CINXE.COM

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content="Proteins for Stem Cell Culture" class="rdf-meta element-hidden"></span><span property="sioc:num_replies" content="0" datatype="xsd:integer" class="rdf-meta element-hidden"></span> </header> <div class="field field-name-body field-type-text-with-summary field-label-hidden"><div class="field-items"><div class="field-item even" property="content:encoded"><meta name="viewport" content="width=device-width, initial-scale=1"> <style type="text/css">body {font-family: Arial;} /* Style the tab */ .tab { overflow: hidden; } /* Style the buttons inside the tab */ .tab button { background-color: inherit; text-align: left; width: 100%; border: none; outline: none; cursor: pointer; padding: 14px 16px; transition: 0.3s; font-size: 14px; } /* Change background color of buttons on hover */ .tab button:hover { background-color: #005f9e; color: aliceblue; } /* Create an active/current tablink class */ .tab button.active { background-color: #ccc; } /* Style the tab content */ .tabcontent { 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class="col-xs-12"> <p><img alt="Proteins for Stem Cell Culture Banner" src="//resources.rndsystems.com/images/design/stem-cell-landing-rnd_hero-banner3.png" width="1200px" /></p> </div> </div> </div> <div class="row"> <div class="padded_row" style="margin: 30px 0px"> <div class="col-xs-12"> <h2>Optimize Your Stem Cell Cultures with R&D Systems™ Proteins</h2> <p>Pluripotent stem cells have the ability to self-renew and differentiate into any cell type in the human body, making them powerful tools for exploring human development, modeling diseases, screening drugs, and developing novel therapies to treat genetic diseases or repair damaged tissues. Bio-Techne offers a comprehensive selection of R&D Systems cytokines and growth factors for culturing stem cells. Our proteins are rigorously tested to ensure that they provide high levels of bioactivity and lot-to-lot consistency so you can be confident that they will promote robust, reproducible stem cell expansion and differentiation. From basic research to clinical manufacturing, we offer research-grade, Animal-free, and GMP-grade proteins to meet all your research needs.</p> </div> </div> </div> <div id="icons" name="icon menu"> <div class="row icon-menu" style="margin: 30px 0px"> <div class="col-md-2 col-sm-4 col-xs-6 text-center"> <div class="card"><a href="#pluripotent"><img alt="pluripotent stem cell icon" class="img-responsive center-block" loading="lazy" src="//resources.rndsystems.com/images/design/stem-cell-landing-rnd_Pluripotent-icon8.png" /></a> <div class="group-title-wrapper"> <p style="margin-top: 5px"><a href="#pluripotent"><strong>Pluripotent Stem<br /> Cells</strong></a></p> </div> </div> </div> <div class="col-md-2 col-sm-4 col-xs-6 text-center"> <div class="card"><a href="#neural"><img alt="neural stem cell icon" class="img-responsive center-block" loading="lazy" src="//resources.rndsystems.com/images/design/stem-cell-landing-rnd_neural-icon8.png" /></a> <div class="group-title-wrapper"> <p style="margin-top: 5px"><a href="#neural"><strong>Neural Stem<br /> Cells</strong></a></p> </div> </div> </div> <div class="col-md-2 col-sm-4 col-xs-6 text-center"> <div class="card"><a href="#mesenchymal"><img alt="mesenchymal stem cell icon" class="img-responsive center-block" loading="lazy" src="//resources.rndsystems.com/images/design/stem-cell-landing-rnd_mesenchymal-icon8.png" /></a> <div class="group-title-wrapper"> <p style="margin-top: 5px"><a href="#mesenchymal"><strong>Mesenchymal<br /> Stem Cells</strong></a></p> </div> </div> </div> <div