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151.6C112.2 482.9 48.6 426.1 18.6 352H135.3zm358.1 0c-30 74.1-93.6 130.9-171.9 151.6c25.5-34.2 45.2-87.7 55.3-151.6H493.4z"></path></svg><span>Global</span></button></div></header><main dir="ltr"><div class="css-1otjjom"><nav class="MuiTypography-root MuiTypography-body1 MuiBreadcrumbs-root css-y1im4h-MuiTypography-root-MuiBreadcrumbs-root" aria-label="breadcrumb"><ol class="MuiBreadcrumbs-ol css-4pdmu4-MuiBreadcrumbs-ol"><li class="MuiBreadcrumbs-li"><a color="inherit" class="css-14aisoc" data-discover="true" href="/fr" target="_self">Accueil</a></li><li aria-hidden="true" class="MuiBreadcrumbs-separator css-1wuw8dw-MuiBreadcrumbs-separator"><svg class="MuiSvgIcon-root MuiSvgIcon-fontSizeSmall css-ead8px-MuiSvgIcon-root" focusable="false" aria-hidden="true" viewBox="0 0 24 24" data-testid="NavigateNextIcon"><path d="M10 6 8.59 7.41 13.17 12l-4.58 4.59L10 18l6-6z"></path></svg></li><li class="MuiBreadcrumbs-li"><a color="inherit" class="css-14aisoc" data-discover="true" href="/fr/notre-science" target="_self">Notre science</a></li><li aria-hidden="true" class="MuiBreadcrumbs-separator css-1wuw8dw-MuiBreadcrumbs-separator"><svg class="MuiSvgIcon-root MuiSvgIcon-fontSizeSmall css-ead8px-MuiSvgIcon-root" focusable="false" aria-hidden="true" viewBox="0 0 24 24" data-testid="NavigateNextIcon"><path d="M10 6 8.59 7.41 13.17 12l-4.58 4.59L10 18l6-6z"></path></svg></li><li class="MuiBreadcrumbs-li"><span class="MuiTypography-root MuiTypography-body2 css-1boheuq-MuiTypography-root">Essais cliniques & résultats</span></li></ol></nav></div><div class="MuiStack-root css-j9j92j-MuiStack-root" id="top"><div class="dotcom-hero-banner MuiBox-root css-7vsjpe"><div class="MuiBox-root css-0"><div class="MuiBox-root css-0"><div class="MuiContainer-root MuiContainer-maxWidthDesktop css-10rfme0-MuiContainer-root"><div class="MuiGrid2-root MuiGrid2-container MuiGrid2-direction-xs-column css-1qgmfta-MuiGrid2-root"><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-desktop-12 MuiGrid2-grid-tablet-8 MuiGrid2-grid-mobile-4 css-689yzq-MuiGrid2-root"><h1 class="MuiTypography-root MuiTypography-h1 css-1hnspsh-MuiTypography-root">Essais cliniques & résultats</h1></div></div></div></div></div></div></div><div class="MuiContainer-root MuiContainer-maxWidthDesktop css-1f4kha5-MuiContainer-root"><div class="MuiStack-root css-u69w57-MuiStack-root" id="main"><div class="dotcom-content-block MuiBox-root css-gei8j6"><div class="MuiGrid2-root MuiGrid2-container MuiGrid2-direction-xs-row css-11gltm4-MuiGrid2-root" id="df51e37a-0a68-4ff2-8614-36e0a1b22b94"><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-mobile-4 MuiGrid2-grid-tablet-8 MuiGrid2-grid-desktop-12 css-epopls-MuiGrid2-root"><div class="css-l0ylpx"><img src="/optim/dotcom/pages/images/our-science/clinical-trials-and-results/herobanner-clinical-trials-results-06_20230811055916.jpg?size=xlarge" alt="" loading="lazy" class="css-1q02gsy"/></div><span class="MuiTypography-root MuiTypography-caption css-vllrlk-MuiTypography-root">De gauche à droite : Ingo, maladie de Pompe, Australie - Amit, asthme, Israël - Alfie, déficit en sphingomyélinase acide, Royaume-Uni - Danielle, myélome multiple, États-Unis - Ron, carcinome épidermoïde cutané, États-Unis - Hsieh, maladie de Fabry, Taïwan - Miwako, dermatite atopique, Japon - Jeff, asthme, Canada - Elizabeth, dermatite atopique, États-Unis - Dave, sclérose en plaques, Royaume-Uni - Cassie, sclérose en plaques, Australie - JJ, patient ASMD, États-Unis - Dov, sclérose en plaques, Israël - Jenny, sclérose en plaques thrombotique thrombotique acquise, Israël Dave, sclérose en plaques, Royaume-Uni - Cassie, sclérose en plaques, Australie - JJ, patient ASMD, États-Unis - Dov, sclérose en plaques, Israël - Jenny, purpura thrombocytopénique thrombotique acquis, États-Unis - Stephan, hémophilie, Kenya - Jodie, maladie de l'agglutinine froide, États-Unis - Brad, maladie de l'agglutinine froide, Canada - Schlomit, myélome multiple, Israël</span></div><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-mobile-4 MuiGrid2-grid-tablet-8 MuiGrid2-grid-desktop-12 css-epopls-MuiGrid2-root"><div class="MuiGrid2-root MuiGrid2-container MuiGrid2-direction-xs-row css-picray-MuiGrid2-root"><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-mobile-4 MuiGrid2-grid-tablet-8 MuiGrid2-grid-desktop-12 css-h663uz-MuiGrid2-root"><div class="MuiGrid2-root MuiGrid2-container MuiGrid2-direction-xs-row css-2tm260-MuiGrid2-root"><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-mobile-4 MuiGrid2-grid-tablet-8 MuiGrid2-grid-desktop-12 css-bhg4dc-MuiGrid2-root"><div><p class="MuiTypography-root MuiTypography-body1 css-1h3p22q-MuiTypography-root">Les essais cliniques permettent de déterminer si un nouveau moyen de prévenir ou de soigner une maladie peut être considéré comme sûr et efficace sur les humains. Cette étape essentielle à la création d’un nouveau médicament ou d’un vaccin intervient après de nombreuses années, parfois des décennies de recherche. Les personnes qui participent aux essais cliniques apportent une contribution inestimable car ils aident à faire progresser la science et la médecine, et à élaborer de nouveaux traitements pour la santé de tous.</p> <p class="MuiTypography-root MuiTypography-body1 css-sqijso-MuiTypography-root">Les patients sont au cœur de la démarche scientifique chez Sanofi. Nos équipes de recherche et développement travaillent auprès des patients pour comprendre pleinement leurs priorités, leurs expériences, leurs besoins et les défis auxquels ils font face. C’est en étant à l’écoute des patients et en traduisant leurs idées en actions, que ce soit au tout début du développement des essais cliniques ou au bien au-delà, que nos chercheurs peuvent élaborer de nouvelles solutions thérapeutiques qui présentent des résultats positifs, répondre aux besoins non satisfaits et améliorer la qualité de vie des patients.</p> </div></div></div></div></div></div></div></div><div class="dotcom-content-block MuiBox-root css-jqikz1"><div class="MuiGrid2-root MuiGrid2-container MuiGrid2-direction-xs-row-reverse css-2wefi0-MuiGrid2-root" id="aab79338-9ac0-4f40-9211-387a94527ed2"><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-mobile-4 MuiGrid2-grid-tablet-8 MuiGrid2-grid-desktop-7 css-1slqh4o-MuiGrid2-root"><div class="css-qwp8kn"><img src="/optim/dotcom/pages/images/our-science/clinical-trials-and-results/clinical-trials-and-results-swathi_20230810131700.jpg?size=large" alt="" loading="lazy" class="css-6ijlax"/></div><span class="MuiTypography-root MuiTypography-caption css-vllrlk-MuiTypography-root">Swathi, patiente atteinte de la maladie de la Pompe</span></div><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-mobile-4 MuiGrid2-grid-tablet-8 MuiGrid2-grid-desktop-5 css-nar7n6-MuiGrid2-root"><div class="MuiGrid2-root MuiGrid2-container MuiGrid2-direction-xs-row css-4bcpxk-MuiGrid2-root"><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-mobile-4 MuiGrid2-grid-tablet-8 MuiGrid2-grid-desktop-5 css-4lhy0n-MuiGrid2-root"><h2 class="MuiTypography-root MuiTypography-h2 css-1te8woh-MuiTypography-root">Qu’est-ce qu’un essai clinique ?