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neuropathy</title> <meta name="description" content="Search results for: peripheral neuropathy"> <meta name="keywords" content="peripheral neuropathy"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="peripheral neuropathy"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 454</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: peripheral neuropathy</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">454</span> An Observational Study of Vitamin B12 Levels and Peripheral Neuropathy Profile in Patients of Diabetes Mellitus on Metformin Therapy</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kamesh%20Gupta">Kamesh Gupta</a>, <a href="https://publications.waset.org/abstracts/search?q=Nitin%20Jain"> Nitin Jain</a>, <a href="https://publications.waset.org/abstracts/search?q=Anurag%20Rohatgi"> Anurag Rohatgi </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objective: To study Vitamin B12 levels and presence of peripheral neuropathy among diabetes mellitus patients on metformin therapy. Method: The observational study was conducted from November 2014 to March 2015. Patients were selected from the Lady Hardinge Medical College, Delhi, India. Exhaustive history regarding dietary habits and metformin usage was taken. Lab tests including HbA1c levels and Vit B12 assays were done, on the basis of which patients were classified into subgroups. Peripheral neuropathy was detected by both clinical scoring and electrophysiological studies. Appropriate Statistical analysis for observational studies was done to evaluate the data. Results: The average duration of metformin usage was higher in patients with definite B12 deficiency (9.4y) than patients with normal B12 levels (5.6 y). Patients in the definite B12 deficiency group had much higher incidence of neuropathy (89%) than patients with no deficiency (27%). The incidence of neuropathy was higher in cases with longer metformin usage (100% with 18-22y of use and 83% with 14-17y of use) than shorter periods (29% with 2-5y of use and 75% with 6-9y of use). Conclusion: Thus patients on long-term metformin therapy are at a high risk for Vitamin B12 deficiency. Definite and possible Vitamin B12 deficiency on metformin had an earlier onset of neuropathy than the subgroup with normal Vitamin B12 levels. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diabetic%20neuroptahy" title="diabetic neuroptahy">diabetic neuroptahy</a>, <a href="https://publications.waset.org/abstracts/search?q=cobalamine%20deficiency" title=" cobalamine deficiency"> cobalamine deficiency</a>, <a href="https://publications.waset.org/abstracts/search?q=metformin" title=" metformin"> metformin</a>, <a href="https://publications.waset.org/abstracts/search?q=nerve%20conduction%20studies" title=" nerve conduction studies"> nerve conduction studies</a> </p> <a href="https://publications.waset.org/abstracts/67975/an-observational-study-of-vitamin-b12-levels-and-peripheral-neuropathy-profile-in-patients-of-diabetes-mellitus-on-metformin-therapy" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/67975.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">365</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">453</span> Association of Ankle Brachial Index with Diabetic Score Neuropathy Examination in Type 2 Diabetes Melitus Patients</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=A.%20K.%20Putri">A. K. Putri</a>, <a href="https://publications.waset.org/abstracts/search?q=A.Fitri"> A.Fitri</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20A.%20Batubara"> C. A. Batubara</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Diabetes Mellitus (DM) is a chronic disease that could cause complications. The complication can be Peripheral Arterial Disease (PAD) or Diabetic Neuropathy (DN). Peripheral Arterial Disease is checked by Ankle Brachial Index (ABI), DN is checked by Diabetic Neuropathy Examination (DNE) score. To determine the association of ABI and DNE score in DM type 2. This study uses a cross-sectional design. The subjects were DM patients at the neurology and endocrinology polyclinic at Haji Adam Malik Hospital Medan and its network hospital and this study subjects were examined for ABI and DNE scores. The data were analysed using the Fisher Exact statistics test. Demographics characteristic showed most of subject are female (51,6%), age range ≥ 60 (45.2% ; average 57,6 ± 9,8 years ), and history of DM 5-10 years (45,2%). The most patient ABI characteristics were mild PAD (42%) and moderate PAD (29%). The most patient DNE Score characteristics were≥ 3 (51,6%). There’s a significant relationship between ABI and DNE score in DM type 2 (p =0.016). Conclusion: There is a significant association between ABI and DNE scores in DM type 2 patients <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diabetic%20neuropathy" title="diabetic neuropathy">diabetic neuropathy</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetes%20mellitus" title=" diabetes mellitus"> diabetes mellitus</a>, <a href="https://publications.waset.org/abstracts/search?q=ankle-brachial%20index" title=" ankle-brachial index"> ankle-brachial index</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetic%20neuropathy%20examination" title=" diabetic neuropathy examination"> diabetic neuropathy examination</a> </p> <a href="https://publications.waset.org/abstracts/147299/association-of-ankle-brachial-index-with-diabetic-score-neuropathy-examination-in-type-2-diabetes-melitus-patients" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/147299.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">113</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">452</span> Analysis of Gait Characteristics Using Dynamic Foot Scanner in Type 2 Diabetes Mellitus</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=C.%20G.%20Shashi%20Kumar">C. G. Shashi Kumar</a>, <a href="https://publications.waset.org/abstracts/search?q=G.%20Arun%20Maiya"> G. Arun Maiya</a>, <a href="https://publications.waset.org/abstracts/search?q=H.%20Manjunath%20Hande"> H. Manjunath Hande</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20V.%20Rajagopal"> K. V. Rajagopal</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Diabetes mellitus (DM) is a metabolic disorder with involvement of neurovascular and muscular system. Studies have documented that the gait parameter is altered in type 2 diabetes mellitus with peripheral neuropathy. However, there is a dearth of literature regarding the gait characteristics in type 2 diabetes mellitus (T2DM) without peripheral neuropathy. Therefore, the present study is focused on identifying gait changes in early type 2 diabetes mellitus without peripheral neuropathy. Objective: To analyze the gait characteristics in Type 2 diabetes mellitus without peripheral neuropathy. Methods: After obtaining ethical clearance from Institutional Ethical Committee (IEC), 36 T2DM without peripheral neuropathy and 32 matched healthy subjects were recruited. Gait characteristics (step duration, gait cycle length, gait cycle duration, stride duration, step length, double stance duration) of all the subjects were analyzed using Windtrack dynamic foot scanner. Data were analyzed using Independent‘t’ test to find the difference between the groups (step duration, gait cycle length, gait cycle duration) and Mann-Whitney test was used to analyze the step length and double stance duration to find difference between the groups. Level of significance was kept at P<0.05. Results: Result analysis showed significant decrease in step duration, gait cycle length, gait cycle duration, step length, double stance duration in T2DM subjects as compared to healthy subjects. We also observed a mean increase in stride duration in T2DM subjects compared to healthy subjects. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=type%202%20diabetes%20mellitus" title="type 2 diabetes mellitus">type 2 diabetes mellitus</a>, <a href="https://publications.waset.org/abstracts/search?q=dynamic%20foot%20scan" title=" dynamic foot scan"> dynamic foot scan</a>, <a href="https://publications.waset.org/abstracts/search?q=gait%20characteristics" title=" gait characteristics"> gait characteristics</a>, <a href="https://publications.waset.org/abstracts/search?q=medical%20and%20health%20sciences" title=" medical and health sciences"> medical and health sciences</a> </p> <a href="https://publications.waset.org/abstracts/13512/analysis-of-gait-characteristics-using-dynamic-foot-scanner-in-type-2-diabetes-mellitus" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/13512.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">440</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">451</span> The Preventive Effect of Metformin on Paclitaxel-Induced Peripheral Neuropathy</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=AliAkbar%20Hafezi">AliAkbar Hafezi</a>, <a href="https://publications.waset.org/abstracts/search?q=Jamshid%20Abedi"> Jamshid Abedi</a>, <a href="https://publications.waset.org/abstracts/search?q=Jalal%20Taherian"> Jalal Taherian</a>, <a href="https://publications.waset.org/abstracts/search?q=Behnam%20Kadkhodaei"> Behnam Kadkhodaei</a>, <a href="https://publications.waset.org/abstracts/search?q=Mahsa%20Elahi"> Mahsa Elahi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background. Peripheral neuropathy is a common side effect of the administration of neurotoxic chemotherapy agents. This adverse effect is a major dose-limiting factor of many commonly used chemotherapy drugs. Currently, there are no Food and Drug Administration (FDA) approved medications for the prevention or treatment of chemotherapy-induced peripheral neuropathy. Therefore, this study was performed to investigate the efficacy and safety of metformin on paclitaxel-induced peripheral neuropathy (PIPN). Methods. In this randomized clinical trial, cancer patients who were candidates for chemotherapy with paclitaxel referred to the radiation oncology departments in Iran from 2022 to 2023 were studied. Patients were randomly divided into two groups; 1- Case group (n = 30) received metformin 500 mg orally twice a day after meals during chemotherapy with paclitaxel, and 2- Control group (30 people) received chemotherapy without metformin or any additional medication. Patients were visited in terms of numbness or other neurological symptoms two weeks before chemotherapy, 1-2 days before and weekly during chemotherapy, and at the end of the study. They were assessed by nerve conduction study (NCS) before intervention and one week after the end of chemotherapy. The primary outcome was the efficacy in reducing PIPN and the secondary outcome was adverse effects. Eventually, the outcomes were compared between the two groups of patients. Results. A total of 60 female cancer patients receiving chemotherapy with paclitaxel were evaluated in two groups. The groups were matched in terms of age, body mass index, fasting blood sugar, smoking, pathologic stage, and creatinine levels. The results showed that 18 patients (60.0 %) in the case group and 23 patients (76.6 %) in the control group had PIPN clinically (P = 0.267), and NCS showed 11 patients (36.6 %) in the case group and 15 patients (50.0 %) in the control group suffered from PIPN which no significant difference was observed between the two groups (P = 0.435). Diarrhea (n = 3; 10.0 %) and nausea (n = 3; 10.0 %) were the most common side effects of metformin in the case group and no serious side effects (lactic acidosis and anemia) were found in these patients. Conclusion. This study indicated that metformin did not significantly prevent PIPN in cancer patients receiving chemotherapy, although the frequency of peripheral neuropathy in the case group was lower than in the control group. The use of metformin in the patients had acceptable safety and no serious side effects were reported. