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class="data">172</p></div></a><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="user-bio-container"><div class="profile-bio fake-truncate js-profile-about" style="margin: 0px;">Prof Girija Wagh MD FICOG Dip in Gyn Endoscopy, FICS<br /><div class="js-profile-less-about u-linkUnstyled u-tcGrayDarker u-textDecorationUnderline u-displayNone">less</div></div></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="69187415" href="https://www.academia.edu/Documents/in/Preeklampsia_Berat"><div id="js-react-on-rails-context" style="display:none" 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class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Girija Wagh</h3></div><div class="js-work-strip profile--work_container" data-work-id="125507443"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/125507443/Evaluation_of_Aetiopathogenesis_of_Spontaneous_Preterm_Parturition_Syndrome_A_Cross_Sectional_Study"><img alt="Research paper thumbnail of Evaluation of Aetiopathogenesis of Spontaneous Preterm Parturition Syndrome: A Cross Sectional Study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/125507443/Evaluation_of_Aetiopathogenesis_of_Spontaneous_Preterm_Parturition_Syndrome_A_Cross_Sectional_Study">Evaluation of Aetiopathogenesis of Spontaneous Preterm Parturition Syndrome: A Cross Sectional Study</a></div><div class="wp-workCard_item"><span>Indian journal of obstetrics and gynecology</span><span>, Jun 14, 2022</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="125507443"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item 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href="https://www.academia.edu/125507440/An_expert_consensus_on_the_medical_management_of_uterine_fibroids_and_complementing_surgical_management_with_focus_on_low_dose_mifepristone"><img alt="Research paper thumbnail of An expert consensus on the medical management of uterine fibroids and complementing surgical management with focus on low dose mifepristone" class="work-thumbnail" src="https://attachments.academia-assets.com/119537804/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/125507440/An_expert_consensus_on_the_medical_management_of_uterine_fibroids_and_complementing_surgical_management_with_focus_on_low_dose_mifepristone">An expert consensus on the medical management of uterine fibroids and complementing surgical management with focus on low dose mifepristone</a></div><div class="wp-workCard_item"><span>International journal of clinical obstetrics and gynaecology</span><span>, May 1, 2024</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6db4ca5bab5d257d2f619ec56dbb31d3" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":119537804,"asset_id":125507440,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/119537804/download_file?st=MTczMzAxNzkyNCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="125507440"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa 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transporters in syncytiotrophoblast membranes in preeclampsia placentae" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/117807292/Altered_expression_of_nutrient_transporters_in_syncytiotrophoblast_membranes_in_preeclampsia_placentae">Altered expression of nutrient transporters in syncytiotrophoblast membranes in preeclampsia placentae</a></div><div class="wp-workCard_item"><span>Placenta</span><span>, Aug 1, 2023</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper 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class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/117807291/Effect_of_combination_of_Curcuma_longa_with_Emblica_officinalis_in_females_with_polycystic_ovarian_syndrome_An_open_label_randomized_active_controlled_exploratory_clinical_study">Effect of combination of Curcuma longa with Emblica officinalis in females with polycystic ovarian syndrome: An open-label, randomized active-controlled, exploratory clinical study</a></div><div class="wp-workCard_item"><span>Journal of Diabetology : Official Journal of Diabetes in Asia Study Group</span><span>, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Introduction: Polycystic ovarian syndrome (PCOS) is the commonest cause of infertility due to ano...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Introduction: Polycystic ovarian syndrome (PCOS) is the commonest cause of infertility due to anovulation. The combination of Curcuma longa (CL) and Emblica officinalis (EO) is known to ameliorate diabetes and, thereby, may resurrect PCOS. The present study aimed to evaluate the effect of this combination prepared by two different methods, independently and with metformin (Met), compared with Met in PCOS on glycaemic control, inflammation, adipokines, and anthropometry. Aim: The aim of the study was to evaluate the effect of the combination of CL and EO, prepared by two different methods, independently and with Met, compared with Met in PCOS. Materials and Methods: PCOS women aged 18–35 years were selected through Rotterdam criteria from a tertiary care teaching hospital setting post-Ethics Committee permission. They were randomized to five groups (eight per group); combination of CL and EO prepared by traditional method (TF- Traditional Formulation), standardized extraction method (PNAE- Pharmanza Nisha Amalaki Extract), standard control Metformin (Met) and their combinations, TF + Met and PNAE + Met for 90 days. Fasting glucose, insulin, lipid profile, reproductive hormones (luteinizing hormone [LH], follicle-stimulating hormone [FSH], and free testosterone), inflammatory markers (tumor necrosis factor-alpha [TNF-α], interleukin [IL]-6), and adipokines (leptin and adiponectin) were done at baseline and day 90, whereas anthropometry was done monthly. Results: Of 48 randomized women, 37 completed the study. TF and Met groups demonstrated higher weight decrease, whereas TF + Met significantly decreased waist circumference. Blood glucose, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) decreased in all groups except glucose in TF + Met and HOMA-IR in the Met group. Only PNAE decreased free testosterone. TNF-α increased while leptin decreased in all groups. Both TF and PNAE, with Met reduced IL 6, significantly only in PNAE + Met group. Similarly, both TF and PNAE, with Met reduced LH/FSH ratio and significantly increased adiponectin. Two females, each, conceived in TF and PNAE, whereas one was in PNAE + Met group. No adverse events were reported. Conclusion: Both botanical formulations, TF and PNAE, were comparable to Met. The standardized extracts formulation PNAE seems more promising due to administration ease, smaller dose, and consistent bioactives.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117807291"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117807291"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117807291; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=117807291]").text(description); $(".js-view-count[data-work-id=117807291]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 117807291; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='117807291']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 117807291, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=117807291]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":117807291,"title":"Effect of combination of Curcuma longa with Emblica officinalis in females with polycystic ovarian syndrome: An open-label, randomized active-controlled, exploratory clinical study","translated_title":"","metadata":{"abstract":"Introduction: Polycystic ovarian syndrome (PCOS) is the commonest cause of infertility due to anovulation. The combination of Curcuma longa (CL) and Emblica officinalis (EO) is known to ameliorate diabetes and, thereby, may resurrect PCOS. The present study aimed to evaluate the effect of this combination prepared by two different methods, independently and with metformin (Met), compared with Met in PCOS on glycaemic control, inflammation, adipokines, and anthropometry. Aim: The aim of the study was to evaluate the effect of the combination of CL and EO, prepared by two different methods, independently and with Met, compared with Met in PCOS. Materials and Methods: PCOS women aged 18–35 years were selected through Rotterdam criteria from a tertiary care teaching hospital setting post-Ethics Committee permission. They were randomized to five groups (eight per group); combination of CL and EO prepared by traditional method (TF- Traditional Formulation), standardized extraction method (PNAE- Pharmanza Nisha Amalaki Extract), standard control Metformin (Met) and their combinations, TF + Met and PNAE + Met for 90 days. Fasting glucose, insulin, lipid profile, reproductive hormones (luteinizing hormone [LH], follicle-stimulating hormone [FSH], and free testosterone), inflammatory markers (tumor necrosis factor-alpha [TNF-α], interleukin [IL]-6), and adipokines (leptin and adiponectin) were done at baseline and day 90, whereas anthropometry was done monthly. Results: Of 48 randomized women, 37 completed the study. TF and Met groups demonstrated higher weight decrease, whereas TF + Met significantly decreased waist circumference. Blood glucose, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) decreased in all groups except glucose in TF + Met and HOMA-IR in the Met group. Only PNAE decreased free testosterone. TNF-α increased while leptin decreased in all groups. Both TF and PNAE, with Met reduced IL 6, significantly only in PNAE + Met group. Similarly, both TF and PNAE, with Met reduced LH/FSH ratio and significantly increased adiponectin. Two females, each, conceived in TF and PNAE, whereas one was in PNAE + Met group. No adverse events were reported. Conclusion: Both botanical formulations, TF and PNAE, were comparable to Met. The standardized extracts formulation PNAE seems more promising due to administration ease, smaller dose, and consistent bioactives.","publisher":"Medknow","publication_date":{"day":null,"month":null,"year":2023,"errors":{}},"publication_name":"Journal of Diabetology : Official Journal of Diabetes in Asia Study Group"},"translated_abstract":"Introduction: Polycystic ovarian syndrome (PCOS) is the commonest cause of infertility due to anovulation. The combination of Curcuma longa (CL) and Emblica officinalis (EO) is known to ameliorate diabetes and, thereby, may resurrect PCOS. The present study aimed to evaluate the effect of this combination prepared by two different methods, independently and with metformin (Met), compared with Met in PCOS on glycaemic control, inflammation, adipokines, and anthropometry. Aim: The aim of the study was to evaluate the effect of the combination of CL and EO, prepared by two different methods, independently and with Met, compared with Met in PCOS. Materials and Methods: PCOS women aged 18–35 years were selected through Rotterdam criteria from a tertiary care teaching hospital setting post-Ethics Committee permission. They were randomized to five groups (eight per group); combination of CL and EO prepared by traditional method (TF- Traditional Formulation), standardized extraction method (PNAE- Pharmanza Nisha Amalaki Extract), standard control Metformin (Met) and their combinations, TF + Met and PNAE + Met for 90 days. Fasting glucose, insulin, lipid profile, reproductive hormones (luteinizing hormone [LH], follicle-stimulating hormone [FSH], and free testosterone), inflammatory markers (tumor necrosis factor-alpha [TNF-α], interleukin [IL]-6), and adipokines (leptin and adiponectin) were done at baseline and day 90, whereas anthropometry was done monthly. Results: Of 48 randomized women, 37 completed the study. TF and Met groups demonstrated higher weight decrease, whereas TF + Met significantly decreased waist circumference. Blood glucose, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) decreased in all groups except glucose in TF + Met and HOMA-IR in the Met group. Only PNAE decreased free testosterone. TNF-α increased while leptin decreased in all groups. Both TF and PNAE, with Met reduced IL 6, significantly only in PNAE + Met group. Similarly, both TF and PNAE, with Met reduced LH/FSH ratio and significantly increased adiponectin. Two females, each, conceived in TF and PNAE, whereas one was in PNAE + Met group. No adverse events were reported. Conclusion: Both botanical formulations, TF and PNAE, were comparable to Met. The standardized extracts formulation PNAE seems more promising due to administration ease, smaller dose, and consistent bioactives.","internal_url":"https://www.academia.edu/117807291/Effect_of_combination_of_Curcuma_longa_with_Emblica_officinalis_in_females_with_polycystic_ovarian_syndrome_An_open_label_randomized_active_controlled_exploratory_clinical_study","translated_internal_url":"","created_at":"2024-04-20T22:14:15.091-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":69187415,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Effect_of_combination_of_Curcuma_longa_with_Emblica_officinalis_in_females_with_polycystic_ovarian_syndrome_An_open_label_randomized_active_controlled_exploratory_clinical_study","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":69187415,"first_name":"Girija","middle_initials":null,"last_name":"Wagh","page_name":"GirijaWagh","domain_name":"independent","created_at":"2017-10-08T07:35:52.661-07:00","display_name":"Girija Wagh","url":"https://independent.academia.edu/GirijaWagh"},"attachments":[],"research_interests":[{"id":614,"name":"Diabetology","url":"https://www.academia.edu/Documents/in/Diabetology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":51373,"name":"Insulin Resistance","url":"https://www.academia.edu/Documents/in/Insulin_Resistance"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"}],"urls":[{"id":41261872,"url":"https://doi.org/10.4103/jod.jod_17_23"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="117807290"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/117807290/Comparison_and_correlation_of_visual_inspection_with_acetic_acid_papanicolaou_smear_and_colposcopy_in_detection_of_precancerous_cervical_lesions"><img alt="Research paper thumbnail of Comparison and correlation of visual inspection with acetic acid, papanicolaou smear and colposcopy in detection of precancerous cervical lesions" class="work-thumbnail" src="https://attachments.academia-assets.com/113575504/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/117807290/Comparison_and_correlation_of_visual_inspection_with_acetic_acid_papanicolaou_smear_and_colposcopy_in_detection_of_precancerous_cervical_lesions">Comparison and correlation of visual inspection with acetic acid, papanicolaou smear and colposcopy in detection of precancerous cervical lesions</a></div><div class="wp-workCard_item"><span>International journal of reproduction, contraception, obstetrics and gynecology</span><span>, 2016</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="78741f077fa6ab31b211fc45a2064f03" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":113575504,"asset_id":117807290,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/113575504/download_file?st=MTczMzAxNzkyNCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117807290"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117807290"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117807290; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=117807290]").text(description); $(".js-view-count[data-work-id=117807290]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 117807290; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='117807290']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 117807290, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "78741f077fa6ab31b211fc45a2064f03" } } $('.js-work-strip[data-work-id=117807290]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":117807290,"title":"Comparison and correlation of visual inspection with acetic acid, papanicolaou smear and colposcopy in detection of precancerous cervical lesions","translated_title":"","metadata":{"publisher":"Medip Academy","grobid_abstract":"Cervical cancer has huge burden on national health system. 