CINXE.COM

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id="page-title">Innovation Ventures Philanthropy Fund (InVent Fund)</h1> <div class="content-top"> </div> <div id="main-wrapper"> <div id="main" class="clearfix"> <div id="content" class="column"> <div class="inside"> <a id="main-content"></a> <div class="tabs"></div> <div class="region region-content"> <div id="block-system-main" class="block block-system"> <div class="content"> <div class="view view-taxonomy-term-new view-id-taxonomy_term_new view-display-id-page view-dom-id-e054c4315e985d27cc319ae6589910db"> <div class="attachment attachment-before"> <div class="view view-taxonomy-term-new view-id-taxonomy_term_new view-display-id-attachment_5"> </div><div class="view view-taxonomy-term-new view-id-taxonomy_term_new view-display-id-attachment_6"> </div> </div> <div class="view-content"> <div> <div> <div><div class="content"> <div class="field field-name-field-body field-type-text-long field-label-hidden"> <figure class="image"><img alt="UCSF Lab Samples" height="495" src="/sites/venture.ucsf.edu/files/wysiwyg/InVent%20Fund.jpg" width="2624" /> <figcaption>Alex Marson's Lab, UCSF 2018</figcaption> </figure> <h4>UCSF Thrives on Bold Ideas!</h4> <p>The Innovation Ventures Philanthropic Fund was established by Barry Selick, PhD, formerly Vice Chancellor for Business Development, Innovation, and Partnerships, and is now being led by Roopa Ramamoorthi, PhD, Director, Catalyst and InVent Fund, and Program Director Sohela Shah, PhD.</p> <div class="wysiwyg_twocols layout--50-50"> <div class="wysiwyg_twocols--first bg--transparent"> <figure class="image" style="float:left"><img alt="Roopa Ramamoorthi, PhD" height="205" src="/sites/venture.ucsf.edu/files/wysiwyg/Roopa%20Ramamoorthi.png" width="205" /> <figcaption>Roopa Ramamoorthi, PhD</figcaption> </figure> </div> <div class="wysiwyg_twocols--second bg--transparent"> <figure class="image" style="float:left"><img alt="" height="200" src="/sites/venture.ucsf.edu/files/wysiwyg/Sohela%20Shah.png" width="200" /> <figcaption>Sohela Shah, PhD.</figcaption> </figure> </div> </div> <p> </p> <p>With the UCSF Innovation Ventures InVent Fund, a philanthropic trust to boost the University’s most promising healthcare discoveries, we now have the power to invest in ourselves. UCSF seeks to rewrite the rules on how breakthrough discoveries are developed at our university. Instead of prematurely licensing the rights to our most promising but early findings to the industry, we have created a fund to provide financial support, as well as experienced product development mentoring and expertise to a small number of outstanding projects. By supporting and de-risking our most promising projects through translational development, we expect to capture greater value for UCSF and our inventors with the added benefit of building a sustainable program of funding for future innovations.</p> <p><a href="https://innovation.ucsf.edu/silicon-valley-supports-ucsf%E2%80%99s-innovation">Find out how Silicon Valley philanthropists are supporting the University's science</a>.