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Expert Seminar Series - PhasAGE
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data-elementor-id="3001" class="elementor elementor-3001"> <section class="elementor-section elementor-top-section elementor-element elementor-element-1d0ad1d elementor-section-full_width elementor-section-stretched elementor-section-height-default elementor-section-height-default" data-id="1d0ad1d" data-element_type="section" data-settings="{"stretch_section":"section-stretched","background_background":"classic"}"> <div class="elementor-background-overlay"></div> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-17d0b0a" data-id="17d0b0a" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-c01d825 elementor-widget elementor-widget-heading" data-id="c01d825" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">PHASAGE </h2> </div> </div> <div class="elementor-element elementor-element-ffaf359 elementor-widget elementor-widget-heading" data-id="ffaf359" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default"><p>PhasAGE – Excellence Hub on <strong>Phase Transitions</strong> in <strong>Aging</strong> and <strong>Age-Related Disorders</strong></p></h2> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-9d83d07 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="9d83d07" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-77178ea" data-id="77178ea" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-ec8ffc0 elementor-widget elementor-widget-heading" data-id="ec8ffc0" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">EXPERT SEMINAR SERIES </h2> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-f16cd22 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="f16cd22" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0ad3c45" data-id="0ad3c45" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element 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class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a5d294d" data-id="a5d294d" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-441c0e5 elementor-widget elementor-widget-heading" data-id="441c0e5" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">19 October 2023 | Instituto de Investigação e Inovação em Saúde (i3S)</h2> </div> </div> <div class="elementor-element elementor-element-354323a elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor" data-id="354323a" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong>The seminar was co-hosted with the <a href="https://phasage.eu/pt/iii-phasage-international-conference/">III PhasAGE International Conference</a>.</strong></p> </div> </div> <div class="elementor-element elementor-element-934769c elementor-widget elementor-widget-spacer" data-id="934769c" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> <section class="elementor-section elementor-inner-section elementor-element elementor-element-4765d3c elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="4765d3c" data-element_type="section"> <div class="elementor-container elementor-column-gap-narrow"> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-2853ddf" data-id="2853ddf" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-bbd3afa elementor-widget elementor-widget-image" data-id="bbd3afa" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img decoding="async" src="https://phasage.eu/wp-content/uploads/elementor/thumbs/Salvador-Ventura-p2o21ygg6x9tvr6o6nj81hdgjwkem5d2f4suz4lzt4.jpg" title="Salvador Ventura" alt="" loading="lazy" /> </div> </div> </div> </div> <div class="elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-b0ddba4" data-id="b0ddba4" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-f962a1e elementor-widget elementor-widget-text-editor" data-id="f962a1e" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Natural and Synthetic Prion-like Domains: Functions and Applications</p> </div> </div> <div class="elementor-element elementor-element-ae7b8bc elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor" data-id="ae7b8bc" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><a href="https://ibb.uab.cat/wp-content/themes/viral/modules/ibb_membres/view_grup.php?CodiGrup=36" target="_blank" rel="noopener">Salvador Ventura</a></p> </div> </div> <div class="elementor-element elementor-element-4b870f9 elementor-widget__width-initial elementor-widget elementor-widget-text-editor" data-id="4b870f9" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Amyloid assemblies are primarily recognized for their pathological implications in neurodegenerative diseases. Nevertheless, their inherent characteristics, including modularity, hierarchical assembly, mechanical properties, and environmental stability, offer significant potential for diverse functional applications. Here we describe how our comprehension of the sequential determinants of amyloid assembly has facilitated the development of novel nanomaterials with catalytic, biosensing, virus-neutralizing, cell recognizing and cell activating functionalities.</p> </div> </div> <div class="elementor-element elementor-element-cccc822 elementor-widget elementor-widget-text-editor" data-id="cccc822" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><em>Host: Sandra Ribeiro (IBMC/i3S)</em></strong></p> </div> </div> </div> </div> </div> </section> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-45cef52 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="45cef52" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f4f0d7a" data-id="f4f0d7a" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-ed9078b elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="ed9078b" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <div class="elementor-divider"> <span class="elementor-divider-separator"> </span> </div> </div> </div> <div class="elementor-element elementor-element-f97fcbc elementor-widget elementor-widget-spacer" data-id="f97fcbc" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-a99a3c5 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="a99a3c5" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-78a41c1" data-id="78a41c1" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-3f7ac5d elementor-widget elementor-widget-heading" data-id="3f7ac5d" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">11 September 2023 | University of Padova (UniPD)</h2> </div> </div> <div class="elementor-element elementor-element-b1130d7 elementor-widget elementor-widget-spacer" data-id="b1130d7" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> <section class="elementor-section elementor-inner-section elementor-element elementor-element-5cb2cbb elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="5cb2cbb" data-element_type="section"> <div class="elementor-container elementor-column-gap-narrow"> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-e23ae01" data-id="e23ae01" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-44fa512 elementor-widget elementor-widget-image" data-id="44fa512" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img decoding="async" src="https://phasage.eu/wp-content/uploads/elementor/thumbs/Pedro_Pereira-p4jxfatcq7ssh34seatczryatkjvmconysghlm2z60.png" title="Pedro_Pereira" alt="" loading="lazy" /> </div> </div> </div> </div> <div class="elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-c956235" data-id="c956235" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-0692969 elementor-widget elementor-widget-text-editor" data-id="0692969" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Flexible, decorated and tight – a new breed of peptide anticoagulants</p> </div> </div> <div class="elementor-element elementor-element-dc3b381 elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor" data-id="dc3b381" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><a