Integrated Bioinformatics Approach Showed Linagliptin as Potential Drug for Prevention of Cardiac Arrest and Cancer

<!DOCTYPE html> <html lang="en" xml:lang="en"> <head> <meta charset="utf-8"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <title> Integrated Bioinformatics Approach Showed Linagliptin as Potential Drug for Prevention of Cardiac Arrest and Cancer | Medinformatics </title> <link rel="icon" href="https://ojs.bonviewpress.com/public/journals/12/favicon_en_US.png"> <meta name="generator" content="Open Journal Systems 3.4.0.7"> <meta name="gs_meta_revision" content="1.1"/> <meta name="citation_journal_title" content="Medinformatics"/> <meta name="citation_journal_abbrev" content="MEDIN"/> <meta name="citation_issn" content="3029-1321"/> <meta name="citation_author" content="Bhanupriya Dhabhai"/> <meta name="citation_author_institution" content="Department of Biotechnology, Mohanlal Sukhadia University, India"/> <meta name="citation_author" content="Ramgopal Dhakar"/> <meta name="citation_author_institution" content="Department of Biotechnology, Mohanlal Sukhadia University, India"/> <meta name="citation_author" content="Vipin Ranga"/> <meta name="citation_author_institution" content="Department of Agricultural Biotechnology, Assam Agricultural University, India"/> <meta name="citation_author" content="Praveen Surolia"/> <meta name="citation_author_institution" content="Department of Chemistry, Manipal University Jaipur, India"/> <meta name="citation_author" content="Athira M. Menon"/> <meta name="citation_author_institution" content="Department of Biotechnology, Mohanlal Sukhadia University, India"/> <meta name="citation_author" content="Narendra Kumar Sharma"/> <meta name="citation_author_institution" content="Department of Biosciences and Biotechnology, Banasthali Vidyapith, India"/> <meta name="citation_author" content="Tikam Chand Dakal"/> <meta name="citation_author_institution" content="Department of Biotechnology, Mohanlal Sukhadia University, India"/> <meta name="citation_author" content="Darshan Lohar"/> <meta name="citation_author_institution" content="Department of Biotechnology, Mohanlal Sukhadia University, India"/> <meta name="citation_title" content="Integrated Bioinformatics Approach Showed Linagliptin as Potential Drug for Prevention of Cardiac Arrest and Cancer"/> <meta name="citation_language" content="en"/> <meta name="citation_date" content="2024"/> <meta name="citation_volume" content="1"/> <meta name="citation_issue" content="3"/> <meta name="citation_firstpage" content="131"/> <meta name="citation_lastpage" content="141"/> <meta name="citation_doi" content="10.47852/bonviewMEDIN32021408"/> <meta name="citation_abstract_html_url" content="https://ojs.bonviewpress.com/index.php/MEDIN/article/view/1408"/> <meta name="citation_abstract" xml:lang="en" content="The availability of Linagliptin as a dipeptidyl peptidase-4 (DPP4) inhibitor for the management of type 2 diabetes in individuals has been a recent development. The primary aim of the present investigation is to gain insights into the biological, physiological, and pharmacological mechanisms of action of the substance, as well as its impact on the cellular structure of human organisms. In this study, a range of genomics approaches and in silico tools were employed, including PASS, SwissTargetPrediction, SwissADME, SEA, CLC-Pred, and DIGEP-Pred, to ascertain the physiochemical characteristics, pharmacokinetic attributes, biological targets, and biological activity of Linagliptin. Linagliptin is employed as a novel DPP4 inhibitor for the purpose of assisting those diagnosed with type 2 diabetes in managing their body’s glycemic control. Nevertheless, our study revealed that Linagliptin has affinity for other molecular targets in humans, such as CHRM1, FAP, ALDH1A1, and PDE6D, thereby modulating their gene expression patterns. Prior studies have demonstrated that the administration of the medicine exerts an influence on renal and cardiovascular problems. Based on our research findings, we have developed a solid hypothesis that Linagliptin could potentially serve as an effective pharmaceutical intervention for the treatment of blood cancer and cardiac arrest. Received: 31 July 2023 | Revised: 4 September 2023 | Accepted: 20 September 2023 Conflicts of Interest The authors declare that they have no conflicts of interest to this work. Data Availability Statement The structures used in this study are openly available at https://pubchem.ncbi.nlm.nih.gov."