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style="background-image: url('https://admescope.com/wp-content/uploads/sites/2/2023/08/Admescope-biologics-1.jpg');"> <div class="hero__content"> <div class="hero__heading"> <svg xmlns:xlink="http://www.w3.org/1999/xlink"><use xlink:href="#icon-services-biologics"></use></svg> <h1>Biologics</h1> </div> </div> </div> </div> <main class="wp-block-group main main--page is-layout-flow wp-block-group-is-layout-flow"> <div class="wp-block-group main__content is-layout-constrained wp-block-group-is-layout-constrained"> <div id="ez-toc-container" class="ez-toc-v2_0_69_1 counter-flat ez-toc-counter ez-toc-grey ez-toc-container-direction"> <div class="ez-toc-title-container"> <p class="ez-toc-title" style="cursor:inherit">Table of Contents</p> <span class="ez-toc-title-toggle"></span></div> <nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-1" href="#Our_services_for_Biologics_research" title="Our services for Biologics research">Our services for Biologics research</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-2" href="#ADC_Characterization" title="ADC Characterization">ADC Characterization</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-3" href="#Oligonucleotides" title="Oligonucleotides">Oligonucleotides</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-4" href="#Quantification_with_LCMS" title="Quantification with LC/MS">Quantification with LC/MS</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-5" href="#Quantification_with_ELISA" title="Quantification with ELISA">Quantification with ELISA</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-6" href="#Protein_Pharmacokinetics" title="Protein Pharmacokinetics">Protein Pharmacokinetics</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-7" href="#Protein_MW_and_Structural_Characterization_LCMS" title="Protein MW and Structural Characterization (LC/MS)">Protein MW and Structural Characterization (LC/MS)</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-8" href="#Peptide_Mapping_and_Detection_of_Post-translational_Modifications_LCMS" title="Peptide Mapping and Detection of Post-translational Modifications (LC/MS)">Peptide Mapping and Detection of Post-translational Modifications (LC/MS)</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-9" href="#Released_N-glycan_Profiling" title="Released N-glycan Profiling">Released N-glycan Profiling</a></li><li class='ez-toc-page-1'><a class="ez-toc-link ez-toc-heading-10" href="#Biomolecular_Interactions" title="Biomolecular Interactions">Biomolecular Interactions</a></li></ul></nav></div> <div class="entry-content wp-block-post-content is-layout-flow wp-block-post-content-is-layout-flow"> <h2 class="wp-block-heading"><span class="ez-toc-section" id="Our_services_for_Biologics_research"></span>Our services for Biologics research<span class="ez-toc-section-end"></span></h2> <p class="has-medium-font-size">Biological drugs include a wide range of drug modalities, such as peptides, monoclonal antibodies, proteins, and oligonucleotides, which require tailored experimental protocols and analytical techniques for their successful ADME-Tox and <em>in vivo</em> DMPK characterization.</p> <p class="has-medium-font-size">Regardless of the drug modality, we can support the project for investigating <a href="https://www.admescope.com/services/in-vitro-metabolism/#Metabolic_Stability" data-type="URL" data-id="https://www.admescope.com/services/in-vitro-metabolism/#Metabolic_Stability">metabolic stability</a>, <a href="https://www.admescope.com/services/physicochemistry-and-binding/#Plasma_Protein_Binding" data-type="URL" data-id="https://www.admescope.com/services/physicochemistry-and-binding/#Plasma_Protein_Binding">plasma protein binding</a>, <a href="https://www.admescope.com/services/drug-interactions/" data-type="URL" data-id="https://www.admescope.com/services/drug-interactions/">drug-drug interaction</a> studies and <em>in vivo</em> <a href="https://www.admescope.com/services/in-vivo-dmpk/" data-type="URL" data-id="https://www.admescope.com/services/in-vivo-dmpk/">pharmacokinetic studies</a>.</p> <p class="has-medium-font-size">Besides investigating ADME/DMPK properties, structural characterization is an essential part of the development process of larger biologics, such as mAbs and ADCs. Liquid chromatography – mass spectrometry (LC/MS) based techniques are excellent for this, providing unambiguous structural and quantitative information. Use of state-of-the-art analytical instrumentation and software allows straightforward sample analysis and delivers reliable high-quality results. In addition, enzyme-linked immunosorbent-assays (ELISA) are an efficient and convenient way to quantify proteins, when the needed antibody is available.</p> <p class="has-medium-font-size">In addition to structural characterization of biological drugs, we can also perform targeted protein quantification (LC/MS and ELISA), in vivo pharmacokinetic studies and biomolecular interactions, and characterize ADCs for their ADME properties.</p> <p class="has-medium-font-size">Reach out to us to discuss how we can support with your project!