href="https://www.i3s.up.pt/personal-info.php?id=508&idg=92" target="_blank" rel="noopener">Pedro Pereira</a></p> </div> </div> <div class="elementor-element elementor-element-9ce5bd5 elementor-widget elementor-widget-text-editor" data-id="9ce5bd5" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><em>Host: Silvio Tosatto (UniPD)</em></strong></p> </div> </div> </div> </div> </div> </section> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-ade97a5 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="ade97a5" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-952b1c1" data-id="952b1c1" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-f42a519 elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="f42a519" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <div class="elementor-divider"> <span class="elementor-divider-separator"> </span> </div> </div> </div> <div class="elementor-element elementor-element-3bc622b elementor-widget elementor-widget-spacer" data-id="3bc622b" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-833eb37 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="833eb37" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-65a4f39" data-id="65a4f39" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-61c19e2 elementor-widget elementor-widget-heading" data-id="61c19e2" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">23 May 2023 | University of Padova (UniPD)</h2> </div> </div> <div class="elementor-element elementor-element-7b5cd4b elementor-widget elementor-widget-spacer" data-id="7b5cd4b" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> <section class="elementor-section elementor-inner-section elementor-element elementor-element-c7b829b elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="c7b829b" data-element_type="section"> <div class="elementor-container elementor-column-gap-narrow"> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-54783bd" data-id="54783bd" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-8b54ea0 elementor-widget elementor-widget-image" data-id="8b54ea0" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img decoding="async" src="https://phasage.eu/wp-content/uploads/elementor/thumbs/Sandra-Ribeiro-scaled-p2o1irl2np2x5brmx8aqacvpuxemu229rks5djp47c.jpg" title="Sandra Ribeiro" alt="" loading="lazy" /> </div> </div> </div> </div> <div class="elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-30aff07" data-id="30aff07" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-339cf0b elementor-widget elementor-widget-text-editor" data-id="339cf0b" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Breaking the aggregation chain with small molecule inhibitors: a path for Spinocerebellar Ataxia type 3 therapies</p> </div> </div> <div class="elementor-element elementor-element-7c6970f elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor" data-id="7c6970f" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><a href="https://www.i3s.up.pt/personal-info.php?id=507&idg=7" target="_blank" rel="noopener">Sandra Ribeiro</a></p><p> </p> </div> </div> <div class="elementor-element elementor-element-b2b6d95 elementor-widget elementor-widget-text-editor" data-id="b2b6d95" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><em>Host: Silvio Tosatto (UniPD)</em></strong></p> </div> </div> </div> </div> </div> </section> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-74be04e elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="74be04e" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ea9e8fb" data-id="ea9e8fb" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-17e3827 elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="17e3827" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <div class="elementor-divider"> <span class="elementor-divider-separator"> </span> </div> </div> </div> <div class="elementor-element elementor-element-27aed7b elementor-widget elementor-widget-spacer" data-id="27aed7b" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-af00ae6 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="af00ae6" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-40f5b2e" data-id="40f5b2e" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-c17f705 elementor-widget elementor-widget-heading" data-id="c17f705" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">27 April 2023 | Vrije Universiteit Brussel (VUB-VIB)</h2> </div> </div> <div class="elementor-element elementor-element-e036fac elementor-widget elementor-widget-spacer" data-id="e036fac" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> <section class="elementor-section elementor-inner-section elementor-element elementor-element-056d264 elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="056d264" data-element_type="section"> <div class="elementor-container elementor-column-gap-narrow"> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-06d0c7c" data-id="06d0c7c" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-8190390 elementor-widget elementor-widget-image" data-id="8190390" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img decoding="async" src="https://phasage.eu/wp-content/uploads/elementor/thumbs/Pedro-Martins-1-p4jyt5794y164oqcccg5pp58u4vksjk95huequ6f7s.jpg" title="Pedro Martins" alt="" loading="lazy" /> </div> </div> </div> </div> <div class="elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-82329a0" data-id="82329a0" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-3e10b07 elementor-widget elementor-widget-text-editor" data-id="3e10b07" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>NAGpkin: a new web tool for seamless quantification of Nucleation-And-Growth KINetics of Protein phase separation</p> </div> </div> <div class="elementor-element elementor-element-8d0fcc6 elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor" data-id="8d0fcc6" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><a href="https://www.i3s.up.pt/personal-info.php?id=1952&idg=7" target="_blank" rel="noopener">Pedro Martins</a></p> </div> </div> <div class="elementor-element elementor-element-39c217c elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor" data-id="39c217c" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <div class="ekit-team-modal-content"><p>NAGpkin (beta version) is a free web tool for characterizing the mechanisms of protein phase separation. Protein phase separation is relevant in both health and disease in phenomena such as the liquid-liquid phase separation of functional droplets, or the self-assembly of proteins into solid aggregates called amyloids. Raw data describing the formation of a new protein phase is analyzed to quantify the relative importance of the kinetic steps of primary nucleation, secondary nucleation and growth. Information about the possible occurrence of Off-Pathway Aggregation, Surface Tension Effects and coalescence is also provided.