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Seetharamappa<br /><b>Address: </b>Research Scolar,<br />Dept of Chemistry.<br />Karnatak University,<br />Dharwad-580 003. Karnataka, INDIA<br /><div class="js-profile-less-about u-linkUnstyled u-tcGrayDarker u-textDecorationUnderline u-displayNone">less</div></div></div><div class="suggested-academics-container"><div class="suggested-academics--header"><p class="ds2-5-body-md-bold">Related Authors</p></div><ul class="suggested-user-card-list"><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://tufts.academia.edu/AyseAsatekin"><img class="profile-avatar u-positionAbsolute" alt="Ayse Asatekin" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/9022/3138/3111/s200_ayse.asatekin.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://tufts.academia.edu/AyseAsatekin">Ayse 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Madkour</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Al-Baha University, Kingdom of Saudi Arabia</p></div></div><div class="suggested-user-card"><div class="suggested-user-card__avatar social-profile-avatar-container"><a href="https://neu.academia.edu/ConstantinosZeinalipourYazdi"><img class="profile-avatar u-positionAbsolute" alt="Constantinos D Zeinalipour-Yazdi" border="0" onerror="if (this.src != '//a.academia-assets.com/images/s200_no_pic.png') this.src = '//a.academia-assets.com/images/s200_no_pic.png';" width="200" height="200" src="https://0.academia-photos.com/3306498/1101653/162732575/s200_constantinos.zeinalipour-yazdi.jpg" /></a></div><div class="suggested-user-card__user-info"><a class="suggested-user-card__user-info__header ds2-5-body-sm-bold ds2-5-body-link" href="https://neu.academia.edu/ConstantinosZeinalipourYazdi">Constantinos D Zeinalipour-Yazdi</a><p class="suggested-user-card__user-info__subheader ds2-5-body-xs">Northeastern 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data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/UmeshaKatrahalli","location":"/UmeshaKatrahalli","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/UmeshaKatrahalli","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Chemistry"]}" data-trace="false" data-dom-id="Pill-react-component-78e40d65-8323-4d2f-aa7b-f6a277aac8c8"></div> <div id="Pill-react-component-78e40d65-8323-4d2f-aa7b-f6a277aac8c8"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Umesha Katrahalli</h3></div><div class="js-work-strip profile--work_container" data-work-id="96076174"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/96076174/Insights_from_Spectroscopic_Methods"><img alt="Research paper thumbnail of Insights from Spectroscopic Methods" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/96076174/Insights_from_Spectroscopic_Methods">Insights from Spectroscopic Methods</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This is an Open Access article distributed under the terms of the Creative Commons Attribution Li...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This is an Open Access article distributed under the terms of the Creative Commons Attribution License</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" 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src="https://attachments.academia-assets.com/98075455/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96076173/Electrochemical_Behavior_of_Xanthene_Food_Dye_Erythrosine_at_Glassy_Carbon_Electrode_and_Its_Analytical_Applications">Electrochemical Behavior of Xanthene Food Dye Erythrosine at Glassy Carbon Electrode and Its Analytical Applications</a></div><div class="wp-workCard_item"><span>Asian Journal of Pharmaceutical and Clinical Research</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Erythrosine is a xanthene food dye used in the food industries to enhance the appearance of the f...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Erythrosine is a xanthene food dye used in the food industries to enhance the appearance of the food. The electrochemical behavior of erythrosine at glassy carbon electrode was investigated by cyclic and differential pulse voltammetry. The oxidation peak of erythrosine was observed in phosphate buffer of pH 5.0. The influence of different pH, scan rate and concentration were evaluated. The probable reaction mechanism involved in the oxidation of erythrosine was also proposed. Differential pulse voltammetric method with good precision and accuracy was developed for the determination of erythrosine dye in real samples. The peak currents were found to be linearly dependent on the concentration range of 1 x 10 -5 to 6 x 10 -4 M. The limit of detection (LOD) and limit of quantification (LOQ) were noticed to be 1.9 x 10 -7 and 6.6 x 10 -7 M respectively.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f6ec98119a9c5b9e4d8f4b358a312675" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98075455,"asset_id":96076173,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98075455/download_file?st=MTczNzI1ODQyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96076173"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96076173"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96076173; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96076173]").text(description); $(".js-view-count[data-work-id=96076173]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96076173; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96076173']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96076173, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f6ec98119a9c5b9e4d8f4b358a312675" } } $('.js-work-strip[data-work-id=96076173]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96076173,"title":"Electrochemical Behavior of Xanthene Food Dye Erythrosine at Glassy Carbon Electrode and Its Analytical Applications","translated_title":"","metadata":{"abstract":"Erythrosine is a xanthene food dye used in the food industries to enhance the appearance of the food. The electrochemical behavior of erythrosine at glassy carbon electrode was investigated by cyclic and differential pulse voltammetry. The oxidation peak of erythrosine was observed in phosphate buffer of pH 5.0. The influence of different pH, scan rate and concentration were evaluated. The probable reaction mechanism involved in the oxidation of erythrosine was also proposed. Differential pulse voltammetric method with good precision and accuracy was developed for the determination of erythrosine dye in real samples. The peak currents were found to be linearly dependent on the concentration range of 1 x 10 -5 to 6 x 10 -4 M. The limit of detection (LOD) and limit of quantification (LOQ) were noticed to be 1.9 x 10 -7 and 6.6 x 10 -7 M respectively.","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Asian Journal of Pharmaceutical and Clinical Research"},"translated_abstract":"Erythrosine is a xanthene food dye used in the food industries to enhance the appearance of the food. The electrochemical behavior of erythrosine at glassy carbon electrode was investigated by cyclic and differential pulse voltammetry. The oxidation peak of erythrosine was observed in phosphate buffer of pH 5.0. The influence of different pH, scan rate and concentration were evaluated. The probable reaction mechanism involved in the oxidation of erythrosine was also proposed. Differential pulse voltammetric method with good precision and accuracy was developed for the determination of erythrosine dye in real samples. The peak currents were found to be linearly dependent on the concentration range of 1 x 10 -5 to 6 x 10 -4 M. The limit of detection (LOD) and limit of quantification (LOQ) were noticed to be 1.9 x 10 -7 and 6.6 x 10 -7 M respectively.","internal_url":"https://www.academia.edu/96076173/Electrochemical_Behavior_of_Xanthene_Food_Dye_Erythrosine_at_Glassy_Carbon_Electrode_and_Its_Analytical_Applications","translated_internal_url":"","created_at":"2023-01-31T19:48:35.586-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":327642,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":98075455,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/98075455/thumbnails/1.jpg","file_name":"2701.pdf","download_url":"https://www.academia.edu/attachments/98075455/download_file?st=MTczNzI1ODQyOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Electrochemical_Behavior_of_Xanthene_Foo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/98075455/2701-libre.pdf?1675223725=\u0026response-content-disposition=attachment%3B+filename%3DElectrochemical_Behavior_of_Xanthene_Foo.pdf\u0026Expires=1737262028\u0026Signature=bSYioWvTt-8hCahSGtuxQP5CbZMp9XnkvUF00JuwnGIbIE20gtm-wF9-qlPxhff0bKBwauE4CkKJ~EcU41Yj0W3kcHxsdc9YSgffsFv-KuU2ln6OqYnpWqlCt9ieznSuiKLekRTnLd-18VI~lXwF-lYb0FnuXTayXZ9a~jlsgcxb3PExKbAxZfZ3Ly9qf9qHUxzfpi6ktOFTtvoECLlR3gN68n2oxpx7hDxeeK3Evx2Jb6U6TRVxO2OfVLOrX5D-JK9ZTmadoJLd55n6aKsLOkr-QfFfSBCOcX9APkS7o8Z5ophSSfygRAfjjY599ve~CH5XpR~N4vI73NlRzaXpkw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Electrochemical_Behavior_of_Xanthene_Food_Dye_Erythrosine_at_Glassy_Carbon_Electrode_and_Its_Analytical_Applications","translated_slug":"","page_count":5,"language":"en","content_type":"Work","summary":"Erythrosine is a xanthene food dye used in the food industries to enhance the appearance of the food. The electrochemical behavior of erythrosine at glassy carbon electrode was investigated by cyclic and differential pulse voltammetry. The oxidation peak of erythrosine was observed in phosphate buffer of pH 5.0. The influence of different pH, scan rate and concentration were evaluated. The probable reaction mechanism involved in the oxidation of erythrosine was also proposed. Differential pulse voltammetric method with good precision and accuracy was developed for the determination of erythrosine dye in real samples. The peak currents were found to be linearly dependent on the concentration range of 1 x 10 -5 to 6 x 10 -4 M. The limit of detection (LOD) and limit of quantification (LOQ) were noticed to be 1.9 x 10 -7 and 6.6 x 10 -7 M respectively.","owner":{"id":327642,"first_name":"Umesha","middle_initials":null,"last_name":"Katrahalli","page_name":"UmeshaKatrahalli","domain_name":"independent","created_at":"2011-02-09T18:09:32.699-08:00","display_name":"Umesha Katrahalli","url":"https://independent.academia.edu/UmeshaKatrahalli"},"attachments":[{"id":98075455,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/98075455/thumbnails/1.jpg","file_name":"2701.pdf","download_url":"https://www.academia.edu/attachments/98075455/download_file?st=MTczNzI1ODQyOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Electrochemical_Behavior_of_Xanthene_Foo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/98075455/2701-libre.pdf?1675223725=\u0026response-content-disposition=attachment%3B+filename%3DElectrochemical_Behavior_of_Xanthene_Foo.pdf\u0026Expires=1737262028\u0026Signature=bSYioWvTt-8hCahSGtuxQP5CbZMp9XnkvUF00JuwnGIbIE20gtm-wF9-qlPxhff0bKBwauE4CkKJ~EcU41Yj0W3kcHxsdc9YSgffsFv-KuU2ln6OqYnpWqlCt9ieznSuiKLekRTnLd-18VI~lXwF-lYb0FnuXTayXZ9a~jlsgcxb3PExKbAxZfZ3Ly9qf9qHUxzfpi6ktOFTtvoECLlR3gN68n2oxpx7hDxeeK3Evx2Jb6U6TRVxO2OfVLOrX5D-JK9ZTmadoJLd55n6aKsLOkr-QfFfSBCOcX9APkS7o8Z5ophSSfygRAfjjY599ve~CH5XpR~N4vI73NlRzaXpkw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":4748,"name":"Electrochemistry","url":"https://www.academia.edu/Documents/in/Electrochemistry"},{"id":20902,"name":"Cyclic Voltammetry","url":"https://www.academia.edu/Documents/in/Cyclic_Voltammetry"},{"id":906971,"name":"Electrochemical Studies","url":"https://www.academia.edu/Documents/in/Electrochemical_Studies"},{"id":1608498,"name":"Differential Pulse Voltammetry","url":"https://www.academia.edu/Documents/in/Differential_Pulse_Voltammetry"},{"id":1765959,"name":"Pharmaceutical Formulation","url":"https://www.academia.edu/Documents/in/Pharmaceutical_Formulation"},{"id":2868294,"name":"Erythrosine B","url":"https://www.academia.edu/Documents/in/Erythrosine_B"}],"urls":[]}, dispatcherData: dispatcherData }); 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FLX was found to quench the intrinsic fluorescence of protein by static ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="52593179"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="52593179"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 52593179; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=52593179]").text(description); $(".js-view-count[data-work-id=52593179]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 52593179; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='52593179']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 52593179, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=52593179]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":52593179,"title":"Study of the interaction between fluoxetine hydrochloride and bovine serum albumin in the imitated physiological conditions by multi-spectroscopic methods","translated_title":"","metadata":{"abstract":"The mechanism of interaction of an antidepressant, fluoxetine hydrochloride (FLX) with bovine serum albumin (BSA) has been studied by different spectroscopic techniques under physiological conditions. 