class="col-md-2 col-sm-4 col-xs-6 text-center"> <div class="card"><a href="#hematopoietic"><img alt="hematopoietic stem cell icon" class="img-responsive center-block" loading="lazy" src="//resources.rndsystems.com/images/design/stem-cell-landing-rnd_hematopoietic-icon8.png" /></a> <div class="group-title-wrapper"> <p style="margin-top: 5px"><a href="#hematopoietic"><strong>Hematopoietic<br /> Stem Cells</strong></a></p> </div> </div> </div> <div class="col-md-2 col-sm-4 col-xs-6 text-center"> <div class="card"><a href="/products/organoid-and-3d-culture-reagents"><img alt="organoid and 3-D cell culture icon" class="img-responsive center-block" loading="lazy" src="//resources.rndsystems.com/images/design/stem-cell-landing-rnd_organoid-icon8.png" /></a> <div class="group-title-wrapper"> <p style="margin-top: 5px"><a href="/products/organoid-and-3d-culture-reagents"><strong>Organoid and<br /> 3-D Cell Culture</strong></a></p> </div> </div> </div> <div class="col-md-2 col-sm-4 col-xs-6 text-center"> <div class="card"><a href="#resources"><img alt="other stem cell-related resources icon" class="img-responsive center-block" loading="lazy" src="//resources.rndsystems.com/images/design/stem-cell-landing-rnd_other-icon8.png" /></a> <div class="group-title-wrapper"> <p style="margin-top: 5px"><a href="#resources"><strong>Other Stem Cell<br /> Related Resources</strong></a></p> </div> </div> </div> </div> </div> <p> </p> <div class="row"> <div class="padded_row"> <div class="col-xs-7"> <p> </p> <h2 style="line-height: auto;">From Your Peers: Stem Cell Core Facility Directors Explain Why They Choose R&D Systems Cytokines for their Research</h2> <p>Multiple stem cell core facility directors describe their experiences using R&D Systems cytokines and growth factors. Learn why they prefer R&D Systems products for their research. The speakers on the video include Sunita D’Souza, Director of the Center for Modern Pediatric Diseases at St. Jude’s Medical Center; Deborah French, Director of the Human Pluripotent Stem Cell Core at the Children’s Hospital of Philadelphia; Barbara Corneo, Director of the Stem Cell Core Facility at Columbia University Medical School; and Wenli Yang, Director of the iPSC Core Facility at the University of Pennsylvania.</p> </div> <div class="col-xs-5"> <div class="youtube-player"><iframe src="https://www.youtube.com/embed/IUydCoe0yvQ"></iframe></div> </div> </div> </div> <p> </p> <div class="row"> <div class="padded_row"> <div class="col-xs-12" id="pluripotent"> <h2 style="margin-top: 30px">Pluripotent Stem Cells</h2> <p>Pluripotent stem cells are capable of long-term self-renewal and have the potential to differentiate into cell types of the endoderm, mesoderm, or ectoderm. Both embryonic stem cells (ESCs) isolated from the inner cell mass of a blastocyst and induced pluripotent stem cells (iPSCs) produced by reprogramming adult somatic cells into an embryonic-like pluripotent state are collectively called pluripotent stem cells. The discovery that somatic cells could be reprogrammed into iPSCs has provided a potentially limitless supply of stem cells for regenerative medicine, novel therapeutic approaches for repairing damaged tissues, and the possibility of patient-specific cell therapies, while bypassing the ethical issues associated with the use of ESCs.