1,2 Cervical cancer kills approximately 230,000 women annually, with the vast majority of deaths occurring in developing countries. Worldwide, cervical carcinoma is the fifth most common cancer-related cause of death among women in the developing world; it is the leading cause of cancer death in women. 1 Global distribution of cervical cancer varies, with Africa, Asia, and Latin America bearing a substantial burden of this disease. 1,2 Cervical cancer prevention programs in both developed and developing nations generally have relied on cytological testing using the papanicolaou (Pap) smear test. Such screening programs can be expensive, prone to error, and logistically difficult to implement particularly in developing countries.","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"International journal of reproduction, contraception, obstetrics and gynecology","grobid_abstract_attachment_id":113575504},"translated_abstract":null,"internal_url":"https://www.academia.edu/117807290/Comparison_and_correlation_of_visual_inspection_with_acetic_acid_papanicolaou_smear_and_colposcopy_in_detection_of_precancerous_cervical_lesions","translated_internal_url":"","created_at":"2024-04-20T22:14:14.819-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":69187415,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":113575504,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/113575504/thumbnails/1.jpg","file_name":"399.pdf","download_url":"https://www.academia.edu/attachments/113575504/download_file?st=MTczMzAxNzkyNCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Comparison_and_correlation_of_visual_ins.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/113575504/399-libre.pdf?1713680398=\u0026response-content-disposition=attachment%3B+filename%3DComparison_and_correlation_of_visual_ins.pdf\u0026Expires=1733021524\u0026Signature=bwZJ7vaH-hmXDoSM92ibe3jW4iwByV-wzohj3MwTRnUCcQTr9K2aHOf6oVGX4nZ2Wlc507MgiwOee2gLciUzlWlvU8~t6FhhWNQjaitDp-aCVCuNqGSHwj7nNBixFJtoyz2enZon6qgkBNx53B4Ve1588gWjHcJCA6fUmEezrgxU3UM86Bn5Z-0ljjkLIVaL3QtnSjHeECd91M6bqawmbQ~lAG-nELC17YWlsSaXXARxGCgZkoVL5OT5FDJ6qJTNH4WTYnd2hoDlXYUDfaN0AaspSdmlRdCnAzgd-b7gq8OF1DlJIQm9Eh4~b9u9YdZ5xrbzwpOXatgixG2YEZMR~Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Comparison_and_correlation_of_visual_inspection_with_acetic_acid_papanicolaou_smear_and_colposcopy_in_detection_of_precancerous_cervical_lesions","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":69187415,"first_name":"Girija","middle_initials":null,"last_name":"Wagh","page_name":"GirijaWagh","domain_name":"independent","created_at":"2017-10-08T07:35:52.661-07:00","display_name":"Girija Wagh","url":"https://independent.academia.edu/GirijaWagh"},"attachments":[{"id":113575504,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/113575504/thumbnails/1.jpg","file_name":"399.pdf","download_url":"https://www.academia.edu/attachments/113575504/download_file?st=MTczMzAxNzkyNCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Comparison_and_correlation_of_visual_ins.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/113575504/399-libre.pdf?1713680398=\u0026response-content-disposition=attachment%3B+filename%3DComparison_and_correlation_of_visual_ins.pdf\u0026Expires=1733021524\u0026Signature=bwZJ7vaH-hmXDoSM92ibe3jW4iwByV-wzohj3MwTRnUCcQTr9K2aHOf6oVGX4nZ2Wlc507MgiwOee2gLciUzlWlvU8~t6FhhWNQjaitDp-aCVCuNqGSHwj7nNBixFJtoyz2enZon6qgkBNx53B4Ve1588gWjHcJCA6fUmEezrgxU3UM86Bn5Z-0ljjkLIVaL3QtnSjHeECd91M6bqawmbQ~lAG-nELC17YWlsSaXXARxGCgZkoVL5OT5FDJ6qJTNH4WTYnd2hoDlXYUDfaN0AaspSdmlRdCnAzgd-b7gq8OF1DlJIQm9Eh4~b9u9YdZ5xrbzwpOXatgixG2YEZMR~Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":625,"name":"Obstetrics","url":"https://www.academia.edu/Documents/in/Obstetrics"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":195979,"name":"Colposcopy","url":"https://www.academia.edu/Documents/in/Colposcopy"},{"id":203512,"name":"Cervical Cancer","url":"https://www.academia.edu/Documents/in/Cervical_Cancer"},{"id":339107,"name":"Gynecology","url":"https://www.academia.edu/Documents/in/Gynecology"},{"id":1355484,"name":"Cervix","url":"https://www.academia.edu/Documents/in/Cervix"}],"urls":[{"id":41261871,"url":"https://www.ijrcog.org/index.php/ijrcog/article/download/417/399"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="117807289"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/117807289/Evaluate_the_Feasibility_of_Surgical_Transversus_Abdominis_Plane_Block_for_Postoperative_Analgesia_After_Cesarean_Section"><img alt="Research paper thumbnail of Evaluate the Feasibility of Surgical Transversus Abdominis Plane Block for Postoperative Analgesia After Cesarean Section" class="work-thumbnail" src="https://attachments.academia-assets.com/113575533/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/117807289/Evaluate_the_Feasibility_of_Surgical_Transversus_Abdominis_Plane_Block_for_Postoperative_Analgesia_After_Cesarean_Section">Evaluate the Feasibility of Surgical Transversus Abdominis Plane Block for Postoperative Analgesia After Cesarean Section</a></div><div class="wp-workCard_item"><span>The Journal of Obstetrics and Gynecology of India</span><span>, Jun 8, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BackgroundTransversus abdominis plane (TAP) block is a fascial plane block providing postoperativ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BackgroundTransversus abdominis plane (TAP) block is a fascial plane block providing postoperative analgesia after lower abdominal surgeries including Cesarean section. Conventionally, it is administered under ultrasound guidance or by blind technique. We studied a novel transperitoneal surgical TAP block for providing safe and effective analgesia after Cesarean section through transverse incision.MethodsA hundred patients who fulfilled the inclusion criteria were included in the study after obtaining informed written consent. They were randomized in two groups: Group A with surgical TAP block and Group B without TAP block as control. Surgical TAP block was administered by transperitoneal route before the closure of peritoneum with 0.25% bupivacaine (dose adjusted with weight of the patient), and visual analogue score was assessed by a blind assessor. Time for rescue analgesia was noted and analyzed with the ‘two independent sample t test.’ResultsThe duration of postoperative analgesia in hours was significantly longer in the TAP block group compared with the control group (5.14 ± 1.63 vs 2.61 ± 0.89, p < 0.001). There was no reported complication of the surgical technique or any adverse effect of the used drug.ConclusionSurgical TAP block via the transperitoneal route is a safe, easy and effective mode of providing postoperative analgesia after Cesarean section. This technique does not need any costly specialist equipment, overcomes the technical limitations of ultrasound-guided TAP block and can be used in obese patients also. It has almost no side effects, and the technique can be easily mastered.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8396a38608e6cfca9bbe97e3444fa2fd" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":113575533,"asset_id":117807289,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/113575533/download_file?st=MTczMzAxNzkyNCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117807289"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117807289"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117807289; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=117807289]").text(description); $(".js-view-count[data-work-id=117807289]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 117807289; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='117807289']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 117807289, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8396a38608e6cfca9bbe97e3444fa2fd" } } $('.js-work-strip[data-work-id=117807289]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":117807289,"title":"Evaluate the Feasibility of Surgical Transversus Abdominis Plane Block for Postoperative Analgesia After Cesarean Section","translated_title":"","metadata":{"abstract":"BackgroundTransversus abdominis plane (TAP) block is a fascial plane block providing postoperative analgesia after lower abdominal surgeries including Cesarean section. Conventionally, it is administered under ultrasound guidance or by blind technique. We studied a novel transperitoneal surgical TAP block for providing safe and effective analgesia after Cesarean section through transverse incision.MethodsA hundred patients who fulfilled the inclusion criteria were included in the study after obtaining informed written consent. They were randomized in two groups: Group A with surgical TAP block and Group B without TAP block as control. Surgical TAP block was administered by transperitoneal route before the closure of peritoneum with 0.25% bupivacaine (dose adjusted with weight of the patient), and visual analogue score was assessed by a blind assessor. Time for rescue analgesia was noted and analyzed with the ‘two independent sample t test.’ResultsThe duration of postoperative analgesia in hours was significantly longer in the TAP block group compared with the control group (5.14 ± 1.63 vs 2.61 ± 0.89, p \u003c 0.001). There was no reported complication of the surgical technique or any adverse effect of the used drug.ConclusionSurgical TAP block via the transperitoneal route is a safe, easy and effective mode of providing postoperative analgesia after Cesarean section. This technique does not need any costly specialist equipment, overcomes the technical limitations of ultrasound-guided TAP block and can be used in obese patients also. It has almost no side effects, and the technique can be easily mastered.","publisher":"Springer Science+Business Media","publication_date":{"day":8,"month":6,"year":2019,"errors":{}},"publication_name":"The Journal of Obstetrics and Gynecology of India"},"translated_abstract":"BackgroundTransversus abdominis plane (TAP) block is a fascial plane block providing postoperative analgesia after lower abdominal surgeries including Cesarean section. Conventionally, it is administered under ultrasound guidance or by blind technique. We studied a novel transperitoneal surgical TAP block for providing safe and effective analgesia after Cesarean section through transverse incision.MethodsA hundred patients who fulfilled the inclusion criteria were included in the study after obtaining informed written consent. They were randomized in two groups: Group A with surgical TAP block and Group B without TAP block as control. Surgical TAP block was administered by transperitoneal route before the closure of peritoneum with 0.25% bupivacaine (dose adjusted with weight of the patient), and visual analogue score was assessed by a blind assessor. Time for rescue analgesia was noted and analyzed with the ‘two independent sample t test.’ResultsThe duration of postoperative analgesia in hours was significantly longer in the TAP block group compared with the control group (5.14 ± 1.63 vs 2.61 ± 0.89, p \u003c 0.001). There was no reported complication of the surgical technique or any adverse effect of the used drug.ConclusionSurgical TAP block via the transperitoneal route is a safe, easy and effective mode of providing postoperative analgesia after Cesarean section. This technique does not need any costly specialist equipment, overcomes the technical limitations of ultrasound-guided TAP block and can be used in obese patients also. It has almost no side effects, and the technique can be easily mastered.","internal_url":"https://www.academia.edu/117807289/Evaluate_the_Feasibility_of_Surgical_Transversus_Abdominis_Plane_Block_for_Postoperative_Analgesia_After_Cesarean_Section","translated_internal_url":"","created_at":"2024-04-20T22:14:14.396-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":69187415,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":113575533,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/113575533/thumbnails/1.jpg","file_name":"s13224-019-01241-320240421-1-c0vzop.pdf","download_url":"https://www.academia.edu/attachments/113575533/download_file?st=MTczMzAxNzkyNCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Evaluate_the_Feasibility_of_Surgical_Tra.