</h2></div><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-mobile-4 MuiGrid2-grid-tablet-8 MuiGrid2-grid-desktop-5 css-4lhy0n-MuiGrid2-root"><div><p class="MuiTypography-root MuiTypography-body1 css-1h3p22q-MuiTypography-root">Avant d’être mis à la disposition des patients, les nouveaux traitements doivent tout d’abord être testés pour garantir leur efficacité et leur bonne tolérabilité. L’essai clinique – ou étude sur des humains – constitue ainsi une étape clé du processus d’approbation de potentiels traitements par les autorités sanitaires. Le traitement, ou « produit candidat », peut être un nouveau vaccin, un médicament, une combinaison de médicaments, voire même une nouvelle application d’un composé existant.</p> <p class="MuiTypography-root MuiTypography-body1 css-sqijso-MuiTypography-root"><strong>Un essai clinique doit permettre</strong> :</p> <ul class="MuiTypography-root MuiTypography-body1 css-sqijso-MuiTypography-root"> <li class="MuiTypography-root MuiTypography-body1 css-1ubkcfk-MuiTypography-root">de valider le nouveau médicament ou vaccin, ou</li> <li class="MuiTypography-root MuiTypography-body1 css-1ubkcfk-MuiTypography-root">de définir les populations de patients au sein desquelles le traitement potentiel peut être le plus efficace.</li> </ul> <p class="MuiTypography-root MuiTypography-body1 css-sqijso-MuiTypography-root">Dans le cadre de l’étude, l’effet du produit candidat est comparé soit à un placebo (une substance sans activité pharmacologique) soit à un traitement existant, afin d’évaluer son innocuité et son efficacité. Durant un essai clinique complet, les chercheurs visent à déterminer :</p> <ul class="MuiTypography-root MuiTypography-body1 css-sqijso-MuiTypography-root"> <li class="MuiTypography-root MuiTypography-body1 css-1ubkcfk-MuiTypography-root">la posologie la plus efficace,</li> <li class="MuiTypography-root MuiTypography-body1 css-1ubkcfk-MuiTypography-root">sa toxicité éventuelle, et la nature et la fréquence des effets indésirables qu’il peut entraîner.</li> </ul> </div></div></div></div></div></div><div class="dotcom-focused-block MuiBox-root css-jqikz1"><div class="MuiGrid2-root MuiGrid2-container MuiGrid2-direction-xs-row css-1ri9qdm-MuiGrid2-root" id="3d8a1183-36af-495f-ac61-0e9bbbdb64f6"><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-mobile-4 MuiGrid2-grid-tablet-8 MuiGrid2-grid-desktop-12 css-epopls-MuiGrid2-root"><h2 class="MuiTypography-root MuiTypography-h2 css-18fz9jt-MuiTypography-root">Vous souhaitez participer à un essai clinique chez Sanofi ?</h2></div><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-desktop-12 MuiGrid2-grid-tablet-8 MuiGrid2-grid-mobile-4 css-gx4bfz-MuiGrid2-root"><button class="elements-ds-twdzwl"><svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="arrow-up-right-from-square" class="svg-inline--fa fa-arrow-up-right-from-square elements-ds-9lhz6f" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 0c-17.7 0-32 14.3-32 32s14.3 32 32 32h82.7L201.4 265.4c-12.5 12.5-12.5 32.8 0 45.3s32.8 12.5 45.3 0L448 109.3V192c0 17.7 14.3 32 32 32s32-14.3 32-32V32c0-17.7-14.3-32-32-32H320zM80 32C35.8 32 0 67.8 0 112V432c0 44.2 35.8 80 80 80H400c44.2 0 80-35.8 80-80V320c0-17.7-14.3-32-32-32s-32 14.3-32 32V432c0 8.8-7.2 16-16 16H80c-8.8 0-16-7.2-16-16V112c0-8.8 7.2-16 16-16H192c17.7 0 32-14.3 32-32s-14.3-32-32-32H80z"></path></svg><a target="_blank" title="https://www.sanofistudies.com/global/en/" href="https://www.sanofistudies.com/global/en/">Découvrez comment participer</a></button></div></div></div><div class="dotcom-content-block MuiBox-root css-jqikz1"><div class="MuiGrid2-root MuiGrid2-container MuiGrid2-direction-xs-row css-cr2kt9-MuiGrid2-root" id="f02e8bc6-1c03-470d-9998-dceb7bf20645"><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-mobile-4 MuiGrid2-grid-tablet-8 MuiGrid2-grid-desktop-8 css-c8gmj9-MuiGrid2-root"><h2 class="MuiTypography-root MuiTypography-h2 css-1te8woh-MuiTypography-root">Dans quels cas une étude clinique est-elle lancée ?</h2></div><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-mobile-4 MuiGrid2-grid-tablet-8 MuiGrid2-grid-desktop-8 css-c8gmj9-MuiGrid2-root"><div><p class="MuiTypography-root MuiTypography-body1 css-1h3p22q-MuiTypography-root">Pour qu’un essai clinique puisse être lancé, des études de laboratoire doivent avoir fourni des résultats satisfaisants ou supérieurs aux exigences les plus rigoureuses, telles que fixées par les autorités réglementaires.</p> <ul class="MuiTypography-root MuiTypography-body1 css-sqijso-MuiTypography-root"> <li class="MuiTypography-root MuiTypography-body1 css-1ubkcfk-MuiTypography-root">Les études en laboratoire sont conçues pour évaluer des composés ou combinaisons de composés – spécifiques, et ce, de diverses manières. En effectuant des tests « in vitro » et des expérimentations animales, les scientifiques peuvent évaluer la tolérabilité de ces composés, et déterminer si ceux-ci présentent une valeur thérapeutique ou préventive potentielle. Si toutes les données produites sont satisfaisantes, l’étape suivante consiste à envisager des tests impliquant des volontaires sains ou des patients.</li> <li class="MuiTypography-root MuiTypography-body1 css-1ubkcfk-MuiTypography-root">À ce stade, le fabricant soumet une demande à un comité d’éthique indépendant (CEI) ou à un comité de protection des personnes (CPP). Ces organismes totalement indépendants examinent les procédures et les protocoles d’essai. Leur décision d’autoriser ou non l’essai clinique d’un composé se base sur la protection accordée aux participants et sur le besoin d’une nouvelle solution thérapeutique ou préventive. Pour en savoir plus sur la manière dont les activités médicales et de R&D de Sanofi sont menées : <a class="elements-ds-rtmnu6" href="https://www.sanofi.com/assets/dotcom/content-app/documents/Medical-Ethics-Bioethics-and-Clinical-Trials.pdf">fiche d'information sur l'éthique médicale et la bioéthique</a>.