</p> <div class="ultrex_table_wrapper"> <table cellpadding="8" cellspacing="0" class="table table-bordered table-stripped" width="100%"> <tbody> <tr> <td class="info" colspan="6"><strong>Cytokines for ESC and iPSC Expansion</strong></td> </tr> <tr> <td><a href="/target/activin-a?category=Proteins%20and%20Enzymes">Activin A</a>*</td> <td><a href="/target/bmp-4?category=Proteins%20and%20Enzymes">BMP-4</a>*</td> <td><a href="/target/fgf-basic-fgf2-bfgf?category=Proteins%20and%20Enzymes">FGF basic/FGF2</a>*</td> <td><a href="/target/nodal?category=Proteins%20and%20Enzymes">Nodal</a></td> <td><a href="/target/tgf-beta-1?category=Proteins%20and%20Enzymes">TGF-beta 1</a>*</td> <td><a href="/target/wnt-3a?category=Proteins%20and%20Enzymes">Wnt-3a*</a></td> </tr> </tbody> </table> </div> <div class="ultrex_table_wrapper"> <table cellpadding="8" cellspacing="0" class="table table-bordered table-stripped" width="100%"> <tbody> <tr> <td class="info" colspan="4"><strong>Cytokines for Ectoderm Lineage Differentiation</strong></td> </tr> <tr> <td><a href="/target/bmp-4?category=Proteins%20and%20Enzymes">BMP-4</a>*</td> <td><a href="/target/egf?category=Proteins%20and%20Enzymes">EGF</a>*</td> <td><a href="/target/fgf-basic-fgf2-bfgf?category=Proteins%20and%20Enzymes">FGF basic/FGF2</a>*</td> <td><a href="/target/noggin?category=Proteins%20and%20Enzymes">Noggin</a>*</td> </tr> </tbody> </table> </div> <div class="ultrex_table_wrapper"> <table cellpadding="8" cellspacing="0" class="table table-bordered table-stripped" width="100%"> <tbody> <tr> <td class="info" colspan="5"><strong>Cytokines for Mesoderm Lineage Differentiation</strong></td> </tr> <tr> <td><a href="/target/activin-a?category=Proteins%20and%20Enzymes">Activin A</a>*</td> <td><a href="/target/bmp-2?category=Proteins%20and%20Enzymes">BMP-2</a>*</td> <td><a href="/target/bmp-4?category=Proteins%20and%20Enzymes">BMP-4</a>*</td> <td><a href="/target/dkk-1?category=Proteins%20and%20Enzymes">Dkk-1</a></td> <td><a href="/target/fgf-basic-fgf2-bfgf?category=Proteins%20and%20Enzymes">FGF basic/FGF2</a>*</td> </tr> <tr> <td><a href="/target/fgf-3?category=Proteins%20and%20Enzymes">FGF-3</a></td> <td><a href="/target/fgf-10?category=Proteins%20and%20Enzymes">FGF-10</a></td> <td><a href="/target/fgf-17?category=Proteins%20and%20Enzymes">FGF-17</a></td> <td><a href="/target/flt-3-ligand-flt3l?category=Proteins%20and%20Enzymes">Flt-3 Ligand/FLT3L</a>*</td> <td><a href="/target/il-3?category=Proteins%20and%20Enzymes">IL-3</a>*</td> </tr> <tr> <td><a href="/target/il-6?category=Proteins%20and%20Enzymes">IL-6</a>*</td> <td><a href="/target/il-11?category=Proteins%20and%20Enzymes">IL-11</a></td> <td><a href="/target/noggin?category=Proteins%20and%20Enzymes">Noggin</a>*</td> <td><a href="/target/pdgf-bb?category=Proteins%20and%20Enzymes">PDGF-BB</a>*</td> <td><a href="/target/scf-c-kit-ligand?category=Proteins%20and%20Enzymes">SCF/c-kit Ligand</a>*</td> </tr> <tr> <td><a href="/target/tgf-beta-1?category=Proteins%20and%20Enzymes">TGF-beta 1</a>*</td> <td><a href="/target/thrombopoietin-tpo?category=Proteins%20and%20Enzymes">Thrombopoietin/TPO</a>*</td> <td><a href="/target/vegf?category=Proteins%20and%20Enzymes">VEGF</a>*</td> <td><a href="/target/wnt-5a?category=Proteins%20and%20Enzymes">Wnt-5a</a></td> <td> </td> </tr> </tbody> </table> </div> <div class="ultrex_table_wrapper"> <table cellpadding="8" cellspacing="0" class="table table-bordered table-stripped" width="100%"> <tbody> <tr> <td class="info" colspan="5"><strong>Cytokines for Endoderm Lineage Differentiation</strong></td> </tr> <tr> <td><a href="/target/activin-a?category=Proteins%20and%20Enzymes">Activin A</a>*</td> <td><a href="/target/bmp-4?category=Proteins%20and%20Enzymes">BMP-4</a>*</td> <td><a href="/target/egf?category=Proteins%20and%20Enzymes">EGF</a>*</td> <td><a href="/target/fgf-basic-fgf2-bfgf?category=Proteins%20and%20Enzymes">FGF basic/FGF2</a>*</td> <td><a