Single-dose ciraparantag safely and completely reverses anticoagulant effects of edoxaban

<!DOCTYPE html> <html lang="en" > <head itemscope itemtype="http://schema.org/WebPage" prefix="og: http://ogp.me/ns#" > <meta charset="UTF-8"> <meta http-equiv="X-UA-Compatible" content="IE=edge">  <meta name="HandheldFriendly" content="True"> <meta name="MobileOptimized" content="320"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link rel="preconnect" href="https://cdn.ncbi.nlm.nih.gov"> <link rel="preconnect" href="https://www.ncbi.nlm.nih.gov"> <link rel="preconnect" href="https://www.google-analytics.com"> <link rel="stylesheet" href="https://cdn.ncbi.nlm.nih.gov/pubmed/0d576970-ea4f-4f8d-9bab-bf51569c42d2/CACHE/css/output.5ecf62baa0fa.css" type="text/css"> <link rel="stylesheet" href="https://cdn.ncbi.nlm.nih.gov/pubmed/0d576970-ea4f-4f8d-9bab-bf51569c42d2/CACHE/css/output.452c70ce66f7.css" type="text/css"> <link rel="stylesheet" href="https://cdn.ncbi.nlm.nih.gov/pubmed/0d576970-ea4f-4f8d-9bab-bf51569c42d2/CACHE/css/output.7bf600913d6e.css" type="text/css"> <link rel="stylesheet" href="https://cdn.ncbi.nlm.nih.gov/pubmed/0d576970-ea4f-4f8d-9bab-bf51569c42d2/CACHE/css/output.0bfa59184c7a.css" type="text/css"> <link rel="stylesheet" href="https://cdn.ncbi.nlm.nih.gov/pubmed/0d576970-ea4f-4f8d-9bab-bf51569c42d2/CACHE/css/output.b576742ffc3e.css" type="text/css"> <title>Single-dose ciraparantag safely and completely reverses anticoagulant effects of edoxaban - PubMed</title> <link rel="preload" as="font" href="https://cdn.ncbi.nlm.nih.gov/pubmed/0d576970-ea4f-4f8d-9bab-bf51569c42d2/uswds/dist/fonts/merriweather-bold-webfont.woff2" type="font/woff2" crossorigin />  <link rel="shortcut icon" type="image/ico" href="https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/favicons/favicon.ico" /> <link rel="icon" type="image/png" href="https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/favicons/favicon.png" />  <link rel="icon" type="image/png" sizes="192x192" href="https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/favicons/favicon-192.png" />  <link rel="apple-touch-icon-precomposed" href="https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/favicons/favicon-57.png">  <link rel="apple-touch-icon-precomposed" sizes="72x72" href="https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/favicons/favicon-72.png">  <link rel="apple-touch-icon-precomposed" sizes="114x114" href="https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/favicons/favicon-114.png">  <link rel="apple-touch-icon-precomposed" sizes="144x144" href="https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/favicons/favicon-144.png">  <meta name="ncbi_sg_optimize_id" content="">  <meta name="theme-color" content="#20558a">  <meta name="referrer" content="origin-when-cross-origin"> <meta name="ncbi_pinger_gtm_track" content="true"/>  <meta name="ncbi_app" content="pubmed" /> <meta name="ncbi_db" content="pubmed" /> <meta name="ncbi_phid" content="E7D2000161D7F445000031220F525F85.1.m_6" /> <meta name="ncbi_pinger_stat_url" content="https://www.ncbi.nlm.nih.gov/stat" /> <meta name="log_category" content="literature" /> <meta name="ncbi_cost_center" content="pubmed" />  <meta name="ncbi_pdid" content="abstract" /> <meta name="log_op" content="retrieve" /> <meta name="uid" content="27853809" /> <meta name="ncbi_uid" content="27853809" /> <meta name="log_displayeduids" content="27853809" /> <meta name="log_source_db" content="pubmed,pmc" /> <meta name="log_icons_present" content="true" />  <meta name="description" content="Of the new direct oral anticoagulants, direct factor Xa inhibitors are limited by the absence of a proven reversal agent. We assessed the safety, tolerability and impact on anticoagulation reversal of ciraparantag (PER977) alone and following a 60 mg dose of the FXa inhibitor edoxaban. Escalating, s …"><meta name="keywords" content="pmid:27853809, PMC6260118, doi:10.1160/TH16-03-0224, Clinical Trial, Phase I, Randomized Controlled Trial, Jack E Ansell, Sasha H Bakhru, James C Costin, Administration, Oral, Adult, Arginine / administration & dosage, Arginine / adverse effects, Arginine / analogs & derivatives*, Arginine / pharmacokinetics, Blood Coagulation / drug effects*, Double-Blind Method, Drug Monitoring / methods, Factor Xa Inhibitors / administration & dosage*, Factor Xa Inhibitors / adverse effects, Humans, Injections, Intravenous, Male, North Carolina, Piperazines / administration & dosage*, Piperazines / adverse effects, Piperazines / pharmacokinetics, Pyridines / administration & dosage*, Pyridines / adverse effects, Thiazoles / administration & dosage*, Thiazoles / adverse effects, Whole Blood Coagulation Time, PubMed Abstract, NIH, NLM, NCBI, National Institutes of Health, National Center for Biotechnology Information, National Library of Medicine, MEDLINE"><meta name="robots" content="index,nofollow,noarchive"><meta property="og:title" content="Single-dose ciraparantag safely and completely reverses anticoagulant effects of edoxaban - PubMed"><meta property="og:url" content="https://pubmed.ncbi.nlm.nih.gov/27853809/"><meta property="og:description" content="Of the new direct oral anticoagulants, direct factor Xa inhibitors are limited by the absence of a proven reversal agent. We assessed the safety, tolerability and impact on anticoagulation reversal of ciraparantag (PER977) alone and following a 60 mg dose of the FXa inhibitor edoxaban. Escalating, s …"><meta property="og:image" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg"><meta property="og:image:secure_url" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg"><meta property="og:type" content="website"><meta property="og:site_name" content="PubMed"><meta name="twitter:domain" content="pubmed.ncbi.nlm.nih.gov"><meta name="twitter:card" content="summary_large_image"><meta name="twitter:title" content="Single-dose ciraparantag safely and completely reverses anticoagulant effects of edoxaban - PubMed"><meta name="twitter:url" content="https://pubmed.ncbi.nlm.nih.gov/27853809/"><meta name="twitter:description" content="Of the new direct oral anticoagulants, direct factor Xa inhibitors are limited by the absence of a proven reversal agent. We assessed the safety, tolerability and impact on anticoagulation reversal of ciraparantag (PER977) alone and following a 60 mg dose of the FXa inhibitor edoxaban. Escalating, s …"><meta name="twitter:image" content="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg">  <link rel="search" type="application/opensearchdescription+xml" href="https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/opensearch.xml" title="PubMed search">  <noscript> <link rel="stylesheet" type="text/css" href="https://cdn.ncbi.nlm.nih.gov/pubmed/0d576970-ea4f-4f8d-9bab-bf51569c42d2/core/no-script.css"> </noscript> <meta name="citation_title" content="Single-dose ciraparantag safely and completely reverses anticoagulant effects of edoxaban"> <meta name="citation_authors" content="Ansell JE;Bakhru SH;Laulicht BE;Steiner SS;Grosso MA;Brown K;Dishy V;Lanz HJ;Mercuri MF;Noveck RJ;Costin JC;"> <meta name="citation_date" content="01/26/2017"> <meta name="citation_publisher" content="Thromb Haemost"> <meta name="citation_journal_title" content="Thrombosis and haemostasis"> <meta name="citation_pmid" content="27853809"> <meta name="citation_abstract_html_url" content="https://pubmed.ncbi.nlm.nih.gov/27853809/"> <meta name="citation_volume" content="117"> <meta name="citation_issue" content="2"> <meta name="citation_doi" content="10.1160/TH16-03-0224"> <meta name="citation_issn" content="2567-689X"> <link rel="canonical" href="https://pubmed.ncbi.nlm.nih.gov/27853809/" /> </head> <body > <noscript> <div class="no-script-banner" id="no-script-banner"> <div class="warning-message"> <div class="warning-message-text"> This site needs JavaScript to work properly. 