</li> <li class="MuiTypography-root MuiTypography-body1 css-1ubkcfk-MuiTypography-root">Un essai clinique ne peut être effectué que s’il a été approuvé par l’un de ces comités, celui-ci devant ensuite suivre le déroulement de l’essai afin d’assurer la continuité de la sécurité et du bien-être des participants.</li> </ul> </div></div></div></div><div class="dotcom-content-block MuiBox-root css-jqikz1"><div class="MuiGrid2-root MuiGrid2-container MuiGrid2-direction-xs-row css-1dgjf7h-MuiGrid2-root" id="cc10a980-5bb7-4e07-a95b-5d3d2a5c0131"><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-mobile-4 MuiGrid2-grid-tablet-8 MuiGrid2-grid-desktop-7 css-1slqh4o-MuiGrid2-root"><div class="css-17zee46"><img src="/optim/dotcom/pages/images/our-science/clinical-trials-and-results/clinical-trials-and-results-anita_20230810131743.jpg?size=large" alt="" loading="lazy" class="css-6ijlax"/></div><span class="MuiTypography-root MuiTypography-caption css-vllrlk-MuiTypography-root">Anita, sclérose en plaques, Norvège</span></div><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-mobile-4 MuiGrid2-grid-tablet-8 MuiGrid2-grid-desktop-5 css-nar7n6-MuiGrid2-root"><div class="MuiGrid2-root MuiGrid2-container MuiGrid2-direction-xs-row css-28t11z-MuiGrid2-root"><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-mobile-4 MuiGrid2-grid-tablet-8 MuiGrid2-grid-desktop-5 css-4lhy0n-MuiGrid2-root"><h2 class="MuiTypography-root MuiTypography-h2 css-1te8woh-MuiTypography-root">Quels sont les risques pour les participants ?</h2></div><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-mobile-4 MuiGrid2-grid-tablet-8 MuiGrid2-grid-desktop-5 css-4lhy0n-MuiGrid2-root"><div><p class="MuiTypography-root MuiTypography-body1 css-1h3p22q-MuiTypography-root">Un essai clinique ne peut être mené que si toutes les précautions possibles ont été prises pour protéger la sécurité des patients, et un médicament expérimental ne peut être testé que s'il existe une réelle possibilité de bénéfice thérapeutique. Tous les essais cliniques sont menés conformément aux principes des bonnes pratiques cliniques (BPC), qui sont supervisés par des comités d'éthique indépendants (CEI et IRB).</p> </div></div></div></div></div></div><div class="dotcom-card-list MuiBox-root css-2pk4zw"><div class="MuiGrid2-root MuiGrid2-container MuiGrid2-direction-xs-row css-cr2kt9-MuiGrid2-root" id="3462e401-63dc-45f3-847d-e91fae6facc6"><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-desktop-12 MuiGrid2-grid-tablet-8 MuiGrid2-grid-mobile-4 css-epopls-MuiGrid2-root"><div class="MuiGrid2-root MuiGrid2-container MuiGrid2-direction-xs-row css-1p7pyf5-MuiGrid2-root"><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-desktop-4 MuiGrid2-grid-tablet-4 MuiGrid2-grid-mobile-4 css-hut50f-MuiGrid2-root"><div class="MuiBox-root css-w85lws"><div style="display:flex;flex-direction:column;width:100%;border-radius:8px;background-color:transparent" class="elements-ds-1bm7awf"><div style="justify-content:space-between;flex-direction:column;flex-grow:1;text-align:start" class="elements-ds-1etv3an"><div class="MuiBox-root css-0"><h5 style="overflow-wrap:break-word" class="elements-ds-1lhzxg5">Information</h5><div class="MuiTypography-root MuiTypography-body1 css-1ubkcfk-MuiTypography-root"><div>Le médecin qui dirige un essai clinique veille à ce que chaque patient invité à participer reçoive des informations sur les effets indésirables potentiels et ait le temps de réfléchir aux risques. </div></div></div></div></div></div></div><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-desktop-4 MuiGrid2-grid-tablet-4 MuiGrid2-grid-mobile-4 css-hut50f-MuiGrid2-root"><div class="MuiBox-root css-w85lws"><div style="display:flex;flex-direction:column;width:100%;border-radius:8px;background-color:transparent" class="elements-ds-1bm7awf"><div style="justify-content:space-between;flex-direction:column;flex-grow:1;text-align:start" class="elements-ds-1etv3an"><div class="MuiBox-root css-0"><h5 style="overflow-wrap:break-word" class="elements-ds-1lhzxg5">Considération </h5><div class="MuiTypography-root MuiTypography-body1 css-1ubkcfk-MuiTypography-root"><div>Les patients disposent d'un temps de réflexion avant de décider de participer ou non à un essai. S'ils décident de participer, on leur explique les risques et on leur demande de confirmer qu'ils sont conscients des procédures, des risques et des contraintes de l'étude. </div></div></div></div></div></div></div><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-desktop-4 MuiGrid2-grid-tablet-4 MuiGrid2-grid-mobile-4 css-hut50f-MuiGrid2-root"><div class="MuiBox-root css-w85lws"><div style="display:flex;flex-direction:column;width:100%;border-radius:8px;background-color:transparent" class="elements-ds-1bm7awf"><div style="justify-content:space-between;flex-direction:column;flex-grow:1;text-align:start" class="elements-ds-1etv3an"><div class="MuiBox-root css-0"><h5 style="overflow-wrap:break-word" class="elements-ds-1lhzxg5">Participation </h5><div class="MuiTypography-root MuiTypography-body1 css-1ubkcfk-MuiTypography-root"><div>Les patients qui participent à des essais cliniques bénéficient du plus haut degré de protection tout au long de l'étude grâce à une supervision biologique, médicale et clinique. Les patients peuvent décider à tout moment de se retirer de l'étude.</div></div></div><div class="MuiBox-root css-iey10y"><a class="elements-ds-dgpxh5" target="_blank" title="https://www.sanofistudies.com/us/en/" href="https://www.sanofistudies.com/us/en/" icon="fasArrowUpRightFromSquare"><span style="margin-inline-end:0">En savoir plus sur les études de Sanofi</span><svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="arrow-up-right-from-square" class="svg-inline--fa fa-arrow-up-right-from-square elements-ds-1i9a2yw" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 0c-17.7 0-32 14.3-32 32s14.3 32 32 32h82.7L201.4 265.4c-12.5 12.5-12.5 32.8 0 45.3s32.8 12.5 45.3 0L448 109.3V192c0 17.7 14.3 32 32 32s32-14.3 32-32V32c0-17.7-14.3-32-32-32H320zM80 32C35.8 32 0 67.8 0 112V432c0 44.2 35.8 80 80 80H400c44.2 0 80-35.8 80-80V320c0-17.7-14.3-32-32-32s-32 14.3-32 32V432c0 8.8-7.2 16-16 16H80c-8.8 0-16-7.2-16-16V112c0-8.8 7.2-16 16-16H192c17.7 0 32-14.3 32-32s-14.3-32-32-32H80z"></path></svg></a></div></div></div></div></div></div></div></div></div><div class="dotcom-content-block MuiBox-root css-jqikz1"><div class="MuiGrid2-root MuiGrid2-container MuiGrid2-direction-xs-row-reverse css-2wefi0-MuiGrid2-root" id="ecbf19ff-256f-4c3d-93ba-69fa231026b9"><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-mobile-4 MuiGrid2-grid-tablet-8 MuiGrid2-grid-desktop-7 css-1slqh4o-MuiGrid2-root"><div class="css-146e6e"><img src="/optim/dotcom/pages/images/our-science/clinical-trials-and-results/clinical-trials-and-results-shao_20230810131905.jpg?size=large" alt="" loading="lazy" class="css-6ijlax"/></div><span class="MuiTypography-root MuiTypography-caption css-vllrlk-MuiTypography-root">Shao-min et Shao-Chi, patients atteints d'Hemophilia A, Taiwan</span></div><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-mobile-4 MuiGrid2-grid-tablet-8 MuiGrid2-grid-desktop-5 css-nar7n6-MuiGrid2-root"><div class="MuiGrid2-root MuiGrid2-container MuiGrid2-direction-xs-row css-4bcpxk-MuiGrid2-root"><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-mobile-4 MuiGrid2-grid-tablet-8 MuiGrid2-grid-desktop-5 css-4lhy0n-MuiGrid2-root"><h2 class="MuiTypography-root MuiTypography-h2 css-1te8woh-MuiTypography-root">Comment les patients peuvent-ils participer ?