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FLX was found to quench the intrinsic fluorescence of protein by static ...","owner":{"id":327642,"first_name":"Umesha","middle_initials":null,"last_name":"Katrahalli","page_name":"UmeshaKatrahalli","domain_name":"independent","created_at":"2011-02-09T18:09:32.699-08:00","display_name":"Umesha Katrahalli","url":"https://independent.academia.edu/UmeshaKatrahalli"},"attachments":[],"research_interests":[{"id":5427,"name":"Spectroscopy","url":"https://www.academia.edu/Documents/in/Spectroscopy"},{"id":76408,"name":"Albumin","url":"https://www.academia.edu/Documents/in/Albumin"},{"id":158914,"name":"Luminescence","url":"https://www.academia.edu/Documents/in/Luminescence"},{"id":263152,"name":"Optical physics","url":"https://www.academia.edu/Documents/in/Optical_physics"},{"id":416713,"name":"Spectrometry","url":"https://www.academia.edu/Documents/in/Spectrometry"},{"id":881608,"name":"Bovine Serum Albumin","url":"https://www.academia.edu/Documents/in/Bovine_Serum_Albumin"},{"id":1242506,"name":"Binding Site","url":"https://www.academia.edu/Documents/in/Binding_Site"}],"urls":[{"id":11254611,"url":"http://adsabs.harvard.edu/abs/2010jlum..130..211k"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="52593178"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/52593178/Voltammetric_and_spectroscopic_investigations_on_the_mechanism_of_interaction_of_buzepide_methiodide_with_protein"><img alt="Research paper thumbnail of Voltammetric and spectroscopic investigations on the mechanism of interaction of buzepide methiodide with protein" class="work-thumbnail" src="https://attachments.academia-assets.com/69785192/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/52593178/Voltammetric_and_spectroscopic_investigations_on_the_mechanism_of_interaction_of_buzepide_methiodide_with_protein">Voltammetric and spectroscopic investigations on the mechanism of interaction of buzepide methiodide with protein</a></div><div class="wp-workCard_item"><span>Colloids and Surfaces B Biointerfaces</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Adsorption or immobilization of proteins on solid surfaces promotes the biological responses to m...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Adsorption or immobilization of proteins on solid surfaces promotes the biological responses to materials. Using immobilization technique, we have prepared human serum albumin (HSA) modified glassy carbon electrode (GCE) and employed it to probe the mode of interaction between antidepressant drug, buzepide methiodide (BZP) and HSA. At HSA modified GCE, the peak potential of BZP appeared at more positive potential compared to that at bare electrode thereby indicating the hydrophobic mode of interaction between BZP and HSA. Peak currents of BZP decreased upon the addition of HSA at bare GCE with positive shift in peak potential. Further, no new peaks were observed in presence of HSA. From electrochemical data, the binding constant and binding ratio between HSA and BZP were calculated to be 9.33 × 10 6 M −1 and 1:2, respectively. FT-IR and circular dichroism (CD) studies revealed that the secondary structure of protein was perturbed upon interaction with BZP.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6979eb0257b54818d586e266d936939c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":69785192,"asset_id":52593178,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/69785192/download_file?st=MTczNzI1ODQyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="52593178"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="52593178"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 52593178; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=52593178]").text(description); $(".js-view-count[data-work-id=52593178]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 52593178; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='52593178']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 52593178, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6979eb0257b54818d586e266d936939c" } } $('.js-work-strip[data-work-id=52593178]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":52593178,"title":"Voltammetric and spectroscopic investigations on the mechanism of interaction of buzepide methiodide with protein","translated_title":"","metadata":{"grobid_abstract":"Adsorption or immobilization of proteins on solid surfaces promotes the biological responses to materials. 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FT-IR and circular dichroism (CD) studies revealed that the secondary structure of protein was perturbed upon interaction with BZP.","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Colloids and Surfaces B Biointerfaces","grobid_abstract_attachment_id":69785192},"translated_abstract":null,"internal_url":"https://www.academia.edu/52593178/Voltammetric_and_spectroscopic_investigations_on_the_mechanism_of_interaction_of_buzepide_methiodide_with_protein","translated_internal_url":"","created_at":"2021-09-16T23:31:09.218-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":327642,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":69785192,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/69785192/thumbnails/1.jpg","file_name":"j.colsurfb.2009.08.01120210916-6241-1iqddpu.pdf","download_url":"https://www.academia.edu/attachments/69785192/download_file?st=MTczNzI1ODQyOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Voltammetric_and_spectroscopic_investiga.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/69785192/j.colsurfb.2009.08.01120210916-6241-1iqddpu-libre.pdf?1631861300=\u0026response-content-disposition=attachment%3B+filename%3DVoltammetric_and_spectroscopic_investiga.pdf\u0026Expires=1737262028\u0026Signature=Tl6PolcLyCbS86OKvJ6kqaI6EBBo6a1VJG1NHdi3ipFyvkpLvX2nI4k7uyEFbTJsPVzK-JrhA~3wqQ-UjOyeStmmLF0WfmelRbJB4cXtsWbcDu65d0pzq-1E6dkJCR8Z3rt6hOYpeqZP0xZvlfTHizmB6drIVdf42lGGHLAwr3ulOySr-BAgeDgJo40bcU2jfK1A8hrihVYRr3nYTZ-OzBIAQaPuw1XkJ4eWl8zJkavIcpg9Jj1eqN99ADsv8kNunjta8ODJ~TMIEIK6Ap11s84bD2uC41rghvB55gIp5o9IjSM0xbaGl9XimXFBcSPdT1Ty8~NoPENdKhWsV2B~0Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Voltammetric_and_spectroscopic_investigations_on_the_mechanism_of_interaction_of_buzepide_methiodide_with_protein","translated_slug":"","page_count":5,"language":"en","content_type":"Work","summary":"Adsorption or immobilization of proteins on solid surfaces promotes the biological responses to materials. Using immobilization technique, we have prepared human serum albumin (HSA) modified glassy carbon electrode (GCE) and employed it to probe the mode of interaction between antidepressant drug, buzepide methiodide (BZP) and HSA. At HSA modified GCE, the peak potential of BZP appeared at more positive potential compared to that at bare electrode thereby indicating the hydrophobic mode of interaction between BZP and HSA. Peak currents of BZP decreased upon the addition of HSA at bare GCE with positive shift in peak potential. Further, no new peaks were observed in presence of HSA. From electrochemical data, the binding constant and binding ratio between HSA and BZP were calculated to be 9.33 × 10 6 M −1 and 1:2, respectively. FT-IR and circular dichroism (CD) studies revealed that the secondary structure of protein was perturbed upon interaction with BZP.","owner":{"id":327642,"first_name":"Umesha","middle_initials":null,"last_name":"Katrahalli","page_name":"UmeshaKatrahalli","domain_name":"independent","created_at":"2011-02-09T18:09:32.699-08:00","display_name":"Umesha Katrahalli","url":"https://independent.academia.edu/UmeshaKatrahalli"},"attachments":[{"id":69785192,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/69785192/thumbnails/1.jpg","file_name":"j.colsurfb.2009.08.01120210916-6241-1iqddpu.pdf","download_url":"https://www.academia.edu/attachments/69785192/download_file?st=MTczNzI1ODQyOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Voltammetric_and_spectroscopic_investiga.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/69785192/j.colsurfb.2009.08.01120210916-6241-1iqddpu-libre.pdf?1631861300=\u0026response-content-disposition=attachment%3B+filename%3DVoltammetric_and_spectroscopic_investiga.pdf\u0026Expires=1737262028\u0026Signature=Tl6PolcLyCbS86OKvJ6kqaI6EBBo6a1VJG1NHdi3ipFyvkpLvX2nI4k7uyEFbTJsPVzK-JrhA~3wqQ-UjOyeStmmLF0WfmelRbJB4cXtsWbcDu65d0pzq-1E6dkJCR8Z3rt6hOYpeqZP0xZvlfTHizmB6drIVdf42lGGHLAwr3ulOySr-BAgeDgJo40bcU2jfK1A8hrihVYRr3nYTZ-OzBIAQaPuw1XkJ4eWl8zJkavIcpg9Jj1eqN99ADsv8kNunjta8ODJ~TMIEIK6Ap11s84bD2uC41rghvB55gIp5o9IjSM0xbaGl9XimXFBcSPdT1Ty8~NoPENdKhWsV2B~0Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":72,"name":"Chemical Engineering","url":"https://www.academia.edu/Documents/in/Chemical_Engineering"},{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering"},{"id":5303,"name":"Carbon","url":"https://www.academia.edu/Documents/in/Carbon"},{"id":7742,"name":"Glass","url":"https://www.academia.edu/Documents/in/Glass"},{"id":76407,"name":"Circular Dichroism","url":"https://www.academia.edu/Documents/in/Circular_Dichroism"},{"id":337175,"name":"Secondary Structure","url":"https://www.academia.edu/Documents/in/Secondary_Structure"},{"id":398650,"name":"Fourier transform infrared spectroscopy","url":"https://www.academia.edu/Documents/in/Fourier_transform_infrared_spectroscopy"},{"id":414692,"name":"Solutions","url":"https://www.academia.edu/Documents/in/Solutions"},{"id":846015,"name":"Electrodes","url":"https://www.academia.edu/Documents/in/Electrodes"},{"id":2349258,"name":"Serum albumin","url":"https://www.academia.edu/Documents/in/Serum_albumin"},{"id":3686577,"name":"Human serum albumin","url":"https://www.academia.edu/Documents/in/Human_serum_albumin"}],"urls":[{"id":11254610,"url":"http://cat.inist.fr/?aModele=afficheN\u0026cpsidt=22273622"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="52593177"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/52593177/Mechanistic_and_conformational_studies_on_the_interaction_of_anti_inflammatory_drugs_isoxicam_and_tenoxicam_with_bovine_serum_albumin"><img alt="Research paper thumbnail of Mechanistic and conformational studies on the interaction of anti-inflammatory drugs, isoxicam and tenoxicam with bovine serum albumin" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/52593177/Mechanistic_and_conformational_studies_on_the_interaction_of_anti_inflammatory_drugs_isoxicam_and_tenoxicam_with_bovine_serum_albumin">Mechanistic and conformational studies on the interaction of anti-inflammatory drugs, isoxicam and tenoxicam with bovine serum albumin</a></div><div class="wp-workCard_item"><span>Journal of Luminescence</span><span>, Nov 1, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The mechanism of interaction of the non-steroidal anti-inflammatory drugs, isoxicam (IXM) and ten...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The mechanism of interaction of the non-steroidal anti-inflammatory drugs, isoxicam (IXM) and tenoxicam (TXM) with bovine serum albumin (BSA) has been studied using spectroscopic techniques viz., spectrofluorescence, circular dichroism (CD), UV-Visible absorption and FT-IR under ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="52593177"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="52593177"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 52593177; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=52593177]").text(description); $(".js-view-count[data-work-id=52593177]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 52593177; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='52593177']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 52593177, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=52593177]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":52593177,"title":"Mechanistic and conformational studies on the interaction of anti-inflammatory drugs, isoxicam and tenoxicam with bovine serum albumin","translated_title":"","metadata":{"abstract":"The mechanism of interaction of the non-steroidal anti-inflammatory drugs, isoxicam (IXM) and tenoxicam (TXM) with bovine serum albumin (BSA) has been studied using spectroscopic techniques viz., spectrofluorescence, circular dichroism (CD), UV-Visible absorption and FT-IR under ...","publication_date":{"day":1,"month":11,"year":2010,"errors":{}},"publication_name":"Journal of Luminescence"},"translated_abstract":"The mechanism of interaction of the non-steroidal anti-inflammatory drugs, isoxicam (IXM) and tenoxicam (TXM) with bovine serum albumin (BSA) has been studied using spectroscopic techniques viz., spectrofluorescence, circular dichroism (CD), UV-Visible absorption and FT-IR under ...","internal_url":"https://www.academia.edu/52593177/Mechanistic_and_conformational_studies_on_the_interaction_of_anti_inflammatory_drugs_isoxicam_and_tenoxicam_with_bovine_serum_albumin","translated_internal_url":"","created_at":"2021-09-16T23:31:09.101-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":327642,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Mechanistic_and_conformational_studies_on_the_interaction_of_anti_inflammatory_drugs_isoxicam_and_tenoxicam_with_bovine_serum_albumin","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"The mechanism of interaction of the non-steroidal anti-inflammatory drugs, isoxicam (IXM) and tenoxicam (TXM) with bovine serum albumin (BSA) has been studied using spectroscopic techniques viz., spectrofluorescence, circular dichroism (CD), UV-Visible absorption and FT-IR under ...","owner":{"id":327642,"first_name":"Umesha","middle_initials":null,"last_name":"Katrahalli","page_name":"UmeshaKatrahalli","domain_name":"independent","created_at":"2011-02-09T18:09:32.699-08:00","display_name":"Umesha Katrahalli","url":"https://independent.academia.edu/UmeshaKatrahalli"},"attachments":[],"research_interests":[{"id":3770,"name":"Metabolism","url":"https://www.academia.edu/Documents/in/Metabolism"},{"id":11111,"name":"Pharmacokinetics","url":"https://www.academia.edu/Documents/in/Pharmacokinetics"},{"id":75647,"name":"Interactions","url":"https://www.academia.edu/Documents/in/Interactions"},{"id":76407,"name":"Circular Dichroism","url":"https://www.academia.edu/Documents/in/Circular_Dichroism"},{"id":158914,"name":"Luminescence","url":"https://www.academia.edu/Documents/in/Luminescence"},{"id":263152,"name":"Optical physics","url":"https://www.academia.edu/Documents/in/Optical_physics"},{"id":717129,"name":"Energy Transfer","url":"https://www.academia.edu/Documents/in/Energy_Transfer"},{"id":881608,"name":"Bovine Serum Albumin","url":"https://www.academia.edu/Documents/in/Bovine_Serum_Albumin"},{"id":907359,"name":"Infrared Spectrometry","url":"https://www.academia.edu/Documents/in/Infrared_Spectrometry"},{"id":952991,"name":"Spectroscopic Techniques","url":"https://www.academia.edu/Documents/in/Spectroscopic_Techniques"},{"id":1274450,"name":"Conformational Change","url":"https://www.academia.edu/Documents/in/Conformational_Change"},{"id":1291063,"name":"Thermodynamic Parameter","url":"https://www.academia.edu/Documents/in/Thermodynamic_Parameter"},{"id":2349258,"name":"Serum albumin","url":"https://www.academia.edu/Documents/in/Serum_albumin"},{"id":2412368,"name":"Fluorescence quenching","url":"https://www.academia.edu/Documents/in/Fluorescence_quenching"}],"urls":[{"id":11254609,"url":"http://cat.inist.fr/?aModele=afficheN\u0026cpsidt=23213354"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="52593176"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/52593176/Synthesis_crystal_studies_and_in_vivo_anti_hyperlipidemic_activities_of_indole_derivatives_containing_fluvastatin_nucleus"><img alt="Research paper thumbnail of Synthesis, crystal studies and in vivo anti-hyperlipidemic activities of indole derivatives containing fluvastatin nucleus" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/52593176/Synthesis_crystal_studies_and_in_vivo_anti_hyperlipidemic_activities_of_indole_derivatives_containing_fluvastatin_nucleus">Synthesis, crystal studies and in vivo anti-hyperlipidemic activities of indole derivatives containing fluvastatin nucleus</a></div><div class="wp-workCard_item"><span>RSC Adv.