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new collection</label> </li> <li> <input type="radio" id="collections-action-panel-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="save_share" data-ga-action="collections" data-ga-label="collections_radio_existing"> <label for="collections-action-panel-existing">Add to an existing collection</label> </li> </ul> </div> <div class="controls-wrapper"> <div class="action-panel-control-wrap new-collections-controls"> <label for="collections-action-panel-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label> <input type="text" name="add-to-new-collection" id="collections-action-panel-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="save_share" data-ga-action="create_collection" data-ga-label="non_favorties_collection"> <div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div> </div> <div class="action-panel-control-wrap existing-collections-controls"> <label for="collections-action-panel-add-to-existing" class="action-panel-label"> Choose a collection: </label> <select id="collections-action-panel-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="save_share" data-ga-action="select_collection" data-ga-label="($('#collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"> </select> <div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br> <a href="#">Please try again</a> </div> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="save_share" data-ga-action="collections" data-ga-label="add"> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="collections" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="bibliography-action-panel" class="bibliography-action-panel action-panel in-progress-dots-panel" aria-hidden="true" data-bibliography-open-panel-enabled="false" data-bibliography-open-panel-url-hash="#open-bibliography-panel"> <div class="inner-wrap"> <h3 class="action-panel-heading"> Add to My Bibliography </h3> <form id="bibliography-action-panel-form" class="bibliography-action-panel-form action-panel-content action-form action-panel-smaller-selectors" data-add-to-bibliography-max-amount="100" data-add-to-bibliography-batch-size="10" data-bibliography-delegates-url="/list-bibliography-delegates/" data-add-to-bibliography-url="/add-to-bibliography/" data-get-article-ids-by-search-url="/get-article-ids-by-search/" data-mybib-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/mybibliography/"> <input type="hidden" name="csrfmiddlewaretoken" value="0nlv9T5yvJUNswVlv8gYpfQWCgpG8BsbCWBBFMkQih3CeSJdb4SinsG9z2DylZsm"> <div class="action-panel-control-wrap bibliographies-controls"> <div class="choice-group"> <ul class="bibliographies-action-add radio-group-items"> <li> <input name="bibliography" id="my-bibliography" class="my-bibliography" type="radio" checked/> <label for="my-bibliography">My Bibliography</label> </li> </ul> </div> </div> <div class="bibliographies-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your delegates due to an error<br> <a href="#">Please try again</a> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore> Add </button> <button class="action-panel-cancel" aria-label="Close 'Add to bibliography' panel" ref="linksrc=close_bibliography_panel" aria-controls="bibliography-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="mybib" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="saved-search-action-panel" class="saved-search-action-panel action-panel " aria-hidden="true" data-saved-search-open-panel-enabled="false" data-saved-search-open-panel-url-hash="#open-saved-search-panel"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your saved search </h2> <form id="saved-search-action-panel-form" class="saved-search-action-panel-form action-panel-content action-form" data-create-saved-search-url="/create-saved-search/" data-try-search-terms-url="/try-search-term/" data-saved-search-root-url="https://www.ncbi.nlm.nih.gov/myncbi/searches/"> <input type="hidden" name="csrfmiddlewaretoken" value="0nlv9T5yvJUNswVlv8gYpfQWCgpG8BsbCWBBFMkQih3CeSJdb4SinsG9z2DylZsm"> <div class="action-panel-control-wrap"> <label for="saved-search-name" class="action-panel-label saved-search-name-label required-field-asterisk"> Name of saved search: </label> <input maxlength="200" type="text" name="saved-search-name" id="saved-search-name" class="saved-search-name" value="" required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="action-panel-control-wrap"> <label for="saved-search-term" class="action-panel-label required-field-asterisk"> Search terms: </label> <textarea name="saved-search-term" id="saved-search-term" class="saved-search-term" required></textarea> </div> <div class="test-search-term-wrap"> <a href="#" class="try-search-term">Test search terms</a> </div> <div class="choice-group action-panel-extra-margin-top"> <span class="action-panel-label" id="fieldset-label"> Would you like email updates of new search results? </span> <fieldset id="saved-search-alert" aria-describedby="fieldset-label"> <legend class="usa-sr-only">Saved Search Alert Radio Buttons</legend> <ul class="radio-group-items"> <li> <input type="radio" id="saved-search-alert-yes" class="saved-search-alert-yes" name="saved-search-alert" value="yes" checked> <label for="saved-search-alert-yes" class="action-panel-label">Yes</label> </li> <li> <input aria-label="No radio input" type="radio" id="saved-search-alert-no" class="saved-search-alert-no" name="saved-search-alert" value="no"> <label for="saved-search-alert-no" class="action-panel-label">No</label> </li> </ul> </fieldset> </div> <div class="alert-schedule-wrap"> <div class="action-panel-control-wrap"> <label class="action-panel-label"> Email: </label> <span aria-label="Email address" id="saved-search-email" class="action-panel-label"><span class="action-panel-label-bold"></span> (<a class="myncbi-account-settings" href="https://www.ncbi.nlm.nih.gov/account/settings/">change</a>)</span> </div> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="saved-search-frequency" class="action-panel-label"> Frequency: </label> <select id="saved-search-frequency" class="no-border-panel-selector saved-search-frequency"> <option value="monthly">Monthly</option> <option value="weekly">Weekly</option> <option value="daily">Daily</option> </select> </div> <div class="action-panel-control-wrap saved-search-monthly-additional"> <label for="saved-search-monthly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-monthly-on-day" class="no-border-panel-selector"> <option value="Sunday">The first Sunday</option> <option value="Monday">The first Monday</option> <option value="Tuesday">The first Tuesday</option> <option value="Wednesday">The first Wednesday</option> <option value="Thursday">The first Thursday</option> <option value="Friday">The first Friday</option> <option value="Saturday">The first Saturday</option> <option value="day">The first day</option> <option value="weekday">The first weekday</option> </select> </div> <div class="action-panel-control-wrap saved-search-weekly-additional"> <label for="saved-search-weekly-on-day" class="action-panel-label"> Which day? </label> <select id="saved-search-weekly-on-day" class="no-border-panel-selector saved-search-weekly-on-day"> <option value="Sunday">Sunday</option> <option value="Monday">Monday</option> <option value="Tuesday">Tuesday</option> <option value="Wednesday">Wednesday</option> <option value="Thursday">Thursday</option> <option value="Friday">Friday</option> <option value="Saturday">Saturday</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-report" class="action-panel-label"> Report format: </label> <select id="saved-search-report" class="no-border-panel-selector saved-search-report"> <option value="DocSum">Summary</option> <option value="DocSumText">Summary (text)</option> <option value="Abstract">Abstract</option> <option value="AbstractText">Abstract (text)</option> <option value="MEDLINE">PubMed</option> </select> </div> <div class="action-panel-control-wrap"> <label for="saved-search-amount" class="action-panel-label"> Send at most: </label> <select id="saved-search-amount" class="no-border-panel-selector saved-search-amount"> <option value="1">1 item</option> <option value="5" selected>5 items</option> <option value="10">10 items</option> <option value="20">20 items</option> <option value="50">50 items</option> <option value="100">100 items</option> <option value="200">200 items</option> </select> </div> <div> <input type="checkbox" id="saved-search-send-if-no-result" class="saved-search-send-if-no-result" name="saved-search-send-if-no-result"> <label for="saved-search-send-if-no-result" class="action-panel-label smaller-checkbox"> Send even when there aren't any new results </label> </div> <div class="action-panel-control-wrap option-text-in-email-wrap"> <label for="saved-search-email-text" class="action-panel-label"> Optional text in email: </label> <textarea name="saved-search-email-text" id="saved-search-email-text" class="saved-search-email-text"></textarea> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Saving..