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menu-item--expanded"> <a href="/research/science-areas/vaccine-immunity-and-cancer-directorate/hpv-and-covid-19-serology-laboratories">HPV and COVID-19 Serology Laboratories</a> </li> <li class="mega-menu-tree-item menu-item--expanded"> <a href="/research/science-areas/vaccine-immunity-and-cancer-directorate/seronet-coordinating-center">SeroNet Coordinating Center</a> </li> </ul> </li> </ul> <div class="mega-menu-content-highlight"> <div class="teaserHighlightWrapper"> <a href="/news/one-shot-hpv-vaccine-protects-long-term-against-cervical-cancer" class="teaserHighlightContent" > <img src="https://frederick.cancer.gov/sites/default/files/styles/thc_image/public/2025-04/Screenshot%202025-02-04%20at%2014.56.19.png?itok=yUUz3XvC" /> <div class="text-wrapper"> <span class="Kicker">HPV vaccine</span> <h3 class="Title">One shot of HPV vaccine protects long-term against cervical cancer</h3> <span class="Text">Study shows women should be safe from cancer-causing HPV for at least 20 years and probably more after just one dose of vaccine instead of the usual two or three.</span> </div> </a> </div> </div> </li> <li class="paragraph paragraph--type--mega-menu-section mega_menu_section_tree"> <span class="left-column-tab mega-menu-tree-toggler">Clinical Trial Support</span> <ul class="menu menu-level-2"> <li class="mega-menu-tree-item menu-item--expanded"> <span class="mega-menu-tree-toggler">Applied and Developmental Research Directorate</span> <ul class="menu menu-level-3"> <li class="mega-menu-tree-item menu-item--expanded"> <a href="/research/clinical-trial-support/applied-and-developmental-research-directorate">Program Overview</a> </li> <li class="mega-menu-tree-item menu-item--expanded"> <span class="mega-menu-tree-toggler">Clinical Services Program</span> <ul class="menu menu-level-4"> <li class="mega-menu-tree-item menu-item--expanded"> <a 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radial-gradient( 700px 700px at calc(50vw + 180px) calc(50% - 130px), rgb(0 0 0 / 0%) 0%, rgb(0 0 0 / 0%) 5%, rgb(107 210 200 / 20%) 60%, rgb(107 210 200 / 20%) 65%, rgb(0 0 0 / 100%) 100%), url('/sites/default/files/styles/homepage_feature_image/public/2025-04/MHL%20-%20Distal%20Femur%20using%20HALO%20analysis%20copy_0.png?itok=og-b-bL4');" > <div class="WidthContain"> <h1 class="homepage-hero-title"><span class="Kicker feature-kicker">Paving the Way for</span> Biomedical Innovation</h1> <div class="homepage-hero-text"><p>The Frederick National Laboratory meets the nation’s most urgent biomedical research needs and serves as a national and global resource for the scientific community. </p></div> <div class="gradient-pill-border cta-button"><a href="/about">Discover the Difference</a></div> <div class="views-element-container"><div class="homepage-feature-rotator view view-homepage-feature-rotator view-id-homepage_feature_rotator view-display-id-rotator_display 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the frequency at which different high-risk human papillomavirus (HPV) strains progress to cervical cancer and...</div> </div> </div> <div class="feature-slide"> <div data-history-node-id="7061" class="node node--type-news node--promoted node--view-mode-homepage-feature-rotator-slide"> <h3 class="slide-title"><a href="/news/simulations-implicate-structural-changes-culprit-mutant-proteins-cancer">Simulations implicate structural changes as a culprit in mutant protein’s cancer role and point to possible treatments </a></h3> <div class="slide-body-text">As Ruth Nussinov , Ph.D., and her team watched a mutated, cancer-causing protein twist and bend across their computer screen...