</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">As a part of our efforts to prepare better analogues of fluvastatin for the treatment of hyperlip...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">As a part of our efforts to prepare better analogues of fluvastatin for the treatment of hyperlipidemia, we have synthesized some indole derivatives containing a fluvastatin nucleus by methanol mediated Claisen–Schmidt aldol condensation reaction.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="52593176"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="52593176"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 52593176; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=52593176]").text(description); $(".js-view-count[data-work-id=52593176]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 52593176; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='52593176']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 52593176, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=52593176]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":52593176,"title":"Synthesis, crystal studies and in vivo anti-hyperlipidemic activities of indole derivatives containing fluvastatin nucleus","translated_title":"","metadata":{"abstract":"As a part of our efforts to prepare better analogues of fluvastatin for the treatment of hyperlipidemia, we have synthesized some indole derivatives containing a fluvastatin nucleus by methanol mediated Claisen–Schmidt aldol condensation reaction.","publisher":"Royal Society of Chemistry (RSC)","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"RSC Adv."},"translated_abstract":"As a part of our efforts to prepare better analogues of fluvastatin for the treatment of hyperlipidemia, we have synthesized some indole derivatives containing a fluvastatin nucleus by methanol mediated Claisen–Schmidt aldol condensation reaction.","internal_url":"https://www.academia.edu/52593176/Synthesis_crystal_studies_and_in_vivo_anti_hyperlipidemic_activities_of_indole_derivatives_containing_fluvastatin_nucleus","translated_internal_url":"","created_at":"2021-09-16T23:31:09.021-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":327642,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Synthesis_crystal_studies_and_in_vivo_anti_hyperlipidemic_activities_of_indole_derivatives_containing_fluvastatin_nucleus","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"As a part of our efforts to prepare better analogues of fluvastatin for the treatment of hyperlipidemia, we have synthesized some indole derivatives containing a fluvastatin nucleus by methanol mediated Claisen–Schmidt aldol condensation reaction.","owner":{"id":327642,"first_name":"Umesha","middle_initials":null,"last_name":"Katrahalli","page_name":"UmeshaKatrahalli","domain_name":"independent","created_at":"2011-02-09T18:09:32.699-08:00","display_name":"Umesha Katrahalli","url":"https://independent.academia.edu/UmeshaKatrahalli"},"attachments":[],"research_interests":[{"id":191586,"name":"RSC","url":"https://www.academia.edu/Documents/in/RSC"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="52593175"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/52593175/The_effect_of_anti_tubercular_drug_ethionamide_on_the_secondary_structure_of_serum_albumins_A_biophysical_study"><img alt="Research paper thumbnail of The effect of anti-tubercular drug, ethionamide on the secondary structure of serum albumins: A biophysical study" class="work-thumbnail" src="https://attachments.academia-assets.com/69785118/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/52593175/The_effect_of_anti_tubercular_drug_ethionamide_on_the_secondary_structure_of_serum_albumins_A_biophysical_study">The effect of anti-tubercular drug, ethionamide on the secondary structure of serum albumins: A biophysical study</a></div><div class="wp-workCard_item"><span>Journal of Pharmaceutical and Biomedical Analysis</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Serum albumin (SA) is the principal extra cellular protein with higher concentration in the blood...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Serum albumin (SA) is the principal extra cellular protein with higher concentration in the blood plasma and acts as a carrier for many drugs to different molecular targets. The present work is designed to investigate the mechanism of interaction between the protein and an anti-tubercular drug, ethionamide (ETH) at the physiological pH by different molecular spectroscopic techniques viz., fluorescence, UV absorption, CD and FTIR. The interaction of SA with ETH was studied by following the quenching of intrinsic fluorescence of protein by ETH at different temperatures. The Stern-Volmer quenching constant, binding constant and the binding site numbers were calculated from fluorescence results. The results indicated the presence of static quenching mechanism in both HSA-ETH and BSA-ETH systems. The distances of separation between the acceptor and donor were calculated based on the theory of fluorescence resonance energy transfer and were found to be 2.35 nm and 2.18 nm for HSA-ETH and BSA-ETH systems, respectively. The conformational changes in protein were confirmed from UV absorption, CD and FTIR spectral data. Displacement experiments with different site probes revealed that the site I was the main binding site for ETH in protein. Effect of some metal ions was also investigated.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b14b8cc560cc6760abd86d67784aae26" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":69785118,"asset_id":52593175,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/69785118/download_file?st=MTczNzI1ODQyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="52593175"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="52593175"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 52593175; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=52593175]").text(description); $(".js-view-count[data-work-id=52593175]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 52593175; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='52593175']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 52593175, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b14b8cc560cc6760abd86d67784aae26" } } $('.js-work-strip[data-work-id=52593175]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":52593175,"title":"The effect of anti-tubercular drug, ethionamide on the secondary structure of serum albumins: A biophysical study","translated_title":"","metadata":{"publisher":"Elsevier BV","grobid_abstract":"Serum albumin (SA) is the principal extra cellular protein with higher concentration in the blood plasma and acts as a carrier for many drugs to different molecular targets. 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FLX was found to quench the intrinsic fluorescence of protein by static ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="52593174"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="52593174"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 52593174; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=52593174]").text(description); $(".js-view-count[data-work-id=52593174]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 52593174; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='52593174']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 52593174, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=52593174]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":52593174,"title":"Study of the interaction between fluoxetine hydrochloride and bovine serum albumin in the imitated physiological conditions by multi-spectroscopic methods","translated_title":"","metadata":{"abstract":"The mechanism of interaction of an antidepressant, fluoxetine hydrochloride (FLX) with bovine serum albumin (BSA) has been studied by different spectroscopic techniques under physiological conditions. 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FLX was found to quench the intrinsic fluorescence of protein by static ...","owner":{"id":327642,"first_name":"Umesha","middle_initials":null,"last_name":"Katrahalli","page_name":"UmeshaKatrahalli","domain_name":"independent","created_at":"2011-02-09T18:09:32.699-08:00","display_name":"Umesha Katrahalli","url":"https://independent.academia.edu/UmeshaKatrahalli"},"attachments":[],"research_interests":[{"id":5427,"name":"Spectroscopy","url":"https://www.academia.edu/Documents/in/Spectroscopy"},{"id":76408,"name":"Albumin","url":"https://www.academia.edu/Documents/in/Albumin"},{"id":158914,"name":"Luminescence","url":"https://www.academia.edu/Documents/in/Luminescence"},{"id":263152,"name":"Optical physics","url":"https://www.academia.edu/Documents/in/Optical_physics"},{"id":416713,"name":"Spectrometry","url":"https://www.academia.edu/Documents/in/Spectrometry"},{"id":881608,"name":"Bovine Serum Albumin","url":"https://www.academia.edu/Documents/in/Bovine_Serum_Albumin"},{"id":1242506,"name":"Binding Site","url":"https://www.academia.edu/Documents/in/Binding_Site"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="52593173"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/52593173/Synthesis_crystal_studies_anti_tuberculosis_and_cytotoxic_studies_of_1_2E_3_phenylprop_2_enoyl_1H_benzimidazole_derivatives"><img alt="Research paper thumbnail of Synthesis, crystal studies, anti-tuberculosis and cytotoxic studies of 1-[(2E)-3-phenylprop-2-enoyl]-1H-benzimidazole derivatives" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/52593173/Synthesis_crystal_studies_anti_tuberculosis_and_cytotoxic_studies_of_1_2E_3_phenylprop_2_enoyl_1H_benzimidazole_derivatives">Synthesis, crystal studies, anti-tuberculosis and cytotoxic studies of 1-[(2E)-3-phenylprop-2-enoyl]-1H-benzimidazole derivatives</a></div><div class="wp-workCard_item"><span>European Journal of Medicinal Chemistry</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Series of 1-[(2E)-3-phenylprop-2-enoyl]-1H-benzimidazole derivatives were synthesized and charact...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Series of 1-[(2E)-3-phenylprop-2-enoyl]-1H-benzimidazole derivatives were synthesized and characterized by spectral methods. Among 21 derivatives, single crystals of 3a and 3l were grown and their structural parameters were evaluated. Newly synthesized compounds were screened for anti-tubercular activity and the MIC was determined against Mycobacterium tuberculosis H37Rv by Microplate Alamar Blue Assay (MABA) method. Majority of the compounds exhibited a promising inhibition of M. tuberculosis and the molecules functionalized with electron-donating groups at C-2 carbon of benzimidazole moiety were found to be more active in inhibiting M. tuberculosis. Further, more promising compounds viz., 3b, 3i and 3l were tested for their cytotoxic activity. Compound 3l was found to display excellent activity (IC50 &amp;amp;amp;amp;amp;amp;amp;lt; 10 μg mL(-1)) with 100% cell lysis at 30 μg mL(-1) concentration against A549 (Human lung carcinoma) and 8E5 (Human; Acute Lymphoblastic Leukemia) cell lines.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="52593173"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="52593173"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 52593173; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=52593173]").text(description); $(".js-view-count[data-work-id=52593173]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 52593173; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='52593173']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 52593173, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=52593173]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":52593173,"title":"Synthesis, crystal studies, anti-tuberculosis and cytotoxic studies of 1-[(2E)-3-phenylprop-2-enoyl]-1H-benzimidazole derivatives","translated_title":"","metadata":{"abstract":"Series of 1-[(2E)-3-phenylprop-2-enoyl]-1H-benzimidazole derivatives were synthesized and characterized by spectral methods. 