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Save </button> <button class="action-panel-cancel" aria-label="Close 'Your saved search' panel" ref="linksrc=close_saved_search_panel" aria-controls="saved-search-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="citation-manager-action-panel" class="citation-manager-action-panel action-panel" aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Create a file for external citation management software </h2> <form id="citation-manager-action-panel-form" class="action-panel-content action-form" action="/results-export-ids/" data-by-search-action="/results-export-search-data/" data-by-ids-action="/results-export-ids/" method="post" data-by-search-method="post" data-by-ids-method="post"> <input type="hidden" name="csrfmiddlewaretoken" value="0nlv9T5yvJUNswVlv8gYpfQWCgpG8BsbCWBBFMkQih3CeSJdb4SinsG9z2DylZsm"> <input name="results-format" type="hidden" value="pubmed"/> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Sending..." data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="save"> Create file </button> <button class="action-panel-cancel" aria-label="Close 'Send citations to citation manager' panel" ref="linksrc=close_citation_manager_panel" aria-controls="citation-manager-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="citation_manager" data-ga-label="cancel"> Cancel </button> </div> </form> </div> </div> <div id="rss-action-panel" class="rss-action-panel action-panel " aria-hidden="true"> <div class="inner-wrap"> <h2 class="action-panel-heading"> Your RSS Feed </h2> <form id="rss-action-panel-form" class="rss-action-panel-form action-panel-content action-form" data-create-rss-feed-url="/create-rss-feed-url/" data-search-form-term-value=""> <input type="hidden" name="csrfmiddlewaretoken" value="0nlv9T5yvJUNswVlv8gYpfQWCgpG8BsbCWBBFMkQih3CeSJdb4SinsG9z2DylZsm"> <div class="action-panel-control-wrap"> <label for="rss-name" class="action-panel-label required-field-asterisk"> Name of RSS Feed: </label> <input maxlength="200" placeholder="Name" type="text" name="rss-name" id="rss-name" class="rss-name" value='' required pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/"> </div> <div class="rss-limit-wrap"> <div class="action-panel-control-wrap action-panel-extra-margin-top"> <label for="rss-limit" class="action-panel-label"> Number of items displayed: </label> <select id="rss-limit" class="no-border-panel-selector rss-limit"> <option value="5">5</option> <option value="10">10</option> <option value="15" selected="selected">15</option> <option value="20">20</option> <option value="50">50</option> <option value="100">100</option> </select> </div> </div> <div class="action-panel-actions"> <button class="action-panel-submit" type="submit" data-loading-label="Creating..." data-ga-category="save_share" data-ga-action="alert" data-ga-label="save"> Create RSS </button> <button class="action-panel-cancel" aria-label="Close 'Your RSS' panel" ref="linksrc=close_rss_panel" aria-controls="rss-action-panel" aria-expanded="false" data-ga-category="save_share" data-ga-action="alert" data-ga-label="cancel"> Cancel </button> </div> <div class="action-panel-control-wrap rss-link-copy-wrap"> <label for="rss-link" class="usa-sr-only">RSS Link</label> <input placeholder="Your RSS Feed Link" type="text" name="rss-link" id="rss-link" class="rss-link" title="RSS Link"> <button type="button" disabled class="rss-link-copy-button disabled" data-ga-category="save_share" data-ga-action="rss" data-ga-label="copy"> Copy </button> </div> </form> </div> </div> </div> </div> <div class="article-page" id="article-page" data-article-pmid="27853809"> <aside class="page-sidebar"> <div class="inner-wrap"> <div class="full-text-links"> <div class="full-view"> <h3 class="title"> Full text links </h3> <div class="full-text-links-list"> <a class="link-item dialog-focus" href="http://www.thieme-connect.com/DOI/DOI?10.1160/TH16-03-0224" target="_blank" rel="noopener" ref="linksrc=fulltextorjournal_fulltext&is_pmc=False&PrId=3400&itool=Abstract-def&log$=linkouticon&uid=27853809&db=pubmed&nlmid=7608063" title="See full text options at Georg Thieme Verlag Stuttgart, New York" data-ga-category="full_text" data-ga-action="Georg Thieme Verlag Stuttgart, New York" data-ga-label="27853809" ><img src="https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.thieme.de-classic-images-tc-logo_tcfree.jpg" alt="full text provider logo"><span class="text"> Georg Thieme Verlag Stuttgart, New York </span></a><a class="link-item pmc " href="https://pmc.ncbi.nlm.nih.gov/articles/pmid/27853809/" target="_blank" rel="noopener" ref="linksrc=fulltextorjournal_fulltext&is_pmc=True&PrId=3494&itool=Abstract-def&log$=linkouticon&uid=27853809&db=pubmed&nlmid=7608063" title="Free full text at PubMed Central" data-ga-category="full_text" data-ga-action="PMC" 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data-collections-root-url="https://www.ncbi.nlm.nih.gov/myncbi/collections/"><input type="hidden" name="csrfmiddlewaretoken" value="0nlv9T5yvJUNswVlv8gYpfQWCgpG8BsbCWBBFMkQih3CeSJdb4SinsG9z2DylZsm"><div class="choice-group" role="radiogroup"><ul class="radio-group-items"><li><input type="radio" id="collections-action-dialog-new" class="collections-new" name="collections" value="new" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_new"><label for="collections-action-dialog-new">Create a new collection</label></li><li><input type="radio" id="collections-action-dialog-existing" class="collections-existing" name="collections" value="existing" checked="true" data-ga-category="collections_button" data-ga-action="click" data-ga-label="collections_radio_existing"><label for="collections-action-dialog-existing">Add to an existing collection</label></li></ul></div><div class="controls-wrapper"><div class="action-panel-control-wrap new-collections-controls"><label for="collections-action-dialog-add-to-new" class="action-panel-label required-field-asterisk"> Name your collection: </label><input type="text" name="add-to-new-collection" id="collections-action-dialog-add-to-new" class="collections-action-add-to-new" pattern="[^"&=<>\/]*" title="The following characters are not allowed in the Name field: "&=<>/" maxlength="100" data-ga-category="collections_button" data-ga-action="create_collection" data-ga-label="non_favorties_collection"><div class="collections-new-name-too-long usa-input-error-message selection-validation-message"> Name must be less than 100 characters </div></div><div class="action-panel-control-wrap existing-collections-controls"><label for="collections-action-dialog-add-to-existing" class="action-panel-label"> Choose a collection: </label><select id="collections-action-dialog-add-to-existing" class="action-panel-selector collections-action-add-to-existing" data-ga-category="collections_button" data-ga-action="select_collection" data-ga-label="($('.collections-action-add-to-existing').val() === 'Favorites') ? 