</div> </div> </div> <div class="feature-slide"> <div data-history-node-id="7060" class="node node--type-news node--promoted node--view-mode-homepage-feature-rotator-slide"> <h3 class="slide-title"><a href="/news/drug-blocking-cancer-driving-ras-pi3k-pathway-enters-clinical-trials">Drug blocking cancer-driving RAS-PI3K pathway enters clinical trials </a></h3> <div class="slide-body-text">A new investigational drug co-developed by Frederick National Laboratory for Cancer Research (FNL) scientists blocks an...</div> </div> </div> <div class="feature-slide"> <div data-history-node-id="7059" class="node node--type-news node--promoted node--view-mode-homepage-feature-rotator-slide"> <h3 class="slide-title"><a href="/news/fnl-clinical-research-professionals-help-boost-enrollment-and-productivity">FNL clinical research professionals help boost enrollment, productivity for NCI-sponsored clinical trials via novel virtual initiative</a></h3> <div class="slide-body-text">Virtual support from Frederick National Laboratory for Cancer Research (FNL) clinical research professionals helps on-site...</div> </div> </div> <div class="feature-slide"> <div data-history-node-id="7056" class="node node--type-news node--promoted node--view-mode-homepage-feature-rotator-slide"> <h4 class="slide-kicker">Partnership 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But the consequences of unregulated diabetes on...</div> </div> </div> </div> </div> </div> </div> <div class="flyout-wrapper"> <div class="flyout-panel direction-up-left"> <span class="flyout-panel-header">What is this?</span> <span><p>Image of a distal mouse femur with mineralization scored via random forest classification using HALO image analysis software. The <a href="/research/science-areas/laboratory-animal-sciences-program/molecular-histopathology-laboratory">Molecular Histopathology Laboratory</a> investigates treatments for cancer and infectious diseases within the <a href="/research/science-areas/laboratory-animal-sciences-program">Laboratory Animal Sciences Program</a> by providing support for tissue-based research in understanding disease mechanisms, integrating research and diagnostic activities, and characterizing multiple mouse models of cancer.</p></span> </div> <span class="flyout-icon caption-info-icon">Information</span> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div id="" class="dms-row-wrapper dms-layout__background-position--cc dms-layout__background-size--cover" style="" > <div class="WidthContain"> <div class="dms-layout__row-width--100 dms-layout__row-padding-top--none dms-layout__row-padding-bottom--none row dms-layout__row dms-layout__row--one-column"> <div class="column 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class="field field--name-field-tag-line field--type-string field--label-hidden field__item"> <a href="https://frederick.cancer.gov/initiatives/center-innovation-and-strategic-partnerships">Cultivating innovation through technology development and partnerships </a> </div> <div class="field field--name-field-short-description field--type-string-long field--label-hidden field__item">We bring the Frederick National Laboratory’s distinct capabilities to the broader research community to help solve urgent problems in biomedical research. </div> <div class="field field--name-field-call-to-action-link field--type-link field--label-hidden field__item"> <div class="button-style-secondary green cta"> <a href="https://frederick.cancer.gov/initiatives/center-innovation-and-strategic-partnerships">Partner With Us</a> </div> </div> </div> </div> <div class="InitiativeStatistic"> <div class="WidthContain"> <div class="InitiativeStatisticInner"> <div class="field field--name-field-statistic-number field--type-integer field--label-hidden field__item">156</div> <div class="field field--name-field-statistic-text field--type-string-long field--label-hidden field__item">Cooperative Research and Development Agreements and CRADA amendments to enable and extend research projects between FNL scientists and external investigators.