</p> <p><strong>Podcasts</strong></p> <div class="wysiwyg_twocols layout--50-50"> <div class="wysiwyg_twocols--first bg--transparent"> <p><a href="http://innovation.ucsf.edu/shokat-jura-discuss-invent-fund"><img alt="" height="1250" src="/sites/venture.ucsf.edu/files/wysiwyg/Shokat%20%26%20Jura%20Podcast%20Image%202.jpg" width="1756" /></a></p> </div> <div class="wysiwyg_twocols--second bg--transparent"> <p><a href="http://soundcloud.com/user-176501713/arun-wiita-interview-for-invent-fund?si=d616b3ef892f43ad9e18a7861b3fe7d1&utm_source=clipboard&utm_medium=text&utm_campaign=social_sharing"><img alt="" height="1250" src="/sites/venture.ucsf.edu/files/wysiwyg/Arun%20Wiita%20Podcast%20Image%202_0.jpg" width="1756" /></a></p> </div> </div> <p><b>Successful Exits</b></p> <ul> <li style="margin: 0in;"><span style="font-size:12pt"><span style="font-family:"Helvetica Neue Light""><span style="font-family:"Helvetica Neue""><strong>Stephen Nishimura, MD, Jim Marks, MD and Yifan Cheng, PhD</strong>: </span></span></span><span style="font-size:12pt"><span style="font-family:"Helvetica Neue Light""><span style="font-family:"Helvetica Neue"">Antibody targeting integrin alphavbeta8 to inhibit TGF beta activation, licensed to Corbus. <a href="https://www.corbuspharma.com/press-releases/detail/360/corbus-pharmaceuticals-licenses-two-integrin-targeting-mabs">LINK</a>.</span></span></span></li> <li style="margin: 0in;"><span style="font-size:12pt"><span style="font-family:"Helvetica Neue Light""><span style="font-family:"Helvetica Neue""><strong>Natalia Jura, PhD and Kevan Shokat, PhD,</strong> Novel class of HER3 inhibitors, part of the UCSF spin-out company Rezo. Listen to the <a href="https://soundcloud.com/user-176501713/kevan-shokat-natalia-jura-on-the-invent-fund?si=a66ae11427ce4e11930d10982de632ca&utm_source=clipboard&utm_medium=text&utm_campaign=social_sharing">Podcast</a>.</span></span></span></li> <li style="margin: 0in;"><strong>Shant Vartanian, MD</strong>, Percutaneous arteriovenous fistula for hemodialysis access, licensed to Venova Medical, Inc.</li> <li style="margin: 0in;"><span style="font-size:12pt"><span style="font-family:"Helvetica Neue Light""><span style="font-family:"Helvetica Neue""><strong>Bryan King, MD, MBA, and Michael Godoy</strong>, GritX, a digital application for mental health and wellness. <a href="https://www.prweb.com/releases/2023/07/prweb19438928.htm">Read the press release</a>.</span></span></span></li> </ul> <p><b>Current Portfolio</b></p> <p>Some of the current healthcare technologies in development are:</p> <h4 style="text-align: center;">2020 Awarded Projects</h4> <div class="wysiwyg_twocols layout--50-50"> <div class="wysiwyg_twocols--first bg--interactive-blue"> <p><span style="font-size:12pt"><span style="font-family:"Helvetica Neue Light""><span style="font-family:"Helvetica Neue""><strong>Jennifer Chen, MD, Bill DeGrado, PhD</strong>, A novel compound inhibitor to treat fibrotic diseases and potentially cancer. </span></span></span></p> <ul> <li style="margin-left: 40px;"><span style="font-size:12pt"><span style="font-family:"Helvetica Neue Light""><span style="font-family:"Helvetica Neue"">Harrigton Discovery Institute Scholar Innovator Award to Jennifer Chen </span></span></span></li> <li style="margin-left: 40px;"><span style="font-size:12pt"><span style="font-family:"Helvetica Neue Light""><span style="font-family:"Helvetica Neue"">Publication: Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice, Science Transl Med, 2020. </span></span></span><span style="font-size:12pt"><span style="font-family:"Helvetica Neue Light""><span style="font-family:"Helvetica Neue""><a href="https://pubmed.ncbi.nlm.nih.gov/32817366/">LINK</a></span></span></span></li> </ul> </div> <div class="wysiwyg_twocols--second bg--interactive-teal"> <p><span style="font-size:12pt"><span style="font-family:"Helvetica Neue Light""><span style="font-family:"Helvetica Neue""><strong>Jason Gestwicki, PhD,</strong> Development of novel inhibitors against a validated cancer target</span></span></span>.