'Favorites' : 'non_favorites_collection'"></select><div class="collections-retry-load-on-error usa-input-error-message selection-validation-message"> Unable to load your collection due to an error<br><a href="#">Please try again</a></div></div></div><div class="action-panel-actions"><button class="action-panel-submit" type="submit" data-loading-label="Adding..." data-pinger-ignore data-ga-category="collections_button" data-ga-action="click" data-ga-label="add"> Add </button><button class="action-panel-cancel" aria-label="Close 'Add to Collections' panel" ref="linksrc=close_collections_panel" aria-controls="collections-action-panel" aria-expanded="false" data-ga-category="collections_button" data-ga-action="click" data-ga-label="cancel"> Cancel </button></div></form></div></div></div></div><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" 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class="article-details" id="article-details">   <header class="heading" id="heading"> <div class="full-view" id="full-view-heading"> <div class="article-citation"> <div class="publication-type" >Clinical Trial</div> <div class="article-source"> <div class="journal-actions dropdown-block"><button id="full-view-journal-trigger" class="journal-actions-trigger trigger" ref="linksrc=journal_actions_btn" title="Thrombosis and haemostasis" tabindex="0" aria-controls="full-view-journal" aria-expanded="false" aria-label="Toggle dropdown menu for journal Thrombosis and haemostasis" data-pinger-ignore> Thromb Haemost </button><div id="full-view-journal" class="journal-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for journal Thrombosis and haemostasis"><div class="title">Actions</div><div class="content"><ul class="journal-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Thromb+Haemost%22%5Bjour%5D&sort=date&sort_order=desc" data-href="/?term=%22Thromb+Haemost%22%5Bjour%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_journal_name_link&journal_abbrev=Thromb Haemost" data-ga-category="search" data-ga-action="journal_link" data-ga-label="Thromb Haemost"> Search in PubMed </a></li><li><a class="search-in-nlm-catalog-link dropdown-block-link" ref ="linksrc=search_in_nlm_catalog_link" href="https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Thromb+Haemost%22%5BTitle+Abbreviation%5D" data-ga-category="search_catalog" data-ga-action="journal_link" data-ga-label="Thromb Haemost"> Search in NLM Catalog </a></li><li><a class="add-to-search-link dropdown-block-link" ref ="linksrc=add_to_search_link" role="button" data-search-term='"Thromb Haemost"[jour]' data-ga-category="search" data-ga-action="add_to_search" data-ga-label='"Thromb Haemost"[jour]' href="#"> Add to Search </a></li></ul></div></div></div><span class="period">. </span><span class="cit">2017 Jan 26;117(2):238-245.</span> </div> <span class="citation-doi"> doi: 10.1160/TH16-03-0224. </span> <span class="secondary-date"> Epub 2016 Nov 17. </span> </div> <h1 class="heading-title"> Single-dose ciraparantag safely and completely reverses anticoagulant effects of edoxaban </h1> <div class="inline-authors"> <div class="authors"> <div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Ansell+JE&cauthor_id=27853809" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Jack E Ansell">Jack E Ansell</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Bakhru+SH&cauthor_id=27853809" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Sasha H Bakhru">Sasha H Bakhru</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Laulicht+BE&cauthor_id=27853809" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Bryan E Laulicht">Bryan E Laulicht</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Steiner+SS&cauthor_id=27853809" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Solomon S Steiner">Solomon S Steiner</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Grosso+MA&cauthor_id=27853809" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Michael A Grosso">Michael A Grosso</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Brown+K&cauthor_id=27853809" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Karen Brown">Karen Brown</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Dishy+V&cauthor_id=27853809" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Victor Dishy">Victor Dishy</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Lanz+HJ&cauthor_id=27853809" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Hans J Lanz">Hans J Lanz</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Mercuri+MF&cauthor_id=27853809" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Michele F Mercuri">Michele F Mercuri</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Noveck+RJ&cauthor_id=27853809" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Robert J Noveck">Robert J Noveck</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Costin+JC&cauthor_id=27853809" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="James C Costin">James C Costin</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="James C. Costin, MD., Perosphere, Inc. 20 Kenosia Ave, Danbury CT 06810, USA, Tel.: +1 203 885 1369, Fax: +1 215 619 0106, E-mail: j.costin@perosphere.com." href="#full-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup></span> </div> </div> </div> <div class="short-article-details"> Affiliations <button class="more-details" id="toggle-authors" data-alt-text="Collapse" aria-controls="expanded-authors" aria-expanded="false" data-pinger-ignore data-fetch-url="/27853809/long-authors/" data-id-prefix=""> <span class="title"> Expand </span> </button> </div> <div class="extended-article-details" id="expanded-authors" aria-hidden="true"> <div class="expanded-authors" id="full-view-expanded-authors"> <div class="affiliations"> <h3 class="title"> Affiliation </h3> <ul class="item-list"> <li data-affiliation-id="full-view-affiliation-1" id="full-view-affiliation-1" ><sup class="key">1</sup> James C. Costin, MD., Perosphere, Inc. 20 Kenosia Ave, Danbury CT 06810, USA, Tel.: +1 203 885 1369, Fax: +1 215 619 0106, E-mail: j.costin@perosphere.com.</li> </ul> </div> </div> </div> <ul class="identifiers" id="full-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">27853809</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=PMC6260118&id_type=PMC" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6260118/" data-ga-category="full_text" data-ga-action="PMCID" > PMC6260118 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1160/TH16-03-0224&id_type=DOI" href="https://doi.org/10.1160/th16-03-0224" data-ga-category="full_text" data-ga-action="DOI" > 10.1160/TH16-03-0224 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> <div class="short-view" id="short-view-heading"> <div class="publication-type" >Clinical Trial</div> <h1 class="heading-title"> Single-dose ciraparantag safely and completely reverses anticoagulant effects of edoxaban </h1> <div class="short-citation"> <span class="authors-list"> <span class="authors-list-item "><span class="full-name">Jack E Ansell</span><span class="citation-separator"> et al.</span></span> </span> <span class="citation-journal"> Thromb Haemost<span class="citation-separator">.</span> </span> <span class="date"> <time class="citation-year" datetime="2017">2017</time><span class="citation-separator">.</span> </span> </div> <div class="more-article-details-section with-display-settings"> <button class="more-article-details" id="toggle-article-details" data-alt-text="Hide details" ref="linksrc=toggle_article_details" aria-controls="full-article-details" aria-expanded="false" data-fetch-url="/27853809/long-authors/" data-id-prefix=""> <span class="title">Show details</span> </button> <div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"> <button class="trigger usa-button" title="Change format" data-ga-category="display_options" data-ga-action="display_options_dialog"> <span class="button-label">Display options</span> </button> <div class="dropdown" hidden> <div class="title"> Display options </div> <div class="content"> <div class="format-container"> <span class="option-label"> Format </span> <select name="format" data-initial-value="abstract" aria-label="Display format" id="mobile-display-format"> <option value="abstract">Abstract</option> <option value="pubmed">PubMed</option> <option value="pmid">PMID</option> </select> </div> </div> </div> </div> </div> <div class="extended-article-details" id="full-article-details" aria-hidden="true"> <div class="article-citation"> <div class="article-source"> <div class="journal-actions dropdown-block"><button id="short-view-journal-trigger" class="journal-actions-trigger trigger" ref="linksrc=journal_actions_btn" title="Thrombosis and