</p></div> </div> </div> <div class="elementor-element elementor-element-02c9c4d elementor-widget elementor-widget-text-editor" data-id="02c9c4d" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><em>Host: Peter Tompa (VIB)</em></strong></p> </div> </div> </div> </div> </div> </section> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-171d9b4 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="171d9b4" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-099e3a0" data-id="099e3a0" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-bce3294 elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="bce3294" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <div class="elementor-divider"> <span class="elementor-divider-separator"> </span> </div> </div> </div> <div class="elementor-element elementor-element-ff81449 elementor-widget elementor-widget-spacer" data-id="ff81449" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-1d4287f elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="1d4287f" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2cfd8b7" data-id="2cfd8b7" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-5a1676d elementor-widget elementor-widget-heading" data-id="5a1676d" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">28 March 2023 | Instituto de Investigação e Inovação em Saúde (i3S)</h2> </div> </div> <div class="elementor-element elementor-element-e1f3e72 elementor-widget elementor-widget-spacer" data-id="e1f3e72" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> <section class="elementor-section elementor-inner-section elementor-element elementor-element-1bd7ff4 elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="1bd7ff4" data-element_type="section"> <div class="elementor-container elementor-column-gap-narrow"> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-ad4916a" data-id="ad4916a" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-9c73325 elementor-widget elementor-widget-image" data-id="9c73325" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img decoding="async" src="https://phasage.eu/wp-content/uploads/elementor/thumbs/IMG_20190921_090659-q2x107ryeqi6zk5dxaor5f6x6gzq32s9ajmdehhk08.jpg" title="fbt" alt="" loading="lazy" /> </div> </div> </div> </div> <div class="elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-9114f94" data-id="9114f94" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-f3c637f elementor-widget elementor-widget-text-editor" data-id="f3c637f" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>The contribution of IDR in Neurodevelopmental Disorders</p><p> </p> </div> </div> <div class="elementor-element elementor-element-44523c4 elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor" data-id="44523c4" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><a href="https://biocomputingup.it/" target="_blank" rel="noopener">Emanuela Leonardi</a></p><p> </p> </div> </div> <div class="elementor-element elementor-element-c459b4e elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor" data-id="c459b4e" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <div class="ekit-team-modal-content"><div><p>Neurodevelopmental Disorders (NDDs) are impairments of the growth and development of the brain and the central nervous system. The most common NDDs include autism spectrum disorders (ASD) and attention Deficit disorder (ADHD), and intellectual disability. Next-generation sequencing studies have revealed the major impact of <em>de novo</em> variants (DNVs) in NDDs. However, a substantial fraction of these DNVs are frequently disregarded and remain of uncertain significance, in particular the missense variants mapping in intrinsically disordered regions (IDRs) acting via non-haploinsufficient mechanisms. By means of computational tools, we investigated the effects of variants located in IDRs identified in a subset of high confidence NDDs-associated genes. The impact of the variants was estimated considering IDRs-specific feature, including the various classes of functional linear motifs and the phase-separation-promoting features.</p></div></div> </div> </div> </div> </div> </div> </section> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-fac4cab elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="fac4cab" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-bf0cbac" data-id="bf0cbac" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-2df990d elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="2df990d" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <div class="elementor-divider"> <span class="elementor-divider-separator"> </span> </div> </div> </div> <div class="elementor-element elementor-element-4a2273b elementor-widget elementor-widget-spacer" data-id="4a2273b" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-7d5effd elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="7d5effd" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-06d9d0d" data-id="06d9d0d" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-b46504b elementor-widget elementor-widget-heading" data-id="b46504b" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">12 December 2022 | Vrije Universiteit Brussel (VUB-VIB)</h2> </div> </div> <div class="elementor-element elementor-element-126f434 elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor" data-id="126f434" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong>The seminar was co-hosted with the <a href="https://phasage.eu/ii-phasage-international-conference/">PhasAGE-VIB International Conference</a>. </strong></p> </div> </div> <div class="elementor-element elementor-element-5c3463f elementor-widget elementor-widget-spacer" data-id="5c3463f" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> <section class="elementor-section elementor-inner-section elementor-element elementor-element-f51d117 elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="f51d117" data-element_type="section"> <div class="elementor-container elementor-column-gap-narrow"> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-31e8af3" data-id="31e8af3" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-edfeda5 elementor-widget elementor-widget-image" data-id="edfeda5" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img decoding="async" src="https://phasage.eu/wp-content/uploads/elementor/thumbs/Sandra-Ribeiro-scaled-p2o1irl2np02ud278uwfmtpnxp5mgm6cs5az8r2cug.jpg" title="Sandra Ribeiro" alt="" loading="lazy" /> </div> </div> </div> </div> <div class="elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-10b19b9" data-id="10b19b9" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-b967d08 elementor-widget elementor-widget-text-editor" data-id="b967d08" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Ataxin-3 self-assembly inhibitors: opportunities and challenges for Spinocerebellar Ataxia Type 3 therapies</p><p> </p> </div> </div> <div class="elementor-element elementor-element-5766fff elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor" data-id="5766fff" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><a href="https://www.i3s.up.pt/personal-info.php?id=507&idg=7" target="_blank" rel="noopener">Sandra Ribeiro</a></p><p> </p> </div> </div> <div class="elementor-element elementor-element-cd8e904 elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor" data-id="cd8e904" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <div class="ekit-team-modal-content"><div>Spinocerebellar ataxia type 3 (SCA3) is caused by the expansion of CAG repeats encoding polyglutamine tracts in the gene ATXN3. This rare form of ataxia leads to progressive cerebellar dysfunction and its pathogenesis involves the aggregation of the mutant ataxin-3 protein. Ataxin-3 is a modular protein, composed of a globular Josephin (JD) and a flexible C-terminal tail containing the polyQ tract. Both normal and pathogenic ataxin-3 assemble in vitro into amyloid-like structures primed by the aggregation-prone region in JD, but only the polyQ expansion elicits the formation of mature and SDS-resistant fibrils. Intracellular aggregates, enriched in the mutant ataxin-3 have been identified in SCA3 patients’ affected brain regions, such as the cerebellum, brain stem, substantia nigra, striatum, and spinal cord. While the precise neurotoxic species is widely debated, increasing evidence shows that the<br />ataxin-3 aggregation process itself contributes to the underlying neurodegeneration. Therefore, addressing pathogenic ataxin-3 aggregation represents a promising approach for developing disease-modifying treatments for SCA3. I will show how we are combining in silico, in vitro, in situ, and in vivo studies to study molecules with anti-ataxin-3 aggregation properties. In particular, I will show data on a small molecule that delays ataxin-3 assembly into amyloid fibrils by stabilizing its monomeric state and modifying its aggregation kinetics. This molecule has a clear potential as a disease-modifying therapy for SCA3 as it was able to alleviate motor deficits of the SCA3 C. elegans model and early symptomatic treatment also delayed disease installation and significantly improved motor behavior of a SCA3 transgenic mouse model.