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release</title> <meta name="description" content="Search results for: controlled release"> <meta name="keywords" content="controlled release"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="controlled release"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 3477</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: controlled release</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3477</span> Preparation and Evaluation of Multiple Unit Tablets of Aceclofenac</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Vipin%20Saini">Vipin Saini</a>, <a href="https://publications.waset.org/abstracts/search?q=Sunil%20Kamboj"> Sunil Kamboj</a>, <a href="https://publications.waset.org/abstracts/search?q=Suman%20Bala"> Suman Bala</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Pandurangan"> A. Pandurangan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The present research is aimed at fabrication of multiple-unit controlled-release tablet formulation of aceclofenac by employing acrylic polymers as the release controlling excipients for drug multi-particulates to achieve the desired objectives of maintaining the same controlled release characteristics as that prior to their compression into tablet. Various manufacturers are successfully manufacturing and marketing aceclofenac controlled release tablet by applying directly coating materials on the tablet. The basic idea behind development of such formulations was to employ aqueous acrylics polymers dispersion as an alternative to the existing approaches, wherein the forces of compression may cause twist of drug pellets, but do not have adverse effects on the drug release properties. Thus, the study was undertaken to illustrate manufacturing of controlled release aceclofenac multiple-unit tablet formulation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=aceclofenac" title="aceclofenac">aceclofenac</a>, <a href="https://publications.waset.org/abstracts/search?q=multiple-unit%20tablets" title=" multiple-unit tablets"> multiple-unit tablets</a>, <a href="https://publications.waset.org/abstracts/search?q=acrylic%20polymers" title=" acrylic polymers"> acrylic polymers</a>, <a href="https://publications.waset.org/abstracts/search?q=controlled-release" title=" controlled-release"> controlled-release</a> </p> <a href="https://publications.waset.org/abstracts/1518/preparation-and-evaluation-of-multiple-unit-tablets-of-aceclofenac" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/1518.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">442</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3476</span> Effect of Swelling Pressure on Drug Release from Polyelectrolyte Micro-Hydrogel Particles</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mina%20Boroujerdi">Mina Boroujerdi</a>, <a href="https://publications.waset.org/abstracts/search?q=Javad%20Tavakoli"> Javad Tavakoli</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Hydrogels are extensively studied as matrices for the controlled release of drugs. To evaluate the mobility of embedded molecules, these drug delivery systems are usually characterized by release studies. In this contribution, an electronic device for swelling pressure measurement during drug release from hydrogel network was developed. Also, poly acrylic acid micro particles were prepared for prolonged and sustained controlled acetaminophen release. Effect of swelling pressure on drug release from micro particles studied under different environment pH in order to predict release profile in gastro-intestine medium. Swelling ratio and swelling pressure were measured in different pH. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=swelling%20pressure" title="swelling pressure">swelling pressure</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20delivery" title=" drug delivery"> drug delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrogel" title=" hydrogel"> hydrogel</a>, <a href="https://publications.waset.org/abstracts/search?q=polyelectrolyte" title=" polyelectrolyte"> polyelectrolyte</a> </p> <a href="https://publications.waset.org/abstracts/54759/effect-of-swelling-pressure-on-drug-release-from-polyelectrolyte-micro-hydrogel-particles" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/54759.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">299</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3475</span> Controlled Release of Glucosamine from Pluronic-Based Hydrogels for the Treatment of Osteoarthritis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Papon%20Thamvasupong">Papon Thamvasupong</a>, <a href="https://publications.waset.org/abstracts/search?q=Kwanchanok%20Viravaidya-Pasuwat"> Kwanchanok Viravaidya-Pasuwat</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Osteoarthritis affects a lot of people worldwide. Local injection of glucosamine is one of the alternative treatment methods to replenish the natural lubrication of cartilage. However, multiple injections can potentially lead to possible bacterial infection. Therefore, a drug delivery system is desired to reduce the frequencies of injections. A hydrogel is one of the delivery systems that can control the release of drugs. Thermo-reversible hydrogels can be beneficial to the drug delivery system especially in the local injection route because this formulation can change from liquid to gel after getting into human body. Once the gel is in the body, it will slowly release the drug in a controlled manner. In this study, various formulations of Pluronic-based hydrogels were synthesized for the controlled release of glucosamine. One of the challenges of the Pluronic controlled release system is its fast dissolution rate. To overcome this problem, alginate and calcium sulfate (CaSO<sub>4</sub>) were added to the polymer solution. The characteristics of the hydrogels were investigated including the gelation temperature, gelation time, hydrogel dissolution and glucosamine release mechanism. Finally, a mathematical model of glucosamine release from Pluronic-alginate-hyaluronic acid hydrogel was developed. Our results have shown that crosslinking Pluronic gel with alginate did not significantly extend the dissolution rate of the gel. Moreover, the gel dissolution profiles and the glucosamine release mechanisms were best described using the zeroth-order kinetic model, indicating that the release of glucosamine was primarily governed by the gel dissolution. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=controlled%20release" title="controlled release">controlled release</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20delivery%20system" title=" drug delivery system"> drug delivery system</a>, <a href="https://publications.waset.org/abstracts/search?q=glucosamine" title=" glucosamine"> glucosamine</a>, <a href="https://publications.waset.org/abstracts/search?q=pluronic" title=" pluronic"> pluronic</a>, <a href="https://publications.waset.org/abstracts/search?q=thermoreversible%20hydrogel" title=" thermoreversible hydrogel"> thermoreversible hydrogel</a> </p> <a href="https://publications.waset.org/abstracts/51314/controlled-release-of-glucosamine-from-pluronic-based-hydrogels-for-the-treatment-of-osteoarthritis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/51314.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">270</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3474</span> Development and Characterization of Controlled Release Photo Cross-Linked Implants for Ocular Delivery of Triamcinolone Acetonide</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ravi%20Sheshala">Ravi Sheshala</a>, <a href="https://publications.waset.org/abstracts/search?q=Annie%20Lee"> Annie Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Ai%20Lin%20Ong"> Ai Lin Ong</a>, <a href="https://publications.waset.org/abstracts/search?q=Ling%20Ling%20Cheu"> Ling Ling Cheu</a>, <a href="https://publications.waset.org/abstracts/search?q=Thiagarajan%20Madheswaran"> Thiagarajan Madheswaran</a>, <a href="https://publications.waset.org/abstracts/search?q=Thankur%20R.%20R.%20Singh"> Thankur R. R. Singh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The objectives of the present research work were to develop and characterize biodegradable controlled release photo cross-linked implants of Triamcinolone Acetonide (TA) for the treatment of chronic ocular diseases. The photo cross-linked implants were prepared using film casting technique by mixing TA (2.5%) polyethylene glycol diacrylate (PEGDA 700), pore formers (mannitol, maltose, and gelatin) and the photoinitiator (Irgacure 2959). The resulting mixture was injected into moulds using 21 G and subjected to photocrosslinking at 365 nm. Scanning electron microscopy results demonstrated that more pores were formed in the films with the increase in the concentration of pore formers from 2%-10%. The maximum force required to break the films containing 2-10% of pore formers were determined in both dry and wet conditions using texture analyzer and found that films in a dry condition required a higher force to break compared to wet condition and blank films. In vitro drug release from photo cross-linked films were determined by incubating samples in 50 ml PBS pH 7.4 at 37 C and the samples were analyzed for drug release by HPLC. The films demonstrated a biphasic release profile i.e. an initial burst release (<20%) on the first day followed by a constant and continuous drug release in a controlled manner for 42 days. The drug release from all formulations followed the first-order release pattern and the combination of diffusion and erosion release mechanism. In conclusion, the developed formulations were able to provide controlled drug delivery to treat the chronic ocular diseases. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=controlled%20release" title="controlled release">controlled release</a>, <a href="https://publications.waset.org/abstracts/search?q=ophthalmic" title=" ophthalmic"> ophthalmic</a>, <a href="https://publications.waset.org/abstracts/search?q=PEGDA" title=" PEGDA"> PEGDA</a>, <a href="https://publications.waset.org/abstracts/search?q=photocrosslinking" title=" photocrosslinking"> photocrosslinking</a>, <a href="https://publications.waset.org/abstracts/search?q=pore%20formers" title=" pore formers"> pore formers</a> </p> <a href="https://publications.waset.org/abstracts/51380/development-and-characterization-of-controlled-release-photo-cross-linked-implants-for-ocular-delivery-of-triamcinolone-acetonide" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/51380.