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Compound 3l was found to display excellent activity (IC50 \u0026amp;amp;amp;amp;amp;amp;amp;lt; 10 μg mL(-1)) with 100% cell lysis at 30 μg mL(-1) concentration against A549 (Human lung carcinoma) and 8E5 (Human; Acute Lymphoblastic Leukemia) cell lines.","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"European Journal of Medicinal Chemistry"},"translated_abstract":"Series of 1-[(2E)-3-phenylprop-2-enoyl]-1H-benzimidazole derivatives were synthesized and characterized by spectral methods. Among 21 derivatives, single crystals of 3a and 3l were grown and their structural parameters were evaluated. Newly synthesized compounds were screened for anti-tubercular activity and the MIC was determined against Mycobacterium tuberculosis H37Rv by Microplate Alamar Blue Assay (MABA) method. Majority of the compounds exhibited a promising inhibition of M. tuberculosis and the molecules functionalized with electron-donating groups at C-2 carbon of benzimidazole moiety were found to be more active in inhibiting M. tuberculosis. Further, more promising compounds viz., 3b, 3i and 3l were tested for their cytotoxic activity. Compound 3l was found to display excellent activity (IC50 \u0026amp;amp;amp;amp;amp;amp;amp;lt; 10 μg mL(-1)) with 100% cell lysis at 30 μg mL(-1) concentration against A549 (Human lung carcinoma) and 8E5 (Human; Acute Lymphoblastic Leukemia) cell lines.","internal_url":"https://www.academia.edu/52593173/Synthesis_crystal_studies_anti_tuberculosis_and_cytotoxic_studies_of_1_2E_3_phenylprop_2_enoyl_1H_benzimidazole_derivatives","translated_internal_url":"","created_at":"2021-09-16T23:31:08.259-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":327642,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Synthesis_crystal_studies_anti_tuberculosis_and_cytotoxic_studies_of_1_2E_3_phenylprop_2_enoyl_1H_benzimidazole_derivatives","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"Series of 1-[(2E)-3-phenylprop-2-enoyl]-1H-benzimidazole derivatives were synthesized and characterized by spectral methods. Among 21 derivatives, single crystals of 3a and 3l were grown and their structural parameters were evaluated. Newly synthesized compounds were screened for anti-tubercular activity and the MIC was determined against Mycobacterium tuberculosis H37Rv by Microplate Alamar Blue Assay (MABA) method. Majority of the compounds exhibited a promising inhibition of M. tuberculosis and the molecules functionalized with electron-donating groups at C-2 carbon of benzimidazole moiety were found to be more active in inhibiting M. tuberculosis. Further, more promising compounds viz., 3b, 3i and 3l were tested for their cytotoxic activity. Compound 3l was found to display excellent activity (IC50 \u0026amp;amp;amp;amp;amp;amp;amp;lt; 10 μg mL(-1)) with 100% cell lysis at 30 μg mL(-1) concentration against A549 (Human lung carcinoma) and 8E5 (Human; Acute Lymphoblastic Leukemia) cell lines.","owner":{"id":327642,"first_name":"Umesha","middle_initials":null,"last_name":"Katrahalli","page_name":"UmeshaKatrahalli","domain_name":"independent","created_at":"2011-02-09T18:09:32.699-08:00","display_name":"Umesha Katrahalli","url":"https://independent.academia.edu/UmeshaKatrahalli"},"attachments":[],"research_interests":[{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry"},{"id":68318,"name":"Mycobacterium tuberculosis","url":"https://www.academia.edu/Documents/in/Mycobacterium_tuberculosis"},{"id":561014,"name":"Microbial Sensitivity Tests","url":"https://www.academia.edu/Documents/in/Microbial_Sensitivity_Tests"},{"id":782251,"name":"Cell Proliferation","url":"https://www.academia.edu/Documents/in/Cell_Proliferation"},{"id":967839,"name":"Structure activity Relationship","url":"https://www.academia.edu/Documents/in/Structure_activity_Relationship"},{"id":1451703,"name":"Cytotoxins","url":"https://www.academia.edu/Documents/in/Cytotoxins"},{"id":1724844,"name":"Molecular Structure","url":"https://www.academia.edu/Documents/in/Molecular_Structure"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="52593172"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/52593172/Electrochemical_Studies_of_Buzepide_Methiodide_and_their_Analytical_Applications"><img alt="Research paper thumbnail of Electrochemical Studies of Buzepide Methiodide and their Analytical Applications" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/52593172/Electrochemical_Studies_of_Buzepide_Methiodide_and_their_Analytical_Applications">Electrochemical Studies of Buzepide Methiodide and their Analytical Applications</a></div><div class="wp-workCard_item"><span>Int. J. Electrochem …</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">... Analytical Applications Shankara S. Kalanur, Jaldappagari Seetharamappa*, Umesh Katrahalli, P...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... Analytical Applications Shankara S. Kalanur, Jaldappagari Seetharamappa*, Umesh Katrahalli, Pradeep B. Kandagal ... The oxidation and reduction currents were observed to be diffusion controlled between the scan rates of 5 to 500 mV s-1 and 5 to 50 mV s-1, respectively. ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="52593172"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="52593172"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 52593172; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=52593172]").text(description); $(".js-view-count[data-work-id=52593172]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 52593172; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='52593172']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 52593172, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=52593172]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":52593172,"title":"Electrochemical Studies of Buzepide Methiodide and their Analytical Applications","translated_title":"","metadata":{"abstract":"... 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The oxidation and reduction currents were observed to be diffusion controlled between the scan rates of 5 to 500 mV s-1 and 5 to 50 mV s-1, respectively. ...","owner":{"id":327642,"first_name":"Umesha","middle_initials":null,"last_name":"Katrahalli","page_name":"UmeshaKatrahalli","domain_name":"independent","created_at":"2011-02-09T18:09:32.699-08:00","display_name":"Umesha Katrahalli","url":"https://independent.academia.edu/UmeshaKatrahalli"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="436696"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/436696/Study_of_the_Interaction_Between_Fluoxetine_Hydrochloride_and_Bovine_Serum_Albumin_In_the_Imitated_Physiological_Conditions_by_Multi_Spectroscopic_Methods"><img alt="Research paper thumbnail of Study of the Interaction Between Fluoxetine Hydrochloride and Bovine Serum Albumin In the Imitated Physiological Conditions by Multi-Spectroscopic Methods" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/436696/Study_of_the_Interaction_Between_Fluoxetine_Hydrochloride_and_Bovine_Serum_Albumin_In_the_Imitated_Physiological_Conditions_by_Multi_Spectroscopic_Methods">Study of the Interaction Between Fluoxetine Hydrochloride and Bovine Serum Albumin In the Imitated Physiological Conditions by Multi-Spectroscopic Methods</a></div><div class="wp-workCard_item"><span>Journal of Luminescence</span><span>, Jan 1, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The mechanism of interaction of an antidepressant, fluoxetine hydrochloride (FLX) with bovine ser...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The mechanism of interaction of an antidepressant, fluoxetine hydrochloride (FLX) with bovine serum albumin (BSA) has been studied by different spectroscopic techniques under physiological conditions. FLX was found to quench the intrinsic fluorescence of protein by static ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="436696"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="436696"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 436696; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=436696]").text(description); $(".js-view-count[data-work-id=436696]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 436696; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='436696']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 436696, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=436696]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":436696,"title":"Study of the Interaction Between Fluoxetine Hydrochloride and Bovine Serum Albumin In the Imitated Physiological Conditions by Multi-Spectroscopic Methods","translated_title":"","metadata":{"abstract":"The mechanism of interaction of an antidepressant, fluoxetine hydrochloride (FLX) with bovine serum albumin (BSA) has been studied by different spectroscopic techniques under physiological conditions. 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FLX was found to quench the intrinsic fluorescence of protein by static ...","internal_url":"https://www.academia.edu/436696/Study_of_the_Interaction_Between_Fluoxetine_Hydrochloride_and_Bovine_Serum_Albumin_In_the_Imitated_Physiological_Conditions_by_Multi_Spectroscopic_Methods","translated_internal_url":"","created_at":"2011-02-09T18:19:40.559-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":327642,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Study_of_the_Interaction_Between_Fluoxetine_Hydrochloride_and_Bovine_Serum_Albumin_In_the_Imitated_Physiological_Conditions_by_Multi_Spectroscopic_Methods","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"The mechanism of interaction of an antidepressant, fluoxetine hydrochloride (FLX) with bovine serum albumin (BSA) has been studied by different spectroscopic techniques under physiological conditions. FLX was found to quench the intrinsic fluorescence of protein by static ...","owner":{"id":327642,"first_name":"Umesha","middle_initials":null,"last_name":"Katrahalli","page_name":"UmeshaKatrahalli","domain_name":"independent","created_at":"2011-02-09T18:09:32.699-08:00","display_name":"Umesha Katrahalli","url":"https://independent.academia.edu/UmeshaKatrahalli"},"attachments":[],"research_interests":[{"id":158914,"name":"Luminescence","url":"https://www.academia.edu/Documents/in/Luminescence"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="436697"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/436697/Probing_the_Binding_of_Fluoxetine_Hydrochloride_to_Human_Serum_Albumin_by_Multispectroscopic_Techniques"><img alt="Research paper thumbnail of Probing the Binding of Fluoxetine Hydrochloride to Human Serum Albumin by Multispectroscopic Techniques" class="work-thumbnail" src="https://attachments.academia-assets.com/51410445/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/436697/Probing_the_Binding_of_Fluoxetine_Hydrochloride_to_Human_Serum_Albumin_by_Multispectroscopic_Techniques">Probing the Binding of Fluoxetine Hydrochloride to Human Serum Albumin by Multispectroscopic Techniques</a></div><div class="wp-workCard_item"><span>Spectrochimica Acta Part A: …</span><span>, Jan 1, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e6673b95fa7db02b9cf14ecfbd80d1cd" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":51410445,"asset_id":436697,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/51410445/download_file?st=MTczNzI1ODQyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="436697"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="436697"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 436697; 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Results indicated that FLX primarily binds to the hydrophobic pocket in the IIA sub-domain of HSA, causing conformational changes in the protein. Furthermore, the presence of various metal ions influenced the binding constants, highlighting potential implications for drug dosage and therapeutic effectiveness. 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data-work-id="436698"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/436698/Interaction_of_Bioactive_Coomassie_Brilliant_Blue_G_With_Protein_Insights_From_Spectroscopic_Methods"><img alt="Research paper thumbnail of Interaction of Bioactive Coomassie Brilliant Blue G With Protein: Insights From Spectroscopic Methods" class="work-thumbnail" src="https://attachments.academia-assets.com/51410440/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/436698/Interaction_of_Bioactive_Coomassie_Brilliant_Blue_G_With_Protein_Insights_From_Spectroscopic_Methods">Interaction of Bioactive Coomassie Brilliant Blue G With Protein: Insights From Spectroscopic Methods</a></div><div class="wp-workCard_item"><span>Scientia …</span><span>, Jan 1, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The binding of coomassie brilliant blue G (CBB) to bovine serum albumin (BSA) was investigated un...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The binding of coomassie brilliant blue G (CBB) to bovine serum albumin (BSA) was investigated under simulative physiological conditions employing different optical spectroscopic techniques viz., fluorescence emission, UV–visible absorption and FTIR. Fluorescence quenching data obtained at different temperatures suggested the presence of dynamic type of quenching mechanism. The binding constant of CBB-BSA and the number of binding sites (n) for CBB in BSA were calculated and found to be 4.20 × 104 M−1 and 0.96 respectively, at 302 K. The value of n close to unity indicated that the protein has a single class of binding sites for CBB. The thermodynamic parameters revealed that the hydrophobic forces played a major role in the interaction of CBB to BSA. The distance between the CBB and protein was calculated using the theory of Föster’s Resonance Energy Transfer (FRET). The conformational change in the secondary structure of BSA upon interaction with dye was investigated by synchronous fluorescence and FTIR techniques. Competitive binding studies were also carried out to know the location of binding of CBB on BSA.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c54f3d4818af85709beb4c424d09b607" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":51410440,"asset_id":436698,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/51410440/download_file?st=MTczNzI1ODQyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="436698"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="436698"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 436698; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=436698]").text(description); $(".js-view-count[data-work-id=436698]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 436698; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='436698']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 436698, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c54f3d4818af85709beb4c424d09b607" } } $('.js-work-strip[data-work-id=436698]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":436698,"title":"Interaction of Bioactive Coomassie Brilliant Blue G With Protein: Insights From Spectroscopic Methods","translated_title":"","metadata":{"abstract":"The binding of coomassie brilliant blue G (CBB) to bovine serum albumin (BSA) was investigated under simulative physiological conditions employing different optical spectroscopic techniques viz., fluorescence emission, UV–visible absorption and FTIR. 