Bioscience | NIST

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<source srcset="/sites/default/files/styles/300w_x_180h/public/images/2020/11/05/bigstock-177254398.jpg.webp?itok=Nnof47Bq 1x, /sites/default/files/styles/600w_x_360h/public/images/2020/11/05/bigstock-177254398.jpg.webp?itok=Rv82YcGK 2x" media="(min-width: 0px)" type="image/webp" width="300" height="180"/> <img loading="eager" src="/sites/default/files/styles/600w_x_360h/public/images/2020/11/05/bigstock-177254398.jpg.jpg?itok=Rv82YcGK" width="600" height="360" alt="GenomeEditingConsortium" title="GenomeEditingConsortium" typeof="foaf:Image" /> </picture> </a> </div> <div class="nist-hero__caption"> <a href="/programs-projects/nist-genome-editing-consortium"> <div class="text">NIST Genome Editing Consortium</div> </a> </div> </div> </div> <div class="nist-hero__item tablet:grid-col-6 "> <div class="nist-hero__item-inner"> <div class="nist-hero__image"> <a href="https://www.niimbl.org/"> <picture> <source srcset="/sites/default/files/styles/600w_x_360h/public/images/2021/07/14/NIIMBL%20-%20Fermentation%20lab%20-%2030%5B9%5D.jpg.webp?itok=UxfjBf5U 1x, /sites/default/files/styles/1200w_x_720h/public/images/2021/07/14/NIIMBL%20-%20Fermentation%20lab%20-%2030%5B9%5D.jpg.webp?itok=qbK56byP 2x" media="(min-width: 480px)" type="image/webp" width="600" height="360"/> <source srcset="/sites/default/files/styles/300w_x_180h/public/images/2021/07/14/NIIMBL%20-%20Fermentation%20lab%20-%2030%5B9%5D.jpg.webp?itok=MlhUmyNF 1x, /sites/default/files/styles/600w_x_360h/public/images/2021/07/14/NIIMBL%20-%20Fermentation%20lab%20-%2030%5B9%5D.jpg.webp?itok=UxfjBf5U 2x" media="(min-width: 0px)" type="image/webp" width="300" height="180"/> <img loading="eager" src="/sites/default/files/styles/600w_x_360h/public/images/2021/07/14/NIIMBL%20-%20Fermentation%20lab%20-%2030%5B9%5D.jpg.jpg?itok=UxfjBf5U" width="600" height="360" alt="Two people in coveralls and hair covers check the readouts on laboratory equipment." typeof="foaf:Image" /> </picture> </a> </div> <div class="nist-hero__caption"> <a href="https://www.niimbl.org/"> <div class="text">National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL)</div> </a> </div> </div> </div> </div> </div> </div> <div class="text-with-summary margin-bottom-5"> <p>NIST provides measurement assurance for the biotechnology industry through the development of quantitative analytical measurement tools for nucleic acids, proteins, metabolites, and cell systems to aid industry in the deployment of innovative biotechnologies and advanced biomaterials.</p><p>NIST standards and reference materials underpin advances in bioscience and biotechnology, contributing to human health and the U.S. economy.</p><p>NIST provides: </p><ul><li>Quantitative measurements</li><li>Reference materials for quality control</li><li>Data for benchmarking</li><li>Leadership and technical advice for U.S. and international standards development efforts</li></ul><p>We have specialized expertise in and equipment for measuring biological processes and systems, along with experience in managing the large amounts of data these measurements produce. Our work benefits: </p><ul><li>Clinical medicine</li><li>The biopharmaceutical industry</li><li>Regulatory agencies</li><li>The DNA forensics community</li><li>The mass spectrometry community</li><li>The synthetic biology industry</li><li>Equipment manufacturers</li></ul><h2 class="nist-block__title">The NIST Biofoundry</h2><figure class=" align-center nist-video" role="group"> <div data-media-id="528566"> <div class="video-embed-field"><div class="video-embed-field-lazy" data-video-embed-field-lazy="<div class="video-embed-field-provider-nist-kaltura video-embed-field-responsive-video"><iframe width="854" height="480" frameborder="0" allow="autoplay *; fullscreen *; encrypted-media *" allowfullscreen="allowfullscreen" src="https://www.kaltura.com/p/684682/sp/68468200/embedIframeJs/uiconf_id/31013851/partner_id/684682?iframeembed=true&amp;entry_id=0_ap1sg96i?iframeembed=true&amp;entry_id=0_ap1sg96i&amp;flashvars%5BautoPlay%5D=1"></iframe> </div> "><img alt="NIST Living Measurement Systems Foundry" loading="lazy" src="https://cdnsecakmi.kaltura.com/p/684682/sp/68468200/thumbnail/entry_id/0_ap1sg96i/width/1280" typeof="foaf:Image"> <button class="video-embed-field-lazy-play"></button> <div class="video-embed-field-lazy-title">NIST Living Measurement Systems Foundry</div> </div> </div> </div> <figcaption class="nist-image__caption">The NIST Living Measurement Systems Foundry is enabling reliable, scalable, and safe engineering of cells that can sense and respond in controlled ways for applications such as living therapeutics, environmental remediation, and structured materials fabrication. This automated facility combines high throughput measurements and machine learning to create rapid design-build-test-learn cycles for cellular engineering. For more info: <a href="https://go.usa.gov/xmdkw">https://go.usa.gov/xmdkw</a></figcaption> </figure> <h2 class="nist-block__title">Key Accomplishments</h2><ul><li><a href="https://www.nist.gov/industry-impacts/accuracy-genetic-testing-technologies">DNA reference materials</a> accelerate product development and provide quality assurance to clinical test labs and manufacturers.</li><li>NIST expertise in genetic testing supports <a href="https://www.nist.gov/programs-projects/cancer-biomarker-reference-materials">cancer precision medicine</a> and <a href="https://www.nist.gov/programs-projects/dna-biometrics">forensic applications</a>.