</div> </div> </div> </div> </div> <svg width="0" height="0" viewBox="0 0 1440 1000" version="1.1"> <defs> <clipPath id="initiativeClipPathWrap3567" clipPathUnits="objectBoundingBox" transform="scale(0.0006944444,0.001)" style="transform: scale(0.00069, 0.001);"> <path id="initiativeClipPath3567" class="st0" d="M0,303.4C353,260,801,170,1440,0.4v1000C1016,970,410,981,0,1000.4V303.4z"/> </clipPath> </defs> </svg> </article> </div> <div class="views-row"> <article data-history-node-id="5343" class="node node--type-initiative node--promoted node--view-mode-homepage-initiative InitiativeBlock initiative2928" data-uniqueSvgId="2928"> <div class="node__content"> <div class="InitiativeBody" style="background-image:url(https://frederick.cancer.gov/sites/default/files/styles/initiative_block/public/2023-04/MicrosoftTeams-image%20%2832%29.png?itok=7XfyVtSY); clip-path: url(#initiativeClipPathWrap2928)"> <div class="InitiativeInfo WidthContain"> <div class="InitiativePills"> <div class="InitiativeBundlePill"> <span class="Pill">Initiative</span> </div> <div class="DirectoratePill"> <a href="/node/385" class="Pill">Vaccine, Immunity, and Cancer Directorate</a> </div> </div> <h2> SeroNet </h2> <div class="field field--name-field-tag-line field--type-string field--label-hidden field__item"> <a href="/initiatives/seronet">Largest Coordinated Effort to Study COVID-19</a> </div> <div class="field field--name-field-short-description field--type-string-long field--label-hidden field__item">The Serological Sciences Network, or SeroNet, is a collaboration to enhance understanding of the immune response to the novel coronavirus, SARS-CoV-2. SeroNet supports research projects in basic and applied serological research related to COVID-19 and increasing the nation’s serological testing capacity.</div> <div class="field field--name-field-call-to-action-link field--type-link field--label-hidden field__item"> <div class="button-style-secondary green cta"> <a href="/initiatives/seronet">Learn More</a> </div> </div> </div> </div> <div class="InitiativeStatistic"> <div class="WidthContain"> <div class="InitiativeStatisticInner"> <div class="field field--name-field-statistic-number field--type-integer field--label-hidden field__item">170</div> <div class="field field--name-field-statistic-text field--type-string-long field--label-hidden field__item">U.S. SARS-CoV-2 Serology Standard requests from industry, government and academic laboratories worldwide.</div> </div> </div> </div> </div> <svg width="0" height="0" viewBox="0 0 1440 1000" version="1.1"> <defs> <clipPath id="initiativeClipPathWrap2928" clipPathUnits="objectBoundingBox" transform="scale(0.0006944444,0.001)" style="transform: scale(0.00069, 0.001);"> <path id="initiativeClipPath2928" class="st0" d="M0,303.4C353,260,801,170,1440,0.4v1000C1016,970,410,981,0,1000.4V303.4z"/> </clipPath> </defs> </svg> </article> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div id="" class="dms-row-wrapper dms-layout__background-position--cc dms-layout__background-size--cover HomeCareersSection FullWidthSection" style="" > <div class="WidthContain"> <div class="dms-layout__row-width--100 dms-layout__row-padding-top--medium dms-layout__row-padding-bottom--none row dms-layout__row dms-layout__row--one-column"> <div class="column column--first"> <div class="views-element-container block block-views block-views-blockhomepage-elements-redesign-homepage-careers"> <div><div class="homeCareersFancyBg view view-homepage-elements-redesign view-id-homepage_elements_redesign view-display-id-homepage_careers js-view-dom-id-c55ec58cc020e961301f2798efd4b980485c9a072bfc085133d94dbfa51cdf6b"> <div class="view-content"> <div class="views-row"><div><div class="CareersContentContainer"><h3 class="Kicker">Our Passion is Infectious</h3> <h2 class="Title">Shape Your Career</h2> <div class="CareerText"><p>Work with the best of the best biomedical researchers and investigators. 