Molecular signatures of antibody responses derived from a systems biology study of five human vaccines

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new collection</label> </li> <li> <input type="radio" id="collections-action-panel-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="save_share" data-ga-action="collections" data-ga-label="collections_radio_existing"> <label for="collections-action-panel-existing">Add to an existing collection</label> </li> </ul> </div> <div class="controls-wrapper"> <div class="action-panel-control-wrap new-collections-controls"> <label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label> <input type="text" name="add-to-new-collection" id="collections-action-panel-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="save_share" data-ga-action="create_collection" data-ga-label="non_favorties_collection"> <div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div> </div> <div class="action-panel-control-wrap existing-collections-controls"> <label for="collections-action-panel-add-to-existing" class="action-panel-label"> Choose a collection: </label> <select id="collections-action-panel-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="save_share" data-ga-action="select_collection" data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"> </select> <div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br> <a href="#">Please try again</a> </div> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="save_share" data-ga-action="collections" data-ga-label="add"> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="collections" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="bibliography-action-panel" class="bibliography-action-panel action-panel in-progress-dots-panel" aria-hidden="true" data-bibliography-open-panel-enabled="false" data-bibliography-open-panel-url-hash="#open-bibliography-panel"> <div class="inner-wrap"> <h3 class="action-panel-heading"> Add to My Bibliography </h3> <form id="bibliography-action-panel-form" class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-add-to-bibliography-max-amount="100" data-add-to-bibliography-batch-size="10" data-bibliography-delegates-url="/list-bibliography-delegates/" data-add-to-bibliography-url="/add-to-bibliography/" data-get-article-ids-by-search-url="/get-article-ids-by-search/" data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/"> <input type="hidden" name="csrfmiddlewaretoken" value="qlZkX8JwdOyGt2Z07d7mGNhXprjMMnp7rKkaEevytChuxecibkoLipPDeY1WF6Yx"> <div class="action-panel-control-wrap bibliographies-controls"> <div class="choice-group"> <ul class="bibliographies-action-add radio-group-items"> <li> <input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/> <label for="my-bibliography">My Bibliography</label> </li> </ul> </div> </div> <div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your delegates due to an error<br> <a href="#">Please try again</a> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to bibliography' panel" ref="linksrc=close_bibliography_panel" aria-controls="bibliography-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="mybib" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true" data-saved-search-open-panel-enabled="false" data-saved-search-open-panel-url-hash="#open-saved-search-panel"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your saved search </h2> <form id="saved-search-action-panel-form" class="saved-search-action-panel-form action-panel-content action-form" data-create-saved-search-url="/create-saved-search/" data-try-search-terms-url="/try-search-term/" data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/"> <input type="hidden" name="csrfmiddlewaretoken" value="qlZkX8JwdOyGt2Z07d7mGNhXprjMMnp7rKkaEevytChuxecibkoLipPDeY1WF6Yx"> <div class="action-panel-control-wrap"> <label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk"> Name of saved search: </label> <input maxlength="200" type="text" name="saved-search-name" id="saved-search-name" class="saved-search-name" value="" required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="action-panel-control-wrap"> <label for="saved-search-term" class="action-panel-label required-field-asterisk"> Search terms: </label> <textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea> </div> <div class="test-search-term-wrap"> <a href="#" class="try-search-term">Test search terms</a> </div> <div class="choice-group action-panel-extra-margin-top"> <span class="action-panel-label" id="fieldset-label"> Would you like email updates of new search results? </span> <fieldset id="saved-search-alert" aria-describedby="fieldset-label"> <legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend> <ul class="radio-group-items"> <li> <input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked> <label for="saved-search-alert-yes" class="action-panel-label">Yes</label> </li> <li> <input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no"> <label for="saved-search-alert-no" class="action-panel-label">No</label> </li> </ul> </fieldset> </div> <div class="alert-schedule-wrap"> <div class="action-panel-control-wrap"> <label class="action-panel-label"> Email: </label> <span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span> </div> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="saved-search-frequency" class="action-panel-label"> Frequency: </label> <select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency"> <option value="monthly">Monthly</option> <option value="weekly">Weekly</option> <option value="daily">Daily</option> </select> </div> <div class="action-panel-control-wrap saved-search-monthly-additional"> <label for="saved-search-monthly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-monthly-on-day" class="no-border-panel-selector"> <option value="Sunday">The first Sunday</option> <option value="Monday">The first Monday</option> <option value="Tuesday">The first Tuesday</option> <option value="Wednesday">The first Wednesday</option> <option value="Thursday">The first Thursday</option> <option value="Friday">The first Friday</option> <option value="Saturday">The first Saturday</option> <option value="day">The first day</option> <option value="weekday">The first weekday</option> </select> </div> <div class="action-panel-control-wrap saved-search-weekly-additional"> <label for="saved-search-weekly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day"> <option value="Sunday">Sunday</option> <option value="Monday">Monday</option> <option value="Tuesday">Tuesday</option> <option value="Wednesday">Wednesday</option> <option value="Thursday">Thursday</option> <option value="Friday">Friday</option> <option value="Saturday">Saturday</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-report" class="action-panel-label"> Report format: </label> <select id="saved-search-report" class="no-border-panel-selector saved-search-report"> <option value="DocSum">Summary</option> <option value="DocSumText">Summary (text)</option> <option value="Abstract">Abstract</option> <option value="AbstractText">Abstract (text)</option> <option value="MEDLINE">PubMed</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-amount" class="action-panel-label"> Send at most: </label> <select id="saved-search-amount" class="no-border-panel-selector saved-search-amount"> <option value="1">1 item</option> <option value="5" selected>5 items</option> <option value="10">10 items</option> <option value="20">20 items</option> <option value="50">50 items</option> <option value="100">100 items</option> <option value="200">200 items</option> </select> </div> <div> <input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result"> <label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox"> Send even when there aren't any new results </label> </div> <div class="action-panel-control-wrap option-text-in-email-wrap"> <label for="saved-search-email-text" class="action-panel-label"> Optional text in email: </label> <textarea name="saved-search-email-text" id="saved-search-email-text" class="saved-search-email-text"></textarea> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Saving..