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A prospective study of HER3 expression pre and post neoadjuvant therapy of different breast cancer subtypes: implications for HER3 imaging therapy guidance - PubMed
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data-collections-open-panel-url-hash="#open-collections-panel"> <div class="inner-wrap"> <h3 class="action-panel-heading"> Add to Collections </h3> <form id="collections-action-panel-form" class="collections-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-existing-collections-url="/list-existing-collections/" data-add-to-existing-collection-url="/add-to-existing-collection/" data-create-and-add-to-new-collection-url="/create-and-add-to-new-collection/" data-get-article-ids-by-search-url="/get-article-ids-by-search/" data-myncbi-max-collection-name-length="100" data-add-to-collection-max-amount="1000" data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/"> <input type="hidden" name="csrfmiddlewaretoken" value="yLFYCgK5Qh3h1aN7yKCxNHq1226oZ0hWtRv2mNG4ZxFv5x7PbHFilYu5Q72MJYPc"> <div class="choice-group" role="radiogroup"> <ul class="radio-group-items"> <li> <input type="radio" id="collections-action-panel-new" class="collections-new" name="collections" value="new" data-ga-category="save_share" data-ga-action="collections" data-ga-label="collections_radio_new"> <label for="collections-action-panel-new">Create a new collection</label> </li> <li> <input type="radio" id="collections-action-panel-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="save_share" data-ga-action="collections" data-ga-label="collections_radio_existing"> <label for="collections-action-panel-existing">Add to an existing collection</label> </li> </ul> </div> <div class="controls-wrapper"> <div class="action-panel-control-wrap new-collections-controls"> <label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label> <input type="text" name="add-to-new-collection" id="collections-action-panel-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="save_share" data-ga-action="create_collection" data-ga-label="non_favorties_collection"> <div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div> </div> <div class="action-panel-control-wrap existing-collections-controls"> <label for="collections-action-panel-add-to-existing" class="action-panel-label"> Choose a collection: </label> <select id="collections-action-panel-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="save_share" data-ga-action="select_collection" data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"> </select> <div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br> <a href="#">Please try again</a> </div> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="save_share" data-ga-action="collections" data-ga-label="add"> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="collections" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="bibliography-action-panel" class="bibliography-action-panel action-panel in-progress-dots-panel" aria-hidden="true" data-bibliography-open-panel-enabled="false" data-bibliography-open-panel-url-hash="#open-bibliography-panel"> <div class="inner-wrap"> <h3 class="action-panel-heading"> Add to My Bibliography </h3> <form id="bibliography-action-panel-form" class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-add-to-bibliography-max-amount="100" data-add-to-bibliography-batch-size="10" data-bibliography-delegates-url="/list-bibliography-delegates/" data-add-to-bibliography-url="/add-to-bibliography/" data-get-article-ids-by-search-url="/get-article-ids-by-search/" data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/"> <input type="hidden" name="csrfmiddlewaretoken" value="yLFYCgK5Qh3h1aN7yKCxNHq1226oZ0hWtRv2mNG4ZxFv5x7PbHFilYu5Q72MJYPc"> <div class="action-panel-control-wrap bibliographies-controls"> <div class="choice-group"> <ul class="bibliographies-action-add radio-group-items"> <li> <input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/> <label for="my-bibliography">My Bibliography</label> </li> </ul> </div> </div> <div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your delegates due to an error<br> <a href="#">Please try again</a> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to bibliography' panel" ref="linksrc=close_bibliography_panel" aria-controls="bibliography-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="mybib" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true" data-saved-search-open-panel-enabled="false" data-saved-search-open-panel-url-hash="#open-saved-search-panel"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your saved search </h2> <form id="saved-search-action-panel-form" class="saved-search-action-panel-form action-panel-content action-form" data-create-saved-search-url="/create-saved-search/" data-try-search-terms-url="/try-search-term/" data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/"> <input type="hidden" name="csrfmiddlewaretoken" value="yLFYCgK5Qh3h1aN7yKCxNHq1226oZ0hWtRv2mNG4ZxFv5x7PbHFilYu5Q72MJYPc"> <div class="action-panel-control-wrap"> <label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk"> Name of saved search: </label> <input maxlength="200" type="text" name="saved-search-name" id="saved-search-name" class="saved-search-name" value="" required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="action-panel-control-wrap"> <label for="saved-search-term" class="action-panel-label required-field-asterisk"> Search terms: </label> <textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea> </div> <div class="test-search-term-wrap"> <a href="#" class="try-search-term">Test search terms</a> </div> <div class="choice-group action-panel-extra-margin-top"> <span class="action-panel-label" id="fieldset-label"> Would you like email updates of new search results? </span> <fieldset id="saved-search-alert" aria-describedby="fieldset-label"> <legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend> <ul class="radio-group-items"> <li> <input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked> <label for="saved-search-alert-yes" class="action-panel-label">Yes</label> </li> <li> <input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no"> <label for="saved-search-alert-no" class="action-panel-label">No</label> </li> </ul> </fieldset> </div> <div class="alert-schedule-wrap"> <div class="action-panel-control-wrap"> <label class="action-panel-label"> Email: </label> <span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span> </div> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="saved-search-frequency" class="action-panel-label"> Frequency: </label> <select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency"> <option