</h2></div><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-mobile-4 MuiGrid2-grid-tablet-8 MuiGrid2-grid-desktop-5 css-4lhy0n-MuiGrid2-root"><div><p class="MuiTypography-root MuiTypography-body1 css-1h3p22q-MuiTypography-root">Les patients sont informés par leur médecin des essais cliniques qui pourraient leur convenir. Ceux-ci peuvent décider d’y participer pour bénéficier d’un traitement innovant, en particulier s’il n’existe que peu ou pas d’options thérapeutiques pour leur maladie. Ils peuvent également décider de prendre part à l’étude par souhait de soutenir la communauté ou de contribuer à la recherche d’un traitement spécifique.</p> <p class="MuiTypography-root MuiTypography-body1 css-sqijso-MuiTypography-root">Sanofi partage ses informations sur les essais cliniques dans des registres publics en libre<br/> accès, notamment :</p> <ul class="MuiTypography-root MuiTypography-body1 css-sqijso-MuiTypography-root"> <li class="MuiTypography-root MuiTypography-body1 css-1ubkcfk-MuiTypography-root">Le <a class="elements-ds-rtmnu6" href="https://www.clinicaltrialsregister.eu/">registre des essais cliniques en UE</a></li> <li class="MuiTypography-root MuiTypography-body1 css-1ubkcfk-MuiTypography-root">Le <a class="elements-ds-rtmnu6" href="https://www.clinicaltrials.gov/">registre des essais cliniques aux États-Unis</a></li> <li class="MuiTypography-root MuiTypography-body1 css-1ubkcfk-MuiTypography-root">Des registres supervisés par l’Organisation mondiale de la santé</li> <li class="MuiTypography-root MuiTypography-body1 css-1ubkcfk-MuiTypography-root">D’autres registres nationaux</li> </ul> </div></div></div></div></div></div><div class="dotcom-content-block MuiBox-root css-cpd9ss"><div class="MuiGrid2-root MuiGrid2-container MuiGrid2-direction-xs-row css-cr2kt9-MuiGrid2-root" id="789250c3-b1a9-4a43-aa39-bc21757fb6b8"><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-mobile-4 MuiGrid2-grid-tablet-8 MuiGrid2-grid-desktop-8 css-c8gmj9-MuiGrid2-root"><div><p class="MuiTypography-root MuiTypography-body1 css-1h3p22q-MuiTypography-root">Les essais cliniques de Sanofi sont conçus pour soigner les patients, pas les maladies. Lorsqu’elles conçoivent une étude, nos équipes tiennent compte de l’environnement des patients, notamment de l’accessibilité des transports et des locaux. Par exemple, si un patient peut seulement participer à distance, il peut être envisagé de recourir à des outils tels que la signature électronique, l’expédition de médicaments à prise orale et la télémédecine pour maintenir un lien entre le patient et les médecins. C’est pourquoi nos équipes affinent leur approche de la télémédecine car les médecins doivent souvent s’appuyer sur la détection d’indices visuels subtils pour effectuer leurs diagnostics.</p> </div></div></div></div><div class="dotcom-content-block MuiBox-root css-jqikz1"><div class="MuiGrid2-root MuiGrid2-container MuiGrid2-direction-xs-row css-1dgjf7h-MuiGrid2-root" id="3d8da33b-ad93-48f5-a79c-fee5568bba56"><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-mobile-4 MuiGrid2-grid-tablet-8 MuiGrid2-grid-desktop-7 css-1slqh4o-MuiGrid2-root"><div class="css-tdwhzg"><img src="/optim/dotcom/pages/images/our-science/clinical-trials-and-results/clinical-trials-of-amlitelimab/logo-oceana-trials-amlitelimab_20240215110546.jpg?size=large" alt="" loading="lazy" class="css-6ijlax"/></div></div><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-mobile-4 MuiGrid2-grid-tablet-8 MuiGrid2-grid-desktop-5 css-nar7n6-MuiGrid2-root"><div class="MuiGrid2-root MuiGrid2-container MuiGrid2-direction-xs-row css-28t11z-MuiGrid2-root"><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-mobile-4 MuiGrid2-grid-tablet-8 MuiGrid2-grid-desktop-5 css-4lhy0n-MuiGrid2-root"><h2 class="MuiTypography-root MuiTypography-h2 css-1te8woh-MuiTypography-root">OCEANA Clinical Program</h2></div><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-mobile-4 MuiGrid2-grid-tablet-8 MuiGrid2-grid-desktop-5 css-4lhy0n-MuiGrid2-root"><div><p class="MuiTypography-root MuiTypography-body1 css-1h3p22q-MuiTypography-root">Le programme de développement clinique OCEANA - Phase 2 et 3 vise à évaluer l'efficacité et l'innocuité d'une thérapie potentielle chez les patients atteints de dermatite atopique modérée à sévère.</p> <p class="MuiTypography-root MuiTypography-body1 css-sqijso-MuiTypography-root"><em>En cliquant sur le lien ci-dessous, vous attestez que vous êtes un professionnel de la santé.</em></p> </div></div><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-mobile-4 MuiGrid2-grid-tablet-8 MuiGrid2-grid-desktop-5 css-uysi7-MuiGrid2-root"><a class="elements-ds-dgpxh5" title="OCEANA Clinical Program Investigating amlitelimab in Atopic Dermatitis " icon="fasArrowRight" data-discover="true" href="/fr/notre-science/essais-cliniques-et-resultats/oceana-clinical-program-investigating-amlitelimab-in-atopic-dermatitis" target="_self"><span style="margin-inline-end:0">Find out more</span><svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="arrow-right" class="svg-inline--fa fa-arrow-right elements-ds-1i9a2yw" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M438.6 278.6c12.5-12.5 12.5-32.8 0-45.3l-160-160c-12.5-12.5-32.8-12.5-45.3 0s-12.5 32.8 0 45.3L338.8 224 32 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l306.7 0L233.4 393.4c-12.5 12.5-12.5 32.8 0 45.3s32.8 12.5 45.3 0l160-160z"></path></svg></a></div></div></div></div></div><div class="dotcom-focused-block MuiBox-root css-jqikz1"><div class="MuiGrid2-root MuiGrid2-container MuiGrid2-direction-xs-row css-1ri9qdm-MuiGrid2-root" id="52099a4b-c3a2-4311-88f1-2f5e8e4d51b9"><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-mobile-4 MuiGrid2-grid-tablet-8 MuiGrid2-grid-desktop-12 css-epopls-MuiGrid2-root"><h2 class="MuiTypography-root MuiTypography-h2 css-18fz9jt-MuiTypography-root">Vous souhaitez participer à un essai clinique chez Sanofi ?