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/113575533/s13224-019-01241-320240421-1-c0vzop-libre.pdf?1713680388=\u0026response-content-disposition=attachment%3B+filename%3DEvaluate_the_Feasibility_of_Surgical_Tra.pdf\u0026Expires=1733021524\u0026Signature=edLS0GKuqtwGpbkHFOBjvhf4RttXeaRqGV5TVpPPKvxfG79LQugNbJ26-vBe~yYYTjA9qQiQzOq8Hq7WCnEPnB~A75Gsut0GSoqHTPVupiQsWMsKo-I34HKYc6MBo~kBvN2sGFXvHJhEX3v1taI3P3Lzz3gqlS1Os~Pzni~MbrC9UWRDbT5oBigQQyF2MpFr1~Gn2iuGLzjDGo30ez8D8iJPUhiu2TM254ph1H8ZyFS8WnYDCLAaJPijqpO-jJHOOy3~8ptl~OFjCVs8x13pQKTZ~AJMRuTg8k425FZ8TZCKJLElyulChUr2jeu9JyOfs~sKFjoVMXn3CKapokQHHQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Evaluate_the_Feasibility_of_Surgical_Transversus_Abdominis_Plane_Block_for_Postoperative_Analgesia_After_Cesarean_Section","translated_slug":"","page_count":4,"language":"en","content_type":"Work","owner":{"id":69187415,"first_name":"Girija","middle_initials":null,"last_name":"Wagh","page_name":"GirijaWagh","domain_name":"independent","created_at":"2017-10-08T07:35:52.661-07:00","display_name":"Girija Wagh","url":"https://independent.academia.edu/GirijaWagh"},"attachments":[{"id":113575533,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/113575533/thumbnails/1.jpg","file_name":"s13224-019-01241-320240421-1-c0vzop.pdf","download_url":"https://www.academia.edu/attachments/113575533/download_file?st=MTczMzAxNzkyNCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Evaluate_the_Feasibility_of_Surgical_Tra.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/113575533/s13224-019-01241-320240421-1-c0vzop-libre.pdf?1713680388=\u0026response-content-disposition=attachment%3B+filename%3DEvaluate_the_Feasibility_of_Surgical_Tra.pdf\u0026Expires=1733021524\u0026Signature=edLS0GKuqtwGpbkHFOBjvhf4RttXeaRqGV5TVpPPKvxfG79LQugNbJ26-vBe~yYYTjA9qQiQzOq8Hq7WCnEPnB~A75Gsut0GSoqHTPVupiQsWMsKo-I34HKYc6MBo~kBvN2sGFXvHJhEX3v1taI3P3Lzz3gqlS1Os~Pzni~MbrC9UWRDbT5oBigQQyF2MpFr1~Gn2iuGLzjDGo30ez8D8iJPUhiu2TM254ph1H8ZyFS8WnYDCLAaJPijqpO-jJHOOy3~8ptl~OFjCVs8x13pQKTZ~AJMRuTg8k425FZ8TZCKJLElyulChUr2jeu9JyOfs~sKFjoVMXn3CKapokQHHQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":129739,"name":"Anesthesia","url":"https://www.academia.edu/Documents/in/Anesthesia"},{"id":413196,"name":"Randomized Controlled Trial","url":"https://www.academia.edu/Documents/in/Randomized_Controlled_Trial"},{"id":2560488,"name":"Bupivacaine","url":"https://www.academia.edu/Documents/in/Bupivacaine"}],"urls":[{"id":41261870,"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661045"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="117807287"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/117807287/Association_between_proNGF_receptors_and_apoptotic_factors_in_human_placentae"><img alt="Research paper thumbnail of Association between proNGF receptors and apoptotic factors in human placentae" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/117807287/Association_between_proNGF_receptors_and_apoptotic_factors_in_human_placentae">Association between proNGF receptors and apoptotic factors in human placentae</a></div><div class="wp-workCard_item"><span>Placenta</span><span>, Aug 1, 2023</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117807287"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117807287"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117807287; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="117807286"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/117807286/Comparison_and_correlation_of_VIA_and_Pap_smear_in_detection_of_precancerous_cervical_lesions"><img alt="Research paper thumbnail of Comparison and correlation of VIA and Pap smear in detection of precancerous cervical lesions" class="work-thumbnail" src="https://attachments.academia-assets.com/113575503/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/117807286/Comparison_and_correlation_of_VIA_and_Pap_smear_in_detection_of_precancerous_cervical_lesions">Comparison and correlation of VIA and Pap smear in detection of precancerous cervical lesions</a></div><div class="wp-workCard_item"><span>International journal of applied research</span><span>, Jul 1, 2016</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d05ca02bb3fb95742cc3d233aeec37ee" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":113575503,"asset_id":117807286,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/113575503/download_file?st=MTczMzAxNzkyNCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117807286"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117807286"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117807286; 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To curb the disease, there is a need to develop a screening test that has good sensitivity and specificity. The present study is aimed to compare the effectiveness of the Pap smear, Visual Inspection with Acetic Acid (VIA) for mass screening of premalignant and malignant lesions of the cervix. Aims and objectives: 1. To screen women of 30-45 yrs. for precancerous or cancerous lesions of the cervix with VIA and Pap smear. 2. To compare and correlate the findings of Pap smear and VIA in detecting precancerous lesions of cervix. Material and Methods: This was a prospective observational study conducted from 01/01/2015 in the Department of Obstetrics and Gynaecology among 200 women of 30-45 yrs. of age group. Pap smear was performed by the conventional method and VIA was carried out for all. Results: The study group consisting of 200 women, 69% women were VIA negative and 31% were VIA positive. Out of 69% VIA negative patients pap results were supporting its interpretation as all pap tests were negative for precancerous and cancerous lesions of cervix. Out of VIA positive patients 66% were NILM and 34% were LSIL OR HSIL. Conclusion: These results establish VIA as an effective screening test for cancerous and precancerous conditions of the cervix and thus VIA can be implemented as a single primary screening method.","publication_date":{"day":1,"month":7,"year":2016,"errors":{}},"publication_name":"International journal of applied research","grobid_abstract_attachment_id":113575503},"translated_abstract":null,"internal_url":"https://www.academia.edu/117807286/Comparison_and_correlation_of_VIA_and_Pap_smear_in_detection_of_precancerous_cervical_lesions","translated_internal_url":"","created_at":"2024-04-20T22:14:10.621-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":69187415,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":113575503,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/113575503/thumbnails/1.jpg","file_name":"2-7-47-181.pdf","download_url":"https://www.academia.edu/attachments/113575503/download_file?st=MTczMzAxNzkyNCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Comparison_and_correlation_of_VIA_and_Pa.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/113575503/2-7-47-181-libre.pdf?1713680396=\u0026response-content-disposition=attachment%3B+filename%3DComparison_and_correlation_of_VIA_and_Pa.pdf\u0026Expires=1733021524\u0026Signature=Dx8OYkkp67flkqhFGtY9jDIYlrEPctuQF6g1MqHOmC4zIi3Vog04w6S2yPDfHp6FqE6cyj3CG99I2OOT2mXNHhwODTY1jRhgpjTCOmaLuCPwgQltSbu5iLIvkKSjG9MkyjRzSSm89r~tUWTtPMF7f2GbwjLYQ7m~jQTBTyQAvZrfiMXyBtROlvIxQtXE033clh29PEbGT6M1DzT4yE1RyfM5vQj~B3z5wRE6tJ8BnB7O9xOfmLZM-LoCseBfP~CtSSpDbTj8FncbHtpblRAB61tLWZzxw4vn9VNG8dKflFP9k~mJKPuZ-PeAys9lT-W5nivrdfRKZs5AQ0XwH55liQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Comparison_and_correlation_of_VIA_and_Pap_smear_in_detection_of_precancerous_cervical_lesions","translated_slug":"","page_count":4,"language":"en","content_type":"Work","owner":{"id":69187415,"first_name":"Girija","middle_initials":null,"last_name":"Wagh","page_name":"GirijaWagh","domain_name":"independent","created_at":"2017-10-08T07:35:52.661-07:00","display_name":"Girija Wagh","url":"https://independent.academia.edu/GirijaWagh"},"attachments":[{"id":113575503,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/113575503/thumbnails/1.jpg","file_name":"2-7-47-181.pdf","download_url":"https://www.academia.edu/attachments/113575503/download_file?st=MTczMzAxNzkyNCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Comparison_and_correlation_of_VIA_and_Pa.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/113575503/2-7-47-181-libre.pdf?1713680396=\u0026response-content-disposition=attachment%3B+filename%3DComparison_and_correlation_of_VIA_and_Pa.pdf\u0026Expires=1733021524\u0026Signature=Dx8OYkkp67flkqhFGtY9jDIYlrEPctuQF6g1MqHOmC4zIi3Vog04w6S2yPDfHp6FqE6cyj3CG99I2OOT2mXNHhwODTY1jRhgpjTCOmaLuCPwgQltSbu5iLIvkKSjG9MkyjRzSSm89r~tUWTtPMF7f2GbwjLYQ7m~jQTBTyQAvZrfiMXyBtROlvIxQtXE033clh29PEbGT6M1DzT4yE1RyfM5vQj~B3z5wRE6tJ8BnB7O9xOfmLZM-LoCseBfP~CtSSpDbTj8FncbHtpblRAB61tLWZzxw4vn9VNG8dKflFP9k~mJKPuZ-PeAys9lT-W5nivrdfRKZs5AQ0XwH55liQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":81504,"name":"Correlation","url":"https://www.academia.edu/Documents/in/Correlation"},{"id":96502,"name":"Applied","url":"https://www.academia.edu/Documents/in/Applied"},{"id":203512,"name":"Cervical Cancer","url":"https://www.academia.edu/Documents/in/Cervical_Cancer"}],"urls":[{"id":41261868,"url":"https://www.allresearchjournal.com/archives/2016/vol2issue7/PartL/2-7-47-181.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="117807285"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/117807285/Region_specific_changes_in_the_mRNA_and_protein_expression_of_LCPUFA_biosynthesis_enzymes_and_transporters_in_the_placentae_of_women_with_preeclampsia"><img alt="Research paper thumbnail of Region-specific changes in the mRNA and protein expression of LCPUFA biosynthesis enzymes and transporters in the placentae of women with preeclampsia" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/117807285/Region_specific_changes_in_the_mRNA_and_protein_expression_of_LCPUFA_biosynthesis_enzymes_and_transporters_in_the_placentae_of_women_with_preeclampsia">Region-specific changes in the mRNA and protein expression of LCPUFA biosynthesis enzymes and transporters in the placentae of women with preeclampsia</a></div><div class="wp-workCard_item"><span>Placenta</span><span>, Jun 1, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The biosynthesis and transport of long chain polyunsaturated fatty acids (LCPUFA) require the act...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The biosynthesis and transport of long chain polyunsaturated fatty acids (LCPUFA) require the activity of fatty acid desaturase (FADS) enzymes, fatty acid transport proteins (FATP) and fatty acid binding proteins (FABP). In a previous study we have demonstrated region-specific changes in the LCPUFA levels in preeclampsia (PE) as compared to the normotensive control (NC) placentae. AIM To understand the region-specific changes in the mRNA levels and protein expression of biosynthesis enzymes and transporters of LCPUFA in PE and NC placentae. METHODS In this cross-sectional study, 20 NC women and 44 women with PE (23 term (TPE) and 21 preterm PE (PTPE)) were recruited. The samples were collected from four regions of the placentae considering cord insertion as the center (CM, central maternal/basal; CF, central fetal/chorionic; PM, peripheral maternal/basal and PF, peripheral fetal/chorionic). The mRNA levels were estimated using qRT-PCR. Statistical analysis was done using both post hoc least significant difference (LSD) test and Benjamini Hochberg correction in the analysis of covariance. Preliminarily, localization and expression of proteins were studied by immunohistochemistry (n = 3/group). RESULTS The mRNA levels of FADS1, FADS2 and FATP1 were lower in the central regions (CM and CF) of the PE placentae (both TPE and PTPE) as compared to NC. These differences in the mRNA levels were observed by the LSD test and were not significant after the Benjamini Hochberg correction. Preliminary findings of IHC indicate that the protein expression of FADS1 and FATP4 was higher in the basal regions (CM and PM) of the PE placentae as compared to NC. FADS1, FADS2 and FATP4 proteins were localized in the syncytiotrophoblasts, cytotrophoblasts, mesenchymal cells, endothelial cells of the fetal capillaries and extravillous trophoblasts of the placenta. CONCLUSION FADS enzymes are detected in the placentae of Indian women. In PE placentae, there are region-specific alterations in the mRNA and protein levels of LCPUFA biosynthesis enzymes (FADS1 and FADS2) and transporters (FATP1, FATP4 and FABP3) as compared to term NC. These changes were more pronounced toward the basal side and region around the cord insertion.