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Parvovirus B19 changes iron homeostasis during pathological | 12317
<!DOCTYPE html> <html lang="hi"> <head> <meta charset="utf-8"> <meta name="viewport" content="width=device-width, initial-scale=1"> <title>Parvovirus B19 changes iron homeostasis during pathological | 12317</title> <meta name="keywords" content="Voleva S, Manolov V*, Angelova S, Vasilev V, Gramatikova Z, Bogov I, Marinov B & Shishkov S, "/> <meta name="description" content="Objective: Viral infections during pregnancies are one of the main reasons for mother and fetus severe complications and mortality. Infections are associat..12317"/> <meta name="citation_publisher" content="खुली पहुंच वाली पत्रिकाएँ" /> <meta name="citation_journal_title" content="क्लिनिक के जरिए डॉक्टर की प्रैक्टिस"> <meta name="citation_title" content="Parvovirus B19 changes iron homeostasis during pathological pregnancy"> <meta name="citation_author" content="Voleva S" /> <meta name="citation_author" content="Manolov V" /> <meta name="citation_author" content="Angelova S" /> <meta name="citation_author" content="Vasilev V" /> <meta name="citation_author" content="Gramatikova Z" /> <meta name="citation_author" content="Bogov I" /> <meta name="citation_author" content="Marinov B & Shishkov S" /> <meta name="citation_year" content=""> <meta name="citation_volume" content="15"> <meta name="citation_issue" content="1"> <meta name="citation_abstract" content="Objective: Viral infections during pregnancies are one of the main reasons for mother and fetus severe complications and mortality. Infections are associated with significant changes in iron homeostasis. The post-infectious anemic syndrome is characterized by low serum iron and increased hepcidin, which accumulates iron in endothelial macrophage system. The study aims to find the involvement of parvovirus B19 in the anemic syndrome development during pathological pregnancy. Methods: 52 pregnant women with anemia, diagnosed and hospitalized in University Obstetrics and Gynaecology “Maichin Dom” hospital were enrolled. The serological (indirect Enzyme-Linked Immunosorbent Assay (ELISA) tests) and molecular (B19V- Polymerase Chain Reaction (PCR) test) methods were used. In anemic pregnant women were evaluated iron homeostasis parameters with CLIA, ELISA and Ferrozine methods. For statistical evaluation of results the researchers used SPSS 13.0 (IBM). Correlations and significance were rated by Student’s paired t-test and Pearson’s correlation. Results: 8/52 (15.4%) of patients showed presence of B19V-IgM antibodies. B19-IgG antibodies were detected in 21/52 (40.4%) women. A positive PCR signal was determined in all patients with positive B19V-IgM, and 1 patient with anemia and positive B19V-IgG result. In two pregnant and positive women for acute viral B19V infection, anemia was classified as iron-deficiency, based on low serum hepcidin concentration 2.19 ± 0.5 µg/l, compared to 20.4 ± 2.9 µg/l pregnant women without B19V infection (ÃÂ <0.001). In other acute B19V infection women we found statistically increased serum hepcidin concentrations (61.9 ± 6.2 µg/l), ÃÂ <0.001. Conclusion: Because of transplanted pathway of parvovirus B19 infection transmission, in combination to B19V affinity for hematopoietic cell systems quantification of serum hepcidin levels would contribute for etiological clarification of anemia and prevention from inadequate iron supplementation in pregnant women. 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class="col-md-7 sm-margin-b-30"> <h2 class="breadcrumbs-v5-title">क्लिनिक के जरिए डॉक्टर की प्रैक्टिस</h2> </div> </div> </div> </section> <style> .breadcrumbs-v5 { position: relative; z-index: 1; background: url(https://www.openaccessjournals.com/admin/banners/clinical-practice-therapy-banner.jpg) no-repeat; background-size: cover; background-position: 50% 20%; padding: 80px 0 80px; text-align:center; } .breadcrumbs-v5 .breadcrumbs-v5-title { font-size: 60px; } #issn{ line-height:30px; color:#fff; } </style> <div class="bg-color-sky-light"> <!--========== PAGE CONTENT ==========--> <div class="content container"> <div class="row"> <div class="col-md-12 md-margin-b-50"> <!-- Blog Grid --> <article class="blog-grid margin-b-30"> <div class="blog-grid-content"> <!-- <h2 class="blog-grid-title-lg">Abstract</h2> --> <h3 class="blog-grid-title-lg">अमूर्त</h3> <h1 class="fweight-400 font-size-26"> Parvovirus B19 changes iron homeostasis during pathological pregnancy </h1> Voleva S, Manolov V*, Angelova S, Vasilev V, Gramatikova Z, Bogov I, Marinov B & Shishkov S<br /><br /> <p>Objective: Viral infections during pregnancies are one of the main reasons for mother and fetus severe complications and mortality. Infections are associated with significant changes in iron homeostasis. The post-infectious anemic syndrome is characterized by low serum iron and increased hepcidin, which accumulates iron in endothelial macrophage system. The study aims to find the involvement of parvovirus B19 in the anemic syndrome development during pathological pregnancy. Methods: 52 pregnant women with anemia, diagnosed and hospitalized