</h2></div><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-desktop-12 MuiGrid2-grid-tablet-8 MuiGrid2-grid-mobile-4 css-gx4bfz-MuiGrid2-root"><button class="elements-ds-twdzwl"><svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="arrow-up-right-from-square" class="svg-inline--fa fa-arrow-up-right-from-square elements-ds-9lhz6f" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 0c-17.7 0-32 14.3-32 32s14.3 32 32 32h82.7L201.4 265.4c-12.5 12.5-12.5 32.8 0 45.3s32.8 12.5 45.3 0L448 109.3V192c0 17.7 14.3 32 32 32s32-14.3 32-32V32c0-17.7-14.3-32-32-32H320zM80 32C35.8 32 0 67.8 0 112V432c0 44.2 35.8 80 80 80H400c44.2 0 80-35.8 80-80V320c0-17.7-14.3-32-32-32s-32 14.3-32 32V432c0 8.8-7.2 16-16 16H80c-8.8 0-16-7.2-16-16V112c0-8.8 7.2-16 16-16H192c17.7 0 32-14.3 32-32s-14.3-32-32-32H80z"></path></svg><a target="_blank" title="https://www.sanofistudies.com/global/en/" href="https://www.sanofistudies.com/global/en/">Découvrez comment participer</a></button></div></div></div><div class="dotcom-card-list MuiBox-root css-jqikz1"><div class="MuiGrid2-root MuiGrid2-container MuiGrid2-direction-xs-row css-cr2kt9-MuiGrid2-root" id="4c748988-99e9-4f2c-b08a-3fee5c41e46b"><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-desktop-12 MuiGrid2-grid-tablet-8 MuiGrid2-grid-mobile-4 css-epopls-MuiGrid2-root"><h2 class="MuiTypography-root MuiTypography-h2 css-1te8woh-MuiTypography-root">En savoir plus</h2></div><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-desktop-12 MuiGrid2-grid-tablet-8 MuiGrid2-grid-mobile-4 css-epopls-MuiGrid2-root"><div class="MuiGrid2-root MuiGrid2-container MuiGrid2-direction-xs-row css-1p7pyf5-MuiGrid2-root"><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-desktop-4 MuiGrid2-grid-tablet-4 MuiGrid2-grid-mobile-4 css-hut50f-MuiGrid2-root"><div class="MuiBox-root css-w85lws"><div style="display:flex;flex-direction:column;width:100%;border-radius:8px;background-color:transparent" class="elements-ds-1bm7awf"><div style="justify-content:space-between;flex-direction:column;flex-grow:1;text-align:start" class="elements-ds-1etv3an"><div class="MuiBox-root css-0"><h3 style="overflow-wrap:break-word" class="elements-ds-y51ixc">Nos engagements de partage de données</h3></div><div class="MuiBox-root css-iey10y"><a class="elements-ds-dgpxh5" title="Nos engagements de publication" icon="fasArrowRight" data-discover="true" href="/fr/notre-science/essais-cliniques-et-resultats/nos-engagements-de-publication" target="_self"><span style="margin-inline-end:0">En savoir plus</span><svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="arrow-right" class="svg-inline--fa fa-arrow-right elements-ds-1i9a2yw" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M438.6 278.6c12.5-12.5 12.5-32.8 0-45.3l-160-160c-12.5-12.5-32.8-12.5-45.3 0s-12.5 32.8 0 45.3L338.8 224 32 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l306.7 0L233.4 393.4c-12.5 12.5-12.5 32.8 0 45.3s32.8 12.5 45.3 0l160-160z"></path></svg></a></div></div></div></div></div><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-desktop-4 MuiGrid2-grid-tablet-4 MuiGrid2-grid-mobile-4 css-hut50f-MuiGrid2-root"><div class="MuiBox-root css-w85lws"><div style="display:flex;flex-direction:column;width:100%;border-radius:8px;background-color:transparent" class="elements-ds-1bm7awf"><div style="justify-content:space-between;flex-direction:column;flex-grow:1;text-align:start" class="elements-ds-1etv3an"><div class="MuiBox-root css-0"><h3 style="overflow-wrap:break-word" class="elements-ds-y51ixc">R&D Computer Systems</h3></div><div class="MuiBox-root css-iey10y"><a class="elements-ds-dgpxh5" title="R&D Computer Systems" icon="fasArrowRight" data-discover="true" href="/fr/rndcomputersystems" target="_self"><span style="margin-inline-end:0">En savoir plus</span><svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="arrow-right" class="svg-inline--fa fa-arrow-right elements-ds-1i9a2yw" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M438.6 278.6c12.5-12.5 12.5-32.8 0-45.3l-160-160c-12.5-12.5-32.8-12.5-45.3 0s-12.5 32.8 0 45.3L338.8 224 32 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l306.7 0L233.4 393.4c-12.5 12.5-12.5 32.8 0 45.3s32.8 12.5 45.3 0l160-160z"></path></svg></a></div></div></div></div></div><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-desktop-4 MuiGrid2-grid-tablet-4 MuiGrid2-grid-mobile-4 css-hut50f-MuiGrid2-root"><div class="MuiBox-root css-w85lws"><div style="display:flex;flex-direction:column;width:100%;border-radius:8px;background-color:transparent" class="elements-ds-1bm7awf"><div style="justify-content:space-between;flex-direction:column;flex-grow:1;text-align:start" class="elements-ds-1etv3an"><div class="MuiBox-root css-0"><h3 style="overflow-wrap:break-word" class="elements-ds-y51ixc">La fabrication d’un vaccin est un processus complexe</h3></div><div class="MuiBox-root css-iey10y"><a class="elements-ds-dgpxh5" title="Créer des vaccins au service de la santé publique" icon="fasArrowRight" data-discover="true" href="/fr/votre-sante/vaccins/production" target="_self"><span style="margin-inline-end:0">En savoir plus</span><svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="arrow-right" class="svg-inline--fa fa-arrow-right elements-ds-1i9a2yw" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M438.6 278.6c12.5-12.5 12.5-32.8 0-45.3l-160-160c-12.5-12.5-32.8-12.5-45.3 0s-12.5 32.8 0 45.3L338.8 224 32 224c-17.7 0-32 14.3-32 32s14.3 32 32 32l306.7 0L233.4 393.4c-12.5 12.5-12.5 32.8 0 45.3s32.8 12.5 45.3 0l160-160z"></path></svg></a></div></div></div></div></div><div class="MuiGrid2-root MuiGrid2-direction-xs-row MuiGrid2-grid-desktop-4 MuiGrid2-grid-tablet-4 MuiGrid2-grid-mobile-4 css-hut50f-MuiGrid2-root"><div class="MuiBox-root css-w85lws"><div style="display:flex;flex-direction:column;width:100%;border-radius:8px;background-color:transparent" class="elements-ds-1bm7awf"><div style="justify-content:space-between;flex-direction:column;flex-grow:1;text-align:start" class="elements-ds-1etv3an"><div class="MuiBox-root css-0"><h3 style="overflow-wrap:break-word" class="elements-ds-y51ixc">Programme d’Accès Géré pour des produits non autorisés</h3></div><div 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Cette \u0026eacute;tape essentielle \u0026agrave; la cr\u0026eacute;ation d\u0026rsquo;un nouveau m\u0026eacute;dicament ou d\u0026rsquo;un vaccin intervient apr\u0026egrave;s de nombreuses ann\u0026eacute;es, parfois des d\u0026eacute;cennies de recherche. Les personnes qui participent aux essais cliniques apportent une contribution inestimable car ils aident \u0026agrave; faire progresser la science et la m\u0026eacute;decine, et \u0026agrave; \u0026eacute;laborer de nouveaux traitements pour la sant\u0026eacute; de tous.