/> <meta name="citation_keywords" xml:lang="en" content="Linagliptin"/> <meta name="citation_keywords" xml:lang="en" content="DPP4 inhibitor"/> <meta name="citation_keywords" xml:lang="en" content="diabetes"/> <meta name="citation_keywords" xml:lang="en" content="pharmacokinetics"/> <meta name="citation_keywords" xml:lang="en" content="chemoinformatics"/> <meta name="citation_pdf_url" content="https://ojs.bonviewpress.com/index.php/MEDIN/article/download/1408/632"/> <link rel="schema.DC" href="http://purl.org/dc/elements/1.1/" /> <meta name="DC.Creator.PersonalName" content="Bhanupriya Dhabhai"/> <meta name="DC.Creator.PersonalName" content="Ramgopal Dhakar"/> <meta name="DC.Creator.PersonalName" content="Vipin Ranga"/> <meta name="DC.Creator.PersonalName" content="Praveen Surolia"/> <meta name="DC.Creator.PersonalName" content="Athira M. Menon"/> <meta name="DC.Creator.PersonalName" content="Narendra Kumar Sharma"/> <meta name="DC.Creator.PersonalName" content="Tikam Chand Dakal"/> <meta name="DC.Creator.PersonalName" content="Darshan Lohar"/> <meta name="DC.Date.created" scheme="ISO8601" content="2023-09-21"/> <meta name="DC.Date.dateSubmitted" scheme="ISO8601" content="2023-07-27"/> <meta name="DC.Date.issued" scheme="ISO8601" content="2024-08-23"/> <meta name="DC.Date.modified" scheme="ISO8601" content="2024-08-23"/> <meta name="DC.Description" xml:lang="en" content="The availability of Linagliptin as a dipeptidyl peptidase-4 (DPP4) inhibitor for the management of type 2 diabetes in individuals has been a recent development. The primary aim of the present investigation is to gain insights into the biological, physiological, and pharmacological mechanisms of action of the substance, as well as its impact on the cellular structure of human organisms. In this study, a range of genomics approaches and in silico tools were employed, including PASS, SwissTargetPrediction, SwissADME, SEA, CLC-Pred, and DIGEP-Pred, to ascertain the physiochemical characteristics, pharmacokinetic attributes, biological targets, and biological activity of Linagliptin. Linagliptin is employed as a novel DPP4 inhibitor for the purpose of assisting those diagnosed with type 2 diabetes in managing their body’s glycemic control. Nevertheless, our study revealed that Linagliptin has affinity for other molecular targets in humans, such as CHRM1, FAP, ALDH1A1, and PDE6D, thereby modulating their gene expression patterns. Prior studies have demonstrated that the administration of the medicine exerts an influence on renal and cardiovascular problems. Based on our research findings, we have developed a solid hypothesis that Linagliptin could potentially serve as an effective pharmaceutical intervention for the treatment of blood cancer and cardiac arrest. Received: 31 July 2023 | Revised: 4 September 2023 | Accepted: 20 September 2023 Conflicts of Interest The authors declare that they have no conflicts of interest to this work. Data Availability Statement The structures used in this study are openly available at https://pubchem.ncbi.nlm.nih.gov."/> <meta name="DC.Format" scheme="IMT" content="application/pdf"/> <meta name="DC.Identifier" content="1408"/> <meta name="DC.Identifier.pageNumber" content="131–141"/> <meta name="DC.Identifier.DOI" content="10.47852/bonviewMEDIN32021408"/> <meta name="DC.Identifier.URI" content="https://ojs.bonviewpress.com/index.php/MEDIN/article/view/1408"/> <meta name="DC.Language" scheme="ISO639-1" content="en"/> <meta name="DC.Rights" content="Copyright (c) 2023 Authors"/> <meta name="DC.Rights" content="https://creativecommons.org/licenses/by/4.0"/> <meta name="DC.Source" content="Medinformatics"/> <meta name="DC.Source.ISSN" content="3029-1321"/> <meta name="DC.Source.Issue" content="3"/> <meta name="DC.Source.Volume" content="1"/> <meta name="DC.Source.URI" content="https://ojs.bonviewpress.com/index.php/MEDIN"/> <meta name="DC.Subject" xml:lang="en" content="Linagliptin"/> <meta name="DC.Subject" xml:lang="en" content="DPP4 inhibitor"/> <meta name="DC.Subject" xml:lang="en" content="diabetes"/> <meta name="DC.Subject" xml:lang="en" content="pharmacokinetics"/> <meta name="DC.Subject" xml:lang="en" content="chemoinformatics"/> <meta name="DC.Title" content="Integrated Bioinformatics Approach Showed Linagliptin as Potential Drug for