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NICHD Fragile X Syndrome Research Information | NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development
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type="button" > <span>Cerebral Palsy</span> </button> <ul id="basic-mobile-nav-section-CerebralPalsy" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/cerebral-palsy" class="parent-link"> <span>Cerebral Palsy</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/cerebral-palsy/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/cerebral-palsy/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/cerebral-palsy/findastudy"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/cerebral-palsy/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-CongenitalAdrenalHyperplasia(CAH)" type="button" > <span>Congenital Adrenal Hyperplasia (CAH)</span> </button> <ul id="basic-mobile-nav-section-CongenitalAdrenalHyperplasia(CAH)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/cah" class="parent-link"> <span>Congenital Adrenal Hyperplasia (CAH)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/cah/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/cah/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/cah/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/cah/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-CongenitalAnomalies" type="button" > <span>Congenital Anomalies</span> </button> <ul id="basic-mobile-nav-section-CongenitalAnomalies" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/congenital-anomalies" class="parent-link"> <span>Congenital Anomalies</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/congenital-anomalies/about"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/congenital-anomalies/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/congenital-anomalies/findastudy"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/congenital-anomalies/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-ContraceptionandBirthControl" type="button" > <span>Contraception and Birth Control</span> </button> <ul id="basic-mobile-nav-section-ContraceptionandBirthControl" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/contraception" class="parent-link"> <span>Contraception and Birth Control</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/contraception/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/contraception/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/contraception/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/contraception/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-CushingSyndrome" type="button" > <span>Cushing Syndrome</span> </button> <ul id="basic-mobile-nav-section-CushingSyndrome" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/cushing" class="parent-link"> <span>Cushing Syndrome</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/cushing/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/cushing/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/cushing/findastudy"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/cushing/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Diabetes" type="button" > <span>Diabetes</span> </button> <ul id="basic-mobile-nav-section-Diabetes" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/diabetes" class="parent-link"> <span>Diabetes</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/diabetes/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/diabetes/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/diabetes/findastudy"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/diabetes/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-DownSyndrome" type="button" > <span>Down Syndrome</span> </button> <ul id="basic-mobile-nav-section-DownSyndrome" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/downsyndrome" class="parent-link"> <span>Down Syndrome</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/down/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/down/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/down/findastudy"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/down/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-DrivingRisk" type="button" > <span>Driving Risk</span> </button> <ul id="basic-mobile-nav-section-DrivingRisk" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/drivingrisk" class="parent-link"> <span>Driving Risk</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/driving/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/driving/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/driving/findastudy"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/driving/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-EarlyLearning" type="button" > <span>Early Learning</span> </button> <ul id="basic-mobile-nav-section-EarlyLearning" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/early-learning" class="parent-link"> <span>Early Learning</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/early-learning/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/early-learning/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/early-learning/findastudy"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/early-learning/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Endometriosis" type="button" > <span>Endometriosis</span> </button> <ul id="basic-mobile-nav-section-Endometriosis" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/endometriosis" class="parent-link"> <span>Endometriosis</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/endometri/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/endometri/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/endometri/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/endometri/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button usa-current" aria-expanded="true" aria-controls="basic-mobile-nav-section-FragileXSyndrome" type="button" > <span>Fragile X Syndrome</span> </button> <ul id="basic-mobile-nav-section-FragileXSyndrome" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/fragilex" class="parent-link"> <span>Fragile X Syndrome</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/fragilex/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/fragilex/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/fragilex/findastudy"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/fragilex/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-FragileX-AssociatedPrimaryOvarianInsufficiency(FXPOI)" type="button" > <span>Fragile X-Associated Primary Ovarian Insufficiency (FXPOI)</span> </button> <ul id="basic-mobile-nav-section-FragileX-AssociatedPrimaryOvarianInsufficiency(FXPOI)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/fxpoi" class="parent-link"> <span>Fragile X-Associated Primary Ovarian Insufficiency (FXPOI)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/fxpoi/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/fxpoi/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/fxpoi/findastudy"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/fxpoi/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-FragileX-AssociatedTremorandAtaxiaSyndrome(FXTAS)" type="button" > <span>Fragile X-Associated Tremor and Ataxia Syndrome (FXTAS)</span> </button> <ul id="basic-mobile-nav-section-FragileX-AssociatedTremorandAtaxiaSyndrome(FXTAS)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/fxtas" class="parent-link"> <span>Fragile X-Associated Tremor and Ataxia Syndrome (FXTAS)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/fxtas/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/fxtas/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/fxtas/findastudy"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/fxtas/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-HIV/AIDS" type="button" > <span>HIV/AIDS</span> </button> <ul id="basic-mobile-nav-section-HIV/AIDS" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/hiv" class="parent-link"> <span>HIV/AIDS</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/hiv/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/hiv/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/hiv/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/hiv/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-High-RiskPregnancy" type="button" > <span>High-Risk Pregnancy</span> </button> <ul id="basic-mobile-nav-section-High-RiskPregnancy" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/high-risk" class="parent-link"> <span>High-Risk Pregnancy</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/high-risk/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/high-risk/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/high-risk/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/high-risk/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Hypoparathyroidism" type="button" > <span>Hypoparathyroidism</span> </button> <ul id="basic-mobile-nav-section-Hypoparathyroidism" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/hypopara" class="parent-link"> <span>Hypoparathyroidism</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/hypopara/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/hypopara/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/hypopara/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/hypopara/resources/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-InfantCareandInfantHealth" type="button" > <span>Infant