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117807285"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117807285"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117807285; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=117807285]").text(description); $(".js-view-count[data-work-id=117807285]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 117807285; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='117807285']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 117807285, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=117807285]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":117807285,"title":"Region-specific changes in the mRNA and protein expression of LCPUFA biosynthesis enzymes and transporters in the placentae of women with preeclampsia","translated_title":"","metadata":{"abstract":"The biosynthesis and transport of long chain polyunsaturated fatty acids (LCPUFA) require the activity of fatty acid desaturase (FADS) enzymes, fatty acid transport proteins (FATP) and fatty acid binding proteins (FABP). In a previous study we have demonstrated region-specific changes in the LCPUFA levels in preeclampsia (PE) as compared to the normotensive control (NC) placentae. AIM To understand the region-specific changes in the mRNA levels and protein expression of biosynthesis enzymes and transporters of LCPUFA in PE and NC placentae. METHODS In this cross-sectional study, 20 NC women and 44 women with PE (23 term (TPE) and 21 preterm PE (PTPE)) were recruited. The samples were collected from four regions of the placentae considering cord insertion as the center (CM, central maternal/basal; CF, central fetal/chorionic; PM, peripheral maternal/basal and PF, peripheral fetal/chorionic). The mRNA levels were estimated using qRT-PCR. Statistical analysis was done using both post hoc least significant difference (LSD) test and Benjamini Hochberg correction in the analysis of covariance. Preliminarily, localization and expression of proteins were studied by immunohistochemistry (n = 3/group). RESULTS The mRNA levels of FADS1, FADS2 and FATP1 were lower in the central regions (CM and CF) of the PE placentae (both TPE and PTPE) as compared to NC. These differences in the mRNA levels were observed by the LSD test and were not significant after the Benjamini Hochberg correction. Preliminary findings of IHC indicate that the protein expression of FADS1 and FATP4 was higher in the basal regions (CM and PM) of the PE placentae as compared to NC. FADS1, FADS2 and FATP4 proteins were localized in the syncytiotrophoblasts, cytotrophoblasts, mesenchymal cells, endothelial cells of the fetal capillaries and extravillous trophoblasts of the placenta. CONCLUSION FADS enzymes are detected in the placentae of Indian women. In PE placentae, there are region-specific alterations in the mRNA and protein levels of LCPUFA biosynthesis enzymes (FADS1 and FADS2) and transporters (FATP1, FATP4 and FABP3) as compared to term NC. These changes were more pronounced toward the basal side and region around the cord insertion.","publisher":"Elsevier BV","publication_date":{"day":1,"month":6,"year":2020,"errors":{}},"publication_name":"Placenta"},"translated_abstract":"The biosynthesis and transport of long chain polyunsaturated fatty acids (LCPUFA) require the activity of fatty acid desaturase (FADS) enzymes, fatty acid transport proteins (FATP) and fatty acid binding proteins (FABP). In a previous study we have demonstrated region-specific changes in the LCPUFA levels in preeclampsia (PE) as compared to the normotensive control (NC) placentae. AIM To understand the region-specific changes in the mRNA levels and protein expression of biosynthesis enzymes and transporters of LCPUFA in PE and NC placentae. METHODS In this cross-sectional study, 20 NC women and 44 women with PE (23 term (TPE) and 21 preterm PE (PTPE)) were recruited. The samples were collected from four regions of the placentae considering cord insertion as the center (CM, central maternal/basal; CF, central fetal/chorionic; PM, peripheral maternal/basal and PF, peripheral fetal/chorionic). The mRNA levels were estimated using qRT-PCR. Statistical analysis was done using both post hoc least significant difference (LSD) test and Benjamini Hochberg correction in the analysis of covariance. Preliminarily, localization and expression of proteins were studied by immunohistochemistry (n = 3/group). RESULTS The mRNA levels of FADS1, FADS2 and FATP1 were lower in the central regions (CM and CF) of the PE placentae (both TPE and PTPE) as compared to NC. These differences in the mRNA levels were observed by the LSD test and were not significant after the Benjamini Hochberg correction. Preliminary findings of IHC indicate that the protein expression of FADS1 and FATP4 was higher in the basal regions (CM and PM) of the PE placentae as compared to NC. FADS1, FADS2 and FATP4 proteins were localized in the syncytiotrophoblasts, cytotrophoblasts, mesenchymal cells, endothelial cells of the fetal capillaries and extravillous trophoblasts of the placenta. CONCLUSION FADS enzymes are detected in the placentae of Indian women. In PE placentae, there are region-specific alterations in the mRNA and protein levels of LCPUFA biosynthesis enzymes (FADS1 and FADS2) and transporters (FATP1, FATP4 and FABP3) as compared to term NC. These changes were more pronounced toward the basal side and region around the cord insertion.","internal_url":"https://www.academia.edu/117807285/Region_specific_changes_in_the_mRNA_and_protein_expression_of_LCPUFA_biosynthesis_enzymes_and_transporters_in_the_placentae_of_women_with_preeclampsia","translated_internal_url":"","created_at":"2024-04-20T22:14:10.316-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":69187415,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Region_specific_changes_in_the_mRNA_and_protein_expression_of_LCPUFA_biosynthesis_enzymes_and_transporters_in_the_placentae_of_women_with_preeclampsia","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":69187415,"first_name":"Girija","middle_initials":null,"last_name":"Wagh","page_name":"GirijaWagh","domain_name":"independent","created_at":"2017-10-08T07:35:52.661-07:00","display_name":"Girija Wagh","url":"https://independent.academia.edu/GirijaWagh"},"attachments":[],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":76061,"name":"Placenta","url":"https://www.academia.edu/Documents/in/Placenta"},{"id":86745,"name":"Preeclampsia","url":"https://www.academia.edu/Documents/in/Preeclampsia"},{"id":231661,"name":"Enzyme","url":"https://www.academia.edu/Documents/in/Enzyme"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":433495,"name":"Biosynthesis","url":"https://www.academia.edu/Documents/in/Biosynthesis"},{"id":568122,"name":"Transporter","url":"https://www.academia.edu/Documents/in/Transporter"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[{"id":41261867,"url":"https://doi.org/10.1016/j.placenta.2020.04.013"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="117807284"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/117807284/Early_Pregnancy_Hemorrhage"><img alt="Research paper thumbnail of Early Pregnancy Hemorrhage" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/117807284/Early_Pregnancy_Hemorrhage">Early Pregnancy Hemorrhage</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117807284"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117807284"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117807284; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=117807284]").text(description); $(".js-view-count[data-work-id=117807284]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 117807284; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='117807284']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 117807284, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=117807284]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":117807284,"title":"Early Pregnancy Hemorrhage","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2018,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/117807284/Early_Pregnancy_Hemorrhage","translated_internal_url":"","created_at":"2024-04-20T22:14:09.992-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":69187415,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Early_Pregnancy_Hemorrhage","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":69187415,"first_name":"Girija","middle_initials":null,"last_name":"Wagh","page_name":"GirijaWagh","domain_name":"independent","created_at":"2017-10-08T07:35:52.661-07:00","display_name":"Girija Wagh","url":"https://independent.academia.edu/GirijaWagh","email":"MkNVdzhxNFQ5aUZTRjRRZTlQNGR1Q1lWcDgvSFo2Y1RtaTc3bE5uRTQ5RT0tLWtVdUMwUkFkMHNyLzNKVkszYWY1cVE9PQ==--a35574ea5e65e3565ec17f5f4cf38be6b92dd466"},"attachments":[],"research_interests":[{"id":625,"name":"Obstetrics","url":"https://www.academia.edu/Documents/in/Obstetrics"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy"}],"urls":[{"id":41261866,"url":"https://doi.org/10.5005/jp/books/14143_16"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="117807282"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/117807282/Placental_DHA_and_mRNA_levels_of_PPAR%CE%B3_and_LXR%CE%B1_and_their_relationship_to_birth_weight"><img alt="Research paper thumbnail of Placental DHA and mRNA levels of PPARγ and LXRα and their relationship to birth weight" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/117807282/Placental_DHA_and_mRNA_levels_of_PPAR%CE%B3_and_LXR%CE%B1_and_their_relationship_to_birth_weight">Placental DHA and mRNA levels of PPARγ and LXRα and their relationship to birth weight</a></div><div class="wp-workCard_item"><span>Journal of Clinical Lipidology</span><span>, Jul 1, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A very large number of fatty acids play wide range of physiological roles in cellular growth and ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A very large number of fatty acids play wide range of physiological roles in cellular growth and function in placental as well as fetal growth. However, docosahexaenoic acid (DHA), in addition to its critical role in cellular membranes, is known to act as a ligand for several nuclear receptors and regulates the activity of transcription factor families like peroxisome proliferator-activated receptor, liver X receptor (LXR), retinoid X receptor (RXR), and sterol regulatory element binding protein (SREBP). These transcription factors and DHA are known to regulate the placental and fetal growth and development. The objective of the present study was to examine the fatty acids and transcription factors in the placenta of women delivering low birth weight (LBW) babies. The present study examines the fatty acid and mRNA levels of various transcription factors in the placentae of women delivering normal birth weight (NBW) (n = 38) and women delivering LBW (n = 36). Placental fatty acids were analyzed using gas chromatography. Placental mRNA levels of PPARα, PPARγ, SREBP-1c, LXRα, RXRα, and RXRγ were examined using quantitative real time PCR. Placental DHA levels and mRNA levels of placental PPARγ and LXRα were lower (P &amp;amp;amp;lt; .05 for all) in women delivering LBW babies. There was a positive association of placental PPARγ mRNA levels and placental DHA levels with baby weight (P &amp;amp;amp;lt; .05 for both). Our data suggest that lower placental DHA and transcription factors may have a vital role in the etiology of LBW babies.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117807282"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117807282"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117807282; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=117807282]").text(description); $(".js-view-count[data-work-id=117807282]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 117807282; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='117807282']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 117807282, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=117807282]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":117807282,"title":"Placental DHA and mRNA levels of PPARγ and LXRα and their relationship to birth weight","translated_title":"","metadata":{"abstract":"A very large number of fatty acids play wide range of physiological roles in cellular growth and function in placental as well as fetal growth. However, docosahexaenoic acid (DHA), in addition to its critical role in cellular membranes, is known to act as a ligand for several nuclear receptors and regulates the activity of transcription factor families like peroxisome proliferator-activated receptor, liver X receptor (LXR), retinoid X receptor (RXR), and sterol regulatory element binding protein (SREBP). These transcription factors and DHA are known to regulate the placental and fetal growth and development. The objective of the present study was to examine the fatty acids and transcription factors in the placenta of women delivering low birth weight (LBW) babies. The present study examines the fatty acid and mRNA levels of various transcription factors in the placentae of women delivering normal birth weight (NBW) (n = 38) and women delivering LBW (n = 36). Placental fatty acids were analyzed using gas chromatography. Placental mRNA levels of PPARα, PPARγ, SREBP-1c, LXRα, RXRα, and RXRγ were examined using quantitative real time PCR. Placental DHA levels and mRNA levels of placental PPARγ and LXRα were lower (P \u0026amp;amp;amp;lt; .05 for all) in women delivering LBW babies. There was a positive association of placental PPARγ mRNA levels and placental DHA levels with baby weight (P \u0026amp;amp;amp;lt; .05 for both). Our data suggest that lower placental DHA and transcription factors may have a vital role in the etiology of LBW babies.","publisher":"Elsevier BV","publication_date":{"day":1,"month":7,"year":2016,"errors":{}},"publication_name":"Journal of Clinical Lipidology"},"translated_abstract":"A very large number of fatty acids play wide range of physiological roles in cellular growth and function in placental as well as fetal growth. 