</div></div> </div> </div> <div class="elementor-element elementor-element-46b767b elementor-widget elementor-widget-text-editor" data-id="46b767b" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><em>Host: Peter Tompa (VIB)</em></strong></p> </div> </div> </div> </div> </div> </section> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-be2c79c elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="be2c79c" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-43fc552" data-id="43fc552" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-6b07a12 elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="6b07a12" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <div class="elementor-divider"> <span class="elementor-divider-separator"> </span> </div> </div> </div> <div class="elementor-element elementor-element-dded83e elementor-widget elementor-widget-spacer" data-id="dded83e" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-10cb28d elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="10cb28d" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-70eb9f5" data-id="70eb9f5" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-7fe70c3 elementor-widget elementor-widget-heading" data-id="7fe70c3" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">4 November 2022 | Autonomous Universtity of Barcelona (UAB)</h2> </div> </div> <div class="elementor-element elementor-element-69cbbc3 elementor-widget elementor-widget-spacer" data-id="69cbbc3" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> <section class="elementor-section elementor-inner-section elementor-element elementor-element-2e90d9d elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="2e90d9d" data-element_type="section"> <div class="elementor-container elementor-column-gap-narrow"> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-8de6459" data-id="8de6459" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-5fca35f elementor-widget elementor-widget-image" data-id="5fca35f" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img decoding="async" src="https://phasage.eu/wp-content/uploads/elementor/thumbs/Reto-Gassmann-2-p305rl5a77pv1gxk4cqeernwkq3ax387bsmbfddcaw.png" title="Reto Gassmann 2" alt="" loading="lazy" /> </div> </div> </div> </div> <div class="elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-7dcd7f5" data-id="7dcd7f5" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-4c8c44d elementor-widget elementor-widget-text-editor" data-id="4c8c44d" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Regulation of neuronal organelle transport by the scaffolding protein JIP3</p> </div> </div> <div class="elementor-element elementor-element-624a5ea elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor" data-id="624a5ea" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><a href="https://www.i3s.up.pt/personal-info.php?id=496&idg=12" target="_blank" rel="noopener">Reto Gassmann</a></p> </div> </div> <div class="elementor-element elementor-element-2e76e40 elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor" data-id="2e76e40" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <div class="ekit-team-modal-content"><div><div><div>Neurodegenerative diseases illustrate the critical role of microtubule-based transport in highly polarized cells. The opposite-polarity motors dynein and kinesin-1 are recruited to their cargo by multiple adaptor protein families, which also couple recruitment to activation of motility. We use biochemical approaches and genome engineering in the roundworm <em>C. elegans</em> to gain insight into the underlying molecular mechanisms. The seminar will cover our recent structure-function analysis of the conserved scaffolding protein JIP3, which interacts with either motor and regulates organelle as well as vesicle transport.</div></div></div><div> </div></div> </div> </div> <div class="elementor-element elementor-element-4aa3380 elementor-widget elementor-widget-text-editor" data-id="4aa3380" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><em>Host: Salvador Ventura (UAB)</em></strong></p> </div> </div> </div> </div> </div> </section> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-5152d29 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="5152d29" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-871ca22" data-id="871ca22" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-5facd51 elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="5facd51" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <div class="elementor-divider"> <span class="elementor-divider-separator"> </span> </div> </div> </div> <div class="elementor-element elementor-element-c10a8c3 elementor-widget elementor-widget-spacer" data-id="c10a8c3" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-9473396 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="9473396" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-544caf0" data-id="544caf0" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-4507a16 elementor-widget elementor-widget-heading" data-id="4507a16" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">14 October 2022 | Instituto de Investigação e Inovação em Saúde (i3S)</h2> </div> </div> <div class="elementor-element elementor-element-f5921ce elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor" data-id="f5921ce" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong>The seminar was co-hosted with the <a href="https://www.i3s.up.pt/seminars.php" target="_blank" rel="noopener">i3S Friday Noon Seminar Series</a>. </strong></p> </div> </div> <div class="elementor-element elementor-element-afd7fc3 elementor-widget elementor-widget-spacer" data-id="afd7fc3" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> <section class="elementor-section elementor-inner-section elementor-element elementor-element-bd8745c elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="bd8745c" data-element_type="section"> <div class="elementor-container elementor-column-gap-narrow"> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-1b76f41" data-id="1b76f41" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-b130982 elementor-widget elementor-widget-image" data-id="b130982" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img decoding="async" src="https://phasage.eu/wp-content/uploads/elementor/thumbs/Silvio-Tosatto-p2o1kgokzxek3zaw0gphafgogz1hqdstnz6pkj6iyw.jpg" title="Silvio Tosatto" alt="" loading="lazy" /> </div> </div> </div> </div> <div class="elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-d620d8f" data-id="d620d8f" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-a12f298 elementor-widget elementor-widget-text-editor" data-id="a12f298" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Intrinsic Protein Disorder and Conditional Folding in AlphaFoldDB</p> </div> </div> <div class="elementor-element elementor-element-7795620 elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor" data-id="7795620" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><a href="https://biocomputingup.it/" target="_blank" rel="noopener">Silvio Tosatto</a></p> </div> </div> <div class="elementor-element elementor-element-39f90dd elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor" data-id="39f90dd" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <div class="ekit-team-modal-content">Intrinsically disordered regions (IDRs) defying the traditional protein structure-function paradigm have been difficult to analyze. The<br />availability of accurate structure predictions on a large scale in AlphaFoldDB offers a fresh perspective on IDR prediction. Here we<br />establish three baselines for IDR prediction from AlphaFoldDB models based on the recent Critical Assessment of Intrinsic Protein Disorder (CAID; Necci et al., Nat. Meth. 2021) dataset. Surprisingly, AlphaFoldDB is highly competitive for predicting both IDRs and conditionally folded binding regions, demonstrating the plasticity of the disorder to structure continuum.