</li><li>The <a href="https://www.nist.gov/programs-projects/nist-genome-editing-consortium">NIST Genome Editing Consortium</a> addresses the measurements and standards needed to increase confidence and lower the risk of using genome editing technologies in research and commercial products.</li><li>The NIST monoclonal antibody reference material — <a href="https://www.nist.gov/news-events/news/2016/07/extraordinary-standard-new-nist-protein-could-spur-biopharmaceutical">the NISTmAb</a> — is used by biopharmaceutical firms for quality assurance and to evaluate new biomanufacturing methods and tools. </li><li>Facilities such as the <a href="https://www.nist.gov/ncnr">NIST Center for Neutron Research</a> help industry members develop the expertise to use rare neutron scattering tools. Leading biotech companies such as Genentech, Amgen, Regeneron and Pfizer are part of the <a href="https://www.nist.gov/nsoft">nSoft consortium</a>, using neutron science to explore protein-based pharmaceuticals produced by living cells. </li><li>In addition, NIST provides matched funds to the <a href="https://niimbl.force.com/s/">National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL)</a>, part of the <a href="https://www.manufacturingusa.com/">Manufacturing USA</a> network, and participates in activities of Manufacturing USA’s <a href="https://www.armiusa.org/">BioFabUSA</a>, dedicated to advancing regenerative medicine. </li></ul> </div> <div class="nist-block" > <div class="margin-y-4"> <h2 class="nist-block__title"> <div class="string">Feature Stories and Blogs</div> </h2> <div class="grid-row grid-gap-2"> <div class="nist-card tablet:grid-col-4 "> <div class="nist-card__inner"> <div class="nist-card__image"> <a href="/feature-stories/safe-efficient-reliable-new-science-fight-against-killer-drugs"> <div class="entity-reference"> <a href="/feature-stories/safe-efficient-reliable-new-science-fight-against-killer-drugs" hreflang="en"><img loading="lazy" src="/sites/default/files/styles/400_x_250_focal_point/public/images/2021/03/18/Faux_Fentynal_lethal_dose_005.jpg?itok=Gblgv4aW" width="400" height="250" alt="Black background. 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Next to the penny is a tiny amount of a white powder." typeof="foaf:Image" /> </a> </div> </a> </div> <div class="nist-card__title padding-y-5"> <h3><span>Safe, Efficient, Reliable: New Science in the Fight Against Killer Drugs</span> </h3> </div> <div class="nist-card__links"> <div class="nist-card__button"> <a href="/feature-stories/safe-efficient-reliable-new-science-fight-against-killer-drugs" class="usa-button ">Read more</a> </div> </div> </div> </div> <div class="nist-card tablet:grid-col-4 "> <div class="nist-card__inner"> <div class="nist-card__image"> <a href="/blogs/taking-measure/sinking-our-teeth-science-how-biomedical-engineering-can-help-make-us-healthier"> <div class="entity-reference"> <a href="/blogs/taking-measure/sinking-our-teeth-science-how-biomedical-engineering-can-help-make-us-healthier" hreflang="en"><img loading="lazy" src="/sites/default/files/styles/400_x_250_focal_point/public/images/2024/08/21/robert_gutierrez_lab_fridge.jpg?itok=2bhMU25M" width="400" height="250" alt="A researcher wearing safety gear kneels at the open door of a lab fridge, displaying a tray of samples. " typeof="foaf:Image" /> </a> </div> </a> </div> <div class="nist-card__title padding-y-5"> <h3><span>Sinking Our Teeth Into Science: How Biomedical Engineering Can Help Make Us Healthier</span> </h3> </div> <div class="nist-card__links"> <div class="nist-card__button"> <a href="/blogs/taking-measure/sinking-our-teeth-science-how-biomedical-engineering-can-help-make-us-healthier" class="usa-button ">Read more</a> </div> </div> </div> </div> <div class="nist-card tablet:grid-col-4 "> <div class="nist-card__inner"> <div class="nist-card__image"> <a href="/blogs/taking-measure/promise-synthetic-cells-revolutionary-new-drugs-outer-space-explorers-and"> <div class="entity-reference"> <a href="/blogs/taking-measure/promise-synthetic-cells-revolutionary-new-drugs-outer-space-explorers-and" hreflang="en"><img loading="lazy" src="/sites/default/files/styles/400_x_250_focal_point/public/images/2020/03/11/DSC_0935_full.jpg?itok=OF6t1fKw" width="400" height="250" alt="NIST researchers Elizabeth Strychalski and David Ross program the robotic arm that operates within the box-like structure of the NIST biofoundry." typeof="foaf:Image" /> </a> </div> </a> </div> <div class="nist-card__title padding-y-5"> <h3><span>The Promise of Synthetic Cells: Revolutionary New Drugs, Outer Space Explorers and Pushing Beyond the Limits of Evolution</span> </h3> </div> <div class="nist-card__links"> <div class="nist-card__button"> <a href="/blogs/taking-measure/promise-synthetic-cells-revolutionary-new-drugs-outer-space-explorers-and" class="usa-button ">Read more</a> </div> </div> </div> </div> </div> </div> <div class="margin-y-4"> <h2 class="nist-block__title">News</h2> <div class="paragraph paragraph--type--dynamic-news-list-topic paragraph--view-mode--default"> <div class="views-element-container"><div class="js-view-dom-id-c6177283247e7e7355849d590c5ceaedf6ab4690ff83aa76811b00f89052b91e"> <div class="grid-row grid-gap-2"> <div class="nist-card tablet:grid-col-4 nist-card--topic "> <div 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