value="monthly">Monthly</option> <option value="weekly">Weekly</option> <option value="daily">Daily</option> </select> </div> <div class="action-panel-control-wrap saved-search-monthly-additional"> <label for="saved-search-monthly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-monthly-on-day" class="no-border-panel-selector"> <option value="Sunday">The first Sunday</option> <option value="Monday">The first Monday</option> <option value="Tuesday">The first Tuesday</option> <option value="Wednesday">The first Wednesday</option> <option value="Thursday">The first Thursday</option> <option value="Friday">The first Friday</option> <option value="Saturday">The first Saturday</option> <option value="day">The first day</option> <option value="weekday">The first weekday</option> </select> </div> <div class="action-panel-control-wrap saved-search-weekly-additional"> <label for="saved-search-weekly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day"> <option value="Sunday">Sunday</option> <option value="Monday">Monday</option> <option value="Tuesday">Tuesday</option> <option value="Wednesday">Wednesday</option> <option value="Thursday">Thursday</option> <option value="Friday">Friday</option> <option value="Saturday">Saturday</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-report" class="action-panel-label"> Report format: </label> <select id="saved-search-report" class="no-border-panel-selector saved-search-report"> <option value="DocSum">Summary</option> <option value="DocSumText">Summary (text)</option> <option value="Abstract">Abstract</option> <option value="AbstractText">Abstract (text)</option> <option value="MEDLINE">PubMed</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-amount" class="action-panel-label"> Send at most: </label> <select id="saved-search-amount" class="no-border-panel-selector saved-search-amount"> <option value="1">1 item</option> <option value="5" selected>5 items</option> <option value="10">10 items</option> <option value="20">20 items</option> <option value="50">50 items</option> <option value="100">100 items</option> <option value="200">200 items</option> </select> </div> <div> <input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result"> <label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox"> Send even when there aren't any new results </label> </div> <div class="action-panel-control-wrap option-text-in-email-wrap"> <label for="saved-search-email-text" class="action-panel-label"> Optional text in email: </label> <textarea name="saved-search-email-text" id="saved-search-email-text" class="saved-search-email-text"></textarea> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Saving..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Save </button> <button class="action-panel-cancel" aria-label="Close 'Your saved search' panel" ref="linksrc=close_saved_search_panel" aria-controls="saved-search-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Create a file for external citation management software </h2> <form id="citation-manager-action-panel-form" class="action-panel-content action-form" action="/results-export-ids/" data-by-search-action="/results-export-search-data/" data-by-ids-action="/results-export-ids/" method="post" data-by-search-method="post" data-by-ids-method="post"> <input type="hidden" name="csrfmiddlewaretoken" value="yLFYCgK5Qh3h1aN7yKCxNHq1226oZ0hWtRv2mNG4ZxFv5x7PbHFilYu5Q72MJYPc"> <input name="results-format" type="hidden" value="pubmed"/> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Sending..." data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="save"> Create file </button> <button class="action-panel-cancel" aria-label="Close 'Send citations to citation manager' panel" ref="linksrc=close_citation_manager_panel" aria-controls="citation-manager-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your RSS Feed </h2> <form id="rss-action-panel-form" class="rss-action-panel-form action-panel-content action-form" data-create-rss-feed-url="/create-rss-feed-url/" data-search-form-term-value=""> <input type="hidden" name="csrfmiddlewaretoken" value="yLFYCgK5Qh3h1aN7yKCxNHq1226oZ0hWtRv2mNG4ZxFv5x7PbHFilYu5Q72MJYPc"> <div class="action-panel-control-wrap"> <label for="rss-name" class="action-panel-label required-field-asterisk"> Name of RSS Feed: </label> <input maxlength="200" placeholder="Name" type="text" name="rss-name" id="rss-name" class="rss-name" value='' required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="rss-limit-wrap"> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="rss-limit" class="action-panel-label"> Number of items displayed: </label> <select id="rss-limit" class="no-border-panel-selector rss-limit"> <option value="5">5</option> <option value="10">10</option> <option value="15" selected="selected">15</option> <option value="20">20</option> <option value="50">50</option> <option value="100">100</option> </select> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Creating..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Create RSS </button> 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id="full-view-journal" class="journal-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for journal Breast cancer research : BCR"><div class="title">Actions</div><div class="content"><ul class="journal-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Breast+Cancer+Res%22%5Bjour%5D&sort=date&sort_order=desc" data-href="/?term=%22Breast+Cancer+Res%22%5Bjour%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_journal_name_link&journal_abbrev=Breast Cancer Res" data-ga-category="search" data-ga-action="journal_link" data-ga-label="Breast Cancer Res"> Search in PubMed </a></li><li><a class="search-in-nlm-catalog-link dropdown-block-link" ref ="linksrc=search_in_nlm_catalog_link" href="https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Breast+Cancer+Res%22%5BTitle+Abbreviation%5D" data-ga-category="search_catalog" data-ga-action="journal_link" data-ga-label="Breast Cancer Res"> Search in NLM Catalog </a></li><li><a class="add-to-search-link dropdown-block-link" ref ="linksrc=add_to_search_link" role="button" data-search-term='"Breast Cancer Res"[jour]' data-ga-category="search" data-ga-action="add_to_search" data-ga-label='"Breast Cancer Res"[jour]' href="#"> Add to Search </a></li></ul></div></div></div><span class="period">. </span><span class="cit">2024 Jun 29;26(1):107.