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">404</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3473</span> Formulation of Extended-Release Ranolazine Tablet and Investigation Its Stability in the Accelerated Stability Condition at 40⁰C and 75% Humidity</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Farzad%20Khajavi">Farzad Khajavi</a>, <a href="https://publications.waset.org/abstracts/search?q=Farzaneh%20Jalilfar"> Farzaneh Jalilfar</a>, <a href="https://publications.waset.org/abstracts/search?q=Faranak%20Jafari"> Faranak Jafari</a>, <a href="https://publications.waset.org/abstracts/search?q=Leila%20Shokrani"> Leila Shokrani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Formulation of Ranolazine in the form of extended-release tablet in 500 mg dosage form was performed using Eudragit L100-55 as a retarding agent. Drug-release profiles were investigated in comparison with the reference Ranexa extended-release 500 mg tablet. F₂ and f₁ were calculated as 64.16 and 8.53, respectively. According to Peppas equation, the release of drug is controlled by diffusion (n=0.5). The tablets were put into accelerated stability conditions (40 °C, 75% humidity) for 3 and 6 months. The dissolution release profiles and other physical and chemical characteristics of the tablets confirmed the robustness and stability of formulation in this condition. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=drug%20release" title="drug release">drug release</a>, <a href="https://publications.waset.org/abstracts/search?q=extended-release%20tablet" title=" extended-release tablet"> extended-release tablet</a>, <a href="https://publications.waset.org/abstracts/search?q=ranolazine" title=" ranolazine"> ranolazine</a>, <a href="https://publications.waset.org/abstracts/search?q=stability" title=" stability"> stability</a> </p> <a href="https://publications.waset.org/abstracts/127040/formulation-of-extended-release-ranolazine-tablet-and-investigation-its-stability-in-the-accelerated-stability-condition-at-40c-and-75-humidity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/127040.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">155</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3472</span> Slow and Controlled Release Fertilizer Technology via Application of Plant-available Inorganic Coatings</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Eugene%20Rybin">Eugene Rybin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Reduction of nutrient losses when using mineral fertilizers is a very important and urgent challenge, which is of both economic and environmental significance. This paper shows the production of slow- and controlled release fertilizers through application of inorganic coatings, which make the released nutrients plant-available. The method of production of coated fertilizers with inorganic cover material is an alternative to other methods where polymer coatings are used. The method is based on spraying an aqueous slurry onto the surface of granules with simultaneous drying in drums under certain conditions and subsequent cooling of granules. This method of production of slow- and controlled-release fertilizers is more ecofriendly compared with others because inorganic materials are used to create a membrane. That is why the coating material is definitely biodegradable. There is also shown the effect of these coatings on the properties of fertilizers, as well as on the agrochemical efficiency and nutrient efficiency/ availability to the plants. The agrochemical tests have proved the increase of nutrient efficiency for every nutrient in compound fertilizers (NPK, NPS) for 3 consecutive years by 10-20 % and by 25-28% for urea, as well as an increase in crop yield, by 10-15% in general, and its quality. Moreover, the decrease in caking by almost 70% was proven as well as slowing down the release rate of nutrients from fertilizers. Control of the release rate was achieved by regulation of thickness and contents of coating materials. All of those characteristics were researched according to the standard-used methods. The performed research has developed the fertilizer technology of slow- and controlled release of nutrients through applying of plant-available inorganic coatings. It leads to a better synchronization of nutrient release rate and plants needs, as well as reduces the harmful effects on the environment from the fertilizers applied. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=controlled%20release" title="controlled release">controlled release</a>, <a href="https://publications.waset.org/abstracts/search?q=fertilizers" title=" fertilizers"> fertilizers</a>, <a href="https://publications.waset.org/abstracts/search?q=nutrients" title=" nutrients"> nutrients</a>, <a href="https://publications.waset.org/abstracts/search?q=plant-available%20coatings" title=" plant-available coatings"> plant-available coatings</a> </p> <a href="https://publications.waset.org/abstracts/159617/slow-and-controlled-release-fertilizer-technology-via-application-of-plant-available-inorganic-coatings" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/159617.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">97</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3471</span> Synthesis Characterisation and Evaluation of Co-Processed Wax Matrix Excipient for Controlled Release Tablets Formulation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=M.%20Kalyan%20Raj">M. Kalyan Raj</a>, <a href="https://publications.waset.org/abstracts/search?q=Vinay%20Umesh%20Rao"> Vinay Umesh Rao</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20Sudhakar"> M. Sudhakar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The work focuses on the development of a directly compressible controlled release co-processed excipient using melt granulation technique. Erodible wax matrix systems are fabricated in which three different types of waxes are co processed separately with Maize starch in different ratios by melt granulation. The resultant free flowing powder is characterized by FTIR, NMR, Mass spectrophotometer and gel permeation chromatography. Also, controlled release tablets of Aripiprazole were formulated and dissolution profile was compared with that of the target product profile given in Zysis patent (Patent no. 20100004262) for Aripiprazole once a week formulation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=co-processing" title="co-processing">co-processing</a>, <a href="https://publications.waset.org/abstracts/search?q=hot%20melt%20extrusion" title=" hot melt extrusion"> hot melt extrusion</a>, <a href="https://publications.waset.org/abstracts/search?q=direct%20compression" title=" direct compression"> direct compression</a>, <a href="https://publications.waset.org/abstracts/search?q=maize%20starch" title=" maize starch"> maize starch</a>, <a href="https://publications.waset.org/abstracts/search?q=stearic%20acid" title=" stearic acid"> stearic acid</a>, <a href="https://publications.waset.org/abstracts/search?q=aripiprazole" title=" aripiprazole"> aripiprazole</a> </p> <a href="https://publications.waset.org/abstracts/8897/synthesis-characterisation-and-evaluation-of-co-processed-wax-matrix-excipient-for-controlled-release-tablets-formulation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/8897.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">408</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3470</span> Repellent Activity of Nanoemulsion Essential Oil of Eucalyptus Globulus Labill on Ephestia kuehniella (Lepidoptera: Pyralidae)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lena%20Emamjomeh">Lena Emamjomeh</a>, <a href="https://publications.waset.org/abstracts/search?q=Sohrab%20Imani"> Sohrab Imani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Nowadays, the use of encapsulation technology of pesticides causes an increase in the efficiency and controlled release of these substances. Controlled release by nanoencapsulated formulations allows the essential oil to be used more effectively over a given time interval, suitability to the mode of application and minimization of environmental damage. The essential oil from Eucalyptus globulus exhibited an average yield of 1.19% and presented 1,8-cineol (59.08%) as the major component. Nanoemulsion essential oil was carried out by the method of gum - maltodextrin using homogenization and morphology and size were determined by TEM. Several concentrations were prepared, and then third instar larvae of E.kuehniella were introduced into each treatment. Then, repellent activity was determined after 1, 3 and 24 h from commencement. This study reveals that at a concentration of 1.5 ppm, the nanoemulsion of E. globulus essential oil on the flour disc was shown here to possess more repellent activity (85%) than E.kuehniella compared to natural essential oil (5%) before formulation after 24h. The repellent activity varied with application method concentrations and exposure time. The results showed higher repellent rates in nanoemulsion than in essential oil due to controlled-release formulations allowing smaller quantities of essential oil to be used more effectively over a given time interval. Findings led to the conclusion that encapsulated technology of essential oils can enhance their control release and persistence under controlled conditions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nanoemulsion" title="nanoemulsion">nanoemulsion</a>, <a href="https://publications.waset.org/abstracts/search?q=eucalyptus%20globulus" title=" eucalyptus globulus"> eucalyptus globulus</a>, <a href="https://publications.waset.org/abstracts/search?q=ephestia%20kuehniella" title=" ephestia kuehniella"> ephestia kuehniella</a>, <a href="https://publications.waset.org/abstracts/search?q=TEM" title=" TEM"> TEM</a> </p> <a href="https://publications.waset.org/abstracts/186062/repellent-activity-of-nanoemulsion-essential-oil-of-eucalyptus-globulus-labill-on-ephestia-kuehniella-lepidoptera-pyralidae" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/186062.