Bioavailability Enhancement-BioDuro-Sundia

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src="/upload/image/20241008/9e3a859e2d66a631f1c5bf549da77be8.jpg" class="ipad_banner" /><img src="/upload/image/20241008/43dd253671a66c4de03ebd2a3622bf68.jpg" class="iphone_banner" /></div> <div class="DBanner_title"> <h1 class="DBanner_title_dd">BIOAVAILABILITY ENHANCEMENT</h1> <h3 class="DBanner_title_dt">Rapid in silico, in vitro and in vivo screening techniques to optimize the solubility of ASD formulations</h3> </div> </div> <div class="pc_all IndexBioDuro IndexBioNews BreadCrumbs DDiscovery2 DDiscovery3"> <div class="pc_all_content"> <div class="BreadCrumbs_top"> <a href="/" class=""><img src="/skin/images/bn25.svg" />Home</a> <i class="fa fa-angle-right"></i> <a href="/platforms/">Platforms</a> <i class="fa fa-angle-right"></i> <a href="javascript:void(0)" class="on">Bioavailability Enhancement</a> </div> <div class="DDiscovery2_content"> <div class="DDiscovery2_content_left"> <div class="content_left_bottom"> <div class="left_bottom_list"><div class="bottom_list_title">Bioavailability Enhancement for Oral Solid Dosage Forms</div><div class="bottom_list_txt"><div class="list_txt_title3">Our systematic approach screens formulations with amorphous solid dispersion (ASD) technologies to ensure the drug candidate with the highest oral bioavailability is selected for further development and/or manufacturing.</div><p>In silico computer modelling</p><p>In vitro discriminant analysis</p><p>In vivo ADME and PK studies</p><p>Stability studies</p><p>Formulation screening</p><p>Process scale-up</p><p>cGMP manufacturing</p><p>CTM supply and <a href="https://www.bioduro-sundia.com/services-solutions/drug-product/manufacturing/clinical-manufacturing.html" target="_self" _href="https://www.bioduro-sundia.com/services-solutions/drug-product/manufacturing/clinical-manufacturing.html">clinical manufacturing</a></p><p>Specializations include lipid-based solution and suspension, self-microemulsifying drug delivery system (SMEDDS), nanosuspension and micronization</p><div class="list_txt_img"><img src="/upload/image/20241107/c872fd7bec5aa51c409888b2eccf927b.jpg" _src="/upload/image/20241107/c872fd7bec5aa51c409888b2eccf927b.jpg" width="" height="" border="0" vspace="0" title="" alt=""/></div><div class="list_txt_img"><img src="/upload/image/20241008/83843c1f73306a5511a96675ea73c158.jpg"/></div></div></div><div class="left_bottom_list"><div class="bottom_list_title">ASD Screening Studies: in silico and in vivo</div><div class="bottom_list_txt"><div class="list_txt_title3">BioDuro-Sundia ASD screening studies leverage in silico methods based on the Flory-Huggins solution theory to select drug-polymer combinations with the highest chance of miscibility based on estimated solubility parameters and potential for polar, dipole and ionic interactions. Subsequent in vivo PK studies determine drug-polymer combinations with the highest oral bioavailability.</div></div></div><div class="left_bottom_list"><div class="bottom_list_title">ASD Stability Studies: SDD and HME</div><div class="bottom_list_txt"><div class="list_txt_title3">Next, ASD stability studies utilize small-scale spray dried dispersion (SDD) and/or hot melt extrusion (HME) to characterize drug-polymer combinations for amorphous content determination (XRPD), thermal properties (mDSC and TGA), assay/related substance and in-vitro non-sink dissolution before being staged in ICH accelerated stability chambers. The ASDs with the highest stability proceed to further in vivo PK studies and selected for process scale-up and manufacturing.</div></div></div><div class="left_bottom_list"><div class="bottom_list_title">ASD Process Scale-Up and Manufacturing</div><div class="bottom_list_txt"><div class="list_txt_title3">BioDuro-Sundia ASD process development and cGMP manufacturing capabilities enable downstream process and manufacturing of finished oral solid dosage forms (tablets and capsules). The process of SDD and/or HME is scaled-up for engineering process development. Finally, cGMP manufacturing, packaging, labeling (open or blinded) and clinical site distribution completes full-service supply of clinical trial material (CTM).</div></div></div><div class="left_bottom_list"><div class="bottom_list_title">Contact Us</div><div class="bottom_list_txt"><div class="list_txt_title3"><a href="https://www.bioduro-sundia.com/contact-us/" target="_self" _href="https://www.bioduro-sundia.com/contact-us/">Click here</a> or email hello@bioduro-sundia.com to get in contact with a BioDuro-Sundia representative. By combining in silico computer modeling, in vitro screening and in vivo PK with cGMP manufacturing, our unique approach optimizes ASDs for high oral bioavailability.