Care and Infant Health</span> </button> <ul id="basic-mobile-nav-section-InfantCareandInfantHealth" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/infantcare" class="parent-link"> <span>Infant Care and Infant Health</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/infantcare/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/infantcare/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/infantcare/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/infantcare/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-InfantMortality" type="button" > <span>Infant Mortality</span> </button> <ul id="basic-mobile-nav-section-InfantMortality" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/infant-mortality" class="parent-link"> <span>Infant Mortality</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/infant-mortality/topicinfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/infant-mortality/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/infant-mortality/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/infant-mortality/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-InfertilityandFertility" type="button" > <span>Infertility and Fertility</span> </button> <ul id="basic-mobile-nav-section-InfertilityandFertility" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/infertility" class="parent-link"> <span>Infertility and Fertility</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/infertility/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/infertility/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/infertility/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/infertility/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-IntellectualandDevelopmentalDisabilities(IDDs)" type="button" > <span>Intellectual and Developmental Disabilities (IDDs)</span> </button> <ul id="basic-mobile-nav-section-IntellectualandDevelopmentalDisabilities(IDDs)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/idds" class="parent-link"> <span>Intellectual and Developmental Disabilities (IDDs)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/idds/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/idds/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/idds/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/idds/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-KlinefelterSyndrome(KS)" type="button" > <span>Klinefelter Syndrome (KS)</span> </button> <ul id="basic-mobile-nav-section-KlinefelterSyndrome(KS)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/klinefelter" class="parent-link"> <span>Klinefelter Syndrome (KS)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/klinefelter/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/klinefelter/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/klinefelter/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/klinefelter/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-LaborandDelivery" type="button" > <span>Labor and Delivery</span> </button> <ul id="basic-mobile-nav-section-LaborandDelivery" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/labor-delivery" class="parent-link"> <span>Labor and Delivery</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/labor-delivery/topicinfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/labor-delivery/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/labor-delivery/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/labor-delivery/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-LearningDisabilities" type="button" > <span>Learning Disabilities</span> </button> <ul id="basic-mobile-nav-section-LearningDisabilities" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/learningdisabilities" class="parent-link"> <span>Learning Disabilities</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/learning/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/learning/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/learning/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/learning/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-MaternalMorbidityandMortality" type="button" > <span>Maternal Morbidity and Mortality</span> </button> <ul id="basic-mobile-nav-section-MaternalMorbidityandMortality" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/maternal-morbidity-mortality" class="parent-link"> <span>Maternal Morbidity and Mortality</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/maternal-morbidity-mortality/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/maternal-morbidity-mortality/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/maternal-morbidity-mortality/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/maternal-morbidity-mortality/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-McCune-AlbrightSyndrome(MAS)" type="button" > <span>McCune-Albright Syndrome (MAS)</span> </button> <ul id="basic-mobile-nav-section-McCune-AlbrightSyndrome(MAS)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/mccune-albright" class="parent-link"> <span>McCune-Albright Syndrome (MAS)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/mccune-albright/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/mccune-albright/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/mccune-albright/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/mccune-albright/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Men'sReproductiveHealth" type="button" > <span>Men's Reproductive Health</span> </button> <ul id="basic-mobile-nav-section-Men'sReproductiveHealth" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/menshealth" class="parent-link"> <span>Men's Reproductive Health</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/menshealth/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/menshealth/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/menshealth/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/menshealth/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Menopause" type="button" > <span>Menopause</span> </button> <ul id="basic-mobile-nav-section-Menopause" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/menopause" class="parent-link"> <span>Menopause</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/menopause/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/menopause/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/menopause/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/menopause/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-MenstruationandMenstrualProblems" type="button" > <span>Menstruation and Menstrual Problems</span> </button> <ul id="basic-mobile-nav-section-MenstruationandMenstrualProblems" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/menstruation" class="parent-link"> <span>Menstruation and Menstrual Problems</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/menstruation/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/menstruation/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/menstruation/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/menstruation/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-MuscularDystrophy" type="button" > <span>Muscular Dystrophy</span> </button> <ul id="basic-mobile-nav-section-MuscularDystrophy" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/musculardys" class="parent-link"> <span>Muscular Dystrophy</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/musculardys/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/musculardys/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/musculardys/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/musculardys/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-NecrotizingEnterocolitis(NEC)" type="button" > <span>Necrotizing Enterocolitis (NEC)</span> </button> <ul id="basic-mobile-nav-section-NecrotizingEnterocolitis(NEC)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/nec" class="parent-link"> <span>Necrotizing Enterocolitis (NEC)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/nec/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/nec/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/nec/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/nec/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-NeuralTubeDefects(NTDs)" type="button" > <span>Neural Tube Defects (NTDs)</span> </button> <ul id="basic-mobile-nav-section-NeuralTubeDefects(NTDs)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/ntds" class="parent-link"> <span>Neural Tube Defects (NTDs)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/ntds/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/ntds/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/ntds/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/ntds/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Neuroscience" type="button" > <span>Neuroscience</span> </button> <ul id="basic-mobile-nav-section-Neuroscience" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/neuro" class="parent-link"> <span>Neuroscience</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/neuro/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/neuro/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/neuro/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/neuro/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-NewbornScreening" type="button" > <span>Newborn Screening</span> </button> <ul