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=peripheral%20neuropathy" title="peripheral neuropathy">peripheral neuropathy</a>, <a href="https://publications.waset.org/abstracts/search?q=chemotherapy" title=" chemotherapy"> chemotherapy</a>, <a href="https://publications.waset.org/abstracts/search?q=paclitaxel" title=" paclitaxel"> paclitaxel</a>, <a href="https://publications.waset.org/abstracts/search?q=metformin" title=" metformin"> metformin</a> </p> <a href="https://publications.waset.org/abstracts/185765/the-preventive-effect-of-metformin-on-paclitaxel-induced-peripheral-neuropathy" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/185765.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">43</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">450</span> Clinical Parameters Response to Low Level Laser Versus Monochromatic Near Infrared Photo Energy in Diabetic Patient with Peripheral Neuropathy</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Abeer%20Ahmed%20Abdehameed">Abeer Ahmed Abdehameed </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Diabetic sensorimotor polyneuropathy (DSP) is one of the most common micro vascular complications of type 2 diabetes. Loss of sensation is thought to contribute to lake of static and dynamic stability and increased risk of falling. Purpose: The purpose of this study was to compare the effects of low level laser (LLL) and monochromatic near infrared photo energy (MIRE) on pain , cutaneous sensation, static stability and index of lower limb blood flow in diabetic with peripheral neuropathy. Methods: Forty subjects with diabetic peripheral neuropathy were recruited for study. They were divided into two groups: The ( MIRE) group that included (20) patients and (LLL) group included (20) patients. All patients in the study had been subjected to various physical assessment procedures including pain, cutaneous sensation, Doppler flow meter and static stability assessments. The baseline measurements were followed by treatment sessions that conducted twice a week for 6 successive weeks. Results: The statistical analysis of the data had revealed significant improvement of the pain in both groups, with significant improvement in cutaneous sensation and static balance in (MIRE) group compared to (LLL) group; on the other hand results showed no significant differences on lower limb blood flow in both groups. Conclusion: Low level laser and monochromatic near infrared therapy can improve painful symptoms in patients with diabetic neuropathy. On the other hand (MIRE) is useful in improving cutaneous sensation and static stability in patients with diabetic neuropathy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diabetic%20neuropathy" title="diabetic neuropathy">diabetic neuropathy</a>, <a href="https://publications.waset.org/abstracts/search?q=doppler%20flow%20meter" title=" doppler flow meter"> doppler flow meter</a>, <a href="https://publications.waset.org/abstracts/search?q=low%20level%20laser" title=" low level laser"> low level laser</a>, <a href="https://publications.waset.org/abstracts/search?q=monochromatic%20near%20infrared%20photo%20energy" title=" monochromatic near infrared photo energy"> monochromatic near infrared photo energy</a> </p> <a href="https://publications.waset.org/abstracts/31260/clinical-parameters-response-to-low-level-laser-versus-monochromatic-near-infrared-photo-energy-in-diabetic-patient-with-peripheral-neuropathy" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/31260.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">314</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">449</span> Effect of Whole Body Vibration on Posture Stability and Planter Pressure in Patients with Diabetic Neuropathy</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Azza%20M.%20Atya">Azza M. Atya</a>, <a href="https://publications.waset.org/abstracts/search?q=Mahmoud%20M.%20Nasser"> Mahmoud M. Nasser </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background/ /Significance: Peripheral neuropathy is one of the long term serious complications of diabetes, which may attribute to postural instability and alteration of planter pressure. Whole body vibration (WBV) is a somatosensory stimulation type of exercise that has been emerged in sport training and rehabilitation of neuromuscular disorders. Purpose: The aim of this study was to investigate the effect of whole Body Vibration on antroposterior (AP), mediolateral (ML) posture stability and planter foot pressure in patients with diabetic neuropathy. Subjects: forty diabetic patients with moderate peripheral neuropathy aged from 35 to 50 years, were randomly assigned to WBV group (n=20) and control group (n=20). Methods and Materials: the WBV intervention consisted of three session weekly for 8 weeks (frequency 20 Hz, peak-to peak displacement 4mm, acceleration 3.5 g). Biodex balance system was used for postural stability assessment and the foot scan plate was used to measure the mean peak pressure under the first and lesser metatarsals. The main Outcome measures were antroposterior stability index (APSI), mediolateral stability index (MLSI), overall stability index (OSI),and mean peak foot pressure. Analyses: Statistical analysis was performed using the SPSS software package (SPSS for Windows Release 18.0). T-test was used to compare between the pre- and post-treatment values between and within groups. Results: For the 40 study participants (18male and 22 females) there were no between-group differences at baseline. At the end of 8 weeks, Subjects in WBV group experienced significant increase in postural stability with a reduction of mean peak of planter foot pressure (P<0.05) compared with the control group. Conclusion: The result suggests that WBV is an effective therapeutic modality for increasing postural stability and reducing planter pressure in patients with diabetic neuropathy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=whole%20body%20vibration" title="whole body vibration">whole body vibration</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetic%20neuropathy" title=" diabetic neuropathy"> diabetic neuropathy</a>, <a href="https://publications.waset.org/abstracts/search?q=posture%20stability" title=" posture stability"> posture stability</a>, <a href="https://publications.waset.org/abstracts/search?q=foot%20pressure" title=" foot pressure"> foot pressure</a> </p> <a href="https://publications.waset.org/abstracts/17399/effect-of-whole-body-vibration-on-posture-stability-and-planter-pressure-in-patients-with-diabetic-neuropathy" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/17399.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">383</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">448</span> Early Detection of Neuropathy in Leprosy-Comparing Clinical Tests with Nerve Conduction Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Suchana%20Marahatta">Suchana Marahatta</a>, <a href="https://publications.waset.org/abstracts/search?q=Sabina%20Bhattarai"> Sabina Bhattarai</a>, <a href="https://publications.waset.org/abstracts/search?q=Bishnu%20Hari%20Paudel"> Bishnu Hari Paudel</a>, <a href="https://publications.waset.org/abstracts/search?q=Dilip%20Thakur"> Dilip Thakur</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Every year thousands of patients develop nerve damage and disabilities as a result of leprosy which can be prevented by early detection and treatment. So, early detection and treatment of nerve function impairment is of paramount importance in leprosy. Objectives: To assess the electrophysiological pattern of the peripheral nerves in leprosy patients and to compare it with clinical assessment tools. Materials and Methods: In this comparative cross-sectional study, 74 newly diagnosed leprosy patients without reaction were enrolled. They underwent thorough evaluation for peripheral nerve function impairment using clinical tests [i.e. nerve palpation (NP), monofilament (MF) testing, voluntary muscle testing (VMT)] and nerve conduction study (NCS). Clinical findings were compared with that of NCS using SPSS version 11.5. Results: NCS was impaired in 43.24% of leprosy patient at the baseline. Among them, sensory NCS was impaired in more patients (32.4%) in comparison to motor NCS (20.3%). NP, MF, and VMT were impaired in 58.1%, 25.7%, and 9.4% of the patients, respectively. Maximum concordance of monofilament testing and sensory NCS was found for sural nerve (14.7%). Likewise, the concordance of motor NP and motor NCS was the maximum for ulnar nerve (14.9%). When individual parameters of the NCS were considered, amplitude was found to be the most frequently affected parameter for both sensory and motor NCS. It was impaired in 100% of cases with abnormal NCS findings. Conclusion: Since there was no acceptable concordance between NCS findings and clinical findings, we should consider NCS whenever feasible for early detection of neuropathy in leprosy. The amplitude of both sensory nerve action potential (SNAP) and compound nerve action potential (CAMP) could be important determinants of the abnormal NCS if supported by further studies. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=leprosy" title="leprosy">leprosy</a>, <a href="https://publications.waset.org/abstracts/search?q=nerve%20function%20impairment" title=" nerve function impairment"> nerve function impairment</a>, <a href="https://publications.waset.org/abstracts/search?q=neuropathy" title=" neuropathy"> neuropathy</a>, <a href="https://publications.waset.org/abstracts/search?q=nerve%20conduction%20study" title=" nerve conduction study"> nerve conduction study</a> </p> <a href="https://publications.waset.org/abstracts/31963/early-detection-of-neuropathy-in-leprosy-comparing-clinical-tests-with-nerve-conduction-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/31963.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">319</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">447</span> Significance of Apolipoprotein E (APOE) and Fat Mass and Obesity-Associated FTO Gene Polymorphisms in Cardiac Autonomic Neuropathy Among Individuals of Kazakh Nationality</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=N.%20Bekenova">N. Bekenova</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Aitkaliyev"> A. Aitkaliyev</a>, <a href="https://publications.waset.org/abstracts/search?q=B.%20Kassiyeva"> B. Kassiyeva</a>, <a href="https://publications.waset.org/abstracts/search?q=T.%20Vochshenkova"> T. Vochshenkova</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Cardiac autonomic neuropathy is not always detected in diabetes, and its phenotypic manifestations may not be evident. Therefore, the study of genetic markers predisposing to the disease is gaining increasing relevance. Research Objective: The goal is to investigate the association of polymorphisms in the APOE and FTO genes with cardiac autonomic neuropathy among individuals of Kazakh nationality. Materials and Methods: A case-control study included 147 patients with cardiac autonomic neuropathy (cases) and 153 patients without cardiac autonomic neuropathy (controls). 