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Placental mRNA levels of PPARα, PPARγ, SREBP-1c, LXRα, RXRα, and RXRγ were examined using quantitative real time PCR. Placental DHA levels and mRNA levels of placental PPARγ and LXRα were lower (P \u0026amp;amp;amp;lt; .05 for all) in women delivering LBW babies. There was a positive association of placental PPARγ mRNA levels and placental DHA levels with baby weight (P \u0026amp;amp;amp;lt; .05 for both). Our data suggest that lower placental DHA and transcription factors may have a vital role in the etiology of LBW babies.","internal_url":"https://www.academia.edu/117807282/Placental_DHA_and_mRNA_levels_of_PPAR%CE%B3_and_LXR%CE%B1_and_their_relationship_to_birth_weight","translated_internal_url":"","created_at":"2024-04-20T22:14:09.610-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":69187415,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Placental_DHA_and_mRNA_levels_of_PPARγ_and_LXRα_and_their_relationship_to_birth_weight","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":69187415,"first_name":"Girija","middle_initials":null,"last_name":"Wagh","page_name":"GirijaWagh","domain_name":"independent","created_at":"2017-10-08T07:35:52.661-07:00","display_name":"Girija Wagh","url":"https://independent.academia.edu/GirijaWagh"},"attachments":[],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":23323,"name":"Transcription Factors","url":"https://www.academia.edu/Documents/in/Transcription_Factors"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":47155,"name":"Birth Weight","url":"https://www.academia.edu/Documents/in/Birth_Weight"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":76061,"name":"Placenta","url":"https://www.academia.edu/Documents/in/Placenta"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult"},{"id":170483,"name":"Peroxisome proliferator-activated receptor","url":"https://www.academia.edu/Documents/in/Peroxisome_proliferator-activated_receptor"},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant"},{"id":770944,"name":"Fetus","url":"https://www.academia.edu/Documents/in/Fetus"},{"id":1611350,"name":"Docosahexaenoic Acid","url":"https://www.academia.edu/Documents/in/Docosahexaenoic_Acid"},{"id":1643369,"name":"retinoid X receptor","url":"https://www.academia.edu/Documents/in/retinoid_X_receptor"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology"},{"id":3789880,"name":"Medical biochemistry and metabolomics","url":"https://www.academia.edu/Documents/in/Medical_biochemistry_and_metabolomics"}],"urls":[{"id":41261864,"url":"https://doi.org/10.1016/j.jacl.2016.02.004"}]}, dispatcherData: dispatcherData }); 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transporters in syncytiotrophoblast membranes in preeclampsia placentae" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/117807292/Altered_expression_of_nutrient_transporters_in_syncytiotrophoblast_membranes_in_preeclampsia_placentae">Altered expression of nutrient transporters in syncytiotrophoblast membranes in preeclampsia placentae</a></div><div class="wp-workCard_item"><span>Placenta</span><span>, Aug 1, 2023</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper 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class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/117807291/Effect_of_combination_of_Curcuma_longa_with_Emblica_officinalis_in_females_with_polycystic_ovarian_syndrome_An_open_label_randomized_active_controlled_exploratory_clinical_study">Effect of combination of Curcuma longa with Emblica officinalis in females with polycystic ovarian syndrome: An open-label, randomized active-controlled, exploratory clinical study</a></div><div class="wp-workCard_item"><span>Journal of Diabetology : Official Journal of Diabetes in Asia Study Group</span><span>, 2023</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Introduction: Polycystic ovarian syndrome (PCOS) is the commonest cause of infertility due to ano...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Introduction: Polycystic ovarian syndrome (PCOS) is the commonest cause of infertility due to anovulation. The combination of Curcuma longa (CL) and Emblica officinalis (EO) is known to ameliorate diabetes and, thereby, may resurrect PCOS. The present study aimed to evaluate the effect of this combination prepared by two different methods, independently and with metformin (Met), compared with Met in PCOS on glycaemic control, inflammation, adipokines, and anthropometry. Aim: The aim of the study was to evaluate the effect of the combination of CL and EO, prepared by two different methods, independently and with Met, compared with Met in PCOS. Materials and Methods: PCOS women aged 18–35 years were selected through Rotterdam criteria from a tertiary care teaching hospital setting post-Ethics Committee permission. They were randomized to five groups (eight per group); combination of CL and EO prepared by traditional method (TF- Traditional Formulation), standardized extraction method (PNAE- Pharmanza Nisha Amalaki Extract), standard control Metformin (Met) and their combinations, TF + Met and PNAE + Met for 90 days. Fasting glucose, insulin, lipid profile, reproductive hormones (luteinizing hormone [LH], follicle-stimulating hormone [FSH], and free testosterone), inflammatory markers (tumor necrosis factor-alpha [TNF-α], interleukin [IL]-6), and adipokines (leptin and adiponectin) were done at baseline and day 90, whereas anthropometry was done monthly. Results: Of 48 randomized women, 37 completed the study. TF and Met groups demonstrated higher weight decrease, whereas TF + Met significantly decreased waist circumference. Blood glucose, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) decreased in all groups except glucose in TF + Met and HOMA-IR in the Met group. Only PNAE decreased free testosterone. TNF-α increased while leptin decreased in all groups. Both TF and PNAE, with Met reduced IL 6, significantly only in PNAE + Met group. Similarly, both TF and PNAE, with Met reduced LH/FSH ratio and significantly increased adiponectin. Two females, each, conceived in TF and PNAE, whereas one was in PNAE + Met group. No adverse events were reported. Conclusion: Both botanical formulations, TF and PNAE, were comparable to Met. The standardized extracts formulation PNAE seems more promising due to administration ease, smaller dose, and consistent bioactives.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117807291"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117807291"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117807291; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=117807291]").text(description); $(".js-view-count[data-work-id=117807291]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 117807291; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='117807291']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 117807291, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=117807291]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":117807291,"title":"Effect of combination of Curcuma longa with Emblica officinalis in females with polycystic ovarian syndrome: An open-label, randomized active-controlled, exploratory clinical study","translated_title":"","metadata":{"abstract":"Introduction: Polycystic ovarian syndrome (PCOS) is the commonest cause of infertility due to anovulation. The combination of Curcuma longa (CL) and Emblica officinalis (EO) is known to ameliorate diabetes and, thereby, may resurrect PCOS. The present study aimed to evaluate the effect of this combination prepared by two different methods, independently and with metformin (Met), compared with Met in PCOS on glycaemic control, inflammation, adipokines, and anthropometry. Aim: The aim of the study was to evaluate the effect of the combination of CL and EO, prepared by two different methods, independently and with Met, compared with Met in PCOS. Materials and Methods: PCOS women aged 18–35 years were selected through Rotterdam criteria from a tertiary care teaching hospital setting post-Ethics Committee permission. They were randomized to five groups (eight per group); combination of CL and EO prepared by traditional method (TF- Traditional Formulation), standardized extraction method (PNAE- Pharmanza Nisha Amalaki Extract), standard control Metformin (Met) and their combinations, TF + Met and PNAE + Met for 90 days. Fasting glucose, insulin, lipid profile, reproductive hormones (luteinizing hormone [LH], follicle-stimulating hormone [FSH], and free testosterone), inflammatory markers (tumor necrosis factor-alpha [TNF-α], interleukin [IL]-6), and adipokines (leptin and adiponectin) were done at baseline and day 90, whereas anthropometry was done monthly. Results: Of 48 randomized women, 37 completed the study. TF and Met groups demonstrated higher weight decrease, whereas TF + Met significantly decreased waist circumference. Blood glucose, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) decreased in all groups except glucose in TF + Met and HOMA-IR in the Met group. Only PNAE decreased free testosterone. TNF-α increased while leptin decreased in all groups. Both TF and PNAE, with Met reduced IL 6, significantly only in PNAE + Met group. Similarly, both TF and PNAE, with Met reduced LH/FSH ratio and significantly increased adiponectin. Two females, each, conceived in TF and PNAE, whereas one was in PNAE + Met group. No adverse events were reported. Conclusion: Both botanical formulations, TF and PNAE, were comparable to Met. The standardized extracts formulation PNAE seems more promising due to administration ease, smaller dose, and consistent bioactives.","publisher":"Medknow","publication_date":{"day":null,"month":null,"year":2023,"errors":{}},"publication_name":"Journal of Diabetology : Official Journal of Diabetes in Asia Study Group"},"translated_abstract":"Introduction: Polycystic ovarian syndrome (PCOS) is the commonest cause of infertility due to anovulation. The combination of Curcuma longa (CL) and Emblica officinalis (EO) is known to ameliorate diabetes and, thereby, may resurrect PCOS. The present study aimed to evaluate the effect of this combination prepared by two different methods, independently and with metformin (Met), compared with Met in PCOS on glycaemic control, inflammation, adipokines, and anthropometry. Aim: The aim of the study was to evaluate the effect of the combination of CL and EO, prepared by two different methods, independently and with Met, compared with Met in PCOS. Materials and Methods: PCOS women aged 18–35 years were selected through Rotterdam criteria from a tertiary care teaching hospital setting post-Ethics Committee permission. They were randomized to five groups (eight per group); combination of CL and EO prepared by traditional method (TF- Traditional Formulation), standardized extraction method (PNAE- Pharmanza Nisha Amalaki Extract), standard control Metformin (Met) and their combinations, TF + Met and PNAE + Met for 90 days. Fasting glucose, insulin, lipid profile, reproductive hormones (luteinizing hormone [LH], follicle-stimulating hormone [FSH], and free testosterone), inflammatory markers (tumor necrosis factor-alpha [TNF-α], interleukin [IL]-6), and adipokines (leptin and adiponectin) were done at baseline and day 90, whereas anthropometry was done monthly. Results: Of 48 randomized women, 37 completed the study. TF and Met groups demonstrated higher weight decrease, whereas TF + Met significantly decreased waist circumference. Blood glucose, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR) decreased in all groups except glucose in TF + Met and HOMA-IR in the Met group. Only PNAE decreased free testosterone. TNF-α increased while leptin decreased in all groups. Both TF and PNAE, with Met reduced IL 6, significantly only in PNAE + Met group. Similarly, both TF and PNAE, with Met reduced LH/FSH ratio and significantly increased adiponectin. Two females, each, conceived in TF and PNAE, whereas one was in PNAE + Met group. No adverse events were reported. Conclusion: Both botanical formulations, TF and PNAE, were comparable to Met. The standardized extracts formulation PNAE seems more promising due to administration ease, smaller dose, and consistent bioactives.","internal_url":"https://www.academia.edu/117807291/Effect_of_combination_of_Curcuma_longa_with_Emblica_officinalis_in_females_with_polycystic_ovarian_syndrome_An_open_label_randomized_active_controlled_exploratory_clinical_study","translated_internal_url":"","created_at":"2024-04-20T22:14:15.091-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":69187415,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Effect_of_combination_of_Curcuma_longa_with_Emblica_officinalis_in_females_with_polycystic_ovarian_syndrome_An_open_label_randomized_active_controlled_exploratory_clinical_study","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":69187415,"first_name":"Girija","middle_initials":null,"last_name":"Wagh","page_name":"GirijaWagh","domain_name":"independent","created_at":"2017-10-08T07:35:52.661-07:00","display_name":"Girija Wagh","url":"https://independent.academia.edu/GirijaWagh"},"attachments":[],"research_interests":[{"id":614,"name":"Diabetology","url":"https://www.academia.edu/Documents/in/Diabetology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":51373,"name":"Insulin Resistance","url":"https://www.academia.edu/Documents/in/Insulin_Resistance"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"}],"urls":[{"id":41261872,"url":"https://doi.org/10.4103/jod.jod_17_23"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="117807290"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/117807290/Comparison_and_correlation_of_visual_inspection_with_acetic_acid_papanicolaou_smear_and_colposcopy_in_detection_of_precancerous_cervical_lesions"><img alt="Research paper thumbnail of Comparison and correlation of visual inspection with acetic acid, papanicolaou smear and colposcopy in detection of precancerous cervical lesions" class="work-thumbnail" src="https://attachments.academia-assets.com/113575504/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/117807290/Comparison_and_correlation_of_visual_inspection_with_acetic_acid_papanicolaou_smear_and_colposcopy_in_detection_of_precancerous_cervical_lesions">Comparison and correlation of visual inspection with acetic acid, papanicolaou smear and colposcopy in detection of precancerous cervical lesions</a></div><div class="wp-workCard_item"><span>International journal of reproduction, contraception, obstetrics and gynecology</span><span>, 2016</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="78741f077fa6ab31b211fc45a2064f03" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":113575504,"asset_id":117807290,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/113575504/download_file?st=MTczMzAxNzkyNSw4LjIyMi4yMDguMTQ2&st=MTczMzAxNzkyNCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117807290"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117807290"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117807290; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=117807290]").text(description); $(".js-view-count[data-work-id=117807290]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 117807290; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='117807290']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 117807290, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "78741f077fa6ab31b211fc45a2064f03" } } $('.js-work-strip[data-work-id=117807290]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":117807290,"title":"Comparison and correlation of visual inspection with acetic acid, papanicolaou smear and colposcopy in detection of precancerous cervical lesions","translated_title":"","metadata":{"publisher":"Medip Academy","grobid_abstract":"Cervical cancer has huge burden on national health system. 