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Save </button> <button class="action-panel-cancel" aria-label="Close 'Your saved search' panel" ref="linksrc=close_saved_search_panel" aria-controls="saved-search-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Create a file for external citation management software </h2> <form id="citation-manager-action-panel-form" class="action-panel-content action-form" action="/results-export-ids/" data-by-search-action="/results-export-search-data/" data-by-ids-action="/results-export-ids/" method="post" data-by-search-method="post" data-by-ids-method="post"> <input type="hidden" name="csrfmiddlewaretoken" value="qlZkX8JwdOyGt2Z07d7mGNhXprjMMnp7rKkaEevytChuxecibkoLipPDeY1WF6Yx"> <input name="results-format" type="hidden" value="pubmed"/> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Sending..." data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="save"> Create file </button> <button class="action-panel-cancel" aria-label="Close 'Send citations to citation manager' panel" ref="linksrc=close_citation_manager_panel" aria-controls="citation-manager-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your RSS Feed </h2> <form id="rss-action-panel-form" class="rss-action-panel-form action-panel-content action-form" data-create-rss-feed-url="/create-rss-feed-url/" data-search-form-term-value=""> <input type="hidden" name="csrfmiddlewaretoken" value="qlZkX8JwdOyGt2Z07d7mGNhXprjMMnp7rKkaEevytChuxecibkoLipPDeY1WF6Yx"> <div class="action-panel-control-wrap"> <label for="rss-name" class="action-panel-label required-field-asterisk"> Name of RSS Feed: </label> <input maxlength="200" placeholder="Name" type="text" name="rss-name" id="rss-name" class="rss-name" value='' required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="rss-limit-wrap"> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="rss-limit" class="action-panel-label"> Number of items displayed: </label> <select id="rss-limit" class="no-border-panel-selector rss-limit"> <option value="5">5</option> <option value="10">10</option> <option value="15" selected="selected">15</option> <option value="20">20</option> <option value="50">50</option> <option value="100">100</option> </select> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Creating..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Create RSS </button> <button class="action-panel-cancel" aria-label="Close 'Your RSS' panel" ref="linksrc=close_rss_panel" aria-controls="rss-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> <div class="action-panel-control-wrap rss-link-copy-wrap"> <label for="rss-link" class="usa-sr-only">RSS Link</label> <input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link"> <button type="button" disabled class="rss-link-copy-button disabled" data-ga-category="save_share" data-ga-action="rss" data-ga-label="copy"> Copy </button> </div> </form> </div> </div> </div> </div> <div class="article-page" id="article-page" data-article-pmid="24336226"> <aside class="page-sidebar"> <div class="inner-wrap"> <div class="full-text-links"> <div class="full-view"> <h3 class="title"> Full text links </h3> <div class="full-text-links-list"> <a class="link-item dialog-focus" 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required-field-asterisk"> Name your collection: </label><input type="text" name="add-to-new-collection" id="collections-action-dialog-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="collections_button" data-ga-action="create_collection" data-ga-label="non_favorties_collection"><div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div></div><div class="action-panel-control-wrap existing-collections-controls"><label for="collections-action-dialog-add-to-existing" class="action-panel-label"> Choose a collection: </label><select id="collections-action-dialog-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="collections_button" data-ga-action="select_collection" data-ga-label="($('.collections-action-add-to-existing').val() === 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class="content"><ul class="journal-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Nat+Immunol%22%5Bjour%5D&sort=date&sort_order=desc" data-href="/?term=%22Nat+Immunol%22%5Bjour%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_journal_name_link&journal_abbrev=Nat Immunol" data-ga-category="search" data-ga-action="journal_link" data-ga-label="Nat Immunol"> Search in PubMed </a></li><li><a class="search-in-nlm-catalog-link dropdown-block-link" ref ="linksrc=search_in_nlm_catalog_link" href="https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Nat+Immunol%22%5BTitle+Abbreviation%5D" data-ga-category="search_catalog" data-ga-action="journal_link" data-ga-label="Nat Immunol"> Search in NLM Catalog </a></li><li><a class="add-to-search-link dropdown-block-link" ref ="linksrc=add_to_search_link" role="button" data-search-term='"Nat Immunol"[jour]' data-ga-category="search" data-ga-action="add_to_search" data-ga-label='"Nat Immunol"[jour]' href="#"> Add to Search </a></li></ul></div></div></div><span class="period">. </span><span class="cit">2014 Feb;15(2):195-204.</span> </div> <span class="citation-doi"> doi: 10.1038/ni.2789. </span> <span class="secondary-date"> Epub 2013 Dec 15. </span> </div> <h1 class="heading-title"> Molecular signatures of antibody responses derived from a systems biology study of five human vaccines </h1> <div class="inline-authors"> <div class="authors"> <div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Li+S&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Shuzhao Li">Shuzhao Li</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. [3]." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Rouphael+N&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Nadine Rouphael">Nadine Rouphael</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] The Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Emory University, Decatur, Georgia, USA. [3]." href="#full-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Duraisingham+S&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Sai Duraisingham">Sai Duraisingham</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. [3]." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Romero-Steiner+S&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Sandra Romero-Steiner">Sandra Romero-Steiner</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA." href="#full-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Presnell+S&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Scott Presnell">Scott Presnell</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="1] Benaroya Research Institute, Seattle, Washington, USA. [2] Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, USA." href="#full-view-affiliation-4" ref="linksrc=author_aff"> 4 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Davis+C&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Carl Davis">Carl Davis</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA." href="#full-view-affiliation-5" ref="linksrc=author_aff"> 5 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Schmidt+DS&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Daniel S Schmidt">Daniel S Schmidt</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA." href="#full-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Johnson+SE&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Scott E Johnson">Scott E Johnson</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA." href="#full-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Milton+A&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Andrea Milton">Andrea Milton</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA." href="#full-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Rajam+G&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Gowrisankar Rajam">Gowrisankar Rajam</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA." href="#full-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kasturi+S&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Sudhir Kasturi">Sudhir Kasturi</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA." href="#full-view-affiliation-6" ref="linksrc=author_aff"> 6 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Carlone+GM&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="George M Carlone">George M Carlone</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA." href="#full-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Quinn+C&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Charlie Quinn">Charlie Quinn</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="1] Benaroya Research Institute, Seattle, Washington, USA. [2] Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, USA." href="#full-view-affiliation-4" ref="linksrc=author_aff"> 4 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Chaussabel+D&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Damien Chaussabel">Damien Chaussabel</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="1] Benaroya Research Institute, Seattle, Washington, USA. [2] Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, USA." href="#full-view-affiliation-4" ref="linksrc=author_aff"> 4 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Palucka+AK&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="A Karolina Palucka">A Karolina Palucka</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, USA." href="#full-view-affiliation-7" ref="linksrc=author_aff"> 7 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Mulligan+MJ&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Mark J Mulligan">Mark J Mulligan</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] The Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Emory University, Decatur, Georgia, USA. [3] Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA." href="#full-view-affiliation-8" ref="linksrc=author_aff"> 8 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Ahmed+R&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Rafi Ahmed">Rafi