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Laboratory</span></a> </li> <li class="menu-item--_ac408ea-6fba-4d9e-9b86-ce206aa10718 menu-name--main"> <a href="/research/science-areas/vaccine-immunity-and-cancer-directorate/center-excellence-serology-development-and-emergency-preparedness" data-drupal-link-system-path="node/5898"><span>Center of Excellence for Serology Development and Emergency Preparedness</span></a> </li> <li class="menu-item--_397799f-ba67-4948-ab1e-69147b3e7f6e menu-name--main"> <a href="/research/science-areas/vaccine-immunity-and-cancer-directorate/hpv-and-covid-19-serology-laboratories" data-drupal-link-system-path="node/3721"><span>HPV and COVID-19 Serology Laboratories</span></a> </li> <li class="menu-item--a36afc72-070f-4aa9-8672-56264754ce87 menu-name--main"> <a href="/research/science-areas/vaccine-immunity-and-cancer-directorate/seronet-coordinating-center" data-drupal-link-system-path="node/5901"><span>SeroNet Coordinating Center</span></a> </li> </ul> </li> </ul> </li> <li class="menu-item--ff2d57ae-dda8-4fe4-b6e8-658f3cc2b688 menu-name--main"> <span><span>Clinical Trial Support</span></span> <ul> <li class="menu-item--_391ffd1-9e5a-475d-8411-ed5d06c2eed6 menu-name--main"> <a href="/research/clinical-trial-support/applied-and-developmental-research-directorate" data-drupal-link-system-path="node/5844"><span>Applied and Developmental Research Directorate</span></a> <ul> <li class="menu-item--fd583dfa-1e33-4ed3-afe7-c43b0f7732e9 menu-name--main"> <span><span>Clinical Services Program</span></span> <ul> <li class="menu-item--_c23eac4-b23a-44fc-85e8-c48b4951dc68 menu-name--main"> <a href="/research/clinical-trial-support/applied-and-developmental-research-directorate/clinical-services-program/aids-monitoring-laboratory" data-drupal-link-system-path="node/665"><span>AIDS Monitoring Laboratory</span></a> </li> <li class="menu-item--_ab52ed3-c3e6-4e95-a467-cbc30571a3cf menu-name--main"> <a href="/research/clinical-trial-support/applied-and-developmental-research-directorate/clinical-services-program/bioprocessing-laboratory" data-drupal-link-system-path="node/667"><span>Bioprocessing Laboratory</span></a> </li> <li class="menu-item--_50d4fa2-9aa9-4c61-9cc6-98fc12984a53 menu-name--main"> <a href="/research/clinical-trial-support/applied-and-developmental-research-directorate/clinical-services-program/blood-processing-core" data-drupal-link-system-path="node/669"><span>Blood Processing Core</span></a> </li> <li class="menu-item--_c84e525-17b2-4e42-bdb8-1ffdcf5fe2e9 menu-name--main"> <a href="/research/clinical-trial-support/applied-and-developmental-research-directorate/clinical-services-program/clinical-support-laboratory" data-drupal-link-system-path="node/671"><span>Clinical Support Laboratory</span></a> </li> <li class="menu-item--b958bb72-f62a-43d3-babe-29b7bbfb7c90 menu-name--main"> <a href="/research/clinical-trial-support/applied-and-developmental-research-directorate/clinical-services-program/flow-cytometry-support-laboratory" data-drupal-link-system-path="node/5924"><span>Flow Cytometry Support Laboratory</span></a> </li> <li class="menu-item--_062a052-d786-42e4-bc94-0929e2e8541a menu-name--main"> <a href="/research/clinical-trial-support/applied-and-developmental-research-directorate/clinical-services-program/immunological-monitoring-laboratory" data-drupal-link-system-path="node/675"><span>Immunological