haemostasis" tabindex="0" aria-controls="short-view-journal" aria-expanded="false" aria-label="Toggle dropdown menu for journal Thrombosis and haemostasis" data-pinger-ignore> Thromb Haemost </button><div id="short-view-journal" class="journal-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for journal Thrombosis and haemostasis"><div class="title">Actions</div><div class="content"><ul class="journal-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Thromb+Haemost%22%5Bjour%5D&sort=date&sort_order=desc" data-href="/?term=%22Thromb+Haemost%22%5Bjour%5D&sort=date&sort_order=desc" 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Epub 2016 Nov 17. </span> </div> <div class="expanded-authors" id="short-view-expanded-authors"> <div class="authors"> <h3 class="title"> Authors </h3> <div class="authors-list"> <span class="authors-list-item "><a class="full-name" href="/?term=Ansell+JE&cauthor_id=27853809" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Jack E Ansell">Jack E Ansell</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Bakhru+SH&cauthor_id=27853809" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Sasha H Bakhru">Sasha H Bakhru</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Laulicht+BE&cauthor_id=27853809" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Bryan E Laulicht">Bryan E Laulicht</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Steiner+SS&cauthor_id=27853809" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Solomon S Steiner">Solomon S Steiner</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Grosso+MA&cauthor_id=27853809" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Michael A Grosso">Michael A Grosso</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Brown+K&cauthor_id=27853809" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Karen Brown">Karen Brown</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Dishy+V&cauthor_id=27853809" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Victor Dishy">Victor Dishy</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Lanz+HJ&cauthor_id=27853809" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Hans J Lanz">Hans J Lanz</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Mercuri+MF&cauthor_id=27853809" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Michele F Mercuri">Michele F Mercuri</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Noveck+RJ&cauthor_id=27853809" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="Robert J Noveck">Robert J Noveck</a><span class="comma">, </span></span><span class="authors-list-item "><a class="full-name" href="/?term=Costin+JC&cauthor_id=27853809" ref="linksrc=author_name_link" data-ga-category="search" data-ga-action="author_link" data-ga-label="James C Costin">James C Costin</a><sup class="affiliation-links"><span class="author-sup-separator"> </span><a class="affiliation-link" title="James C. Costin, MD., Perosphere, Inc. 20 Kenosia Ave, Danbury CT 06810, USA, Tel.: +1 203 885 1369, Fax: +1 215 619 0106, E-mail: j.costin@perosphere.com." href="#short-view-affiliation-1" ref="linksrc=author_aff"> 1 </a></sup></span> </div> </div> <div class="affiliations"> <h3 class="title"> Affiliation </h3> <ul class="item-list"> <li data-affiliation-id="short-view-affiliation-1" id="short-view-affiliation-1" ><sup class="key">1</sup> James C. Costin, MD., Perosphere, Inc. 20 Kenosia Ave, Danbury CT 06810, USA, Tel.: +1 203 885 1369, Fax: +1 215 619 0106, E-mail: j.costin@perosphere.com.</li> </ul> </div> </div> <ul class="identifiers" id="short-view-identifiers"> <li> <span class="identifier pubmed"> <span class="id-label"> PMID: </span> <strong class="current-id" title="PubMed ID">27853809</strong> </span> </li> <li> <span class="identifier pmc"> <span class="id-label"> PMCID: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=PMC6260118&id_type=PMC" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6260118/" data-ga-category="full_text" data-ga-action="PMCID" > PMC6260118 </a> </span> </li> <li> <span class="identifier doi"> <span class="id-label"> DOI: </span> <a class="id-link" target="_blank" rel="noopener" ref="linksrc=article_id_link&article_id=10.1160/TH16-03-0224&id_type=DOI" href="https://doi.org/10.1160/th16-03-0224" data-ga-category="full_text" data-ga-action="DOI" > 10.1160/TH16-03-0224 </a> </span> </li> </ul> <div class="in-clipboard-label " hidden> Item in Clipboard </div> </div> </div> </header> <div class="actions-buttons inline"><div class="inner-wrap"><button class="full-text-links-button full-text-links-dialog-trigger" title="Open dialog with full text links" ref="linksrc=full_text_links"> Full text links </button><button class="citation-button citation-dialog-trigger" aria-label="Open dialog with citation text in different styles" data-ga-category="save_share" data-ga-action="cite" data-ga-label="open" data-all-citations-url="/27853809/citations/" data-citation-style="nlm" data-pubmed-format-link="/27853809/export/"><span class="button-label">Cite</span></button><button class="more-actions-button more-actions-dialog-trigger" title="Open dialog with more actions to take" ref="linksrc=more_actions_btn"></button><div class="display-options" data-format-key="format" data-default-format-value="abstract" data-current-format-value="abstract" role="region"><button class="trigger usa-button" title="Change format" data-ga-category="display_options" data-ga-action="display_options_dialog"><span class="button-label">Display options</span></button><div class="dropdown" hidden><div class="title"> Display options </div><div class="content"><div class="format-container"><span class="option-label"> Format </span><select name="format" data-initial-value="abstract" aria-label="Display format" id="inline-actions-display-format"><option value="abstract">Abstract</option><option value="pubmed">PubMed</option><option value="pmid">PMID</option></select></div></div></div></div></div></div> <div class="abstract" id="abstract"> <h2 class="title"> Abstract </h2> <div class="abstract-content selected" id="eng-abstract"> <p> Of the new direct oral anticoagulants, direct factor Xa inhibitors are limited by the absence of a proven reversal agent. We assessed the safety, tolerability and impact on anticoagulation reversal of ciraparantag (PER977) alone and following a 60 mg dose of the FXa inhibitor edoxaban. Escalating, single IV doses of ciraparantag were administered alone and following a 60 mg oral dose of edoxaban in a double-blind, placebo-controlled fashion to healthy subjects. Serial assessments of the pharmacokinetics and pharmacodynamic effects of ciraparantag were performed. Eighty male subjects completed the study. Following edoxaban (60 mg), a single IV dose of ciraparantag (100 to 300 mg) demonstrated full reversal of anticoagulation within 10 minutes and sustained for 24 hours. Fibrin diameter within clots was restored to normal 30 minutes after a single dose of 100 to 300 mg ciraparantag as determined by scanning electron microscopy and change in fibrin diameter quantified by automated image analysis. Potentially related adverse events were periorbital and facial flushing and cool sensation following IV injection of ciraparantag. Renal excretion of ciraparantag metabolite was the main elimination route. There was no evidence of procoagulant activity following ciraparantag as assessed by D-dimer, prothrombin fragments 1.2, and tissue factor pathway inhibitor levels. In conclusion, ciraparantag in healthy subjects is safe and well tolerated with minor, non-dose limiting adverse events. Baseline haemostasis was restored from the anticoagulated state with doses of 100 to 300 mg ciraparantag within 10-30 minutes of administration and sustained for at least 24 hours. </p> </div> <p> <strong class="sub-title"> Trial registration: </strong> ClinicalTrials.gov <a href="http://clinicaltrials.gov/show/NCT01826266" title="See in ClinicalTrials.gov">NCT01826266</a>. </p> <p> <strong class="sub-title"> Keywords: </strong> Ciraparantag; anticoagulant; edoxaban; reversal; whole blood clotting time. </p> </div> <p class="disclaimer" id="disclaimer"> <a href="/disclaimer/" target="_blank" ga_category="literature_resources" ga_action="disclaimer_link" ga_label="under_abstract">PubMed Disclaimer</a> </p> <div class="conflict-of-interest" id="conflict-of-interest"> <h2 class="title"> Conflict of interest statement </h2> <div class="statement"> <p xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:p1="http://pubmed.gov/pub-one"><bold>Conflicts of interest</bold> Dr. Ansell is a consultant to Perosphere, Inc. Drs. Bakhru, Costin, Laulicht, and Steiner are employees of Perosphere, Inc. Drs. Lanz, Mercuri, Grosso and Dishy are employees of Daiichi-Sankyo Pharma Development, the co-sponsor of this study. Dr. Brown was an employee of Daiichi Sankyo Pharma Development at the time this work was performed. Dr. Noveck is an employee of Duke Clinical Research Unit, the clinical research organization which conducted the study.