Prevention of Cardiac Arrest and Cancer"/> <meta name="DC.Type" content="Text.Serial.Journal"/> <meta name="DC.Type.articleType" content="Research Articles"/> <link rel="alternate" type="application/atom+xml" href="https://ojs.bonviewpress.com/index.php/MEDIN/gateway/plugin/AnnouncementFeedGatewayPlugin/atom"> <link rel="alternate" type="application/rdf+xml" href="https://ojs.bonviewpress.com/index.php/MEDIN/gateway/plugin/AnnouncementFeedGatewayPlugin/rss"> <link rel="alternate" type="application/rss+xml" href="https://ojs.bonviewpress.com/index.php/MEDIN/gateway/plugin/AnnouncementFeedGatewayPlugin/rss2"> <link 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href="https://ojs.bonviewpress.com/index.php/MEDIN/index"> Home </a> <span class="separator">/</span> </li> <li> <a href="https://ojs.bonviewpress.com/index.php/MEDIN/issue/archive"> Archives </a> <span class="separator">/</span> </li> <li> <a href="https://ojs.bonviewpress.com/index.php/MEDIN/issue/view/92"> Vol. 1 No. 3 (2024) </a> <span class="separator">/</span> </li> <li class="current" aria-current="page"> <span aria-current="page"> Research Articles </span> </li> </ol> </nav> <article class="obj_article_details"> <h1 class="page_title"> Integrated Bioinformatics Approach Showed Linagliptin as Potential Drug for Prevention of Cardiac Arrest and Cancer </h1> <div class="row"> <div class="main_entry"> <section class="item authors"> <h2 class="pkp_screen_reader">Authors</h2> <ul class="authors"> <li> <span class="name"> Bhanupriya Dhabhai </span> <span class="affiliation"> Department of Biotechnology, Mohanlal Sukhadia University, India </span> </li> <li> <span class="name"> Ramgopal Dhakar </span> <span class="affiliation"> Department of Biotechnology, Mohanlal Sukhadia University, India </span> </li> <li> <span class="name"> Vipin Ranga </span> <span class="affiliation"> Department of Agricultural Biotechnology, Assam Agricultural University, India </span> </li> <li> <span class="name"> Praveen Surolia </span> <span class="affiliation"> Department of Chemistry, Manipal University Jaipur, India </span> </li> <li> <span class="name"> Athira M. Menon </span> <span class="affiliation"> Department of Biotechnology, Mohanlal Sukhadia University, India </span> </li> <li> <span class="name"> Narendra Kumar Sharma </span> <span class="affiliation"> Department of Biosciences and Biotechnology, Banasthali Vidyapith, India </span> <span class="orcid"> <svg class="orcid_icon" viewBox="0 0 256 256" aria-hidden="true"> <style type="text/css"> .st0{fill:#A6CE39;} .st1{fill:#FFFFFF;} </style> <path class="st0" d="M256,128c0,70.7-57.3,128-128,128C57.3,256,0,198.7,0,128C0,57.3,57.3,0,128,0C198.7,0,256,57.3,256,128z"/> <g> <path class="st1" d="M86.3,186.2H70.9V79.1h15.4v48.4V186.2z"/> <path class="st1" d="M108.9,79.1h41.6c39.6,0,57,28.3,57,53.6c0,27.5-21.5,53.6-56.8,53.6h-41.8V79.1z M124.3,172.4h24.5 c34.9,0,42.9-26.5,42.9-39.7c0-21.5-13.7-39.7-43.7-39.7h-23.7V172.4z"/> <path class="st1" d="M88.7,56.8c0,5.5-4.5,10.1-10.1,10.1c-5.6,0-10.1-4.6-10.1-10.1c0-5.6,4.5-10.1,10.1-10.1 C84.2,46.7,88.7,51.3,88.7,56.8z"/> </g> </svg> <a href="https://orcid.org/0000-0002-8681-3840" target="_blank"> https://orcid.org/0000-0002-8681-3840 </a> </span> </li> <li> <span class="name"> Tikam Chand Dakal </span> <span class="affiliation"> Department of Biotechnology, Mohanlal Sukhadia University, India </span> <span class="orcid"> <svg class="orcid_icon" viewBox="0 0 256 256" aria-hidden="true"> <style type="text/css"> .st0{fill:#A6CE39;} .st1{fill:#FFFFFF;} </style> <path class="st0" d="M256,128c0,70.7-57.3,128-128,128C57.3,256,0,198.7,0,128C0,57.3,57.3,0,128,0C198.7,0,256,57.3,256,128z"/> <g> <path class="st1" d="M86.3,186.2H70.9V79.1h15.4v48.4V186.2z"/> <path class="st1" d="M108.9,79.1h41.6c39.6,0,57,28.3,57,53.6c0,27.5-21.5,53.6-56.8,53.6h-41.8V79.1z M124.3,172.4h24.5 c34.9,0,42.9-26.5,42.9-39.7c0-21.5-13.7-39.7-43.7-39.7h-23.7V172.4z"/> <path class="st1" d="M88.7,56.8c0,5.5-4.5,10.1-10.1,10.1c-5.6,0-10.1-4.6-10.1-10.1c0-5.6,4.5-10.1,10.1-10.1 C84.2,46.7,88.7,51.3,88.7,56.8z"/> </g> </svg> <a href="https://orcid.org/0000-0002-9248-7391" target="_blank"> https://orcid.org/0000-0002-9248-7391 </a> </span> </li> <li> <span class="name"> Darshan Lohar </span> <span class="affiliation"> Department of Biotechnology, Mohanlal Sukhadia University, India </span> </li> </ul> </section> <section class="item doi"> <h2 