id="basic-mobile-nav-section-NewbornScreening" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/newborn" class="parent-link"> <span>Newborn Screening</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/newborn/conditioninfo/default"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/newborn/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/newborn/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/newborn/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-ObesityandOverweight" type="button" > <span>Obesity and Overweight</span> </button> <ul id="basic-mobile-nav-section-ObesityandOverweight" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/obesity" class="parent-link"> <span>Obesity and Overweight</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/obesity/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/obesity/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/obesity/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/obesity/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-OsteogenesisImperfecta(OI)" type="button" > <span>Osteogenesis Imperfecta (OI)</span> </button> <ul id="basic-mobile-nav-section-OsteogenesisImperfecta(OI)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/osteogenesisimp" class="parent-link"> <span>Osteogenesis Imperfecta (OI)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/osteogenesisimp/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/osteogenesisimp/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/osteogenesisimp/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/osteogenesisimp/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-PediatricInjury" type="button" > <span>Pediatric Injury</span> </button> <ul id="basic-mobile-nav-section-PediatricInjury" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/pediatric" class="parent-link"> <span>Pediatric Injury</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pediatric/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pediatric/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pediatric/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pediatric/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-PelvicFloorDisorders" type="button" > <span>Pelvic Floor Disorders</span> </button> <ul id="basic-mobile-nav-section-PelvicFloorDisorders" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/pelvicfloor" class="parent-link"> <span>Pelvic Floor Disorders</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pelvicfloor/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pelvicfloor/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pelvicfloor/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pelvicfloor/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-PelvicPain" type="button" > <span>Pelvic Pain</span> </button> <ul id="basic-mobile-nav-section-PelvicPain" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/pelvicpain" class="parent-link"> <span>Pelvic Pain</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pelvicpain/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pelvicpain/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pelvicpain/clinicaltrials/default"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pelvicpain/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Pharmacology" type="button" > <span>Pharmacology</span> </button> <ul id="basic-mobile-nav-section-Pharmacology" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/pharma" class="parent-link"> <span>Pharmacology</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pharma/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pharma/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pharma/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pharma/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Phenylketonuria(PKU)" type="button" > <span>Phenylketonuria (PKU)</span> </button> <ul id="basic-mobile-nav-section-Phenylketonuria(PKU)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/pku" class="parent-link"> <span>Phenylketonuria (PKU)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pku/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pku/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pku/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pku/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-PheochromocytomaandParaganglioma" type="button" > <span>Pheochromocytoma and Paraganglioma</span> </button> <ul id="basic-mobile-nav-section-PheochromocytomaandParaganglioma" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/pheochrom" class="parent-link"> <span>Pheochromocytoma and Paraganglioma</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pheochrom/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pheochrom/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pheochrom/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pheochrom/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-PituitaryTumors" type="button" > <span>Pituitary Tumors</span> </button> <ul id="basic-mobile-nav-section-PituitaryTumors" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/pituitarytumors" class="parent-link"> <span>Pituitary Tumors</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pituitarytumors/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pituitarytumors/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pituitarytumors/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pituitarytumors/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-PolycysticOvarySyndrome(PCOS)" type="button" > <span>Polycystic Ovary Syndrome (PCOS)</span> </button> <ul id="basic-mobile-nav-section-PolycysticOvarySyndrome(PCOS)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/pcos" class="parent-link"> <span>Polycystic Ovary Syndrome (PCOS)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pcos/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pcos/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pcos/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pcos/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Prader-WilliSyndrome(PWS)" type="button" > <span>Prader-Willi Syndrome (PWS)</span> </button> <ul id="basic-mobile-nav-section-Prader-WilliSyndrome(PWS)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/prader-willi" class="parent-link"> <span>Prader-Willi Syndrome (PWS)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/prader-willi/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/prader-willi/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/prader-willi/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/prader-willi/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Pre-PregnancyCareandPrenatalCare" type="button" > <span>Pre-Pregnancy Care and Prenatal Care</span> </button> <ul id="basic-mobile-nav-section-Pre-PregnancyCareandPrenatalCare" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/preconceptioncare" class="parent-link"> <span>Pre-Pregnancy Care and Prenatal Care</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/preconceptioncare/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/preconceptioncare/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/preconceptioncare/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/preconceptioncare/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-PreeclampsiaandEclampsia" type="button" > <span>Preeclampsia and Eclampsia</span> </button> <ul id="basic-mobile-nav-section-PreeclampsiaandEclampsia" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/preeclampsia" class="parent-link"> <span>Preeclampsia and Eclampsia</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/preeclampsia/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/preeclampsia/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/preeclampsia/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/preeclampsia/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-PregnancyLoss" type="button" > <span>Pregnancy Loss</span> </button> <ul id="basic-mobile-nav-section-PregnancyLoss" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/pregnancyloss" class="parent-link"> <span>Pregnancy Loss</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pregnancyloss/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pregnancyloss/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pregnancyloss/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pregnancyloss/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Pregnancy" type="button" > <span>Pregnancy</span> </button> <ul id="basic-mobile-nav-section-Pregnancy" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/pregnancy" class="parent-link"> <span>Pregnancy</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pregnancy/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pregnancy/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pregnancy/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/pregnancy/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-PretermLaborandBirth" type="button" > <span>Preterm Labor and Birth</span> </button> <ul id="basic-mobile-nav-section-PretermLaborandBirth" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/preterm" class="parent-link"> <span>Preterm Labor and Birth</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/preterm/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/preterm/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/preterm/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/preterm/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-PrimaryOvarianInsufficiency(POI)" type="button" > <span>Primary