</p> </div> </div> <div class="figures" id="figures"> <h2 class="title"> Figures </h2> <div class="figures-list" id="slides-container" itemscope itemtype="http://schema.org/ImageGallery"> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="0" data-label-slug="figure-1-study-design"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cc3/6260118/431b7427b90d/im_10-1160-th16-03-0224-i1.jpg" itemprop="contentUrl" aria-describedby="figure-caption-0" role="button" data-image-width="516" data-image-height="470" data-image-alt="Figure 1: Study design" data-pmc-id="PMC6260118" data-figure-id="FI0224-1"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-0" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cc3/6260118/089b9b66e98d/im_10-1160-th16-03-0224-i1.gif" alt="Figure 1: Study design" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="516"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="470"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 1: Study design </p> </strong> <div class="figure-caption-contents"><p> . All cohorts:… </p></div> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 1: Study design </p> </strong> <div class="figure-caption-contents"><p> . All cohorts: n=10 (8 active + 2 placebo); 7 days… </p></div> </div> <figcaption id="figure-caption-0" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 1: Study design </strong> <div class="figure-caption-contents">. All cohorts: n=10 (8 active + 2 placebo); 7 days between patient dosing within a cohort and 3 days between cohorts; in Period 2, ciraparantag or placebo administered approximately 3 h post edoxaban (EDX). The 25 mg dosing cohort was repeated using the WBCT to achieve a total of eight dosing cohorts.</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="1" data-label-slug="figure-2-correlation-of-wbct-after-a-60-mg-dose-of-edoxaban-a-and-lack-of-effect-of-ciraparantag-administration-on-wbct-b"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cc3/6260118/c38ab570e2ba/im_10-1160-th16-03-0224-i2.jpg" itemprop="contentUrl" aria-describedby="figure-caption-1" role="button" data-image-width="515" data-image-height="536" data-image-alt="Figure 2: Correlation of WBCT after a 60 mg dose of edoxaban (A) and lack of effect of ciraparantag administration on WBCT (B)." data-pmc-id="PMC6260118" data-figure-id="FI0224-2"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-1" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cc3/6260118/ee3881a95497/im_10-1160-th16-03-0224-i2.gif" alt="Figure 2: Correlation of WBCT after a 60 mg dose of edoxaban (A) and lack of effect of ciraparantag administration on WBCT (B)." /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="515"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="536"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 2: Correlation of WBCT after a… </p> </strong> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 2: Correlation of WBCT after a 60 mg dose of edoxaban (A) and lack… </p> </strong> </div> <figcaption id="figure-caption-1" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 2: Correlation of WBCT after a 60 mg dose of edoxaban (A) and lack of effect of ciraparantag administration on WBCT (B). </strong> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="2" data-label-slug="figure-3-mean-wbct-following-a-single-iv-dose-of-25-100-and-300-mg-ciraparantag-versus-pooled-saline-placebo"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cc3/6260118/f8d5f58712fb/im_10-1160-th16-03-0224-i3.jpg" itemprop="contentUrl" aria-describedby="figure-caption-2" role="button" data-image-width="516" data-image-height="394" data-image-alt="Figure 3: Mean WBCT following a single i.v. dose of 25, 100, and 300 mg ciraparantag versus pooled saline placebo" data-pmc-id="PMC6260118" data-figure-id="FI0224-3"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-2" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cc3/6260118/0fdca98984d7/im_10-1160-th16-03-0224-i3.gif" alt="Figure 3: Mean WBCT following a single i.v. dose of 25, 100, and 300 mg ciraparantag versus pooled saline placebo" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="516"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="394"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 3: Mean WBCT following a single… </p> </strong> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 3: Mean WBCT following a single i.v. dose of 25, 100, and 300 mg… </p> </strong> </div> <figcaption id="figure-caption-2" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 3: Mean WBCT following a single i.v. dose of 25, 100, and 300 mg ciraparantag versus pooled saline placebo </strong> <div class="figure-caption-contents">. Data in subjects administered a single oral dose of edoxaban 60 mg (see Suppl. Table 2 for statistical assessment of differences, available online at <ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://www.thrombosis-online.com">www.thrombosis-online.com</ext-link> ).</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="3" data-label-slug="figure-4-visual-examination-of-blood-clots-from-wbct-assay-pre-and-post-ciraparantag-versus-saline"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cc3/6260118/19019d602a41/im_10-1160-th16-03-0224-i4.jpg" itemprop="contentUrl" aria-describedby="figure-caption-3" role="button" data-image-width="780" data-image-height="653" data-image-alt="Figure 4: Visual examination of blood clots from WBCT assay pre-and post- ciraparantag versus saline" data-pmc-id="PMC6260118" data-figure-id="FI0224-4"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-3" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cc3/6260118/47a65bade827/im_10-1160-th16-03-0224-i4.gif" alt="Figure 4: Visual examination of blood clots from WBCT assay pre-and post- ciraparantag versus saline" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="780"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="653"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 4: Visual examination of blood clots… </p> </strong> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 4: Visual examination of blood clots from WBCT assay pre-and post- ciraparantag versus saline </p> </strong> </div> <figcaption id="figure-caption-3" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 4: Visual examination of blood clots from WBCT assay pre-and post- ciraparantag versus saline </strong> <div class="figure-caption-contents">. Scale bar: 1 inch (A) and clot fibrin structure pre- and post- ciraparantag (B) (upper and lower photos represent lower and higher magnification. Computer algorithm-based quantification of clot fibrin diameter showed a significant difference between saline vs native fibrin (p<0.001); between ciraparantag 25 mg vs native fibrin (p<0.01); and between ciraparantag 25 mg vs ciraparantag 300 mg (p<0.05).