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Competitive binding studies were also carried out to know the location of binding of CBB on BSA.","publisher":"ncbi.nlm.nih.gov","publication_date":{"day":1,"month":1,"year":2010,"errors":{}},"publication_name":"Scientia …"},"translated_abstract":"The binding of coomassie brilliant blue G (CBB) to bovine serum albumin (BSA) was investigated under simulative physiological conditions employing different optical spectroscopic techniques viz., fluorescence emission, UV–visible absorption and FTIR. Fluorescence quenching data obtained at different temperatures suggested the presence of dynamic type of quenching mechanism. The binding constant of CBB-BSA and the number of binding sites (n) for CBB in BSA were calculated and found to be 4.20 × 104 M−1 and 0.96 respectively, at 302 K. The value of n close to unity indicated that the protein has a single class of binding sites for CBB. The thermodynamic parameters revealed that the hydrophobic forces played a major role in the interaction of CBB to BSA. The distance between the CBB and protein was calculated using the theory of Föster’s Resonance Energy Transfer (FRET). The conformational change in the secondary structure of BSA upon interaction with dye was investigated by synchronous fluorescence and FTIR techniques. 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Fluorescence quenching data obtained at different temperatures suggested the presence of dynamic type of quenching mechanism. The binding constant of CBB-BSA and the number of binding sites (n) for CBB in BSA were calculated and found to be 4.20 × 104 M−1 and 0.96 respectively, at 302 K. The value of n close to unity indicated that the protein has a single class of binding sites for CBB. The thermodynamic parameters revealed that the hydrophobic forces played a major role in the interaction of CBB to BSA. The distance between the CBB and protein was calculated using the theory of Föster’s Resonance Energy Transfer (FRET). The conformational change in the secondary structure of BSA upon interaction with dye was investigated by synchronous fluorescence and FTIR techniques. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="436700"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/436700/Electrochemical_Studies_and_Spectroscopic_Investigations_on_the_Interaction_of_An_Anticancer_Drug_With_DNA_and_Their_Analytical_Applications"><img alt="Research paper thumbnail of Electrochemical Studies and Spectroscopic Investigations on the Interaction of An Anticancer Drug With DNA and Their Analytical Applications" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/436700/Electrochemical_Studies_and_Spectroscopic_Investigations_on_the_Interaction_of_An_Anticancer_Drug_With_DNA_and_Their_Analytical_Applications">Electrochemical Studies and Spectroscopic Investigations on the Interaction of An Anticancer Drug With DNA and Their Analytical Applications</a></div><div class="wp-workCard_item"><span>Journal of Electroanalytical …</span><span>, Jan 1, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The electrochemical oxidation of an anticancer drug, gemcitabine hydrochloride (GMB) at glassy ca...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The electrochemical oxidation of an anticancer drug, gemcitabine hydrochloride (GMB) at glassy carbon electrode has been studied by voltammetric techniques. GMB shows one irreversible oxidation peak at 0.927 V in phosphate buffer of pH 7.4. The effect of scan rate, pH, ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="436700"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="436700"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 436700; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=436700]").text(description); $(".js-view-count[data-work-id=436700]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 436700; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='436700']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 436700, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=436700]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":436700,"title":"Electrochemical Studies and Spectroscopic Investigations on the Interaction of An Anticancer Drug With DNA and Their Analytical Applications","translated_title":"","metadata":{"abstract":"The electrochemical oxidation of an anticancer drug, gemcitabine hydrochloride (GMB) at glassy carbon electrode has been studied by voltammetric techniques. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="47389" id="papers"><div class="js-work-strip profile--work_container" data-work-id="96076174"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/96076174/Insights_from_Spectroscopic_Methods"><img alt="Research paper thumbnail of Insights from Spectroscopic Methods" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/96076174/Insights_from_Spectroscopic_Methods">Insights from Spectroscopic Methods</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">This is an Open Access article distributed under the terms of the Creative Commons Attribution Li...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">This is an Open Access article distributed under the terms of the Creative Commons Attribution License</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96076174"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96076174"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96076174; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="96076173"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96076173/Electrochemical_Behavior_of_Xanthene_Food_Dye_Erythrosine_at_Glassy_Carbon_Electrode_and_Its_Analytical_Applications"><img alt="Research paper thumbnail of Electrochemical Behavior of Xanthene Food Dye Erythrosine at Glassy Carbon Electrode and Its Analytical Applications" class="work-thumbnail" src="https://attachments.academia-assets.com/98075455/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96076173/Electrochemical_Behavior_of_Xanthene_Food_Dye_Erythrosine_at_Glassy_Carbon_Electrode_and_Its_Analytical_Applications">Electrochemical Behavior of Xanthene Food Dye Erythrosine at Glassy Carbon Electrode and Its Analytical Applications</a></div><div class="wp-workCard_item"><span>Asian Journal of Pharmaceutical and Clinical Research</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Erythrosine is a xanthene food dye used in the food industries to enhance the appearance of the f...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Erythrosine is a xanthene food dye used in the food industries to enhance the appearance of the food. The electrochemical behavior of erythrosine at glassy carbon electrode was investigated by cyclic and differential pulse voltammetry. The oxidation peak of erythrosine was observed in phosphate buffer of pH 5.0. The influence of different pH, scan rate and concentration were evaluated. The probable reaction mechanism involved in the oxidation of erythrosine was also proposed. Differential pulse voltammetric method with good precision and accuracy was developed for the determination of erythrosine dye in real samples. The peak currents were found to be linearly dependent on the concentration range of 1 x 10 -5 to 6 x 10 -4 M. The limit of detection (LOD) and limit of quantification (LOQ) were noticed to be 1.9 x 10 -7 and 6.6 x 10 -7 M respectively.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="f6ec98119a9c5b9e4d8f4b358a312675" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98075455,"asset_id":96076173,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98075455/download_file?st=MTczNzI1ODQyOCw4LjIyMi4yMDguMTQ2&st=MTczNzI1ODQyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96076173"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96076173"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96076173; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96076173]").text(description); $(".js-view-count[data-work-id=96076173]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96076173; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96076173']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96076173, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "f6ec98119a9c5b9e4d8f4b358a312675" } } $('.js-work-strip[data-work-id=96076173]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96076173,"title":"Electrochemical Behavior of Xanthene Food Dye Erythrosine at Glassy Carbon Electrode and Its Analytical Applications","translated_title":"","metadata":{"abstract":"Erythrosine is a xanthene food dye used in the food industries to enhance the appearance of the food. 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The limit of detection (LOD) and limit of quantification (LOQ) were noticed to be 1.9 x 10 -7 and 6.6 x 10 -7 M respectively.","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Asian Journal of Pharmaceutical and Clinical Research"},"translated_abstract":"Erythrosine is a xanthene food dye used in the food industries to enhance the appearance of the food. The electrochemical behavior of erythrosine at glassy carbon electrode was investigated by cyclic and differential pulse voltammetry. The oxidation peak of erythrosine was observed in phosphate buffer of pH 5.0. The influence of different pH, scan rate and concentration were evaluated. The probable reaction mechanism involved in the oxidation of erythrosine was also proposed. Differential pulse voltammetric method with good precision and accuracy was developed for the determination of erythrosine dye in real samples. The peak currents were found to be linearly dependent on the concentration range of 1 x 10 -5 to 6 x 10 -4 M. 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FLX was found to quench the intrinsic fluorescence of protein by static ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="52593179"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="52593179"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 52593179; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=52593179]").text(description); $(".js-view-count[data-work-id=52593179]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 52593179; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='52593179']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 52593179, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=52593179]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":52593179,"title":"Study of the interaction between fluoxetine hydrochloride and bovine serum albumin in the imitated physiological conditions by multi-spectroscopic methods","translated_title":"","metadata":{"abstract":"The mechanism of interaction of an antidepressant, fluoxetine hydrochloride (FLX) with bovine serum albumin (BSA) has been studied by different spectroscopic techniques under physiological conditions. 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FLX was found to quench the intrinsic fluorescence of protein by static ...","owner":{"id":327642,"first_name":"Umesha","middle_initials":null,"last_name":"Katrahalli","page_name":"UmeshaKatrahalli","domain_name":"independent","created_at":"2011-02-09T18:09:32.699-08:00","display_name":"Umesha Katrahalli","url":"https://independent.academia.edu/UmeshaKatrahalli"},"attachments":[],"research_interests":[{"id":5427,"name":"Spectroscopy","url":"https://www.academia.edu/Documents/in/Spectroscopy"},{"id":76408,"name":"Albumin","url":"https://www.academia.edu/Documents/in/Albumin"},{"id":158914,"name":"Luminescence","url":"https://www.academia.edu/Documents/in/Luminescence"},{"id":263152,"name":"Optical physics","url":"https://www.academia.edu/Documents/in/Optical_physics"},{"id":416713,"name":"Spectrometry","url":"https://www.academia.edu/Documents/in/Spectrometry"},{"id":881608,"name":"Bovine Serum Albumin","url":"https://www.academia.edu/Documents/in/Bovine_Serum_Albumin"},{"id":1242506,"name":"Binding Site","url":"https://www.academia.edu/Documents/in/Binding_Site"}],"urls":[{"id":11254611,"url":"http://adsabs.harvard.edu/abs/2010jlum..130..211k"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="52593178"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/52593178/Voltammetric_and_spectroscopic_investigations_on_the_mechanism_of_interaction_of_buzepide_methiodide_with_protein"><img alt="Research paper thumbnail of Voltammetric and spectroscopic investigations on the mechanism of interaction of buzepide methiodide with protein" class="work-thumbnail" src="https://attachments.academia-assets.com/69785192/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/52593178/Voltammetric_and_spectroscopic_investigations_on_the_mechanism_of_interaction_of_buzepide_methiodide_with_protein">Voltammetric and spectroscopic investigations on the mechanism of interaction of buzepide methiodide with protein</a></div><div class="wp-workCard_item"><span>Colloids and Surfaces B Biointerfaces</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Adsorption or immobilization of proteins on solid surfaces promotes the biological responses to m...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Adsorption or immobilization of proteins on solid surfaces promotes the biological responses to materials. Using immobilization technique, we have prepared human serum albumin (HSA) modified glassy carbon electrode (GCE) and employed it to probe the mode of interaction between antidepressant drug, buzepide methiodide (BZP) and HSA. At HSA modified GCE, the peak potential of BZP appeared at more positive potential compared to that at bare electrode thereby indicating the hydrophobic mode of interaction between BZP and HSA. Peak currents of BZP decreased upon the addition of HSA at bare GCE with positive shift in peak potential. Further, no new peaks were observed in presence of HSA. From electrochemical data, the binding constant and binding ratio between HSA and BZP were calculated to be 9.33 × 10 6 M −1 and 1:2, respectively. FT-IR and circular dichroism (CD) studies revealed that the secondary structure of protein was perturbed upon interaction with BZP.