Ovarian Insufficiency (POI)</span> </button> <ul id="basic-mobile-nav-section-PrimaryOvarianInsufficiency(POI)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/poi" class="parent-link"> <span>Primary Ovarian Insufficiency (POI)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/poi/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/poi/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/poi/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/poi/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-PubertyandPrecociousPuberty" type="button" > <span>Puberty and Precocious Puberty</span> </button> <ul id="basic-mobile-nav-section-PubertyandPrecociousPuberty" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/puberty" class="parent-link"> <span>Puberty and Precocious Puberty</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/puberty/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/puberty/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/puberty/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/puberty/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-ReadingandReadingDisorders" type="button" > <span>Reading and Reading Disorders</span> </button> <ul id="basic-mobile-nav-section-ReadingandReadingDisorders" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/reading" class="parent-link"> <span>Reading and Reading Disorders</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/reading/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/reading/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/reading/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/reading/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-RehabilitationMedicine" type="button" > <span>Rehabilitation Medicine</span> </button> <ul id="basic-mobile-nav-section-RehabilitationMedicine" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/rehabilitation-medicine" class="parent-link"> <span>Rehabilitation Medicine</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/rehabilitation-medicine/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/rehabilitation-medicine/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/rehabilitation-medicine/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/rehabilitation-medicine/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-RehabilitativeandAssistiveTechnology" type="button" > <span>Rehabilitative and Assistive Technology</span> </button> <ul id="basic-mobile-nav-section-RehabilitativeandAssistiveTechnology" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/rehabtech" class="parent-link"> <span>Rehabilitative and Assistive Technology</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/rehabtech/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/rehabtech/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/rehabtech/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/rehabtech/resources"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <a href="/health/topics/reproductivehealth"> <span>Reproductive Health</span> </a> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-RettSyndrome" type="button" > <span>Rett Syndrome</span> </button> <ul id="basic-mobile-nav-section-RettSyndrome" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/rett" class="parent-link"> <span>Rett Syndrome</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/rett/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/rett/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/rett/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/rett/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-SexuallyTransmittedDiseases(STDs)" type="button" > <span>Sexually Transmitted Diseases (STDs)</span> </button> <ul id="basic-mobile-nav-section-SexuallyTransmittedDiseases(STDs)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/stds" class="parent-link"> <span>Sexually Transmitted Diseases (STDs)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/stds/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/stds/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/stds/clinicaltrials/default"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/stds/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Sleep" type="button" > <span>Sleep</span> </button> <ul id="basic-mobile-nav-section-Sleep" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/sleep" class="parent-link"> <span>Sleep</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/sleep/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/sleep/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/sleep/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/sleep/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-SpinaBifida" type="button" > <span>Spina Bifida</span> </button> <ul id="basic-mobile-nav-section-SpinaBifida" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/spinabifida" class="parent-link"> <span>Spina Bifida</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/spinabifida/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/spinabifida/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/spinabifida/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/spinabifida/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-SpinalCordInjury(SCI)" type="button" > <span>Spinal Cord Injury (SCI)</span> </button> <ul id="basic-mobile-nav-section-SpinalCordInjury(SCI)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/spinalinjury" class="parent-link"> <span>Spinal Cord Injury (SCI)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/spinalinjury/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/spinalinjury/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/spinalinjury/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/spinalinjury/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Stillbirth" type="button" > <span>Stillbirth</span> </button> <ul id="basic-mobile-nav-section-Stillbirth" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/stillbirth" class="parent-link"> <span>Stillbirth</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/stillbirth/topicinfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/stillbirth/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/stillbirth/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/stillbirth/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Stroke" type="button" > <span>Stroke</span> </button> <ul id="basic-mobile-nav-section-Stroke" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/stroke" class="parent-link"> <span>Stroke</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/stroke/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/stroke/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/stroke/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/stroke/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-SuddenInfantDeathSyndrome(SIDS)" type="button" > <span>Sudden Infant Death Syndrome (SIDS)</span> </button> <ul id="basic-mobile-nav-section-SuddenInfantDeathSyndrome(SIDS)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/sids" class="parent-link"> <span>Sudden Infant Death Syndrome (SIDS)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/sids/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/sids/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/sids/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/sids/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-TraumaticBrainInjury(TBI)" type="button" > <span>Traumatic Brain Injury (TBI)</span> </button> <ul id="basic-mobile-nav-section-TraumaticBrainInjury(TBI)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/tbi" class="parent-link"> <span>Traumatic Brain Injury (TBI)</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/tbi/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/tbi/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/tbi/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/tbi/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-TurnerSyndrome" type="button" > <span>Turner Syndrome</span> </button> <ul id="basic-mobile-nav-section-TurnerSyndrome" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/turner" class="parent-link"> <span>Turner Syndrome</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/turner/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/turner/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/turner/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/turner/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-UrinaryTractHealth" type="button" > <span>Urinary Tract Health</span> </button> <ul id="basic-mobile-nav-section-UrinaryTractHealth" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/urinary" class="parent-link"> <span>Urinary Tract Health</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/urinary/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/urinary/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/urinary/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/urinary/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-UterineFibroids" type="button" > <span>Uterine Fibroids</span> </button> <ul id="basic-mobile-nav-section-UterineFibroids" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/uterine" class="parent-link"> <span>Uterine