</p> <div style="height:10px" aria-hidden="true" class="wp-block-spacer"></div> <hr class="wp-block-separator has-text-color has-symeres-font-color has-alpha-channel-opacity has-symeres-font-background-color has-background is-style-wide" /> <div style="height:10px" aria-hidden="true" class="wp-block-spacer"></div> <h2 class="wp-block-heading"><span class="ez-toc-section" id="ADC_Characterization"></span><strong><strong>ADC Characterization</strong></strong><span class="ez-toc-section-end"></span></h2> <p class="has-medium-font-size">Antibody-drug conjugates (ADCs) consist of small molecules (warhead/payload) linked to antibodies. The linker between small molecule and the antibody affects the payload release mechanism via metabolic reactions. Therefore, when studying ADME properties of ADCs it´s important to identify the released metabolites, including unconjugated small molecule drug, small molecule conjugated to the linker or some parts of the linker, and small molecule conjugated to the linker and amino acid residues of the antibody. ADC catabolism is typically investigated in acidic conditions using liver S9 fraction and lysosomes. In vitro metabolite identification and profiling for payload and linker payload is conducted in neutral conditions with liver S9 fraction.</p> <figure class="wp-block-image alignleft size-full"><img fetchpriority="high" decoding="async" width="402" height="537" src="https://www.admescope.com/wp-content/uploads/sites/2/2023/05/biologics-1.png" alt="Admescope antibody-drug conjugates (ADCs) characterization services" class="wp-image-922" srcset="https://admescope.com/wp-content/uploads/sites/2/2023/05/biologics-1.png 402w, https://admescope.com/wp-content/uploads/sites/2/2023/05/biologics-1-225x300.png 225w" sizes="(max-width: 402px) 100vw, 402px" /></figure> <p class="has-medium-font-size">Depending on the conjugation strategy, the developed ADCs may vary in the number of payload conjugated per antibody molecule. The average number of payload in the antibody is defined as drug-antibody ratio (DAR). It is essential to define DAR since it affects the efficacy of ADCs and the metabolites. DAR can be determined by analyzing intact protein using LC-HR/MS. Prior to analysis, protein is typically enzymatically deglycosylated to remove carbohydrate structures since this simplifies the analysis.</p> <p class="has-medium-font-size">As well as studying how small molecules are released from ADCs, we can investigate rodent pharmacokinetics of ADCs in our in-house animal facilities.</p> <p></p> <div class="wp-block-buttons is-content-justification-left is-layout-flex wp-container-core-buttons-is-layout-9 wp-block-buttons-is-layout-flex"> <div class="wp-block-button has-custom-font-size is-style-outline has-gibson-font-family is-style-outline--9" style="font-size:18px;font-style:normal;font-weight:500;text-decoration:none;text-transform:none"><a class="wp-block-button__link has-symeres-white-color has-symeres-secondary-background-color has-text-color has-background wp-element-button" href="https://admeshop.com/collections/biologics" style="border-radius:100px" target="_blank" rel="noopener"><strong>Request a quote via our Admeshop</strong></a></div> </div> <div style="height:25px" aria-hidden="true" class="wp-block-spacer"></div> <section class="downloads downloadable-content-block"> <div class="downloads__list"> <form class="downloads"> <ul> <li> <input id="download-file-Admescope-ADC-characterization-factsheet.pdf" name="download" data-filetitle="Admescope ADC characterization factsheet" data-filename="Admescope-ADC-characterization-factsheet.pdf" data-download="2747" name="download-file" type="checkbox"> <label for="download-file-Admescope-ADC-characterization-factsheet.pdf"> Admescope ADC characterization factsheet <span> <svg class="downloads-unchecked"><use xlink:href="#downloads-checkbox-default"></use></svg> <svg class="downloads-checked"><use xlink:href="#downloads-checkbox-checked"></use></svg> </span> </label> </li> </ul> </form> </div> </section> <h2 class="wp-block-heading"><span class="ez-toc-section" id="Oligonucleotides"></span>Oligonucleotides<span class="ez-toc-section-end"></span></h2> <p class="has-medium-font-size">Despite oligonucleotides are different from traditional small molecules, it is crucial to investigate also their ADME-Tox/DMPK properties to avoid failure at the later stages due to poor ADME performance or safety issues. In particular, the metabolic stability, metabolite identification, plasma protein binding, and drug-drug interactions are typically evaluated. Admescope’s portfolio includes ADME-Tox and in vivo DMPK assays for oligonucleotides, as well as other drug modalities. Our experienced scientific team is equipped with <a href="https://admescope.com/services/our-analytical-equipment/" data-type="URL" data-id="https://admescope.com/services/our-analytical-equipment/">high-end analytical instrumentation</a> and available to support your oligonucleotide project.