</div></div></div> </div> </div> <div class="DDiscovery2_content_right"> <div class="content_right_list "> <a href="/platforms/peptide-chemistry.html" class="right_list_title"> <div class="list_title_dd">Peptide Drug Discovery</div> <div class="list_title_dt"><img src="/skin/images/bn41.svg" /><img src="/skin/images/bn41on.svg" /> </div> </a> </div> <div class="content_right_list "> <a href="/platforms/compound-management.html" class="right_list_title"> <div class="list_title_dd">Compound Management</div> <div class="list_title_dt"><img src="/skin/images/bn41.svg" /><img src="/skin/images/bn41on.svg" /> </div> </a> </div> <div class="content_right_list "> <a href="/platforms/protac.html" class="right_list_title"> <div class="list_title_dd">PROTAC Drug Discovery</div> <div class="list_title_dt"><img src="/skin/images/bn41.svg" /><img src="/skin/images/bn41on.svg" /> </div> </a> </div> <div class="content_right_list on"> <a href="/platforms/solution-engine.html" class="right_list_title"> <div class="list_title_dd">Bioavailability Enhancement</div> <div class="list_title_dt"><img src="/skin/images/bn41.svg" /><img src="/skin/images/bn41on.svg" /> </div> </a> </div> <div class="content_right_list "> <a href="/platforms/integrated-drug-discovery.html" class="right_list_title"> <div class="list_title_dd">Integrated Drug Discovery</div> <div class="list_title_dt"><img src="/skin/images/bn41.svg" /><img src="/skin/images/bn41on.svg" /> </div> </a> </div> <div class="content_right_list "> <a href="/platforms/ind-enabling.html" class="right_list_title"> <div class="list_title_dd">IND Enabling</div> <div class="list_title_dt"><img src="/skin/images/bn41.svg" /><img src="/skin/images/bn41on.svg" /> </div> </a> </div> <div class="content_right_list "> <a href="/platforms/dna-encoded-library-del.html" class="right_list_title"> <div class="list_title_dd">DNA-Encoded Library</div> <div class="list_title_dt"><img src="/skin/images/bn41.svg" /><img src="/skin/images/bn41on.svg" /> </div> </a> </div> <div class="content_right_list "> <a href="/platforms/nash.html" class="right_list_title"> <div class="list_title_dd">Preclinical MASH Models</div> <div class="list_title_dt"><img src="/skin/images/bn41.svg" /><img src="/skin/images/bn41on.svg" /> </div> </a> </div> </div> </div> </div> </div> <div class="pc_all Footer"> <div class="pc_all_content"> <div class="Footer_top"> <div class="Footer_top_left"> <div class="top_left_icon"><img src="/skin/images/bn14.svg" /></div> <div class="top_left_txt"> <div class="left_txt_dd">Subscribe to BioDuro-Sundia</div> <div class="left_txt_dt">Receive our newsletter and information on upcoming events</div> </div> </div> <form action="/index/Feedback/add.html" method="post" class="feedback Footer_top_right" onsubmit="return save_form(this,function(){alert('Successfully subscribed！');history.go(0)})"> <input type="hidden" name="catid" value="8"> <input type="text" name="email" class="info_email" placeholder="Your email address" /> <input type="submit" value="Sign up" class="submit_btn" /> </form> </div> <div class="Footer_bottom"> <div class="Footer_bottom_left"> <div class="bottom_left_logo"><img src="/skin/images/logo2.svg" /></div> <div class="bottom_left_title">Your trusted partner from drug discovery and <br>development to commercialization</div> <div class="bottom_left_share"> <a href="https://www.linkedin.com/company/biodurosundia/" target="_blank"><i class="fa fa-linkedin"></i></a> <a href="javascript:void(0)"><i class="fa fa-weixin"></i><div class="left_share_down"><img src="/skin/images/wchat.jpg" /></div></a> </div> </div> <div class="Footer_bottom_right"> <div class="bottom_right_list"> <p><a href="/">Home</a></p> <p><a href="/about-us/">About us</a></p><p><a href="/services-solutions/">Services & Solutions</a></p><p><a href="/platforms/">Platforms</a></p> </div> <div class="bottom_right_list"> <p><a href="/news-resources/">News & Resources</a></p><p><a href="/careers/">Careers</a></p><p><a href="/contact-us/">Contact us</a></p> </div> <div class="bottom_right_list"> <p><a href="javascript:void(0)">Explore <img src="/skin/images/bn1.svg" /></a></p> <p><a href="/services-solutions/discovery/">Discovery <img src="/skin/images/bn15.svg" /></a></p> <p><a href="/services-solutions/drug-substance/">Drug Substance <img src="/skin/images/bn15.svg" /></a></p> <p><a href="/services-solutions/drug-product/">Drug Product <img src="/skin/images/bn15.svg" /></a></p> </div> </div> </div> <div class="Footer_cor"> <div class="Footer_cor_left">© 2023 BioDuro-Sundia. 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