1,2 Cervical cancer kills approximately 230,000 women annually, with the vast majority of deaths occurring in developing countries. Worldwide, cervical carcinoma is the fifth most common cancer-related cause of death among women in the developing world; it is the leading cause of cancer death in women. 1 Global distribution of cervical cancer varies, with Africa, Asia, and Latin America bearing a substantial burden of this disease. 1,2 Cervical cancer prevention programs in both developed and developing nations generally have relied on cytological testing using the papanicolaou (Pap) smear test. Such screening programs can be expensive, prone to error, and logistically difficult to implement particularly in developing countries.","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"International journal of reproduction, contraception, obstetrics and gynecology","grobid_abstract_attachment_id":113575504},"translated_abstract":null,"internal_url":"https://www.academia.edu/117807290/Comparison_and_correlation_of_visual_inspection_with_acetic_acid_papanicolaou_smear_and_colposcopy_in_detection_of_precancerous_cervical_lesions","translated_internal_url":"","created_at":"2024-04-20T22:14:14.819-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":69187415,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":113575504,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/113575504/thumbnails/1.jpg","file_name":"399.pdf","download_url":"https://www.academia.edu/attachments/113575504/download_file?st=MTczMzAxNzkyNSw4LjIyMi4yMDguMTQ2&st=MTczMzAxNzkyNCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Comparison_and_correlation_of_visual_ins.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/113575504/399-libre.pdf?1713680398=\u0026response-content-disposition=attachment%3B+filename%3DComparison_and_correlation_of_visual_ins.pdf\u0026Expires=1733021524\u0026Signature=bwZJ7vaH-hmXDoSM92ibe3jW4iwByV-wzohj3MwTRnUCcQTr9K2aHOf6oVGX4nZ2Wlc507MgiwOee2gLciUzlWlvU8~t6FhhWNQjaitDp-aCVCuNqGSHwj7nNBixFJtoyz2enZon6qgkBNx53B4Ve1588gWjHcJCA6fUmEezrgxU3UM86Bn5Z-0ljjkLIVaL3QtnSjHeECd91M6bqawmbQ~lAG-nELC17YWlsSaXXARxGCgZkoVL5OT5FDJ6qJTNH4WTYnd2hoDlXYUDfaN0AaspSdmlRdCnAzgd-b7gq8OF1DlJIQm9Eh4~b9u9YdZ5xrbzwpOXatgixG2YEZMR~Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Comparison_and_correlation_of_visual_inspection_with_acetic_acid_papanicolaou_smear_and_colposcopy_in_detection_of_precancerous_cervical_lesions","translated_slug":"","page_count":6,"language":"en","content_type":"Work","owner":{"id":69187415,"first_name":"Girija","middle_initials":null,"last_name":"Wagh","page_name":"GirijaWagh","domain_name":"independent","created_at":"2017-10-08T07:35:52.661-07:00","display_name":"Girija Wagh","url":"https://independent.academia.edu/GirijaWagh"},"attachments":[{"id":113575504,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/113575504/thumbnails/1.jpg","file_name":"399.pdf","download_url":"https://www.academia.edu/attachments/113575504/download_file?st=MTczMzAxNzkyNSw4LjIyMi4yMDguMTQ2&st=MTczMzAxNzkyNCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Comparison_and_correlation_of_visual_ins.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/113575504/399-libre.pdf?1713680398=\u0026response-content-disposition=attachment%3B+filename%3DComparison_and_correlation_of_visual_ins.pdf\u0026Expires=1733021524\u0026Signature=bwZJ7vaH-hmXDoSM92ibe3jW4iwByV-wzohj3MwTRnUCcQTr9K2aHOf6oVGX4nZ2Wlc507MgiwOee2gLciUzlWlvU8~t6FhhWNQjaitDp-aCVCuNqGSHwj7nNBixFJtoyz2enZon6qgkBNx53B4Ve1588gWjHcJCA6fUmEezrgxU3UM86Bn5Z-0ljjkLIVaL3QtnSjHeECd91M6bqawmbQ~lAG-nELC17YWlsSaXXARxGCgZkoVL5OT5FDJ6qJTNH4WTYnd2hoDlXYUDfaN0AaspSdmlRdCnAzgd-b7gq8OF1DlJIQm9Eh4~b9u9YdZ5xrbzwpOXatgixG2YEZMR~Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":625,"name":"Obstetrics","url":"https://www.academia.edu/Documents/in/Obstetrics"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":195979,"name":"Colposcopy","url":"https://www.academia.edu/Documents/in/Colposcopy"},{"id":203512,"name":"Cervical Cancer","url":"https://www.academia.edu/Documents/in/Cervical_Cancer"},{"id":339107,"name":"Gynecology","url":"https://www.academia.edu/Documents/in/Gynecology"},{"id":1355484,"name":"Cervix","url":"https://www.academia.edu/Documents/in/Cervix"}],"urls":[{"id":41261871,"url":"https://www.ijrcog.org/index.php/ijrcog/article/download/417/399"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="117807289"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/117807289/Evaluate_the_Feasibility_of_Surgical_Transversus_Abdominis_Plane_Block_for_Postoperative_Analgesia_After_Cesarean_Section"><img alt="Research paper thumbnail of Evaluate the Feasibility of Surgical Transversus Abdominis Plane Block for Postoperative Analgesia After Cesarean Section" class="work-thumbnail" src="https://attachments.academia-assets.com/113575533/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/117807289/Evaluate_the_Feasibility_of_Surgical_Transversus_Abdominis_Plane_Block_for_Postoperative_Analgesia_After_Cesarean_Section">Evaluate the Feasibility of Surgical Transversus Abdominis Plane Block for Postoperative Analgesia After Cesarean Section</a></div><div class="wp-workCard_item"><span>The Journal of Obstetrics and Gynecology of India</span><span>, Jun 8, 2019</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BackgroundTransversus abdominis plane (TAP) block is a fascial plane block providing postoperativ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BackgroundTransversus abdominis plane (TAP) block is a fascial plane block providing postoperative analgesia after lower abdominal surgeries including Cesarean section. Conventionally, it is administered under ultrasound guidance or by blind technique. We studied a novel transperitoneal surgical TAP block for providing safe and effective analgesia after Cesarean section through transverse incision.MethodsA hundred patients who fulfilled the inclusion criteria were included in the study after obtaining informed written consent. They were randomized in two groups: Group A with surgical TAP block and Group B without TAP block as control. Surgical TAP block was administered by transperitoneal route before the closure of peritoneum with 0.25% bupivacaine (dose adjusted with weight of the patient), and visual analogue score was assessed by a blind assessor. Time for rescue analgesia was noted and analyzed with the ‘two independent sample t test.’ResultsThe duration of postoperative analgesia in hours was significantly longer in the TAP block group compared with the control group (5.14 ± 1.63 vs 2.61 ± 0.89, p < 0.001). There was no reported complication of the surgical technique or any adverse effect of the used drug.ConclusionSurgical TAP block via the transperitoneal route is a safe, easy and effective mode of providing postoperative analgesia after Cesarean section. This technique does not need any costly specialist equipment, overcomes the technical limitations of ultrasound-guided TAP block and can be used in obese patients also. It has almost no side effects, and the technique can be easily mastered.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="8396a38608e6cfca9bbe97e3444fa2fd" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":113575533,"asset_id":117807289,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/113575533/download_file?st=MTczMzAxNzkyNSw4LjIyMi4yMDguMTQ2&st=MTczMzAxNzkyNCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117807289"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117807289"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117807289; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=117807289]").text(description); $(".js-view-count[data-work-id=117807289]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 117807289; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='117807289']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 117807289, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "8396a38608e6cfca9bbe97e3444fa2fd" } } $('.js-work-strip[data-work-id=117807289]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":117807289,"title":"Evaluate the Feasibility of Surgical Transversus Abdominis Plane Block for Postoperative Analgesia After Cesarean Section","translated_title":"","metadata":{"abstract":"BackgroundTransversus abdominis plane (TAP) block is a fascial plane block providing postoperative analgesia after lower abdominal surgeries including Cesarean section. Conventionally, it is administered under ultrasound guidance or by blind technique. We studied a novel transperitoneal surgical TAP block for providing safe and effective analgesia after Cesarean section through transverse incision.MethodsA hundred patients who fulfilled the inclusion criteria were included in the study after obtaining informed written consent. They were randomized in two groups: Group A with surgical TAP block and Group B without TAP block as control. Surgical TAP block was administered by transperitoneal route before the closure of peritoneum with 0.25% bupivacaine (dose adjusted with weight of the patient), and visual analogue score was assessed by a blind assessor. Time for rescue analgesia was noted and analyzed with the ‘two independent sample t test.’ResultsThe duration of postoperative analgesia in hours was significantly longer in the TAP block group compared with the control group (5.14 ± 1.63 vs 2.61 ± 0.89, p \u003c 0.001). There was no reported complication of the surgical technique or any adverse effect of the used drug.ConclusionSurgical TAP block via the transperitoneal route is a safe, easy and effective mode of providing postoperative analgesia after Cesarean section. This technique does not need any costly specialist equipment, overcomes the technical limitations of ultrasound-guided TAP block and can be used in obese patients also. It has almost no side effects, and the technique can be easily mastered.","publisher":"Springer Science+Business Media","publication_date":{"day":8,"month":6,"year":2019,"errors":{}},"publication_name":"The Journal of Obstetrics and Gynecology of India"},"translated_abstract":"BackgroundTransversus abdominis plane (TAP) block is a fascial plane block providing postoperative analgesia after lower abdominal surgeries including Cesarean section. Conventionally, it is administered under ultrasound guidance or by blind technique. We studied a novel transperitoneal surgical TAP block for providing safe and effective analgesia after Cesarean section through transverse incision.MethodsA hundred patients who fulfilled the inclusion criteria were included in the study after obtaining informed written consent. They were randomized in two groups: Group A with surgical TAP block and Group B without TAP block as control. Surgical TAP block was administered by transperitoneal route before the closure of peritoneum with 0.25% bupivacaine (dose adjusted with weight of the patient), and visual analogue score was assessed by a blind assessor. Time for rescue analgesia was noted and analyzed with the ‘two independent sample t test.’ResultsThe duration of postoperative analgesia in hours was significantly longer in the TAP block group compared with the control group (5.14 ± 1.63 vs 2.61 ± 0.89, p \u003c 0.001). There was no reported complication of the surgical technique or any adverse effect of the used drug.ConclusionSurgical TAP block via the transperitoneal route is a safe, easy and effective mode of providing postoperative analgesia after Cesarean section. This technique does not need any costly specialist equipment, overcomes the technical limitations of ultrasound-guided TAP block and can be used in obese patients also. It has almost no side effects, and the technique can be easily mastered.","internal_url":"https://www.academia.edu/117807289/Evaluate_the_Feasibility_of_Surgical_Transversus_Abdominis_Plane_Block_for_Postoperative_Analgesia_After_Cesarean_Section","translated_internal_url":"","created_at":"2024-04-20T22:14:14.396-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":69187415,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":113575533,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/113575533/thumbnails/1.jpg","file_name":"s13224-019-01241-320240421-1-c0vzop.pdf","download_url":"https://www.academia.edu/attachments/113575533/download_file?st=MTczMzAxNzkyNSw4LjIyMi4yMDguMTQ2&st=MTczMzAxNzkyNCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Evaluate_the_Feasibility_of_Surgical_Tra.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/113575533/s13224-019-01241-320240421-1-c0vzop-libre.pdf?1713680388=\u0026response-content-disposition=attachment%3B+filename%3DEvaluate_the_Feasibility_of_Surgical_Tra.pdf\u0026Expires=1733021524\u0026Signature=edLS0GKuqtwGpbkHFOBjvhf4RttXeaRqGV5TVpPPKvxfG79LQugNbJ26-vBe~yYYTjA9qQiQzOq8Hq7WCnEPnB~A75Gsut0GSoqHTPVupiQsWMsKo-I34HKYc6MBo~kBvN2sGFXvHJhEX3v1taI3P3Lzz3gqlS1Os~Pzni~MbrC9UWRDbT5oBigQQyF2MpFr1~Gn2iuGLzjDGo30ez8D8iJPUhiu2TM254ph1H8ZyFS8WnYDCLAaJPijqpO-jJHOOy3~8ptl~OFjCVs8x13pQKTZ~AJMRuTg8k425FZ8TZCKJLElyulChUr2jeu9JyOfs~sKFjoVMXn3CKapokQHHQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Evaluate_the_Feasibility_of_Surgical_Transversus_Abdominis_Plane_Block_for_Postoperative_Analgesia_After_Cesarean_Section","translated_slug":"","page_count":4,"language":"en","content_type":"Work","owner":{"id":69187415,"first_name":"Girija","middle_initials":null,"last_name":"Wagh","page_name":"GirijaWagh","domain_name":"independent","created_at":"2017-10-08T07:35:52.661-07:00","display_name":"Girija Wagh","url":"https://independent.academia.edu/GirijaWagh"},"attachments":[{"id":113575533,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/113575533/thumbnails/1.jpg","file_name":"s13224-019-01241-320240421-1-c0vzop.pdf","download_url":"https://www.academia.edu/attachments/113575533/download_file?st=MTczMzAxNzkyNSw4LjIyMi4yMDguMTQ2&st=MTczMzAxNzkyNCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Evaluate_the_Feasibility_of_Surgical_Tra.