300 individuals of Kazakh nationality were recruited from a hospital affiliated with the RSE ‘Medical Centre Hospital of the President's Affairs Administration of the Republic of Kazakhstan.’ Patients were genotyped for 5 FTO gene polymorphisms (rs17817449, rs1121980, rs11075995, rs9939609, rs12149832) and 2 APOE gene polymorphisms (rs429358, rs7412) using real-time PCR. Statistical analysis involved Chi-square methods and calculation of odds ratios (OR) with 95% confidence intervals (CI) and was performed using the Gen Expert genetic calculator. Results. Our research revealed an association between cardiac autonomic neuropathy and rs12149832 (FTO) and rs429358 (APOE). The AA genotype of the rs12149832 polymorphism was found to double the risk of neuropathy development, while the GA genotype decreased the risk of autonomic neuropathy (2.21 (1.38-3.52) and 0.61 (0.38-0.96), respectively, p=0.003). Additionally, we identified that the TC genotype of rs429358 predisposes individuals to the development of cardiac autonomic neuropathy, while the CC genotype decreases the risk (2.23 (1.18-4.22) and 0.26 (0.03-2.31), respectively). Conclusion. Thus, polymorphisms in the APOE and FTO genes (rs429358 and rs12149832) are associated with a predisposition to cardiac autonomic neuropathy and may play a significant role in the pathogenesis of the disease. Further research with a larger sample size and an assessment of their impact on the phenotype is necessary. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=polymorphisms" title="polymorphisms">polymorphisms</a>, <a href="https://publications.waset.org/abstracts/search?q=APOE%20gene" title=" APOE gene"> APOE gene</a>, <a href="https://publications.waset.org/abstracts/search?q=FTO%20gene" title=" FTO gene"> FTO gene</a>, <a href="https://publications.waset.org/abstracts/search?q=automatic%20neuropathy" title=" automatic neuropathy"> automatic neuropathy</a>, <a href="https://publications.waset.org/abstracts/search?q=Kazakh%20population." title=" Kazakh population."> Kazakh population.</a> </p> <a href="https://publications.waset.org/abstracts/190209/significance-of-apolipoprotein-e-apoe-and-fat-mass-and-obesity-associated-fto-gene-polymorphisms-in-cardiac-autonomic-neuropathy-among-individuals-of-kazakh-nationality" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/190209.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">23</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">446</span> Peripheral Nerves Cross-Sectional Area for the Diagnosis of Diabetic Polyneuropathy: A Meta-Analysis of Ultrasonographic Measurements</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Saeed%20Pourhassan">Saeed Pourhassan</a>, <a href="https://publications.waset.org/abstracts/search?q=Nastaran%20Maghbouli"> Nastaran Maghbouli</a> </p> <p class="card-text"><strong>Abstract:</strong></p> 1) Background It has been hypothesized that, in individuals with diabetes mellitus, the peripheral nerve is swollen due to sorbitol over-accumulation. Additionally growing evidence supported electro diagnostic study of diabetes induced neuropathy as a method having some challenges. 2) Objective To examine the performance of sonographic cross-sectional area (CSA) measurements in the diagnosis of diabetic polyneuropathy (DPN). 3) Data Sources Electronic databases, comprising PubMed and EMBASE and Google scholar, were searched for the appropriate studies before Jan 1, 2020. 4) Study Selection Eleven trials comparing different peripheral nerve CSA measurements between participants with and without DPN were included. 5) Data Extraction Study design, participants' demographic characteristics, diagnostic reference of DPN, and evaluated peripheral nerves and methods of CSA measurement. 6) Data Synthesis Among different peripheral nerves, Tibial nerve diagnostic odds ratios pooled from five studies (713 participants) were 4.46 (95% CI, 0.35–8.57) and the largest one with P<0.0001, I²:64%. Median nerve CSA at wrist and mid-arm took second and third place with ORs= 2.82 (1.50-4.15), 2.02(0.26-3.77) respectively. The sensitivities and specificities pooled from two studies for Sural nerve were 0.78 (95% CI, 0.68–0.89), and 0.68 (95% CI, 0.53–0.74). Included studies for other nerves were limited to one study. The largest sensitivity was for Sural nerve and the largest specificity was for Tibial nerve. 7) Conclusions The peripheral nerves CSA measured by ultrasound imaging is useful for the diagnosis of DPN and is most significantly different between patients and participants without DPN at the Tibial nerve. Because the Tibial nerve CSA in healthy participants, at various locations, rarely exceeds 24 mm2, this value can be considered as a cutoff point for diagnosing DPN. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diabetes" title="diabetes">diabetes</a>, <a href="https://publications.waset.org/abstracts/search?q=diagnosis" title=" diagnosis"> diagnosis</a>, <a href="https://publications.waset.org/abstracts/search?q=polyneuropathy" title=" polyneuropathy"> polyneuropathy</a>, <a href="https://publications.waset.org/abstracts/search?q=ultrasound" title=" ultrasound"> ultrasound</a> </p> <a href="https://publications.waset.org/abstracts/124321/peripheral-nerves-cross-sectional-area-for-the-diagnosis-of-diabetic-polyneuropathy-a-meta-analysis-of-ultrasonographic-measurements" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/124321.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">135</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">445</span> Amniotic Fluid Mesenchymal Stem Cells Selected for Neural Specificity Ameliorates Chemotherapy Induced Hearing Loss and Pain Perception</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jan%20F.%20Talts">Jan F. Talts</a>, <a href="https://publications.waset.org/abstracts/search?q=Amit%20Saxena"> Amit Saxena</a>, <a href="https://publications.waset.org/abstracts/search?q=K%C3%A5re%20Engkilde"> Kåre Engkilde</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most frequent side effects caused by anti-neoplastic agents, with a prevalence from 19 % to 85 %. Clinically, CIPN is a mostly sensory neuropathy leading to pain and to motor and autonomic changes. Due to its high prevalence among cancer patients, CIPN constitutes a major problem for both cancer patients and survivors, especially because currently, there is no single effective method of preventing CIPN. Hearing loss is the most common form of sensory impairment in humans and can be caused by ototoxic chemical compounds such as chemotherapy (platinum-based antineoplastic agents).In rodents, single or repeated cisplatin injections induce peripheral neuropathy and hearing impairment mimicking human disorder, allowing studying the efficacy of new pharmacological candidates in chemotherapy-induced hearing loss and peripheral neuropathy. RNA sequencing data from full term amniotic fluid (TAF) mesenchymal stemcell (MSC) clones was used to identify neural-specific markers present on TAF-MSC. Several prospective neural markers were tested by flow cytometry on cultured TAF-MSC. One of these markers was used for cell-sorting using Tyto MACSQuant cell sorter, and the neural marker positive cell population was expanded for several passages to the final therapeutic product stage. Peripheral neuropathy and hearing loss was induced in mice by administration of cisplatin in three week-long cycles. The efficacy of neural-specific TAF-MSC in treating hearing loss and pain perception was evaluated by administration of three injections of 3 million cells/kg by intravenous route or three injections of 3 million cells/kg by intra-arterial route after each cisplatin cycle treatment. Auditory brainstem responses (ABR) are electric potentials recorded from scalp electrodes, and the first ABR wave represents the summed activity of the auditory nerve fibers contacting the inner hair cells. For ABR studies, mice were anesthetized, then earphones were placed in the left ear of each mouse, an active electrode was placed in the vertex of the skull, a reference electrode under the skin of the mastoid bone, and a ground electrode in the neck skin. The stimuli consisted of tone pips of five frequencies (2, 4, 6, 12, 16, and 24 kHz) at various sound levels (from 0 to 90 dB) ranging to cover the mouse auditory frequency range. The von Frey test was used to assess the onset and maintenance of mechanical allodynia over time. Mice were placed in clear plexiglass cages on an elevated mesh floor and tested after 30 min of habituation. Mechanical paw withdrawal threshold was examined using an electronic von Frey anesthesiometer. Cisplatin groups treated with three injections of 3 million cells/kg by intravenous route and three injections of 3 million cells/kg by intra-arterial route after each cisplatin cycle treatment presented, a significant increase of hearing acuity characterized by a decrease of ABR threshold and a decrease of neuropathic pain characterized by an increase of von Frey paw withdrawal threshold compared to controls only receiving cisplatin. This study shows that treatment with MSCselected for neural specificity presents significant positive efficacy on the chemotherapy-induced neuropathic pain and the chemotherapy-induced hearing loss. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=mesenchymal%20stem%20cell" title="mesenchymal stem cell">mesenchymal stem cell</a>, <a href="https://publications.waset.org/abstracts/search?q=peripheral%20neuropathy" title=" peripheral neuropathy"> peripheral neuropathy</a>, <a href="https://publications.waset.org/abstracts/search?q=amniotic%20fluid" title=" amniotic fluid"> amniotic fluid</a>, <a href="https://publications.waset.org/abstracts/search?q=regenerative%20medicine" title=" regenerative medicine"> regenerative medicine</a> </p> <a href="https://publications.waset.org/abstracts/152319/amniotic-fluid-mesenchymal-stem-cells-selected-for-neural-specificity-ameliorates-chemotherapy-induced-hearing-loss-and-pain-perception" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/152319.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">166</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">444</span> Modeling Taxane-Induced Peripheral Neuropathy Ex Vivo Using Patient-Derived Neurons</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=G.%20Cunningham">G. Cunningham</a>, <a href="https://publications.waset.org/abstracts/search?q=E.%20Cantor"> E. Cantor</a>, <a href="https://publications.waset.org/abstracts/search?q=X.%20Wu"> X. Wu</a>, <a href="https://publications.waset.org/abstracts/search?q=F.%20Shen"> F. Shen</a>, <a href="https://publications.waset.org/abstracts/search?q=G.%20Jiang"> G. Jiang</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Philips"> S. Philips</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20Bales"> C. Bales</a>, <a href="https://publications.waset.org/abstracts/search?q=Y.%20Xiao"> Y. Xiao</a>, <a href="https://publications.waset.org/abstracts/search?q=T.%20R.%20Cummins"> T. R. Cummins</a>, <a href="https://publications.waset.org/abstracts/search?q=J.%20C.%20Fehrenbacher"> J. C. Fehrenbacher</a>, <a href="https://publications.waset.org/abstracts/search?q=B.%20P.