Fibroids</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/uterine/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/uterine/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/uterine/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/uterine/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Vaginitis" type="button" > <span>Vaginitis</span> </button> <ul id="basic-mobile-nav-section-Vaginitis" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/vaginitis" class="parent-link"> <span>Vaginitis</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/vaginitis/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/vaginitis/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/vaginitis/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/vaginitis/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Vasectomy" type="button" > <span>Vasectomy</span> </button> <ul id="basic-mobile-nav-section-Vasectomy" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/vasectomy" class="parent-link"> <span>Vasectomy</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/vasectomy/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/vasectomy/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/vasectomy/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/vasectomy/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Vulvodynia" type="button" > <span>Vulvodynia</span> </button> <ul id="basic-mobile-nav-section-Vulvodynia" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/topics/vulvodynia" class="parent-link"> <span>Vulvodynia</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/vulvodynia/conditioninfo"> <span>About</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/vulvodynia/researchinfo"> <span>NICHD Research Information</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/vulvodynia/clinicaltrials"> <span>Find a Study</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/topics/vulvodynia/more_information"> <span>More Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <a href="/health/topics/womenshealth"> <span>Women's Health</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <a href="https://www.nichd.nih.gov/sts"> <span>Safe to Sleep® Campaign</span> </a> </li> <li class="mobile-menu-link"> <a href="https://www.nichd.nih.gov/ncmhep"> <span>National Child and Maternal Health Education Program</span> </a> </li> <li class="mobile-menu-link"> <a href="/publications"> <span>Find Publications</span> </a> </li> <li class="mobile-menu-link"> <a href="/caregivers"> <span>For Caregivers & Providers</span> </a> </li> <li class="mobile-menu-link"> <a href="https://extranet.nichd.nih.gov/nursececourse/Welcome.aspx"> <span>Take Continuing Education</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button " aria-expanded="false" aria-controls="basic-mobile-nav-section-Grants&Contracts" > <span>Grants & Contracts</span> </button> <ul id="basic-mobile-nav-section-Grants&Contracts" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/grants-contracts" class="parent-link"> <span>Grants & Contracts</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/research-areas/priorities"> <span>NICHD Research Priorities</span> </a> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" 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class="mobile-menu-link"> <a href="/grants-contracts/funding-opps-and-notices/active-nofos-notices" class="parent-link"> <span>Active Funding Opportunities and Notices for NICHD</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/funding-opps-and-notices/active-nofos-notices/parent"> <span>Parent Announcements (For Unsolicited or Investigator-Initiated Applications)</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/funding-opps-and-notices/funding-types"> <span>Types of NICHD Funding Mechanisms</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/funding-opps-and-notices/dissemination"> <span>NICHD Priorities for Dissemination and Implementation Research</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Contracts" type="button" > <span>Contracts</span> </button> <ul 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id="basic-mobile-nav-section-GrantsProcess,Policies&Strategies" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/grants-contracts/process-strategies" class="parent-link"> <span>Grants Process, Policies & Strategies</span> </a> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-GrantProcess" type="button" > <span>Grant Process</span> </button> <ul id="basic-mobile-nav-section-GrantProcess" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/grants-contracts/process-strategies/process" class="parent-link"> <span>Grant Process</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/process-strategies/process/overview"> <span>Overview</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/process-strategies/process/how-to-apply"> <span>How to Apply</span> </a> </li> <li 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href="/grants-contracts/process-strategies/contacts"> <span>NICHD Contacts for Funding Information</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/peer-review"> <span>Peer Review</span> </a> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-SmallBusinessPrograms" type="button" > <span>Small Business Programs</span> </button> <ul id="basic-mobile-nav-section-SmallBusinessPrograms" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR" class="parent-link"> <span>Small Business Programs</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/about"> <span>About the Programs</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/priorities"> <span>NICHD Priorities</span> </a> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-FundingOpportunities" type="button" > <span>Funding Opportunities</span> </button> <ul id="basic-mobile-nav-section-FundingOpportunities" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/funding" class="parent-link"> <span>Funding Opportunities</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/funding/targeted"> <span>Targeted Opportunities</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/types"> <span>Application Types</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/resources"> <span>Commercialization Resources</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/FAQs"> <span>FAQs</span> </a> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-SmallBusinessSuccessStories" type="button" > <span>Small Business Success Stories</span> </button> <ul id="basic-mobile-nav-section-SmallBusinessSuccessStories" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/showcase" class="parent-link"> <span>Small Business Success Stories</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/showcase/BioSensics"> <span>BioSensics™ – Wearable Sensors for Stroke Recovery and Chronic Disability Care</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/showcase/SEEKER"> <span>SEEKER® – The First FDA-Authorized Newborn Screening Platform for Lysosomal Storage Disorders</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/showcase/Simbex-HITS"> <span>Simbex Head Impact Telemetry System – Real-time Monitoring to Improve Safety in Sports</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/showcase/SpermCheck"> <span>SpermCheck® – FDA-Cleared Home Test for Male Fertility</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/showcase/bili-hut"> <span>bili-hut™ – FDA-Cleared Phototherapy for Treating Newborn Jaundice at Home</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/showcase/Elagolix"> <span>Elagolix – The First FDA-Approved Treatment for Endometriosis and Uterine Fibroids</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/showcase/Buzzy"> <span>Buzzy®—Pain Relief for Pediatric Vaccinations</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/SBIR_STTR/showcase/Miya-Model"> <span>Miya Model™ – Surgical Training Simulator for Obstetrician-Gynecologists (OB/GYNs)</span> </a> </li> </ul> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Training&CareerDevelopment" type="button" > <span>Training & Career Development</span> </button> <ul id="basic-mobile-nav-section-Training&CareerDevelopment" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/grants-contracts/training-careers" class="parent-link"> <span>Training & Career Development</span> </a> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-SupportforTrainingatUniversitiesandOtherInstitutions" type="button" > <span>Support for Training at Universities and Other Institutions</span> </button> <ul id="basic-mobile-nav-section-SupportforTrainingatUniversitiesandOtherInstitutions" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/grants-contracts/training-careers/extramural" class="parent-link"> <span>Support for Training at Universities and Other Institutions</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/training-careers/extramural/individual"> <span>Individual Research Fellowships (F)</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/training-careers/extramural/career"> <span>Career Development (K) Awards</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/training-careers/extramural/institutional"> <span>Institutional Training Grants (T32/K12)</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/training-careers/extramural/education"> <span>Education Grants (R25)</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/training-careers/extramural/FAQs"> <span>FAQs About