href="/target/fgf-4?category=Proteins%20and%20Enzymes">FGF-4</a></td> </tr> <tr> <td><a href="/target/kgf-fgf-7?category=Proteins%20and%20Enzymes">FGF-7/KGF</a>*</td> <td><a href="/target/fgf-10?category=Proteins%20and%20Enzymes">FGF-10</a></td> <td><a href="/target/fgf-18?category=Proteins%20and%20Enzymes">FGF-18</a></td> <td><a href="/target/hgf?category=Proteins%20and%20Enzymes">HGF</a>*</td> <td><a href="/target/igf-i-igf-1?category=Proteins%20and%20Enzymes">IGF-I/IGF-1</a>*</td> </tr> <tr> <td><a href="/target/noggin?category=Proteins%20and%20Enzymes">Noggin</a>*</td> <td><a href="/target/pdgf-bb?category=Proteins%20and%20Enzymes">PDGF-BB</a>*</td> <td><a href="/target/sonic-hedgehog-shh?category=Proteins%20and%20Enzymes">Sonic Hedgehog/Shh</a>*</td> <td><a href="/target/vegf?category=Proteins%20and%20Enzymes">VEGF</a>*</td> <td><a href="/target/wnt-3a?category=Proteins%20and%20Enzymes">Wnt-3a</a>*</td> </tr> </tbody> </table> </div> <p><i>*GMP-grade proteins are available for these molecules.</i></p> <div class="row"> <div class="container"> <div class="row"> <div class="padded_row"> </div> </div> </div> </div> <h4><a class="btn btn-primary" href="/search?keywords=cytokines%20and%20growth%20factors&category=Proteins%20and%20Enzymes">Browse Other Cytokines for Stem Cell Culture</a></h4> </div> </div> </div> <p> </p> <div class="row"> <div class="padded_row"> <div class="col-xs-12"> <p><a href="/services/protein-services"><img alt="Custom Protein Services Banner" src="//resources.rndsystems.com/images/design/stem-cell-landing-rnd_custom-protein-services.png" width="100%" /></a></p> </div> </div> </div> <p> </p> <div class="row"> <div class="padded_row"> <div class="col-xs-12" id="neural"> <h2 style="margin-top: 30px">Neural Stem Cells</h2> <p>Neural stem cells (NSCs) are multipotent stem cells of the nervous system that give rise to most, if not all the cells found in the central nervous system, including astrocytes, neurons, and oligodendrocytes. Transplantation of neural stem cells is of particular interest as a potential cellular therapy for neurodegenerative diseases.</p> <div class="ultrex_table_wrapper"> <table cellpadding="8" cellspacing="0" class="table table-bordered table-stripped" width="100%"> <tbody> <tr> <td class="info" colspan="6"><strong>Cytokines for Neural Stem Cells</strong></td> </tr> <tr> <td><a href="/target/bdnf?category=Proteins%20and%20Enzymes">BDNF</a>*</td> <td><a href="/target/bmp-2?category=Proteins%20and%20Enzymes">BMP-2</a>*</td> <td><a href="/target/bmp-4?category=Proteins%20and%20Enzymes">BMP-4</a>*</td> <td><a href="/target/cntf?category=Proteins%20and%20Enzymes">CNTF</a></td> <td><a href="/target/egf?category=Proteins%20and%20Enzymes">EGF</a>*</td> <td><a href="/target/fgf-basic-fgf2-bfgf?category=Proteins%20and%20Enzymes">FGF basic/FGF2</a>*</td> </tr> <tr> <td><a href="/target/fgf-4?category=Proteins%20and%20Enzymes">FGF-4</a></td> <td><a href="/target/fgf-8?category=Proteins%20and%20Enzymes">FGF-8</a></td> <td><a href="/target/fgf-10?category=Proteins%20and%20Enzymes">FGF-10</a></td> <td><a href="/target/gdnf?category=Proteins%20and%20Enzymes">GDNF</a>*</td> <td><a href="/target/igf-i-igf-1?category=Proteins%20and%20Enzymes">IGF-I/IGF-1</a>*</td> <td><a href="/target/beta-ngf?category=Proteins%20and%20Enzymes">beta-NGF</a></td> </tr> <tr> <td><a href="/target/noggin?category=Proteins%20and%20Enzymes">Noggin</a>*</td> <td><a href="/target/nt-4?category=Proteins%20and%20Enzymes">NT-4</a></td> <td><a href="/target/pdgf-bb?category=Proteins%20and%20Enzymes">PDGF-BB</a>*</td> <td><a href="/target/sonic-hedgehog-shh?category=Proteins%20and%20Enzymes">Sonic Hedgehog/Shh</a>*</td> <td><a href="/target/vegf?category=Proteins%20and%20Enzymes">VEGF</a>*</td> <td> </td> </tr> </tbody> </table> </div> <p><i>*GMP-grade proteins are available for these molecules.