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="6979eb0257b54818d586e266d936939c" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":69785192,"asset_id":52593178,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/69785192/download_file?st=MTczNzI1ODQyOCw4LjIyMi4yMDguMTQ2&st=MTczNzI1ODQyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="52593178"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="52593178"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 52593178; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=52593178]").text(description); $(".js-view-count[data-work-id=52593178]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 52593178; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='52593178']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 52593178, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "6979eb0257b54818d586e266d936939c" } } $('.js-work-strip[data-work-id=52593178]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":52593178,"title":"Voltammetric and spectroscopic investigations on the mechanism of interaction of buzepide methiodide with protein","translated_title":"","metadata":{"grobid_abstract":"Adsorption or immobilization of proteins on solid surfaces promotes the biological responses to materials. 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FT-IR and circular dichroism (CD) studies revealed that the secondary structure of protein was perturbed upon interaction with BZP.","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"publication_name":"Colloids and Surfaces B Biointerfaces","grobid_abstract_attachment_id":69785192},"translated_abstract":null,"internal_url":"https://www.academia.edu/52593178/Voltammetric_and_spectroscopic_investigations_on_the_mechanism_of_interaction_of_buzepide_methiodide_with_protein","translated_internal_url":"","created_at":"2021-09-16T23:31:09.218-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":327642,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":69785192,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/69785192/thumbnails/1.jpg","file_name":"j.colsurfb.2009.08.01120210916-6241-1iqddpu.pdf","download_url":"https://www.academia.edu/attachments/69785192/download_file?st=MTczNzI1ODQyOCw4LjIyMi4yMDguMTQ2&st=MTczNzI1ODQyOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Voltammetric_and_spectroscopic_investiga.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/69785192/j.colsurfb.2009.08.01120210916-6241-1iqddpu-libre.pdf?1631861300=\u0026response-content-disposition=attachment%3B+filename%3DVoltammetric_and_spectroscopic_investiga.pdf\u0026Expires=1737262028\u0026Signature=Tl6PolcLyCbS86OKvJ6kqaI6EBBo6a1VJG1NHdi3ipFyvkpLvX2nI4k7uyEFbTJsPVzK-JrhA~3wqQ-UjOyeStmmLF0WfmelRbJB4cXtsWbcDu65d0pzq-1E6dkJCR8Z3rt6hOYpeqZP0xZvlfTHizmB6drIVdf42lGGHLAwr3ulOySr-BAgeDgJo40bcU2jfK1A8hrihVYRr3nYTZ-OzBIAQaPuw1XkJ4eWl8zJkavIcpg9Jj1eqN99ADsv8kNunjta8ODJ~TMIEIK6Ap11s84bD2uC41rghvB55gIp5o9IjSM0xbaGl9XimXFBcSPdT1Ty8~NoPENdKhWsV2B~0Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Voltammetric_and_spectroscopic_investigations_on_the_mechanism_of_interaction_of_buzepide_methiodide_with_protein","translated_slug":"","page_count":5,"language":"en","content_type":"Work","summary":"Adsorption or immobilization of proteins on solid surfaces promotes the biological responses to materials. Using immobilization technique, we have prepared human serum albumin (HSA) modified glassy carbon electrode (GCE) and employed it to probe the mode of interaction between antidepressant drug, buzepide methiodide (BZP) and HSA. At HSA modified GCE, the peak potential of BZP appeared at more positive potential compared to that at bare electrode thereby indicating the hydrophobic mode of interaction between BZP and HSA. Peak currents of BZP decreased upon the addition of HSA at bare GCE with positive shift in peak potential. Further, no new peaks were observed in presence of HSA. From electrochemical data, the binding constant and binding ratio between HSA and BZP were calculated to be 9.33 × 10 6 M −1 and 1:2, respectively. FT-IR and circular dichroism (CD) studies revealed that the secondary structure of protein was perturbed upon interaction with BZP.","owner":{"id":327642,"first_name":"Umesha","middle_initials":null,"last_name":"Katrahalli","page_name":"UmeshaKatrahalli","domain_name":"independent","created_at":"2011-02-09T18:09:32.699-08:00","display_name":"Umesha Katrahalli","url":"https://independent.academia.edu/UmeshaKatrahalli"},"attachments":[{"id":69785192,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/69785192/thumbnails/1.jpg","file_name":"j.colsurfb.2009.08.01120210916-6241-1iqddpu.pdf","download_url":"https://www.academia.edu/attachments/69785192/download_file?st=MTczNzI1ODQyOCw4LjIyMi4yMDguMTQ2&st=MTczNzI1ODQyOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Voltammetric_and_spectroscopic_investiga.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/69785192/j.colsurfb.2009.08.01120210916-6241-1iqddpu-libre.pdf?1631861300=\u0026response-content-disposition=attachment%3B+filename%3DVoltammetric_and_spectroscopic_investiga.pdf\u0026Expires=1737262028\u0026Signature=Tl6PolcLyCbS86OKvJ6kqaI6EBBo6a1VJG1NHdi3ipFyvkpLvX2nI4k7uyEFbTJsPVzK-JrhA~3wqQ-UjOyeStmmLF0WfmelRbJB4cXtsWbcDu65d0pzq-1E6dkJCR8Z3rt6hOYpeqZP0xZvlfTHizmB6drIVdf42lGGHLAwr3ulOySr-BAgeDgJo40bcU2jfK1A8hrihVYRr3nYTZ-OzBIAQaPuw1XkJ4eWl8zJkavIcpg9Jj1eqN99ADsv8kNunjta8ODJ~TMIEIK6Ap11s84bD2uC41rghvB55gIp5o9IjSM0xbaGl9XimXFBcSPdT1Ty8~NoPENdKhWsV2B~0Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":72,"name":"Chemical Engineering","url":"https://www.academia.edu/Documents/in/Chemical_Engineering"},{"id":1131,"name":"Biomedical Engineering","url":"https://www.academia.edu/Documents/in/Biomedical_Engineering"},{"id":5303,"name":"Carbon","url":"https://www.academia.edu/Documents/in/Carbon"},{"id":7742,"name":"Glass","url":"https://www.academia.edu/Documents/in/Glass"},{"id":76407,"name":"Circular Dichroism","url":"https://www.academia.edu/Documents/in/Circular_Dichroism"},{"id":337175,"name":"Secondary Structure","url":"https://www.academia.edu/Documents/in/Secondary_Structure"},{"id":398650,"name":"Fourier transform infrared spectroscopy","url":"https://www.academia.edu/Documents/in/Fourier_transform_infrared_spectroscopy"},{"id":414692,"name":"Solutions","url":"https://www.academia.edu/Documents/in/Solutions"},{"id":846015,"name":"Electrodes","url":"https://www.academia.edu/Documents/in/Electrodes"},{"id":2349258,"name":"Serum albumin","url":"https://www.academia.edu/Documents/in/Serum_albumin"},{"id":3686577,"name":"Human serum albumin","url":"https://www.academia.edu/Documents/in/Human_serum_albumin"}],"urls":[{"id":11254610,"url":"http://cat.inist.fr/?aModele=afficheN\u0026cpsidt=22273622"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="52593177"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/52593177/Mechanistic_and_conformational_studies_on_the_interaction_of_anti_inflammatory_drugs_isoxicam_and_tenoxicam_with_bovine_serum_albumin"><img alt="Research paper thumbnail of Mechanistic and conformational studies on the interaction of anti-inflammatory drugs, isoxicam and tenoxicam with bovine serum albumin" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/52593177/Mechanistic_and_conformational_studies_on_the_interaction_of_anti_inflammatory_drugs_isoxicam_and_tenoxicam_with_bovine_serum_albumin">Mechanistic and conformational studies on the interaction of anti-inflammatory drugs, isoxicam and tenoxicam with bovine serum albumin</a></div><div class="wp-workCard_item"><span>Journal of Luminescence</span><span>, Nov 1, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The mechanism of interaction of the non-steroidal anti-inflammatory drugs, isoxicam (IXM) and ten...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The mechanism of interaction of the non-steroidal anti-inflammatory drugs, isoxicam (IXM) and tenoxicam (TXM) with bovine serum albumin (BSA) has been studied using spectroscopic techniques viz., spectrofluorescence, circular dichroism (CD), UV-Visible absorption and FT-IR under ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="52593177"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="52593177"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 52593177; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=52593177]").text(description); $(".js-view-count[data-work-id=52593177]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 52593177; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='52593177']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 52593177, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="52593176"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/52593176/Synthesis_crystal_studies_and_in_vivo_anti_hyperlipidemic_activities_of_indole_derivatives_containing_fluvastatin_nucleus"><img alt="Research paper thumbnail of Synthesis, crystal studies and in vivo anti-hyperlipidemic activities of indole derivatives containing fluvastatin nucleus" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/52593176/Synthesis_crystal_studies_and_in_vivo_anti_hyperlipidemic_activities_of_indole_derivatives_containing_fluvastatin_nucleus">Synthesis, crystal studies and in vivo anti-hyperlipidemic activities of indole derivatives containing fluvastatin nucleus</a></div><div class="wp-workCard_item"><span>RSC Adv.</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">As a part of our efforts to prepare better analogues of fluvastatin for the treatment of hyperlip...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">As a part of our efforts to prepare better analogues of fluvastatin for the treatment of hyperlipidemia, we have synthesized some indole derivatives containing a fluvastatin nucleus by methanol mediated Claisen–Schmidt aldol condensation reaction.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="52593176"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="52593176"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 52593176; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=52593176]").text(description); $(".js-view-count[data-work-id=52593176]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 52593176; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='52593176']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 52593176, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=52593176]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":52593176,"title":"Synthesis, crystal studies and in vivo anti-hyperlipidemic activities of indole derivatives containing fluvastatin nucleus","translated_title":"","metadata":{"abstract":"As a part of our efforts to prepare better analogues of fluvastatin for the treatment of hyperlipidemia, we have synthesized some indole derivatives containing a fluvastatin nucleus by methanol mediated Claisen–Schmidt aldol condensation reaction.","publisher":"Royal Society of Chemistry (RSC)","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"RSC Adv."},"translated_abstract":"As a part of our efforts to prepare better analogues of fluvastatin for the treatment of hyperlipidemia, we have synthesized some indole derivatives containing a fluvastatin nucleus by methanol mediated Claisen–Schmidt aldol condensation reaction.","internal_url":"https://www.academia.edu/52593176/Synthesis_crystal_studies_and_in_vivo_anti_hyperlipidemic_activities_of_indole_derivatives_containing_fluvastatin_nucleus","translated_internal_url":"","created_at":"2021-09-16T23:31:09.021-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":327642,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Synthesis_crystal_studies_and_in_vivo_anti_hyperlipidemic_activities_of_indole_derivatives_containing_fluvastatin_nucleus","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"As a part of our efforts to prepare better analogues of fluvastatin for the treatment of hyperlipidemia, we have synthesized some indole derivatives containing a fluvastatin nucleus by methanol mediated Claisen–Schmidt aldol condensation reaction.","owner":{"id":327642,"first_name":"Umesha","middle_initials":null,"last_name":"Katrahalli","page_name":"UmeshaKatrahalli","domain_name":"independent","created_at":"2011-02-09T18:09:32.699-08:00","display_name":"Umesha Katrahalli","url":"https://independent.academia.edu/UmeshaKatrahalli"},"attachments":[],"research_interests":[{"id":191586,"name":"RSC","url":"https://www.academia.edu/Documents/in/RSC"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="52593175"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/52593175/The_effect_of_anti_tubercular_drug_ethionamide_on_the_secondary_structure_of_serum_albumins_A_biophysical_study"><img alt="Research paper thumbnail of The effect of anti-tubercular drug, ethionamide on the secondary structure of serum albumins: A biophysical study" class="work-thumbnail" src="https://attachments.academia-assets.com/69785118/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/52593175/The_effect_of_anti_tubercular_drug_ethionamide_on_the_secondary_structure_of_serum_albumins_A_biophysical_study">The effect of anti-tubercular drug, ethionamide on the secondary structure of serum albumins: A biophysical study</a></div><div class="wp-workCard_item"><span>Journal of Pharmaceutical and Biomedical Analysis</span><span>, 2012</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Serum albumin (SA) is the principal extra cellular protein with higher concentration in the blood...