-figure-id="F4"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-3" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ba/3630189/1a17012ec5cd/tran-3-323-g4.gif" alt="None" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="700"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="549"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <div class="figure-caption-contents"><b> Figure 4. </b> In vitro binding of Ets1…</div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <div class="figure-caption-contents"><b> Figure 4. </b> In vitro binding of Ets1 and Elk1 to the proximal promoter region of…</div> </div> <figcaption id="figure-caption-3" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <div class="figure-caption-contents"><b>Figure 4.</b> In vitro binding of Ets1 and Elk1 to the proximal promoter region of the <i>CIP2A</i> gene. Electrophoretic mobility shift assay (EMSA) was performed with nuclear extracts (9 µg) ECC-1 cells that were incubated with the wild type (WT) probe (-138 to -107) from human <i>CIP2A</i> gene as described in Materials and Methods. In competition experiments, a 100-fold molar excess of the designated probes were utilized to demonstrate the specificity of each binding reaction. Arrows indicate the formation of specific protein–DNA complexes. The experiment was repeated twice with similar results.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="4" data-label-slug="captionless-figure"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ba/3630189/663e6c69a59d/tran-3-323-g5.jpg" itemprop="contentUrl" aria-describedby="figure-caption-4" role="button" data-image-width="700" data-image-height="838" data-image-alt="captionless-figure" data-pmc-id="PMC3630189" data-figure-id="F5"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-4" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ba/3630189/69c33dd374c0/tran-3-323-g5.gif" alt="None" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="700"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="838"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <div class="figure-caption-contents"><b> Figure 5. </b> Confirmation of Ets1 and Elk1…</div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <div class="figure-caption-contents"><b> Figure 5. </b> Confirmation of Ets1 and Elk1 binding to the proximal promoter of the <i> CIP2A… </i></div> </div> <figcaption id="figure-caption-4" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <div class="figure-caption-contents"><b>Figure 5.</b> Confirmation of Ets1 and Elk1 binding to the proximal promoter of the <i>CIP2A</i> gene. Nuclear extracts (9 μg) from ECC-1 were incubated with WT probe (−138 to−107) from the <i>CIP2A</i> gene along with 2 μg of antibody directed toward Ets1, Elk1, or Ets1 and Elk1 together. The negative control consisted of rabbit-pre-immune control IgG. The formation of DNA–protein complexes is designated by solid arrows. The experiment was repeated twice with similar results.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="5" data-label-slug="captionless-figure"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ba/3630189/ea46beb3590f/tran-3-323-g6.jpg" itemprop="contentUrl" aria-describedby="figure-caption-5" role="button" data-image-width="616" data-image-height="777" data-image-alt="captionless-figure" data-pmc-id="PMC3630189" data-figure-id="F6"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-5" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ba/3630189/7bf8b8c1d53c/tran-3-323-g6.gif" alt="None" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="616"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="777"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <div class="figure-caption-contents"><b> Figure 6. </b> ChIP analysis of Ets1 and…</div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <div class="figure-caption-contents"><b> Figure 6. </b> ChIP analysis of Ets1 and Elk1 binding to the <i> CIP2A </i> promoter. (A) Schematic…</div> </div> <figcaption id="figure-caption-5" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <div class="figure-caption-contents"><b>Figure 6.</b> ChIP analysis of Ets1 and Elk1 binding to the <i>CIP2A</i> promoter. (A) Schematic representation of the Ets1 and Elk1 binding sites within the proximal promoter region. The primers utilized for amplification of DNA region are noted in Table 3. ChIP qPCR analysis of Ets1 and Elk1 association with the <i>CIP2A</i> promoter for region 1 in (B) HeLa and (C) ECC-1 and region 2 for (D) HeLa and (E) ECC-1 are shown. Mouse IgG serves as a negative control. Region 1 is specific for the region containing the Ets1 and Elk1 binding sites in the CIP2A promoter, while region 2 is a distal part of the <i>CIP2A</i> gene that is devoid of Ets1 and Elk1 binding sites. The fold enrichment from IgG, Ets1 and Elk1 immunoprecipitation are shown and were calculated relative to input as % input. The fold change in occupancy was calculated by setting the fold enrichment of IgG to 1. The results are from two different experiments, each experiment performed in duplicate (***p < 0.001, **p < 0.01, *p < 0.05 with Ets1, Elk1 compared with the control IgG).