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">50</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3469</span> Preparation and Characterization of Poly (ε-caprolactone) Loaded with Layered Double Hydroxide Nanohybrid Intercalated with Alendronate for Osteoporosis Treatment</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Seyedeh%20Faranak%20Baniahmad">Seyedeh Faranak Baniahmad</a>, <a href="https://publications.waset.org/abstracts/search?q=Soroor%20Yousefi"> Soroor Yousefi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Osteoporosis is a bone disease which increases the bone fracture risk, reduces the bone mineral density (BMD) and alters the amount and variety of proteins in bones. Antiresorptive therapy is one the most popular Osteoporosis treatment methods. In this method the bisphosphonates, hormones, calcitonin or the selective estrogen receptor modulators is replaced. In order to reduce undesirable effects and to increase the bioavailability of drug agents, the controlled drug delivery systems have been utilized. In current study, the controlled release of Alendronate from LDH-PCL with (0, 5, 10, 15 % wt. of LDH) was investigated. The results showed that the release of alendronate from the lamellar LDH incorporated into the PCL matrix is much slower than the release of alendronate from the PCL. Therefore such systems are very promising, in which the antiresorptive drug has to remain in the matrix for longer time and can be released in controlled manner. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=osteoporosis" title="osteoporosis">osteoporosis</a>, <a href="https://publications.waset.org/abstracts/search?q=alendronate" title=" alendronate"> alendronate</a>, <a href="https://publications.waset.org/abstracts/search?q=poly%20%28%CE%B5%E2%80%93caprolactone%29" title=" poly (ε–caprolactone)"> poly (ε–caprolactone)</a>, <a href="https://publications.waset.org/abstracts/search?q=layered%20double%20hydroxide" title=" layered double hydroxide"> layered double hydroxide</a> </p> <a href="https://publications.waset.org/abstracts/1526/preparation-and-characterization-of-poly-e-caprolactone-loaded-with-layered-double-hydroxide-nanohybrid-intercalated-with-alendronate-for-osteoporosis-treatment" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/1526.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">394</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3468</span> Development of Nanostructrued Hydrogel for Spatial and Temporal Controlled Release of Active Compounds</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Shaker%20Alsharif">Shaker Alsharif</a>, <a href="https://publications.waset.org/abstracts/search?q=Xavier%20Banquy"> Xavier Banquy</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Controlled drug delivery technology represents one of the most rapidly advancing areas of science in which chemists and chemical engineers are contributing to human health care. Such delivery systems provide numerous advantages compared to conventional dosage forms including improved efficacy, and improved patient compliance and convenience. Such systems often use synthetic polymers as carriers for the drugs. As a result, treatments that would not otherwise be possible are now in conventional use. The role of bilayered vesicles as efficient carriers for drugs, vaccines, diagnostic agents and other bioactive agents have led to a rapid advancement in the liposomal drug delivery system. Moreover, the site avoidance and site-specific drug targeting therapy could be achieved by formulating a liposomal product, so as to reduce the cytotoxicity of many potent therapeutic agents. Our project focuses on developing and building hydrogel with nanoinclusion of liposomes loaded with active compounds such as proteins and growth factors able to release them in a controlled fashion. In order to achieve that, we synthesize several liposomes of two different phospholipids concentrations encapsulating model drug. Then, formulating hydrogel with specific mechanical properties embedding the liposomes to manage the release of active compound. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=controlled%20release" title="controlled release">controlled release</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrogel" title=" hydrogel"> hydrogel</a>, <a href="https://publications.waset.org/abstracts/search?q=liposomes" title=" liposomes"> liposomes</a>, <a href="https://publications.waset.org/abstracts/search?q=active%20compounds" title=" active compounds"> active compounds</a> </p> <a href="https://publications.waset.org/abstracts/33224/development-of-nanostructrued-hydrogel-for-spatial-and-temporal-controlled-release-of-active-compounds" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/33224.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">447</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3467</span> Sol-Gel Coated Fabric for Controlled Release of Mosquito Repellent</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bhaskar%20M.%20Murai">Bhaskar M. Murai</a>, <a href="https://publications.waset.org/abstracts/search?q=Neeraj%20Banchor"> Neeraj Banchor</a>, <a href="https://publications.waset.org/abstracts/search?q=Ishveen%20Chabbra"> Ishveen Chabbra</a>, <a href="https://publications.waset.org/abstracts/search?q=Madhusudhan%20Nadgir"> Madhusudhan Nadgir</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Vidhya"> S. Vidhya</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Sol-gel technology combined with electronics and biochemistry helps to overcome the problems caused by mosquitoes by developing a portable, low-cost device which enables controlled release of trapped compound inside it. It is a wet-chemical technique which is used primarily for fabrication of silicate gel which is usually allowed to dry as per requirement. The outcome is solid rock hard material which is porous and has lots of applications in different fields. Taking porosity as a key factor, allethrin a naturally occurring synthetic compound with molecular mass 302.40 was entrapped inside the sol-gel matrix as a dopant. Allethrin is commonly used as an insecticide and is a key ingredient in commercially available mosquitoes repellent in Asian and subtropical countries. It has low toxicity for humans and birds, and are used in many household insecticides such as RAID as well as mosquito coils. They are however highly toxic to fish and bees. Insects subject to its exposure become paralyzed (nervous system effect) before dying. They are also used as an ultra-low volume spray for outdoor mosquito control. Therefore, there is a need for controlled release of allethrin in the environment. For controlled release of allethrin from sol-gel matrix, its (allethrin) we utilized temperature based controlled evaporation through porous sol-gel. Different types of fabric like cotton, Terri-cotton, polyester, surgical cap, knee-cap etc are studied and the best with maximum absorption capacity is selected to hold the sol-gel matrix with maximum quantity. For sol-gel coating 2 x 2cm cloth pieces are dipped in sol-gel solution for 10 minutes and by calculating the weight difference we concluded that Terri cotton is best suitable for our project. An electronic circuit with heating plate is developed in to test the controlled release of compound. An oscillatory circuit is used to produce the required heat. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=sol-gel" title="sol-gel">sol-gel</a>, <a href="https://publications.waset.org/abstracts/search?q=allethrin" title=" allethrin"> allethrin</a>, <a href="https://publications.waset.org/abstracts/search?q=TEOS" title=" TEOS"> TEOS</a>, <a href="https://publications.waset.org/abstracts/search?q=biochemistry" title=" biochemistry"> biochemistry</a> </p> <a href="https://publications.waset.org/abstracts/21074/sol-gel-coated-fabric-for-controlled-release-of-mosquito-repellent" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/21074.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">375</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3466</span> Exploring the Application of Additive Manufacturing in the Production of Aerogels for the Purpose of Creating Environmentally Friendly Agricultural Formulations with Controlled Release Properties</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Pram%20Abhayawardhana">Pram Abhayawardhana</a>, <a href="https://publications.waset.org/abstracts/search?q=Ali%20Reza%20Nazmi"> Ali Reza Nazmi</a>, <a href="https://publications.waset.org/abstracts/search?q=Hossein%20Najaf%20Zadeh"> Hossein Najaf Zadeh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This study examines the use of additive manufacturing (AM) to develop sustainable and intelligent agricultural formulations that can gradually release fertilisers. AM offers the ability to design customised formulations with precise geometries and controlled release properties while taking into account their mechanical, chemical, and environmental properties. The study specifically investigates the use of an aerogel matrix mixed with a potential fertiliser in agriculture. Highly porous 3D printed aerogel structures were designed to enable the slow release of fertilisers. The performance of the formulated mixture is evaluated against other commonly used materials for slow-release applications. The findings suggest that the 3D printed gel made has great potential for slow-release fertilisers, providing an environmentally friendly solution for agricultural practices. The combination of AM technology and sustainable materials can play a vital role in mitigating the negative environmental impact of traditional fertilisers, as well as improving the efficiency and sustainability of agricultural production. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=3D%20printing" title="3D printing">3D printing</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrogel" title=" hydrogel"> hydrogel</a>, <a href="https://publications.waset.org/abstracts/search?q=aerogel" title=" aerogel"> aerogel</a>, <a href="https://publications.waset.org/abstracts/search?q=fertiliser" title=" fertiliser"> fertiliser</a>, <a href="https://publications.waset.org/abstracts/search?q=agriculture" title=" agriculture"> agriculture</a> </p> <a href="https://publications.waset.org/abstracts/163659/exploring-the-application-of-additive-manufacturing-in-the-production-of-aerogels-for-the-purpose-of-creating-environmentally-friendly-agricultural-formulations-with-controlled-release-properties" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/163659.