%20Schneider"> B. P. Schneider</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Taxane-induced peripheral neuropathy (TIPN) is the most devastating survivorship issue for patients receiving therapy. Dose reductions due to TIPN in the curative setting lead to inferior outcomes for African American patients, as prior research has shown that this group is more susceptible to developing severe neuropathy. The mechanistic underpinnings of TIPN, however, have not been entirely elucidated. While it would be appealing to use primary tissue to study the development of TIPN, procuring nerves from patients is not realistically feasible, as nerve biopsies are painful and may result in permanent damage. Therefore, our laboratory has investigated paclitaxel-induced neuronal morphological and molecular changes using an ex vivo model of human-induced pluripotent stem cell (iPSC)-derived neurons. Methods: iPSCs are undifferentiated and endlessly dividing cells that can be generated from a patient’s somatic cells, such as peripheral blood mononuclear cells (PBMCs). We successfully reprogrammed PBMCs into iPSCs using the Erythroid Progenitor Reprograming Kit (STEMCell Technologiesᵀᴹ); pluripotency was verified by flow cytometry analysis. iPSCs were then induced into neurons using a differentiation protocol that bypasses the neural progenitor stage and uses selected small-molecule modulators of key signaling pathways (SMAD, Notch, FGFR1 inhibition, and Wnt activation). Results: Flow cytometry analysis revealed expression of core pluripotency transcription factors Nanog, Oct3/4 and Sox2 in iPSCs overlaps with commercially purchased pluripotent cell line UCSD064i-20-2. Trilineage differentiation of iPSCs was confirmed with immunofluorescent imaging with germ-layer-specific markers; Sox17 and ExoA2 for ectoderm, Nestin, and Pax6 for mesoderm, and Ncam and Brachyury for endoderm. Sensory neuron markers, β-III tubulin, and Peripherin were applied to stain the cells for the maturity of iPSC-derived neurons. Patch-clamp electrophysiology and calcitonin gene-related peptide (CGRP) release data supported the functionality of the induced neurons and provided insight into the timing for which downstream assays could be performed (week 4 post-induction). We have also performed a cell viability assay and fluorescence-activated cell sorting (FACS) using four cell-surface markers (CD184, CD44, CD15, and CD24) to select a neuronal population. At least 70% of the cells were viable in the isolated neuron population. Conclusion: We have found that these iPSC-derived neurons recapitulate mature neuronal phenotypes and demonstrate functionality. Thus, this represents a patient-derived ex vivo neuronal model to investigate the molecular mechanisms of clinical TIPN. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=chemotherapy" title="chemotherapy">chemotherapy</a>, <a href="https://publications.waset.org/abstracts/search?q=iPSC-derived%20neurons" title=" iPSC-derived neurons"> iPSC-derived neurons</a>, <a href="https://publications.waset.org/abstracts/search?q=peripheral%20neuropathy" title=" peripheral neuropathy"> peripheral neuropathy</a>, <a href="https://publications.waset.org/abstracts/search?q=taxane" title=" taxane"> taxane</a>, <a href="https://publications.waset.org/abstracts/search?q=paclitaxel" title=" paclitaxel"> paclitaxel</a> </p> <a href="https://publications.waset.org/abstracts/117612/modeling-taxane-induced-peripheral-neuropathy-ex-vivo-using-patient-derived-neurons" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/117612.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">122</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">443</span> Cucurbita pepo L. Attenuates Diabetic Neuropathy by Targeting Oxidative Stress in STZ-Nicotinamide Induced Diabetic Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Navpreet%20Kaur">Navpreet Kaur</a>, <a href="https://publications.waset.org/abstracts/search?q=Randhir%20Singh"> Randhir Singh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Diabetic neuropathy is one of the most common microvascular complications of diabetes mellitus which affects more than 50% of diabetic patients. The present study targeted oxidative stress mediated nerve damage in diabetic rats using a hydro-alcohol extract of Cucurbita pepo L. (Family: Cucurbitaceae) and its potential in treatment of diabetic neuropathy. Diabetes neuropathy was induced in Wistar rats by injection of streptozotocin (65 mg/kg, i.p.) 15 min after Nicotinamide (230 mg/kg, i.p.) administration. Hydro-alcohol extract of C. pepo seeds was assessed by oral administration at 100, 200 and 400 mg/kg in STZ-nicotinamide induced diabetic rats. Thermal hyperalgesia (Eddy's hot plate and tail immersion), mechanical hyperalgesia (Randall-Selitto) and tactile allodynia (Von Frey hair tests) were evaluated in all groups of streptozotocin diabetic rats to assess the extent of neuropathy. Tissue (sciatic nerve) antioxidant enzymes (SOD, CAT, GSH and LPO) levels were measured along with the formation of AGEs in serum to assess the effect of hydro-alcohol extract of C. pepo in ameliorating oxidative stress. Diabetic rats exhibited significantly decreased tail-flick latency in the tail-immersion test and decreased paw withdrawal threshold in both Randall-Selitto and von-Frey hair test. A decrease in the nociceptive threshold was accompanied by significantly increased oxidative stress in sciatic nerve of diabetic rats. Treatment with the C. pepo hydro-alcohol extract significantly attenuated all the behavioral and biochemical alterations in a dose-dependent manner. C. pepo attenuated the diabetic condition and also reversed neuropathic pain through modulation of oxidative stress and thus it may find application as a possible therapeutic agent against diabetic neuropathy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=advanced%20glycation%20end%20products" title="advanced glycation end products">advanced glycation end products</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidant%20enzymes" title=" antioxidant enzymes"> antioxidant enzymes</a>, <a href="https://publications.waset.org/abstracts/search?q=cucurbita%20pepo" title=" cucurbita pepo"> cucurbita pepo</a>, <a href="https://publications.waset.org/abstracts/search?q=hyperglycemia" title=" hyperglycemia"> hyperglycemia</a> </p> <a href="https://publications.waset.org/abstracts/42884/cucurbita-pepo-l-attenuates-diabetic-neuropathy-by-targeting-oxidative-stress-in-stz-nicotinamide-induced-diabetic-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/42884.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">297</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">442</span> Community Engagement Strategies to Assist with the Development of an RCT Among People Living with HIV</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Joyce%20K.%20Anastasi">Joyce K. Anastasi</a>, <a href="https://publications.waset.org/abstracts/search?q=Bernadette%20Capili"> Bernadette Capili</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Community Engagement Strategies to Assist with the Development of an RCT Among People Living with HIV Our research team focuses on developing and testing protocols to manage chronic symptoms. For many years, our team designed and implemented symptom management studies for people living with HIV (PLWH). We identify symptoms that are not curative and are not adequately controlled by conventional therapies. As an exemplar, we describe how we successfully engaged PLWH in developing and refining our research feasibility protocol for distal sensory peripheral neuropathy (DSP) associated with HIV. With input from PLWH with DSP, our research received National Institutes of Health (NIH) research funding support. Significance: DSP is one of the most common neurologic complications in HIV. It is estimated that DSP affects 21% to 50% of PLWH. The pathogenesis of DSP in HIV is complex and unclear. Proposed mechanisms include cytokine dysregulation, viral protein-produced neurotoxicity, and mitochondrial dysfunction associated with antiretroviral medications. There are no FDA-approved treatments for DSP in HIV. Purpose: Aims: 1) to explore the impact of DSP on the lives of PLWH, 2) to identify patients’ perspectives on successful treatments for DSP, 3) to identify interventions considered feasible and sensitive to the needs of PLWH with DSP, and 4) to obtain participant input for protocol/study design. Description of Process: We conducted a needs assessment with PLWH with DSP. From our needs assessment, we learned from the patients’ perspective detailed descriptions of their symptoms; physical functioning with DSP; self-care remedies tried, and desired interventions. We also asked about protocol scheduling, instrument clarity, study compensation, study-related burdens, and willingness to participate in a randomized controlled trial (RCT) with a placebo and a waitlist group. Implications: We incorporated many of the suggestions learned from the need assessment. We developed and completed a feasibility study that provided us with invaluable information that informed subsequent NIH-funded studies. In addition to our extensive clinical and research experience working with PLWH, learning from the patient perspective helped in developing our protocol and promoting a successful plan for recruitment and retention of study participants. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=clinical%20trial%20development" title="clinical trial development">clinical trial development</a>, <a href="https://publications.waset.org/abstracts/search?q=peripheral%20neuropathy" title=" peripheral neuropathy"> peripheral neuropathy</a>, <a href="https://publications.waset.org/abstracts/search?q=traditional%20medicine" title=" traditional medicine"> traditional medicine</a>, <a href="https://publications.waset.org/abstracts/search?q=HIV" title=" HIV"> HIV</a>, <a href="https://publications.waset.org/abstracts/search?q=AIDS" title=" AIDS"> AIDS</a> </p> <a href="https://publications.waset.org/abstracts/153681/community-engagement-strategies-to-assist-with-the-development-of-an-rct-among-people-living-with-hiv" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/153681.