</span> </div> <span class="citation-doi"> doi: 10.1186/s13058-024-01859-w. </span> </div> <h1 class="heading-title"> A prospective study of HER3 expression pre and post neoadjuvant therapy of different breast cancer subtypes: implications for HER3 imaging therapy guidance </h1> <div class="inline-authors"> <div class="authors"> <div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Sinevici+N&cauthor_id=38951909" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Nicoleta Sinevici">Nicoleta Sinevici</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Boston, MA, USA." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Edmonds+CE&cauthor_id=38951909" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Christine E Edmonds">Christine E Edmonds</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Boston, MA, USA." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Dontchos+BN&cauthor_id=38951909" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Brian N Dontchos">Brian N Dontchos</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Boston, MA, USA." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Wang+G&cauthor_id=38951909" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Gary Wang">Gary Wang</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Boston, MA, USA." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Lehman+CD&cauthor_id=38951909" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Constance D Lehman">Constance D Lehman</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Boston, MA, USA." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Isakoff+S&cauthor_id=38951909" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Steven Isakoff">Steven Isakoff</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Hematology and Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA." href="#full-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Mahmood+U&cauthor_id=38951909" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Umar Mahmood">Umar Mahmood</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Boston, MA, USA. umahmood@mgh.harvard.edu." href="#full-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup></span> </div> </div> </div> <div class="short-article-details"> Affiliations <button class="more-details" id="toggle-authors" data-alt-text="Collapse" aria-controls="expanded-authors" aria-expanded="false" data-pinger-ignore data-fetch-url="/38951909/long-authors/" 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umahmood@mgh.harvard.edu.</li> </ul> </div> </div> </div> <ul class="identifiers" id="full-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">38951909</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=PMC11218108&id_type=PMC" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC11218108/" data-ga-category="full_text" data-ga-action="PMCID" > PMC11218108 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1186/s13058-024-01859-w&id_type=DOI" href="https://doi.org/10.1186/s13058-024-01859-w" data-ga-category="full_text" data-ga-action="DOI" > 10.1186/s13058-024-01859-w </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> <div class="short-view" id="short-view-heading"> <h1 class="heading-title"> A prospective study of HER3 expression pre and post neoadjuvant therapy of different breast cancer subtypes: implications for HER3 imaging therapy guidance </h1> <div class="short-citation"> <span class="authors-list"> <span class="authors-list-item "><span class="full-name">Nicoleta Sinevici</span><span class="citation-separator"> et al.</span></span> </span> <span class="citation-journal"> Breast Cancer Res<span class="citation-separator">.</span> </span> <span class="date"> <time class="citation-year" datetime="2024">2024</time><span class="citation-separator">.</span> </span> </div> <div class="more-article-details-section with-display-settings"> <button class="more-article-details" id="toggle-article-details" data-alt-text="Hide details" ref="linksrc=toggle_article_details" aria-controls="full-article-details" aria-expanded="false" data-fetch-url="/38951909/long-authors/" 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class="journal-actions dropdown-block"><button id="short-view-journal-trigger" class="journal-actions-trigger trigger" ref="linksrc=journal_actions_btn" title="Breast cancer research : BCR" tabindex="0" aria-controls="short-view-journal" aria-expanded="false" aria-label="Toggle dropdown menu for journal Breast cancer research : BCR" data-pinger-ignore> Breast Cancer Res </button><div id="short-view-journal" class="journal-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for journal Breast cancer research : BCR"><div class="title">Actions</div><div class="content"><ul class="journal-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Breast+Cancer+Res%22%5Bjour%5D&sort=date&sort_order=desc" data-href="/?term=%22Breast+Cancer+Res%22%5Bjour%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_journal_name_link&journal_abbrev=Breast Cancer Res" data-ga-category="search" data-ga-action="journal_link" data-ga-label="Breast Cancer Res"> Search in PubMed </a></li><li><a class="search-in-nlm-catalog-link dropdown-block-link" ref ="linksrc=search_in_nlm_catalog_link" href="https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Breast+Cancer+Res%22%5BTitle+Abbreviation%5D" data-ga-category="search_catalog" data-ga-action="journal_link" data-ga-label="Breast Cancer Res"> Search in NLM Catalog </a></li><li><a class="add-to-search-link dropdown-block-link" ref ="linksrc=add_to_search_link" role="button" data-search-term='"Breast Cancer Res"[jour]' data-ga-category="search" data-ga-action="add_to_search" data-ga-label='"Breast Cancer Res"[jour]' href="#"> Add to Search </a></li></ul></div></div></div><span class="period">. </span><span class="cit">2024 Jun 29;26(1):107.</span> </div> <span class="citation-doi"> doi: 10.1186/s13058-024-01859-w. </span> </div> <div class="expanded-authors" id="short-view-expanded-authors"> <div class="authors"> <h3 class="title"> Authors </h3> <div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Sinevici+N&cauthor_id=38951909" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Nicoleta Sinevici">Nicoleta Sinevici</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Boston, MA, USA." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Edmonds+CE&cauthor_id=38951909" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Christine E Edmonds">Christine E Edmonds</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Boston, MA, USA." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Dontchos+BN&cauthor_id=38951909" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Brian N Dontchos">Brian N Dontchos</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Boston, MA, USA." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Wang+G&cauthor_id=38951909" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Gary Wang">Gary Wang</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Boston, MA, USA." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Lehman+CD&cauthor_id=38951909" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Constance D Lehman">Constance D Lehman</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Boston, MA, USA." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Isakoff+S&cauthor_id=38951909" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Steven Isakoff">Steven Isakoff</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Hematology and Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA." href="#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Mahmood+U&cauthor_id=38951909" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Umar Mahmood">Umar Mahmood</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Boston, MA, USA. umahmood@mgh.harvard.edu." href="#short-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup></span> </div> </div> <div class="affiliations"> <h3 class="title"> Affiliations </h3> <ul class="item-list"> <li data-affiliation-id="short-view-affiliation-1" id="short-view-affiliation-1" ><sup class="key">1</sup> Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Boston, MA, USA.</li> <li data-affiliation-id="short-view-affiliation-2" id="short-view-affiliation-2" ><sup class="key">2</sup> Department of Hematology and Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.</li> <li data-affiliation-id="short-view-affiliation-3" id="short-view-affiliation-3" ><sup class="key">3</sup> Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Boston, MA, USA. umahmood@mgh.harvard.edu.</li> </ul> </div> </div> <ul class="identifiers" id="short-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">38951909</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=PMC11218108&id_type=PMC" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC11218108/" data-ga-category="full_text" data-ga-action="PMCID" > PMC11218108 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1186/s13058-024-01859-w&id_type=DOI" href="https://doi.org/10.1186/s13058-024-01859-w" data-ga-category="full_text" data-ga-action="DOI" > 10.1186/s13058-024-01859-w </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> </div> </header> <div class="actions-buttons inline"><div class="inner-wrap"><button class="full-text-links-button 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class="title"> Display options </div><div class="content"><div class="format-container"><span class="option-label"> Format </span><select name="format" data-initial-value="abstract" aria-label="Display format" id="inline-actions-display-format"><option value="abstract">Abstract</option><option value="pubmed">PubMed</option><option value="pmid">PMID</option></select></div></div></div></div></div></div> <div class="abstract" id="abstract"> <h2 class="title"> Abstract </h2> <div class="abstract-content selected" id="eng-abstract"> <p> <strong class="sub-title"> Purpose: </strong> HER3, a member of the EGFR receptor family, plays a central role in driving oncogenic cell proliferation in breast cancer. Novel HER3 therapeutics are showing promising results while recently developed HER3 PET imaging modalities aid in predicting and assessing early treatment response. However, baseline HER3 expression, as well as changes in expression while on neoadjuvant therapy, have not been well-characterized. We conducted a prospective clinical study, pre- and post-neoadjuvant/systemic therapy, in patients with newly diagnosed breast cancer to determine HER3 expression, and to identify possible resistance mechanisms maintained through the HER3 receptor. </p> <p> <strong class="sub-title"> Experimental design: </strong> The study was conducted between May 25, 2018 and October 12, 2019. Thirty-four patients with newly diagnosed breast cancer of any subtype (ER ± , PR ± , HER2 ±) were enrolled in the study. Two core biopsy specimens were obtained from each patient at the time of diagnosis. Four patients underwent a second research biopsy following initiation of neoadjuvant/systemic therapy or systemic therapy which we define as neoadjuvant therapy. Molecular characterization of HER3 and downstream signaling nodes of the PI3K/AKT and MAPK pathways pre- and post-initiation of therapy was performed. Transcriptional validation of finings was performed in an external dataset (GSE122630). </p> <p> <strong class="sub-title"> Results: </strong> Variable baseline HER3 expression was found in newly diagnosed breast cancer and correlated positively with pAKT across subtypes (r = 0.45). In patients receiving neoadjuvant/systemic therapy, changes in HER3 expression were variable. In a hormone receptor-positive (ER +/PR +/HER2-) patient, there was a statistically significant increase in HER3 expression post neoadjuvant therapy, while there was no significant change in HER3 expression in a ER +/PR +/HER2+ patient. However, both of these patients showed increased downstream signaling in the PI3K/AKT pathway. One subject with ER +/PR -/HER2- breast cancer and another subject with ER +/PR +/HER2 + breast cancer showed decreased HER3 expression. Transcriptomic findings, revealed an immune suppressive environment in patients with decreased HER3 expression post therapy. </p> <p> <strong class="sub-title"> Conclusion: </strong> This study demonstrates variable HER3 expression across breast cancer subtypes. HER3 expression can be assessed early, post-neoadjuvant therapy, providing valuable insight into cancer biology and potentially serving as a prognostic biomarker. Clinical translation of neoadjuvant therapy assessment can be achieved using HER3 PET imaging, offering real-time information on tumor biology and guiding personalized treatment for breast cancer patients. </p> </div> <p> <strong class="sub-title"> Keywords: </strong> Breast cancer; HER3; Imaging; Immune suppressive; Neoadjuvant; Resistance; Therapy. </p> </div> <p class="copyright" id="copyright"> © 2024. The Author(s). </p> <p class="disclaimer" id="disclaimer"> <a href="/disclaimer/" target="_blank" ga_category="literature_resources" ga_action="disclaimer_link" ga_label="under_abstract">PubMed Disclaimer</a> </p> <div class="conflict-of-interest" id="conflict-of-interest"> <h2 class="title"> Conflict of interest statement </h2> <div class="statement"> <p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">All authors declare that they have no competing interests.