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</a></div></div> <div class="slideshow-controls"> <div class="slideshow-controls__arrows"></div> </div> <span class="product-label-list"><script id="variant-label-8031108923560-45609276342440" type="text/template"></script><div class="product-label-container"></div></span> </div> <div class="title-row" > <h1 class="title">Genotoxicity, MNT</h1> </div> <div class="" > <div class="product-description rte cf"><span data-mce-fragment="1">The test compound is investigated for its ability to cause chromosomal aberrations or breakages by the in vitro micronucleus test MNT utilizing flow cytometry as a detection method. </span><br data-mce-fragment="1"></div> </div> <div class="product-detail-accordion not-in-quickbuy" > <div class="cc-accordion" data-allow-multi-open="true"> <details class="cc-accordion-item is-open" open> <summary class="cc-accordion-item__title"><div class="with-icon"> <span class="material-symbols-outlined"> check </span> <span class="with-icon__beside">Protocol</span> </div></summary> <div class="cc-accordion-item__panel"> <div class="cc-accordion-item__content rte cf"><p>Test concentrations: 11</p><p>Time points: 4h/ +S9 exposure followed by 20h recovery time and 24h/ -S9 exposure</p><p>Replicates: 2</p><p>Positive controls</p><p>Flow cytometry analysis</p></div> </div> </details> </div> </div> <div class="product-detail-accordion not-in-quickbuy" > <div class="cc-accordion" data-allow-multi-open="true"> <details class="cc-accordion-item is-open" open> <summary class="cc-accordion-item__title"><div class="with-icon"> <span class="material-symbols-outlined"> check </span> <span class="with-icon__beside">Deliverables</span> </div></summary> <div class="cc-accordion-item__panel"> <div class="cc-accordion-item__content rte cf"><p><span class="metafield-multi_line_text_field">Micronuclei formation as fold induction over the vehicle control <br /> </span></p></div> </div> </details> </div> </div> <div class="product-detail-accordion not-in-quickbuy" > <div class="cc-accordion" data-allow-multi-open="true"> <details class="cc-accordion-item is-open" open> <summary class="cc-accordion-item__title"><div class="with-icon"> <span class="material-symbols-outlined"> check </span> <span class="with-icon__beside">Reporting</span> </div></summary> <div class="cc-accordion-item__panel"> <div class="cc-accordion-item__content rte cf"><p><span class="metafield-multi_line_text_field">Excel or Full Word/PDF report<br /> </span></p></div> </div> </details> </div> </div> <div class="product-detail-accordion not-in-quickbuy" > <div class="cc-accordion" data-allow-multi-open="true"> <details class="cc-accordion-item"> <summary class="cc-accordion-item__title">Background</summary> <div class="cc-accordion-item__panel"> <div class="cc-accordion-item__content rte cf"><p>AMES test is used to identify compounds that can cause spontaneous point mutations such as base pair substitutions, deletions or duplications. These events can ultimately lead to cancer susceptibility. MNT assay is used to detect drug candidates causing chromosomal aberrations (aneugen) or breakages (clastogen) leading to perturbations in cell division. The resulting micronuclei adjacent to main nuclei are also a sign of genotoxicity.</p></div> </div> </details> </div> </div> </div> </div> <div class="detail product-column-right" data-cc-animate data-cc-animate-delay="0.2s"> <div class="product-form" data-ajax-add-to-cart="true" data-product-id="8031108923560" data-enable-history-state="true"> <div class="buy-buttons-row" > <form method="post" action="/cart/add" id="product-form-template--16460963283112__main-8031108923560" accept-charset="UTF-8" class="form product-purchase-form" enctype="multipart/form-data" data-product-id="8031108923560"><input type="hidden" name="form_type" value="product" /><input type="hidden" name="utf8" value="✓" /> <select name="id" class="original-selector hidden" aria-label="Options"> <option value="45609276342440" selected="selected" data-stock="">Default Title</option> </select> <div class="quantity-submit-row input-row "> <div class="quantity-submit-row__submit input-row"><button class="button button--large" type="submit" data-add-to-cart-text="Add to quote request">Add to quote request</button> </div> </div> <input type="hidden" name="product-id" value="8031108923560" /><input type="hidden" name="section-id" value="template--16460963283112__main" /></form> </div> <div class="lightish-spaced-row-above only-in-quickbuy"> <a class="more" href="/products/genotoxicity-mnt"> <span class="beside-svg underline">More details</span> <span class="icon--small icon-natcol ltr-icon"> <span class="material-symbols-outlined"> chevron_right </span></span> </a> </div> </div> <script type="application/json" id="ProductJson-8031108923560">{"id":8031108923560,"title":"Genotoxicity, MNT","handle":"genotoxicity-mnt","description":"\u003cspan data-mce-fragment=\"1\"\u003eThe test compound is investigated for its ability to cause chromosomal aberrations or breakages by the in vitro micronucleus test MNT utilizing flow cytometry as a detection method. \u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e","published_at":"2023-11-07T12:55:58+02:00","created_at":"2023-11-07T12:55:58+02:00","vendor":"Admescope","type":"","tags":[],"price":0,"price_min":0,"price_max":0,"available":true,"price_varies":false,"compare_at_price":null,"compare_at_price_min":0,"compare_at_price_max":0,"compare_at_price_varies":false,"variants":[{"id":45609276342440,"title":"Default Title","option1":"Default Title","option2":null,"option3":null,"sku":"","requires_shipping":false,"taxable":true,"featured_image":null,"available":true,"name":"Genotoxicity, MNT","public_title":null,"options":["Default Title"],"price":0,"weight":0,"compare_at_price":null,"inventory_management":null,"barcode":"","requires_selling_plan":false,"selling_plan_allocations":[]}],"images":["\/\/admeshop.com\/cdn\/shop\/files\/InvitroToxicologyNEG_7bca8eb4-735c-45e0-aab5-6edd991d40c4.png?v=1702464518"],"featured_image":"\/\/admeshop.com\/cdn\/shop\/files\/InvitroToxicologyNEG_7bca8eb4-735c-45e0-aab5-6edd991d40c4.png?v=1702464518","options":["Title"],"media":[{"alt":null,"id":29795162161320,"position":1,"preview_image":{"aspect_ratio":1.0,"height":1299,"width":1299,"src":"\/\/admeshop.com\/cdn\/shop\/files\/InvitroToxicologyNEG_7bca8eb4-735c-45e0-aab5-6edd991d40c4.png?v=1702464518"},"aspect_ratio":1.0,"height":1299,"media_type":"image","src":"\/\/admeshop.com\/cdn\/shop\/files\/InvitroToxicologyNEG_7bca8eb4-735c-45e0-aab5-6edd991d40c4.png?v=1702464518","width":1299}],"requires_selling_plan":false,"selling_plan_groups":[],"content":"\u003cspan data-mce-fragment=\"1\"\u003eThe test compound is investigated for its ability to cause chromosomal aberrations or breakages by the in vitro micronucleus test MNT utilizing flow cytometry as a detection method. \u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e"}</script> </div> </div> </div> <script type="application/ld+json"> { "@context": "http://schema.org/", "@type": "Product", "name": "Genotoxicity, MNT", "url": "https:\/\/admeshop.com\/products\/genotoxicity-mnt","image": [ "https:\/\/admeshop.com\/cdn\/shop\/files\/InvitroToxicologyNEG_7bca8eb4-735c-45e0-aab5-6edd991d40c4_1299x.png?v=1702464518" ],"description": "The test compound is investigated for its ability to cause chromosomal aberrations or breakages by the in vitro micronucleus test MNT utilizing flow cytometry as a detection method. 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