class="label"> DOI: </h2> <span class="value"> <a href="https://doi.org/10.47852/bonviewMEDIN32021408"> https://doi.org/10.47852/bonviewMEDIN32021408 </a> </span> </section> <section class="item keywords"> <h2 class="label"> Keywords: </h2> <span class="value"> Linagliptin, DPP4 inhibitor, diabetes, pharmacokinetics, chemoinformatics </span> </section> <section class="item abstract"> <h2 class="label">Abstract</h2> <p>The availability of Linagliptin as a dipeptidyl peptidase-4 (DPP4) inhibitor for the management of type 2 diabetes in individuals has been a recent development. The primary aim of the present investigation is to gain insights into the biological, physiological, and pharmacological mechanisms of action of the substance, as well as its impact on the cellular structure of human organisms. In this study, a range of genomics approaches and in silico tools were employed, including PASS, SwissTargetPrediction, SwissADME, SEA, CLC-Pred, and DIGEP-Pred, to ascertain the physiochemical characteristics, pharmacokinetic attributes, biological targets, and biological activity of Linagliptin. Linagliptin is employed as a novel DPP4 inhibitor for the purpose of assisting those diagnosed with type 2 diabetes in managing their body’s glycemic control. Nevertheless, our study revealed that Linagliptin has affinity for other molecular targets in humans, such as <em>CHRM1</em>,<em> FAP</em>, <em>ALDH1A1</em>, and<em> PDE6D</em>, thereby modulating their gene expression patterns. Prior studies have demonstrated that the administration of the medicine exerts an influence on renal and cardiovascular problems. Based on our research findings, we have developed a solid hypothesis that Linagliptin could potentially serve as an effective pharmaceutical intervention for the treatment of blood cancer and cardiac arrest.</p> <p> </p> <p><strong>Received:</strong> 31 July 2023 <strong>| Revised:</strong> 4 September 2023 <strong>| Accepted:</strong> 20 September 2023</p> <p> </p> <p><strong>Conflicts of Interest</strong></p> <p>The authors declare that they have no conflicts of interest to this work.</p> <p> </p> <p><strong>Data Availability Statement</strong></p> <p>The structures used in this study are openly available at <a href="https://pubchem.ncbi.nlm.nih.gov">https://pubchem.ncbi.nlm.nih.gov</a>.</p> </section> <br /><div class="separator"></div><div class="item abstract" id="trendmd-suggestions"></div><script defer src='//js.trendmd.com/trendmd.min.js' data-trendmdconfig='{"website_id":"89271", "element":"#trendmd-suggestions"}'></script> </div> <div class="entry_details"> <div class="item cover_image"> <div class="sub_item"> <a href="https://ojs.bonviewpress.com/index.php/MEDIN/issue/view/92"> <img src="https://ojs.bonviewpress.com/public/journals/12/cover_issue_92_en_US.png" alt=""> </a> </div> </div> <div class="item galleys"> <h2 class="pkp_screen_reader"> Downloads </h2> <ul class="value galleys_links"> <li> <a class="obj_galley_link pdf" href="https://ojs.bonviewpress.com/index.php/MEDIN/article/view/1408/632"> PDF </a> </li> </ul> </div> <div class="item published"> <section class="sub_item"> <h2 class="label"> Published </h2> <div class="value"> <span>2023-09-21</span> </div> </section> </div> <div class="item issue"> <section class="sub_item"> <h2 class="label"> Issue </h2> <div class="value"> <a class="title" href="https://ojs.bonviewpress.com/index.php/MEDIN/issue/view/92"> Vol. 1 No. 3 (2024) </a> </div> </section> <section class="sub_item"> <h2 class="label"> Section </h2> <div class="value"> Research Articles </div> </section> </div> <div class="item copyright"> <h2 class="label"> License </h2> <p>Copyright (c) 2023 Authors</p> <a rel="license" href="https://creativecommons.org/licenses/by/4.0/"><img alt="Creative Commons License" src="//i.creativecommons.org/l/by/4.0/88x31.png" /></a><p>This work is licensed under a <a rel="license" href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International License</a>.</p> </div> <div class="item citation"> <section class="sub_item citation_display"> <h2 class="label"> How to Cite </h2> <div class="value"> <div id="citationOutput" role="region" aria-live="polite"> <div class="csl-bib-body"> <div class="csl-entry">Integrated Bioinformatics Approach Showed Linagliptin as Potential Drug for Prevention of Cardiac Arrest and Cancer. 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