</div> </div> </div> <div class="elementor-element elementor-element-f9dfd56 elementor-widget elementor-widget-text-editor" data-id="f9dfd56" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><em>Host: Sandra Ribeiro (IBMC/i3S)</em></strong></p> </div> </div> </div> </div> </div> </section> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-d308b3b elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="d308b3b" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-281bdb8" data-id="281bdb8" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-5c75254 elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="5c75254" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <div class="elementor-divider"> <span class="elementor-divider-separator"> </span> </div> </div> </div> <div class="elementor-element elementor-element-5fb5985 elementor-widget elementor-widget-spacer" data-id="5fb5985" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-a802f7d elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="a802f7d" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-10a14be" data-id="10a14be" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-4796d3f elementor-widget elementor-widget-heading" data-id="4796d3f" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">22 April 2022 | Instituto de Investigação e Inovação em Saúde (i3S)</h2> </div> </div> <div class="elementor-element elementor-element-461b7af elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor" data-id="461b7af" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong>The seminar was co-hosted with the <a href="https://www.i3s.up.pt/seminars.php" target="_blank" rel="noopener">i3S Friday Noon Seminar Series</a>. </strong></p> </div> </div> <div class="elementor-element elementor-element-46082ae elementor-widget elementor-widget-spacer" data-id="46082ae" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> <section class="elementor-section elementor-inner-section elementor-element elementor-element-41144e8 elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="41144e8" data-element_type="section"> <div class="elementor-container elementor-column-gap-narrow"> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-feb577f" data-id="feb577f" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-0510217 elementor-widget elementor-widget-image" data-id="0510217" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img decoding="async" src="https://phasage.eu/wp-content/uploads/elementor/thumbs/VIB3_Ludo-Van-Den-Bosch-7-scaled-e1651078486564-pnzo6t1im51ronhd3rp05x4f2y1kzntnc792kwlaiw.jpg" title="VIB3_Ludo Van Den Bosch-7" alt="" loading="lazy" /> </div> </div> </div> </div> <div class="elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-0f4a6de" data-id="0f4a6de" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-ef2529c elementor-widget elementor-widget-text-editor" data-id="ef2529c" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong>Liquid-liquid phase separation and stress granule dynamics in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD): challenges and future perspectives</strong></p> </div> </div> <div class="elementor-element elementor-element-e75efc0 elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor" data-id="e75efc0" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><a href="https://cbd.vib.be/labs/van-den-bosch-lab" target="_blank" rel="noopener">Ludo Van Den Bosch</a></p> </div> </div> <div class="elementor-element elementor-element-105f163 elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor" data-id="105f163" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <div class="ekit-team-modal-content">The focus of his research is on motor neuron diseases such as amyotrophic lateral sclerosis (ALS), as well as on different neuropathies such as Charcot-Marie-Tooth disease (CMT). The central goal of his research is to understand more in detail the mechanisms of neuronal and axonal degeneration and regeneration and to translate these discoveries into new therapeutic strategies for the different neurodegenerative disorders. Research models range from cell lines, induced pluripotent stem cells (iPSCs) and small animal models including fruit fly and zebrafish to transgenic mouse models for the different neurodegenerative diseases. The main research focus is on the importance of disturbances in intracellular transport processes, including phase separation and the formation of stress granules as well as nucleocytoplasmic and axonal transport. In addition, the role of mutated proteins such as FUS and TDP-43 in these processes is investigated in detail.</div> </div> </div> <div class="elementor-element elementor-element-7e87a12 elementor-widget elementor-widget-text-editor" data-id="7e87a12" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><em>Host: Sandra Ribeiro (IBMC/i3S)</em></strong></p> </div> </div> </div> </div> </div> </section> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-5a48146 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="5a48146" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c08fc16" data-id="c08fc16" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-4a749fa elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="4a749fa" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <div class="elementor-divider"> <span class="elementor-divider-separator"> </span> </div> </div> </div> <div class="elementor-element elementor-element-aef01e4 elementor-widget elementor-widget-spacer" data-id="aef01e4" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-185a058 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="185a058" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d20dcce" data-id="d20dcce" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-7a9a175 elementor-widget elementor-widget-heading" data-id="7a9a175" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">3 December 2021 | Instituto de Investigação e Inovação em Saúde (i3S)</h2> </div> </div> <div class="elementor-element elementor-element-538a840 elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor" data-id="538a840" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong>The seminar was co-hosted with the <a href="https://www.i3s.up.pt/seminars.php" target="_blank" rel="noopener">i3S Friday Noon Seminar Series.