</p> <p class="has-medium-font-size">The <a href="https://admescope.com/services/in-vitro-metabolism/" data-type="URL" data-id="https://admescope.com/services/in-vitro-metabolism/">in vitro metabolism and metabolite identification</a> experiments for oligonucleotides are available with various enzymatic matrices, such as plasma, liver and kidney fractions. However, special considerations are needed when designing experimental protocols, sample treatment and analytical method development for oligonucleotides. Due to the high stability of therapeutic oligonucleotides with phosphorothioate or phosphorodiamidate morpholino backbone, long incubation times are typically used, and when applying cell-based models, co-culture models for low clearance compounds are recommended, as the incubation times can be extended over several days.</p> <p class="has-medium-font-size">For <a href="https://admescope.com/services/physicochemistry-and-binding/" data-type="URL" data-id="https://admescope.com/services/physicochemistry-and-binding/">plasma protein binding</a> determination of oligonucleotides, ultrafiltration method is a commonly used approach, using filters with 30 – 50 kDa cut-off suitable for oligonucleotides, and coupled with several pre-washing steps of the filter, e.g using a detergent solution. Our preclinical in vivo DMPK services for oligonucleotides include the whole study package; conduction of in-life part, bioanalysis with LC/MS or qPCR, data processing and reporting.</p> <div style="height:10px" aria-hidden="true" class="wp-block-spacer"></div> <hr class="wp-block-separator has-text-color has-symeres-font-color has-alpha-channel-opacity has-symeres-font-background-color has-background is-style-wide" /> <div style="height:10px" aria-hidden="true" class="wp-block-spacer"></div> <h2 class="wp-block-heading"><span class="ez-toc-section" id="Quantification_with_LCMS"></span>Quantification with LC/MS<span class="ez-toc-section-end"></span></h2> <p class="has-medium-font-size">To quantify proteins from biological matrixes, larger proteins (>10-20 kDa) are analyzed using digestion and surrogate peptide approach, whereas smaller proteins and peptides can be quantified as intact with UV with or without MS-detection, although the method of choice depends also on the sample matrix.</p> <p class="has-medium-font-size">Protein quantification using surrogate peptide approach with LC/MS starts with bioinformatics, instead of antibody sourcing or development like in traditional immunoassays (e.g., ELISA). Therefore, the method development time can be significantly shorter compared to the antibody-binding based analytical techniques. The target protein sequence is first compared with the sample matrix proteome and the predicted peptides, unique for the target protein, are identified. Next, the target protein is enriched, or the background proteome depleted using, for example, selective precipitation or solid phase extraction. This is followed by protein digestion, using sequence specific proteases, to liberate the predicted peptides from the target protein. The target protein quantification is then based on monitoring LC/MS signal of the unique target peptides.</p> <p></p> <div class="wp-block-buttons is-content-justification-left is-layout-flex wp-container-core-buttons-is-layout-10 wp-block-buttons-is-layout-flex"> <div class="wp-block-button has-custom-font-size is-style-outline has-gibson-font-family is-style-outline--10" style="font-size:18px;font-style:normal;font-weight:500;text-decoration:none;text-transform:none"><a class="wp-block-button__link has-symeres-white-color has-symeres-secondary-background-color has-text-color has-background wp-element-button" href="https://admeshop.com/collections/quantitative-bioanalysis" style="border-radius:100px" target="_blank" rel="noopener"><strong>Request a quote via our Admeshop</strong></a></div> </div> <p></p> <section class="downloads downloadable-content-block"> <div class="downloads__list"> <form class="downloads"> <ul> <li> <input id="download-file-Admescope-Targeted-protein-quantification-factsheet.pdf" name="download" data-filetitle="Admescope Targeted protein quantification factsheet" data-filename="Admescope-Targeted-protein-quantification-factsheet.pdf" data-download="2788" name="download-file" type="checkbox"> <label for="download-file-Admescope-Targeted-protein-quantification-factsheet.pdf"> Admescope Targeted protein quantification factsheet <span> <svg class="downloads-unchecked"><use xlink:href="#downloads-checkbox-default"></use></svg> <svg class="downloads-checked"><use xlink:href="#downloads-checkbox-checked"></use></svg> </span> </label> </li> </ul> </form> </div> </section> <figure class="wp-block-image alignright size-full"><img decoding="async" width="337" height="386" src="https://www.admescope.com/wp-content/uploads/sites/2/2023/05/biologics-3.png" alt="Admescope lab team employee working with quantification with ELISA" class="wp-image-933" srcset="https://admescope.com/wp-content/uploads/sites/2/2023/05/biologics-3.png 337w, https://admescope.com/wp-content/uploads/sites/2/2023/05/biologics-3-262x300.png 262w" sizes="(max-width: 337px) 100vw, 337px" /></figure> <h2 class="wp-block-heading"><span class="ez-toc-section" id="Quantification_with_ELISA"></span><strong>Quantification with ELISA</strong><span class="ez-toc-section-end"></span></h2> <p class="has-medium-font-size">ELISA methods have been applied for protein quantification from biological matrixes over decades. When an antibody for the target protein is available, quantification using ELISA is sensitive and specific alternative, requiring relatively low sample volumes.