</p> </div> </div> <div class="figures" id="figures"> <h2 class="title"> Figures </h2> <div class="figures-list" id="slides-container" itemscope itemtype="http://schema.org/ImageGallery"> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="0" data-label-slug="fig-1"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9573/11218108/77f8f6bdc8a4/13058_2024_1859_Fig1_HTML.jpg" itemprop="contentUrl" aria-describedby="figure-caption-0" role="button" data-image-width="784" data-image-height="677" data-image-alt="Fig. 1" data-pmc-id="PMC11218108" data-figure-id="Fig1"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-0" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9573/11218108/7828ffb0092e/13058_2024_1859_Fig1_HTML.gif" alt="Fig. 1" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="784"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="677"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Fig. 1 </p> </strong> <div class="figure-caption-contents"><p> Survival analysis in the context… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Fig. 1 </p> </strong> <div class="figure-caption-contents"><p> Survival analysis in the context of HER3 gene alteration. <b> A </b> Kaplan–Meier plots for… </p></div> </div> <figcaption id="figure-caption-0" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Fig. 1 </strong> <div class="figure-caption-contents">Survival analysis in the context of HER3 gene alteration. <b>A</b> Kaplan–Meier plots for disease-specific, progression free and overall survival of breast cancer showing HER3 gene alterations from 221 patients across 16 studies, using cBioPortal. <b>B</b> Mutation frequency in percentage of genes associated with HER3 gene signatures in breast cancer <b>C</b> alterations in EGFR, HER2, HER3 and ESR1 gene expression tendencies from patients with breast cancer <b>D</b> schematic representation of pathway signalling in patients with HER3 gene signature. Data was generated in (<ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://cbioportal.org">http://cbioportal.org</ext-link>)</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="1" data-label-slug="fig-2"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9573/11218108/6802be8766d4/13058_2024_1859_Fig2_HTML.jpg" itemprop="contentUrl" aria-describedby="figure-caption-1" role="button" data-image-width="783" data-image-height="763" data-image-alt="Fig. 2" data-pmc-id="PMC11218108" data-figure-id="Fig2"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-1" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9573/11218108/bf534b53f7d5/13058_2024_1859_Fig2_HTML.gif" alt="Fig. 2" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="783"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="763"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Fig. 2 </p> </strong> <div class="figure-caption-contents"><p> HER3 is variably expressed across… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Fig. 2 </p> </strong> <div class="figure-caption-contents"><p> HER3 is variably expressed across different breast cancer subtypes at diagnosis. <b> A </b> Relative… </p></div> </div> <figcaption id="figure-caption-1" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Fig. 2 </strong> <div class="figure-caption-contents">HER3 is variably expressed across different breast cancer subtypes at diagnosis. <b>A</b> Relative protein expression of HER3 in patients (n = 34) diagnosed with breast tumors and classified by hormone receptor and HER2 expression subtype with <b>B</b> mean HER3 expression based on receptor status and <b>C</b> patient frequency of low and high HER3 expressing tumors <b>D</b> Distribution of patients based on specific hormone status <b>E</b> Representative immunoblots of HER3 family receptors and downstream signaling demonstrating variable HER3 involvement in these breast cancer patients <b>F</b> Pearson correlation analysis showing a positive correlation between HER3 expression and phosphorylation of AKT in breast cancer patients <b>G</b> Pearson correlation between HER3 and phosphorylation of AKT as classified by intrinsic breast cancer subtype and <b>H</b> representative immunohistofluorescence analysis of HER3 expressing and non HER3 expressing breast cancer biopsies</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="2" data-label-slug="fig-3"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9573/11218108/ff00cde9fc70/13058_2024_1859_Fig3_HTML.jpg" itemprop="contentUrl" aria-describedby="figure-caption-2" role="button" data-image-width="784" data-image-height="440" data-image-alt="Fig. 3" data-pmc-id="PMC11218108" data-figure-id="Fig3"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-2" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9573/11218108/fd2269dd9ae3/13058_2024_1859_Fig3_HTML.gif" alt="Fig. 3" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="784"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="440"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Fig. 3 </p> </strong> <div class="figure-caption-contents"><p> HER3 increases after neoadjuvant therapy… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Fig. 3 </p> </strong> <div class="figure-caption-contents"><p> HER3 increases after neoadjuvant therapy in some but not all breast cancer tumors.… </p></div> </div> <figcaption id="figure-caption-2" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Fig. 3 </strong> <div class="figure-caption-contents">HER3 increases after neoadjuvant therapy in some but not all breast cancer tumors. <b>A</b> Patient characteristics and neoadjuvant regimens given <b>B</b> Representative immunoblots of HER3 and downstream signaling in patients pre and post neoadjuvant therapy and <b>C</b> Quantitative analysis of changes in these protein targets demonstrating variable response in the HER3 expression (n = 3). Data was analyzed using ANOVA analysis <b>D</b> Immunohistofluorescence of HER3 in patients receiving neoadjuvant therapy and <b>E</b> corresponding quantification analyzed using T-tests. *<i>P</i> < 0.05; **<i>P</i> < 0.01, ***<i>P</i> < 0.001, *****<i>P</i> < 0.0001</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="3" data-label-slug="fig-4"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9573/11218108/5557d4f6826d/13058_2024_1859_Fig4_HTML.jpg" itemprop="contentUrl" aria-describedby="figure-caption-3" role="button" data-image-width="744" data-image-height="1241" data-image-alt="Fig. 4" data-pmc-id="PMC11218108" data-figure-id="Fig4"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-3" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9573/11218108/7130fab4a64a/13058_2024_1859_Fig4_HTML.gif" alt="Fig. 4" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="744"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="1241"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Fig. 