Extramural Training</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-TrainingatNICHD" type="button" > <span>Training at NICHD</span> </button> <ul id="basic-mobile-nav-section-TrainingatNICHD" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/grants-contracts/training-careers/intramural" class="parent-link"> <span>Training at NICHD</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/training-careers/intramural/DIR"> <span>Training in the Division of Intramural Research (DIR)</span> </a> </li> <li class="mobile-menu-link"> <a href="/grants-contracts/training-careers/intramural/DiPHR"> <span>Training in the Division of Population Health Research (DiPHR)</span> </a> </li> </ul> </li> </ul> </li> <li class="mobile-menu-link"> <a href="/forapplicants"> <span>For Applicants</span> </a> </li> <li class="mobile-menu-link"> <a href="/clinicalresearchpoliciesredirect-grants"> <span>Clinical Research Policies</span> </a> </li> <li class="mobile-menu-link"> <a href="/sampleapplicationsredirect"> <span>Sample Applications</span> </a> </li> <li class="mobile-menu-link"> <a href="/sites/default/files/2017-12/Extramural_Res_Categories_Contacts.pdf"> <span>Find a Program Officer</span> </a> </li> <li class="mobile-menu-link"> <a href="https://grants.nih.gov/grants/forms.htm"> <span>Forms</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button " aria-expanded="false" aria-controls="basic-mobile-nav-section-ClinicalResearch" > <span>Clinical Research</span> </button> <ul id="basic-mobile-nav-section-ClinicalResearch" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/clinical-research" class="parent-link"> <span>Clinical Research</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/clinical-research#whatis"> <span>What Is Clinical Research?</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/clinical-research#find"> <span>Find NICHD Clinical Trials</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/clinical-research#clinicalcare"> <span>Where Can I Find Clinical Care Recommendations and Practice Guidelines?</span> </a> </li> <li class="mobile-menu-link"> <a href="/forresearchers"> <span>For Researchers</span> </a> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Pre-ApplicationProcessforNICHDNetworkMultisiteClinicalResearch" type="button" > <span>Pre-Application Process for NICHD Network Multisite Clinical Research</span> </button> <ul id="basic-mobile-nav-section-Pre-ApplicationProcessforNICHDNetworkMultisiteClinicalResearch" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/health/clinical-research/clinical-trial-preapplication-process" class="parent-link"> <span>Pre-Application Process for NICHD Network Multisite Clinical Research</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/clinical-research/clinical-trial-network-non-NICHD-funding"> <span>Network Projects that Use Non-NICHD Funding</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/clinical-research/clinical-trial-preapplication-process/concept-proposal"> <span>Concept Proposal Info</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/clinical-research/par-23-037-faqs"> <span>PAR-23-037 Frequently Asked Questions (FAQs)</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <a href="/clinicalresearchpoliciesredirect-clinical"> <span>Clinical Research Policies</span> </a> </li> <li class="mobile-menu-link"> <a href="/NICHDpolicies-clinical"> <span>NICHD Policies for Data & Safety Monitoring</span> </a> </li> <li class="mobile-menu-link"> <a href="/health/clinical-research/CSI-curriculum"> <span>Clinician-Scientist Investigator (CSI) Curriculum</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button " aria-expanded="false" aria-controls="basic-mobile-nav-section-Newsroom" > <span>Newsroom</span> </button> <ul id="basic-mobile-nav-section-Newsroom" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/newsroom" class="parent-link"> <span>Newsroom</span> </a> </li> <li class="mobile-menu-link"> <a href="/newsroom/news"> <span>News</span> </a> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-DigitalMedia" type="button" > <span>Digital Media</span> </button> <ul id="basic-mobile-nav-section-DigitalMedia" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/newsroom/digital-media" class="parent-link"> <span>Digital Media</span> </a> </li> <li class="mobile-menu-link"> <a href="/newsroom/digital-media/infographics"> <span>Infographics</span> </a> </li> <li class="mobile-menu-link"> <a href="/newsroom/digital-media/videos"> <span>Videos</span> </a> </li> <li class="mobile-menu-link"> <a href="/newsroom/digital-media/podcastsandaudio"> <span>Podcasts and Audio</span> </a> </li> <li class="mobile-menu-link"> <a href="/newsroom/digital-media/socialmedia"> <span>Social Media</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <a href="/newsroom/NICHDnews/index"> <span>Join NICHD Listservs</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button " aria-expanded="false" aria-controls="basic-mobile-nav-section-AboutNICHD" > <span>About NICHD</span> </button> <ul id="basic-mobile-nav-section-AboutNICHD" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/about" class="parent-link"> <span>About NICHD</span> </a> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-Organization" type="button" > <span>Organization</span> </button> <ul id="basic-mobile-nav-section-Organization" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/about/org" class="parent-link"> <span>Organization</span> </a> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-OfficeoftheDirector" type="button" > <span>Office of the Director</span> </button> <ul id="basic-mobile-nav-section-OfficeoftheDirector" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/about/org/od" class="parent-link"> <span>Office of the Director</span> </a> </li> <li class="mobile-menu-link"> <a href="/about/org/od/directors_corner"> <span>Director's Corner</span> </a> </li> <li class="mobile-menu-link"> <a href="/about/org/od/oam"> <span>Office of Administrative Management (OAM)</span> </a> </li> <li class="mobile-menu-link"> <a href="/about/org/od/oc"> <span>Office of Communications (OC)</span> </a> </li> <li class="mobile-menu-link"> <a href="/about/org/od/odss"> <span>Office of Data Science and Sharing (ODSS)</span> </a> </li> <li class="mobile-menu-link"> <a href="/about/org/od/ogh"> <span>Office of Global Health (OGH)</span> </a> </li> <li class="mobile-menu-link"> <a href="/about/org/od/ohe"> <span>Office of Health Equity (OHE)</span> </a> </li> <li class="mobile-menu-link"> <a href="/about/org/od/olppe"> <span>Office of Legislation, Public Policy, and Ethics (OLPPE)</span> </a> </li> <li class="mobile-menu-link"> <a href="/about/org/od/ospra"> <span>Office of Science Policy, Reporting, and Program Analysis (OSPRA)</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-DivisionofExtramuralResearch(DER)" type="button" > <span>Division of Extramural Research (DER)</span> </button> <ul id="basic-mobile-nav-section-DivisionofExtramuralResearch(DER)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/about/org/der" class="parent-link"> <span>Division of Extramural Research (DER)</span> </a> </li> <li class="mobile-menu-link"> <a href="/about/org/der/branches"> <span>Extramural Scientific Branches</span> </a> </li> </ul> </li> <li class="mobile-menu-link"> <button class="usa-accordion__button" aria-expanded="false" aria-controls="basic-mobile-nav-section-DivisionofExtramuralActivities(DEA)" type="button" > <span>Division of Extramural Activities (DEA)</span> </button> <ul id="basic-mobile-nav-section-DivisionofExtramuralActivities(DEA)" class="usa-accordion__content" data-allow-multiple> <li class="mobile-menu-link"> <a href="/about/org/dea" class="parent-link"> <span>Division of Extramural Activities (DEA)</span> </a> </li> <li class="mobile-menu-link"> <a href="/about/org/dea/gmb"> <span>Grants Management Branch (GMB)</span> </a> </li> <li class="mobile-menu-link"> <a href="/about/org/dea/oep"> <span>Office of Extramural 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googleon: index --> <div class="region region-content"> <div data-drupal-messages-fallback class="hidden"></div> <div id="block-nichd-page-title" class="block block-core block-page-title-block"> <h1 class="uswds-page-title page-title"><span class="field field--name-title field--type-string field--label-hidden">NICHD Fragile X Syndrome Research Information</span> </h1> </div> <div id="block-mobile-related-external-spn-url" class="block block-ctools-block block-entity-field:node:field-related-external-spn-url related-external-link display-block tablet:display-none mobile-related-external-link"> <div class="button-wrapper usa-button"> <a lang="es" class="button-link" aria-label="Visita esta página en español" href="https://espanol.nichd.nih.gov/salud/temas/fragilex/investigaciones">En Español</a> <svg class="usa-icon" aria-hidden="true" focusable="false" role="img"> <use xlink:href="/themes/custom/uswds_nichd/assets/img/sprite.svg#arrow_forward"></use> </svg> </div> </div> <div id="block-nichd-content" class="block block-system block-system-main-block"> <article data-history-node-id="1752"> <div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>NICHD conducts and supports research on many aspects of Fragile X syndrome, including its symptoms and how it might be prevented or treated. NICHD-supported researchers discovered the genetic cause for Fragile X syndrome in 1991, and ongoing studies are investigating the far-reaching effects of the gene on development.