</p> <p class="has-medium-font-size">We offer protein quantification using commercially available ELISA kits, assays provided by the customer or we can develop ELISA methods when there is an antibody or antibody pair available for the target protein. The assays can be customized, optimized and verified according to your requirements.</p> <p class="has-medium-font-size">ELISA is an efficient technique and the results correlate with the LC/MS/MS approach. Optimal protein quantification would use two independent analysis (i.e., ELISA + LC/MS/MS).</p> <p></p> <div class="wp-block-buttons is-content-justification-left is-layout-flex wp-container-core-buttons-is-layout-11 wp-block-buttons-is-layout-flex"> <div class="wp-block-button has-custom-font-size is-style-outline has-gibson-font-family is-style-outline--11" style="font-size:18px;font-style:normal;font-weight:500;text-decoration:none;text-transform:none"><a class="wp-block-button__link has-symeres-white-color has-symeres-secondary-background-color has-text-color has-background wp-element-button" href="https://admeshop.com/collections/quantitative-bioanalysis" style="border-radius:100px" target="_blank" rel="noopener"><strong>Request a quote via our Admeshop</strong></a></div> </div> <p></p> <section class="downloads downloadable-content-block"> <div class="downloads__list"> <form class="downloads"> <ul> <li> <input id="download-file-Admescope-ELISA-quantification-factsheet.pdf" name="download" data-filetitle="Admescope ELISA quantification factsheet" data-filename="Admescope-ELISA-quantification-factsheet.pdf" data-download="2762" name="download-file" type="checkbox"> <label for="download-file-Admescope-ELISA-quantification-factsheet.pdf"> Admescope ELISA quantification factsheet <span> <svg class="downloads-unchecked"><use xlink:href="#downloads-checkbox-default"></use></svg> <svg class="downloads-checked"><use xlink:href="#downloads-checkbox-checked"></use></svg> </span> </label> </li> </ul> </form> </div> </section> <h2 class="wp-block-heading"><span class="ez-toc-section" id="Protein_Pharmacokinetics"></span><strong>Protein Pharmacokinetics</strong><span class="ez-toc-section-end"></span></h2> <p class="has-medium-font-size">Our in-house animal facilities enable us to perform protein PK studies with mice and rats, and other species are available via European subcontractors. In addition, we offer bioanalysis to quantify proteins and PK parameters can be calculated. For additional information, please go to <a href="https://admescope.com/services/in-vivo-dmpk/#Animal_Pharmacokinetics">animal pharmacokinetics</a>.</p> <p></p> <div class="wp-block-buttons is-content-justification-left is-layout-flex wp-container-core-buttons-is-layout-12 wp-block-buttons-is-layout-flex"> <div class="wp-block-button has-custom-font-size is-style-outline has-gibson-font-family is-style-outline--12" style="font-size:18px;font-style:normal;font-weight:500;text-decoration:none;text-transform:none"><a class="wp-block-button__link has-symeres-white-color has-symeres-secondary-background-color has-text-color has-background wp-element-button" href="https://admeshop.com/collections/in-vivo-dmpk" style="border-radius:100px" target="_blank" rel="noopener"><strong>Request a quote via our Admeshop</strong></a></div> </div> <p></p> <section class="downloads downloadable-content-block"> <div class="downloads__list"> <form class="downloads"> <ul> <li> <input id="download-file-Admescope-PKscreen-factsheet.pdf" name="download" data-filetitle="Admescope PKscreen factsheet" data-filename="Admescope-PKscreen-factsheet.pdf" data-download="2781" name="download-file" type="checkbox"> <label for="download-file-Admescope-PKscreen-factsheet.pdf"> Admescope PKscreen factsheet <span> <svg class="downloads-unchecked"><use xlink:href="#downloads-checkbox-default"></use></svg> <svg class="downloads-checked"><use xlink:href="#downloads-checkbox-checked"></use></svg> </span> </label> </li> <li> <input id="download-file-Admescope-PKlead-factsheet.pdf" name="download" data-filetitle="Admescope PKlead factsheet" data-filename="Admescope-PKlead-factsheet.pdf" data-download="2777" name="download-file" type="checkbox"> <label for="download-file-Admescope-PKlead-factsheet.pdf"> Admescope PKlead factsheet <span> <svg class="downloads-unchecked"><use xlink:href="#downloads-checkbox-default"></use></svg> <svg class="downloads-checked"><use xlink:href="#downloads-checkbox-checked"></use></svg> </span> </label> </li> </ul> </form> </div> </section> <h2 class="wp-block-heading"><span class="ez-toc-section" id="Protein_MW_and_Structural_Characterization_LCMS"></span>Protein MW and Structural Characterization (LC/MS)<span class="ez-toc-section-end"></span></h2> <p class="has-medium-font-size">Intact molecular weight analysis of protein by mass spectrometry is a fast and efficient way to confirm purity, homogeneity and molecular weight of the protein analyte. The samples are analyzed using high resolution LC/MS system. In the case of antibodies, various treatments can be applied to verify the molecular weights of heavy and light chains of the antibody or other enzymatically produced sub-units, to enable more precise characterization of the target molecule. In addition, the effect of different glycosylations or other post-translational modifications on the molecular weight can be observed.