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">84</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">441</span> Evaluating the Effectiveness of Plantar Sensory Insoles and Remote Patient Monitoring for Early Intervention in Diabetic Foot Ulcer Prevention in Patients with Peripheral Neuropathy</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Brock%20Liden">Brock Liden</a>, <a href="https://publications.waset.org/abstracts/search?q=Eric%20Janowitz"> Eric Janowitz</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Diabetic peripheral neuropathy (DPN) affects 70% of individuals with diabetes1. DPN causes a loss of protective sensation, which can lead to tissue damage and diabetic foot ulcer (DFU) formation2. These ulcers can result in infections and lower-extremity amputations of toes, the entire foot, and the lower leg. Even after a DFU is healed, recurrence is common, with 49% of DFU patients developing another ulcer within a year and 68% within 5 years3. This case series examines the use of sensory insoles and newly available plantar data (pressure, temperature, step count, adherence) and remote patient monitoring in patients at risk of DFU. Methods: Participants were provided with custom-made sensory insoles to monitor plantar pressure, temperature, step count, and daily use and were provided with real-time cues for pressure offloading as they went about their daily activities. The sensory insoles were used to track subject compliance, ulceration, and response to feedback from real-time alerts. Patients were remotely monitored by a qualified healthcare professional and were contacted when areas of concern were seen and provided coaching on reducing risk factors and overall support to improve foot health. Results: Of the 40 participants provided with the sensory insole system, 4 presented with a DFU. Based on flags generated from the available plantar data, patients were contacted by the remote monitor to address potential concerns. A standard clinical escalation protocol detailed when and how concerns should be escalated to the provider by the remote monitor. Upon escalation to the provider, patients were brought into the clinic as needed, allowing for any issues to be addressed before more serious complications might arise. Conclusion: This case series explores the use of innovative sensory technology to collect plantar data (pressure, temperature, step count, and adherence) for DFU detection and early intervention. The results from this case series suggest the importance of sensory technology and remote patient monitoring in providing proactive, preventative care for patients at risk of DFU. This robust plantar data, with the addition of remote patient monitoring, allow for patients to be seen in the clinic when concerns arise, giving providers the opportunity to intervene early and prevent more serious complications, such as wounds, from occurring. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diabetic%20foot%20ulcer" title="diabetic foot ulcer">diabetic foot ulcer</a>, <a href="https://publications.waset.org/abstracts/search?q=DFU%20prevention" title=" DFU prevention"> DFU prevention</a>, <a href="https://publications.waset.org/abstracts/search?q=digital%20therapeutics" title=" digital therapeutics"> digital therapeutics</a>, <a href="https://publications.waset.org/abstracts/search?q=remote%20patient%20monitoring" title=" remote patient monitoring"> remote patient monitoring</a> </p> <a href="https://publications.waset.org/abstracts/165779/evaluating-the-effectiveness-of-plantar-sensory-insoles-and-remote-patient-monitoring-for-early-intervention-in-diabetic-foot-ulcer-prevention-in-patients-with-peripheral-neuropathy" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/165779.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">77</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">440</span> Drastic Improvement in Vision Following Surgical Excision of Juvenile Nasopharyngeal Angiofibroma with Compressive Optic Neuropathy</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sweta%20Das">Sweta Das</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This case report is a 15-year-old male who presented with painless unilateral vision loss from left optic nerve compression due to juvenile nasopharyngeal angiofibroma. JNA is a rare, benign neoplasm that causes intracranial and intraorbital bone destruction and extends aggressively into surrounding soft tissues. It accounts for <1% of all head and neck tumors, is predominantly found in pediatric males and tends to affect indigenous population disproportionately. The most common presenting symptom for JNA is epistaxis and nasal obstruction. However, it can invade orbit, chiasm and pituitary gland, causing loss of vision and field. Visual acuity and function near normalized following surgical excision. Optometry plays an important role in the diagnosis and co-management of JNA with optic nerve compression by closely monitoring afferent optic nerve function and structure, and extraocular motility. Visual function and acuity in patients with short-term compressive neuropathy may drastically improve following surgical resection as this case demonstrates. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=orbital%20mass" title="orbital mass">orbital mass</a>, <a href="https://publications.waset.org/abstracts/search?q=painless%20monocular%20vision%20loss" title=" painless monocular vision loss"> painless monocular vision loss</a>, <a href="https://publications.waset.org/abstracts/search?q=compressive%20optic%20neuropathy" title=" compressive optic neuropathy"> compressive optic neuropathy</a>, <a href="https://publications.waset.org/abstracts/search?q=pediatric%20tumor" title=" pediatric tumor"> pediatric tumor</a> </p> <a href="https://publications.waset.org/abstracts/177871/drastic-improvement-in-vision-following-surgical-excision-of-juvenile-nasopharyngeal-angiofibroma-with-compressive-optic-neuropathy" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/177871.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">59</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">439</span> Bilateral Relations in Matter of Defense between Argentina-United States and Argentina-China along the Period 2005-2015: Advice to Develop a Rational Defense Foreign Policy for Peripheral Countries</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Alvarez%20Maga%C3%B1ini">Alvarez Magañini</a>, <a href="https://publications.waset.org/abstracts/search?q=Mar%C3%ADa%20Victoria-Rubbi"> María Victoria-Rubbi</a>, <a href="https://publications.waset.org/abstracts/search?q=Lautaro%20Nahuel"> Lautaro Nahuel</a> </p> <p class="card-text"><strong>Abstract:</strong></p> At present, we are facing an unstable international context, conditioned by a relative decline of the US power, primarily in the economic sphere and, to a lesser extent, in the military sphere. This scenario of multipolarity creates tension and uncertainty in the peripheral countries when the issue of their foreign policy arises. This paper presents an analysis of the bilateral relations that were maintained by the Argentine Republic, a peripheral country, along with the United States and China during the period of 2005-2015 in matters of defense in order to identify the empirical consequences resulted from the Argentine actions. Based on the conceptual framework of Peripheral Realism, we analyze indicators related to the weapon trade, defense loans, joint exercises, and personnel training, among others. There will also be a comparative analysis of the conventional military forces of the two powers in question, United States and China. As a conclusion, the cost of having closer relations with China instead of the United States in the defense agenda has been clearly higher than the benefits obtained. The conclusions drawn are empirically aligned with the theoretical paradigm of peripheral realism. Although there are certain conceptual and methodological digressions, these conclusions they could be useful to update and adapt the theory to the current complex international scenario. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=China" title="China">China</a>, <a href="https://publications.waset.org/abstracts/search?q=United%20States" title=" United States"> United States</a>, <a href="https://publications.waset.org/abstracts/search?q=Argentine" title=" Argentine"> Argentine</a>, <a href="https://publications.waset.org/abstracts/search?q=peripheral%20country" title=" peripheral country"> peripheral country</a>, <a href="https://publications.waset.org/abstracts/search?q=peripheral%20realism" title=" peripheral realism"> peripheral realism</a> </p> <a href="https://publications.waset.org/abstracts/79272/bilateral-relations-in-matter-of-defense-between-argentina-united-states-and-argentina-china-along-the-period-2005-2015-advice-to-develop-a-rational-defense-foreign-policy-for-peripheral-countries" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/79272.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">379</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">438</span> Metachromatic Leukodystrophy: A Case Report</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mary%20Rose%20Eunice%20S.%20Gundayao">Mary Rose Eunice S. Gundayao</a>, <a href="https://publications.waset.org/abstracts/search?q=Manolo%20M.%20Fernandez"> Manolo M. Fernandez</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Metachromatic leukodystrophy (MLD) is a rare lysosomal storage disorder with an autosomal recessive inheritance pattern. Lysosomal storage disorders are often severe, follow a progressively neurodegenerative path, and may result in multi-organ failure, potentially leading to death within 5 to 6 years in cases of early-onset forms. There are limited data regarding cases of MLD in Filipino children. This is the case of a 2-year-old Filipino girl who presented with progressive neurological deterioration and was diagnosed with metachromatic leukodystrophy by molecular genetic testing. This case report aims to present this patient’s clinical history, neurological findings, diagnosis and novel genetic mutations causing MLD. A concise review of updated literature on MLD will be discussed. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=metachromatic%20leukodystrophy" title="metachromatic leukodystrophy">metachromatic leukodystrophy</a>, <a href="https://publications.waset.org/abstracts/search?q=ARSA%20gene" title=" ARSA gene"> ARSA gene</a>, <a href="https://publications.waset.org/abstracts/search?q=peripheral%20neuropathy" title=" peripheral neuropathy"> peripheral neuropathy</a>, <a href="https://publications.waset.org/abstracts/search?q=case%20report" title=" case report"> case report</a>, <a href="https://publications.waset.org/abstracts/search?q=demyelinating%20disease" title=" demyelinating disease"> demyelinating disease</a> </p> <a href="https://publications.waset.org/abstracts/191326/metachromatic-leukodystrophy-a-case-report" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/191326.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">19</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">437</span> Correlation between Peripheral Arterial Disease and Coronary Artery Disease in Bangladeshi Population: A Five Years Retrospective Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Syed%20Dawood%20M.%20Taimur">Syed Dawood M. Taimur</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Peripheral arterial disease (PAD) is under diagnosed in primary care practices, yet the extent of unrecognized PAD in patients with coronary artery disease (CAD) is unknown. Objective: To assess the prevalence of previously unrecognized PAD in patients undergoing coronary angiogram and to determine the relationship between the presence of PAD and severity of CAD. Material & Methods: This five years retrospective study was conducted at an invasive lab of the department of Cardiology, Ibrahim Cardiac Hospital & Research Institute from January 2010 to December 2014. Total 77 patients were included in this study. Study variables were age, sex, risk factors like hypertension, diabetes mellitus, dyslipidaemia, smoking habit and positive family history for ischemic heart disease, coronary artery and peripheral artery profile. Results: Mean age was 56.83±13.64 years, Male mean age was 53.98±15.08 years and female mean age was 54.5±1.73years. Hypertension was detected in 55.8%, diabetes in 87%, dyslipidaemia in 81.8%, smoking habits in 79.2% and 58.4% had a positive family history. After catheterization 88.3% had peripheral arterial disease and 71.4% had coronary artery disease. Out of 77 patients, 52 had both coronary and peripheral arterial disease which was statistically significant (p < .014). Coronary angiogram revealed 28.6% (22) patients had triple vessel disease, 23.3% (18) had single vessel disease, 19.5% (15) had double vessel disease and 28.6% (22) were normal coronary arteries. The peripheral angiogram revealed 54.5% had superficial femoral artery disease, 26% had anterior tibial artery disease, 27.3% had posterior tibial artery disease, 20.8% had common iliac artery disease, 15.6% had common femoral artery disease and 2.6% had renal artery disease. Conclusion: There is a strong and definite correlation between coronary and peripheral arterial disease. We found that cardiovascular risk factors were in fact risk factors for both PAD and CAD. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=coronary%20artery%20disease%20%28CAD%29" title="coronary artery disease (CAD)">coronary artery disease (CAD)</a>, <a href="https://publications.waset.org/abstracts/search?q=peripheral%20artery%20disease%28PVD%29" title=" peripheral artery disease(PVD)"> peripheral artery disease(PVD)</a>, <a href="https://publications.waset.org/abstracts/search?q=risk" title=" risk"> risk</a>, <a href="https://publications.waset.org/abstracts/search?q=factors" title=" factors"> factors</a>, <a href="https://publications.waset.org/abstracts/search?q=correlation" title=" correlation"> correlation</a>, <a href="https://publications.waset.org/abstracts/search?q=cathetarization" title=" cathetarization"> cathetarization</a> </p> <a href="https://publications.waset.org/abstracts/37628/correlation-between-peripheral-arterial-disease-and-coronary-artery-disease-in-bangladeshi-population-a-five-years-retrospective-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/37628.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">426</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">436</span> An Extremely Rare Anatomical Vascular Variant of Lower Limb Arterial System - Duplication of Superficial Femoral Artery</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Manik%20Sharma">Manik Sharma</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Understanding the anatomy and normal anatomical variations of the lower limb arterial system is undeniably important not only to understand the pathology involving the vessels of the lower limb but also as a part of endovascular intervention and surgical planning in cases that demand them as a part of treatment. There have been very few cases of duplication of SFA cited in the literature, close to six worldwide and this being the seventh case in the world and first to be reported in the Indian population. We incidentally came across this normal variant during US lower limb (US-LL) duplex scan in a patient with claudicating pain in bilateral lower limbs hence suspected of having peripheral vascular disease. It was confirmed on CT-Peripheral Angiography (CT-PA), which was done successively. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=peripheral%20vascular%20disease" title="peripheral vascular disease">peripheral vascular disease</a>, <a href="https://publications.waset.org/abstracts/search?q=claudicating%20pain" title=" claudicating pain"> claudicating pain</a>, <a href="https://publications.waset.org/abstracts/search?q=normal%20anatomical%20variants" title=" normal anatomical variants"> normal anatomical variants</a>, <a href="https://publications.waset.org/abstracts/search?q=endovascular%20intervention" title=" endovascular intervention"> endovascular intervention</a>, <a href="https://publications.waset.org/abstracts/search?q=duplication" title=" duplication"> duplication</a>, <a href="https://publications.waset.org/abstracts/search?q=CT-peripheral%20angiography" title=" CT-peripheral angiography"> CT-peripheral angiography</a>, <a href="https://publications.waset.org/abstracts/search?q=duplex%20scan" title=" duplex scan"> duplex scan</a>, <a href="https://publications.waset.org/abstracts/search?q=Iohexol" title=" Iohexol"> Iohexol</a> </p> <a href="https://publications.waset.org/abstracts/143749/an-extremely-rare-anatomical-vascular-variant-of-lower-limb-arterial-system-duplication-of-superficial-femoral-artery" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/143749.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">169</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">435</span> Dependency Theory on Examining the Relationship between the United States and the Middle East: In the Case of Iran, Saudi Arabia, and Turkey</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Abdelhafez%20Abdel%20Hafez">Abdelhafez Abdel Hafez</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Dependency theory was developed since 1950s, with economic concerns. It divided the world into two parts, the states of the peripheral (third world countries) and the states of the core (the developed capitalist countries). Another perspective developed to the theory with the implementation of the idea of semi-peripheral states in the new world order. With these divisions (core, peripheral, semi-peripheral) this study aims to develop a concept from the perspective of dependency theory, to understand the nature of the relationship of the U.S. with the Middle East Regions through its relation with Iran, Saudi Arabia, and Turkey. The tested countries (Saudi Arabia, Iran and Turkey) are seeking a foothold and influential role in the region. The paper argued that the U.S. directs its policies toward the region, in the way to guarantee no country of the region will be in semi-peripheral level (that could create competitions or danger on the U.S. interest). Therefore, U.S. policies in the region have varied from declaring war to diplomatic channels and sometimes ignoring. The paper is based on the dependency theory, and other international relations theories used to study the Middle East in the international context. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=dependency" title="dependency">dependency</a>, <a href="https://publications.waset.org/abstracts/search?q=hegemony" title=" hegemony"> hegemony</a>, <a href="https://publications.waset.org/abstracts/search?q=imperialism" title=" imperialism"> imperialism</a>, <a href="https://publications.waset.org/abstracts/search?q=middle%20east" title=" middle east"> middle east</a> </p> <a href="https://publications.waset.org/abstracts/127416/dependency-theory-on-examining-the-relationship-between-the-united-states-and-the-middle-east-in-the-case-of-iran-saudi-arabia-and-turkey" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/127416.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">129</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">434</span> Serum Granulocyte Colony Stimulating Factor is a Potent Stimulator of Hematopoeitic Progenitor Cells Mobilization in Trauma Hemorrhagic Shock</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Manoj%20Kumar">Manoj Kumar</a>, <a href="https://publications.waset.org/abstracts/search?q=Sujata%20Mohanty"> Sujata Mohanty</a>, <a href="https://publications.waset.org/abstracts/search?q=D.%20N.%20Rao"> D. N. Rao</a>, <a href="https://publications.waset.org/abstracts/search?q=Arul%20Selvi"> Arul Selvi</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanjeev%20K.%20Bhoi"> Sanjeev K. Bhoi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Hematopoietic progenitor cells (HPC) mobilized from bone marrow to peripheral blood has been observed in severe trauma and hemorrhagic shock patients. Granulocyte-colony stimulating factor (G-CSF) is a potent stimulator that mobilized HPC from bone marrow to peripheral blood. Objective: Our aim of the study was to investigate the serum G-CSF levels and correlate with HPC and outcome. Methods: Peripheral blood sample from 50 hemorrhagic shock patients was collected on arrival for determination of G-CSF and peripheral blood HPC (PBHPC) and compared with healthy control (n=15). Determination of serum levels of G-CSF by sandwich ELISA and PBHPC by Sysmex XE-2100. Data were categorized by age, sex, Injury Severity Score (ISS), and laboratory data was prospectively collected. Data are expressed as mean±SD and median (min, max). Results: Significantly increased the serum level of G-CSF (264.8 vs. 79.1 pg/ml) and peripheral blood HPC (0.1 vs. 0.01 %) in the T/HS patients when compared with control group. Conclusions: Our studies suggest serum G-CSF elevated in T/HS patients. The elevated in G-CSF was also associated with mobilization of HPC from BM to peripheral blood HPC. Increased the levels of G-CSF in T/HS may play a significant role in the alteration of the hematopoietic compartment. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=granulocyte%20colony%20stimulating%20factor" title="granulocyte colony stimulating factor">granulocyte colony stimulating factor</a>, <a href="https://publications.waset.org/abstracts/search?q=G-CSF" title=" G-CSF"> G-CSF</a>, <a href="https://publications.waset.org/abstracts/search?q=hematopoietic%20progenitor%20cells" title=" hematopoietic progenitor cells"> hematopoietic progenitor cells</a>, <a href="https://publications.waset.org/abstracts/search?q=HPC" title=" HPC"> HPC</a>, <a href="https://publications.waset.org/abstracts/search?q=trauma%20hemorrhagic%20shock" title=" trauma hemorrhagic shock"> trauma hemorrhagic shock</a>, <a href="https://publications.waset.org/abstracts/search?q=T%2FHS" title=" T/HS"> T/HS</a>, <a href="https://publications.waset.org/abstracts/search?q=outcome" title=" outcome"> outcome</a> </p> <a href="https://publications.waset.org/abstracts/33203/serum-granulocyte-colony-stimulating-factor-is-a-potent-stimulator-of-hematopoeitic-progenitor-cells-mobilization-in-trauma-hemorrhagic-shock" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/33203.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">332</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">433</span> Functional and Stimuli Implementation and Verification of Programmable Peripheral Interface (PPI) Protocol</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=N.%20N.%20Joshi">N. N. Joshi</a>, <a href="https://publications.waset.org/abstracts/search?q=G.%20K.%20Singh"> G. K. Singh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> We present the stimuli implementation and verification of a Programmable Peripheral Interface (PPI) 8255. It involves a designing and verification of configurable intellectual property (IP) module of PPI protocol using Verilog HDL for implementation part and System Verilog for verification. The overview of the PPI-8255 presented then the design specification implemented for the work following the functional description and pin configuration of PPI-8255. The coverage report of design shows that our design and verification environment covered 100% functionality in accordance with the design specification generated by the Questa Sim 10.0b. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Programmable%20Peripheral%20Interface%20%28PPI%29" title="Programmable Peripheral Interface (PPI)">Programmable Peripheral Interface (PPI)</a>, <a href="https://publications.waset.org/abstracts/search?q=verilog%20HDL" title=" verilog HDL"> verilog HDL</a>, <a href="https://publications.waset.org/abstracts/search?q=system%20verilog" title=" system verilog"> system verilog</a>, <a href="https://publications.waset.org/abstracts/search?q=questa%20sim" title=" questa sim "> questa sim </a> </p> <a href="https://publications.waset.org/abstracts/21194/functional-and-stimuli-implementation-and-verification-of-programmable-peripheral-interface-ppi-protocol" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/21194.