in University Obstetrics and Gynaecology “Maichin Dom” hospital were enrolled. The serological (indirect Enzyme-Linked Immunosorbent Assay (ELISA) tests) and molecular (B19V- Polymerase Chain Reaction (PCR) test) methods were used. In anemic pregnant women were evaluated iron homeostasis parameters with CLIA, ELISA and Ferrozine methods. For statistical evaluation of results the researchers used SPSS 13.0 (IBM). Correlations and significance were rated by Student’s paired t-test and Pearson’s correlation. Results: 8/52 (15.4%) of patients showed presence of B19V-IgM antibodies. B19-IgG antibodies were detected in 21/52 (40.4%) women. A positive PCR signal was determined in all patients with positive B19V-IgM, and 1 patient with anemia and positive B19V-IgG result. In two pregnant and positive women for acute viral B19V infection, anemia was classified as iron-deficiency, based on low serum hepcidin concentration 2.19 ± 0.5 µg/l, compared to 20.4 ± 2.9 µg/l pregnant women without B19V infection (ÃÂ <0.001). In other acute B19V infection women we found statistically increased serum hepcidin concentrations (61.9 ± 6.2 µg/l), ÃÂ <0.001. Conclusion: Because of transplanted pathway of parvovirus B19 infection transmission, in combination to B19V affinity for hematopoietic cell systems quantification of serum hepcidin levels would contribute for etiological clarification of anemia and prevention from inadequate iron supplementation in pregnant women.</p> <div class="alert alert-info text-left"><b>अस्वीकृति:</b> इस सारांश का अनुवाद कृत्रिम बुद्धिमत्ता उपकरणों का उपयोग करके किया गया है और इसे अभी तक समीक्षा या सत्यापित नहीं किया गया है।</div> </div> </article> </div> </div> </div> </div> <!--========== FOOTER V2 ==========--> <footer id="footer" class="cu_footer"> <div class="container"> <div class="row padding-t-20 padding-b-20"> <div class="col-md-10"> <ul> <li ><a href="https://hindi.openaccessjournals.com/">घर</a></li> <li ><a href="https://hindi.openaccessjournals.com/about-us.html">हमारे बारे में</a></li> <li ><a href="https://hindi.openaccessjournals.com/journals.html">पत्रिकाओं</a></li> <li ><a href="https://hindi.openaccessjournals.com/instructionsforauthors.html">लेखक दिशानिर्देश</a></li> <li ><a href="https://hindi.openaccessjournals.com/contact-us.html">संपर्क करें</a></li> </ul> <!-- End Menu List --> </div> <div class="col-md-2"> <!-- Theme Icons Base On Hover --> <ul class="list-inline ul-li-lr-2 text-right sm-text-center margin-b-0"> <li class="animate-theme-icons"> <a class="animate-theme-icons-body animate-theme-icons-white-bg theme-icons-md radius-3" href="https://www.facebook.com/profile.php?id=100076418779107" target="_blank"> <i class="animate-theme-icons-element fa fa-facebook"></i> </a> </li> <li class="animate-theme-icons"> <a class="animate-theme-icons-body animate-theme-icons-white-bg theme-icons-md radius-3" href="https://twitter.com/OpenaccessJ" target="_blank"> <i class="animate-theme-icons-element fa fa-twitter"></i> </a> </li> <li class="animate-theme-icons"> <a class="animate-theme-icons-body animate-theme-icons-white-bg theme-icons-md radius-3" href="https://www.linkedin.com/company/open-access-journal" target="_blank"> <i class="animate-theme-icons-element fa fa-linkedin"></i> </a> </li> <li class="animate-theme-icons"> <a class="animate-theme-icons-body animate-theme-icons-white-bg theme-icons-md radius-3" href="https://www.instagram.com/openaccess_journals/" target="_blank"> <i class="animate-theme-icons-element fa fa-instagram"></i> </a> </li> </ul> <!-- End Theme Icons Base On Hover --> </div> </div> <!-- Copyright --> <div class="footer-v2-copyright"> <p class="pclas"><a href="https://hindi.openaccessjournals.com/" title="यहाँ क्लिक करें" class="color-white">खुली पहुंच वाली पत्रिकाएँ</a> © 2024</p> </div> <!-- End Copyright --> </div> <div class="app-view"> Get the App <p><a href="https://play.google.com/store/apps/details?id=com.journals.openaccessjournals" target="_blank"><i class="fa fa-android" aria-hidden="true"></i></a></p> </div> </footer> <!--========== END FOOTER V2 ==========--> <!-- END WRAPPER --> <!-- Sidebar Content Overlay --> <div class="sidebar-content-overlay"></div> <!-- End Sidebar Content Overlay --> <!-- Back To Top --> <a href="javascript:void(0);" class="js-back-to-top back-to-top-theme"></a> <script async type="text/javascript" src="https://hindi.openaccessjournals.com/assets/plugins/jquery.migrate.min.js"></script> <script async type="text/javascript" src="https://hindi.openaccessjournals.com/assets/plugins/bootstrap/js/bootstrap.min.js"></script> <!-- END CORE PLUGINS --> <!-- BEGIN PAGE LEVEL PLUGINS --> <script async type="text/javascript" src="https://hindi.openaccessjournals.com/assets/plugins/jquery.back-to-top.js"></script> <script async type="text/javascript" src="https://hindi.openaccessjournals.com/assets/plugins/jquery.equal-height.js"></script> <!-- BEGIN PAGE LEVEL SCRIPTS --> <!-- END PAGE LEVEL SCRIPTS --> <script async src="https://app.wabi-app.com/widget/js/wabi.js?phone_number=+44-1704-335730&lang=en&position=left"></script> <!--========== END JAVASCRIPTS ==========--></div> </body> </html>