</p> <p></p> <div class="wp-block-buttons is-content-justification-left is-layout-flex wp-container-core-buttons-is-layout-13 wp-block-buttons-is-layout-flex"> <div class="wp-block-button has-custom-font-size is-style-outline has-gibson-font-family is-style-outline--13" style="font-size:18px;font-style:normal;font-weight:500;text-decoration:none;text-transform:none"><a class="wp-block-button__link has-symeres-white-color has-symeres-secondary-background-color has-text-color has-background wp-element-button" href="https://admeshop.com/collections/biologics" style="border-radius:100px" target="_blank" rel="noopener"><strong>Request a quote via our Admeshop</strong></a></div> </div> <p></p> <section class="downloads downloadable-content-block"> <div class="downloads__list"> <form class="downloads"> <ul> <li> <input id="download-file-Admescope-Protein-MW-characterisation-factsheet.pdf" name="download" data-filetitle="Admescope Protein MW characterisation factsheet" data-filename="Admescope-Protein-MW-characterisation-factsheet.pdf" data-download="2782" name="download-file" type="checkbox"> <label for="download-file-Admescope-Protein-MW-characterisation-factsheet.pdf"> Admescope Protein MW characterisation factsheet <span> <svg class="downloads-unchecked"><use xlink:href="#downloads-checkbox-default"></use></svg> <svg class="downloads-checked"><use xlink:href="#downloads-checkbox-checked"></use></svg> </span> </label> </li> </ul> </form> </div> </section> <h2 class="wp-block-heading"><span class="ez-toc-section" id="Peptide_Mapping_and_Detection_of_Post-translational_Modifications_LCMS"></span>Peptide Mapping and Detection of Post-translational Modifications (LC/MS)<span class="ez-toc-section-end"></span></h2> <figure class="wp-block-image alignright size-full"><img decoding="async" width="337" height="386" src="https://www.admescope.com/wp-content/uploads/sites/2/2023/05/biologics-2.png" alt="Admescope lab team members working with Peptide Mapping and Detection of Post-translational Modifications (LC/MS)" class="wp-image-928" srcset="https://admescope.com/wp-content/uploads/sites/2/2023/05/biologics-2.png 337w, https://admescope.com/wp-content/uploads/sites/2/2023/05/biologics-2-262x300.png 262w" sizes="(max-width: 337px) 100vw, 337px" /></figure> <p class="has-medium-font-size">To further help with the structural characterization of proteins, we provide peptide mapping to verify and elucidate the amino acid sequence of the target protein. This technique is also recognized by the International Council of Harmonization (ICHQ6B) as part of physicochemical characterization of biological products.</p> <p class="has-medium-font-size">Typically, the expected sequence of the target protein is mapped against experimental result of the target based on analysis of sequence-related peptides originating from digestions under several enzymatic conditions. In addition to the information of the primary structure, this analysis can detect the post translational modifications and their locations within the known sequence.</p> <p></p> <div class="wp-block-buttons is-content-justification-left is-layout-flex wp-container-core-buttons-is-layout-14 wp-block-buttons-is-layout-flex"> <div class="wp-block-button has-custom-font-size is-style-outline has-gibson-font-family is-style-outline--14" style="font-size:18px;font-style:normal;font-weight:500;text-decoration:none;text-transform:none"><a class="wp-block-button__link has-symeres-white-color has-symeres-secondary-background-color has-text-color has-background wp-element-button" href="https://admeshop.com/collections/biologics" style="border-radius:100px" target="_blank" rel="noopener"><strong>Request a quote via our Admeshop</strong></a></div> </div> <p></p> <section class="downloads downloadable-content-block"> <div class="downloads__list"> <form class="downloads"> <ul> <li> <input id="download-file-Admescope-Peptide-mapping-factsheet.pdf" name="download" data-filetitle="Admescope Peptide-mapping factsheet" data-filename="Admescope-Peptide-mapping-factsheet.pdf" data-download="2775" name="download-file" type="checkbox"> <label for="download-file-Admescope-Peptide-mapping-factsheet.pdf"> Admescope Peptide-mapping factsheet <span> <svg class="downloads-unchecked"><use xlink:href="#downloads-checkbox-default"></use></svg> <svg class="downloads-checked"><use xlink:href="#downloads-checkbox-checked"></use></svg> </span> </label> </li> </ul> </form> </div> </section> <h2 class="wp-block-heading"><span class="ez-toc-section" id="Released_N-glycan_Profiling"></span>Released N-glycan Profiling<span class="ez-toc-section-end"></span></h2> <p class="has-medium-font-size">Glycosylation is one of the most frequent protein post-translational modifications, which may affect the stability, immunogenicity, pharmacokinetics and biological activity of the protein. Therefore, comprehensive characterization and monitoring of glycans is an essential task in development of biologics. Characterization of released glycans provides more comprehensive information about the glycan profile in comparison to analysis of the intact glycoprotein.