Ahmed</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA." href="#full-view-affiliation-9" ref="linksrc=author_aff"> 9 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Stephens+DS&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="David S Stephens">David S Stephens</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA." href="#full-view-affiliation-5" ref="linksrc=author_aff"> 5 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Nakaya+HI&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Helder I Nakaya">Helder I Nakaya</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. [3] Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA." href="#full-view-affiliation-10" ref="linksrc=author_aff"> 10 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Pulendran+B&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Bali Pulendran">Bali Pulendran</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. [3] Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA." href="#full-view-affiliation-10" ref="linksrc=author_aff"> 10 </a></sup></span> </div> </div> </div> <div class="short-article-details"> Affiliations <button class="more-details" id="toggle-authors" data-alt-text="Collapse" aria-controls="expanded-authors" aria-expanded="false" data-pinger-ignore data-fetch-url="/24336226/long-authors/" data-id-prefix=""> <span class="title"> Expand </span> </button> </div> <div class="extended-article-details" id="expanded-authors" aria-hidden="true"> <div class="expanded-authors" id="full-view-expanded-authors"> <div class="affiliations"> <h3 class="title"> Affiliations </h3> <ul class="item-list"> <li data-affiliation-id="full-view-affiliation-1" id="full-view-affiliation-1" ><sup class="key">1</sup> 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. [3].</li> <li data-affiliation-id="full-view-affiliation-2" id="full-view-affiliation-2" ><sup class="key">2</sup> 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] The Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Emory University, Decatur, Georgia, USA. [3].</li> <li data-affiliation-id="full-view-affiliation-3" id="full-view-affiliation-3" ><sup class="key">3</sup> Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.</li> <li data-affiliation-id="full-view-affiliation-4" id="full-view-affiliation-4" ><sup class="key">4</sup> 1] Benaroya Research Institute, Seattle, Washington, USA. [2] Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, USA.</li> <li data-affiliation-id="full-view-affiliation-5" id="full-view-affiliation-5" ><sup class="key">5</sup> 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.</li> <li data-affiliation-id="full-view-affiliation-6" id="full-view-affiliation-6" ><sup class="key">6</sup> 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.</li> <li data-affiliation-id="full-view-affiliation-7" id="full-view-affiliation-7" ><sup class="key">7</sup> Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, USA.</li> <li data-affiliation-id="full-view-affiliation-8" id="full-view-affiliation-8" ><sup class="key">8</sup> 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] The Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Emory University, Decatur, Georgia, USA. [3] Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.</li> <li data-affiliation-id="full-view-affiliation-9" id="full-view-affiliation-9" ><sup class="key">9</sup> 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA.</li> <li data-affiliation-id="full-view-affiliation-10" id="full-view-affiliation-10" ><sup class="key">10</sup> 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. [3] Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA.</li> </ul> </div> </div> </div> <ul class="identifiers" id="full-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">24336226</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=PMC3946932&id_type=PMC" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC3946932/" data-ga-category="full_text" data-ga-action="PMCID" > PMC3946932 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1038/ni.2789&id_type=DOI" href="https://doi.org/10.1038/ni.2789" data-ga-category="full_text" data-ga-action="DOI" > 10.1038/ni.2789 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> <div class="short-view" id="short-view-heading"> <h1 class="heading-title"> Molecular signatures of antibody responses derived from a systems biology study of five human vaccines </h1> <div class="short-citation"> <span class="authors-list"> <span class="authors-list-item "><span class="full-name">Shuzhao Li</span><span class="citation-separator"> et al.</span></span> </span> <span class="citation-journal"> Nat Immunol<span class="citation-separator">.</span> </span> <span class="date"> <span class="citation-year">2014 Feb</span><span class="citation-separator">.</span> </span> </div> <div class="more-article-details-section with-display-settings"> <button class="more-article-details" id="toggle-article-details" data-alt-text="Hide details" ref="linksrc=toggle_article_details" aria-controls="full-article-details" aria-expanded="false" data-fetch-url="/24336226/long-authors/" data-id-prefix=""> <span class="title">Show 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id="short-view-journal-trigger" class="journal-actions-trigger trigger" ref="linksrc=journal_actions_btn" title="Nature immunology" tabindex="0" aria-controls="short-view-journal" aria-expanded="false" aria-label="Toggle dropdown menu for journal Nature immunology" data-pinger-ignore> Nat Immunol </button><div id="short-view-journal" class="journal-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for journal Nature immunology"><div class="title">Actions</div><div class="content"><ul class="journal-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Nat+Immunol%22%5Bjour%5D&sort=date&sort_order=desc" data-href="/?term=%22Nat+Immunol%22%5Bjour%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_journal_name_link&journal_abbrev=Nat Immunol" data-ga-category="search" data-ga-action="journal_link" data-ga-label="Nat Immunol"> Search in PubMed </a></li><li><a class="search-in-nlm-catalog-link dropdown-block-link" ref ="linksrc=search_in_nlm_catalog_link" href="https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Nat+Immunol%22%5BTitle+Abbreviation%5D" data-ga-category="search_catalog" data-ga-action="journal_link" data-ga-label="Nat Immunol"> Search in NLM Catalog </a></li><li><a class="add-to-search-link dropdown-block-link" ref ="linksrc=add_to_search_link" role="button" data-search-term='"Nat Immunol"[jour]' data-ga-category="search" data-ga-action="add_to_search" data-ga-label='"Nat Immunol"[jour]' href="#"> Add to Search </a></li></ul></div></div></div><span class="period">. </span><span class="cit">2014 Feb;15(2):195-204.</span> </div> <span class="citation-doi"> doi: 10.1038/ni.2789. </span> <span class="secondary-date"> Epub 2013 Dec 15. </span> </div> <div class="expanded-authors" id="short-view-expanded-authors"> <div class="authors"> <h3 class="title"> Authors </h3> <div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Li+S&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Shuzhao Li">Shuzhao Li</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. [3]." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Rouphael+N&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Nadine Rouphael">Nadine Rouphael</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] The Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Emory University, Decatur, Georgia, USA. [3]." href="#short-view-affiliation-2" ref="linksrc=author_aff"> 2 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Duraisingham+S&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Sai Duraisingham">Sai Duraisingham</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. [3]." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Romero-Steiner+S&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Sandra Romero-Steiner">Sandra Romero-Steiner</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA." href="#short-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Presnell+S&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Scott Presnell">Scott Presnell</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="1] Benaroya Research Institute, Seattle, Washington, USA. [2] Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, USA." href="#short-view-affiliation-4" ref="linksrc=author_aff"> 4 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Davis+C&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Carl Davis">Carl Davis</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA." href="#short-view-affiliation-5" ref="linksrc=author_aff"> 5 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Schmidt+DS&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Daniel S Schmidt">Daniel S Schmidt</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA." href="#short-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Johnson+SE&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Scott E Johnson">Scott E Johnson</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA." href="#short-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Milton+A&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Andrea Milton">Andrea Milton</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA." href="#short-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Rajam+G&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Gowrisankar Rajam">Gowrisankar Rajam</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA." href="#short-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Kasturi+S&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Sudhir Kasturi">Sudhir Kasturi</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA." href="#short-view-affiliation-6" ref="linksrc=author_aff"> 6 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Carlone+GM&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="George M Carlone">George M Carlone</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA." href="#short-view-affiliation-3" ref="linksrc=author_aff"> 3 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Quinn+C&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Charlie Quinn">Charlie Quinn</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="1] Benaroya Research Institute, Seattle, Washington, USA. [2] Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, USA." href="#short-view-affiliation-4" ref="linksrc=author_aff"> 4 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Chaussabel+D&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Damien Chaussabel">Damien Chaussabel</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="1] Benaroya Research Institute, Seattle, Washington, USA. [2] Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, USA." href="#short-view-affiliation-4" ref="linksrc=author_aff"> 4 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Palucka+AK&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="A Karolina Palucka">A Karolina Palucka</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, USA." href="#short-view-affiliation-7" ref="linksrc=author_aff"> 7 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Mulligan+MJ&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Mark J Mulligan">Mark J Mulligan</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] The Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Emory University, Decatur, Georgia, USA. [3] Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA." href="#short-view-affiliation-8" ref="linksrc=author_aff"> 8 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Ahmed+R&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Rafi Ahmed">Rafi Ahmed</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA." href="#short-view-affiliation-9" ref="linksrc=author_aff"> 9 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Stephens+DS&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="David S Stephens">David S Stephens</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA." href="#short-view-affiliation-5" ref="linksrc=author_aff"> 5 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Nakaya+HI&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Helder I Nakaya">Helder I Nakaya</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. [3] Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA." href="#short-view-affiliation-10" ref="linksrc=author_aff"> 10 </a></sup><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Pulendran+B&cauthor_id=24336226" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Bali Pulendran">Bali Pulendran</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. [3] Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA." href="#short-view-affiliation-10" ref="linksrc=author_aff"> 10 </a></sup></span> </div> </div> <div class="affiliations"> <h3 class="title"> Affiliations </h3> <ul class="item-list"> <li data-affiliation-id="short-view-affiliation-1" id="short-view-affiliation-1" ><sup class="key">1</sup> 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. [3].</li> <li data-affiliation-id="short-view-affiliation-2" id="short-view-affiliation-2" ><sup class="key">2</sup> 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] The Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Emory University, Decatur, Georgia, USA. [3].</li> <li data-affiliation-id="short-view-affiliation-3" id="short-view-affiliation-3" ><sup class="key">3</sup> Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center of Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.</li> <li data-affiliation-id="short-view-affiliation-4" id="short-view-affiliation-4" ><sup class="key">4</sup> 1] Benaroya Research Institute, Seattle, Washington, USA. [2] Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, USA.</li> <li data-affiliation-id="short-view-affiliation-5" id="short-view-affiliation-5" ><sup class="key">5</sup> 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.</li> <li data-affiliation-id="short-view-affiliation-6" id="short-view-affiliation-6" ><sup class="key">6</sup> 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.</li> <li data-affiliation-id="short-view-affiliation-7" id="short-view-affiliation-7" ><sup class="key">7</sup> Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, USA.</li> <li data-affiliation-id="short-view-affiliation-8" id="short-view-affiliation-8" ><sup class="key">8</sup> 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] The Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Emory University, Decatur, Georgia, USA. [3] Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia, USA.</li> <li data-affiliation-id="short-view-affiliation-9" id="short-view-affiliation-9" ><sup class="key">9</sup> 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA.</li> <li data-affiliation-id="short-view-affiliation-10" id="short-view-affiliation-10" ><sup class="key">10</sup> 1] Emory Vaccine Center, Emory University, Atlanta, Georgia, USA. [2] Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA. [3] Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA.</li> </ul> </div> </div> <ul class="identifiers" id="short-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">24336226</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=PMC3946932&id_type=PMC" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC3946932/" data-ga-category="full_text" data-ga-action="PMCID" > PMC3946932 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1038/ni.2789&id_type=DOI" href="https://doi.org/10.1038/ni.2789" data-ga-category="full_text" data-ga-action="DOI" > 10.1038/ni.2789 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> </div> </header> <div class="actions-buttons inline"><div class="inner-wrap"><button class="full-text-links-button full-text-links-dialog-trigger" title="Open dialog with full text links" ref="linksrc=full_text_links"> Full text links </button><button class="citation-button citation-dialog-trigger" aria-label="Open dialog with citation text in different styles" data-ga-category="save_share" data-ga-action="cite" data-ga-label="open" data-all-citations-url="/24336226/citations/" data-citation-style="nlm" data-pubmed-format-link="/24336226/export/"><span class="button-label">Cite</span></button><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"><button class="trigger usa-button" title="Change format" data-ga-category="display_options" data-ga-action="display_options_dialog"><span class="button-label">Display options</span></button><div class="dropdown" hidden><div class="title"> Display options </div><div class="content"><div class="format-container"><span class="option-label"> Format </span><select name="format" data-initial-value="abstract" aria-label="Display format" id="inline-actions-display-format"><option value="abstract">Abstract</option><option value="pubmed">PubMed</option><option value="pmid">PMID</option></select></div></div></div></div></div></div> <div class="abstract" id="abstract"> <h2 class="title"> Abstract </h2> <div class="abstract-content selected" id="eng-abstract"> <p> Many vaccines induce protective immunity via antibodies. Systems biology approaches have been used to determine signatures that can be used to predict vaccine-induced immunity in humans, but whether there is a 'universal signature' that can be used to predict antibody responses to any vaccine is unknown. Here we did systems analyses of immune responses to the polysaccharide and conjugate vaccines against meningococcus in healthy adults, in the broader context of published studies of vaccines against yellow fever virus and influenza virus. To achieve this, we did a large-scale network integration of publicly available human blood transcriptomes and systems-scale databases in specific biological contexts and deduced a set of transcription modules in blood. Those modules revealed distinct transcriptional signatures of antibody responses to different classes of vaccines, which provided key insights into primary viral, protein recall and anti-polysaccharide responses. Our results elucidate the early transcriptional programs that orchestrate vaccine immunity in humans and demonstrate the power of integrative network modeling. </p> </div> </div> <p class="disclaimer" id="disclaimer"> <a href="/disclaimer/" target="_blank" data-ga-category="literature_resources" data-ga-action="disclaimer_link" data-ga-label="under_abstract">PubMed Disclaimer</a> </p> <div class="conflict-of-interest" id="conflict-of-interest"> <h2 class="title"> Conflict of interest statement </h2> <div class="statement"> <p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one"><bold>Competing financial interests</bold></p> <p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one">The authors declare no competing financial interests.