\u003c/p\u003e\n\n\u003cp\u003eLes patients sont au c\u0026oelig;ur de la d\u0026eacute;marche scientifique chez Sanofi. Nos \u0026eacute;quipes de recherche et d\u0026eacute;veloppement travaillent aupr\u0026egrave;s des patients pour comprendre pleinement leurs priorit\u0026eacute;s, leurs exp\u0026eacute;riences, leurs besoins et les d\u0026eacute;fis auxquels ils font face. C\u0026rsquo;est en \u0026eacute;tant \u0026agrave; l\u0026rsquo;\u0026eacute;coute des patients et en traduisant leurs id\u0026eacute;es en actions, que ce soit au tout d\u0026eacute;but du d\u0026eacute;veloppement des essais cliniques ou au bien au-del\u0026agrave;, que nos chercheurs peuvent \u0026eacute;laborer de nouvelles solutions th\u0026eacute;rapeutiques qui pr\u0026eacute;sentent des r\u0026eacute;sultats positifs, r\u0026eacute;pondre aux besoins non satisfaits et am\u0026eacute;liorer la qualit\u0026eacute; de vie des patients.\u003c/p\u003e\n","caption":"De gauche à droite : Ingo, maladie de Pompe, Australie - Amit, asthme, Israël - Alfie, déficit en sphingomyélinase acide, Royaume-Uni - Danielle, myélome multiple, États-Unis - Ron, carcinome épidermoïde cutané, États-Unis - Hsieh, maladie de Fabry, Taïwan - Miwako, dermatite atopique, Japon - Jeff, asthme, Canada - Elizabeth, dermatite atopique, États-Unis - Dave, sclérose en plaques, Royaume-Uni - Cassie, sclérose en plaques, Australie - JJ, patient ASMD, États-Unis - Dov, sclérose en plaques, Israël - Jenny, sclérose en plaques thrombotique thrombotique acquise, Israël Dave, sclérose en plaques, Royaume-Uni - Cassie, sclérose en plaques, Australie - JJ, patient ASMD, États-Unis - Dov, sclérose en plaques, Israël - Jenny, purpura thrombocytopénique thrombotique acquis, États-Unis - Stephan, hémophilie, Kenya - Jodie, maladie de l'agglutinine froide, États-Unis - Brad, maladie de l'agglutinine froide, Canada - Schlomit, myélome multiple, Israël","image":"/assets/dotcom/pages/images/our-science/clinical-trials-and-results/herobanner-clinical-trials-results-06_20230811055916.jpg","videoPlay":"Jouer la vidéo","usePoster":false,"variation":"image-centered","tableLines":[],"htmlId":"df51e37a-0a68-4ff2-8614-36e0a1b22b94","imageContentAlignement":"flex-start","imageContentGridRatio":{"mobile":"4-4","tablet":"8-8","desktop":"7-5"},"imageRatio":"16/9","display":{"type":"none"},"linkVariation":"standalone","borderRadius":1,"textToWhite":false},{"cmsComponentType":"content-block","headingLevel":"h2","text":"\u003cp\u003eAvant d\u0026rsquo;\u0026ecirc;tre mis \u0026agrave; la disposition des patients, les nouveaux traitements doivent tout d\u0026rsquo;abord \u0026ecirc;tre test\u0026eacute;s pour garantir leur efficacit\u0026eacute; et leur bonne tol\u0026eacute;rabilit\u0026eacute;. L\u0026rsquo;essai clinique \u0026ndash; ou \u0026eacute;tude sur des humains \u0026ndash; constitue ainsi une \u0026eacute;tape cl\u0026eacute; du processus d\u0026rsquo;approbation de potentiels traitements par les autorit\u0026eacute;s sanitaires. Le traitement, ou \u0026laquo; produit candidat \u0026raquo;, peut \u0026ecirc;tre un nouveau vaccin, un m\u0026eacute;dicament, une combinaison de m\u0026eacute;dicaments, voire m\u0026ecirc;me une nouvelle application d\u0026rsquo;un compos\u0026eacute; existant.\u003c/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eUn essai clinique doit permettre\u003c/strong\u003e :\u003c/p\u003e\n\n\u003cul\u003e\n\t\u003cli\u003ede valider le nouveau m\u0026eacute;dicament ou vaccin, ou\u003c/li\u003e\n\t\u003cli\u003ede d\u0026eacute;finir les populations de patients au sein desquelles le traitement potentiel peut \u0026ecirc;tre le plus efficace.\u003c/li\u003e\n\u003c/ul\u003e\n\n\u003cp\u003eDans le cadre de l\u0026rsquo;\u0026eacute;tude, l\u0026rsquo;effet du produit candidat est compar\u0026eacute; soit \u0026agrave; un placebo (une substance sans activit\u0026eacute; pharmacologique) soit \u0026agrave; un traitement existant, afin d\u0026rsquo;\u0026eacute;valuer son innocuit\u0026eacute; et son efficacit\u0026eacute;. Durant un essai clinique complet, les chercheurs visent \u0026agrave; d\u0026eacute;terminer :\u003c/p\u003e\n\n\u003cul\u003e\n\t\u003cli\u003ela posologie la plus efficace,\u003c/li\u003e\n\t\u003cli\u003esa toxicit\u0026eacute; \u0026eacute;ventuelle, et la nature et la fr\u0026eacute;quence des effets ind\u0026eacute;sirables qu\u0026rsquo;il peut entra\u0026icirc;ner.\u003c/li\u003e\n\u003c/ul\u003e\n","title":"Qu’est-ce qu’un essai clinique ?","caption":"Swathi, patiente atteinte de la maladie de la Pompe","image":"/assets/dotcom/pages/images/our-science/clinical-trials-and-results/clinical-trials-and-results-swathi_20230810131700.jpg","videoPlay":"Jouer la vidéo","usePoster":false,"variation":"image-right","tableLines":[],"htmlId":"aab79338-9ac0-4f40-9211-387a94527ed2","imageContentAlignement":"flex-start","imageContentGridRatio":{"mobile":"4-4","tablet":"8-8","desktop":"7-5"},"imageRatio":"16/9","display":{"type":"none"},"linkVariation":"standalone","borderRadius":1,"textToWhite":false},{"cmsComponentType":"focused-block","headingLevel":"h2","heading":"Vous souhaitez participer à un essai clinique chez Sanofi ?","variation":"background","childCardVariation":"icon-card","cta":{"type":"external","url":"https://www.sanofistudies.com/global/en/","label":"Découvrez comment participer","target":"_blank","title":"https://www.sanofistudies.com/global/en/","icon":"fasArrowUpRightFromSquare","showOutgoingModal":false},"iconCards":[],"gtmPayload":{"event":"outbound_link","url":"https://www.sanofistudies.com/global/en/","Interaction_type":"outbound_link"},"htmlId":"3d8a1183-36af-495f-ac61-0e9bbbdb64f6"},{"cmsComponentType":"content-block","headingLevel":"h2","text":"\u003cp\u003ePour qu\u0026rsquo;un essai clinique puisse \u0026ecirc;tre lanc\u0026eacute;, des \u0026eacute;tudes de laboratoire doivent avoir fourni des r\u0026eacute;sultats satisfaisants ou sup\u0026eacute;rieurs aux exigences les plus rigoureuses, telles que fix\u0026eacute;es par les autorit\u0026eacute;s r\u0026eacute;glementaires.\u003c/p\u003e\n\n\u003cul\u003e\n\t\u003cli\u003eLes \u0026eacute;tudes en laboratoire sont con\u0026ccedil;ues pour \u0026eacute;valuer des compos\u0026eacute;s ou combinaisons de compos\u0026eacute;s \u0026ndash; sp\u0026eacute;cifiques, et ce, de diverses mani\u0026egrave;res. En effectuant des tests \u0026laquo; in vitro \u0026raquo; et des exp\u0026eacute;rimentations animales, les scientifiques peuvent \u0026eacute;valuer la tol\u0026eacute;rabilit\u0026eacute; de ces compos\u0026eacute;s, et d\u0026eacute;terminer si ceux-ci pr\u0026eacute;sentent une valeur th\u0026eacute;rapeutique ou pr\u0026eacute;ventive potentielle. Si toutes les donn\u0026eacute;es produites sont satisfaisantes, l\u0026rsquo;\u0026eacute;tape suivante consiste \u0026agrave; envisager des tests impliquant des volontaires sains ou des patients.