4 </p> </strong> <div class="figure-caption-contents"><p> Assessment of HER3 in patients… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Fig. 4 </p> </strong> <div class="figure-caption-contents"><p> Assessment of HER3 in patients from the GSE122630 study pre and post neoadjuvant… </p></div> </div> <figcaption id="figure-caption-3" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Fig. 4 </strong> <div class="figure-caption-contents">Assessment of HER3 in patients from the GSE122630 study pre and post neoadjuvant therapy. <b>A</b> HER3 expression at baseline (T1), at two weeks during neoadjuvant therapy (T2), mid-neoadjuvant therapy (T3) and at surgical resection (T4) <b>B</b> HER3 expression per patient at all timepoints where a biopsy was available with insets showing an example of a patient with HER3 decrease and a patient with HER3 increase <b>C</b> Microenvironmental cell populations in patients with HER3 decrease and patients with HER3 increase at T4 (surgical resection)</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="4" data-label-slug="fig-5"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9573/11218108/dd889c538413/13058_2024_1859_Fig5_HTML.jpg" itemprop="contentUrl" aria-describedby="figure-caption-4" role="button" data-image-width="792" data-image-height="1240" data-image-alt="Fig. 5" data-pmc-id="PMC11218108" data-figure-id="Fig5"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-4" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9573/11218108/ea80a8a589f1/13058_2024_1859_Fig5_HTML.gif" alt="Fig. 5" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="792"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="1240"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Fig. 5 </p> </strong> <div class="figure-caption-contents"><p> Differential biologies in patients with… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Fig. 5 </p> </strong> <div class="figure-caption-contents"><p> Differential biologies in patients with HER3 increase post neoadjuvant therapy. <b> A </b> Differential gene… </p></div> </div> <figcaption id="figure-caption-4" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Fig. 5 </strong> <div class="figure-caption-contents">Differential biologies in patients with HER3 increase post neoadjuvant therapy. <b>A</b> Differential gene expression in patients with HER3 decrease or HER3 increase at T4 (surgical resection). <b>B</b> Top 20 most upregulated and downregulated genesets in patients that showed a HER3 increase or decrease post neoadjuvant therapy. <b>C</b> Enrichment plots showing upregulation and downregulation of immune response in patients with HER3 decrease or HER3 increase post neoadjuvant therapy. <b>D</b> String network formed by the top 11 most upregulated genes in patients that showed a HER3 decrease post-neoadjuvant therapy</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="5" data-label-slug="fig-6"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9573/11218108/29b216b7294b/13058_2024_1859_Fig6_HTML.jpg" itemprop="contentUrl" aria-describedby="figure-caption-5" role="button" data-image-width="740" data-image-height="1241" data-image-alt="Fig. 6" data-pmc-id="PMC11218108" data-figure-id="Fig6"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-5" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9573/11218108/16c61c4ac6b2/13058_2024_1859_Fig6_HTML.gif" alt="Fig. 6" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="740"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="1241"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Fig. 6 </p> </strong> <div class="figure-caption-contents"><b> A </b> Heatmap of the hallmark…</div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Fig. 6 </p> </strong> <div class="figure-caption-contents"><b> A </b> Heatmap of the hallmark gene sets between patients with decreased or increased…</div> </div> <figcaption id="figure-caption-5" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Fig. 6 </strong> <div class="figure-caption-contents"><b>A</b> Heatmap of the hallmark gene sets between patients with decreased or increased HER3 expression at T1 and T4 (n = 25) with red inset depicting the statistically significant hallmarks and <b>B</b> Boxplots showing comparison between patients with an increase or a decrease in HER3 post NAT in a select number of significantly differential pathways from the Hallmarks gene sets as analyzed using Kruskal–Wallis test. <i>T</i>-test between groups were carried out and <i>P</i>-values < 0.05 were considered statistically significant</div> </figcaption> </figure> <figure class="figure-item tail" itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="6" data-label-slug="fig-7"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9573/11218108/454900b7bd43/13058_2024_1859_Fig7_HTML.jpg" itemprop="contentUrl" aria-describedby="figure-caption-6" role="button" data-image-width="784" data-image-height="589" data-image-alt="Fig. 7" data-pmc-id="PMC11218108" data-figure-id="Fig7"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-6" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9573/11218108/1905fc5fd37a/13058_2024_1859_Fig7_HTML.gif" alt="Fig. 7" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="784"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="589"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Fig. 7 </p> </strong> <div class="figure-caption-contents"><p> Schematic of study pipeline (left)… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Fig. 7 </p> </strong> <div class="figure-caption-contents"><p> Schematic of study pipeline (left) and proposed diagnostic and therapeutic approaches for breast… </p></div> </div> <figcaption id="figure-caption-6" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Fig. 7 </strong> <div class="figure-caption-contents">Schematic of study pipeline (left) and proposed diagnostic and therapeutic approaches for breast cancer (right)</div> </figcaption> </figure> </div> <div class="see-all actions-bar"> <button class="show-more" 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Epub 2024 Oct 2.</span> <span class="docsum-journal-citation short-journal-citation">Life Sci. 2024.</span> <span class="citation-part">PMID: <span class="docsum-pmid">39366553</span></span> <span class="publication-type spaced-citation-item citation-part">Review.