</p> </div> </div> <div class="figures" id="figures"> <h2 class="title"> Figures </h2> <div class="figures-list" id="slides-container" itemscope itemtype="http://schema.org/ImageGallery"> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="0" data-label-slug="figure-1"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4583/3946932/034852a915a8/nihms540680f1.jpg" itemprop="contentUrl" aria-describedby="figure-caption-0" role="button" data-image-width="632" data-image-height="389" data-image-alt="Figure 1" data-pmc-id="PMC3946932" data-figure-id="F1"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-0" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4583/3946932/c14d988cd54a/nihms540680f1.gif" alt="Figure 1" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="632"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="389"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 1 </p> </strong> <div class="figure-caption-contents"><p> Antibody responses of meningococcal vaccinees.… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 1 </p> </strong> <div class="figure-caption-contents"><p> Antibody responses of meningococcal vaccinees. Serogroups A and C were measured for total… </p></div> </div> <figcaption id="figure-caption-0" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 1 </strong> <div class="figure-caption-contents">Antibody responses of meningococcal vaccinees. Serogroups A and C were measured for total IgG (<b>a</b>), IgG1 and IgG2 (<b>b</b>), IgM (<b>c</b>) and SBA titers (<b>d</b>). (<b>e</b>) A strong IgG response against diphtheria toxoid was detected in MCV4 vaccinees. (<b>f</b>) Antibody secreting cells (ASCs, selected as CD3<sup>−</sup> CD20<sup>−</sup> CD38<sup>hi</sup> CD27<sup>hi</sup> CD19<sup>+</sup> cells) and (<b>g</b>) the number of ASCs at day 7 correlated with diphtheria toxoid-specific serum IgG at day 7. * <i>p</i><0.05, ** <i>p</i><0.01, *** <i>p</i><0.001; unpaired <i>t</i>-test was used for comparisons between vaccine groups, paired <i>t</i>-test was used for comparisons to baseline within a group, Pearson’s correlation was used in (<b>g</b>). All plots show mean values (<i>n</i>=13 for MPSV4 and <i>n</i>=17 for MCV4) from one experiment, error bars as s.e.m.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="1" data-label-slug="figure-2"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4583/3946932/ae2e1be8ff1c/nihms540680f2.jpg" itemprop="contentUrl" aria-describedby="figure-caption-1" role="button" data-image-width="600" data-image-height="483" data-image-alt="Figure 2" data-pmc-id="PMC3946932" data-figure-id="F2"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-1" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4583/3946932/97f7a377f79e/nihms540680f2.gif" alt="Figure 2" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="600"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="483"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 2 </p> </strong> <div class="figure-caption-contents"><p> Analysis of blood transcriptomic data… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 2 </p> </strong> <div class="figure-caption-contents"><p> Analysis of blood transcriptomic data from five human vaccines. ( <b> a </b> ) Differential… </p></div> </div> <figcaption id="figure-caption-1" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 2 </strong> <div class="figure-caption-contents">Analysis of blood transcriptomic data from five human vaccines. (<b>a</b>) Differential expression analysis was performed using paired t-test for each vaccine and each time point (day 3 or day 7 compared to baseline). The red dots in volcano plots show differentially expressed genes (DEGs, <i>p</i> < 0.001), with the numbers of DEGs. (<b>b</b>) A work flow to compare the transcriptomic signatures of five human vaccines.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="2" data-label-slug="figure-3"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4583/3946932/d2f4fb832b0f/nihms540680f3.jpg" itemprop="contentUrl" aria-describedby="figure-caption-2" role="button" data-image-width="790" data-image-height="835" data-image-alt="Figure 3" data-pmc-id="PMC3946932" data-figure-id="F3"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-2" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4583/3946932/761a30ecf0b4/nihms540680f3.gif" alt="Figure 3" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="790"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="835"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 3 </p> </strong> <div class="figure-caption-contents"><p> Differential expression analysis of five… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 3 </p> </strong> <div class="figure-caption-contents"><p> Differential expression analysis of five vaccines. ( <b> a </b> ) Online interactive figure showing… </p></div> </div> <figcaption id="figure-caption-2" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 3 </strong> <div class="figure-caption-contents">Differential expression analysis of five vaccines. (<b>a</b>) Online interactive figure showing DEGs shared between vaccine studies (online data portal <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.immuneprofiling.org/papers/meni/">http://www.immuneprofiling.org/papers/meni/</ext-link>, snapshot of Interactive Fig. 1). Links are shown in blue. When a given vaccine is selected, links are shown in green. (<b>b</b>) Selected DEGs involved in B cell development and innate immunity. (<b>c</b>) The DEGs plus “linker” genes identified by our interactome/bibliome integrative approach and shared by four or more vaccines are enriched with a number of gene ontology categories related to immune system. The genes found in ‘immune system development’ are shown in Supplementary Fig. 4f.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="3" data-label-slug="figure-4"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4583/3946932/eb31d26892d8/nihms540680f4.jpg" itemprop="contentUrl" aria-describedby="figure-caption-3" role="button" data-image-width="800" data-image-height="898" data-image-alt="Figure 4" data-pmc-id="PMC3946932" data-figure-id="F4"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-3" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4583/3946932/9732dd1849f5/nihms540680f4.gif" alt="Figure 4" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="800"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="898"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 4 </p> </strong> <div class="figure-caption-contents"><p> Blood transcription modules provide a… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 4 </p> </strong> <div class="figure-caption-contents"><p> Blood transcription modules provide a sensitive and robust statistical framework. ( <b> a </b> )… </p></div> </div> <figcaption id="figure-caption-3" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 4 </strong> <div class="figure-caption-contents">Blood transcription modules provide a sensitive and robust statistical framework. (<b>a</b>) Construction of blood transcription modules (BTM) through large scale data integration. Full details are given in the Supplementary Note. (<b>b</b>) BTMs show superior sensitivity (assessed by t-score) compared to canonical pathways in class comparison. MCV4 transcriptomic data at D3/0 are used as example. Additional examples can be found in Supplementary Fig. 9. (<b>c</b>) Assessing the statistical significance of BTM correlation to antibody data. Each module is collapsed to a single activity score (mean value of all member genes), and Pearson correlation to antibody data is calculated across all subjects (red bars). The gray area is the distribution of random data generated by permutations of module gene memberships and sample labels. Data shown is the D3/0 MCV4 transcriptome data. <b>(d</b>) BTM module M156.1 consists of mostly immunoglobulin genes. Each edge represents a coexpression relationship learned from public data. <i>CD27</i>, <i>TNFRSF17</i> and <i>MZB1</i> are known B cell regulators, and <i>POU2AF1</i> is a regulator of <i>TNFRSF17</i>. (<b>e</b>) Correlation of module M156.1 activity and later antibody response (MCV4-DT).