</div> </figcaption> </figure> <figure class="figure-item tail" itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="6" data-label-slug="captionless-figure"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ba/3630189/21a90769f906/tran-3-323-g7.jpg" itemprop="contentUrl" aria-describedby="figure-caption-6" role="button" data-image-width="755" data-image-height="761" data-image-alt="captionless-figure" data-pmc-id="PMC3630189" data-figure-id="F7"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-6" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ba/3630189/c0b8dea0703a/tran-3-323-g7.gif" alt="None" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="755"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="761"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <div class="figure-caption-contents"><b> Figure 7. </b> Functional analysis of Ets1 and…</div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <div class="figure-caption-contents"><b> Figure 7. </b> Functional analysis of Ets1 and Elk1 in regulating <i> CIP2A </i> transcription in HeLa cells.…</div> </div> <figcaption id="figure-caption-6" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <div class="figure-caption-contents"><b>Figure 7.</b> Functional analysis of Ets1 and Elk1 in regulating <i>CIP2A</i> transcription in HeLa cells. Cells were transiently transfected with 100 nM of <i>ETS1</i>, <i>ELK1</i>, or <i>ETS1</i> and <i>ELK1</i> siRNA together or non-targeting siRNA (Control) as the negative control and (A) <i>ETS1</i>, (B) <i>ELK1</i> and (C) <i>CIP2A</i> mRNA expression analyzed by qRT-PCR 24 h after transfection. (D) western blot analysis of CIP2A, Ets1, Elk1 and GAPDH protein expression levels in HeLa cells tranfected with scrambled siRNA or siRNA toward <i>ETS1</i>, <i>ELK1</i> or <i>ETS1</i> and <i>ELK1</i> together after 72 h.</div> </figcaption> </figure> <figure class="figure-item tail" itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="7" data-label-slug="captionless-figure"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ba/3630189/4391216e1a9b/tran-3-323-g8.jpg" itemprop="contentUrl" aria-describedby="figure-caption-7" role="button" data-image-width="556" data-image-height="1011" data-image-alt="captionless-figure" data-pmc-id="PMC3630189" data-figure-id="F8"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-7" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ba/3630189/7db56664bb7a/tran-3-323-g8.gif" alt="None" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="556"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="1011"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <div class="figure-caption-contents"><b> Figure 8. </b> Ectopic expression of <i> ETS1 </i> and…</div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <div class="figure-caption-contents"><b> Figure 8. </b> Ectopic expression of <i> ETS1 </i> and <i> ELK1 </i> together rescues <i> CIP2A </i> expression from 3′ UTR…</div> </div> <figcaption id="figure-caption-7" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <div class="figure-caption-contents"><b>Figure 8.</b> Ectopic expression of <i>ETS1</i> and <i>ELK1</i> together rescues <i>CIP2A</i> expression from 3′ UTR siRNA treatment. HeLa cells were transiently transfected with 100 nM of <i>ETS1</i> and <i>ELK1</i> 3′ UTR siRNA together or non-targeting (NT) siRNA as the negative control. <i>ETS1</i> and <i>ELK1</i> cDNA were cloned into pCDN4-His Max Topo expression vector (Invitrogen, K864–20) utilizing the primers mentioned in Table 4, generating Ets1-Topo and Elk1-Topo. Sequences of the clones were verified and 1 µg was utilized for ectopic expression in HeLa cells following 3′ UTR siRNA treatment. Cells transfected with the empty vector served as a negative control. (A) western blot analysis of CIP2A, Ets1, Elk1 and GAPDH protein expression levels was performed 72 h after transfection and (B) qRT-PCR was conducted at 48 h after transfection to confirm rescue of CIP2A mRNA. **p < 0.01.</div> </figcaption> </figure> <figure class="figure-item tail" itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="8" data-label-slug="captionless-figure"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ba/3630189/0da2d20f21fc/tran-3-323-g9.jpg" itemprop="contentUrl" aria-describedby="figure-caption-8" role="button" data-image-width="667" data-image-height="584" data-image-alt="captionless-figure" data-pmc-id="PMC3630189" data-figure-id="F9"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-8" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01ba/3630189/1b855d8cb6fd/tran-3-323-g9.gif" alt="None" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="667"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="584"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <div class="figure-caption-contents"><b> Figure 9. </b> Analysis of CIP2A, Ets1 and…</div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <div class="figure-caption-contents"><b> Figure 9. </b> Analysis of CIP2A, Ets1 and Elk1 protein expression levels in human cervical tumor…</div> </div> <figcaption id="figure-caption-8" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <div class="figure-caption-contents"><b>Figure 9.