</p> <p class="has-medium-font-size">In the released N-glycan profiling, the protein is first deglycosylated to release N-glycans, which is followed by labelling, purification, and detection of the fluorophore labelled N-glycans. N-glycans are separated using chromatography and detected based on the sensitive fluorescence signal. A glycan library is used to identify the glycan structures based on their retention time and identification is confirmed with MS.</p> <p></p> <div class="wp-block-buttons is-content-justification-left is-layout-flex wp-container-core-buttons-is-layout-15 wp-block-buttons-is-layout-flex"> <div class="wp-block-button has-custom-font-size is-style-outline has-gibson-font-family is-style-outline--15" style="font-size:18px;font-style:normal;font-weight:500;text-decoration:none;text-transform:none"><a class="wp-block-button__link has-symeres-white-color has-symeres-secondary-background-color has-text-color has-background wp-element-button" href="https://admeshop.com/collections/biologics" style="border-radius:100px" target="_blank" rel="noopener"><strong>Request a quote via our Admeshop</strong></a></div> </div> <p></p> <section class="downloads downloadable-content-block"> <div class="downloads__list"> <form class="downloads"> <ul> <li> <input id="download-file-Admescope-Released-N-glycan-profiling-factsheet.pdf" name="download" data-filetitle="Admescope Released-N-glycan profiling factsheet" data-filename="Admescope-Released-N-glycan-profiling-factsheet.pdf" data-download="2786" name="download-file" type="checkbox"> <label for="download-file-Admescope-Released-N-glycan-profiling-factsheet.pdf"> Admescope Released-N-glycan profiling factsheet <span> <svg class="downloads-unchecked"><use xlink:href="#downloads-checkbox-default"></use></svg> <svg class="downloads-checked"><use xlink:href="#downloads-checkbox-checked"></use></svg> </span> </label> </li> </ul> </form> </div> </section> <h2 class="wp-block-heading"><span class="ez-toc-section" id="Biomolecular_Interactions"></span><strong>Biomolecular Interactions</strong><span class="ez-toc-section-end"></span></h2> <p class="has-medium-font-size">Surface plasmon resonance (SPR) and bio-layer interferometry (BLI) are label-free techniques which are used to investigate biomolecular interactions. They are especially suitable for characterizing antibody-antigen interactions and Fc-related antibody-effector interactions. In these techniques, the ligand is captured on the biosensor surface and binding of the analyte is investigated and information on the association and dissociation kinetics is obtained.</p> <figure class="wp-block-image alignleft size-full"><img loading="lazy" decoding="async" width="261" height="297" src="https://www.admescope.com/wp-content/uploads/sites/2/2023/05/biologics-5-1-1.png" alt="Admescope Biomolecular Interactions services" class="wp-image-990" /></figure> <p class="has-medium-font-size">We provide SPR and BLI analyses to characterize protein-protein (e.g., antibody-antigen), antibody – FcRn and antibody – FcγR interactions. While measurements for ranking of antibody candidates can be done using single concentrations, determination of the kinetic parameters typically requires analysis using multiple concentrations. When investigating antibody – FcRn receptor interactions, the binding is studied at two different pH conditions, which are relevant for antibody recycling. For investigating FcRn interactions, receptors of various preclinical species and human are available. For FcγR-related interactions, we provide analysis of mAb binding affinity on human FcγRI, FcγRIIA (H/R131), FcγRIIB, FcγRIIIA (V/F158) and FcγRIIIB.</p> <p></p> <div class="wp-block-buttons is-content-justification-left is-layout-flex wp-container-core-buttons-is-layout-16 wp-block-buttons-is-layout-flex"> <div class="wp-block-button has-custom-font-size is-style-outline has-gibson-font-family is-style-outline--16" style="font-size:18px;font-style:normal;font-weight:500;text-decoration:none;text-transform:none"><a class="wp-block-button__link has-symeres-white-color has-symeres-secondary-background-color has-text-color has-background wp-element-button" href="https://admeshop.com/collections/biologics" style="border-radius:100px" target="_blank" rel="noopener"><strong>Request a quote via our Admeshop</strong></a></div> </div> <p></p> <section class="downloads downloadable-content-block"> <div class="downloads__list"> <form class="downloads"> <ul> <li> <input id="download-file-Admescope-Biomolecular-interactions-factsheet.pdf" name="download" data-filetitle="Admescope Biomolecular interactions factsheet" data-filename="Admescope-Biomolecular-interactions-factsheet.pdf" data-download="2750" name="download-file" type="checkbox"> <label for="download-file-Admescope-Biomolecular-interactions-factsheet.pdf"> Admescope Biomolecular interactions factsheet <span> <svg class="downloads-unchecked"><use xlink:href="#downloads-checkbox-default"></use></svg> <svg class="downloads-checked"><use xlink:href="#downloads-checkbox-checked"></use></svg> </span> </label> </li> </ul> </form> </div> </section> <div style="height:25px" aria-hidden="true" class="wp-block-spacer"></div> </div></div> <section class="block block--primary"> <div class="block__content block__content--right"> <div class="block__text"> <h2>Feel free to contact us!