\u003c/li\u003e\n\t\u003cli\u003e\u0026Agrave; ce stade, le fabricant soumet une demande \u0026agrave; un comit\u0026eacute; d\u0026rsquo;\u0026eacute;thique ind\u0026eacute;pendant (CEI) ou \u0026agrave; un comit\u0026eacute; de protection des personnes (CPP). Ces organismes totalement ind\u0026eacute;pendants examinent les proc\u0026eacute;dures et les protocoles d\u0026rsquo;essai. Leur d\u0026eacute;cision d\u0026rsquo;autoriser ou non l\u0026rsquo;essai clinique d\u0026rsquo;un compos\u0026eacute; se base sur la protection accord\u0026eacute;e aux participants et sur le besoin d\u0026rsquo;une nouvelle solution th\u0026eacute;rapeutique ou pr\u0026eacute;ventive. Pour en savoir plus sur la mani\u0026egrave;re dont les activit\u0026eacute;s m\u0026eacute;dicales et de R\u0026amp;D de Sanofi sont men\u0026eacute;es : \u003ca href=\"https://www.sanofi.com/assets/dotcom/content-app/documents/Medical-Ethics-Bioethics-and-Clinical-Trials.pdf\" style=\"color:#0563c1; text-decoration:underline\"\u003efiche d\u0026#39;information sur l\u0026#39;\u0026eacute;thique m\u0026eacute;dicale et la bio\u0026eacute;thique\u003c/a\u003e.\u003c/li\u003e\n\t\u003cli\u003eUn essai clinique ne peut \u0026ecirc;tre effectu\u0026eacute; que s\u0026rsquo;il a \u0026eacute;t\u0026eacute; approuv\u0026eacute; par l\u0026rsquo;un de ces comit\u0026eacute;s, celui-ci devant ensuite suivre le d\u0026eacute;roulement de l\u0026rsquo;essai afin d\u0026rsquo;assurer la continuit\u0026eacute; de la s\u0026eacute;curit\u0026eacute; et du bien-\u0026ecirc;tre des participants.\u003c/li\u003e\n\u003c/ul\u003e\n","title":"Dans quels cas une étude clinique est-elle lancée ?","videoPlay":"Jouer la vidéo","usePoster":false,"variation":"text-alone","tableLines":[],"htmlId":"f02e8bc6-1c03-470d-9998-dceb7bf20645","imageContentAlignement":"flex-start","imageContentGridRatio":{"mobile":"4-4","tablet":"8-8","desktop":"7-5"},"imageRatio":"16/9","display":{"type":"none"},"linkVariation":"standalone","borderRadius":1,"textToWhite":false},{"cmsComponentType":"content-block","headingLevel":"h2","text":"\u003cp\u003eUn essai clinique ne peut \u0026ecirc;tre men\u0026eacute; que si toutes les pr\u0026eacute;cautions possibles ont \u0026eacute;t\u0026eacute; prises pour prot\u0026eacute;ger la s\u0026eacute;curit\u0026eacute; des patients, et un m\u0026eacute;dicament exp\u0026eacute;rimental ne peut \u0026ecirc;tre test\u0026eacute; que s\u0026#39;il existe une r\u0026eacute;elle possibilit\u0026eacute; de b\u0026eacute;n\u0026eacute;fice th\u0026eacute;rapeutique. Tous les essais cliniques sont men\u0026eacute;s conform\u0026eacute;ment aux principes des bonnes pratiques cliniques (BPC), qui sont supervis\u0026eacute;s par des comit\u0026eacute;s d\u0026#39;\u0026eacute;thique ind\u0026eacute;pendants (CEI et IRB).\u003c/p\u003e\n","title":"Quels sont les risques pour les participants ?","caption":"Anita, sclérose en plaques, Norvège","image":"/assets/dotcom/pages/images/our-science/clinical-trials-and-results/clinical-trials-and-results-anita_20230810131743.jpg","videoPlay":"Jouer la vidéo","usePoster":false,"variation":"image-left","tableLines":[],"htmlId":"cc10a980-5bb7-4e07-a95b-5d3d2a5c0131","imageContentAlignement":"flex-start","imageContentGridRatio":{"mobile":"4-4","tablet":"8-8","desktop":"7-5"},"imageRatio":"16/9","display":{"type":"none"},"linkVariation":"standalone","borderRadius":1,"textToWhite":false},{"cmsComponentType":"card-list","headingLevel":"h4","isTitleSorted":false,"isLinkLabelSorted":false,"variation":"content-card","useCarousel":false,"cardsDisposition":"1/3","cards":[{"cmsComponentType":"card","variation":"content-card","headingLevel":"h2","title":"Information","description":"Le médecin qui dirige un essai clinique veille à ce que chaque patient invité à participer reçoive des informations sur les effets indésirables potentiels et ait le temps de réfléchir aux risques. ","display":{},"ctaVariant":"standalone","borderRadius":1,"imageRatio":"16/9","imageMargin":false},{"cmsComponentType":"card","variation":"content-card","headingLevel":"h2","title":"Considération ","description":"Les patients disposent d'un temps de réflexion avant de décider de participer ou non à un essai. S'ils décident de participer, on leur explique les risques et on leur demande de confirmer qu'ils sont conscients des procédures, des risques et des contraintes de l'étude. ","display":{},"ctaVariant":"standalone","borderRadius":1,"imageRatio":"16/9","imageMargin":false},{"cmsComponentType":"card","variation":"content-card","headingLevel":"h2","title":"Participation ","description":"Les patients qui participent à des essais cliniques bénéficient du plus haut degré de protection tout au long de l'étude grâce à une supervision biologique, médicale et clinique. Les patients peuvent décider à tout moment de se retirer de l'étude.","cta":{"type":"external","url":"https://www.sanofistudies.com/us/en/","label":"En savoir plus sur les études de Sanofi","target":"_blank","title":"https://www.sanofistudies.com/us/en/","icon":"fasArrowUpRightFromSquare","showOutgoingModal":true},"display":{},"ctaVariant":"standalone","borderRadius":1,"imageRatio":"16/9","imageMargin":false}],"htmlId":"3462e401-63dc-45f3-847d-e91fae6facc6","display":{"type":"none"},"ctaVariant":"standalone","borderRadius":1},{"cmsComponentType":"content-block","headingLevel":"h2","text":"\u003cp\u003eLes patients sont inform\u0026eacute;s par leur m\u0026eacute;decin des essais cliniques qui pourraient leur convenir. Ceux-ci peuvent d\u0026eacute;cider d\u0026rsquo;y participer pour b\u0026eacute;n\u0026eacute;ficier d\u0026rsquo;un traitement innovant, en particulier s\u0026rsquo;il n\u0026rsquo;existe que peu ou pas d\u0026rsquo;options th\u0026eacute;rapeutiques pour leur maladie. Ils peuvent \u0026eacute;galement d\u0026eacute;cider de prendre part \u0026agrave; l\u0026rsquo;\u0026eacute;tude par souhait de soutenir la communaut\u0026eacute; ou de contribuer \u0026agrave; la recherche d\u0026rsquo;un traitement sp\u0026eacute;cifique.