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class="layout-columns__main -padding--vertical -padding--horizontal"> <div class="layout-columns__main__content"> <ul class="content-tease__list"> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <p class="content-tease__topic"> <span class="highlight">Featured</span> </p> <h3 class="content-tease__heading" itemprop="name"> <a href="/digestive-health/journal.aspx?id=1251" itemprop="url"> Is Accelerated Infliximab Induction Beneficial for Severe Ulcerative Colitis?</a> </h3> <p itemprop="description"> <p>While short-interval administration of infliximab was equally efficacious as standard administration for severe ulcerative colitis, a multicenter retrospective study has shown that a higher dose upon initiation reduced the risk of colectomy. </p></p> <p class="content-tease__related"> <a href="/digestive-health/topic.aspx?id=1040" itemprop="relatedLink">Bowel Disease</a>, <a href="/digestive-health/specialty.aspx?id=1007" itemprop="relatedLink">Digestive Health</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2019-03-01" itemprop="datePublished">March 1, 2019</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <p class="content-tease__topic"> <span class="highlight">Featured</span> </p> <h3 class="content-tease__heading" itemprop="name"> <a href="/digestive-health/journal.aspx?id=1248" itemprop="url"> Discovering the Role of C1orf106 in Patients with IBD</a> </h3> <p itemprop="description"> <p>C1orf106 is a known susceptibility gene for inflammatory bowel disease, and now Massachusetts General researchers have identified its role: it "fine tunes" the integrity of the intestinal epithelial barrier.</p></p> <p class="content-tease__related"> <a href="/digestive-health/topic.aspx?id=1040" itemprop="relatedLink">Bowel Disease</a>, <a href="/digestive-health/specialty.aspx?id=1007" itemprop="relatedLink">Digestive Health</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2019-03-15" itemprop="datePublished">March 15, 2019</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <p class="content-tease__topic"> <span class="highlight">Featured</span> </p> <h3 class="content-tease__heading" itemprop="name"> <a href="/digestive-health/journal.aspx?id=1240" itemprop="url"> Obesity Tied to Risk of Diverticulosis</a> </h3> <p itemprop="description"> <p>By analyzing a cohort of adults who underwent colonoscopy, gastroenterologists at Massachusetts General Hospital have determined that overweight and obesity substantially increase the risk of diverticulosis.</p></p> <p class="content-tease__related"> <a href="/digestive-health/topic.aspx?id=1040" itemprop="relatedLink">Bowel Disease</a>, <a href="/digestive-health/specialty.aspx?id=1007" itemprop="relatedLink">Digestive Health</a>, <a href="/digestive-health/topic.aspx?id=1039" itemprop="relatedLink">Obesity</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2019-03-29" itemprop="datePublished">March 29, 2019</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/digestive-health/article-external.aspx?id=1166" itemprop="url"> AGA Guideline Makes the Case for Biomarkers in Managing Crohn's Disease</a> </h3> <p itemprop="description"> <p>Ashwin Ananthakrishnan, MD, discusses the AGA guideline's key recommendations for managing Crohn's disease and the evolving role of biomarkers in these treatments.</p></p> <p class="content-tease__related"> <a href="/digestive-health/topic.aspx?id=1040" itemprop="relatedLink">Bowel Disease</a>, <a href="/digestive-health/specialty.aspx?id=1007" itemprop="relatedLink">Digestive Health</a> </p> <p class="content-metadata"> <span class="content-metadata__media -article">Article</span> <time class="date" datetime="2024-04-11" itemprop="datePublished">April 11, 2024</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/digestive-health/journal.aspx?id=2607" itemprop="url"> Fatigue in Inflammatory Bowel Disease Linked to Substantial Economic Burden</a> </h3> <p itemprop="description"> <p><span>Ashwin N. Ananthakrishnan, MBBS, MPH, and colleagues found that healthcare resource utilization was significantly higher for inflammatory bowel disease (IBD) patients with fatigue than those without. The same was true for IBD-related and all-cause medical and pharmacy costs, regardless of IBD subtype or severity.</span></p></p> <p class="content-tease__related"> <a href="/digestive-health/topic.aspx?id=1040" itemprop="relatedLink">Bowel Disease</a>, <a href="/digestive-health/specialty.aspx?id=1007" itemprop="relatedLink">Digestive Health</a> </p> <p class="content-metadata"> <span class="content-metadata__media -journal">Journal</span> <time class="date" datetime="2024-03-28" itemprop="datePublished">March 28, 2024</time> </p> </div> </li> <li class="content-tease__item"> <div class="content-tease" itemtype="http://schema.org/ScholarlyArticle"> <h3 class="content-tease__heading" itemprop="name"> <a href="/digestive-health/article-external.aspx?id=1164" itemprop="url"> Digital App-based Cognitive Behavioral Therapy Significantly Improves IBS Symptoms</a> </h3> <p itemprop="description"> <p><span>At the American College of Gastroenterology 2023 Scientific Meeting, Mythili Pathipati, MD, presented findings from a real-world study where app-delivered cognitive behavioral therapy resulted in a significant reduction in symptom severity and perceived stress for patients with irritable bowel syndrome.