</p> <ul> <li style="margin-left: 40px;"><span style="font-size:12.0pt"><span style="font-family:"Helvetica Neue"">Publication: A phosphoramidate strategy enables membrane permeability of a non nucleotide inhibitor of prolyl isomerase Pin1, ACS Med. Chem Lett, 2020, <a href="https://pubmed.ncbi.nlm.nih.gov/32944137/">LINK</a></span></span></li> </ul> </div> </div> <div class="wysiwyg_twocols layout--50-50"> <div class="wysiwyg_twocols--first bg--interactive-teal"> <p style="margin:0in"><span style="font-size:12pt"><span style="tab-stops:list .5in"><span style="font-family:"Helvetica Neue Light""><span style="font-family:"Helvetica Neue""><strong>Arun Wiita, MD, PhD</strong>, Immunotherapy targeting cell surface markers for the treatment of B-cell malignancies</span></span></span></span>.</p> <ul style="margin-left: 40px;"> <li style="margin: 0in;"><span style="font-size:12.0pt"><span style="font-family:"Helvetica Neue"">CIRM Award for $3.33M </span></span><a href="https://www.cirm.ca.gov/our-progress/people/arun-wiita">LINK</a></li> <li style="margin: 0in;"><span style="font-size:12.0pt"><span style="font-family:"Helvetica Neue"">Publication: CD72 nanobody based CAR-T cells have potent anti tumor efficacy in B cell malignancies, Blood, 2021. <a href="https://ashpublications.org/blood/article/138/Supplement%201/1717/480840/CD72-Nanobody-Based-CAR-T-Cells-Have-Potent-Anti">LINK</a></span></span></li> </ul> <p> </p> </div> <div class="wysiwyg_twocols--second bg--interactive-blue"> <p style="margin:0in"><span style="font-size:12pt"><span style="tab-stops:list .5in"><span style="font-family:"Helvetica Neue Light""><span style="font-family:"Helvetica Neue""><strong>Alan Verkman, MD, PhD, Onur Cil, MD, PhD,</strong> Small molecule inhibitors for treatment of hyperoxaluria and constipation.</span></span></span></span></p> <ul style="margin-left: 40px;"> <li style="margin: 0in;"><span style="font-size:12pt"><span style="font-family:"Helvetica Neue"">NIH RO1 award to Onur Cil, with total funding of $1.61M</span></span>. <a href="https://reporter.nih.gov/search/DrV6IrGr-Ea1vIYO_gyeog/project-details/10440399">LINK</a></li> <li style="margin: 0in;"><span style="font-size:12.0pt"><span style="font-family:"Helvetica Neue"">Publication: Small molecule inhibitor of intestinal anion exchanger SLC26A3 for therapy of hyperoxaluria and nephrolithiasis, JCI Insight, 2022. <a href="https://pubmed.ncbi.nlm.nih.gov/35608921/">LINK</a></span></span></li> <li style="margin: 0in;">Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action, European J. of Med Chem, 2023. <a href="https://www.sciencedirect.com/science/article/pii/S0223523423000648">LINK</a></li> </ul> </div> </div> <div class="wysiwyg_twocols layout--50-50"> <div class="wysiwyg_twocols--first bg--interactive-blue"> <p><span style="font-size:12pt"><span style="tab-stops:list .5in"><span style="font-family:"Helvetica Neue Light""><span style="font-family:"Helvetica Neue""><strong>Flavio Vincenti, MD</strong>, Charly Craik, PhD, Novel enzyme technology for prevention of kidney transplant rejection.</span></span></span></span></p> </div> <div class="wysiwyg_twocols--second bg--interactive-teal"> <p><span style="font-size:12pt"><span style="tab-stops:list .5in"><span style="font-family:"Helvetica Neue Light""><span style="font-family:"Helvetica Neue""><strong>Charly Craik, PhD and Kevan Shokat PhD,</strong> Platform technology to target KRAS mutant cancers using recombinant antibodies.