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}) })(jQuery); </script> </head> <body class="post-template-default single single-post postid-938 single-format-standard header-image full-width-content genesis-breadcrumbs-visible"><div class="site-container"><header class="site-header"><div class="wrap"><div class="title-area"><p class="site-title"><a href="https://www.thermofisher.com/" title="Thermo Fisher Scientific">Thermo Fisher Scientific</a></p><p class="site-description">Electron and cryo-electron microscopy stories and solutions about the advancement of cellular and structural biology</p></div><div class="widget-area header-widget-area"><section id="block-5" class="widget widget_block"><div class="widget-wrap"> <div class="wp-block-group"><div class="wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow"></div></div> </div></section> <section id="block-6" class="widget widget_block"><div class="widget-wrap"> <div class="wp-block-group"><div class="wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow"></div></div> </div></section> </div><div class="breadcrumb"><span class="breadcrumb-link-wrap"><a href="https://www.thermofisher.com/blog/?">Accelerating Science</a></span><span class="breadcrumb-link-wrap"><a class="breadcrumb-link" href="https://www.thermofisher.com/blog/atomic-resolution/"><span class="breadcrumb-link-text-wrap">Life in Atomic Resolution</span></a><meta ></span> <span aria-label="breadcrumb separator">/</span> <span class="breadcrumb-link-wrap"><a class="breadcrumb-link" href="https://www.thermofisher.com/blog/atomic-resolution/cryo-electron-microscopy-cryo-em/"><span class="breadcrumb-link-text-wrap">Cryo-Electron Microscopy (Cryo-EM)</span></a><meta ></span> <span aria-label="breadcrumb separator">/</span> <span class="breadcrumb-current-title">Thermo Fisher Scientific Hits the Road to Showcase Simplified Cryo-TEM</span></div></div></header><div class="site-inner"><div class="content-sidebar-wrap"><main class="content"><article class="post-938 post type-post status-publish format-standard has-post-thumbnail category-cryo-electron-microscopy-cryo-em category-general tag-cryo-electron-microscopy tag-cryo-em tag-cryo-em-single-particle-analysis tag-tem tag-transmission-electron-microscope entry" aria-label="Thermo Fisher Scientific Hits the Road to Showcase Simplified Cryo-TEM"><header class="entry-header"><h1 class="entry-title">Thermo Fisher Scientific Hits the Road to Showcase Simplified Cryo-TEM</h1> <span class="post-info-author"> By <a href="https://www.thermofisher.com/blog/author/mhowie/" title="Posts by Mike Howie" rel="author">Mike Howie</a> </span> <span class="post-info-date"> 12.19.2022 </span> </header><div class="entry-content"><p>During the fall semester, we visited colleges and institutions around the United States to showcase the <a href="https://ter.li/4s2ch7">Thermo Scientific Tundra Cryo-Transmission Electron Microscope</a> (Cryo-TEM). Designed for expert microscopists and newcomers alike, the Tundra Cryo-TEM makes it <a href="https://www.thermofisher.com/blog/atomic-resolution/tundra-cryo-tem-questions/">easy to bring structural analysis in house</a>, offering faster sample loading and unloading and a simpler workflow for cryo-EM data collection.</p> <p><img decoding="async" class="aligncenter size-large wp-image-934" src="https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2021/09/Tundra-Roadshow-recap-1920脳1080-1024x576.png" alt="Thermo Fisher Scientific Tundra Cryo-TEM workshops" width="760" height="428" srcset="https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2021/09/Tundra-Roadshow-recap-1920脳1080-1024x576.png 1024w, https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2021/09/Tundra-Roadshow-recap-1920脳1080-300x169.png 300w, https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2021/09/Tundra-Roadshow-recap-1920脳1080-768x432.png 768w, https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2021/09/Tundra-Roadshow-recap-1920脳1080-1536x864.png 1536w, https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2021/09/Tundra-Roadshow-recap-1920脳1080.png 1920w" sizes="(max-width: 760px) 100vw, 760px" /></p> <p>Through a remote live demo via the Thermo Fisher Scientific NanoPort, attendees got a first-hand look at how easy it can be to obtain structures at biologically relevant resolutions and prepare samples for analysis on more powerful transmission electron microscopy systems like the Thermo Scientific <a href="https://ter.li/sr9gh1">Krios</a> and <a href="https://ter.li/secd5s">Glacios</a> Cryo-TEMs.</p> <p><strong><em><a href="https://ter.li/i9ocfo">Watch our on-demand webinar for a closer look at the Tundra Cryo-TEM</a> >></em></strong></p> <h2 style="font-size: 100%"><strong>Streamlining structural biology research with cryo-TEM</strong></h2> <p>At each stop we shared how the Tundra Cryo-TEM can help optimize biological samples鈥攁 difficult task that can lead to a variety of problems and that is often a bottleneck in the cryo-electron microscopy workflow. For example, when a grid is glow discharged, very few oligomeric protein complex particles can be observed. But by altering the time and the strength of the plasma treatment, users can dramatically alter the particle distribution鈥攁 difference that鈥檚 easy to see with TEM imaging.