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Serum albumin (SA) is the principal extra cellular protein with higher concentration in the blood plasma and acts as a carrier for many drugs to different molecular targets. The present work is designed to investigate the mechanism of interaction between the protein and an anti-tubercular drug, ethionamide (ETH) at the physiological pH by different molecular spectroscopic techniques viz., fluorescence, UV absorption, CD and FTIR. The interaction of SA with ETH was studied by following the quenching of intrinsic fluorescence of protein by ETH at different temperatures. The Stern-Volmer quenching constant, binding constant and the binding site numbers were calculated from fluorescence results. The results indicated the presence of static quenching mechanism in both HSA-ETH and BSA-ETH systems. The distances of separation between the acceptor and donor were calculated based on the theory of fluorescence resonance energy transfer and were found to be 2.35 nm and 2.18 nm for HSA-ETH and BSA-ETH systems, respectively. The conformational changes in protein were confirmed from UV absorption, CD and FTIR spectral data. Displacement experiments with different site probes revealed that the site I was the main binding site for ETH in protein. Effect of some metal ions was also investigated.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="b14b8cc560cc6760abd86d67784aae26" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":69785118,"asset_id":52593175,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/69785118/download_file?st=MTczNzI1ODQyOCw4LjIyMi4yMDguMTQ2&st=MTczNzI1ODQyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="52593175"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="52593175"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 52593175; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=52593175]").text(description); $(".js-view-count[data-work-id=52593175]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 52593175; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='52593175']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 52593175, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "b14b8cc560cc6760abd86d67784aae26" } } $('.js-work-strip[data-work-id=52593175]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":52593175,"title":"The effect of anti-tubercular drug, ethionamide on the secondary structure of serum albumins: A biophysical study","translated_title":"","metadata":{"publisher":"Elsevier BV","grobid_abstract":"Serum albumin (SA) is the principal extra cellular protein with higher concentration in the blood plasma and acts as a carrier for many drugs to different molecular targets. 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FLX was found to quench the intrinsic fluorescence of protein by static ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="52593174"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="52593174"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 52593174; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=52593174]").text(description); $(".js-view-count[data-work-id=52593174]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 52593174; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='52593174']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 52593174, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=52593174]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":52593174,"title":"Study of the interaction between fluoxetine hydrochloride and bovine serum albumin in the imitated physiological conditions by multi-spectroscopic methods","translated_title":"","metadata":{"abstract":"The mechanism of interaction of an antidepressant, fluoxetine hydrochloride (FLX) with bovine serum albumin (BSA) has been studied by different spectroscopic techniques under physiological conditions. 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FLX was found to quench the intrinsic fluorescence of protein by static ...","owner":{"id":327642,"first_name":"Umesha","middle_initials":null,"last_name":"Katrahalli","page_name":"UmeshaKatrahalli","domain_name":"independent","created_at":"2011-02-09T18:09:32.699-08:00","display_name":"Umesha Katrahalli","url":"https://independent.academia.edu/UmeshaKatrahalli"},"attachments":[],"research_interests":[{"id":5427,"name":"Spectroscopy","url":"https://www.academia.edu/Documents/in/Spectroscopy"},{"id":76408,"name":"Albumin","url":"https://www.academia.edu/Documents/in/Albumin"},{"id":158914,"name":"Luminescence","url":"https://www.academia.edu/Documents/in/Luminescence"},{"id":263152,"name":"Optical physics","url":"https://www.academia.edu/Documents/in/Optical_physics"},{"id":416713,"name":"Spectrometry","url":"https://www.academia.edu/Documents/in/Spectrometry"},{"id":881608,"name":"Bovine Serum Albumin","url":"https://www.academia.edu/Documents/in/Bovine_Serum_Albumin"},{"id":1242506,"name":"Binding Site","url":"https://www.academia.edu/Documents/in/Binding_Site"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="52593173"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/52593173/Synthesis_crystal_studies_anti_tuberculosis_and_cytotoxic_studies_of_1_2E_3_phenylprop_2_enoyl_1H_benzimidazole_derivatives"><img alt="Research paper thumbnail of Synthesis, crystal studies, anti-tuberculosis and cytotoxic studies of 1-[(2E)-3-phenylprop-2-enoyl]-1H-benzimidazole derivatives" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/52593173/Synthesis_crystal_studies_anti_tuberculosis_and_cytotoxic_studies_of_1_2E_3_phenylprop_2_enoyl_1H_benzimidazole_derivatives">Synthesis, crystal studies, anti-tuberculosis and cytotoxic studies of 1-[(2E)-3-phenylprop-2-enoyl]-1H-benzimidazole derivatives</a></div><div class="wp-workCard_item"><span>European Journal of Medicinal Chemistry</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Series of 1-[(2E)-3-phenylprop-2-enoyl]-1H-benzimidazole derivatives were synthesized and charact...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Series of 1-[(2E)-3-phenylprop-2-enoyl]-1H-benzimidazole derivatives were synthesized and characterized by spectral methods. Among 21 derivatives, single crystals of 3a and 3l were grown and their structural parameters were evaluated. Newly synthesized compounds were screened for anti-tubercular activity and the MIC was determined against Mycobacterium tuberculosis H37Rv by Microplate Alamar Blue Assay (MABA) method. Majority of the compounds exhibited a promising inhibition of M. tuberculosis and the molecules functionalized with electron-donating groups at C-2 carbon of benzimidazole moiety were found to be more active in inhibiting M. tuberculosis. Further, more promising compounds viz., 3b, 3i and 3l were tested for their cytotoxic activity. Compound 3l was found to display excellent activity (IC50 &amp;amp;amp;amp;amp;amp;amp;lt; 10 μg mL(-1)) with 100% cell lysis at 30 μg mL(-1) concentration against A549 (Human lung carcinoma) and 8E5 (Human; Acute Lymphoblastic Leukemia) cell lines.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="52593173"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="52593173"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 52593173; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=52593173]").text(description); $(".js-view-count[data-work-id=52593173]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 52593173; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='52593173']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 52593173, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=52593173]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":52593173,"title":"Synthesis, crystal studies, anti-tuberculosis and cytotoxic studies of 1-[(2E)-3-phenylprop-2-enoyl]-1H-benzimidazole derivatives","translated_title":"","metadata":{"abstract":"Series of 1-[(2E)-3-phenylprop-2-enoyl]-1H-benzimidazole derivatives were synthesized and characterized by spectral methods. 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Compound 3l was found to display excellent activity (IC50 \u0026amp;amp;amp;amp;amp;amp;amp;lt; 10 μg mL(-1)) with 100% cell lysis at 30 μg mL(-1) concentration against A549 (Human lung carcinoma) and 8E5 (Human; Acute Lymphoblastic Leukemia) cell lines.","publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"European Journal of Medicinal Chemistry"},"translated_abstract":"Series of 1-[(2E)-3-phenylprop-2-enoyl]-1H-benzimidazole derivatives were synthesized and characterized by spectral methods. Among 21 derivatives, single crystals of 3a and 3l were grown and their structural parameters were evaluated. Newly synthesized compounds were screened for anti-tubercular activity and the MIC was determined against Mycobacterium tuberculosis H37Rv by Microplate Alamar Blue Assay (MABA) method. Majority of the compounds exhibited a promising inhibition of M. tuberculosis and the molecules functionalized with electron-donating groups at C-2 carbon of benzimidazole moiety were found to be more active in inhibiting M. tuberculosis. Further, more promising compounds viz., 3b, 3i and 3l were tested for their cytotoxic activity. Compound 3l was found to display excellent activity (IC50 \u0026amp;amp;amp;amp;amp;amp;amp;lt; 10 μg mL(-1)) with 100% cell lysis at 30 μg mL(-1) concentration against A549 (Human lung carcinoma) and 8E5 (Human; Acute Lymphoblastic Leukemia) cell lines.","internal_url":"https://www.academia.edu/52593173/Synthesis_crystal_studies_anti_tuberculosis_and_cytotoxic_studies_of_1_2E_3_phenylprop_2_enoyl_1H_benzimidazole_derivatives","translated_internal_url":"","created_at":"2021-09-16T23:31:08.259-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":327642,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Synthesis_crystal_studies_anti_tuberculosis_and_cytotoxic_studies_of_1_2E_3_phenylprop_2_enoyl_1H_benzimidazole_derivatives","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"Series of 1-[(2E)-3-phenylprop-2-enoyl]-1H-benzimidazole derivatives were synthesized and characterized by spectral methods. Among 21 derivatives, single crystals of 3a and 3l were grown and their structural parameters were evaluated. Newly synthesized compounds were screened for anti-tubercular activity and the MIC was determined against Mycobacterium tuberculosis H37Rv by Microplate Alamar Blue Assay (MABA) method. Majority of the compounds exhibited a promising inhibition of M. tuberculosis and the molecules functionalized with electron-donating groups at C-2 carbon of benzimidazole moiety were found to be more active in inhibiting M. tuberculosis. Further, more promising compounds viz., 3b, 3i and 3l were tested for their cytotoxic activity. Compound 3l was found to display excellent activity (IC50 \u0026amp;amp;amp;amp;amp;amp;amp;lt; 10 μg mL(-1)) with 100% cell lysis at 30 μg mL(-1) concentration against A549 (Human lung carcinoma) and 8E5 (Human; Acute Lymphoblastic Leukemia) cell lines.","owner":{"id":327642,"first_name":"Umesha","middle_initials":null,"last_name":"Katrahalli","page_name":"UmeshaKatrahalli","domain_name":"independent","created_at":"2011-02-09T18:09:32.699-08:00","display_name":"Umesha Katrahalli","url":"https://independent.academia.edu/UmeshaKatrahalli"},"attachments":[],"research_interests":[{"id":531,"name":"Organic Chemistry","url":"https://www.academia.edu/Documents/in/Organic_Chemistry"},{"id":68318,"name":"Mycobacterium tuberculosis","url":"https://www.academia.edu/Documents/in/Mycobacterium_tuberculosis"},{"id":561014,"name":"Microbial Sensitivity Tests","url":"https://www.academia.edu/Documents/in/Microbial_Sensitivity_Tests"},{"id":782251,"name":"Cell Proliferation","url":"https://www.academia.edu/Documents/in/Cell_Proliferation"},{"id":967839,"name":"Structure activity Relationship","url":"https://www.academia.edu/Documents/in/Structure_activity_Relationship"},{"id":1451703,"name":"Cytotoxins","url":"https://www.academia.edu/Documents/in/Cytotoxins"},{"id":1724844,"name":"Molecular Structure","url":"https://www.academia.edu/Documents/in/Molecular_Structure"},{"id":3789884,"name":"Pharmacology and pharmaceutical sciences","url":"https://www.academia.edu/Documents/in/Pharmacology_and_pharmaceutical_sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="52593172"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/52593172/Electrochemical_Studies_of_Buzepide_Methiodide_and_their_Analytical_Applications"><img alt="Research paper thumbnail of Electrochemical Studies of Buzepide Methiodide and their Analytical Applications" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/52593172/Electrochemical_Studies_of_Buzepide_Methiodide_and_their_Analytical_Applications">Electrochemical Studies of Buzepide Methiodide and their Analytical Applications</a></div><div class="wp-workCard_item"><span>Int. J. Electrochem …</span><span>, 2008</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">... Analytical Applications Shankara S. Kalanur, Jaldappagari Seetharamappa*, Umesh Katrahalli, P...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">... Analytical Applications Shankara S. Kalanur, Jaldappagari Seetharamappa*, Umesh Katrahalli, Pradeep B. Kandagal ... The oxidation and reduction currents were observed to be diffusion controlled between the scan rates of 5 to 500 mV s-1 and 5 to 50 mV s-1, respectively. ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="52593172"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="52593172"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 52593172; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=52593172]").text(description); $(".js-view-count[data-work-id=52593172]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 52593172; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='52593172']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 52593172, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=52593172]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":52593172,"title":"Electrochemical Studies of Buzepide Methiodide and their Analytical Applications","translated_title":"","metadata":{"abstract":"... 