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/113575533/s13224-019-01241-320240421-1-c0vzop-libre.pdf?1713680388=\u0026response-content-disposition=attachment%3B+filename%3DEvaluate_the_Feasibility_of_Surgical_Tra.pdf\u0026Expires=1733021524\u0026Signature=edLS0GKuqtwGpbkHFOBjvhf4RttXeaRqGV5TVpPPKvxfG79LQugNbJ26-vBe~yYYTjA9qQiQzOq8Hq7WCnEPnB~A75Gsut0GSoqHTPVupiQsWMsKo-I34HKYc6MBo~kBvN2sGFXvHJhEX3v1taI3P3Lzz3gqlS1Os~Pzni~MbrC9UWRDbT5oBigQQyF2MpFr1~Gn2iuGLzjDGo30ez8D8iJPUhiu2TM254ph1H8ZyFS8WnYDCLAaJPijqpO-jJHOOy3~8ptl~OFjCVs8x13pQKTZ~AJMRuTg8k425FZ8TZCKJLElyulChUr2jeu9JyOfs~sKFjoVMXn3CKapokQHHQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":647,"name":"Surgery","url":"https://www.academia.edu/Documents/in/Surgery"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":129739,"name":"Anesthesia","url":"https://www.academia.edu/Documents/in/Anesthesia"},{"id":413196,"name":"Randomized Controlled Trial","url":"https://www.academia.edu/Documents/in/Randomized_Controlled_Trial"},{"id":2560488,"name":"Bupivacaine","url":"https://www.academia.edu/Documents/in/Bupivacaine"}],"urls":[{"id":41261870,"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6661045"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="117807287"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/117807287/Association_between_proNGF_receptors_and_apoptotic_factors_in_human_placentae"><img alt="Research paper thumbnail of Association between proNGF receptors and apoptotic factors in human placentae" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/117807287/Association_between_proNGF_receptors_and_apoptotic_factors_in_human_placentae">Association between proNGF receptors and apoptotic factors in human placentae</a></div><div class="wp-workCard_item"><span>Placenta</span><span>, Aug 1, 2023</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117807287"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117807287"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117807287; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="117807286"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/117807286/Comparison_and_correlation_of_VIA_and_Pap_smear_in_detection_of_precancerous_cervical_lesions"><img alt="Research paper thumbnail of Comparison and correlation of VIA and Pap smear in detection of precancerous cervical lesions" class="work-thumbnail" src="https://attachments.academia-assets.com/113575503/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/117807286/Comparison_and_correlation_of_VIA_and_Pap_smear_in_detection_of_precancerous_cervical_lesions">Comparison and correlation of VIA and Pap smear in detection of precancerous cervical lesions</a></div><div class="wp-workCard_item"><span>International journal of applied research</span><span>, Jul 1, 2016</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d05ca02bb3fb95742cc3d233aeec37ee" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":113575503,"asset_id":117807286,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/113575503/download_file?st=MTczMzAxNzkyNSw4LjIyMi4yMDguMTQ2&st=MTczMzAxNzkyNCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117807286"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117807286"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117807286; 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To curb the disease, there is a need to develop a screening test that has good sensitivity and specificity. The present study is aimed to compare the effectiveness of the Pap smear, Visual Inspection with Acetic Acid (VIA) for mass screening of premalignant and malignant lesions of the cervix. Aims and objectives: 1. To screen women of 30-45 yrs. for precancerous or cancerous lesions of the cervix with VIA and Pap smear. 2. To compare and correlate the findings of Pap smear and VIA in detecting precancerous lesions of cervix. Material and Methods: This was a prospective observational study conducted from 01/01/2015 in the Department of Obstetrics and Gynaecology among 200 women of 30-45 yrs. of age group. Pap smear was performed by the conventional method and VIA was carried out for all. Results: The study group consisting of 200 women, 69% women were VIA negative and 31% were VIA positive. Out of 69% VIA negative patients pap results were supporting its interpretation as all pap tests were negative for precancerous and cancerous lesions of cervix. Out of VIA positive patients 66% were NILM and 34% were LSIL OR HSIL. Conclusion: These results establish VIA as an effective screening test for cancerous and precancerous conditions of the cervix and thus VIA can be implemented as a single primary screening method.","publication_date":{"day":1,"month":7,"year":2016,"errors":{}},"publication_name":"International journal of applied research","grobid_abstract_attachment_id":113575503},"translated_abstract":null,"internal_url":"https://www.academia.edu/117807286/Comparison_and_correlation_of_VIA_and_Pap_smear_in_detection_of_precancerous_cervical_lesions","translated_internal_url":"","created_at":"2024-04-20T22:14:10.621-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":69187415,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":113575503,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/113575503/thumbnails/1.jpg","file_name":"2-7-47-181.pdf","download_url":"https://www.academia.edu/attachments/113575503/download_file?st=MTczMzAxNzkyNSw4LjIyMi4yMDguMTQ2&st=MTczMzAxNzkyNCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Comparison_and_correlation_of_VIA_and_Pa.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/113575503/2-7-47-181-libre.pdf?1713680396=\u0026response-content-disposition=attachment%3B+filename%3DComparison_and_correlation_of_VIA_and_Pa.pdf\u0026Expires=1733021524\u0026Signature=Dx8OYkkp67flkqhFGtY9jDIYlrEPctuQF6g1MqHOmC4zIi3Vog04w6S2yPDfHp6FqE6cyj3CG99I2OOT2mXNHhwODTY1jRhgpjTCOmaLuCPwgQltSbu5iLIvkKSjG9MkyjRzSSm89r~tUWTtPMF7f2GbwjLYQ7m~jQTBTyQAvZrfiMXyBtROlvIxQtXE033clh29PEbGT6M1DzT4yE1RyfM5vQj~B3z5wRE6tJ8BnB7O9xOfmLZM-LoCseBfP~CtSSpDbTj8FncbHtpblRAB61tLWZzxw4vn9VNG8dKflFP9k~mJKPuZ-PeAys9lT-W5nivrdfRKZs5AQ0XwH55liQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Comparison_and_correlation_of_VIA_and_Pap_smear_in_detection_of_precancerous_cervical_lesions","translated_slug":"","page_count":4,"language":"en","content_type":"Work","owner":{"id":69187415,"first_name":"Girija","middle_initials":null,"last_name":"Wagh","page_name":"GirijaWagh","domain_name":"independent","created_at":"2017-10-08T07:35:52.661-07:00","display_name":"Girija Wagh","url":"https://independent.academia.edu/GirijaWagh"},"attachments":[{"id":113575503,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/113575503/thumbnails/1.jpg","file_name":"2-7-47-181.pdf","download_url":"https://www.academia.edu/attachments/113575503/download_file?st=MTczMzAxNzkyNSw4LjIyMi4yMDguMTQ2&st=MTczMzAxNzkyNCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Comparison_and_correlation_of_VIA_and_Pa.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/113575503/2-7-47-181-libre.pdf?1713680396=\u0026response-content-disposition=attachment%3B+filename%3DComparison_and_correlation_of_VIA_and_Pa.pdf\u0026Expires=1733021524\u0026Signature=Dx8OYkkp67flkqhFGtY9jDIYlrEPctuQF6g1MqHOmC4zIi3Vog04w6S2yPDfHp6FqE6cyj3CG99I2OOT2mXNHhwODTY1jRhgpjTCOmaLuCPwgQltSbu5iLIvkKSjG9MkyjRzSSm89r~tUWTtPMF7f2GbwjLYQ7m~jQTBTyQAvZrfiMXyBtROlvIxQtXE033clh29PEbGT6M1DzT4yE1RyfM5vQj~B3z5wRE6tJ8BnB7O9xOfmLZM-LoCseBfP~CtSSpDbTj8FncbHtpblRAB61tLWZzxw4vn9VNG8dKflFP9k~mJKPuZ-PeAys9lT-W5nivrdfRKZs5AQ0XwH55liQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":81504,"name":"Correlation","url":"https://www.academia.edu/Documents/in/Correlation"},{"id":96502,"name":"Applied","url":"https://www.academia.edu/Documents/in/Applied"},{"id":203512,"name":"Cervical Cancer","url":"https://www.academia.edu/Documents/in/Cervical_Cancer"}],"urls":[{"id":41261868,"url":"https://www.allresearchjournal.com/archives/2016/vol2issue7/PartL/2-7-47-181.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="117807285"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/117807285/Region_specific_changes_in_the_mRNA_and_protein_expression_of_LCPUFA_biosynthesis_enzymes_and_transporters_in_the_placentae_of_women_with_preeclampsia"><img alt="Research paper thumbnail of Region-specific changes in the mRNA and protein expression of LCPUFA biosynthesis enzymes and transporters in the placentae of women with preeclampsia" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/117807285/Region_specific_changes_in_the_mRNA_and_protein_expression_of_LCPUFA_biosynthesis_enzymes_and_transporters_in_the_placentae_of_women_with_preeclampsia">Region-specific changes in the mRNA and protein expression of LCPUFA biosynthesis enzymes and transporters in the placentae of women with preeclampsia</a></div><div class="wp-workCard_item"><span>Placenta</span><span>, Jun 1, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The biosynthesis and transport of long chain polyunsaturated fatty acids (LCPUFA) require the act...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The biosynthesis and transport of long chain polyunsaturated fatty acids (LCPUFA) require the activity of fatty acid desaturase (FADS) enzymes, fatty acid transport proteins (FATP) and fatty acid binding proteins (FABP). In a previous study we have demonstrated region-specific changes in the LCPUFA levels in preeclampsia (PE) as compared to the normotensive control (NC) placentae. AIM To understand the region-specific changes in the mRNA levels and protein expression of biosynthesis enzymes and transporters of LCPUFA in PE and NC placentae. METHODS In this cross-sectional study, 20 NC women and 44 women with PE (23 term (TPE) and 21 preterm PE (PTPE)) were recruited. The samples were collected from four regions of the placentae considering cord insertion as the center (CM, central maternal/basal; CF, central fetal/chorionic; PM, peripheral maternal/basal and PF, peripheral fetal/chorionic). The mRNA levels were estimated using qRT-PCR. Statistical analysis was done using both post hoc least significant difference (LSD) test and Benjamini Hochberg correction in the analysis of covariance. Preliminarily, localization and expression of proteins were studied by immunohistochemistry (n = 3/group). RESULTS The mRNA levels of FADS1, FADS2 and FATP1 were lower in the central regions (CM and CF) of the PE placentae (both TPE and PTPE) as compared to NC. These differences in the mRNA levels were observed by the LSD test and were not significant after the Benjamini Hochberg correction. Preliminary findings of IHC indicate that the protein expression of FADS1 and FATP4 was higher in the basal regions (CM and PM) of the PE placentae as compared to NC. FADS1, FADS2 and FATP4 proteins were localized in the syncytiotrophoblasts, cytotrophoblasts, mesenchymal cells, endothelial cells of the fetal capillaries and extravillous trophoblasts of the placenta. CONCLUSION FADS enzymes are detected in the placentae of Indian women. In PE placentae, there are region-specific alterations in the mRNA and protein levels of LCPUFA biosynthesis enzymes (FADS1 and FADS2) and transporters (FATP1, FATP4 and FABP3) as compared to term NC. These changes were more pronounced toward the basal side and region around the cord insertion.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117807285"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117807285"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117807285; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=117807285]").text(description); $(".js-view-count[data-work-id=117807285]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 117807285; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='117807285']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 117807285, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=117807285]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":117807285,"title":"Region-specific changes in the mRNA and protein expression of LCPUFA biosynthesis enzymes and transporters in the placentae of women with preeclampsia","translated_title":"","metadata":{"abstract":"The biosynthesis and transport of long chain polyunsaturated fatty acids (LCPUFA) require the activity of fatty acid desaturase (FADS) enzymes, fatty acid transport proteins (FATP) and fatty acid binding proteins (FABP). In a previous study we have demonstrated region-specific changes in the LCPUFA levels in preeclampsia (PE) as compared to the normotensive control (NC) placentae. AIM To understand the region-specific changes in the mRNA levels and protein expression of biosynthesis enzymes and transporters of LCPUFA in PE and NC placentae. METHODS In this cross-sectional study, 20 NC women and 44 women with PE (23 term (TPE) and 21 preterm PE (PTPE)) were recruited. The samples were collected from four regions of the placentae considering cord insertion as the center (CM, central maternal/basal; CF, central fetal/chorionic; PM, peripheral maternal/basal and PF, peripheral fetal/chorionic). The mRNA levels were estimated using qRT-PCR. Statistical analysis was done using both post hoc least significant difference (LSD) test and Benjamini Hochberg correction in the analysis of covariance. Preliminarily, localization and expression of proteins were studied by immunohistochemistry (n = 3/group). RESULTS The mRNA levels of FADS1, FADS2 and FATP1 were lower in the central regions (CM and CF) of the PE placentae (both TPE and PTPE) as compared to NC. These differences in the mRNA levels were observed by the LSD test and were not significant after the Benjamini Hochberg correction. Preliminary findings of IHC indicate that the protein expression of FADS1 and FATP4 was higher in the basal regions (CM and PM) of the PE placentae as compared to NC. FADS1, FADS2 and FATP4 proteins were localized in the syncytiotrophoblasts, cytotrophoblasts, mesenchymal cells, endothelial cells of the fetal capillaries and extravillous trophoblasts of the placenta. CONCLUSION FADS enzymes are detected in the placentae of Indian women. In PE placentae, there are region-specific alterations in the mRNA and protein levels of LCPUFA biosynthesis enzymes (FADS1 and FADS2) and transporters (FATP1, FATP4 and FABP3) as compared to term NC. These changes were more pronounced toward the basal side and region around the cord insertion.","publisher":"Elsevier BV","publication_date":{"day":1,"month":6,"year":2020,"errors":{}},"publication_name":"Placenta"},"translated_abstract":"The