</div> </figcaption> </figure> <figure class="figure-item " itemscope itemtype="http://schema.org/ImageObject" itemprop="associatedMedia" data-slide-index="4" data-label-slug="figure-5-ciraparantag-effect-on-d-dimer-prothrombin-fragment-f12-and-tissue-factor-pathway-inhibitor-tfpi"> <a class="figure-link" href="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cc3/6260118/88cf4765ee24/im_10-1160-th16-03-0224-i5.jpg" itemprop="contentUrl" aria-describedby="figure-caption-4" role="button" data-image-width="516" data-image-height="793" data-image-alt="Figure 5: Ciraparantag effect on D-dimer, prothrombin fragment F1.2 and tissue factor pathway inhibitor (TFPI)" data-pmc-id="PMC6260118" data-figure-id="FI0224-5"> <img class="figure-thumb" itemprop="thumbnail" id="article-image-4" src="https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cc3/6260118/8c1f7cae2bc7/im_10-1160-th16-03-0224-i5.gif" alt="Figure 5: Ciraparantag effect on D-dimer, prothrombin fragment F1.2 and tissue factor pathway inhibitor (TFPI)" /> </a> <meta itemprop="width" itemtype="http://schema.org/ImageObject" content="516"> <meta itemprop="height" itemtype="http://schema.org/ImageObject" content="793"> <div class="figure-caption figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="caption" aria-hidden="true"> <div class="caption-wrap"> <strong class="figure-label"> <p> Figure 5: Ciraparantag effect on D-dimer, prothrombin… </p> </strong> </div> </div> <div class="figure-caption-medium figure-caption-text" aria-hidden="true"> <strong class="figure-label"> <p> Figure 5: Ciraparantag effect on D-dimer, prothrombin fragment F1.2 and tissue factor pathway inhibitor (TFPI) </p> </strong> </div> <figcaption id="figure-caption-4" class="figure-caption-full figure-caption-text" itemtype="http://schema.org/ImageObject" itemprop="description"> <strong class="figure-label"> Figure 5: Ciraparantag effect on D-dimer, prothrombin fragment F1.2 and tissue factor pathway inhibitor (TFPI) </strong> <div class="figure-caption-contents">. Lower doses of ciraparantag (PER977) are deleted from panel C to make it visually more clear.</div> </figcaption> </figure> </div>  <div class="pswp figures-dialog" id="figures-dialog" tabindex="-1" role="dialog" aria-hidden="true" data-image-gallery-uid="article-figures" aria-label="Figures Dialog">  <div class="pswp__bg"></div>  <div class="pswp__scroll-wrap">  <div class="pswp__container"> <div class="pswp__item"></div> <div class="pswp__item"></div> <div class="pswp__item"></div> </div>  <div class="pswp__ui pswp__ui--hidden"> <div class="pswp__top-bar">  <div class="pswp__counter"></div> <button class="pswp__button pswp__button--close" title="Close (Esc)"></button> <button class="pswp__button pswp__button--share" title="Share"></button> <button class="pswp__button pswp__button--fs" title="Toggle fullscreen"></button> <button class="pswp__button pswp__button--zoom" title="Zoom in/out"></button>   <div class="pswp__preloader"> <div class="pswp__preloader__icn"> <div class="pswp__preloader__cut"> <div class="pswp__preloader__donut"></div> </div> </div> </div> </div> <div class="pswp__share-modal pswp__share-modal--hidden pswp__single-tap"> <div class="pswp__share-tooltip"></div> </div> <button class="pswp__button pswp__button--arrow--left" title="Previous (arrow left)"> </button> <button class="pswp__button pswp__button--arrow--right" title="Next (arrow right)"> </button> <div class="pswp__caption"> <div class="pswp__caption__center"></div> </div> </div> </div> </div> <div class="figure-dialog-caption"> <div class="figure-caption-link-container"> <a class="figure-caption-link" href="#">See this image and copyright information in PMC</a> </div> <div class="figure-caption-center" data-expand-title="click to show full caption" data-collapse-title="click to hide full caption"> </div> <button class="figure-caption-toggle-btn" aria-label="show full caption" data-expand-text="show full caption" data-collapse-text="hide full caption">  </button> </div> </div> <div class="similar-articles" id="similar"> <h2 class="title"> Similar articles </h2> <ul class="articles-list" id="similar-articles-list"> <li class="full-docsum"> <div class="docsum-content" style="display:inline;"> <a class="docsum-title" href="/27470323/" ref="article_id=27470323&linksrc=similar_articles_link&ordinalpos=1" data-ga-category="similar_article" data-ga-action="27470323" data-ga-label=""> Ciraparantag safely and completely reverses the anticoagulant effects of low molecular weight heparin. </a> <div class="docsum-citation full-citation"> <span class="docsum-authors full-authors">Ansell JE, Laulicht BE, Bakhru SH, Hoffman M, Steiner SS, Costin JC.</span> <span class="docsum-authors short-authors">Ansell JE, et al.</span> <span class="docsum-journal-citation full-journal-citation">Thromb Res. 2016 Oct;146:113-118. doi: 10.1016/j.thromres.2016.07.008. 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</div> <div id="mesh-terms" class="mesh-terms keywords-section"> <h2 class="title"> MeSH terms </h2> <ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Administration, Oral" tabindex="0" aria-controls="keyword-actions-mesh-terms-0" aria-expanded="false" data-pinger-ignore> Administration, Oral </button><div id="keyword-actions-mesh-terms-0" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Administration, Oral"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Administration%2C+Oral%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Administration%2C+Oral%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Administration, Oral"[MeSH]" 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pharmacokinetics" tabindex="0" aria-controls="keyword-actions-mesh-terms-17" aria-expanded="false" data-pinger-ignore> Piperazines / pharmacokinetics </button><div id="keyword-actions-mesh-terms-17" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Piperazines / pharmacokinetics"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Piperazines%2Fpharmacokinetics%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Piperazines%2Fpharmacokinetics%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Piperazines/pharmacokinetics"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Piperazines / pharmacokinetics"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" 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ref="linksrc=add_to_search_link" role="button" data-search-term=""Pyridines/administration and dosage"[MAJR]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Pyridines/administration and dosage"[MAJR]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Pyridines / adverse effects" tabindex="0" aria-controls="keyword-actions-mesh-terms-19" aria-expanded="false" data-pinger-ignore> Pyridines / adverse effects </button><div id="keyword-actions-mesh-terms-19" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Pyridines / adverse effects"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Pyridines%2Fadverse+effects%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Pyridines%2Fadverse+effects%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Pyridines/adverse effects"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Pyridines / adverse effects"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Pyridines" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Pyridines / adverse effects"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Pyridines/adverse effects"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Pyridines/adverse effects"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link major" aria-label="Toggle dropdown menu for keyword Thiazoles / administration & dosage*" tabindex="0" aria-controls="keyword-actions-mesh-terms-major-20" aria-expanded="false" data-pinger-ignore> Thiazoles / administration & dosage* </button><div id="keyword-actions-mesh-terms-major-20" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Thiazoles / administration & dosage*"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Thiazoles%2Fadministration+and+dosage%22%5BMAJR%5D&sort=date&sort_order=desc" data-href="/?term=%22Thiazoles%2Fadministration+and+dosage%22%5BMAJR%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Thiazoles/administration and dosage"[MAJR]" data-ga-category="search" 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effects"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Thiazoles/adverse effects"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Thiazoles/adverse effects"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Whole Blood Coagulation Time" tabindex="0" aria-controls="keyword-actions-mesh-terms-22" aria-expanded="false" data-pinger-ignore> Whole