</span> </div> </div> </li> </ul> <div class="actions-bar"> <a class="show-all-linked-articles" data-href="/?linkname=pubmed_pubmed&from_uid=38951909" data-ga-category="similar_article" data-ga-action="show_all" > See all similar articles </a> </div> </div> <div class="references" id="references"> <h2 class="title"> References </h2> <div id='top-references-list' class="references-lists-container"> <div class="refs-list"> <ol id="top-references-list-1" class="references-list"> <li> <ol class="references-and-notes-list"> <li class="skip-numbering" value="1"> Schneider AP, 2nd, Zainer CM, Kubat CK, Mullen NK, Windisch AK. The breast cancer epidemic: 10 facts. 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data-ga-label="Breast Neoplasms* / therapy"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Breast+Neoplasms" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Breast Neoplasms* / therapy"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Breast Neoplasms/therapy"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Breast Neoplasms/therapy"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Female" tabindex="0" aria-controls="keyword-actions-mesh-terms-9" aria-expanded="false" data-pinger-ignore> Female </button><div id="keyword-actions-mesh-terms-9" 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data-ga-label=""Female"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Gene Expression Regulation, Neoplastic" tabindex="0" aria-controls="keyword-actions-mesh-terms-10" aria-expanded="false" data-pinger-ignore> Gene Expression Regulation, Neoplastic </button><div id="keyword-actions-mesh-terms-10" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Gene Expression Regulation, Neoplastic"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Gene+Expression+Regulation%2C+Neoplastic%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Gene+Expression+Regulation%2C+Neoplastic%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Gene Expression Regulation, Neoplastic"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Gene Expression Regulation, Neoplastic"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Gene+Expression+Regulation%2C+Neoplastic" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Gene Expression Regulation, Neoplastic"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Gene Expression Regulation, Neoplastic"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Gene Expression Regulation, Neoplastic"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Humans" tabindex="0" aria-controls="keyword-actions-mesh-terms-11" aria-expanded="false" data-pinger-ignore> Humans </button><div id="keyword-actions-mesh-terms-11" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Humans"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Humans"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Humans"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Humans" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Humans"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Humans"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Humans"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Middle Aged" tabindex="0" aria-controls="keyword-actions-mesh-terms-12" aria-expanded="false" data-pinger-ignore> Middle Aged </button><div id="keyword-actions-mesh-terms-12" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Middle Aged"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Middle+Aged%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Middle+Aged%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Middle Aged"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Middle Aged"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Middle+Aged" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Middle Aged"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Middle Aged"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Middle Aged"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Neoadjuvant Therapy* / methods" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-13" aria-expanded="false" data-pinger-ignore> Neoadjuvant Therapy* / methods </button><div id="keyword-actions-mesh-terms-major-13" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Neoadjuvant Therapy* / methods"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Neoadjuvant+Therapy%2Fmethods%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Neoadjuvant+Therapy%2Fmethods%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Neoadjuvant Therapy/methods"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Neoadjuvant Therapy* / methods"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Neoadjuvant+Therapy" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Neoadjuvant Therapy* / methods"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Neoadjuvant Therapy/methods"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Neoadjuvant Therapy/methods"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Positron-Emission Tomography / methods" tabindex="0" aria-controls="keyword-actions-mesh-terms-14" aria-expanded="false" data-pinger-ignore> Positron-Emission Tomography / methods </button><div id="keyword-actions-mesh-terms-14" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Positron-Emission Tomography / methods"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Positron-Emission+Tomography%2Fmethods%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Positron-Emission+Tomography%2Fmethods%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Positron-Emission Tomography/methods"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Positron-Emission Tomography / methods"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Positron-Emission+Tomography" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Positron-Emission Tomography / methods"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Positron-Emission Tomography/methods"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Positron-Emission Tomography/methods"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Prospective Studies" tabindex="0" aria-controls="keyword-actions-mesh-terms-15" aria-expanded="false" data-pinger-ignore> Prospective Studies </button><div id="keyword-actions-mesh-terms-15" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Prospective Studies"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Prospective+Studies%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Prospective+Studies%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Prospective Studies"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Prospective Studies"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Prospective+Studies" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Prospective Studies"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Prospective Studies"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Prospective