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">94</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3465</span> Producing Fertilizers of Increased Environmental and Agrochemical Efficiency via Application of Plant-available Inorganic Coatings</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Andrey%20Norov">Andrey Norov</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Reduction of inefficient losses of nutrients when using mineral fertilizers is a very important and urgent challenge, which is of both economic and environmental significance. The loss of nutrients to the environment leads to the release of greenhouse gases, eutrophication of water bodies, soil salinization and degradation, and other undesirable phenomena. This report focuses on slow and controlled release fertilizers produced through the application of inorganic coatings, which make the released nutrients plant-available. There are shown the advantages of these fertilizers their improved physical and chemical properties, as well as the effect of the coatings on yield growth and on the degree of nutrient efficiency. This type of fertilizers is an alternative to other polymer-coated fertilizers and is more ecofriendly. The production method is protected by the Russian patent. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=coatings" title="coatings">coatings</a>, <a href="https://publications.waset.org/abstracts/search?q=controlled%20release" title=" controlled release"> controlled release</a>, <a href="https://publications.waset.org/abstracts/search?q=fertilizer" title=" fertilizer"> fertilizer</a>, <a href="https://publications.waset.org/abstracts/search?q=nutrients" title=" nutrients"> nutrients</a>, <a href="https://publications.waset.org/abstracts/search?q=nutrient%20efficiency" title=" nutrient efficiency"> nutrient efficiency</a>, <a href="https://publications.waset.org/abstracts/search?q=yield%20increase" title=" yield increase"> yield increase</a> </p> <a href="https://publications.waset.org/abstracts/159620/producing-fertilizers-of-increased-environmental-and-agrochemical-efficiency-via-application-of-plant-available-inorganic-coatings" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/159620.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">95</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3464</span> Ultrasound Enhanced Release of Active Targeting Liposomes Used for Cancer Treatment</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Najla%20M.%20Salkho">Najla M. Salkho</a>, <a href="https://publications.waset.org/abstracts/search?q=Vinod%20Paul"> Vinod Paul</a>, <a href="https://publications.waset.org/abstracts/search?q=Pierre%20Kawak"> Pierre Kawak</a>, <a href="https://publications.waset.org/abstracts/search?q=Rute%20F.%20Vitor"> Rute F. Vitor</a>, <a href="https://publications.waset.org/abstracts/search?q=Ana%20M.%20Martin"> Ana M. Martin</a>, <a href="https://publications.waset.org/abstracts/search?q=Nahid%20Awad"> Nahid Awad</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammad%20Al%20Sayah"> Mohammad Al Sayah</a>, <a href="https://publications.waset.org/abstracts/search?q=Ghaleb%20A.%20Husseini"> Ghaleb A. Husseini</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Liposomes are popular lipid bilayer nanoparticles that are highly efficient in encapsulating both hydrophilic and hydrophobic therapeutic drugs. Liposomes promote a low risk controlled release of the drug avoiding the side effects of the conventional chemotherapy. One of the great potentials of liposomes is the ability to attach a wide range of ligands to their surface producing ligand-mediated active targeting of cancer tumour with limited adverse off-target effects. Ultrasound can also aid in the controlled and specified release of the drug from the liposomes by breaking it apart and releasing the drug in the specific location where the ultrasound is applied. Our research focuses on the synthesis of PEGylated liposomes (contain poly-ethylene glycol) encapsulated with the model drug calcein and studying the effect of low frequency ultrasound applied at different power densities on calcein release. In addition, moieties are attached to the surface of the liposomes for specific targeting of the cancerous cells which over-express the receptors of these moieties, ultrasound is then applied and the release results are compared with the moiety free liposomes. The results showed that attaching these moieties to the surface of the PEGylated liposomes not only enhance their active targeting but also stimulate calcein release from these liposomes. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=active%20targeting" title="active targeting">active targeting</a>, <a href="https://publications.waset.org/abstracts/search?q=liposomes" title=" liposomes"> liposomes</a>, <a href="https://publications.waset.org/abstracts/search?q=moieties" title=" moieties"> moieties</a>, <a href="https://publications.waset.org/abstracts/search?q=ultrasound" title=" ultrasound"> ultrasound</a> </p> <a href="https://publications.waset.org/abstracts/78619/ultrasound-enhanced-release-of-active-targeting-liposomes-used-for-cancer-treatment" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/78619.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">602</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3463</span> Nitrogen, Phosphorus, Potassium (NPK) Hydroxyapatite Nano-Hybrid Slow Release Fertilizer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Tinomuvonga%20Manenji%20Zhou">Tinomuvonga Manenji Zhou</a>, <a href="https://publications.waset.org/abstracts/search?q=Eubert%20Mahofa"> Eubert Mahofa</a>, <a href="https://publications.waset.org/abstracts/search?q=Tatenda%20Crispen%20Madzokere"> Tatenda Crispen Madzokere</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The nanostructured formulation can increase fertilizer efficacy and uptake ratio of the soil nutrients in agriculture production and save fertilizer resources. Controlled release modes have properties of both release rate and release pattern of nutrients, for fertilizers that are soluble in water might be correctly controlled. Nanoparticles can reduce the rate at which fertilizer nutrients are in the soil by leaching. A slow release NPK-hydroxyapatite nano hybrid fertilizer was synthesized using exfoliated bentonite as filler material. A simple, scalable method was used to synthesize the nitrogen-phosphorus hydroxyapatite nano fertilizer, where calcium hydroxide, phosphoric acid, and urea were used as precursor material, followed by the incorporation of potassium through a liquid grinding method. The product obtained was an NPK-hydroxyapatite nano hybrid fertilizer. A quantitative analysis was done to determine the percentage of nitrogen, phosphorus, and potassium in the hybrid fertilizer. AAS was used to determine the percentage of potassium in the fertilizer. An accelerated water test was conducted to compare the nutrient release behavior of nutrients between the synthesized NPK-hydroxyapatite nano hybrid fertilizer and commercial NPK fertilizer. The rate of release of Nitrogen, phosphorus, and potassium was significantly lower in the synthesized NPK hydroxyapatite nano hybrid fertilizer than in the convectional NPK fertilizer. The synthesized fertilizer was characterized using XRD. NPK hydroxyapatite nano hybrid fertilizer encapsulated in exfoliated bentonite thus prepared can be used as an environmentally friendly fertilizer formulation which could be extended to solve one of the major problems faced in the global fertilization of low nitrogen, phosphorus, and potassium use efficiency in agriculture. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=NPK%20hydroxyapatite%20nano%20hybrid%20fertilizer" title="NPK hydroxyapatite nano hybrid fertilizer">NPK hydroxyapatite nano hybrid fertilizer</a>, <a href="https://publications.waset.org/abstracts/search?q=bentonite" title=" bentonite"> bentonite</a>, <a href="https://publications.waset.org/abstracts/search?q=encapsulation" title=" encapsulation"> encapsulation</a>, <a href="https://publications.waset.org/abstracts/search?q=low%20release" title=" low release"> low release</a> </p> <a href="https://publications.waset.org/abstracts/163701/nitrogen-phosphorus-potassium-npk-hydroxyapatite-nano-hybrid-slow-release-fertilizer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/163701.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">94</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3462</span> Upconversion Nanoparticles for Imaging and Controlled Photothermal Release of Anticancer Drug in Breast Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rishav%20Shrestha">Rishav Shrestha</a>, <a href="https://publications.waset.org/abstracts/search?q=Yong%20Zhang"> Yong Zhang</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The Anti-Stoke upconversion process has been used extensively for bioimaging and is recently being used for photoactivated therapy in cancer utilizing upconversion nanoparticles (UCNs). The UCNs have an excitation band at 980nm; 980nm laser excitation used to produce UV/Visible emissions also produce a heating effect. Light-to-heat conversion has been observed in nanoparticles(NPs) doped with neodymium(Nd) or ytterbium(Yb)/erbium(Er) ions. Despite laser-induced heating in Rare-earth doped NPs being proven to be a relatively efficient process, only few attempts to use them as photothermal agents in biosystems have been made up to now. Gold nanoparticles and carbon nanotubes are the most researched and developed for photothermal applications. Both have large heating efficiency and outstanding biocompatibility. However, they show weak fluorescence which makes them harder to track in vivo. In that regard, UCNs are attractive due to their excellent optical features in addition to their light-to-heat conversion and excitation by NIR, for imaging and spatiotemporally releasing drugs. In this work, we have utilized a simple method to coat Nd doped UCNs with thermoresponsive polymer PNIPAM on which 4-Hydroxytamoxifen (4-OH-T) is loaded. Such UCNs demonstrate a high loading efficiency and low leakage of 4-OH-T. Encouragingly, the release of 4-OH-T can be modulated by varying the power and duration of the NIR. Such UCNs were then used to demonstrate imaging and controlled photothermal release of 4-OH-T in MCF-7 breast cancer cells. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cancer%20therapy" title="cancer therapy">cancer therapy</a>, <a href="https://publications.waset.org/abstracts/search?q=controlled%20release" title=" controlled release"> controlled release</a>, <a href="https://publications.waset.org/abstracts/search?q=photothermal%20release" title=" photothermal release"> photothermal release</a>, <a href="https://publications.waset.org/abstracts/search?q=upconversion%20nanoparticles" title=" upconversion nanoparticles"> upconversion nanoparticles</a> </p> <a href="https://publications.waset.org/abstracts/24020/upconversion-nanoparticles-for-imaging-and-controlled-photothermal-release-of-anticancer-drug-in-breast-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/24020.