</a></strong></p> </div> </div> <div class="elementor-element elementor-element-6ff7ba4 elementor-widget elementor-widget-spacer" data-id="6ff7ba4" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> <section class="elementor-section elementor-inner-section elementor-element elementor-element-7b3da572 elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="7b3da572" data-element_type="section"> <div class="elementor-container elementor-column-gap-narrow"> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-5196265c" data-id="5196265c" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-7e44bc37 elementor-widget elementor-widget-image" data-id="7e44bc37" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img decoding="async" src="https://phasage.eu/wp-content/uploads/elementor/thumbs/Salvador-Ventura-p2o21ygg6x9tvr6o6nj81hdgjwkem5d2f4suz4lzt4.jpg" title="Salvador Ventura" alt="" loading="lazy" /> </div> </div> </div> </div> <div class="elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-73d15d0f" data-id="73d15d0f" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-3503f8b8 elementor-widget elementor-widget-text-editor" data-id="3503f8b8" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Natural and Synthetic Prion-like Domains: Functions and Applications</p> </div> </div> <div class="elementor-element elementor-element-65a4cda3 elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor" data-id="65a4cda3" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><a href="https://ibb.uab.cat/wp-content/themes/viral/modules/ibb_membres/view_grup.php?CodiGrup=36" target="_blank" rel="noopener">Salvador Ventura</a></p> </div> </div> <div class="elementor-element elementor-element-167ce61c elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor" data-id="167ce61c" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <div class="ekit-team-modal-content">Salvador Ventura’s lab uses a multidisciplinary approach to address fundamental aspects of protein folding, misfolding and aggregation. In addition, to define the basic mechanistic principles underlying these processes, his research team aims to understand how their deregulation leads to the onset of human conformational diseases and to develop innovative therapeutics to target these pathologies. Moreover, this knowledge allow the research team to design and produce novel and better protein-based biopharmaceuticals as well as the development of new self-assembled materials for nanotechnology applications.</div> </div> </div> <div class="elementor-element elementor-element-35431727 elementor-widget__width-initial elementor-widget elementor-widget-text-editor" data-id="35431727" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Talk Summary</p> </div> </div> <div class="elementor-element elementor-element-3bef6719 elementor-widget__width-initial elementor-widget elementor-widget-text-editor" data-id="3bef6719" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Amyloid fibrils are most known because of their association with disease. However, nature also exploits amyloid structures for functional purposes, and, indeed, researchers have used the unique molecular architecture of amyloids to build up different materials. Prions are a particular set of amyloids that can switch between a soluble conformation and an amyloid state. This ability usually relies on a disordered and low-complexity region known as the Prion Domain. Originally thought to be restricted to yeast, functional prion-like proteins displaying these sequences have also been identified in other organisms. Here we describe how a natural Prion-like Domain (PrLD) has evolved to substitute for the function of extracellular globular domains in bacteria and demonstrate how the particular properties of this kind of sequences can be employed to design synthetic PrLDs able to self-assemble into novel functional nanomaterials.</p> </div> </div> <div class="elementor-element elementor-element-bb37b82 elementor-widget elementor-widget-text-editor" data-id="bb37b82" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><em>Host: Sandra Ribeiro (IBMC/i3S)</em></strong></p> </div> </div> </div> </div> </div> </section> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-f034d96 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="f034d96" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5e63668" data-id="5e63668" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-50fb07f elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="50fb07f" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <div class="elementor-divider"> <span class="elementor-divider-separator"> </span> </div> </div> </div> <div class="elementor-element elementor-element-e819d36 elementor-widget elementor-widget-spacer" data-id="e819d36" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-e987e01 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="e987e01" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6bab147" data-id="6bab147" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-1ba2833 elementor-widget elementor-widget-heading" data-id="1ba2833" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">15 November 2021 | ONLINE EVENT</h2> </div> </div> <div class="elementor-element elementor-element-aded1bb elementor-widget elementor-widget-spacer" data-id="aded1bb" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> <section class="elementor-section elementor-inner-section elementor-element elementor-element-1738034 elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="1738034" data-element_type="section"> <div class="elementor-container elementor-column-gap-narrow"> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-90af945" data-id="90af945" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-074dc90 elementor-widget elementor-widget-image" data-id="074dc90" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img decoding="async" src="https://phasage.eu/wp-content/uploads/elementor/thumbs/Reto-Gassmann-2-p305rl5a77pv1gxk4cqeernwkq3ax387bsmbfddcaw.png" title="Reto Gassmann 2" alt="" loading="lazy" /> </div> </div> </div> </div> <div class="elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-fb6a8ad" data-id="fb6a8ad" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-d51e505 elementor-widget elementor-widget-text-editor" data-id="d51e505" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Dissecting the contribution of motor-cargo adaptors to microtubule-based transport in neurons</p> </div> </div> <div class="elementor-element elementor-element-8ca9974 elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor" data-id="8ca9974" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><a href="https://www.i3s.up.pt/personal-info.php?id=496&idg=12" target="_blank" rel="noopener">Reto Gassmann </a></p> </div> </div> <div class="elementor-element elementor-element-8badd5a elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor" data-id="8badd5a" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Reto Gassmann is a group leader at the Institute for Research and Innovation in Health (i3S) in Porto interested in cell division and microtubule-based intracellular transport. His group uses live-cell fluorescence microscopy, genetics, and biochemical approaches in the nematode <em>Caenorhabditis elegans</em> and human cultured cells to study the function and regulation of cytoplasmic dynein 1, the major microtubule minus end-directed motor in animal cells.</p> </div> </div> <div class="elementor-element elementor-element-902bcf2 elementor-widget__width-initial elementor-widget elementor-widget-text-editor" data-id="902bcf2" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Talk Summary</p> </div> </div> <div class="elementor-element elementor-element-e08e85f elementor-widget__width-initial elementor-widget elementor-widget-text-editor" data-id="e08e85f" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Long-rage intracellular transport of vesicles and organelles by microtubule-based motors is critical for the development, survival, and function of neurons. A central unanswered question is how the microtubule minus end-directed motor cytoplasmic dynein 1 (dynein) and plus end-directed kinesins work together to set up useful bi-directional transport systems. To gain insight into the underlying regulatory mechanisms<em>, </em>our approach is to generate and characterize separation-of-function mutations that disrupt specific protein-protein interactions between motors and their cargo adaptors. I will present our recent work on the conserved MAP kinase scaffold JIP3, which suggests that JIP3 uses its interaction with dynein and kinesin-1 to drive bi-directional transport of endo-lysosomal organelles in <em>C. elegans</em> touch receptor neurons.