</h2> <p><strong>Curious to know more about what can we do for you? 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name="email" type="email" placeholder="Email" required> </div> </div> <div class="form__row"> <div class="form__col"> <label for="agreement"> <input id="agreement" name="agreement" type="checkbox" required> <div>By downloading, I agree to the <a href='/privacy-policy/'>privacy policy</a></div> </label> </div> </div> <div class="form__row"> <div class="form__col"> <input type="text" name="downloaded_files" value="" style="opacity: 0;height: 0;overflow: hidden;"> <button type="submit" class="button button--primary">Download file(s)</button> <input type="hidden" name="action" value="symeresdownloads"> </div> </div> </form> </div> </section><script> jQuery( document ).ready(function() { jQuery(function ($) { let downloads = {}; $('body').on('click', '#downloads-close', function(){ $('.downloads__label').css('display', 'flex'); $('.downloads__content').css('display', 'none'); }); $('body').on('click', '.downloads__label', function(){ $('.downloads__label').css('display', 'none'); $('.downloads__content').css('display', 'flex'); }); $('body').on('change', 'form.downloads', function(){ let downloadsList = ''; let filenames = {}; $('input:checkbox[name=download]').each(function(){ filenames[$(this).data('filename')] = $(this).data('filetitle'); if (this.checked) { downloads[$(this).data('download')] = $(this).data('filename'); } else { if ($(this).data('download') in downloads) { delete downloads[$(this).data('download')]; } if (localStorage.getItem('downloads')) { let downloadsFromLocalStorage = JSON.parse(localStorage.getItem('downloads')); if ($(this).data('download') in downloadsFromLocalStorage) { delete downloadsFromLocalStorage[$(this).data('download')]; localStorage.setItem('downloads', JSON.stringify(downloadsFromLocalStorage)); } } } $('input[name="downloaded_files"]').val(Object.values(filenames).join(',')); }); // set filenames + titles in localStorage if (Object.keys(filenames).length) { let filenamesJson = JSON.stringify(filenames); if (localStorage.getItem('filenames')) { let currentFilenames = JSON.parse(localStorage.getItem('filenames')); filenames = { ...currentFilenames, ...filenames }; filenamesJson = JSON.stringify(filenames); } localStorage.setItem('filenames', filenamesJson); } if (Object.keys(downloads).length) { $('.downloads__aside').css('display', 'block'); let downloadsJson = JSON.stringify(downloads); if (localStorage.getItem('downloads')) { let currentDownloads = JSON.parse(localStorage.getItem('downloads')); downloads = { ...currentDownloads, ...downloads }; downloadsJson = JSON.stringify(downloads); } localStorage.setItem('downloads', downloadsJson); } else { if (!localStorage.getItem('downloads')) { localStorage.removeItem('downloads'); } } Object.keys(downloads).forEach(key => { let label = $('.downloads li label[for="download-file-' + downloads[key] + '"]').text(); if (localStorage.getItem('downloads')) { let downloadsFromLocalStorage = JSON.parse(localStorage.getItem('downloads')); if (localStorage.getItem('filenames')) { let filenames = JSON.parse(localStorage.getItem('filenames')); if (downloadsFromLocalStorage[key] in filenames) { label = filenames[downloadsFromLocalStorage[key]]; } } if (label === '') { label = $('.downloads li label[for="download-file-' + downloadsFromLocalStorage[key] + '"]').text(); } } downloadsList += '<li><button data-download="' + key + '"><svg class="downloads__delete"><use xlink:href="#icon-times"></use></svg></button><span><svg class="downloads__icon"><use xlink:href="#icon-download-file"></use></svg></span>' + label.trim() + '</li>'; }); $('.downloads__label span').text(Object.keys(downloads).length); $('#selected-files ul').html(downloadsList); // if (Object.keys(downloads).length) { //if (localStorage.getItem('downloads')) { // $('.downloads__aside').css('display', 'block'); // } else { // $('.downloads__aside').css('display', 'none'); // } }); if (localStorage.getItem('downloads')) { let downloadsFromLocalStorage = JSON.parse(localStorage.getItem('downloads')); let downloadsList = ''; $("input[name='downloaded_files']").val(Object.values(downloadsFromLocalStorage).join(',')); Object.keys(downloadsFromLocalStorage).forEach(key => { $(".downloads ul").find("[data-filename='" + downloadsFromLocalStorage[key] + "']").prop('checked', true); let label = ''; if (localStorage.getItem('filenames')) { let filenames = JSON.parse(localStorage.getItem('filenames')); if (downloadsFromLocalStorage[key] in filenames) { label = filenames[downloadsFromLocalStorage[key]]; } } if (label === '') { label = $('.downloads li label[for="download-file-' + downloadsFromLocalStorage[key] + '"]').text(); } downloadsList += '<li><button