</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="4" data-label-slug="figure-5"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4583/3946932/666a05d58bc4/nihms540680f5.jpg" itemprop="contentUrl" aria-describedby="figure-caption-4" role="button" data-image-width="593" data-image-height="714" data-image-alt="Figure 5" data-pmc-id="PMC3946932" data-figure-id="F5"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-4" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4583/3946932/672fb731513f/nihms540680f5.gif" alt="Figure 5" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="593"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="714"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 5 </p> </strong> <div class="figure-caption-contents"><p> BTM analysis reveals distinct mechanisms… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 5 </p> </strong> <div class="figure-caption-contents"><p> BTM analysis reveals distinct mechanisms of antibody response. ( <b> a </b> ) Each vaccine… </p></div> </div> <figcaption id="figure-caption-4" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 5 </strong> <div class="figure-caption-contents">BTM analysis reveals distinct mechanisms of antibody response. (<b>a</b>) Each vaccine data set is shown as one of six segments on the circular plot. In each segment, the inner circular bands show an ordered list of all BTM modules, layered by histograms of modules significantly correlated to the antibody response, red for positive correlation and blue for negative correlation. Significant modules that are common between vaccines (as in Supplementary Fig. 12b, c, d) are linked by a color curve in the center (gray links for modules omitted in Supplementary Figure 11). An interactive version of this figure is available (online data portal, Interactive Figure 2). (<b>b</b>) Illustration of module activity. A filled unit in the center grid indicates the membership of the gene (top axis) in the corresponding module (left axis). The heat map on the right shows the Pearson correlation between module activity and antibody response in each study. The bottom heat map shows correlation between module member genes and the antibody response.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="5" data-label-slug="figure-6"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4583/3946932/6ac283a8402d/nihms540680f6.jpg" itemprop="contentUrl" aria-describedby="figure-caption-5" role="button" data-image-width="764" data-image-height="519" data-image-alt="Figure 6" data-pmc-id="PMC3946932" data-figure-id="F6"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-5" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4583/3946932/7eaac480a077/nihms540680f6.gif" alt="Figure 6" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="764"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="519"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 6 </p> </strong> <div class="figure-caption-contents"><p> The meningococcal polysaccharide vaccine activates… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 6 </p> </strong> <div class="figure-caption-contents"><p> The meningococcal polysaccharide vaccine activates myeloid dendritic cells. ( <b> a </b> ) Induction of… </p></div> </div> <figcaption id="figure-caption-5" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 6 </strong> <div class="figure-caption-contents">The meningococcal polysaccharide vaccine activates myeloid dendritic cells. (<b>a</b>) Induction of cytokines by MPSV4 from human myeloid DC (4 independent replicates) and monocyte derived DC (6 independent replicates). Mean values of independent replicates are shown, error bars as s.e.m. Secreted IL-6 protein levels are shown but the same result was observed for TNF and IL-12p40 levels. (<b>b</b>) Mouse knockout DCs show that the MPSV4 stimulation is dependent on <i>Myd88</i>, <i>Trif</i>, <i>Tlr4</i> and <i>Asc in vitro</i>. CD11c<sup>+</sup> DCs were isolated by MACS from spleens of C57BL/6 mice (WT) or various knock-out mice and stimulated for 24 h; *p<0.05, ***p<0.0001, unpaired <i>t</i>-test was used to compare WT vs. KO. Four independent replicates were performed for <i>Myd88</i>, <i>Trif</i> and <i>Tlr4</i> knockouts, six for <i>Asc</i> knockouts. One representative experiment is shown, with mean values and s.e.m. from technical replicates.</div> </figcaption> </figure> </div>  <div class="pswp figures-dialog" id="figures-dialog" tabindex="-1" role="dialog" aria-hidden="true" data-image-gallery-uid="article-figures" aria-label="Figures Dialog">  <div class="pswp__bg"></div>  <div class="pswp__scroll-wrap">  <div class="pswp__container"> <div class="pswp__item"></div> <div class="pswp__item"></div> <div class="pswp__item"></div> </div>  <div class="pswp__ui pswp__ui--hidden"> <div class="pswp__top-bar">  <div class="pswp__counter"></div> <button class="pswp__button pswp__button--close" title="Close (Esc)"></button> <button class="pswp__button pswp__button--share" title="Share"></button> <button class="pswp__button pswp__button--fs" title="Toggle fullscreen"></button> <button class="pswp__button pswp__button--zoom" title="Zoom in/out"></button>   <div class="pswp__preloader"> <div class="pswp__preloader__icn"> <div 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href="https://www.ncbi.nlm.nih.gov/mesh?term=Humans" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Humans"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Humans"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Humans"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Immunity, Active" tabindex="0" aria-controls="keyword-actions-mesh-terms-6" aria-expanded="false" data-pinger-ignore> Immunity, Active </button><div id="keyword-actions-mesh-terms-6" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Immunity, Active"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Immunity%2C+Active%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Immunity%2C+Active%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Immunity, Active"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Immunity, Active"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Immunity%2C+Active" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Immunity, Active"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Immunity, Active"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Immunity, Active"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Immunoglobulins / blood" tabindex="0" aria-controls="keyword-actions-mesh-terms-7" aria-expanded="false" data-pinger-ignore> Immunoglobulins / blood </button><div id="keyword-actions-mesh-terms-7" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Immunoglobulins / blood"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Immunoglobulins%2Fblood%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Immunoglobulins%2Fblood%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Immunoglobulins/blood"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Immunoglobulins / blood"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Immunoglobulins" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Immunoglobulins / blood"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Immunoglobulins/blood"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Immunoglobulins/blood"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Influenza Vaccines / immunology" tabindex="0" aria-controls="keyword-actions-mesh-terms-8" aria-expanded="false" data-pinger-ignore> Influenza Vaccines / immunology </button><div id="keyword-actions-mesh-terms-8" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Influenza Vaccines / immunology"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Influenza+Vaccines%2Fimmunology%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Influenza+Vaccines%2Fimmunology%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Influenza Vaccines/immunology"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Influenza Vaccines / immunology"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Influenza+Vaccines" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Influenza Vaccines / immunology"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Influenza Vaccines/immunology"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Influenza Vaccines/immunology"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Male" tabindex="0" aria-controls="keyword-actions-mesh-terms-9" aria-expanded="false" data-pinger-ignore> Male </button><div id="keyword-actions-mesh-terms-9" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Male"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Male%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Male%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Male"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Male"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Male" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Male"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Male"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Male"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Meningococcal Infections / immunology" tabindex="0" aria-controls="keyword-actions-mesh-terms-10" aria-expanded="false" data-pinger-ignore> Meningococcal Infections / immunology </button><div id="keyword-actions-mesh-terms-10" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Meningococcal Infections / immunology"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Meningococcal+Infections%2Fimmunology%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Meningococcal+Infections%2Fimmunology%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Meningococcal Infections/immunology"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Meningococcal Infections / immunology"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Meningococcal+Infections" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Meningococcal Infections / immunology"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Meningococcal Infections/immunology"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Meningococcal Infections/immunology"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Meningococcal Infections / prevention & control*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-11" aria-expanded="false" data-pinger-ignore> Meningococcal Infections / prevention & control* </button><div id="keyword-actions-mesh-terms-major-11" 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data-ga-label="Meningococcal Infections / prevention & control*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Meningococcal Infections/prevention and control"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Meningococcal Infections/prevention and control"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Meningococcal Vaccines / immunology*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-12" aria-expanded="false" data-pinger-ignore> Meningococcal Vaccines / immunology* </button><div id="keyword-actions-mesh-terms-major-12" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Meningococcal Vaccines / immunology*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Meningococcal+Vaccines%2Fimmunology%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Meningococcal+Vaccines%2Fimmunology%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Meningococcal Vaccines/immunology"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Meningococcal Vaccines / immunology*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Meningococcal+Vaccines" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Meningococcal Vaccines / immunology*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Meningococcal Vaccines/immunology"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Meningococcal Vaccines/immunology"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Middle Aged" tabindex="0" aria-controls="keyword-actions-mesh-terms-13" aria-expanded="false" data-pinger-ignore> Middle Aged </button><div id="keyword-actions-mesh-terms-13" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Middle Aged"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Middle+Aged%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Middle+Aged%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Middle Aged"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Middle Aged"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Middle+Aged" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Middle Aged"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Middle Aged"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Middle Aged"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Neisseria meningitidis / immunology*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-14" aria-expanded="false" data-pinger-ignore> Neisseria meningitidis / immunology* </button><div id="keyword-actions-mesh-terms-major-14" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Neisseria meningitidis / immunology*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Neisseria+meningitidis%2Fimmunology%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Neisseria+meningitidis%2Fimmunology%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Neisseria meningitidis/immunology"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Neisseria meningitidis / immunology*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Neisseria+meningitidis" 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class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Systems+Biology%2Fmethods%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Systems+Biology%2Fmethods%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Systems Biology/methods"[MAJR]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Systems Biology / methods*"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Systems+Biology" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Systems Biology / methods*"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Systems Biology/methods"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Systems Biology/methods"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Transcriptome" tabindex="0" aria-controls="keyword-actions-mesh-terms-16" aria-expanded="false" data-pinger-ignore> Transcriptome </button><div id="keyword-actions-mesh-terms-16" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Transcriptome"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Transcriptome%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Transcriptome%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Transcriptome"[MeSH]" data-ga-category="search" 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id="keyword-actions-mesh-terms-17" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Vaccines, Conjugate / immunology"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Vaccines%2C+Conjugate%2Fimmunology%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Vaccines%2C+Conjugate%2Fimmunology%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Vaccines, Conjugate/immunology"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Vaccines, Conjugate / immunology"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Vaccines%2C+Conjugate" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Vaccines, Conjugate / immunology"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Vaccines, Conjugate/immunology"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Vaccines, Conjugate/immunology"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Yellow Fever Vaccine / immunology" tabindex="0" aria-controls="keyword-actions-mesh-terms-18" aria-expanded="false" data-pinger-ignore> Yellow Fever Vaccine / immunology </button><div id="keyword-actions-mesh-terms-18" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Yellow Fever Vaccine / immunology"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Yellow+Fever+Vaccine%2Fimmunology%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Yellow+Fever+Vaccine%2Fimmunology%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Yellow Fever Vaccine/immunology"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Yellow Fever Vaccine / immunology"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Yellow+Fever+Vaccine" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Yellow Fever Vaccine / immunology"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Yellow Fever Vaccine/immunology"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Yellow Fever Vaccine/immunology"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Young Adult" tabindex="0" aria-controls="keyword-actions-mesh-terms-19" aria-expanded="false" data-pinger-ignore> Young Adult </button><div id="keyword-actions-mesh-terms-19" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Young Adult"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Young+Adult%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Young+Adult%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Young Adult"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Young Adult"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Young+Adult" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Young Adult"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Young Adult"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Young Adult"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li></ul> </div> <div id="substances" class="substances keywords-section"> <h2 class="title"> Substances </h2> <ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Immunoglobulins" tabindex="0" aria-controls="keyword-actions-substances-0" aria-expanded="false" data-pinger-ignore> Immunoglobulins </button><div id="keyword-actions-substances-0" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Immunoglobulins"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Immunoglobulins%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Immunoglobulins%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Immunoglobulins"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Immunoglobulins"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Immunoglobulins%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="Immunoglobulins"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Immunoglobulins"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Immunoglobulins"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Influenza Vaccines" tabindex="0" aria-controls="keyword-actions-substances-1" aria-expanded="false" data-pinger-ignore> Influenza