<?xml version="1.0" encoding="UTF-8"?> <article key="pdf/10003034" mdate="2015-10-01 00:00:00"> <author>Amer A. Hasan and Mehri Igci and Ersin Borazan and Rozhgar A. Khailany and Emine Bayraktar and Ahmet Arslan</author> <title>DownRegulated Gene Expression of GKN1 and GKN2 as Diagnostic Markers for Gastric Cancer</title> <pages>532 - 535</pages> <year>2015</year> <volume>9</volume> <number>6</number> <journal>International Journal of Medical and Health Sciences</journal> <ee>https://publications.waset.org/pdf/10003034</ee> <url>https://publications.waset.org/vol/102</url> <publisher>World Academy of Science, Engineering and Technology</publisher> <abstract>Gastric Cancer (GC) has high morbidity and fatality rate in various countries. It is still one of the most frequent and deadly diseases. Gastrokine1 (GKN1) and gastrokine2 (GKN2) genes are highly expressed in the normal stomach epithelium and play important roles in maintaining the integrity and homeostasis of stomach mucosal epithelial cells. In this study, 47 paired samples that were grouped according to the types of gastric cancer and the clinical characteristics of the patients, including gender and average of age. They were investigated with gene expression analysis and mutation screening by monitoring RTPCR, SSCP and nucleotide sequencing techniques. Both GKN1 and GKN2 genes were observed significantly reduced found by (Wilcoxon signed rank test; p</abstract> <index>Open Science Index 102, 2015</index> </article>