data-download="' + key + '"><svg class="downloads__delete"><use xlink:href="#icon-times"></use></svg></button><span><svg class="downloads__icon"><use xlink:href="#icon-download-file"></use></svg></span>' + label.trim() + '</li>'; }); $('.downloads__label span').text(Object.keys(downloadsFromLocalStorage).length); $('#selected-files ul').html(downloadsList); $('.downloads__aside').css('display', 'block'); } else { $('.downloads__aside').css('display', 'none'); } $('body').on('click', '#remove-all-files', function(){ localStorage.removeItem('downloads'); $('#selected-files div ul li').remove(); $('.downloads__aside').css('display', 'none'); location.reload(); }); $('body').on('click', '#selected-files button', function(){ $('form.downloads input[data-download=' + $(this).data('download') + ']').prop('checked', false).trigger('change'); if (localStorage.getItem('downloads')) { let downloadsLocalObj = JSON.parse(localStorage.getItem('downloads')); if ($(this).data('download') in downloadsLocalObj) { delete downloadsLocalObj[$(this).data('download')]; localStorage.setItem('downloads', JSON.stringify(downloadsLocalObj)); //reload sidebar html let downloadsList = ''; Object.keys(downloadsLocalObj).forEach(key => { $(".downloads ul").find("[data-filename='" + downloadsLocalObj[key] + "']").prop('checked', true); let label = ''; if (localStorage.getItem('filenames')) { let filenames = JSON.parse(localStorage.getItem('filenames')); if (downloadsLocalObj[key] in filenames) { label = filenames[downloadsLocalObj[key]]; } } if (label === '') { label = $('.downloads li label[for="download-file-' + downloadsLocalObj[key] + '"]').text(); } downloadsList += '<li><button data-download="' + key + '"><svg class="downloads__delete"><use xlink:href="#icon-times"></use></svg></button><span><svg class="downloads__icon"><use xlink:href="#icon-download-file"></use></svg></span>' + label.trim() + '</li>'; }); $('.downloads__label span').text(Object.keys(downloadsLocalObj).length); $('#selected-files ul').html(downloadsList); $('.downloads__aside').css('display', 'block'); } } }); $('#symeresdownloads').on('submit', function (e) { e.preventDefault(); if (localStorage.getItem('downloads')) { downloads = JSON.parse(localStorage.getItem('downloads')); $("input[name='downloaded_files']").val(''); $("input[name='downloaded_files']").val(Object.values(downloads).join(',')); } var symeresdownloads = $('#symeresdownloads'); var email = $("#symeresdownloads :input[name='email']").val(); var firstName = $("#symeresdownloads :input[name='first-name']").val(); var lastName = $("#symeresdownloads :input[name='last-name']").val(); var company = $("#symeresdownloads :input[name='company']").val(); var action = $("#symeresdownloads :input[name='action']").val(); downloads['email'] = email; downloads['first-name'] = firstName; downloads['last-name'] = lastName; downloads['company'] = company; downloads['action'] = action; runAjaxCall(symeresdownloads, downloads); // Clean up the downloads object delete downloads['email']; delete downloads['first-name']; delete downloads['last-name']; delete downloads['company']; delete downloads['action']; e.preventDefault(); }); function runAjaxCall(symeresdownloads, downloads) { var array = Object.keys(downloads).map((key) => [String(key), downloads[key]]); $.ajax({ url: symeresdownloads.attr('action'), data: downloads, // form data type: symeresdownloads.attr('method'), // POST beforeSend: function (xhr) { jQuery('#symeresdownloads button').hide(); jQuery('<p class="download-status">Your file(s) are being processed.</p>').insertAfter('#symeresdownloads button'); }, success: function (data) { let error = false; if (data.includes('address') || data.includes('download')) { if (!data.includes('Thank you')) { error = true; jQuery('.download-status').remove(); jQuery('.downloads__content').append('<div class="status-msg" style="font-weight:500; color: #FFF;">' + data + '</div>') } } if (data.includes('Thank you')) { error = false; jQuery('.download-status').remove(); jQuery('.downloads__content').append('<div class="status-msg" style="font-weight:500; color: #FFF;">' + data + '</div>') } setTimeout(function(){ jQuery('.status-msg').remove(); if (error) { jQuery('input#email').css('border-color', '#d63637'); location.reload(); } if (!error) { localStorage.removeItem('downloads'); $('.downloads__aside').css('display', 'none'); location.reload(); } }, 5000); } }); } if ($('.downloads__label span').text() == '0') { $('.downloads__aside').css('display', 'none'); } $('body').on('change', '.downloads__label span', function(){ if ($('.downloads__label span').text() == '0') { $('.downloads__aside').css('display', 'none'); } }); }); }); </script><script id="wp-block-template-skip-link-js-after"> ( function() { var skipLinkTarget = document.querySelector( 'main' ), sibling, skipLinkTargetID, skipLink; // Early exit if a skip-link target can't be located. if ( ! skipLinkTarget ) { return; } /* * Get the site wrapper. * The skip-link will be injected in the beginning of it. */ sibling = document.querySelector( '.wp-site-blocks' ); // Early exit if the root element was not found. if ( ! sibling ) { 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