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">422</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3461</span> Production of a Sustainable Slow-Release Urea Fertilizer Using Starch and Poly-Vinyl Alcohol</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=A.%20M.%20H.%20Shokry">A. M. H. Shokry</a>, <a href="https://publications.waset.org/abstracts/search?q=N.%20S.%20M.%20El-Tayeb"> N. S. M. El-Tayeb</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The environmental impacts caused by fertilizers call for the adaptation of more sustainable technologies in order to increase agricultural production and reduce pollution due to high nutrient emissions. One particular technique has been to coat urea fertilizer granules with less-soluble chemicals that permit the gradual release of nutrients in a slow and controlled manner. The aim of this research is to develop a biodegradable slow-release fertilizer (SRF) with materials that come from sustainable sources; starch and polyvinyl alcohol (PVA). The slow-release behavior and water retention capacity of the coated granules were determined. In addition, the aqueous release and absorbency rates were also tested. Results confirmed that the release rate from coated granules was slower than through plain membranes; and that the water absorption capacity of the coated urea decreased as PVA content increased. The SRF was also tested and gave positive results that confirmed the integrity of the product. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=biodegradability" title="biodegradability">biodegradability</a>, <a href="https://publications.waset.org/abstracts/search?q=nitrogen-use%20efficiency" title=" nitrogen-use efficiency"> nitrogen-use efficiency</a>, <a href="https://publications.waset.org/abstracts/search?q=poly-vinyl%20alcohol" title=" poly-vinyl alcohol"> poly-vinyl alcohol</a>, <a href="https://publications.waset.org/abstracts/search?q=slow-release%20fertilizer" title=" slow-release fertilizer"> slow-release fertilizer</a>, <a href="https://publications.waset.org/abstracts/search?q=sustainability" title=" sustainability"> sustainability</a> </p> <a href="https://publications.waset.org/abstracts/139377/production-of-a-sustainable-slow-release-urea-fertilizer-using-starch-and-poly-vinyl-alcohol" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/139377.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">214</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3460</span> Green Approach towards Synthesis of Chitosan Nanoparticles for in vitro Release of Quercetin</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Dipali%20Nagaonkar">Dipali Nagaonkar</a>, <a href="https://publications.waset.org/abstracts/search?q=Mahendra%20Rai"> Mahendra Rai </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Chitosan, a carbohydrate polymer at nanoscale level has gained considerable momentum in drug delivery applications due to its inherent biocompatibility and non-toxicity. However, conventional synthetic strategies for chitosan nanoparticles mainly rely upon physicochemical techniques, which often yield chitosan microparticles. Hence, there is an emergent need for development of controlled synthetic protocols for chitosan nanoparticles within the nanometer range. In this context, we report the green synthesis of size controlled chitosan nanoparticles by using Pongamia pinnata (L.) leaf extract. Nanoparticle tracking analysis confirmed formation of nanoparticles with mean particle size of 85 nm. The stability of chitosan nanoparticles was investigated by zetasizer analysis, which revealed positive surface charged nanoparticles with zeta potential 20.1 mV. The green synthesized chitosan nanoparticles were further explored for encapsulation and controlled release of antioxidant biomolecule, quercetin. The resulting drug loaded chitosan nanoparticles showed drug entrapment efficiency of 93.50% with drug-loading capacity of 42.44%. The cumulative in vitro drug release up to 15 hrs was achieved suggesting towards efficacy of green synthesized chitosan nanoparticles for drug delivery applications. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Chitosan%20nanoparticles" title="Chitosan nanoparticles">Chitosan nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=green%20synthesis" title=" green synthesis"> green synthesis</a>, <a href="https://publications.waset.org/abstracts/search?q=Pongamia%20pinnata" title=" Pongamia pinnata"> Pongamia pinnata</a>, <a href="https://publications.waset.org/abstracts/search?q=quercetin" title=" quercetin"> quercetin</a> </p> <a href="https://publications.waset.org/abstracts/20293/green-approach-towards-synthesis-of-chitosan-nanoparticles-for-in-vitro-release-of-quercetin" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/20293.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">576</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3459</span> Pharmacokinetics of Oral Controlled-Release Formulation of Doxycycline Hyclate with Polymethacrylate and Acrylic Acid for Dogs</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=S.%20M.%20Arciniegas">S. M. Arciniegas</a>, <a href="https://publications.waset.org/abstracts/search?q=D.%20Vargas"> D. Vargas</a>, <a href="https://publications.waset.org/abstracts/search?q=L.%20Gutierrez"> L. Gutierrez</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The aim of this study was to develop oral drug presentation of doxycycline hyclate that maintains longer therapeutic levels than conventional forms. A polymethacrylate and acrylic acid based matrix were used in different proportions to obtain controlled-release formulations; DOX1 (1:0.25:0.0035), DOX2 (1:2:0.0225) and DOX-C (without excipients). All were tested in vivo in healthy dogs and their serum concentrations vs. time profile was investigated after its oral administration in this species. DOX1 and DOX2 show therapeutic concentrations for 60 hours, while DOX-C only for 24 hours. The pharmacokinetics values tested were K½el, Cmax, Tmax, AUC, AUC∞, AUCt, AUMC, RT, Kel, Vdss, Clb and Frel. DOX1 does not differ significantly from DOX-C, but shows significant differences in all variables with DOX2 (p<0.05). In conclusion, DOX1 presents best pharmacokinetics for time-dependent drug and longer release time of 60 hours, thereby reducing the frequency of administration, the patient's stress, the occurrence of adverse effects and the cost of treatment. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=tetracyclines" title="tetracyclines">tetracyclines</a>, <a href="https://publications.waset.org/abstracts/search?q=long-acting" title=" long-acting"> long-acting</a>, <a href="https://publications.waset.org/abstracts/search?q=sustained-release" title=" sustained-release"> sustained-release</a>, <a href="https://publications.waset.org/abstracts/search?q=carbopol" title=" carbopol"> carbopol</a>, <a href="https://publications.waset.org/abstracts/search?q=eudragit" title=" eudragit"> eudragit</a>, <a href="https://publications.waset.org/abstracts/search?q=canine" title=" canine"> canine</a> </p> <a href="https://publications.waset.org/abstracts/7169/pharmacokinetics-of-oral-controlled-release-formulation-of-doxycycline-hyclate-with-polymethacrylate-and-acrylic-acid-for-dogs" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/7169.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">613</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3458</span> Polymer Composites Of MOF-5 For Efficient and Sustained Delivery of Cephalexin and Metronidazole</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Anoff%20Anim">Anoff Anim</a>, <a href="https://publications.waset.org/abstracts/search?q=Lila%20Mahmoud"> Lila Mahmoud</a>, <a href="https://publications.waset.org/abstracts/search?q=Maria%20Katsikogianni"> Maria Katsikogianni</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanjit%20Nayak"> Sanjit Nayak</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Sustained and controlled delivery of antimicrobial drugs have been largely studied recently using metal organic frameworks (MOFs)and different polymers. However, much attention has not been given to combining both MOFs and biodegradable polymers, which would be a good strategy in providing a sustained gradual release of the drugs. Herein, we report a comparative study of the sustained and controlled release of widely used antibacterial drugs, cephalexin and metronidazole, from zinc-based MOF-5 incorporated in biodegradable polycaprolactone (PCL) and poly-lactic glycolic acid (PLGA) membranes. Cephalexin and metronidazole were separately incorporated in MOF-5 post-synthetically, followed by their integration into biodegradable PLGA and PCL membranes. The pristine MOF-5 and the loaded MOFs were thoroughly characterized by FT-IR, SEM, TGA and PXRD. Drug release studies were carried out to assess the release rate of the drugs in PBS and distilled water for up to 48 hours using UV-Vis Spectroscopy. Four bacterial strains from both the Gram-positive and Gram-negative types, Staphylococus aureus, Staphylococuss epidermidis, Escherichia coli, Acinetobacter baumanii, were tested against the pristine MOF, pure drugs, loaded MOFs and the drug-loaded MOF-polymer composites. Metronidazole-loaded MOF-5 composite of PLGA (PLGA-Met@MOF-5) was found to show highest efficiency to inhibit the growth of S. epidermidis compared to the other bacteria strains while maintaining a sustained minimum inhibitory concentration (MIC). This study demonstrates that the combination of biodegradable MOF-polymer composites can provide an efficient platform for sustained and controlled release of antimicrobial drugs and can be a potential strategy to integrate them in biomedical devices. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antimicrobial%20resistance" title="antimicrobial resistance">antimicrobial resistance</a>, <a href="https://publications.waset.org/abstracts/search?q=biodegradable%20polymers" title=" biodegradable polymers"> biodegradable polymers</a>, <a href="https://publications.waset.org/abstracts/search?q=cephalexin" title=" cephalexin"> cephalexin</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20release%20metronidazole" title=" drug release metronidazole"> drug release metronidazole</a>, <a href="https://publications.waset.org/abstracts/search?q=MOF-5" title=" MOF-5"> MOF-5</a>, <a href="https://publications.waset.org/abstracts/search?q=PCL" title=" PCL"> PCL</a>, <a href="https://publications.waset.org/abstracts/search?q=PLGA" title=" PLGA"> PLGA</a> </p> <a href="https://publications.waset.org/abstracts/170701/polymer-composites-of-mof-5-for-efficient-and-sustained-delivery-of-cephalexin-and-metronidazole" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/170701.