</p> <div id="attachment_947" style="width: 946px" class="wp-caption aligncenter"><img decoding="async" aria-describedby="caption-attachment-947" class="wp-image-947 size-full" src="https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2022/12/tundraworkshops1.png" alt="Differences in particle distribution resulting from different plasma treatments captured on Tundra Cryo-TEM" width="936" height="470" srcset="https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2022/12/tundraworkshops1.png 936w, https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2022/12/tundraworkshops1-300x151.png 300w, https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2022/12/tundraworkshops1-768x386.png 768w" sizes="(max-width: 936px) 100vw, 936px" /><p id="caption-attachment-947" class="wp-caption-text">Differences in particle distribution resulting from different plasma treatments. Images created on a Tundra Cryo-TEM. Drulyte et. al. 2018, Acta Crystallographica Section D: Structural Biology</p></div> <p>Similarly, the Tundra Cryo-TEM has been used to help optimize the expression and purification systems for AAV, which are used in gene therapy to package and deliver the intended genes to patients. A micrograph and 3D classes created with the instrument clearly show full and empty populations, helping researchers understand how to increase the percentage of full particles and ultimately create more effective treatments.</p> <div id="attachment_948" style="width: 946px" class="wp-caption aligncenter"><img loading="lazy" decoding="async" aria-describedby="caption-attachment-948" class="size-full wp-image-948" src="https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2022/12/Tundra-workshops-2.png" alt="Tundra Cryo-TEM micrographs of AAV - from 2022 workshops" width="936" height="498" srcset="https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2022/12/Tundra-workshops-2.png 936w, https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2022/12/Tundra-workshops-2-300x160.png 300w, https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2022/12/Tundra-workshops-2-768x409.png 768w" sizes="(max-width: 936px) 100vw, 936px" /><p id="caption-attachment-948" class="wp-caption-text">Micrograph and 3D classes of AAV created with the Tundra Cryo-TEM.</p></div> <h2 style="font-size: 100%"><strong>Simplifying the workflow with automated imaging </strong></h2> <div id="attachment_982" style="width: 410px" class="wp-caption alignright"><img loading="lazy" decoding="async" aria-describedby="caption-attachment-982" class="wp-image-982" src="https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2022/12/MicrosoftTeams-image-5.jpg" alt="Thermo Scientific Tundra Workshop at Emory University" width="400" height="533" srcset="https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2022/12/MicrosoftTeams-image-5.jpg 768w, https://www.thermofisher.com/blog/atomic-resolution/wp-content/uploads/sites/22/2022/12/MicrosoftTeams-image-5-225x300.jpg 225w" sizes="(max-width: 400px) 100vw, 400px" /><p id="caption-attachment-982" class="wp-caption-text">Thermo Scientific Tundra Workshop at Emory University</p></div> <p>These demonstrations highlighted not only the results that the Tundra Cryo-TEM can deliver but also how it simplifies the TEM imaging workflow. The system features a new, semi-automated loader that makes it possible to load and unload samples in less than 10 minutes, allowing for an iterative way of working. It uses the same Autogrids that are compatible with the Krios and Glacios Cryo-TEMs, making it easier to switch between the instruments. And it delivers instant feedback on biochemistry adjustments鈥攆aster than other technologies.</p> <p>The AI-guided automation makes operation easy for all users鈥攜ears of experience are no longer needed to perform transmission electron microscopy. Guided alignment helps researchers load and run the instrument, and the user-friendly interface automates data collection. The intuitive traffic lights panel indicates and helps to correct any issues. AI decision making adjusts the system automatically, finding and focusing on areas of the grid that will produce usable data. And the system analyzes intermediate results on the fly to provide instant user feedback and steer data collection.</p> <p>When surveyed about their previous experience in cryo-EM, almost half of attendee respondents shared that they鈥檙e just getting started with the technique, and 86% said they鈥檙e most compelled by the Tundra Cryo-TEM’s overall ease-of-use.</p> <p>With a simplified workflow, the Thermo Scientific Tundra Cryo-TEM can help scientists bring structural biology into their labs to help answer some of their most challenging research questions quickly and at an affordable price point.</p> <p><strong><a href="https://ter.li/i9ocfo">Watch our Getting Started in Cryo-EM webinar to learn more about the Tundra Cryo-TEM and see how it can fit in your lab</a> >></strong></p> <p><a href="https://ter.li/3eej7j"><img loading="lazy" decoding="async" class="aligncenter size-full wp-image-1336" 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