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">522</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">432</span> Influence of Peripheral Vision Restrictions on the Walking Trajectory When Texting While Walking</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Macky%20Kato">Macky Kato</a>, <a href="https://publications.waset.org/abstracts/search?q=Takeshi%20Sato"> Takeshi Sato</a>, <a href="https://publications.waset.org/abstracts/search?q=Mizuki%20Nakajima"> Mizuki Nakajima</a> </p> <p class="card-text"><strong>Abstract:</strong></p> One major problem related to the use of smartphones is texting while simultaneously engaging in other things, resulting in serious road accidents. Apart from texting while driving being one of the most dangerous behaviors, texting while walking is also dangerous because it narrows the pedestrians’ field of vision. However, many of pedestrian text while walking very habitually. Smartphone users often overlook the potential harm associated with this behavior even while crossing roads. The successful texting while walking make them think that they are safe. The purpose of this study is to reveal of the influence of peripheral vision to the stability of walking trajectory with texting while walking. In total, 9 healthy male university students participated in the experiment. Their mean age was 21.4 years, and standard deviation was 0.7 years. They attempted to walk 10 m in three conditions. First one is the control (CTR) condition, with no phone and no restriction. The second one is the texting while walking (TWG) with no restrictions. The third one is restriction condition (PRS), with phone restricted by experimental peripheral goggles. The horizontal distances (HDS) and directions are measured as the scale of horizontal stability. The longitudinal distances (LDS) between the footprints were measured as the scale of the walking rhythm. The results showed that the HDS of the footprints from the straight line increased as the participants walked in the TWG and PRS conditions. In the PRS condition, this tendency was particularly remarkable. In addition, the LDS between the footprints decreased in the order of the CTR, TWG, and PRS conditions. The ANOVA results showed significant differences in the three conditions with respect to HDS. The differences among these conditions showed that the narrowing of the Pedestrian's vision because of smartphone use influences the walking trajectory and rhythm. It can be said that the pedestrians seem to use their peripheral vision marginally on texting while walking. Therefore, we concluded that the texting while walking narrows the peripheral vision so danger to increase the risk of the accidents. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=peripheral%20vision" title="peripheral vision">peripheral vision</a>, <a href="https://publications.waset.org/abstracts/search?q=stability" title=" stability"> stability</a>, <a href="https://publications.waset.org/abstracts/search?q=texting%20while%20walking" title=" texting while walking"> texting while walking</a>, <a href="https://publications.waset.org/abstracts/search?q=walking%20trajectory" title=" walking trajectory"> walking trajectory</a> </p> <a href="https://publications.waset.org/abstracts/77017/influence-of-peripheral-vision-restrictions-on-the-walking-trajectory-when-texting-while-walking" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/77017.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">257</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">431</span> Solitary Fibrous Tumor Presumed to Be a Peripheral Nerve Sheath Tumor Involving Right Branchial Plexus</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Daniela%20Proca">Daniela Proca</a>, <a href="https://publications.waset.org/abstracts/search?q=Yuan%20Rong"> Yuan Rong</a>, <a href="https://publications.waset.org/abstracts/search?q=Salvatore%20Luceno"> Salvatore Luceno</a>, <a href="https://publications.waset.org/abstracts/search?q=Jalil%20Nasibli"> Jalil Nasibli</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Solitary Fibrous Tumors (SFT) have many histologic mimickers and the only way to diagnose it, particularly in an unusual location, such as peripheral nerve trunks, is to use a comprehensive immunohistochemical staining panel. Monoclonal STAT6 immunostain is highly sensitive and specific for SFTs and particularly useful in the diagnosis of difficult SFT cases. Methods: We describe a solitary fibrous tumor (SFT) involving the right branchial plexus in a 66 yo female with 4-year history of slowly growing chest wall mass with recent dysesthesias in fingers 4th and 5th. MRI showed a well-circumscribed heterogenous mass measuring 5.4 x 3.8 x 4.0 cm and encircling peripheral nerves of the branchial plexus; no involvement of the bone or muscle was noted. A biopsy showed a bland spindled and epithelioid proliferation with no significant mitotic activity, no necrosis, and no atypia; peripheral nerve fascicles were encircled by the lesion. The main clinical and pathologic differential diagnosis included peripheral nerve sheath tumor, particularly schwannoma; HE microscopy didn’t show the classic Antoni A and B areas but showed focal subtle nuclear palisading, as well as prominent vessels with hyalinization. Immunohistochemical stains showed focal, weak cytoplasmic S100 positivity in the lesion; CD 34 and Vimentin were strongly and diffusely positive; the neoplastic cells were negative with AE1/AE3, EMA, CD31, SMA, Desmin, Calretinin, HMB-45, Melan A, PAX-8, NSE. The immunohistochemical and histologic pattern was not typical of peripheral nerve sheath tumor. On additional stains, the tumor was positive with STAT-6 and bcl-2 and focally positive with CD99. Given this profile, the final diagnosis was that of a solitary fibrous tumor. Results: NA Conclusion: Very few SFTs involving peripheral nerves and mimicking a peripheral nerve sheath tumor are described in the literature. Although histologically benign on this biopsy, long-term follow-up is required because of the risk of recurrence of these tumors and their uncertain biological behavior. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=solitary%20fibrous%20tumor" title="solitary fibrous tumor">solitary fibrous tumor</a>, <a href="https://publications.waset.org/abstracts/search?q=pathology" title=" pathology"> pathology</a>, <a href="https://publications.waset.org/abstracts/search?q=diagnosis" title=" diagnosis"> diagnosis</a>, <a href="https://publications.waset.org/abstracts/search?q=immunohistochemistry" title=" immunohistochemistry"> immunohistochemistry</a> </p> <a href="https://publications.waset.org/abstracts/141452/solitary-fibrous-tumor-presumed-to-be-a-peripheral-nerve-sheath-tumor-involving-right-branchial-plexus" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/141452.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">196</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">430</span> Reconnecting The Peripheral Wagons to the Euro Area Core Locomotive</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Igor%20Velickovski">Igor Velickovski</a>, <a href="https://publications.waset.org/abstracts/search?q=Aleksandar%20Stojkov"> Aleksandar Stojkov</a>, <a href="https://publications.waset.org/abstracts/search?q=Ivana%20Rajkovic"> Ivana Rajkovic</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This paper investigates drivers of shock synchronization using quarterly data for 27 European countries over the period 1999-2013 and taking into account the difference between core (‘the euro area core locomotive’) and peripheral euro area and transition countries (‘the peripheral wagons’). Results from panel error-correction models suggest that core of the euro area has not been strong magnetizer of the shock convergence of periphery and transition countries since the euro inception as a result of the offsetting effects of the various factors that affected the shock convergence process. These findings challenge the endogeneity hypothesis in the optimum currency area framework and rather support the specialisation paradigm which is concerning evidence for the future stability of the euro area. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=dynamic%20panel%20models" title="dynamic panel models">dynamic panel models</a>, <a href="https://publications.waset.org/abstracts/search?q=shock%20synchronisation" title=" shock synchronisation"> shock synchronisation</a>, <a href="https://publications.waset.org/abstracts/search?q=trade" title=" trade"> trade</a>, <a href="https://publications.waset.org/abstracts/search?q=optimum%20currency%20area" title=" optimum currency area"> optimum currency area</a> </p> <a href="https://publications.waset.org/abstracts/35361/reconnecting-the-peripheral-wagons-to-the-euro-area-core-locomotive" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/35361.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">358</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">429</span> Role of Hyperbaric Oxygen Therapy in Management of Diabetic Foot</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Magdy%20Al%20Shourbagi">Magdy Al Shourbagi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Diabetes mellitus is the commonest cause of neuropathy. The common pattern is a distal symmetrical sensory polyneuropathy, associated with autonomic disturbances. Less often, Diabetes mellitus is responsible for a focal or multifocal neuropathy. Common causes for non-healing of diabetic foot are the infection and ischemia. Diabetes mellitus is associated with a defective cellular and humoral immunity. Particularly, decreased phagocytosis, decreased chemotaxis, impaired bacterial killing and abnormal lymphocytic function resulting in a reduced inflammatory reaction and defective wound healing. Hyperbaric oxygen therapy is defined by the Undersea and Hyperbaric Medical Society as a treatment in which a patient intermittently breathes 100% oxygen and the treatment chamber is pressurized to a pressure greater than sea level (1 atmosphere absolute). The pressure increase may be applied in mono-place (single person) or multi-place chambers. Multi-place chambers are pressurized with air, with oxygen given via face mask or endotracheal tube; while mono-place chambers are pressurized with oxygen. Oxygen gas plays an important role in the physiology of wound healing. Hyperbaric oxygen therapy can raise tissue oxygen tensions to levels where wound healing can be expected. HBOT increases the killing ability of leucocytes also it is lethal for certain anaerobic bacteria and inhibits toxin formation in many other anaerobes. Multiple anecdotal reports and studies in HBO therapy in diabetic patients report that HBO can be an effective adjunct therapy in the management of diabetic foot wounds and is associated with better functional outcomes. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hyperbari%20oxygen%20therapy" title="hyperbari oxygen therapy">hyperbari oxygen therapy</a>, <a href="https://publications.waset.org/abstracts/search?q=diabetic%20foot" title=" diabetic foot"> diabetic foot</a>, <a href="https://publications.waset.org/abstracts/search?q=neuropathy" title=" neuropathy"> neuropathy</a>, <a href="https://publications.waset.org/abstracts/search?q=multiplace%20chambers" title=" multiplace chambers"> multiplace chambers</a> </p> <a href="https://publications.waset.org/abstracts/52781/role-of-hyperbaric-oxygen-therapy-in-management-of-diabetic-foot" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/52781.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">290</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">428</span> Autonomic Nervous System Changes Associated with Rheumatoid Arthritis: Clinical and Electrophysiological Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Emmanuel%20Kamal%20Aziz%20Saba">Emmanuel Kamal Aziz Saba</a>, <a href="https://publications.waset.org/abstracts/search?q=Hussein%20Al-Moghazy%20Sultan"> Hussein Al-Moghazy Sultan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The aim of this study was to evaluate clinically and electro physiologically the autonomic nervous system changes associated with rheumatoid arthritis (RA). The present study included 25 patients with RA [22 women (88%)] and 30 apparently healthy control subjects [27 women (90%)]. A thorough clinical examination was carried out. Disease activity and functional disability were assessed. Tests for assessment of autonomic functions include active and passive orthostatic stress tests, and sympathetic skin response (SSR). The presence of abnormality in 2 tests or more was a clue for the presence of autonomic neuropathy (AN). Sural sensory nerve conduction study and posterior tibial motor nerve conduction study were done. There was a statistically significant decrease in standing systolic and diastolic blood pressure (BP) components of the active orthostatic stress test and SSR amplitude as well as statistically significant prolongation of SSR latency of RA patients when compared to control. Three patients (12%) had clinical symptoms suggestive of AN; increased to 14 patients (56 %) when orthostatic stress tests and SSR were utilized. There were no statistically significant differences between patients with different disease activity score 28 with 4 variables grades of RA activity and SSR latency and amplitude. There were no statistically significant differences between patients with different Stanford Health Assessment Questionnaire Disability Index grades of RA functional disability and SSR latency and amplitude. In conclusion, autonomic neuropathy is a common extra-articular manifestation of RA affecting sympathetic and parasympathetic fibers. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=autonomic%20neuropathy" title="autonomic neuropathy">autonomic neuropathy</a>, <a href="https://publications.waset.org/abstracts/search?q=orthostatic%20stress%20test" title=" orthostatic stress test"> orthostatic stress test</a>, <a href="https://publications.waset.org/abstracts/search?q=rheumatoid%20arthritis" title=" rheumatoid arthritis"> rheumatoid arthritis</a>, <a href="https://publications.waset.org/abstracts/search?q=sympathetic%20skin%20response" title=" sympathetic skin response"> sympathetic skin response</a> </p> <a href="https://publications.waset.org/abstracts/30914/autonomic-nervous-system-changes-associated-with-rheumatoid-arthritis-clinical-and-electrophysiological-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/30914.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">359</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">427</span> Somatosensory-Evoked Blink Reflex in Peripheral Facial Palsy</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sarah%20Sayed%20El-%20Tawab">Sarah Sayed El- Tawab</a>, <a href="https://publications.waset.org/abstracts/search?q=Emmanuel%20Kamal%20Azix%20Saba"> Emmanuel Kamal Azix Saba</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objectives: Somatosensory blink reflex (SBR) is an eye blink response obtained from electrical stimulation of peripheral nerves or skin area of the body. It has been studied in various neurological diseases as well as among healthy subjects in different population. We designed this study to detect SBR positivity in patients with facial palsy and patients with post facial syndrome, to relate the facial palsy severity and the presence of SBR, and to associate between trigeminal BR changes and SBR positivity in peripheral facial palsy patients. Methods: 50 patients with peripheral facial palsy and post-facial syndrome 31 age and gender matched healthy volunteers were enrolled to this study. Facial motor conduction studies, trigeminal BR, and SBR were studied in all. Results: SBR was elicited in 67.7% of normal subjects, in 68% of PFS group, and in 32% of PFP group. On the non-paralytic side SBR was found in 28% by paralyzed side stimulation and in 24% by healthy side stimulation among PFP patients. For PFS group SBR was found on the non- paralytic side in 48%. Bilateral SBR elicitability was higher than its unilateral elicitability. Conclusion: Increased brainstem interneurons excitability is not essential to generate SBR. The hypothetical sensory-motor gating mechanism is responsible for SBR generation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=somatosensory%20evoked%20blink%20reflex" title="somatosensory evoked blink reflex">somatosensory evoked blink reflex</a>, <a href="https://publications.waset.org/abstracts/search?q=post%20facial%20syndrome" title=" post facial syndrome"> post facial syndrome</a>, <a href="https://publications.waset.org/abstracts/search?q=blink%20reflex" title=" blink reflex"> blink reflex</a>, <a href="https://publications.waset.org/abstracts/search?q=enchanced%20gain" title=" enchanced gain"> enchanced gain</a> </p> <a href="https://publications.waset.org/abstracts/18913/somatosensory-evoked-blink-reflex-in-peripheral-facial-palsy" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/18913.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">619</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">426</span> Design of Open Framework Based Smart ESS Profile for PV-ESS and UPS-ESS</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Young-Su%20Ryu">Young-Su Ryu</a>, <a href="https://publications.waset.org/abstracts/search?q=Won-Gi%20Jeon"> Won-Gi Jeon</a>, <a href="https://publications.waset.org/abstracts/search?q=Byoung-Chul%20Song"> Byoung-Chul Song</a>, <a href="https://publications.waset.org/abstracts/search?q=Jae-Hong%20Park"> Jae-Hong Park</a>, <a href="https://publications.waset.org/abstracts/search?q=Ki-Won%20Kwon"> Ki-Won Kwon</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this paper, an open framework based smart energy storage system (ESS) profile for photovoltaic (PV)-ESS and uninterruptible power supply (UPS)-ESS is proposed and designed. An open framework based smart ESS is designed and developed for unifying the different interfaces among manufacturers. The smart ESS operates under the profile which provides the specifications of peripheral devices such as different interfaces and to the open framework. The profile requires well systemicity and expandability for addible peripheral devices. Especially, the smart ESS should provide the expansion with existing systems such as UPS and the linkage with new renewable energy technology such as PV. This paper proposes and designs an open framework based smart ESS profile for PV-ESS and UPS-ESS. The designed profile provides the existing smart ESS and also the expandability of additional peripheral devices on smart ESS such as PV and UPS. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=energy%20storage%20system%20%28ESS%29" title="energy storage system (ESS)">energy storage system (ESS)</a>, <a href="https://publications.waset.org/abstracts/search?q=open%20framework" title=" open framework"> open framework</a>, <a href="https://publications.waset.org/abstracts/search?q=profile" title=" profile"> profile</a>, <a href="https://publications.waset.org/abstracts/search?q=photovoltaic%20%28PV%29" title=" photovoltaic (PV)"> photovoltaic (PV)</a>, <a href="https://publications.waset.org/abstracts/search?q=uninterruptible%20power%20supply%20%28UPS%29" title=" uninterruptible power supply (UPS)"> uninterruptible power supply (UPS)</a> </p> <a href="https://publications.waset.org/abstracts/68041/design-of-open-framework-based-smart-ess-profile-for-pv-ess-and-ups-ess" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/68041.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">474</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">425</span> Ophthalmic Hashing Based Supervision of Glaucoma and Corneal Disorders Imposed on Deep Graphical Model</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=P.%20S.%20Jagadeesh%20Kumar">P. S. Jagadeesh Kumar</a>, <a href="https://publications.waset.org/abstracts/search?q=Yang%20Yung"> Yang Yung</a>, <a href="https://publications.waset.org/abstracts/search?q=Mingmin%20Pan"> Mingmin Pan</a>, <a href="https://publications.waset.org/abstracts/search?q=Xianpei%20Li"> Xianpei Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Wenli%20Hu"> Wenli Hu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Glaucoma is impelled by optic nerve mutilation habitually represented as cupping and visual field injury frequently with an arcuate pattern of mid-peripheral loss, subordinate to retinal ganglion cell damage and death. Glaucoma is the second foremost cause of blindness and the chief cause of permanent blindness worldwide. Consequently, all-embracing study into the analysis and empathy of glaucoma is happening to escort deep learning based neural network intrusions to deliberate this substantial optic neuropathy. This paper advances an ophthalmic hashing based supervision of glaucoma and corneal disorders preeminent on deep graphical model. Ophthalmic hashing is a newly proposed method extending the efficacy of visual hash-coding to predict glaucoma corneal disorder matching, which is the faster than the existing methods. Deep graphical model is proficient of learning interior explications of corneal disorders in satisfactory time to solve hard combinatoric incongruities using deep Boltzmann machines. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=corneal%20disorders" title="corneal disorders">corneal disorders</a>, <a href="https://publications.waset.org/abstracts/search?q=deep%20Boltzmann%20machines" title=" deep Boltzmann machines"> deep Boltzmann machines</a>, <a href="https://publications.waset.org/abstracts/search?q=deep%20graphical%20model" title=" deep graphical model"> deep graphical model</a>, <a href="https://publications.waset.org/abstracts/search?q=glaucoma" title=" glaucoma"> glaucoma</a>, <a href="https://publications.waset.org/abstracts/search?q=neural%20networks" title=" neural networks"> neural networks</a>, <a href="https://publications.waset.org/abstracts/search?q=ophthalmic%20hashing" title=" ophthalmic hashing"> ophthalmic hashing</a> </p> <a href="https://publications.waset.org/abstracts/78678/ophthalmic-hashing-based-supervision-of-glaucoma-and-corneal-disorders-imposed-on-deep-graphical-model" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/78678.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">250</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=peripheral%20neuropathy&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=peripheral%20neuropathy&page=3">3</a></li> <li class="page-item"><a class="page-link" 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