</p> </div> </div> <div class="elementor-element elementor-element-5606924 elementor-widget elementor-widget-text-editor" data-id="5606924" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><em>Chair: Valérie Bercier (<b>VIB-KU Leuven</b>)</em></strong></p> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-inner-section elementor-element elementor-element-76aa7a1 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="76aa7a1" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-110cb7e" data-id="110cb7e" data-element_type="column"> <div class="elementor-widget-wrap"> </div> </div> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-dd498b7" data-id="dd498b7" data-element_type="column"> <div class="elementor-widget-wrap"> </div> </div> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-b0b2b9e" data-id="b0b2b9e" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-1cc1ec6 elementor-widget elementor-widget-button" data-id="1cc1ec6" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-xs" href="https://youtu.be/CXVs5gNQ6gk" target="_blank" rel="noopener"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-text">Webinar</span> </span> </a> </div> </div> </div> </div> </div> </div> </section> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-2a347e6 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="2a347e6" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-84f892f" data-id="84f892f" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-95015e7 elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="95015e7" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <div class="elementor-divider"> <span class="elementor-divider-separator"> </span> </div> </div> </div> <div class="elementor-element elementor-element-47f2b23 elementor-widget elementor-widget-spacer" data-id="47f2b23" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-696bc91 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="696bc91" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-fbde162" data-id="fbde162" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-e4ba20e elementor-widget elementor-widget-heading" data-id="e4ba20e" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">14 June 2021 | ONLINE EVENT</h2> </div> </div> <div class="elementor-element elementor-element-daad3f8 elementor-widget elementor-widget-spacer" data-id="daad3f8" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> <section class="elementor-section elementor-inner-section elementor-element elementor-element-8522417 elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="8522417" data-element_type="section"> <div class="elementor-container elementor-column-gap-narrow"> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-53aed81" data-id="53aed81" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-9ec7064 elementor-widget elementor-widget-image" data-id="9ec7064" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img decoding="async" src="https://phasage.eu/wp-content/uploads/elementor/thumbs/Elsa-Logarinho-2-p305rj9ltjnae90afbx59s4zdyckhp0qnjbcgtg4nc.png" title="Elsa Logarinho 2" alt="" loading="lazy" /> </div> </div> <div class="elementor-element elementor-element-c9f9ee3 elementor-widget elementor-widget-image" data-id="c9f9ee3" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img decoding="async" src="https://phasage.eu/wp-content/uploads/2021/04/Elsa-Logarinho-2.jpg" title="" alt="" loading="lazy" /> </div> </div> </div> </div> <div class="elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-8bd01c2" data-id="8bd01c2" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-e5d3a14 elementor-widget elementor-widget-text-editor" data-id="e5d3a14" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong>Inhibition of age-associated genomic instability: emerging strategy to delay cellular senescence and aging</strong></p> </div> </div> <div class="elementor-element elementor-element-6df8612 elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor" data-id="6df8612" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><a href="https://www.i3s.up.pt/personal-info.php?id=64&idg=105" target="_blank" rel="noopener">Elsa Logarinho</a></p> </div> </div> <div class="elementor-element elementor-element-d1b7b63 elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor" data-id="d1b7b63" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p style="font-weight: 400;">Since 2015 E. Logarinho (EL) leads the Aging & Aneuploidy group, dedicated to high-profile research on the mechanisms of cell cycle deregulation and genomic instability contributing to aging and age-related diseases. The group applies interdisciplinary approaches to address how regulated instruction of proliferative fitness and genomic stability decelerates senescence in mouse models of Down syndrome, progeria and aging. Within i3S Cancer Program, EL is tackling the question on how aging is the major risk factor for tumorigenesis, with focus on chromosomal instability and senescence. EL is currently vice-coordinator of the Cancer Program and member of the Restrictive Scientific Council. </p> </div> </div> <div class="elementor-element elementor-element-4f23c3e elementor-widget__width-initial elementor-widget elementor-widget-text-editor" data-id="4f23c3e" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Talk Summary</p> </div> </div> <div class="elementor-element elementor-element-9e7cea0 elementor-widget__width-initial elementor-widget elementor-widget-text-editor" data-id="9e7cea0" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>One of the major goals of aging research is to develop strategies to delay and even reverse aging. Emerging findings indicate that genomic variations are a relevant and under-recognized mechanism underlying human aging and age-related diseases. Our group has been focused on genetic and pharmacological interventions protecting against genomic instability and addressing their impact in senescence accrual. Our recent findings will be presented.</p> </div> </div> <div class="elementor-element elementor-element-15345d8 elementor-widget elementor-widget-text-editor" data-id="15345d8" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><em>Chairs: Javier Garcia-Pardo (UAB) and Susanna Navarro (UAB)</em></strong></p> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-inner-section elementor-element elementor-element-765b7ff elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="765b7ff" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-f7825b2" data-id="f7825b2" data-element_type="column"> <div class="elementor-widget-wrap"> </div> </div> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-f660eae" data-id="f660eae" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> </div> </div> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-e6e9d4f" data-id="e6e9d4f" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-af04744 elementor-widget elementor-widget-button" data-id="af04744" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-xs" href="https://youtu.be/rBVIciA6q58" target="_blank" rel="noopener"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-text">Webinar</span> </span> </a> </div> </div> </div> </div> </div> </div> </section> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-0670795 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="0670795" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-bf07ea1" data-id="bf07ea1" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-a264e03 elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="a264e03" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <div class="elementor-divider"> <span class="elementor-divider-separator"> </span> </div> </div> </div> <div class="elementor-element elementor-element-eeecce0 elementor-widget