</p> <p>Some studies focus on families with known <em>FMR1</em> mutations and premutations to identify associations with other diseases or conditions. Researchers are also seeking easier, less expensive, and more accurate screening and diagnostic tests that can provide detailed information on a person’s <em>FMR1</em> status. NICHD researchers are also studying associated disorders, including <a href="/health/topics/fxpoi">FXPOI</a> and <a href="/health/topics/fxtas">FXTAS</a>.</p> <div data-embed-button="nichd_accordion_embed_btn" data-entity-embed-display="view_mode:nichd_accordion.accordion" data-entity-type="nichd_accordion" data-entity-uuid="3edef91c-37d6-462d-b41d-c627ac8f85f1" data-langcode="en" data-entity-embed-display-settings="[]" class="embedded-entity"> <div class="usa-accordion usa-accordion--multiselectable" data-allow-multiple> <h2 class="usa-accordion__heading"> <button id="goals" class="usa-accordion__button" aria-expanded="false" aria-controls="accordion-id-1953"> <span class="accordion-button-icon"></span> NICHD Research Goals </button> </h2> <div id="accordion-id-1953" class="usa-accordion__content usa-prose"> <div class="clearfix text-formatted field field--name-field-nichd-accordion-body field--type-text-long field--label-hidden field__item"><p>Problems associated with mutation of <em>FMR1</em> fall into the research portfolios of multiple NIH Institutes, including NICHD. To help coordinate research on <em>FMR1</em>, NICHD leads the NIH Fragile X Research Coordinating Group, which includes nine NIH Institutes with research interests in different aspects of Fragile X. The Group consulted with outside experts and in 2008 published a long-term agenda for <em>FMR1</em> research, the <a href="/publications/product/318?from=&pubs_id=5729">NIH Research Plan on Fragile X Syndrome and Associated Disorders</a>. Finding treatments and supporting families affected by Fragile X and its related disorders are two of the major goals of the Plan.</p> <p>The NIH is committed to continuing to learn as much as possible about the <em>FMR1</em> gene and its far-reaching effects. The story of Fragile X might also serve as an effective and useful model for studying other diseases and for moving research discoveries from the laboratory into everyday usage.</p> <p>Among the Committee’s goals related to Fragile X syndrome are the following:</p> <ul type="disc"> <li>Goal I. Advance understanding of the pathophysiology of Fragile X syndrome.</li> <li>Goal II. Improve appropriate and timely diagnosis of individuals with Fragile X by conducting population-based screens for the syndrome.</li> <li>Goal III. Validate and use functional measures of the manifestation of Fragile X across the life span.</li> <li>Goal IV. Initiate a broad-based program of research on the efficacy of treatments for Fragile X syndrome.</li> <li>Goal V. Advance understanding of the ramifications of Fragile X syndrome for families.</li> <li>Goal VI. Create an infrastructure and resources for research in Fragile X to maximize research efficiencies and promote large-scale research collaborations.</li> </ul> <p>NICHD’s goals for research on Fragile X syndrome are consistent with those outlined in the <a href="/publications/product/318?from=&pubs_id=5729">NIH Research Plan on Fragile X Syndrome and Associated Disorders</a>. NICHD research efforts related to Fragile X, FXPOI, and FXTAS address each condition specifically as well as more general aspects of Fragile X mutations that may affect all three conditions. Some specific NICHD research goals include the following:</p> <ul type="disc"> <li>Understanding how individuals with Fragile X syndrome learn language, process visual information, and react to sensory information. In concert with these studies, other research is detailing brain development in infants with Fragile X to understand how their brains differ from typically developing children and from children with autism and other developmental disorders.</li> <li>Finding treatments for the underlying protein dysfunction that causes many of the intellectual and developmental symptoms of Fragile X syndrome, and learning how this dysfunction is involved with Fragile X-associated disorders.</li> <li>Understanding which diseases or health problems are associated with the mutated Fragile X gene and determining whether the mutated gene affects risk for other diseases or conditions.</li> </ul> </div> </div> <h2 class="usa-accordion__heading"> <button id="activities" class="usa-accordion__button" aria-expanded="false" aria-controls="accordion-id-1954"> <span class="accordion-button-icon"></span> Research Activities and Advances </button> </h2> <div id="accordion-id-1954" class="usa-accordion__content usa-prose"> <div class="clearfix text-formatted field field--name-field-nichd-accordion-body field--type-text-long field--label-hidden field__item"><p>Through its intramural and extramural organizational units, NICHD supports and conducts a broad range of research on Fragile X syndrome. Short descriptions of selected research studies are included below. NICHD researchers are also studying Fragile X-associated disorders, including <a href="/health/topics/fxpoi">Fragile X-associated primary ovarian insufficiency</a> and <a href="/health/topics/fxtas">Fragile X-associated tremor/ataxia syndrome</a>.</p> <ul type="disc"> <li><a href="#institute">Institute Activities and Advances</a></li> <li><a href="#other">Other Activities and Advances</a></li> </ul> <h3><a name="institute"></a>Institute Activities and Advances</h3> <p>Much of NICHD's research on Fragile X syndrome is supported through its <a href="/about/org/der/branches/iddb">Intellectual and Developmental Disabilities Branch (IDDB)</a>. In addition to individual projects, the IDDB supports research on Fragile X through the <a href="/research/supported/ccrfx">Fragile X Syndrome Research Centers</a>. The <a href="#other">Other Activities and Advances</a> section has information about these centers.</p> <h4>Finding Treatments for Fragile X Syndrome</h4> <p>IDDB-supported researchers are currently studying the "mGluR Theory" of Fragile X syndrome: that exaggerated signaling in mGluR (metabotropic glutamate receptor) pathways from missing FMRP leads to the condition's various symptoms.</p> <p>Using a Fragile X mouse model, researchers generated mice with 50% lower expression of mGluR5. Several aspects of Fragile X were improved, as the risk of seizures was reduced and there was better eye development, brain development, and behavior.<sup><a href="#f1">1</a></sup> Current research will test whether inhibiting mGluR5 after birth can prevent Fragile X syndrome in this mouse model. The researchers will also inhibit mGluR5 after Fragile X symptoms are present to investigate whether such an action can reverse the symptoms.</p> <p>Another recent study investigated a possible shared mechanism for Fragile X syndrome and tuberous sclerosis complex (TSC), another genetic disorder characterized by intellectual disability and autism. Scientists measured brain protein synthesis in mouse models for TSC and Fragile X syndrome and revealed that the <em>Fmr1</em> mutation in Fragile X causes increased synaptic protein synthesis that can be corrected by inhibiting mGluR5. Interestingly, the <em>Tsc2</em> mutation in TSC was found to decrease synaptic protein synthesis, and this could be corrected by augmenting mGluR5. The researchers also found that the deficits in the mouse models were ameliorated when the mice were bred to carry both mutations. The findings suggest that deviations in the synthesis of these proteins—in either direction—can lead to behavioral impairments that are shared across genetic disorders. In addition, the findings suggest that therapies designed to correct one cause of ASD are not likely to be effective for all other causes.</p> <p>In May 2010, a clinical trial of an mGluR5 antagonist began in adults with Fragile X syndrome. If the results from the adult study show promise, the drug can be tested in clinical trials with children. NICHD, through its <a href="/research/supported/bpca">Best Pharmaceuticals for Children Act</a> activities, will add its support to that of the National Institute of Mental Health and other Institutes and organizations for the pediatric clinical trials.</p> <h4>Better Diagnostics and Screening Tools for Fragile X and Premutations</h4> <p>Several NICHD-supported research groups are seeking ways to better diagnose and screen newborns for Fragile X mutations and premutations. Early physical recognition of the characteristics of Fragile X syndrome is difficult, and new technology is being designed to detect all categories of Fragile X alleles, including full mutation expansions.<sup><a href="#f2">2</a></sup></p> <h4>Brain Development in Fragile X Syndrome</h4> <p>By the time infants with Fragile X syndrome reach 2 years old, they have a distinct pattern of brain abnormalities. Two-year-olds who have both Fragile X and an <a href="/health/topics/autism">autism spectrum disorder (ASD)</a> also have their own unique pattern.