</span></p></p> <p class="content-tease__related"> <a href="/digestive-health/topic.aspx?id=1040" itemprop="relatedLink">Bowel Disease</a>, <a href="/digestive-health/specialty.aspx?id=1007" itemprop="relatedLink">Digestive Health</a>, <a href="/neuro/topic.aspx?id=1017" itemprop="relatedLink">Psychiatry</a>, <a href="/research-and-innovation/topic.aspx?id=1068" itemprop="relatedLink">Telemedicine</a> </p> <p class="content-metadata"> <span class="content-metadata__media -article">Article</span> <time class="date" datetime="2023-11-14" itemprop="datePublished">November 14, 2023</time> </p> </div> </li> </ui> <p class="fat-link__cta u-flush u-text-right"> <a class="fat-link -caret -large" href="https://advances.massgeneral.org/search.aspx?q=*&st=1&topic=bowel%20disease&maxResults=15">View All Bowel Disease Updates</a> </p> </div> </div> </section> <section class="-background--grey -padding--vertical -padding--horizontal"> <div class="content-container -width--wide -centered"> <h2 class="section-heading -centered">Bowel Disease Contributors</h2> <ul class="profile-card__list" id="profile-cards"> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="Andrew Chan, MD, MPH" itemprop="image" srcset="/assets/images/contributors/david_chan_advances.png, /assets/images/contributors/david_chan_advances_2x.png 2x" src="/assets/images/contributors/david_chan_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1318" itemprop="url">Andrew T. Chan, MD, MPH</a> </h3> <p itemprop="jobTitle"> Daniel K. Podolsky Professor of Medicine, Harvard Medical School, Director for Cancer Epidemiology, Mass General Cancer Center, Chief, Clinical and Translational Epidemiology Unit, Department of Medicine</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/digestive-health/article-external.aspx?id=1169">Taking Aspirin Associated With Reduction in Colorectal Cancer Among High-Risk Population</a> </p> </div> <p class="profile-card__image"> <img alt="Andrew Chan, MD, MPH" itemprop="image" srcset="/assets/images/contributors/david_chan_advances.png, /assets/images/contributors/david_chan_advances_2x.png 2x" src="/assets/images/contributors/david_chan_advances.png"> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/ashwin_ananthakrishan_advances.png, /assets/images/contributors/ashwin_ananthakrishan_advances_2x.png 2x" src="/assets/images/contributors/ashwin_ananthakrishan_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1329" itemprop="url">Ashwin N. Ananthakrishnan, MBBS, MPH</a> </h3> <p itemprop="jobTitle"> Director of the Crohn's and Colitis Center, Division of Gastroenterology, Mass General, Associate Professor of Medicine, Harvard Medical School </p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/digestive-health/article-external.aspx?id=1166">AGA Guideline Makes the Case for Biomarkers in Managing Crohn's Disease</a> </p> </div> <p class="profile-card__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/ashwin_ananthakrishan_advances.png, /assets/images/contributors/ashwin_ananthakrishan_advances_2x.png 2x" src="/assets/images/contributors/ashwin_ananthakrishan_advances.png"> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <p class="profile-card__content__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/hamed_khalili_advances.png, /assets/images/contributors/hamed_khalili_advances_2x.png 2x" src="/assets/images/contributors/hamed_khalili_advances.png"> </p> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1324" itemprop="url">Hamed Khalili, MD, MPH</a> </h3> <p itemprop="jobTitle"> Gastroenterologist, Clinical and Translational Epidemiology Unit, Director of Clinical Research in Inflammatory Bowel Disease in the Division of Gastroenterology, Associate Professor of Medicine, Harvard Medical School</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/digestive-health/journal.aspx?id=2316">Initiating Oral Contraception Does Not Change Gut Microbiome in Healthy Women</a> </p> </div> <p class="profile-card__image"> <img alt="" itemprop="image" srcset="/assets/images/contributors/hamed_khalili_advances.png, /assets/images/contributors/hamed_khalili_advances_2x.png 2x" src="/assets/images/contributors/hamed_khalili_advances.png"> </p> </li> <li class="profile-card" itemscope="" itemtype="http://schema.org/Person"> <div class="profile-card__content"> <h3 class="profile-card__name" itemprop="name"> <a href="/contributors/contributor.aspx?id=1319" itemprop="url">Wenjie Ma, MBBS, ScD</a> </h3> <p itemprop="jobTitle"> Instructor and Investigator in the Clinical and Translational Epidemiology Unit, Assistant in Epidemiology in the Division of Gastroenterology, Instructor in Medicine, Harvard Medical School</p> <p class="profile-card__article"> <strong>Recent Article</strong><br> <a href="/digestive-health/journal.aspx?id=2282">Initiating Screening Before Age 50 Reduces Risk of Colorectal Cancer</a> </p> </div> <p class="profile-card__image"> <img alt="" itemprop="image" srcset=", 2x" src=""> </p> </li> </ul> </div> </section> <div class="content-container -width--xwide -centered specialty-block__wrapper" id="specialty-block"> <style> #specialty-block .specialty-block__image { /* 540px */ background-image: 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