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">133</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3457</span> Biodegradable Polymer Composites of MOF-5 for Efficient and Sustained Delivery of Cephalexin and Metronidazole</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Anoff%20Anim">Anoff Anim</a>, <a href="https://publications.waset.org/abstracts/search?q=Lila%20A.%20M.%20Mahmoud"> Lila A. M. Mahmoud</a>, <a href="https://publications.waset.org/abstracts/search?q=Maria%20Katsikogianni"> Maria Katsikogianni</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanjit%20Nayak"> Sanjit Nayak</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Sustained and controlled delivery of antimicrobial drugs have been largely studied recently using metal organic frameworks (MOFs)and different polymers. However, much attention has not been given to combining both MOFs and biodegradable polymers, which would be a good strategy in providing a sustained gradual release of the drugs. Herein, we report a comparative study of the sustained and controlled release of widely used antibacterial drugs, cephalexin and metronidazole, from zinc-based MOF-5 incorporated in biodegradable polycaprolactone (PCL) and poly-lactic glycolic acid (PLGA) membranes. Cephalexin and metronidazole were separately incorporated in MOF-5 post-synthetically, followed by their integration into biodegradable PLGA and PCL membranes. The pristine MOF-5 and the loaded MOFs were thoroughly characterized by FT-IR, SEM, TGA and PXRD. Drug release studies were carried out to assess the release rate of the drugs in PBS and distilled water for up to 48 hours using UV-Vis Spectroscopy. Four bacterial strains from both the Gram-positive and Gram-negative types, Staphylococus aureus, Staphylococuss epidermidis, Escherichia coli, Acinetobacter baumanii, were tested against the pristine MOF, pure drugs, loaded MOFs and the drug-loaded MOF-polymer composites. Metronidazole-loaded MOF-5 composite of PLGA (PLGA-Met@MOF-5) was found to show highest efficiency to inhibit the growth of S. epidermidis compared to the other bacteria strains while maintaining a sustained minimum inhibitory concentration (MIC). This study demonstrates that the combination of biodegradable MOF-polymer composites can provide an efficient platform for sustained and controlled release of antimicrobial drugs and can be a potential strategy to integrate them in biomedical devices. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antimicrobial%20resistance" title="antimicrobial resistance">antimicrobial resistance</a>, <a href="https://publications.waset.org/abstracts/search?q=biodegradable%20polymers" title=" biodegradable polymers"> biodegradable polymers</a>, <a href="https://publications.waset.org/abstracts/search?q=cephalexin" title=" cephalexin"> cephalexin</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20release%20metronidazole" title=" drug release metronidazole"> drug release metronidazole</a>, <a href="https://publications.waset.org/abstracts/search?q=MOF-5" title=" MOF-5"> MOF-5</a>, <a href="https://publications.waset.org/abstracts/search?q=PCL" title=" PCL"> PCL</a>, <a href="https://publications.waset.org/abstracts/search?q=PLGA" title=" PLGA"> PLGA</a> </p> <a href="https://publications.waset.org/abstracts/170686/biodegradable-polymer-composites-of-mof-5-for-efficient-and-sustained-delivery-of-cephalexin-and-metronidazole" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/170686.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">139</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3456</span> Reducing Antimicrobial Resistance Using Biodegradable Polymer Composites of Mof-5 for Efficient and Sustained Delivery of Cephalexin and Metronidazole</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Anoff%20Anim">Anoff Anim</a>, <a href="https://publications.waset.org/abstracts/search?q=Lila%20Mahmound"> Lila Mahmound</a>, <a href="https://publications.waset.org/abstracts/search?q=Maria%20Katsikogianni"> Maria Katsikogianni</a>, <a href="https://publications.waset.org/abstracts/search?q=Sanjit%20Nayak"> Sanjit Nayak</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Sustained and controlled delivery of antimicrobial drugs have been largely studied recently using metal organic frameworks (MOFs)and different polymers. However, much attention has not been given to combining both MOFs and biodegradable polymers which would be a good strategy in providing a sustained gradual release of the drugs. Herein, we report a comparative study of the sustained and controlled release of widely used antibacterial drugs, cephalexin and metronidazole, from zinc-based MOF-5 incorporated in biodegradable polycaprolactone (PCL) and poly-lactic glycolic acid (PLGA) membranes. Cephalexin and metronidazole were separately incorporated in MOF-5 post-synthetically, followed by their integration into biodegradable PLGA and PCL membranes. The pristine MOF-5 and the loaded MOFs were thoroughly characterized by FT-IR, SEM, TGA and PXRD. Drug release studies were carried out to assess the release rate of the drugs in PBS and distilled water for up to 48 hours using UV-Vis Spectroscopy. Four bacterial strains from both the Gram-positive and Gram-negative types, Staphylococus aureus, Staphylococuss epidermidis, Escherichia coli, Acinetobacter baumanii, were tested against the pristine MOF, pure drugs, loaded MOFs and the drug-loaded MOF-polymer composites. Metronidazole-loaded MOF-5 composite of PLGA (PLGA-Met@MOF-5) was found to show highest efficiency to inhibit the growth of S. epidermidis compared to the other bacteria strains while maintaining a sustained minimum inhibitory concentration (MIC). This study demonstrates that the combination of biodegradable MOF-polymer composites can provide an efficient platform for sustained and controlled release of antimicrobial drugs, and can be a potential strategy to integrate them in biomedical devices. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antimicrobial%20resistance" title="antimicrobial resistance">antimicrobial resistance</a>, <a href="https://publications.waset.org/abstracts/search?q=biodegradable%20polymers" title=" biodegradable polymers"> biodegradable polymers</a>, <a href="https://publications.waset.org/abstracts/search?q=cephalexin" title=" cephalexin"> cephalexin</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20release%20metronidazole" title=" drug release metronidazole"> drug release metronidazole</a>, <a href="https://publications.waset.org/abstracts/search?q=MOF-5" title=" MOF-5"> MOF-5</a>, <a href="https://publications.waset.org/abstracts/search?q=PCL" title=" PCL"> PCL</a>, <a href="https://publications.waset.org/abstracts/search?q=PLGA" title=" PLGA"> PLGA</a> </p> <a href="https://publications.waset.org/abstracts/170695/reducing-antimicrobial-resistance-using-biodegradable-polymer-composites-of-mof-5-for-efficient-and-sustained-delivery-of-cephalexin-and-metronidazole" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/170695.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">85</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3455</span> Development of pH Responsive Nanoparticles for Colon Targeted Drug Delivery System</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=V.%20Balamuralidhara">V. Balamuralidhara</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The aim of the present work was to develop Paclitaxel loaded polyacrylamide grafted guar gum nanoparticles as pH responsive nanoparticle systems for targeting colon. The pH sensitive nanoparticles were prepared by modified ionotropic gelation technique. The prepared nanoparticles showed mean diameters in the range of 264±0.676 nm to 726±0.671nm, and a negative net charge 10.8 mV to 35.4mV. Fourier Transformed Infrared Spectroscopy (FT-IR) and Differential Scanning Calorimetry (DSC) studies suggested that there was no chemical interaction between drug and polymers. The encapsulation efficiency of the drug was found to be 40.92% to 48.14%. The suitability of the polyacrylamide grafted guar gum ERN’s for the release of Paclitaxel was studied by in vitro release at pH 1.2 and 7.4. It was observed that, there was no significant amount of drug release at gastric pH and 97.63% of drug release at pH 7.4 was obtained for optimized formulation F3 at the end of 12 hrs. In vivo drug targeting performance for the prepared optimized formulation (F3) and pure drug Paclitaxel was evaluated by HPLC. It was observed that the polyacrylamide grafted guar gum can be used to prepare nanoparticles for targeting the drug to the colon. The release performance was greatly affected by the materials used in ERN’s preparation, which allows maximum release at colon’s pH. It may be concluded that polyacrylamide grafted guar gum nanoparticles loaded with paclitaxel have desirable release responsive to specific pH. Hence it is a unique approach for colonic delivery of drug having appropriate site specificity and feasibility and controlled release of drug. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=colon%20targeting" title="colon targeting">colon targeting</a>, <a href="https://publications.waset.org/abstracts/search?q=polyacrylamide%20grafted%20guar%20gum%20nanoparticles" title=" polyacrylamide grafted guar gum nanoparticles"> polyacrylamide grafted guar gum nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=paclitaxel" title=" paclitaxel"> paclitaxel</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoparticles" title=" nanoparticles"> nanoparticles</a> </p> <a href="https://publications.waset.org/abstracts/8472/development-of-ph-responsive-nanoparticles-for-colon-targeted-drug-delivery-system" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/8472.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">354</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3454</span> Poly(N-Vinylcaprolactam-Co-Itaconic Acid-Co-Ethylene Glycol Dimethacrylate)-Based Microgels Embedded in Chitosan Matrix for Controlled Release of Ketoprofen</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Simone%20F.%20Medeiros">Simone F. Medeiros</a>, <a href="https://publications.waset.org/abstracts/search?q=Jessica%20M.%20Fonseca"> Jessica M. Fonseca</a>, <a href="https://publications.waset.org/abstracts/search?q=Gizelda%20M.