elementor-widget-spacer" data-id="eeecce0" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-c055f96 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="c055f96" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f9a8f98" data-id="f9a8f98" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-d6ea190 elementor-widget elementor-widget-heading" data-id="d6ea190" data-element_type="widget" data-widget_type="heading.default"> <div class="elementor-widget-container"> <h2 class="elementor-heading-title elementor-size-default">26 April 2021 | ONLINE EVENT</h2> </div> </div> <div class="elementor-element elementor-element-7cc5169 elementor-widget elementor-widget-spacer" data-id="7cc5169" data-element_type="widget" data-widget_type="spacer.default"> <div class="elementor-widget-container"> <div class="elementor-spacer"> <div class="elementor-spacer-inner"></div> </div> </div> </div> <section class="elementor-section elementor-inner-section elementor-element elementor-element-1dca700 elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="1dca700" data-element_type="section"> <div class="elementor-container elementor-column-gap-narrow"> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-2837c7c" data-id="2837c7c" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-460faae elementor-widget elementor-widget-image" data-id="460faae" data-element_type="widget" data-widget_type="image.default"> <div class="elementor-widget-container"> <img decoding="async" src="https://phasage.eu/wp-content/uploads/elementor/thumbs/Peter-Tompa-p2o1ofjxu0sy134qwfuqcab4os7rhkl51rv4rxmfj8.png" title="Peter Tompa" alt="" loading="lazy" /> </div> </div> </div> </div> <div class="elementor-column elementor-col-66 elementor-inner-column elementor-element elementor-element-1a5328e" data-id="1a5328e" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-b6a875d elementor-widget elementor-widget-text-editor" data-id="b6a875d" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Phase Separation: an emergent function of disordered proteins</p> </div> </div> <div class="elementor-element elementor-element-7e6775a elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor" data-id="7e6775a" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><a href="https://vib.be/labs/tompa-lab" target="_blank" rel="noopener">Peter Tompa</a></p> </div> </div> <div class="elementor-element elementor-element-14abafb elementor-widget__width-initial elementor-widget-tablet__width-initial elementor-widget elementor-widget-text-editor" data-id="14abafb" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p style="font-weight: 400;">Group Leader at VIB’s Structural Biology Research Center in Belgium. Peter is also a professor of biochemistry at the VUB (Free University Brussels), and at the Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences (Budapest, Hungary). Peter Tompa is an expert in structurally disordered proteins and phase separation research in cell physiology and disease.</p> </div> </div> <div class="elementor-element elementor-element-479c305 elementor-widget__width-initial elementor-widget elementor-widget-text-editor" data-id="479c305" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Talk Summary</p> </div> </div> <div class="elementor-element elementor-element-222afee elementor-widget__width-initial elementor-widget elementor-widget-text-editor" data-id="222afee" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p>Intrinsically disordered proteins (IDPs) lack a well-defined structure, yet they fulfil important functions in the cell. It was recently recognized that they can undergo physiological condensation (liquid-liquid phase separation, LLPS) leading to the formation of cellular membraneless organelles (MLOs), such as the nucleolus and stress granules. Due to its prevalence and importance in cell physiology and pathology, the mechanism of LLPS is recently under intense scrutiny. This seminar will cover key aspects of LLPS and the formation of MLOs, and highlight basic conceptual, computational and experimental challenges of this new field.</p> </div> </div> <div class="elementor-element elementor-element-7c0d53b elementor-widget elementor-widget-text-editor" data-id="7c0d53b" data-element_type="widget" data-widget_type="text-editor.default"> <div class="elementor-widget-container"> <p><strong><em>Chairs: Isabel Cardoso (IBMC/i3S) and Ana Rita Costa (IBMC/i3S)</em></strong></p> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-inner-section elementor-element elementor-element-98b93d7 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="98b93d7" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-385e7b4" data-id="385e7b4" data-element_type="column"> <div class="elementor-widget-wrap"> </div> </div> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-71ccb26" data-id="71ccb26" data-element_type="column"> <div class="elementor-widget-wrap"> </div> </div> <div class="elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-fb6cb4a" data-id="fb6cb4a" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-eb34099 elementor-widget elementor-widget-button" data-id="eb34099" data-element_type="widget" data-widget_type="button.default"> <div class="elementor-widget-container"> <div class="elementor-button-wrapper"> <a class="elementor-button elementor-button-link elementor-size-xs" href="https://youtu.be/-oALR0SGu58" target="_blank" rel="noopener"> <span class="elementor-button-content-wrapper"> <span class="elementor-button-text">Webinar</span> </span> </a> </div> </div> </div> </div> </div> </div> </section> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-c333f15 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="c333f15" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-571440d" data-id="571440d" data-element_type="column"> <div class="elementor-widget-wrap elementor-element-populated"> <div class="elementor-element elementor-element-459465a elementor-widget-divider--view-line elementor-widget elementor-widget-divider" data-id="459465a" data-element_type="widget" data-widget_type="divider.default"> <div class="elementor-widget-container"> <div class="elementor-divider"> <span class="elementor-divider-separator"> </span> </div> </div> </div> </div> </div> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-3434f8d elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="3434f8d" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> </div> </section> <section class="elementor-section elementor-top-section elementor-element elementor-element-88e43c7 elementor-section-boxed elementor-section-height-default elementor-section-height-default" data-id="88e43c7" data-element_type="section"> <div class="elementor-container elementor-column-gap-default"> <div class="elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-dbeda80" data-id="dbeda80" data-element_type="column"> <div class="elementor-widget-wrap"> </div> </div> </div> </section> </div> </div> </article> </main> </div> </div> </div> <footer id="colophon" class="site-footer" role="contentinfo"> <div id="footer-widgets" class="footer-widgets section-padding "> <div class="container"> <div class="row"> <div id="footer-1" class="col-md-6 col-sm-12 footer-column widget-area sidebar" role="complementary"> <aside id="text-7" class="footer-widget widget widget_text"><h2 class="widget-title">CONTACT</h2> <div class="textwidget"><p>phasageproject@i3s.up.pt</p> </div> </aside><aside id="media_image-9" class="footer-widget widget widget_media_image"><h2 class="widget-title">FOLLOW US:</h2><a href="https://twitter.com/PhasAGE_project"><img width="30" height="30" src="https://phasage.eu/wp-content/uploads/2023/08/Design-sem-nome.png" class="image wp-image-9607 attachment-30x30 size-30x30" alt="" style="max-width: 100%; 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