Monitoring Laboratory</span></a> </li> <li class="menu-item--aaa98f4d-91cb-49db-9840-8e163e1e9da8 menu-name--main"> <a href="/research/clinical-trial-support/applied-and-developmental-research-directorate/clinical-services-program/laboratory-human-retrovirology-and" data-drupal-link-system-path="node/677"><span>Laboratory of Human Retrovirology and Immunoinformatics</span></a> </li> <li class="menu-item--_527911b-871a-4438-8f65-9a803c9c3c7e menu-name--main"> <a href="/research/clinical-trial-support/applied-and-developmental-research-directorate/clinical-services-program/laboratory-molecular-cell-biology" data-drupal-link-system-path="node/679"><span>Laboratory of Molecular Cell Biology</span></a> </li> <li class="menu-item--_1b8d1b9-1f64-4e23-985b-1044860c212b menu-name--main"> <a href="/research/clinical-trial-support/applied-and-developmental-research-directorate/clinical-services-program/neutrophil-monitoring-laboratory" data-drupal-link-system-path="node/680"><span>Neutrophil Monitoring Laboratory</span></a> </li> <li class="menu-item--_b7ff125-92b0-46c6-b390-f5f5bbfa13d2 menu-name--main"> <a href="/research/clinical-trial-support/applied-and-developmental-research-directorate/clinical-services-program/radiochemistry-program" data-drupal-link-system-path="node/5910"><span>Radiochemistry Program</span></a> </li> <li class="menu-item--_4b228e2-0a48-47f8-840e-c0792c6e660e menu-name--main"> <a href="/research/clinical-trial-support/applied-and-developmental-research-directorate/clinical-services-program/virus-isolation-and-serology-laboratory" data-drupal-link-system-path="node/684"><span>Virus Isolation and Serology Laboratory</span></a> </li> </ul> </li> <li class="menu-item--e83b133d-e900-416f-8c7a-71ee225a7d6f menu-name--main"> <span><span>DCTD Support</span></span> <ul> <li class="menu-item--_64675cc-2122-4290-b6f2-6bd9e54fe7bc menu-name--main"> <a href="/research/clinical-trial-support/applied-and-developmental-research-directorate/dctd-support/cancer-imaging-informatics-laboratory" data-drupal-link-system-path="node/5925"><span>Cancer Imaging Informatics Laboratory</span></a> </li> <li class="menu-item--_41732d6-67d9-48f8-a8c8-7274de1293e6 menu-name--main"> <a href="/research/clinical-trial-support/applied-and-developmental-research-directorate/dctd-support/clinical-pharmacodynamics-biomarkers-program" data-drupal-link-system-path="node/5955"><span>Clinical Pharmacodynamics - Biomarkers Program</span></a> </li> <li class="menu-item--d6de0a32-67e3-4790-af36-60dc2f51d499 menu-name--main"> <a href="/research/clinical-trial-support/applied-and-developmental-research-directorate/dctd-support/vitro-evaluation-and-molecular-pharmacology-laboratories" data-drupal-link-system-path="node/5908"><span>In Vitro Evaluation and Molecular Pharmacology Laboratories</span></a> </li> <li class="menu-item--_9e33ecb-67c4-4e3d-b651-6e99f51d057c menu-name--main"> <a href="/research/clinical-trial-support/applied-and-developmental-research-directorate/dctd-support/vivo-evaluation-program" data-drupal-link-system-path="node/5914"><span>In Vivo Evaluation Program</span></a> </li> <li class="menu-item--_7dddcba-d606-4205-b1d0-df8753228bf4 menu-name--main"> <a href="/research/clinical-trial-support/applied-and-developmental-research-directorate/dctd-support/investigative-toxicology-laboratory" data-drupal-link-system-path="node/5922"><span>Investigative Toxicology Laboratory</span></a> </li> <li class="menu-item--_e9247a5-8c91-4e87-846a-564bd8d3d4dc menu-name--main"> <a href="/research/clinical-trial-support/applied-and-developmental-research-directorate/dctd-support/next-chemical-biology-consortium-support-programs" data-drupal-link-system-path="node/5912"><span>NExT