Studies"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Receptor, ErbB-2 / genetics" tabindex="0" aria-controls="keyword-actions-mesh-terms-16" aria-expanded="false" data-pinger-ignore> Receptor, ErbB-2 / genetics </button><div id="keyword-actions-mesh-terms-16" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Receptor, ErbB-2 / genetics"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Receptor%2C+ErbB-2%2Fgenetics%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Receptor%2C+ErbB-2%2Fgenetics%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Receptor, ErbB-2/genetics"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Receptor, ErbB-2 / genetics"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Receptor%2C+ErbB-2" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Receptor, ErbB-2 / genetics"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Receptor, ErbB-2/genetics"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Receptor, ErbB-2/genetics"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Receptor, ErbB-2 / metabolism" tabindex="0" aria-controls="keyword-actions-mesh-terms-17" aria-expanded="false" data-pinger-ignore> Receptor, ErbB-2 / metabolism </button><div id="keyword-actions-mesh-terms-17" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Receptor, ErbB-2 / metabolism"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Receptor%2C+ErbB-2%2Fmetabolism%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Receptor%2C+ErbB-2%2Fmetabolism%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Receptor, ErbB-2/metabolism"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Receptor, ErbB-2 / metabolism"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Receptor%2C+ErbB-2" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Receptor, ErbB-2 / metabolism"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Receptor, ErbB-2/metabolism"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Receptor, ErbB-2/metabolism"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Receptor, ErbB-3* / genetics" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-18" aria-expanded="false" data-pinger-ignore> Receptor, ErbB-3* / genetics </button><div id="keyword-actions-mesh-terms-major-18" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Receptor, ErbB-3* / genetics"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Receptor%2C+ErbB-3%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Receptor%2C+ErbB-3%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Receptor, ErbB-3/genetics"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Receptor, ErbB-3* / genetics"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Receptor%2C+ErbB-3" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Receptor, ErbB-3* / genetics"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Receptor, ErbB-3/genetics"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Receptor, ErbB-3/genetics"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Receptor, ErbB-3* / metabolism" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-19" aria-expanded="false" data-pinger-ignore> Receptor, ErbB-3* / metabolism </button><div id="keyword-actions-mesh-terms-major-19" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Receptor, ErbB-3* / metabolism"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Receptor%2C+ErbB-3%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Receptor%2C+ErbB-3%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Receptor, ErbB-3/metabolism"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Receptor, ErbB-3* / metabolism"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Receptor%2C+ErbB-3" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Receptor, ErbB-3* / metabolism"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Receptor, ErbB-3/metabolism"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Receptor, ErbB-3/metabolism"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Receptors, Estrogen / metabolism" tabindex="0" aria-controls="keyword-actions-mesh-terms-20" aria-expanded="false" data-pinger-ignore> Receptors, Estrogen / metabolism </button><div id="keyword-actions-mesh-terms-20" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Receptors, Estrogen / metabolism"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Receptors%2C+Estrogen%2Fmetabolism%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Receptors%2C+Estrogen%2Fmetabolism%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Receptors, Estrogen/metabolism"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Receptors, Estrogen / metabolism"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Receptors%2C+Estrogen" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Receptors, Estrogen / metabolism"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Receptors, Estrogen/metabolism"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Receptors, Estrogen/metabolism"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Signal Transduction" tabindex="0" aria-controls="keyword-actions-mesh-terms-21" aria-expanded="false" data-pinger-ignore> Signal Transduction </button><div id="keyword-actions-mesh-terms-21" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Signal Transduction"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Signal+Transduction%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Signal+Transduction%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Signal Transduction"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Signal Transduction"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Signal+Transduction" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Signal Transduction"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Signal Transduction"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Signal Transduction"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li></ul> </div> <div id="substances" class="substances keywords-section"> <h2 class="title"> Substances </h2> <ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Receptor, ErbB-3" tabindex="0" aria-controls="keyword-actions-substances-0" aria-expanded="false" data-pinger-ignore> Receptor, ErbB-3 </button><div id="keyword-actions-substances-0" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Receptor, ErbB-3"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Receptor%2C+ErbB-3%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Receptor%2C+ErbB-3%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Receptor, ErbB-3"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Receptor, ErbB-3"> 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