Vaccines </button><div id="keyword-actions-substances-1" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Influenza Vaccines"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Influenza+Vaccines%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Influenza+Vaccines%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Influenza Vaccines"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Influenza Vaccines"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Influenza+Vaccines%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="Influenza Vaccines"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Influenza Vaccines"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Influenza Vaccines"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Meningococcal Vaccines" tabindex="0" aria-controls="keyword-actions-substances-2" aria-expanded="false" data-pinger-ignore> Meningococcal Vaccines </button><div id="keyword-actions-substances-2" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Meningococcal Vaccines"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Meningococcal+Vaccines%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Meningococcal+Vaccines%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Meningococcal Vaccines"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Meningococcal Vaccines"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Meningococcal+Vaccines%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="Meningococcal Vaccines"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Meningococcal Vaccines"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Meningococcal Vaccines"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Vaccines, Conjugate" tabindex="0" aria-controls="keyword-actions-substances-3" aria-expanded="false" data-pinger-ignore> Vaccines, Conjugate </button><div id="keyword-actions-substances-3" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Vaccines, Conjugate"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Vaccines%2C+Conjugate%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Vaccines%2C+Conjugate%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Vaccines, Conjugate"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Vaccines, Conjugate"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Vaccines%2C+Conjugate%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="Vaccines, Conjugate"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Vaccines, Conjugate"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Vaccines, Conjugate"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Yellow Fever Vaccine" tabindex="0" aria-controls="keyword-actions-substances-4" aria-expanded="false" data-pinger-ignore> Yellow Fever Vaccine </button><div id="keyword-actions-substances-4" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Yellow Fever Vaccine"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Yellow+Fever+Vaccine%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Yellow+Fever+Vaccine%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Yellow Fever Vaccine"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Yellow Fever Vaccine"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Yellow+Fever+Vaccine%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="Yellow Fever Vaccine"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Yellow Fever Vaccine"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Yellow Fever Vaccine"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li></ul> </div> <div id="supplemental-data" class="supplemental-data"> <h2 class="title"> Associated data </h2> <ul class="supplemental-data-list"><li><div class="supplemental-data-actions dropdown-block"><button class="supplemental-data-actions-trigger trigger" title="Supplemental Data Dropdown Toggle" ref="linksrc=supplemental_data_actions_btn" tabindex="0" aria-controls="supplemental-data-GEO-GSE13485" aria-describedby="supplemental-data-GEO-GSE13485" data-pinger-ignore> GEO/GSE13485 </button><div id="supplemental-data-GEO-GSE13485" class="supplemental-data-actions-dropdown dropdown dropdown-container" hidden aria-label="GEO/GSE13485"><div class="title">Actions</div><div class="content"><ul class="supplemental-data-actions-links"><li><a class="dropdown-block-link" title="Search in PubMed" href="/?term=GEO%2FGSE13485%5BSecondary+Source+ID%5D" ref="linksrc=ssid_link" data-ga-category="search" data-ga-action="data" data-ga-label="GEO/GSE13485[Secondary Source ID]"> Search in PubMed </a></li><li><a class="dropdown-block-link" title="Search in GEO" href="https://www.ncbi.nlm.nih.gov/projects/geo/query/acc.cgi?acc=GSE13485" ref="linksrc=ssid_link" data-ga-category="search" data-ga-action="data" data-ga-label="None"> Search in GEO </a></li></ul></div></div></div></li><li><div class="supplemental-data-actions dropdown-block"><button class="supplemental-data-actions-trigger trigger" title="Supplemental Data Dropdown Toggle" ref="linksrc=supplemental_data_actions_btn" tabindex="0" aria-controls="supplemental-data-GEO-GSE29615" aria-describedby="supplemental-data-GEO-GSE29615" data-pinger-ignore> GEO/GSE29615 </button><div id="supplemental-data-GEO-GSE29615" class="supplemental-data-actions-dropdown dropdown dropdown-container" hidden aria-label="GEO/GSE29615"><div class="title">Actions</div><div class="content"><ul class="supplemental-data-actions-links"><li><a class="dropdown-block-link" title="Search in PubMed" href="/?term=GEO%2FGSE29615%5BSecondary+Source+ID%5D" ref="linksrc=ssid_link" data-ga-category="search" data-ga-action="data" data-ga-label="GEO/GSE29615[Secondary Source ID]"> Search in PubMed </a></li><li><a class="dropdown-block-link" title="Search in GEO" href="https://www.ncbi.nlm.nih.gov/projects/geo/query/acc.cgi?acc=GSE29615" ref="linksrc=ssid_link" data-ga-category="search" data-ga-action="data" data-ga-label="None"> Search in GEO </a></li></ul></div></div></div></li><li><div class="supplemental-data-actions dropdown-block"><button class="supplemental-data-actions-trigger trigger" title="Supplemental Data Dropdown Toggle" ref="linksrc=supplemental_data_actions_btn" tabindex="0" aria-controls="supplemental-data-GEO-GSE29617" aria-describedby="supplemental-data-GEO-GSE29617" data-pinger-ignore> GEO/GSE29617 </button><div id="supplemental-data-GEO-GSE29617" class="supplemental-data-actions-dropdown dropdown dropdown-container" hidden aria-label="GEO/GSE29617"><div class="title">Actions</div><div class="content"><ul class="supplemental-data-actions-links"><li><a class="dropdown-block-link" title="Search in PubMed" href="/?term=GEO%2FGSE29617%5BSecondary+Source+ID%5D" ref="linksrc=ssid_link" data-ga-category="search" data-ga-action="data" data-ga-label="GEO/GSE29617[Secondary Source ID]"> Search in PubMed </a></li><li><a class="dropdown-block-link" title="Search in GEO" href="https://www.ncbi.nlm.nih.gov/projects/geo/query/acc.cgi?acc=GSE29617" ref="linksrc=ssid_link" data-ga-category="search" data-ga-action="data" data-ga-label="None"> Search in GEO </a></li></ul></div></div></div></li><li><div class="supplemental-data-actions dropdown-block"><button class="supplemental-data-actions-trigger trigger" title="Supplemental Data Dropdown Toggle" ref="linksrc=supplemental_data_actions_btn" tabindex="0" aria-controls="supplemental-data-GEO-GSE52245" aria-describedby="supplemental-data-GEO-GSE52245" data-pinger-ignore> GEO/GSE52245 </button><div id="supplemental-data-GEO-GSE52245" class="supplemental-data-actions-dropdown dropdown dropdown-container" hidden aria-label="GEO/GSE52245"><div class="title">Actions</div><div class="content"><ul class="supplemental-data-actions-links"><li><a class="dropdown-block-link" title="Search in PubMed" href="/?term=GEO%2FGSE52245%5BSecondary+Source+ID%5D" ref="linksrc=ssid_link" data-ga-category="search" data-ga-action="data" data-ga-label="GEO/GSE52245[Secondary Source ID]"> Search in PubMed 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ref="log$=recordlinks&logdbfrom=pubmed&ncbi_uid=24336226&ordinalpos=1&linkpos=3"> Related Project </a></li></ul> </div> <div id="grants" class="grants"> <h2 class="title"> Grants and funding </h2> <div class="grants-list"><ul id="grants-head-list"><li class="grant-item"><a title="All articles for grant R37 AI048638/AI/NIAID NIH HHS/United States" href="/?term=R37+AI048638%2FAI%2FNIAID+NIH+HHS%2FUnited+States%5BGrants+and+Funding%5D&sort=date&sort_order=desc" ref="linksrc=grant_link" data-ga-category="search" data-ga-action="grant" data-ga-label="R37 AI048638" > R37 AI048638/AI/NIAID NIH HHS/United States </a></li><li class="grant-item"><a title="All articles for grant R38 AI140299/AI/NIAID NIH HHS/United States" href="/?term=R38+AI140299%2FAI%2FNIAID+NIH+HHS%2FUnited+States%5BGrants+and+Funding%5D&sort=date&sort_order=desc" ref="linksrc=grant_link" data-ga-category="search" data-ga-action="grant" data-ga-label="R38 AI140299" > R38 AI140299/AI/NIAID NIH HHS/United States </a></li><li 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Molecular signatures of antibody responses derived from a systems biology study of five human vaccines - PubMed