Blood Coagulation Time </button><div id="keyword-actions-mesh-terms-22" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Whole Blood Coagulation Time"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Whole+Blood+Coagulation+Time%22%5BMeSH%5D&sort=date&sort_order=desc" data-href="/?term=%22Whole+Blood+Coagulation+Time%22%5BMeSH%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&mesh="Whole Blood Coagulation Time"[MeSH]" data-ga-category="search" data-ga-action="mesh_term" data-ga-label="Whole Blood Coagulation Time"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=Whole+Blood+Coagulation+Time" data-ga-category="search_mesh" data-ga-action="mesh_term_link" data-ga-label="Whole Blood Coagulation Time"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Whole Blood Coagulation Time"[MeSH]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Whole Blood Coagulation Time"[MeSH]" href="#"> Add to Search </a></li></ul></div></div></div></li></ul> </div> <div id="substances" class="substances keywords-section"> <h2 class="title"> Substances </h2> <ul class="keywords-list"><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Factor Xa Inhibitors" tabindex="0" aria-controls="keyword-actions-substances-0" aria-expanded="false" data-pinger-ignore> Factor Xa Inhibitors </button><div id="keyword-actions-substances-0" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Factor Xa Inhibitors"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Factor+Xa+Inhibitors%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Factor+Xa+Inhibitors%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Factor Xa Inhibitors"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Factor Xa Inhibitors"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Factor+Xa+Inhibitors%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="Factor Xa Inhibitors"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Factor Xa Inhibitors"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Factor Xa Inhibitors"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Piperazines" tabindex="0" aria-controls="keyword-actions-substances-1" aria-expanded="false" data-pinger-ignore> Piperazines </button><div id="keyword-actions-substances-1" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Piperazines"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Piperazines%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Piperazines%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Piperazines"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Piperazines"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Piperazines%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="Piperazines"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Piperazines"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Piperazines"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Pyridines" tabindex="0" aria-controls="keyword-actions-substances-2" aria-expanded="false" data-pinger-ignore> Pyridines </button><div id="keyword-actions-substances-2" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Pyridines"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Pyridines%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Pyridines%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Pyridines"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Pyridines"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Pyridines%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="Pyridines"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Pyridines"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Pyridines"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Thiazoles" tabindex="0" aria-controls="keyword-actions-substances-3" aria-expanded="false" data-pinger-ignore> Thiazoles </button><div id="keyword-actions-substances-3" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Thiazoles"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Thiazoles%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Thiazoles%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Thiazoles"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Thiazoles"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22Thiazoles%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="Thiazoles"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""Thiazoles"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""Thiazoles"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword Arginine" tabindex="0" aria-controls="keyword-actions-substances-4" aria-expanded="false" data-pinger-ignore> Arginine </button><div id="keyword-actions-substances-4" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword Arginine"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22Arginine%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22Arginine%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="Arginine"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="Arginine"> Search in PubMed 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class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22edoxaban%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22edoxaban%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="edoxaban"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="edoxaban"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22edoxaban%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="edoxaban"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""edoxaban"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""edoxaban"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li><li><div class="keyword-actions dropdown-block"><button class="keyword-actions-trigger trigger keyword-link" aria-label="Toggle dropdown menu for keyword PER977" tabindex="0" aria-controls="keyword-actions-substances-6" aria-expanded="false" data-pinger-ignore> PER977 </button><div id="keyword-actions-substances-6" class="keyword-actions-dropdown dropdown dropdown-container" hidden aria-label="Dropdown menu for keyword PER977"><div class="title">Actions</div><div class="content"><ul class="keyword-actions-links"><li><a class="search-in-pubmed-link dropdown-block-link" href="/?term=%22PER977%22%5Bnm%5D&sort=date&sort_order=desc" data-href="/?term=%22PER977%22%5Bnm%5D&sort=date&sort_order=desc" ref="linksrc=search_in_pubmed_keyword_link&keyword="PER977"[nm]" data-ga-category="search" data-ga-action="substance" data-ga-label="PER977"> Search in PubMed </a></li><li><a class="search-in-mesh-link dropdown-block-link" ref="linksrc=search_in_mesh_link" href="https://www.ncbi.nlm.nih.gov/mesh?term=%22PER977%22" data-ga-category="search_mesh" data-ga-action="substance_link" data-ga-label="PER977"> Search in MeSH </a></li><li><a class="add-to-search-link dropdown-block-link" ref="linksrc=add_to_search_link" role="button" data-search-term=""PER977"[nm]" data-ga-category="search" data-ga-action="add_to_search" data-ga-label=""PER977"[nm]" href="#"> Add to Search </a></li></ul></div></div></div></li></ul> </div> <div id="supplemental-data" class="supplemental-data"> <h2 class="title"> Associated data </h2> <ul class="supplemental-data-list"><li><div class="supplemental-data-actions dropdown-block"><button class="supplemental-data-actions-trigger trigger" title="Supplemental Data Dropdown Toggle" ref="linksrc=supplemental_data_actions_btn" tabindex="0" aria-controls="supplemental-data-ClinicalTrials.gov-NCT01826266" aria-describedby="supplemental-data-ClinicalTrials.gov-NCT01826266" data-pinger-ignore> ClinicalTrials.gov/NCT01826266 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Compound via MeSH" href="https://www.ncbi.nlm.nih.gov/pccompound?linkname=pubmed_pccompound_mesh&from_uid=27853809" ref="log$=recordlinks&logdbfrom=pubmed&ncbi_uid=27853809&ordinalpos=1&linkpos=1"> PubChem Compound (MeSH Keyword) </a></li></ul> </div> <div id="grants" class="grants"> <h2 class="title"> Grants and funding </h2> <div class="grants-list"></div><div class="funding-statement"><bold>Financial support:</bold> This study was funded by Peropshere, Inc. 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