</b> Analysis of CIP2A, Ets1 and Elk1 protein expression levels in human cervical tumor samples. Six different matched pairs of human cervical tumor samples with adjacent normal tissue were obtained and protein extracted as mentioned in Materials and Methods. Patient samples are described in Table 2. The expression levels of (A) CIP2A, (B) Elk1, (C) Ets1 and Actin (as loading control) protein were observed by western blotting.</div> </figcaption> </figure> </div> <div class="see-all actions-bar"> <button class="show-more" aria-controls="slides-container" data-ga-category="figure" data-ga-action="show_all"> All figures (9) </button> </div>  <div class="pswp figures-dialog" id="figures-dialog" tabindex="-1" role="dialog" aria-hidden="true" data-image-gallery-uid="article-figures" aria-label="Figures Dialog">  <div class="pswp__bg"></div>  <div class="pswp__scroll-wrap">  <div class="pswp__container"> <div class="pswp__item"></div> <div class="pswp__item"></div> <div class="pswp__item"></div> </div>  <div class="pswp__ui pswp__ui--hidden"> <div class="pswp__top-bar">  <div class="pswp__counter"></div> <button class="pswp__button pswp__button--close" title="Close (Esc)"></button> <button class="pswp__button pswp__button--share" title="Share"></button> <button class="pswp__button pswp__button--fs" title="Toggle fullscreen"></button> <button class="pswp__button pswp__button--zoom" title="Zoom in/out"></button>   <div class="pswp__preloader"> <div class="pswp__preloader__icn"> <div class="pswp__preloader__cut"> <div class="pswp__preloader__donut"></div> </div> </div> </div> </div> <div class="pswp__share-modal pswp__share-modal--hidden pswp__single-tap"> <div class="pswp__share-tooltip"></div> </div> <button class="pswp__button pswp__button--arrow--left" title="Previous (arrow left)"> </button> <button class="pswp__button pswp__button--arrow--right" title="Next (arrow right)"> </button> <div class="pswp__caption"> <div class="pswp__caption__center"></div> </div> </div> </div> </div> <div class="figure-dialog-caption"> <div class="figure-caption-link-container"> <a class="figure-caption-link" href="#">See this image and copyright information in PMC</a> </div> <div class="figure-caption-center" data-expand-title="click to show full caption" data-collapse-title="click to hide full caption"> </div> <button class="figure-caption-toggle-btn" aria-label="show full caption" data-expand-text="show full caption" data-collapse-text="hide full caption">  </button> </div> </div> <div class="similar-articles" id="similar"> <h2 class="title"> Similar articles </h2> <ul class="articles-list" id="similar-articles-list"> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/28027514/" ref="article_id=28027514&linksrc=similar_articles_link&ordinalpos=1" data-ga-category="similar_article" data-ga-action="28027514" data-ga-label=""> EGFR-independent Elk1/CIP2A signalling mediates apoptotic effect of an erlotinib derivative TD52 in triple-negative breast cancer cells. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Liu CY, Huang TT, Huang CT, Hu MH, Wang DS, Wang WL, Tsai WC, Lee CH, Lau KY, Yang HP, Chen MH, Shiau CW, Tseng LM, Chen KF.</span> <span class="docsum-authors short-authors">Liu CY, et al.</span> <span class="docsum-journal-citation full-journal-citation">Eur J Cancer. 2017 Feb;72:112-123. doi: 10.1016/j.ejca.2016.11.012. 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Tumor" tabindex="0" aria-controls="keyword-actions-mesh-terms-5" aria-expanded="false" data-pinger-ignore> Cell Line, Tumor </button><div id="keyword-actions-mesh-terms-5" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Cell Line, Tumor"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Cell+Line%2C+Tumor%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Cell+Line%2C+Tumor%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Cell Line, Tumor"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Cell Line, Tumor"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Cell+Line%2C+Tumor" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Cell Line, Tumor"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Cell Line, Tumor"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Cell Line, Tumor"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Endometrial Neoplasms / metabolism*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-6" aria-expanded="false" data-pinger-ignore> Endometrial Neoplasms / metabolism* </button><div id="keyword-actions-mesh-terms-major-6" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Endometrial Neoplasms / metabolism*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Endometrial+Neoplasms%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Endometrial+Neoplasms%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Endometrial Neoplasms/metabolism"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Endometrial Neoplasms / metabolism*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Endometrial+Neoplasms" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Endometrial Neoplasms / metabolism*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Endometrial Neoplasms/metabolism"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" 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class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Female" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Female"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Female"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Female"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Humans" tabindex="0" aria-controls="keyword-actions-mesh-terms-8" aria-expanded="false" data-pinger-ignore> Humans </button><div id="keyword-actions-mesh-terms-8" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Humans"><div class="title">Actions</div><div 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class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Intracellular Signaling Peptides and Proteins" tabindex="0" aria-controls="keyword-actions-mesh-terms-9" aria-expanded="false" data-pinger-ignore> Intracellular Signaling Peptides and Proteins </button><div id="keyword-actions-mesh-terms-9" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Intracellular Signaling Peptides and Proteins"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Intracellular+Signaling+Peptides+and+Proteins%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Intracellular+Signaling+Peptides+and+Proteins%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Intracellular Signaling Peptides and Proteins"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" 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Genetic" tabindex="0" aria-controls="keyword-actions-mesh-terms-13" aria-expanded="false" data-pinger-ignore> Promoter Regions, Genetic </button><div id="keyword-actions-mesh-terms-13" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Promoter Regions, Genetic"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Promoter+Regions%2C+Genetic%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Promoter+Regions%2C+Genetic%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Promoter Regions, Genetic"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Promoter Regions, Genetic"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Promoter+Regions%2C+Genetic" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Promoter Regions, Genetic"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Promoter Regions, Genetic"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Promoter Regions, Genetic"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Proto-Oncogene Mas" tabindex="0" aria-controls="keyword-actions-mesh-terms-14" aria-expanded="false" data-pinger-ignore> Proto-Oncogene Mas </button><div id="keyword-actions-mesh-terms-14" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Proto-Oncogene Mas"><div 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Mas"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Proto-Oncogene Protein c-ets-1 / genetics" tabindex="0" aria-controls="keyword-actions-mesh-terms-15" aria-expanded="false" data-pinger-ignore> Proto-Oncogene Protein c-ets-1 / genetics </button><div id="keyword-actions-mesh-terms-15" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Proto-Oncogene Protein c-ets-1 / genetics"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Proto-Oncogene+Protein+c-ets-1%2Fgenetics%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Proto-Oncogene+Protein+c-ets-1%2Fgenetics%22%5BMeSH%5D&sort=date&sort_order=desc" 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keyword-link major" aria-label="Toggle dropdown menu for keyword Proto-Oncogene Protein c-ets-1 / metabolism*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-16" aria-expanded="false" data-pinger-ignore> Proto-Oncogene Protein c-ets-1 / metabolism* </button><div id="keyword-actions-mesh-terms-major-16" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Proto-Oncogene Protein c-ets-1 / metabolism*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Proto-Oncogene+Protein+c-ets-1%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Proto-Oncogene+Protein+c-ets-1%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Proto-Oncogene Protein c-ets-1/metabolism"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Proto-Oncogene Protein c-ets-1 / metabolism*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Proto-Oncogene+Protein+c-ets-1" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Proto-Oncogene Protein c-ets-1 / metabolism*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Proto-Oncogene Protein c-ets-1/metabolism"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Proto-Oncogene Protein c-ets-1/metabolism"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Uterine Cervical Neoplasms / metabolism*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-17" aria-expanded="false" data-pinger-ignore> Uterine Cervical Neoplasms / metabolism* </button><div id="keyword-actions-mesh-terms-major-17" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Uterine Cervical Neoplasms / metabolism*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Uterine+Cervical+Neoplasms%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Uterine+Cervical+Neoplasms%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Uterine Cervical Neoplasms/metabolism"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Uterine Cervical Neoplasms / metabolism*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Uterine+Cervical+Neoplasms" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Uterine Cervical Neoplasms / metabolism*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Uterine Cervical Neoplasms/metabolism"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Uterine Cervical Neoplasms/metabolism"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword ets-Domain Protein Elk-1 / genetics" tabindex="0" aria-controls="keyword-actions-mesh-terms-18" aria-expanded="false" data-pinger-ignore> ets-Domain Protein Elk-1 / genetics </button><div id="keyword-actions-mesh-terms-18" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword ets-Domain Protein Elk-1 / genetics"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22ets-Domain+Protein+Elk-1%2Fgenetics%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22ets-Domain+Protein+Elk-1%2Fgenetics%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="ets-Domain Protein Elk-1/genetics"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="ets-Domain Protein Elk-1 / genetics"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=ets-Domain+Protein+Elk-1" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="ets-Domain Protein Elk-1 / genetics"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""ets-Domain Protein Elk-1/genetics"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""ets-Domain Protein Elk-1/genetics"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword ets-Domain Protein Elk-1 / metabolism*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-19" aria-expanded="false" data-pinger-ignore> ets-Domain Protein Elk-1 / metabolism* </button><div id="keyword-actions-mesh-terms-major-19" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword ets-Domain Protein Elk-1 / metabolism*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22ets-Domain+Protein+Elk-1%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22ets-Domain+Protein+Elk-1%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="ets-Domain Protein Elk-1/metabolism"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="ets-Domain Protein Elk-1 / metabolism*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=ets-Domain+Protein+Elk-1" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="ets-Domain Protein Elk-1 / metabolism*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""ets-Domain Protein Elk-1/metabolism"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""ets-Domain Protein 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dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Proto-Oncogene Protein c-ets-1"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Proto-Oncogene Protein c-ets-1"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword ets-Domain Protein Elk-1" tabindex="0" aria-controls="keyword-actions-substances-10" aria-expanded="false" data-pinger-ignore> ets-Domain Protein Elk-1 </button><div id="keyword-actions-substances-10" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword ets-Domain Protein Elk-1"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22ets-Domain+Protein+Elk-1%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22ets-Domain+Protein+Elk-1%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="ets-Domain Protein Elk-1"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="ets-Domain Protein Elk-1"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22ets-Domain+Protein+Elk-1%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="ets-Domain Protein Elk-1"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""ets-Domain Protein Elk-1"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""ets-Domain Protein Elk-1"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li></ul> </div> <div id="related-links" class="related-links"> <h2 class="title"> Related information </h2> <ul class="related-links-list"><li><a title="Link to related Genes" href="https://www.ncbi.nlm.nih.gov/gene?linkname=pubmed_gene&from_uid=23117818" ref="log$=recordlinks&logdbfrom=pubmed&ncbi_uid=23117818&ordinalpos=1&linkpos=1"> Gene </a></li><li><a title="Link to Gene for the GeneRIF subcategory" href="https://www.ncbi.nlm.nih.gov/gene?linkname=pubmed_gene_rif&from_uid=23117818" ref="log$=recordlinks&logdbfrom=pubmed&ncbi_uid=23117818&ordinalpos=1&linkpos=2"> Gene (GeneRIF) </a></li><li><a title="Related information in MedGen" href="https://www.ncbi.nlm.nih.gov/medgen?linkname=pubmed_medgen&from_uid=23117818" ref="log$=recordlinks&logdbfrom=pubmed&ncbi_uid=23117818&ordinalpos=1&linkpos=3"> MedGen </a></li><li><a title="Link to Protein RefSeqs" href="https://www.ncbi.nlm.nih.gov/protein?linkname=pubmed_protein_refseq&from_uid=23117818" 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Ets1 and Elk1 transcription factors regulate cancerous inhibitor of protein phosphatase 2A expression in cervical and endometrial carcinoma cells - PubMed