\u003c/p\u003e\n\n\u003cp\u003eSanofi partage ses informations sur les essais cliniques dans des registres publics en libre\u003cbr /\u003e\nacc\u0026egrave;s, notamment :\u003c/p\u003e\n\n\u003cul\u003e\n\t\u003cli\u003eLe\u0026nbsp;\u003ca href=\"https://www.clinicaltrialsregister.eu/\" target=\"_self\"\u003eregistre des essais cliniques en UE\u003c/a\u003e\u003c/li\u003e\n\t\u003cli\u003eLe\u0026nbsp;\u003ca href=\"https://www.clinicaltrials.gov/\" target=\"_self\"\u003eregistre des essais cliniques aux \u0026Eacute;tats-Unis\u003c/a\u003e\u003c/li\u003e\n\t\u003cli\u003eDes registres supervis\u0026eacute;s par l\u0026rsquo;Organisation mondiale de la sant\u0026eacute;\u003c/li\u003e\n\t\u003cli\u003eD\u0026rsquo;autres registres nationaux\u003c/li\u003e\n\u003c/ul\u003e\n","title":"Comment les patients peuvent-ils participer ?","caption":"Shao-min et Shao-Chi, patients atteints d'Hemophilia A, Taiwan","image":"/assets/dotcom/pages/images/our-science/clinical-trials-and-results/clinical-trials-and-results-shao_20230810131905.jpg","videoPlay":"Jouer la vidéo","usePoster":false,"variation":"image-right","tableLines":[],"htmlId":"ecbf19ff-256f-4c3d-93ba-69fa231026b9","imageContentAlignement":"flex-start","imageContentGridRatio":{"mobile":"4-4","tablet":"8-8","desktop":"7-5"},"imageRatio":"16/9","display":{"type":"none"},"linkVariation":"standalone","borderRadius":1,"textToWhite":false},{"cmsComponentType":"content-block","headingLevel":"h5","text":"\u003cp\u003eLes essais cliniques de Sanofi sont con\u0026ccedil;us pour soigner les patients, pas les maladies. Lorsqu\u0026rsquo;elles con\u0026ccedil;oivent une \u0026eacute;tude, nos \u0026eacute;quipes tiennent compte de l\u0026rsquo;environnement des patients, notamment de l\u0026rsquo;accessibilit\u0026eacute; des transports et des locaux. Par exemple, si un patient peut seulement participer \u0026agrave; distance, il peut \u0026ecirc;tre envisag\u0026eacute; de recourir \u0026agrave; des outils tels que la signature \u0026eacute;lectronique, l\u0026rsquo;exp\u0026eacute;dition de m\u0026eacute;dicaments \u0026agrave; prise orale et la t\u0026eacute;l\u0026eacute;m\u0026eacute;decine pour maintenir un lien entre le patient et les m\u0026eacute;decins. C\u0026rsquo;est pourquoi nos \u0026eacute;quipes affinent leur approche de la t\u0026eacute;l\u0026eacute;m\u0026eacute;decine car les m\u0026eacute;decins doivent souvent s\u0026rsquo;appuyer sur la d\u0026eacute;tection d\u0026rsquo;indices visuels subtils pour effectuer leurs diagnostics.\u003c/p\u003e\n","videoPlay":"Jouer la vidéo","usePoster":false,"variation":"text-alone","tableLines":[],"htmlId":"789250c3-b1a9-4a43-aa39-bc21757fb6b8","imageContentAlignement":"flex-start","imageContentGridRatio":{"mobile":"4-4","tablet":"8-8","desktop":"7-5"},"imageRatio":"16/9","display":{"type":"none"},"linkVariation":"standalone","borderRadius":1,"textToWhite":false},{"cmsComponentType":"content-block","headingLevel":"h2","text":"\u003cp\u003eLe programme de d\u0026eacute;veloppement clinique OCEANA - Phase 2 et 3 vise \u0026agrave; \u0026eacute;valuer l\u0026#39;efficacit\u0026eacute; et l\u0026#39;innocuit\u0026eacute; d\u0026#39;une th\u0026eacute;rapie potentielle chez les patients atteints de dermatite atopique mod\u0026eacute;r\u0026eacute;e \u0026agrave; s\u0026eacute;v\u0026egrave;re.\u003c/p\u003e\n\n\u003cp\u003e\u003cem\u003eEn cliquant sur le lien ci-dessous, vous attestez que vous \u0026ecirc;tes un professionnel de la sant\u0026eacute;.\u003c/em\u003e\u003c/p\u003e\n","title":"OCEANA Clinical Program","image":"/assets/dotcom/pages/images/our-science/clinical-trials-and-results/clinical-trials-of-amlitelimab/logo-oceana-trials-amlitelimab_20240215110546.jpg","videoPlay":"Jouer la vidéo","usePoster":false,"variation":"image-left","cta":{"type":"internal","url":"/fr/notre-science/essais-cliniques-et-resultats/oceana-clinical-program-investigating-amlitelimab-in-atopic-dermatitis","label":"Find out more","target":"_self","title":"OCEANA Clinical Program Investigating amlitelimab in Atopic Dermatitis ","icon":"fasArrowRight"},"tableLines":[],"htmlId":"3d8da33b-ad93-48f5-a79c-fee5568bba56","imageContentAlignement":"flex-start","imageContentGridRatio":{"mobile":"4-4","tablet":"8-8","desktop":"7-5"},"imageRatio":"16/9","display":{"type":"none"},"linkVariation":"standalone","borderRadius":1,"textToWhite":false},{"cmsComponentType":"focused-block","headingLevel":"h2","heading":"Vous souhaitez participer à un essai clinique chez Sanofi ?","variation":"background","childCardVariation":"icon-card","cta":{"type":"external","url":"https://www.sanofistudies.com/global/en/","label":"Découvrez comment participer","target":"_blank","title":"https://www.sanofistudies.com/global/en/","icon":"fasArrowUpRightFromSquare","showOutgoingModal":false},"iconCards":[],"gtmPayload":{"event":"outbound_link","url":"https://www.sanofistudies.com/global/en/","Interaction_type":"outbound_link"},"htmlId":"52099a4b-c3a2-4311-88f1-2f5e8e4d51b9"},{"cmsComponentType":"card-list","headingLevel":"h2","heading":"En savoir plus","isTitleSorted":false,"isLinkLabelSorted":false,"variation":"content-card","useCarousel":false,"cardsDisposition":"1/3","cards":[{"cmsComponentType":"card","variation":"content-card","headingLevel":"h2","title":"Nos engagements de partage de données","cta":{"type":"internal","url":"/fr/notre-science/essais-cliniques-et-resultats/nos-engagements-de-publication","label":"En savoir plus","target":"_self","title":"Nos engagements de publication","icon":"fasArrowRight"},"display":{},"ctaVariant":"standalone","borderRadius":1,"imageRatio":"16/9","imageMargin":false},{"cmsComponentType":"card","variation":"content-card","headingLevel":"h2","title":"R\u0026D Computer Systems","cta":{"type":"internal","url":"/fr/rndcomputersystems","label":"En savoir plus","target":"_self","title":"R\u0026D Computer Systems","icon":"fasArrowRight"},"display":{},"ctaVariant":"standalone","borderRadius":1,"imageRatio":"16/9","imageMargin":false},{"cmsComponentType":"card","variation":"content-card","headingLevel":"h2","title":"La fabrication d’un vaccin est un processus complexe","cta":{"type":"internal","url":"/fr/votre-sante/vaccins/production","label":"En savoir plus","target":"_self","title":"Créer des vaccins au service de la santé publique","icon":"fasArrowRight"},"display":{},"ctaVariant":"standalone","borderRadius":1,"imageRatio":"16/9","imageMargin":false},{"cmsComponentType":"card","variation":"content-card","headingLevel":"h2","title":"Programme d’Accès Géré pour des produits non autorisés","cta":{"type":"internal","url":"/fr/votre-sante/relations-avec-les-professionnels-de-sante/sanofi-managed-access-programme","label":"En savoir plus","target":"_self","title":"Managed Access Programs 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