</span></span></span></span></p> <ul> <li>Publication: A covalent inhibitor of K-RAS (G12C) induces MHC class I presentation of haptenated peptide neoepitopes targetable by immunotherapy, Cancer Cell, 2022. <span style="font-size:12pt"><span style="tab-stops:list .5in"><span style="font-family:"Helvetica Neue Light""><span style="font-family:"Helvetica Neue""> </span></span></span></span><a href="https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00318-X">LINK</a></li> </ul> </div> </div> <p> </p> <h4 style="margin: 0in; text-align: center;">2021 Awarded Projects</h4> <div class="wysiwyg_twocols layout--50-50"> <div class="wysiwyg_twocols--first bg--interactive-teal"> <p style="margin:0in"><span style="font-size:12pt"><span style="tab-stops:list .5in"><span style="font-family:"Helvetica Neue Light""><span style="font-family:"Helvetica Neue""><strong>Adam Renslo, PhD and Charly Craik, PhD</strong>, Small molecule inhibitors for treating cytomegalovirus and HSV.</span></span></span></span></p> <ul style="margin-left: 40px;"> <li style="margin: 0in;"><span style="font-size:12pt"><span style="font-family:"Helvetica Neue"">Publication: Inhibiting a dynamic viral protease by targeting a non-catalytic cysteine, Chem. Cell. Biol., 2022. <a href="https://pubmed.ncbi.nlm.nih.gov/35364007/">LINK</a></span></span></li> </ul> <p> </p> </div> <div class="wysiwyg_twocols--second bg--interactive-blue"> <p style="margin:0in"><span style="font-size:12pt"><span style="tab-stops:list .5in"><span style="font-family:"Helvetica Neue Light""><span style="font-family:"Helvetica Neue""><strong>John Chorba, MD, and Kevan Shokat, PhD</strong>, Inhibiting PCSK9 to treat atherosclerosis.</span></span></span></span></p> <ul> <li style="margin: 0in 0in 0in 40px;"><span style="font-size:12pt"><span style="font-family:"Helvetica Neue Light""><span style="font-family:"Helvetica Neue"">Harrington Discovery Institute Scholar Innovator Award to John Chorba</span></span></span>.</li> <li style="margin: 0in 0in 0in 40px;"><span style="font-size:12.0pt"><span style="font-family:"Helvetica Neue"">NIH RO1 award to John Chorba with total funding of $1.81M. <a href="https://reporter.nih.gov/search/wnheE18iqUa2fPO1xUEhnA/project-details/10370428">LINK</a></span></span></li> </ul> <p> </p> </div> </div> <div class="wysiwyg_twocols layout--50-50"> <div class="wysiwyg_twocols--first bg--interactive-blue"> <p><span style="font-size:12pt"><span style="tab-stops:list .5in"><span style="font-family:"Helvetica Neue Light""><span style="font-family:"Helvetica Neue""><strong>Jack Taunton, PhD, Davide Ruggero, PhD,</strong> Preclinical development of a compound targeting a select pathway for treatment of myc driven cancers.</span></span></span></span></p> <ul> <li><span style="font-size:12pt"><span style="font-family:"Helvetica Neue"">Publication:</span></span> mRNA decoding in human is kinetically and structurally distinct from bacteria, Nature, 2023, <a href="https://pubmed.ncbi.nlm.nih.gov/37020024/">LINK</a></li> <li><span style="font-size:12pt"><span style="font-family:"Helvetica Neue"">Publication:</span></span> Synthesis and single molecule imaging reveal stereospecific enhancement of binding kinetics by the antitumor eEF1A antagonist SRA-3, Nat. Chem, 2022, <a href="https://pubmed.ncbi.nlm.nih.gov/36123449/">LINK</a></li> </ul> </div> <div class="wysiwyg_twocols--second bg--interactive-teal"> <p><span style="font-size:12pt"><span style="tab-stops:list .5in"><span style="font-family:"Helvetica Neue Light""><span style="font-family:"Helvetica Neue""><strong>Aparna Sundaram, MD and Bill DeGrado, PhD,</strong> Select Integrin inhibitor to mitigate exaggerated smooth muscle contraction in asthma</span></span></span></span>.