Chemical Biology Consortium Support Programs</span></a> </li> <li class="menu-item--e8c4e20d-70aa-4b71-a74d-0eece13ad480 menu-name--main"> <a href="/research/clinical-trial-support/applied-and-developmental-research-directorate/dctd-support/natural-products-support-group" data-drupal-link-system-path="node/5919"><span>Natural Products Support Group</span></a> </li> <li class="menu-item--_4fa0ed8-fda7-4abf-b792-7539782b4d9d menu-name--main"> <a href="/research/clinical-trial-support/applied-and-developmental-research-directorate/dctd-support/pharmacokinetics-and-drug-analysis-group" data-drupal-link-system-path="node/5941"><span>Pharmacokinetics and Drug Analysis Group</span></a> </li> <li class="menu-item--_50bc24f-1786-4d41-a9e0-abfeb84b89c2 menu-name--main"> <a href="/research/clinical-trial-support/applied-and-developmental-research-directorate/dctd-support/radiochemistry-support-group" data-drupal-link-system-path="node/682"><span>Radiochemistry Support Group</span></a> </li> </ul> </li> </ul> </li> <li class="menu-item--a884ac56-b205-4621-a247-3d5b86058359 menu-name--main"> <a href="/research/clinical-trial-support/biopharmaceutical-development-program" data-drupal-link-system-path="node/663"><span>Biopharmaceutical Development Program</span></a> </li> <li class="menu-item--_29caa5a-450b-43f2-bd87-9e2e3eb836c1 menu-name--main"> <a href="/research/clinical-trial-support/clinical-monitoring-research-program" data-drupal-link-system-path="node/379"><span>Clinical Monitoring Research Program</span></a> </li> <li class="menu-item--_86fe08d-2422-4e6f-99d7-b6ebb14d00d3 menu-name--main"> <a href="/research/clinical-trial-support/clinical-research-directorate" data-drupal-link-system-path="node/5856"><span>Clinical Research Directorate</span></a> <ul> <li class="menu-item--c9ad8f4d-b2c9-492f-95ae-cc94dd0ad04f menu-name--main"> <a href="/research/clinical-trial-support/clinical-research-directorate/biospecimen-research-group" data-drupal-link-system-path="node/5943"><span>Biospecimen Research Group</span></a> </li> <li class="menu-item--_a5f2e2d-34e8-4496-9c20-dc5a72fb60b6 menu-name--main"> <a href="/research/clinical-trial-support/clinical-research-directorate/cancer-genomics-research-laboratory" data-drupal-link-system-path="node/5951"><span>Cancer Genomics Research Laboratory</span></a> </li> <li class="menu-item--ee83a817-f8f8-422e-a962-885b772c86c6 menu-name--main"> <a href="/research/clinical-trial-support/clinical-research-directorate/drug-discovery-and-development-program" data-drupal-link-system-path="node/5905"><span>Drug Discovery and Development Program</span></a> </li> <li class="menu-item--_3e6d465-91d4-4470-9fd3-f29b9ed04ccb menu-name--main"> <a href="/research/clinical-trial-support/clinical-research-directorate/molecular-characterization-laboratory" data-drupal-link-system-path="node/421"><span>Molecular Characterization Laboratory</span></a> </li> </ul> </li> <li class="menu-item--_bcd8f02-bc77-4cc7-b06e-980f1cd8a5dd menu-name--main"> <a href="/research/clinical-trial-support/vaccine-clinical-materials-program" data-drupal-link-system-path="node/411"><span>Vaccine Clinical Materials Program</span></a> </li> </ul> </li> </ul> </li> <li class="menu-item--_894b59d-f812-4ea6-80ea-991b84c5e6b6 menu-name--main"> <span><span>Innovation & Initiatives</span></span> <ul> <li class="menu-item--_426a5f1-8301-4450-a4c1-efbb2f0dd40b menu-name--main"> <span><span>Initiatives</span></span> <ul> <li class="menu-item--a733e821-4b4f-439a-83e0-9cbec2a0c97c menu-name--main"> <a href="/initiatives/ras-initiative" data-drupal-link-system-path="node/5342"><span>RAS Initiative</span></a> </li> <li 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