Does Bladder Cancer Pathology Matter in Prognosis and Treatment?

<!DOCTYPE html> <html lang="en" class="no-js">  <head> <meta charset="utf-8"/> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="robots" content="all"/> <title>Does Bladder Cancer Pathology Matter in Prognosis and Treatment? | SciTechnol</title> <meta name="keywords" content="Neuroendocrine tumors; Metastatic; Small cell carcinoma; Bladder cancer, scitechnol, SciTechnol, subscription journals, International Publisher, International Publishers, Publisher of Science, Publisher of Technology, Publisher of Medicine"> <meta name="description" content="Context: Neuroendocrine tumors of the bladder are rare, accounting for 0.35- 0.7% of all bladder cancers. Small cell carcinoma of the bladder is a type of neuroendocrine .."> <meta name="citation_journal_title" content="Journal of Clinical & Experimental Oncology"> <meta name="citation_publisher" content="SciTechnol"/> <meta name="citation_author" content="Mohamad El Abdallah"/> <meta name="citation_author" content="Ahmed Ali"/> <meta name="citation_author" content="Isra Ibrahim"/> <meta name="citation_author" content="Faisal Musa"/> <meta name="citation_author" content="Rajiv John"/> <meta name="citation_author" content="Beaumont Hospital- Dearborn"/> <meta name="citation_title" content="Does Bladder Cancer Pathology Matter in Prognosis and Treatment?"> <meta name="citation_volume" content="2018"/> <meta name="citation_date" content="2018-04-17"/> <meta name="citation_year" content="2018"/> <meta name="citation_doi" content="10.4172/2324-9110.1000217"/> <meta name="citation_issn" content="2324-9110"/> <meta name="citation_abstract" content="Context: Neuroendocrine tumors of the bladder are rare, accounting for 0.35- 0.7% of all bladder cancers. Small cell carcinoma of the bladder is a type of neuroendocrine tumor, and it accounts for 0.5- 1% of all tumors of the bladder in some reports, and 0.53% other reports. It is a highly aggressive tumor that presents with nonspecific symptoms. Overall survival of non-metastatic disease is estimated to be about 20.7 month. The survival rate becomes much lower in metastatic disease, with 1-year survival rate about 30%. Case Report: A 74-year-old ex- smoker male patient presents to the hospital with the chronic complaint of back pain, and a new complaint of urine retention and dark urine. Lumbar spine MRI showed extensive vertebral metastasis and spinal canal stenosis. Cystoscopy showed a large bladder tumor with evident muscle invasion (clinical T3 stage by cystoscopy). Further evaluation showed liver, osseous, adrenal and retroperitoneal metastasis in addition to diffuse bony involvement. The patient received palliative radiotherapy in addition to 4 cycles of chemotherapy (carboplatin- etoposide) with subsequent progression. The patient was planned to start Nivolumab immunotherapy, however, he passed away before that. Conclusion: SCCB is a highly malignant NET, usually presenting with symptoms suggestive of advanced disease. Bad prognostic factors include age >60 ears, metastatic disease, local vascular and perineural invasion. Clinical trials addressing specifically SCCB and its treatment are rare. SCCB is often treated according to small cell lung cancer guidelines with platinum-based and etoposide chemotherapy, with poor outcomes in metastatic disease. Some clinicians consider immunotherapy with (Nivolumab) as a last resort in addition to palliative radiotherapy."/>  <style> .img-responsive { cursor:pointer; } </style> <script type="text/javascript"> function popup(theURL,winName,features) { window.open(theURL,winName,features); } function openimage(theURL,winName,features) { window.open(theURL,winName,features); } </script> <script type="text/javascript"> function popup(theURL,winName,features) { window.open(theURL,winName,features); } function registerhere() { var articleurl=escape(document.location.href); var articletitle=document.title; articletitle=articletitle.replace(" ", ""); window.open("https://www.scitechnol.com/user-registration.php?articletitle="+articletitle+"&articleurl="+articleurl,"_self"); } </script>  <script src="https://ajax.googleapis.com/ajax/libs/jquery/3.2.1/jquery.min.js"></script> <script