Clinical Utility of Salivary Cytokines for Children with Attention Deficit Hyperactivity Disorder

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Cytokines for Children with Attention Deficit Hyperactivity Disorder</title> <meta name="description" content="Clinical Utility of Salivary Cytokines for Children with Attention Deficit Hyperactivity Disorder"> <meta name="keywords" content="Cytokine, saliva, attention deficit hyperactivity disorder, child, biomarker."> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <meta name="citation_title" content="Clinical Utility of Salivary Cytokines for Children with Attention Deficit Hyperactivity Disorder"> <meta name="citation_author" content="Masaki Yamaguchi"> <meta name="citation_author" content="Daimei Sasayama"> <meta name="citation_author" content="Shinsuke Washizuka"> <meta name="citation_publication_date" content="2019/07/01"> <meta name="citation_journal_title" content="International Journal of Medical and Health Sciences"> <meta name="citation_volume" content="13"> <meta 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class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/search?q=Masaki%20Yamaguchi">Masaki Yamaguchi</a>, <a href="https://publications.waset.org/search?q=Daimei%20Sasayama"> Daimei Sasayama</a>, <a href="https://publications.waset.org/search?q=Shinsuke%20Washizuka"> Shinsuke Washizuka</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The goal of this study was to examine the possibility of salivary cytokines for the screening of attention deficit hyperactivity disorder (ADHD) in children. We carried out a case-control study, including 19 children with ADHD and 17 healthy children (controls). A multiplex bead array immunoassay was used to conduct a multi-analysis of 27 different salivary cytokines. Six salivary cytokines (interleukin (IL)-1β, IL-8, IL12p70, granulocyte colony-stimulating factor (G-CSF), interferon gamma (IFN-γ), and vascular endothelial growth factor (VEGF)) were significantly associated with the presence of ADHD (p < 0.05). An informative salivary cytokine panel was developed using VEGF by logistic regression analysis (odds ratio: 0.251). Receiver operating characteristic analysis revealed that assessment of a panel using VEGF showed “good” capability for discriminating between ADHD patients and controls (area under the curve: 0.778). ADHD has been hypothesized to be associated with reduced cerebral blood flow in the frontal cortex, due to reduced VEGF levels. Our study highlights the possibility of utilizing differential salivary cytokine levels for point-of-care testing (POCT) of biomarkers in children with ADHD. <iframe src="https://publications.waset.org/10010684.pdf" style="width:100%; height:400px;" frameborder="0"></iframe> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Cytokine" title="Cytokine">Cytokine</a>, <a href="https://publications.waset.org/search?q=saliva" title=" saliva"> saliva</a>, <a href="https://publications.waset.org/search?q=attention%20deficit%20hyperactivity%20disorder" title=" attention deficit hyperactivity disorder"> attention deficit hyperactivity disorder</a>, <a href="https://publications.waset.org/search?q=child" title=" child"> child</a>, <a href="https://publications.waset.org/search?q=biomarker." title=" biomarker."> biomarker.</a> </p> <p class="card-text"><strong>Digital Object Identifier (DOI):</strong> <a href="https://doi.org/10.5281/zenodo.3455667" target="_blank">doi.org/10.5281/zenodo.3455667</a> </p> <a href="https://publications.waset.org/10010684/clinical-utility-of-salivary-cytokines-for-children-with-attention-deficit-hyperactivity-disorder" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10010684/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10010684/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10010684/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10010684/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10010684/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10010684/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10010684/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10010684/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10010684/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10010684/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10010684.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">713</span> </span> <p class="card-text"><strong>References:</strong></p> <br>[1] G. Polanczyk, M. S.de Lima, B. L. Horta, J. Biederman, L. A. Rohde, “The Worldwide Prevalence of ADHD: a systematic review and metaregression analysis,” Am. J. Psychiatry, vol. 164, no. 6, pp. 942–948, Jun. 2007. <br>[2] R. L.Findling, “Evolution of the treatment of attention-deficit/hyperactivity disorder in children: A review,” Clin. Ther., vol. 30, no. 5, pp. 942–957, May. 2008. <br>[3] A. A. J. Verlaet, C. M. Maasakkers, N. Hermans, H. F. J. Savelkoul, “Rationale for Dietary Antioxidant Treatment of ADHD,” Nutrients, vol. 10, no. 4). pii. E405, Mar. 2018. <br>[4] A. Soltanifar, H. Massoudian, Z. Salimi, F. Moharreri, “The comparison between the levels of pro-inflammatory cytokines in ADHD children with healthy subjects,” J. Child. Adolesc. Psych., vol. 2 no. 3, pp. 3–6, Dec. 2018. <br>[5] A. H. Darwish, T. M. Elgohary, N. A. Nosair, “Serum Interleukin-6 Level in Children With Attention-Deficit Hyperactivity Disorder (ADHD),” J. Child. 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A consensus report of the WFSBP task force on biological markers and the World Federation of ADHD,” World J.Biol.Psychia., vol.13, no.5, pp.379–400, 2012. </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Account <li><a href="https://waset.org/profile">My Account</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Explore <li><a href="https://waset.org/disciplines">Disciplines</a></li> <li><a href="https://waset.org/conferences">Conferences</a></li> <li><a href="https://waset.org/conference-programs">Conference Program</a></li> <li><a href="https://waset.org/committees">Committees</a></li> <li><a href="https://publications.waset.org">Publications</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Research <li><a href="https://publications.waset.org/abstracts">Abstracts</a></li> <li><a href="https://publications.waset.org">Periodicals</a></li> <li><a href="https://publications.waset.org/archive">Archive</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Open Science <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Philosophy.pdf">Open Science Philosophy</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Award.pdf">Open Science Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Society-Open-Science-and-Open-Innovation.pdf">Open Innovation</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Postdoctoral-Fellowship-Award.pdf">Postdoctoral Fellowship Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Scholarly-Research-Review.pdf">Scholarly Research Review</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Support <li><a href="https://waset.org/page/support">Support</a></li> <li><a href="https://waset.org/profile/messages/create">Contact Us</a></li> <li><a href="https://waset.org/profile/messages/create">Report Abuse</a></li> </ul> </div> </div> </div> </div> </div> <div class="container text-center"> <hr style="margin-top:0;margin-bottom:.3rem;"> <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" class="text-muted small">Creative Commons Attribution 4.0 International License</a> <div id="copy" class="mt-2">© 2024 World Academy of Science, Engineering and Technology</div> </div> </footer> <a href="javascript:" id="return-to-top"><i class="fas fa-arrow-up"></i></a> <div class="modal" id="modal-template"> <div class="modal-dialog"> <div class="modal-content"> <div class="row m-0 mt-1"> <div class="col-md-12"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">×</span></button> </div> </div> <div class="modal-body"></div> </div> </div> </div> <script src="https://cdn.waset.org/static/plugins/jquery-3.3.1.min.js"></script> <script src="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/js/bootstrap.bundle.min.js"></script> <script src="https://cdn.waset.org/static/js/site.js?v=150220211556"></script> <script> jQuery(document).ready(function() { /*jQuery.get("https://publications.waset.org/xhr/user-menu", function (response) { jQuery('#mainNavMenu').append(response); });*/ jQuery.get({ url: "https://publications.waset.org/xhr/user-menu", cache: false }).then(function(response){ jQuery('#mainNavMenu').append(response); }); }); </script> </body> </html>

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Clinical Utility of Salivary Cytokines for Children with Attention Deficit Hyperactivity Disorder