</p> </div> </div> <div class="wysiwyg_twocols layout--50-50"> <div class="wysiwyg_twocols--first bg--interactive-teal"> <p><span style="font-size:12pt"><span style="tab-stops:list .5in"><span style="font-family:"Helvetica Neue Light""><span style="font-family:"Helvetica Neue""><strong>Pamela England, PhD and Matthew Jacobson, PhD,</strong> In vivo proof of concept of Nurr1 agonists in Parkinson’s Disease.</span></span></span></span></p> </div> <div class="wysiwyg_twocols--second bg--interactive-blue"> <p style="margin-left:48.0pt; margin:0in"><span style="font-size:12pt"><span style="font-family:"Helvetica Neue Light""><span style="font-family:"Helvetica Neue""><strong>Dean Sheppard, MD and Bin Liu, PhD</strong>, Humanized potent monoclonal antibodies against murine and human target integrin for cancer immunotherapy and prevention of corneal scarring after cataract surgery</span></span></span>.</p> <ul> <li style="margin: 0in 0in 0in 40px;"><span style="font-size:12pt"><span style="font-family:"Helvetica Neue Light""><span style="font-family:"Helvetica Neue"">Publication:</span></span></span><strong><span style="font-size:12pt"><span style="font-family:"Helvetica Neue Light""><span style="font-family:"Helvetica Neue""> </span></span></span></strong><span style="font-size:12pt"><span style="font-family:"Helvetica Neue Light""><span style="font-family:"Helvetica Neue"">Alphavbeta8 integrin targeting to prevent posterior capsular opacification, JCI Insight, 2021. <a href="https://pubmed.ncbi.nlm.nih.gov/34554928/">LINK</a> </span></span></span></li> <li style="margin: 0in 0in 0in 40px;"><span style="font-size:12pt"><span style="font-family:"Helvetica Neue Light""><span style="font-family:"Helvetica Neue"">Publication:</span></span></span> <span style="font-size:12pt"><span style="font-family:"Helvetica Neue Light""><span style="font-family:"Helvetica Neue"">Integrin alphavbeta8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy, Cell Rep. 2021. <a href="https://pubmed.ncbi.nlm.nih.gov/34233193/">LINK</a> </span></span></span></li> </ul> </div> </div> <h5 style="text-align: center;"> </h5> <h4 style="text-align: center;">2022 Awarded Projects</h4> <div class="wysiwyg_twocols layout--50-50"> <div class="wysiwyg_twocols--first bg--interactive-blue"> <p><span style="font-size:12pt"><span style="font-family:"Helvetica Neue Light""><span style="font-family:"Helvetica Neue""><strong>Nadav Ahituv, PhD,</strong> Leveraging sequences missing from the human genome for early diagnosis of cancers.</span></span></span></p> </div> <div class="wysiwyg_twocols--second bg--interactive-teal"> <p><span style="font-size:12pt"><span style="font-family:"Helvetica Neue Light""><span style="font-family:"Helvetica Neue""><strong>Bin Liu, PhD,</strong> A novel antibody for bone regeneration</span></span></span>.</p> </div> </div> <p> </p> <p> </p> <p> <a class="btn--small btn--more--reverse" href="https://innovation.ucsf.edu/invent-fund-application" style="font-family: inherit;">MORE ABOUT INVENT FUND</a> </p> <p><b>Make a Gift</b></p> <p>To join our visionary donors in supporting the growth of the fund and helping UCSF realize its mission, please contact Brandon (Bo) O’Hare, Senior Director Development at 773-354-1471 or <a data-auth="NotApplicable" data-linkindex="0" href="/cdn-cgi/l/email-protection#1c7e6e7d727873723273747d6e795c697f6f7a32797869" rel="noopener noreferrer" 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