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The oxidation and reduction currents were observed to be diffusion controlled between the scan rates of 5 to 500 mV s-1 and 5 to 50 mV s-1, respectively. ...","owner":{"id":327642,"first_name":"Umesha","middle_initials":null,"last_name":"Katrahalli","page_name":"UmeshaKatrahalli","domain_name":"independent","created_at":"2011-02-09T18:09:32.699-08:00","display_name":"Umesha Katrahalli","url":"https://independent.academia.edu/UmeshaKatrahalli"},"attachments":[],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="436696"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/436696/Study_of_the_Interaction_Between_Fluoxetine_Hydrochloride_and_Bovine_Serum_Albumin_In_the_Imitated_Physiological_Conditions_by_Multi_Spectroscopic_Methods"><img alt="Research paper thumbnail of Study of the Interaction Between Fluoxetine Hydrochloride and Bovine Serum Albumin In the Imitated Physiological Conditions by Multi-Spectroscopic Methods" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/436696/Study_of_the_Interaction_Between_Fluoxetine_Hydrochloride_and_Bovine_Serum_Albumin_In_the_Imitated_Physiological_Conditions_by_Multi_Spectroscopic_Methods">Study of the Interaction Between Fluoxetine Hydrochloride and Bovine Serum Albumin In the Imitated Physiological Conditions by Multi-Spectroscopic Methods</a></div><div class="wp-workCard_item"><span>Journal of Luminescence</span><span>, Jan 1, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The mechanism of interaction of an antidepressant, fluoxetine hydrochloride (FLX) with bovine ser...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The mechanism of interaction of an antidepressant, fluoxetine hydrochloride (FLX) with bovine serum albumin (BSA) has been studied by different spectroscopic techniques under physiological conditions. FLX was found to quench the intrinsic fluorescence of protein by static ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="436696"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="436696"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 436696; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=436696]").text(description); $(".js-view-count[data-work-id=436696]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 436696; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='436696']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 436696, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=436696]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":436696,"title":"Study of the Interaction Between Fluoxetine Hydrochloride and Bovine Serum Albumin In the Imitated Physiological Conditions by Multi-Spectroscopic Methods","translated_title":"","metadata":{"abstract":"The mechanism of interaction of an antidepressant, fluoxetine hydrochloride (FLX) with bovine serum albumin (BSA) has been studied by different spectroscopic techniques under physiological conditions. 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FLX was found to quench the intrinsic fluorescence of protein by static ...","owner":{"id":327642,"first_name":"Umesha","middle_initials":null,"last_name":"Katrahalli","page_name":"UmeshaKatrahalli","domain_name":"independent","created_at":"2011-02-09T18:09:32.699-08:00","display_name":"Umesha Katrahalli","url":"https://independent.academia.edu/UmeshaKatrahalli"},"attachments":[],"research_interests":[{"id":158914,"name":"Luminescence","url":"https://www.academia.edu/Documents/in/Luminescence"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="436697"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/436697/Probing_the_Binding_of_Fluoxetine_Hydrochloride_to_Human_Serum_Albumin_by_Multispectroscopic_Techniques"><img alt="Research paper thumbnail of Probing the Binding of Fluoxetine Hydrochloride to Human Serum Albumin by Multispectroscopic Techniques" class="work-thumbnail" src="https://attachments.academia-assets.com/51410445/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/436697/Probing_the_Binding_of_Fluoxetine_Hydrochloride_to_Human_Serum_Albumin_by_Multispectroscopic_Techniques">Probing the Binding of Fluoxetine Hydrochloride to Human Serum Albumin by Multispectroscopic Techniques</a></div><div class="wp-workCard_item"><span>Spectrochimica Acta Part A: …</span><span>, Jan 1, 2010</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="e6673b95fa7db02b9cf14ecfbd80d1cd" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":51410445,"asset_id":436697,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/51410445/download_file?st=MTczNzI1ODQyOCw4LjIyMi4yMDguMTQ2&st=MTczNzI1ODQyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="436697"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="436697"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 436697; 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Results indicated that FLX primarily binds to the hydrophobic pocket in the IIA sub-domain of HSA, causing conformational changes in the protein. Furthermore, the presence of various metal ions influenced the binding constants, highlighting potential implications for drug dosage and therapeutic effectiveness. 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data-work-id="436698"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/436698/Interaction_of_Bioactive_Coomassie_Brilliant_Blue_G_With_Protein_Insights_From_Spectroscopic_Methods"><img alt="Research paper thumbnail of Interaction of Bioactive Coomassie Brilliant Blue G With Protein: Insights From Spectroscopic Methods" class="work-thumbnail" src="https://attachments.academia-assets.com/51410440/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/436698/Interaction_of_Bioactive_Coomassie_Brilliant_Blue_G_With_Protein_Insights_From_Spectroscopic_Methods">Interaction of Bioactive Coomassie Brilliant Blue G With Protein: Insights From Spectroscopic Methods</a></div><div class="wp-workCard_item"><span>Scientia …</span><span>, Jan 1, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The binding of coomassie brilliant blue G (CBB) to bovine serum albumin (BSA) was investigated un...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The binding of coomassie brilliant blue G (CBB) to bovine serum albumin (BSA) was investigated under simulative physiological conditions employing different optical spectroscopic techniques viz., fluorescence emission, UV–visible absorption and FTIR. Fluorescence quenching data obtained at different temperatures suggested the presence of dynamic type of quenching mechanism. The binding constant of CBB-BSA and the number of binding sites (n) for CBB in BSA were calculated and found to be 4.20 × 104 M−1 and 0.96 respectively, at 302 K. The value of n close to unity indicated that the protein has a single class of binding sites for CBB. The thermodynamic parameters revealed that the hydrophobic forces played a major role in the interaction of CBB to BSA. The distance between the CBB and protein was calculated using the theory of Föster’s Resonance Energy Transfer (FRET). The conformational change in the secondary structure of BSA upon interaction with dye was investigated by synchronous fluorescence and FTIR techniques. Competitive binding studies were also carried out to know the location of binding of CBB on BSA.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c54f3d4818af85709beb4c424d09b607" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":51410440,"asset_id":436698,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/51410440/download_file?st=MTczNzI1ODQyOCw4LjIyMi4yMDguMTQ2&st=MTczNzI1ODQyOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="436698"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="436698"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 436698; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=436698]").text(description); $(".js-view-count[data-work-id=436698]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 436698; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='436698']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 436698, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "c54f3d4818af85709beb4c424d09b607" } } $('.js-work-strip[data-work-id=436698]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":436698,"title":"Interaction of Bioactive Coomassie Brilliant Blue G With Protein: Insights From Spectroscopic Methods","translated_title":"","metadata":{"abstract":"The binding of coomassie brilliant blue G (CBB) to bovine serum albumin (BSA) was investigated under simulative physiological conditions employing different optical spectroscopic techniques viz., fluorescence emission, UV–visible absorption and FTIR. 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Competitive binding studies were also carried out to know the location of binding of CBB on BSA.","publisher":"ncbi.nlm.nih.gov","publication_date":{"day":1,"month":1,"year":2010,"errors":{}},"publication_name":"Scientia …"},"translated_abstract":"The binding of coomassie brilliant blue G (CBB) to bovine serum albumin (BSA) was investigated under simulative physiological conditions employing different optical spectroscopic techniques viz., fluorescence emission, UV–visible absorption and FTIR. Fluorescence quenching data obtained at different temperatures suggested the presence of dynamic type of quenching mechanism. The binding constant of CBB-BSA and the number of binding sites (n) for CBB in BSA were calculated and found to be 4.20 × 104 M−1 and 0.96 respectively, at 302 K. The value of n close to unity indicated that the protein has a single class of binding sites for CBB. The thermodynamic parameters revealed that the hydrophobic forces played a major role in the interaction of CBB to BSA. The distance between the CBB and protein was calculated using the theory of Föster’s Resonance Energy Transfer (FRET). The conformational change in the secondary structure of BSA upon interaction with dye was investigated by synchronous fluorescence and FTIR techniques. Competitive binding studies were also carried out to know the location of binding of CBB on BSA.","internal_url":"https://www.academia.edu/436698/Interaction_of_Bioactive_Coomassie_Brilliant_Blue_G_With_Protein_Insights_From_Spectroscopic_Methods","translated_internal_url":"","created_at":"2011-02-09T18:19:40.940-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":327642,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":51410440,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/51410440/thumbnails/1.jpg","file_name":"Interaction_of_Bioactive_Coomassie_Brill20170118-3045-1n4om20.pdf","download_url":"https://www.academia.edu/attachments/51410440/download_file?st=MTczNzI1ODQyOCw4LjIyMi4yMDguMTQ2&st=MTczNzI1ODQyOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Interaction_of_Bioactive_Coomassie_Brill.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/51410440/Interaction_of_Bioactive_Coomassie_Brill20170118-3045-1n4om20-libre.pdf?1484754448=\u0026response-content-disposition=attachment%3B+filename%3DInteraction_of_Bioactive_Coomassie_Brill.pdf\u0026Expires=1737262028\u0026Signature=cVli80SPMwxeuJ6idEQ1lPnQO7XIKahtgnuCS~F7WjyFj9b4DB8lCxZOWCihBbqZM3c-xKVlbvOyKEnh8xXb87tgKAiFQYJMPO4EbTQL9R9jnoIHJoEt1flpdZW~PFEoUjkxBzYR0tpYC6Xvf68pN-E0QYRwgPeVMKygIh~kjWP-jkFnqOSH47kwAGdyRtYSCAvX2ypb1YEyVSPkaBowtwI7RfGsrxhAn7b0YKg7ZZY121aNJ9ndO45yvRwmOqzIuDA5TiKV1L1-6SijWwf5OwcqEjD1GCxAt74JeEHi6lHv5llbEK8sAaoeUAMdbL6BypOjUgULqBBr5g9GXZpJiQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Interaction_of_Bioactive_Coomassie_Brilliant_Blue_G_With_Protein_Insights_From_Spectroscopic_Methods","translated_slug":"","page_count":13,"language":"en","content_type":"Work","summary":"The binding of coomassie brilliant blue G (CBB) to bovine serum albumin (BSA) was investigated under simulative physiological conditions employing different optical spectroscopic techniques viz., fluorescence emission, UV–visible absorption and FTIR. Fluorescence quenching data obtained at different temperatures suggested the presence of dynamic type of quenching mechanism. The binding constant of CBB-BSA and the number of binding sites (n) for CBB in BSA were calculated and found to be 4.20 × 104 M−1 and 0.96 respectively, at 302 K. The value of n close to unity indicated that the protein has a single class of binding sites for CBB. The thermodynamic parameters revealed that the hydrophobic forces played a major role in the interaction of CBB to BSA. The distance between the CBB and protein was calculated using the theory of Föster’s Resonance Energy Transfer (FRET). The conformational change in the secondary structure of BSA upon interaction with dye was investigated by synchronous fluorescence and FTIR techniques. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="436700"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/436700/Electrochemical_Studies_and_Spectroscopic_Investigations_on_the_Interaction_of_An_Anticancer_Drug_With_DNA_and_Their_Analytical_Applications"><img alt="Research paper thumbnail of Electrochemical Studies and Spectroscopic Investigations on the Interaction of An Anticancer Drug With DNA and Their Analytical Applications" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/436700/Electrochemical_Studies_and_Spectroscopic_Investigations_on_the_Interaction_of_An_Anticancer_Drug_With_DNA_and_Their_Analytical_Applications">Electrochemical Studies and Spectroscopic Investigations on the Interaction of An Anticancer Drug With DNA and Their Analytical Applications</a></div><div class="wp-workCard_item"><span>Journal of Electroanalytical …</span><span>, Jan 1, 2009</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The electrochemical oxidation of an anticancer drug, gemcitabine hydrochloride (GMB) at glassy ca...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The electrochemical oxidation of an anticancer drug, gemcitabine hydrochloride (GMB) at glassy carbon electrode has been studied by voltammetric techniques. GMB shows one irreversible oxidation peak at 0.927 V in phosphate buffer of pH 7.4. 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