biosynthesis and transport of long chain polyunsaturated fatty acids (LCPUFA) require the activity of fatty acid desaturase (FADS) enzymes, fatty acid transport proteins (FATP) and fatty acid binding proteins (FABP). In a previous study we have demonstrated region-specific changes in the LCPUFA levels in preeclampsia (PE) as compared to the normotensive control (NC) placentae. AIM To understand the region-specific changes in the mRNA levels and protein expression of biosynthesis enzymes and transporters of LCPUFA in PE and NC placentae. METHODS In this cross-sectional study, 20 NC women and 44 women with PE (23 term (TPE) and 21 preterm PE (PTPE)) were recruited. The samples were collected from four regions of the placentae considering cord insertion as the center (CM, central maternal/basal; CF, central fetal/chorionic; PM, peripheral maternal/basal and PF, peripheral fetal/chorionic). The mRNA levels were estimated using qRT-PCR. Statistical analysis was done using both post hoc least significant difference (LSD) test and Benjamini Hochberg correction in the analysis of covariance. Preliminarily, localization and expression of proteins were studied by immunohistochemistry (n = 3/group). RESULTS The mRNA levels of FADS1, FADS2 and FATP1 were lower in the central regions (CM and CF) of the PE placentae (both TPE and PTPE) as compared to NC. These differences in the mRNA levels were observed by the LSD test and were not significant after the Benjamini Hochberg correction. Preliminary findings of IHC indicate that the protein expression of FADS1 and FATP4 was higher in the basal regions (CM and PM) of the PE placentae as compared to NC. FADS1, FADS2 and FATP4 proteins were localized in the syncytiotrophoblasts, cytotrophoblasts, mesenchymal cells, endothelial cells of the fetal capillaries and extravillous trophoblasts of the placenta. CONCLUSION FADS enzymes are detected in the placentae of Indian women. In PE placentae, there are region-specific alterations in the mRNA and protein levels of LCPUFA biosynthesis enzymes (FADS1 and FADS2) and transporters (FATP1, FATP4 and FABP3) as compared to term NC. These changes were more pronounced toward the basal side and region around the cord insertion.","internal_url":"https://www.academia.edu/117807285/Region_specific_changes_in_the_mRNA_and_protein_expression_of_LCPUFA_biosynthesis_enzymes_and_transporters_in_the_placentae_of_women_with_preeclampsia","translated_internal_url":"","created_at":"2024-04-20T22:14:10.316-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":69187415,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Region_specific_changes_in_the_mRNA_and_protein_expression_of_LCPUFA_biosynthesis_enzymes_and_transporters_in_the_placentae_of_women_with_preeclampsia","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":69187415,"first_name":"Girija","middle_initials":null,"last_name":"Wagh","page_name":"GirijaWagh","domain_name":"independent","created_at":"2017-10-08T07:35:52.661-07:00","display_name":"Girija Wagh","url":"https://independent.academia.edu/GirijaWagh"},"attachments":[],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":76061,"name":"Placenta","url":"https://www.academia.edu/Documents/in/Placenta"},{"id":86745,"name":"Preeclampsia","url":"https://www.academia.edu/Documents/in/Preeclampsia"},{"id":231661,"name":"Enzyme","url":"https://www.academia.edu/Documents/in/Enzyme"},{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"},{"id":433495,"name":"Biosynthesis","url":"https://www.academia.edu/Documents/in/Biosynthesis"},{"id":568122,"name":"Transporter","url":"https://www.academia.edu/Documents/in/Transporter"},{"id":3789883,"name":"Paediatrics and reproductive medicine","url":"https://www.academia.edu/Documents/in/Paediatrics_and_reproductive_medicine"}],"urls":[{"id":41261867,"url":"https://doi.org/10.1016/j.placenta.2020.04.013"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="117807284"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/117807284/Early_Pregnancy_Hemorrhage"><img alt="Research paper thumbnail of Early Pregnancy Hemorrhage" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/117807284/Early_Pregnancy_Hemorrhage">Early Pregnancy Hemorrhage</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117807284"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117807284"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117807284; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=117807284]").text(description); $(".js-view-count[data-work-id=117807284]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 117807284; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='117807284']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 117807284, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=117807284]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":117807284,"title":"Early Pregnancy Hemorrhage","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2018,"errors":{}}},"translated_abstract":null,"internal_url":"https://www.academia.edu/117807284/Early_Pregnancy_Hemorrhage","translated_internal_url":"","created_at":"2024-04-20T22:14:09.992-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":69187415,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Early_Pregnancy_Hemorrhage","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":69187415,"first_name":"Girija","middle_initials":null,"last_name":"Wagh","page_name":"GirijaWagh","domain_name":"independent","created_at":"2017-10-08T07:35:52.661-07:00","display_name":"Girija Wagh","url":"https://independent.academia.edu/GirijaWagh","email":"MkNVdzhxNFQ5aUZTRjRRZTlQNGR1Q1lWcDgvSFo2Y1RtaTc3bE5uRTQ5RT0tLWtVdUMwUkFkMHNyLzNKVkszYWY1cVE9PQ==--a35574ea5e65e3565ec17f5f4cf38be6b92dd466"},"attachments":[],"research_interests":[{"id":625,"name":"Obstetrics","url":"https://www.academia.edu/Documents/in/Obstetrics"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy"}],"urls":[{"id":41261866,"url":"https://doi.org/10.5005/jp/books/14143_16"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="117807282"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/117807282/Placental_DHA_and_mRNA_levels_of_PPAR%CE%B3_and_LXR%CE%B1_and_their_relationship_to_birth_weight"><img alt="Research paper thumbnail of Placental DHA and mRNA levels of PPARγ and LXRα and their relationship to birth weight" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/117807282/Placental_DHA_and_mRNA_levels_of_PPAR%CE%B3_and_LXR%CE%B1_and_their_relationship_to_birth_weight">Placental DHA and mRNA levels of PPARγ and LXRα and their relationship to birth weight</a></div><div class="wp-workCard_item"><span>Journal of Clinical Lipidology</span><span>, Jul 1, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">A very large number of fatty acids play wide range of physiological roles in cellular growth and ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">A very large number of fatty acids play wide range of physiological roles in cellular growth and function in placental as well as fetal growth. However, docosahexaenoic acid (DHA), in addition to its critical role in cellular membranes, is known to act as a ligand for several nuclear receptors and regulates the activity of transcription factor families like peroxisome proliferator-activated receptor, liver X receptor (LXR), retinoid X receptor (RXR), and sterol regulatory element binding protein (SREBP). These transcription factors and DHA are known to regulate the placental and fetal growth and development. The objective of the present study was to examine the fatty acids and transcription factors in the placenta of women delivering low birth weight (LBW) babies. The present study examines the fatty acid and mRNA levels of various transcription factors in the placentae of women delivering normal birth weight (NBW) (n = 38) and women delivering LBW (n = 36). Placental fatty acids were analyzed using gas chromatography. Placental mRNA levels of PPARα, PPARγ, SREBP-1c, LXRα, RXRα, and RXRγ were examined using quantitative real time PCR. Placental DHA levels and mRNA levels of placental PPARγ and LXRα were lower (P &amp;amp;amp;lt; .05 for all) in women delivering LBW babies. There was a positive association of placental PPARγ mRNA levels and placental DHA levels with baby weight (P &amp;amp;amp;lt; .05 for both). Our data suggest that lower placental DHA and transcription factors may have a vital role in the etiology of LBW babies.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="117807282"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="117807282"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 117807282; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=117807282]").text(description); $(".js-view-count[data-work-id=117807282]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 117807282; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='117807282']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 117807282, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=117807282]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":117807282,"title":"Placental DHA and mRNA levels of PPARγ and LXRα and their relationship to birth weight","translated_title":"","metadata":{"abstract":"A very large number of fatty acids play wide range of physiological roles in cellular growth and function in placental as well as fetal growth. However, docosahexaenoic acid (DHA), in addition to its critical role in cellular membranes, is known to act as a ligand for several nuclear receptors and regulates the activity of transcription factor families like peroxisome proliferator-activated receptor, liver X receptor (LXR), retinoid X receptor (RXR), and sterol regulatory element binding protein (SREBP). These transcription factors and DHA are known to regulate the placental and fetal growth and development. The objective of the present study was to examine the fatty acids and transcription factors in the placenta of women delivering low birth weight (LBW) babies. The present study examines the fatty acid and mRNA levels of various transcription factors in the placentae of women delivering normal birth weight (NBW) (n = 38) and women delivering LBW (n = 36). Placental fatty acids were analyzed using gas chromatography. Placental mRNA levels of PPARα, PPARγ, SREBP-1c, LXRα, RXRα, and RXRγ were examined using quantitative real time PCR. Placental DHA levels and mRNA levels of placental PPARγ and LXRα were lower (P \u0026amp;amp;amp;lt; .05 for all) in women delivering LBW babies. There was a positive association of placental PPARγ mRNA levels and placental DHA levels with baby weight (P \u0026amp;amp;amp;lt; .05 for both). Our data suggest that lower placental DHA and transcription factors may have a vital role in the etiology of LBW babies.","publisher":"Elsevier BV","publication_date":{"day":1,"month":7,"year":2016,"errors":{}},"publication_name":"Journal of Clinical Lipidology"},"translated_abstract":"A very large number of fatty acids play wide range of physiological roles in cellular growth and function in placental as well as fetal growth. 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Placental mRNA levels of PPARα, PPARγ, SREBP-1c, LXRα, RXRα, and RXRγ were examined using quantitative real time PCR. Placental DHA levels and mRNA levels of placental PPARγ and LXRα were lower (P \u0026amp;amp;amp;lt; .05 for all) in women delivering LBW babies. There was a positive association of placental PPARγ mRNA levels and placental DHA levels with baby weight (P \u0026amp;amp;amp;lt; .05 for both). Our data suggest that lower placental DHA and transcription factors may have a vital role in the etiology of LBW babies.","internal_url":"https://www.academia.edu/117807282/Placental_DHA_and_mRNA_levels_of_PPAR%CE%B3_and_LXR%CE%B1_and_their_relationship_to_birth_weight","translated_internal_url":"","created_at":"2024-04-20T22:14:09.610-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":69187415,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Placental_DHA_and_mRNA_levels_of_PPARγ_and_LXRα_and_their_relationship_to_birth_weight","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":69187415,"first_name":"Girija","middle_initials":null,"last_name":"Wagh","page_name":"GirijaWagh","domain_name":"independent","created_at":"2017-10-08T07:35:52.661-07:00","display_name":"Girija Wagh","url":"https://independent.academia.edu/GirijaWagh"},"attachments":[],"research_interests":[{"id":154,"name":"Endocrinology","url":"https://www.academia.edu/Documents/in/Endocrinology"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":23323,"name":"Transcription Factors","url":"https://www.academia.edu/Documents/in/Transcription_Factors"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":47155,"name":"Birth Weight","url":"https://www.academia.edu/Documents/in/Birth_Weight"},{"id":62550,"name":"Pregnancy","url":"https://www.academia.edu/Documents/in/Pregnancy"},{"id":65390,"name":"Internal Medicine","url":"https://www.academia.edu/Documents/in/Internal_Medicine"},{"id":76061,"name":"Placenta","url":"https://www.academia.edu/Documents/in/Placenta"},{"id":133057,"name":"Young Adult","url":"https://www.academia.edu/Documents/in/Young_Adult"},{"id":170483,"name":"Peroxisome proliferator-activated receptor","url":"https://www.academia.edu/Documents/in/Peroxisome_proliferator-activated_receptor"},{"id":253560,"name":"Newborn Infant","url":"https://www.academia.edu/Documents/in/Newborn_Infant"},{"id":770944,"name":"Fetus","url":"https://www.academia.edu/Documents/in/Fetus"},{"id":1611350,"name":"Docosahexaenoic Acid","url":"https://www.academia.edu/Documents/in/Docosahexaenoic_Acid"},{"id":1643369,"name":"retinoid X receptor","url":"https://www.academia.edu/Documents/in/retinoid_X_receptor"},{"id":3789879,"name":"Cardiovascular medicine and haematology","url":"https://www.academia.edu/Documents/in/Cardiovascular_medicine_and_haematology"},{"id":3789880,"name":"Medical biochemistry and metabolomics","url":"https://www.academia.edu/Documents/in/Medical_biochemistry_and_metabolomics"}],"urls":[{"id":41261864,"url":"https://doi.org/10.1016/j.jacl.2016.02.004"}]}, dispatcherData: dispatcherData }); 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