language="javascript"> $(document).ready(function() { $("#ft_login_form").submit(function(e) { e.preventDefault(); 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Authors are requested to submit articles directly to <a href="https://www.scholarscentral.org/submissions/clinical-experimental-oncology.html" target="_blank" class="text-warning"><strong>Online Manuscript Submission System</strong></a> of respective journal. </div> </div> </div>  <div class="bg-color-sky-light"> <div class="content container"> <div class="row"> <div class="col-md-9 md-margin-b-30"> <article class="blog-grid margin-b-30"> <div class="blog-grid-content full-text color-black"> <p class="volume-issue">Case Report, J Clin Exp Oncol Vol: 7 Issue: 2 </p> <h1>Does Bladder Cancer Pathology Matter in Prognosis and Treatment?</h1> <div><p><strong>Mohamad El Abdallah<sup><a href="#corr">*</a></sup>, Ahmed Ali, Isra Ibrahim, Faisal Musa, Rajiv John and Beaumont Hospital- Dearborn</strong></p> <p>Beaumont Hospital-Dearborn Campus, USA</p> <p><strong>*Corresponding Author :</strong> <strong>Mohamad El Abdallah<a name="corr"></a></strong> <br />Beaumont Hospital-Dearborn Campus, USA <strong><br />Tel: </strong>(313) 593-7000 <br /><strong>E-mail:</strong> Mohamad.ElAbdallah@beaumont.org</p> <p><strong>Received:</strong> January 25, 2018 <strong>Accepted:</strong> February 19, 2018 <strong>Published:</strong> February 26, 2018</p> <p><strong>Citation:</strong> <em>Abdallah ME, Ali A, Musa F, John R (2018) Does Bladder Cancer Pathology Matter in Prognosis and Treatment?. J Clin Exp Oncol 7:2. doi: 10.4172/2324-9110.1000217</em></p></div> <p> </p> <h2>Abstract</h2> <div><p style="text-align: justify;"><strong>Context:</strong> Neuroendocrine tumors of the bladder are rare, accounting for 0.35- 0.7% of all bladder cancers. Small cell carcinoma of the bladder is a type of neuroendocrine tumor, and it accounts for 0.5- 1% of all tumors of the bladder in some reports, and 0.53% other reports. It is a highly aggressive tumor that presents with nonspecific symptoms. Overall survival of non-metastatic disease is estimated to be about 20.7 month. The survival rate becomes much lower in metastatic disease, with 1-year survival rate about 30%.</p> <p style="text-align: justify;"><strong>Case Report:</strong> A 74-year-old ex- smoker male patient presents to the hospital with the chronic complaint of back pain, and a new complaint of urine retention and dark urine. Lumbar spine MRI showed extensive vertebral metastasis and spinal canal stenosis. Cystoscopy showed a large bladder tumor with evident muscle invasion (clinical T3 stage by cystoscopy). Further evaluation showed liver, osseous, adrenal and retroperitoneal metastasis in addition to diffuse bony involvement.</p> <p style="text-align: justify;">The patient received palliative radiotherapy in addition to 4 cycles of chemotherapy (carboplatin- etoposide) with subsequent progression. The patient was planned to start Nivolumab immunotherapy, however, he passed away before that.</p> <p style="text-align: justify;"><strong>Conclusion:</strong> SCCB is a highly malignant NET, usually presenting with symptoms suggestive of advanced disease. Bad prognostic factors include age >60 ears, metastatic disease, local vascular and perineural invasion. Clinical trials addressing specifically SCCB and its treatment are rare. SCCB is often treated according to small cell lung cancer guidelines with platinum-based and etoposide chemotherapy, with poor outcomes in metastatic disease. Some clinicians consider immunotherapy with (Nivolumab) as a last resort in addition to palliative radiotherapy.</p></div> <h3>Keywords: <span class="font-size-15 fweight-300">Neuroendocrine tumors; Metastatic; Small cell carcinoma; Bladder cancer</span></h3> <div> <section class="newsletter-v2 bg-color-dark-light padding-30 radius-10"> <div class="row"> <div class="col-sm-7 sm-margin-b-50"> <h3 class="newsletter-v2-title">Subscription required</h3> <span class="newsletter-v2-author">Please login to access the full article, or register if you do not yet have an account</span><hr> <span class="newsletter-v2-author">Not yet a registered user? 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