%20Alves"> Gizelda M. Alves</a>, <a href="https://publications.waset.org/abstracts/search?q=Danilo%20M.%20Santos"> Danilo M. Santos</a>, <a href="https://publications.waset.org/abstracts/search?q=S%C3%A9rgio%20P.%20Campana-Filho"> Sérgio P. Campana-Filho</a>, <a href="https://publications.waset.org/abstracts/search?q=Amilton%20M.%20Santos"> Amilton M. Santos</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Stimuli responsive and biocompatible hydrogel nanoparticles have gained special attention as systems for potential applications in controlled release of drugs to improve their therapeutic efficacy while minimizing side effects. In this work, novel solid dispersions based on thermo- and pH-responsive poly(N-vinylcaprolactam-co-itaconic acid-co-ethylene- glycol dimethacrylate) hydrogel nanoparticles embedded in chitosan matrices were prepared via spray drying for controlled release of ketoprofen. Firstly, the hydrogel nanoparticles containing ketoprofen were prepared via precipitation polymerization and their stimuli-responsive behavior, thermal properties, chemical composition, encapsulation efficiency and morphology were characterized. Then, hydrogel nanoparticles with different particles size were embedded into chitosan matrices via spray-drying. Scanning electron microscopy (SEM) analyses were performed to investigate the particles size, dispersity and morphology. Finally, ketoprofen release profiles were studied as a function of pH and temperature. Chitosan/poly(NVCL-co-IA-co-EGDMA)-ketoprofen microparticles presented spherical shape, rough surface and pronounced agglomeration, indicating that hydrogels nanoparticles loaded with ketoprofen modified the surface of chitosan matrix. The maximum encapsulation efficiency of ketoprofen into hydrogel nanoparticles was 57.8% and the electrostatic interactions between amino groups from chitosan and carboxylic groups from hydrogel nanoparticles were able to control ketoprofen release. The hydrogel nanoparticles themselves were capable to retard the release of ketoprofen-loaded until 48h of in vitro release tests, while their incorporation into chitosan matrix achieved a maximum percentage of drug release of 45%, using a mass ratio of chitosan: poly(NVCL-co-IA-co-EGDMA equal to 10:7, and 69%, using a mass ratio of chitosan: poly(NVCL-co-IA-co-EGDMA equal to 5:2. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=hydrogel%20nanoparticles" title="hydrogel nanoparticles">hydrogel nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=poly%28N-vinylcaprolactam-co-itaconic%20acid-co-ethylene-%20glycol%20dimethacrylate%29" title=" poly(N-vinylcaprolactam-co-itaconic acid-co-ethylene- glycol dimethacrylate)"> poly(N-vinylcaprolactam-co-itaconic acid-co-ethylene- glycol dimethacrylate)</a>, <a href="https://publications.waset.org/abstracts/search?q=chitosan" title=" chitosan"> chitosan</a>, <a href="https://publications.waset.org/abstracts/search?q=ketoprofen" title=" ketoprofen"> ketoprofen</a>, <a href="https://publications.waset.org/abstracts/search?q=spray-drying" title=" spray-drying"> spray-drying</a> </p> <a href="https://publications.waset.org/abstracts/81767/polyn-vinylcaprolactam-co-itaconic-acid-co-ethylene-glycol-dimethacrylate-based-microgels-embedded-in-chitosan-matrix-for-controlled-release-of-ketoprofen" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/81767.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">264</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3453</span> pH and Temperature Triggered Release of Doxorubicin from Hydogen Bonded Multilayer Films of Polyoxazolines</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Meltem%20Haktaniyan">Meltem Haktaniyan</a>, <a href="https://publications.waset.org/abstracts/search?q=Eda%20Cagli"> Eda Cagli</a>, <a href="https://publications.waset.org/abstracts/search?q=Irem%20Erel%20Goktepe"> Irem Erel Goktepe</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Polymers that change their properties in response to different stimuli (e.g. light, temperature, pH, ionic strength or magnetic field) are called ‘smart’ or ‘stimuli-responsive polymers’. These polymers have been widely used in biomedical applications such as sensors, gene delivery, drug delivery or tissue engineering. Temperature-responsive polymers have been studied extensively for controlled drug delivery applications. As regard of pseudo-peptides, poly (2-alky-2-oxazoline)s are considered as good candidates for delivery systems due to their stealth behavior and nontoxicity. In order to build responsive multilayer films for controlled drug release applications from surface, Layer by layer technique (LBL) is a powerful technique with an advantage of nanometer scale control over spatial architecture and morphology. Multilayers can be constructed on surface where non-covalent interactions including electrostatic interactions, hydrogen bonding, and charge-transfer or hydrophobic-hydrophobic interactions. In the present study, hydrogen bounded multilayer films of poly (2-alky-2-oxazoline) s with tannic acid were prepared in order to use as a platform to release Doxorubicin (DOX) from surface with pH and thermal triggers. For this purpose, poly (2-isopropyl-2-oxazoline) (PIPOX) and poly (2-ethyl-2-oxazoline) (PETOX) were synthesized via cationic ring opening polymerization (CROP) with hydroxyl end groups. Two polymeric multilayer systems ((PETOX)/(DOX)-(TA) complexes and (PIPOX)/(DOX)-(TA) complexes) were designed to investigate of controlled release of Doxorubicin (DOX) from surface with pH and thermal triggers. The drug release profiles from the multilayer thin films with alterations of pH and temperature will been examined with UV-Vis Spectroscopy and Fluorescence Spectroscopy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=temperature%20responsive%20polymers" title="temperature responsive polymers">temperature responsive polymers</a>, <a href="https://publications.waset.org/abstracts/search?q=h-bonded%20multilayer%20films" title=" h-bonded multilayer films"> h-bonded multilayer films</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20release" title=" drug release"> drug release</a>, <a href="https://publications.waset.org/abstracts/search?q=polyoxazoline" title=" polyoxazoline"> polyoxazoline</a> </p> <a href="https://publications.waset.org/abstracts/44688/ph-and-temperature-triggered-release-of-doxorubicin-from-hydogen-bonded-multilayer-films-of-polyoxazolines" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/44688.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">308</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3452</span> Response Surface Methodology to Obtain Disopyramide Phosphate Loaded Controlled Release Ethyl Cellulose Microspheres</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Krutika%20K.%20Sawant">Krutika K. Sawant</a>, <a href="https://publications.waset.org/abstracts/search?q=Anil%20Solanki"> Anil Solanki </a> </p> <p class="card-text"><strong>Abstract:</strong></p> The present study deals with the preparation and optimization of ethyl cellulose-containing disopyramide phosphate loaded microspheres using solvent evaporation technique. A central composite design consisting of a two-level full factorial design superimposed on a star design was employed for optimizing the preparation microspheres. The drug:polymer ratio (X1) and speed of the stirrer (X2) were chosen as the independent variables. The cumulative release of the drug at a different time (2, 6, 10, 14, and 18 hr) was selected as the dependent variable. An optimum polynomial equation was generated for the prediction of the response variable at time 10 hr. Based on the results of multiple linear regression analysis and F statistics, it was concluded that sustained action can be obtained when X1 and X2 are kept at high levels. The X1X2 interaction was found to be statistically significant. The drug release pattern fitted the Higuchi model well. The data of a selected batch were subjected to an optimization study using Box-Behnken design, and an optimal formulation was fabricated. Good agreement was observed between the predicted and the observed dissolution profiles of the optimal formulation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=disopyramide%20phosphate" title="disopyramide phosphate">disopyramide phosphate</a>, <a href="https://publications.waset.org/abstracts/search?q=ethyl%20cellulose" title=" ethyl cellulose"> ethyl cellulose</a>, <a href="https://publications.waset.org/abstracts/search?q=microspheres" title=" microspheres"> microspheres</a>, <a href="https://publications.waset.org/abstracts/search?q=controlled%20release" title=" controlled release"> controlled release</a>, <a href="https://publications.waset.org/abstracts/search?q=Box-Behnken%20design" title=" Box-Behnken design"> Box-Behnken design</a>, <a href="https://publications.waset.org/abstracts/search?q=factorial%20design" title=" factorial design"> factorial design</a> </p> <a href="https://publications.waset.org/abstracts/21542/response-surface-methodology-to-obtain-disopyramide-phosphate-loaded-controlled-release-ethyl-cellulose-microspheres" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/21542.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">458</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3451</span> Formulation and Evaluation of Niosomes Containing an Antihypertensive Drug</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sunil%20Kamboj">Sunil Kamboj</a>, <a href="https://publications.waset.org/abstracts/search?q=Suman%20Bala"> Suman Bala</a>, <a href="https://publications.waset.org/abstracts/search?q=Vipin%20Saini"> Vipin Saini</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Niosomes were formulated with an aim of enhancing the oral bioavailability of losartan potassium and formulated in different molar ratios of surfactant, cholesterol and dicetyl phosphate. The formulated niosomes were found in range of 54.98 µm to 107.85 µm in size. Formulations with 1:1 ratio of surfactant and cholesterol have shown maximum entrapment efficiencies. Niosomes with sorbitan monostearate showed maximum drug release and zero order release kinetics, at the end of 24 hours. The <em>in vivo</em> study has shown the significant enhancement in oral bioavailability of losartan potassium in rats, after a dose of 10 mg/kg. The average relative bioavailability in relation with pure drug solution was found 2.56, indicates more than two fold increase in oral bioavailability. A significant increment in MRT reflects the release retarding ability of the vesicles. In conclusion, niosomes could be a promising delivery of losartan potassium with improved oral bioavailability and prolonged release profiles. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=non-ionic%20surfactant%20vesicles" title="non-ionic surfactant vesicles">non-ionic surfactant vesicles</a>, <a href="https://publications.waset.org/abstracts/search?q=losartan%20potassium" title=" losartan potassium"> losartan potassium</a>, <a href="https://publications.waset.org/abstracts/search?q=oral%20bioavailability" title=" oral bioavailability"> oral bioavailability</a>, <a href="https://publications.waset.org/abstracts/search?q=controlled%20release" title=" controlled release"> controlled release</a> </p> <a href="https://publications.waset.org/abstracts/37426/formulation-and-evaluation-of-niosomes-containing-an-antihypertensive-drug" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/37426.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">354</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3450</span> Ceramide-PLGA Nanoparticle Formation to Apply to Atopic Dermatitis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sang-Myung%20Jung">Sang-Myung Jung</a>, <a href="https://publications.waset.org/abstracts/search?q=Gwang%20Heum%20%20Yoon"> Gwang Heum Yoon</a>, <a href="https://publications.waset.org/abstracts/search?q=Hoo%20Chul%20Lee"> Hoo Chul Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Hwa%20Sung%20Shin"> Hwa Sung Shin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Ceramide, a component of stratum corneum at epidermis, helps to construct a rigid and dense skin barrier to prevent pathogens that cause atopic dermatitis. However, ceramide was too hydrophobic to be directly absorbed into stratum corneum and has risks of side effects by excessive treatment. To overcome the obstacles, ceramide was embedded into PLGA nanoparticles coated with chitosan. PLGA and chitosan have been known as biocompatible materials. PLGA was squeezed when faced with water and pumped ceramide out of PLGA nanoparticle. In addition, the chitosan coating layer helped initial adherence of nanoparticles to skin and regulate ceramide release until removed. This coating was degraded at weakly acid state like skin surface, finally ceramide release could be controlled. Finally, the nanoparticle was demonstrated to be non-cytotoxic and regenerate stratum corneum of atopic dermatitis model. Overall the nanoparticle is suggested as a novel and effective nanodrug to apply atopic dermatitis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nanoparticle" title="nanoparticle">nanoparticle</a>, <a href="https://publications.waset.org/abstracts/search?q=controlled%20release" title=" controlled release"> controlled release</a>, <a href="https://publications.waset.org/abstracts/search?q=atopic%20dermatitis" title=" atopic dermatitis"> atopic dermatitis</a>, <a href="https://publications.waset.org/abstracts/search?q=chitosan%20coating" title=" chitosan coating"> chitosan coating</a>, <a href="https://publications.waset.org/abstracts/search?q=ceramide" title=" ceramide"> ceramide</a> </p> <a href="https://publications.waset.org/abstracts/50871/ceramide-plga-nanoparticle-formation-to-apply-to-atopic-dermatitis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/50871.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">394</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3449</span> Development of Oral Biphasic Drug Delivery System Using a Natural Resourced Polymer, Terminalia catappa</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Venkata%20Srikanth%20Meka">Venkata Srikanth Meka</a>, <a href="https://publications.waset.org/abstracts/search?q=Nur%20Arthirah%20Binti%20Ahmad%20Tarmizi%20Tan"> Nur Arthirah Binti Ahmad Tarmizi Tan</a>, <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Syahmi%20Bin%20Md%20Nazir"> Muhammad Syahmi Bin Md Nazir</a>, <a href="https://publications.waset.org/abstracts/search?q=Adinarayana%20Gorajana"> Adinarayana Gorajana</a>, <a href="https://publications.waset.org/abstracts/search?q=Senthil%20Rajan%20Dharmalingam"> Senthil Rajan Dharmalingam</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Biphasic drug delivery systems are designed to release drug at two different rates, either fast/prolonged or prolonged/fast. A fast/prolonged release system provides a burst drug release at initial stage followed by a slow release over a prolonged period of time and in case of prolonged/fast release system, the release pattern is vice versa. Terminalia catappa gum (TCG) is a natural polymer and was successfully proven as a novel pharmaceutical excipient. The main objective of the present research is to investigate the applicability of natural polymer, Terminalia catappa gum in the design of oral biphasic drug delivery system in the form of mini tablets by using a model drug, buspirone HCl. This investigation aims to produce a biphasic release drug delivery system of buspirone by combining immediate release and prolonged release mini tablets into a capsule. For immediate release mini tablets, a dose of 4.5 mg buspirone was prepared by varying the concentration of superdisintegrant; crospovidone. On the other hand, prolonged release mini tablets were produced by using different concentrations of the natural polymer; TCG with a buspirone dose of 3mg. All mini tablets were characterized for weight variation, hardness, friability, disintegration, content uniformity and dissolution studies. The optimized formulations of immediate and prolonged release mini tablets were finally combined in a capsule and was evaluated for release studies. FTIR and DSC studies were conducted to study the drug-polymer interaction. All formulations of immediate release and prolonged release mini tablets were passed all the in-process quality control tests according to US Pharmacopoeia. The disintegration time of immediate release mini tablets of different formulations was varied from 2-6 min, and maximum drug release was achieved in lesser than 60 min. Whereas prolonged release mini tablets made with TCG have shown good drug retarding properties. Formulations were controlled for about 4-10 hrs with varying concentration of TCG. As the concentration of TCG increased, the drug release retarding property also increased. The optimised mini tablets were packed in capsules and were evaluated for the release mechanism. The capsule dosage form has clearly exhibited the biphasic release of buspirone, indicating that TCG is a suitable natural polymer for this study. FTIR and DSC studies proved that there was no interaction between the drug and polymer. Based on the above positive results, it can be concluded that TCG is a suitable polymer for the biphasic drug delivery systems. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Terminalia%20catappa%20gum" title="Terminalia catappa gum">Terminalia catappa gum</a>, <a href="https://publications.waset.org/abstracts/search?q=biphasic%20release" title=" biphasic release"> biphasic release</a>, <a href="https://publications.waset.org/abstracts/search?q=mini%20tablets" title=" mini tablets"> mini tablets</a>, <a href="https://publications.waset.org/abstracts/search?q=tablet%20in%20capsule" title=" tablet in capsule"> tablet in capsule</a>, <a href="https://publications.waset.org/abstracts/search?q=natural%20polymers" title=" natural polymers"> natural polymers</a> </p> <a href="https://publications.waset.org/abstracts/50516/development-of-oral-biphasic-drug-delivery-system-using-a-natural-resourced-polymer-terminalia-catappa" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/50516.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">393</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3448</span> Preparation and Evaluation of Zidovudine Nanoparticles</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=D.%20R.%20Rama%20Brahma%20Reddy">D. R. Rama Brahma Reddy</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Vijaya%20Sarada%20Reddy"> A. Vijaya Sarada Reddy</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Nanoparticles represent a promising drug delivery system of controlled and targeted drug release. They are specially designed to release the drug in the vicinity of target tissue. The aim of this study was to prepare and evaluate polymethacrylic acid nanoparticles containing Zidovudine in different drug to polymer ratio by nanoprecipitation method. SEM indicated that nanoparticles have a discrete spherical structure without aggregation. The average particle size was found to be 120 ± 0.02 - 420 ± 0.05 nm. The particle size of the nanoparticles was gradually increased with increase in the proportion of polymethacrylic acid polymer. The drug content of the nanoparticles was increasing on increasing polymer concentration up to a particular concentration. No appreciable difference was observed in the extent of degradation of product during 60 days in which, nanoparticles were stored at various temperatures. FT-IR studies indicated that there was no chemical interaction between drug and polymer and stability of drug. The in-vitro release behavior from all the drug loaded batches was found to be zero order and provided sustained release over a period of 24 h. The developed formulation overcome and alleviates the drawbacks and limitations of Zidovudine sustained release formulations and could possibility be advantageous in terms of increased bio availability of Zidovudine. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nanoparticles" title="nanoparticles">nanoparticles</a>, <a href="https://publications.waset.org/abstracts/search?q=zidovudine" title=" zidovudine"> zidovudine</a>, <a href="https://publications.waset.org/abstracts/search?q=biodegradable" title=" biodegradable"> biodegradable</a>, <a href="https://publications.waset.org/abstracts/search?q=polymethacrylic%20acid" title=" polymethacrylic acid"> polymethacrylic acid</a> </p> <a href="https://publications.waset.org/abstracts/1479/preparation-and-evaluation-of-zidovudine-nanoparticles" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/1479.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">625</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=controlled%20release&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=controlled%20release&page=3">3</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=controlled%20release&page=4">4</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=controlled%20release&page=5">5</a></li> <li class="page-item"><a class="page-link" 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