<sup><a href="#f3">3</a>,<a href="#f4">4</a></sup></p> <p>A long-term study is set to discover how these patterns develop and how they are related to the signs and symptoms of Fragile X. Supported by NICHD's IDDB, the study's researchers are examining early brain development and behavior in infants with Fragile X syndrome. The study will ultimately include 334 infants, some with Fragile X, some with ASD, and some at risk for ASD, as well as a set of control infants. The researchers will perform magnetic resonance imaging (MRI) scans at 6, 12, and 24 months of age and will collect behavioral information as well. This study has the potential to distinguish specific behavioral, genetic, and neurobiological features that characterize infants with Fragile X syndrome as compared to infants at risk for autism without Fragile X syndrome and to those with typical development.<sup><a href="#f5">5</a></sup></p> <h4>The Role of Maternal Autoimmune Disease in Fragile X Syndrome</h4> <p>About 60% of children with Fragile X also have an ASD, but only about 4% of children with ASDs have the <em>FMR1</em> gene mutation. It is unclear at this point why ASDs affect only a rather small portion of children with Fragile X. One current line of research is to examine the role played by having a mother with an autoimmune disease, such as thyroid disease, lupus, multiple sclerosis, or fibromyalgia.</p> <p>A recent study<sup><a href="#f6">6</a></sup> revealed that children with Fragile X whose mothers had a history of autoimmune disease displayed more problems with tics and a higher rate of seizures than did those whose mothers did not have this history. The children in the first group also had higher scores on measures of behavioral concerns, including aggression, depression, and withdrawal. The groups did not differ on rates of ASD, intellectual disability, head size, or sleep problems. These results suggest that future research should consider how autoimmune disease in mothers may interact with the <em>FMR1</em> mutation to disrupt brain development in their offspring and make children with Fragile X syndrome more susceptible to seizures, tics, and behavior problems.</p> <h4>Protein Missing in Fragile X Uses microRNAs to Act as a "Toggle Switch" in the Brain</h4> <p>Recent research supported by NICHD has demonstrated how the protein missing in Fragile X syndrome acts as a molecular "toggle switch" in brain cells.<sup><a href="#f7">7</a></sup> In Fragile X syndrome, a genetic mutation removes the FMRP from cells, interfering with protein production and signaling at the synapses (the junctions between brain cells where chemical communication occurs). This leads to structural changes and an impairment of the cells' ability to respond to chemical signals, interfering with learning and memory. NICHD-supported scientists determined how the FMRP uses short RNA molecules (microRNAs) to switch on and off the production of other proteins in response to chemical signals. This finding demonstrates the importance of microRNAs in neurological development and diseases such as Fragile X.</p> <h4>New Drug Target Identified for Fragile X Syndrome</h4> <p>NIH-supported researchers have found that a class of drugs called PI3 kinase inhibitors can correct defects in the anatomy of neurons in a mouse model of Fragile X syndrome.<sup><a href="#f8">8</a></sup> In Fragile X syndrome, a gene mutation leads to the absence of FMRP, and without FMRP to regulate protein production and signaling, neurons produce excess amounts of certain proteins at synapses. This leads to structural changes and an impairment of the cells' ability to respond to chemical signals, interfering with learning and memory. In the mouse model of Fragile X, using a drug to inhibit the action of the PI3 kinase enzyme dampened the synaptic proteins and could potentially reverse the resulting structural changes. The drug was able to restore normal levels of protein production at synapses, suggesting that PI3 kinase inhibitors could help improve learning and cognition in individuals with Fragile X syndrome.</p> <h3><a name="other"></a>Other Activities and Advances</h3> <p>To achieve its research goals for Fragile X syndrome and associated disorders, NICHD is involved with a variety of activities. Some of these activities are managed through the components listed above; others are part of NIH-wide or collaborative efforts in which NICHD participates.</p> <ul type="disc"> <li>NICHD's IDDB funds three <a href="/research/supported/ccrfx">Fragile X Syndrome Research Centers</a>. These centers are geared toward stimulating multidisciplinary, multi-institutional research and translating basic research findings into clinical practice.</li> <li>The <strong>NIH Fragile X Research Coordinating Group</strong>, led by NICHD, includes nine Institutes with research interests in different aspects of Fragile X or its associated disorders. Several years ago the Group consulted with outside experts and then in 2008 published a long-term agenda for <em>FMR1</em> research, called the <a href="/publications/product/318?from=&pubs_id=5729">NIH Research Plan on Fragile X Syndrome and Associated Disorders</a>. Finding treatments and supporting families affected by Fragile X and its related disorders are major goals of the Plan.</li> <li>The Group recently issued a Request for Information to get feedback on the NIH Research Plan and to seek creative, concrete suggestions from scientific experts in the research and clinical communities, representatives for affected individuals and family members, and pertinent federal agencies. For details, visit <a href="http://grants.nih.gov/grants/guide/notice-files/NOT-HD-12-012.html" target="_blank">http://grants.nih.gov/grants/guide/notice-files/NOT-HD-12-012.html</a>.</li> </ul> </div> </div> </div> </div> <div data-embed-button="nichd_citations_embed_btn" data-entity-embed-display="view_mode:nichd_citations.citations" data-entity-type="nichd_citations" data-entity-uuid="3699202b-8bcd-40da-82af-b968e56cfe09" data-langcode="en" data-entity-embed-display-settings="[]" class="embedded-entity"> <div class="nichd_citations usa-accordion margin-top-2"> <h2> Citations </h2> <button class="usa-accordion__button citationsanchor" aria-expanded="true" aria-controls="citation-id-171" aria-label="Toggle citations open and closed"> </button> <div id="citation-id-171" class="usa-accordion__content usa-prose citations"> <div class="clearfix text-formatted field field--name-field-body field--type-text-long field--label-hidden field__item"><ol> <li><a name="f1"></a>Dölen, G., Osterweil, E., Rao, B. S., Smith, G. B., Auerbach, R. D., Chattarji, S., et al. (2007). Correction of fragile X syndrome in mice. <em>Neuron, 56</em>, 955-962.</li> <li><a name="f2"></a>Latham, G. J. <em>Enabling use of blood spot cards for accurate high-throughput fragile X screening</em>. Retrieved May 7, 2012, from <a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=8124769&icde=11603103" target="_blank">https://reporter.nih.gov/project-details/8124769</a></li> <li><a name="f3"></a>Hoeft, F., Walter, E., Lightbody, A. A., Hazlett, H. C., Chang, C., Piven, J., et al. (2011). Neuroanatomical differences in toddler boys with fragile X syndrome and idiopathic autism. <em>Archives of General Psychiatry, 68</em>, 295-305.</li> <li><a name="f4"></a>Hazlett, H. C., Poe, M. D., Lightbody, A. A., Gerig, G., Macfall, J. R., Ross, A. K., et al. (2009). Teasing apart the heterogeneity of autism: Same behavior, different brains in toddlers with fragile X syndrome and autism. <em>Journal of Neurodevelopmental Disorders, 1</em>, 81-90.</li> <li><a name="f5"></a>Hazlett, H. C. <em>A longitudinal MRI study of brain development in Fragile X syndrome</em>. Retrieved May 7, 2012, from <a href="https://projectreporter.nih.gov/project_info_description.cfm?aid=7944032&icde=11603700" target="_blank">https://reporter.nih.gov/project-details/7944032</a></li> <li><a name="f6"></a>Chonchaiya, W., Tassone, F., Ashwood, P., Hessl, D., Schneider, A., Campos, L., et al. (2010). Autoimmune disease in mothers with the <em>FMR1</em> premutation is associated with seizures in their children with fragile X syndrome. <em>Human Genetics, 128</em>, 539-548.</li> <li><a name="f7"></a>Muddashetty, R. S., Nalavadi, V. C., Gross, C., Yao, X., Xing, L., Laur, O., et al. (2011). Reversible inhibition of PSD-95 mRNA translation by miR-125a, FMRP phosphorylation, and mGluR signaling. <em>Molecular Cell, 42</em>, 673-688.</li> <li><a name="f8"></a>Gross, C., Nakamoto, M., Yao, X., Chan, C. B., Yim, S. Y., Ye, K., et al. (2010). Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic agent in fragile X syndrome. <em>Journal of Neuroscience, 30</em>, 10624-10638.</li> </ol> </div> </div> </div> </div> <p> </p> </div> </div> </article> </div> </div> <!-- googleoff: index --> <div class="usa-footer__return-to-top"> <a href="#" class="back-to-top-text"> <img class="bttarrow-icon" src="/themes/custom/uswds_nichd/img/backtotop.svg" alt="top of page"> BACK TO TOP </a> </div> </div> <aside aria-label="sidebar-second" class="tablet:grid-col-4 sidebar-second padding-top-2"> <div class="region region-sidebar-second"> <div id="block-related-external-spn-url" class="block block-ctools-block block-entity-field:node:field-related-external-spn-url display-none tablet:display-block related-external-link"> <div class="button-wrapper usa-button"> <a lang="es" class="button-link" aria-label="Visita esta página en español" href="https://espanol.nichd.nih.gov/salud/temas/fragilex/investigaciones">En 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