</i></p> <p> </p> <div class="row"> <div class="padded_row"> <div class="col-xs-4"><img alt="Data showing competitor comparison testing of R&D Systems Recombinant Human Noggin protein" src="//resources.rndsystems.com/images/design/stem-cell-landing-rnd_graph-noggin-pt1.png" style="margin: 10px 0px;" width="100%" /></div> <div class="col-xs-4"><img alt="ESCs differentiated with R&D Systems Noggin or Noggin from Competitor 2 immunostained for Otx2 and SOX1" src="//resources.rndsystems.com/images/design/stem-cell-landing-rnd_graph-noggin-pt2.png" style="margin: 10px 0px;" width="100%" /></div> <div class="col-xs-4"><img alt="Quantification of SOX1+ clusters in ESCs grown under the indicated culture conditions" src="//resources.rndsystems.com/images/design/stem-cell-landing-rnd_graph-noggin-pt3.png" style="margin: 10px 0px;" width="100%" /></div> </div> </div> <p> </p> <div class="row"> <div class="padded_row"> <div class="col-xs-12"> <p><strong>R&D Systems Recombinant Human Noggin is 30-fold More Active than Recombinant Human Noggin from a Leading Competitor and Displays Minimal Lot-to-Lot Variability. (A)</strong> The bioactivity of R&D Systems <a href="/products/recombinant-human-noggin-protein_6057-ng">Recombinant Human Noggin</a> (Catalog # 6057-NG; orange line) or recombinant human Noggin from a top competitor (green line) was determined by assessing the ability of the proteins to inhibit alkaline phosphatase production induced by 50 ng/mL <a href="/products/recombinant-human-bmp-4-protein_314-bp">Recombinant Human BMP-4</a> (R&D Systems, Catalog # 314-BP) in the ATDC5 mouse chondrogenic cell line. In the presence of 50 ng/mL Recombinant Human BMP-4, the ED<sub>50</sub> for this effect for R&D Systems Recombinant Human Noggin was approximately 30-fold greater than the top competitor’s Noggin protein. <strong>(B, C)</strong> BG01V human embryonic stem cells were cultured in Mouse Embryonic Fibroblast Conditioned Media supplemented with FGF basic (5 ng/mL). Stem cells were driven into early cells of the neuroectoderm using a 3-day incubation in 25 ug/mL of R&D Systems <a href="/products/recombinant-human-noggin-protein_6057-ng">Recombinant Human Noggin</a> (Lot 1, Lot 2; Catalog # 6057-NG) or recombinant human Noggin from two different competitors (Competitor 1, Competitor 2). Control cells were incubated in media without Noggin (No Noggin). The cells were stained for the early ectoderm marker, Otx2, and the neuroectoderm marker, SOX1. <strong>(B)</strong> Representative images of Otx2 (red), SOX1 (green), and DAPI (blue) staining in embryonic stem cells differentiated with Noggin from R&D Systems or Noggin from Competitor 2. <strong>(C)</strong> SOX1+ clusters were quantified under each of the indicated culture conditions. Cells treated with R&D Systems Recombinant Human Noggin showed an increase in SOX1+ cells compared to both the untreated and competitor-treated cells. R&D Systems Recombinant Human Noggin showed consistent differentiation across the lots tested. BG01V human embryonic stem cells were licensed from ViaCyte, Inc.</p> </div> </div> </div> </div> </div> </div> <p> </p> <div class="row"> <div class="padded_row"> <div class="col-xs-12" id="mesenchymal"> <h2 style="margin-top: 30px">Mesenchymal Stem Cells</h2> <p>Mesenchymal stem cells (MSCs) are multipotent stem cells that can differentiate to form adipocytes, cardiomyocytes, chondrocytes, and osteocytes. They are typically isolated from the bone marrow but MSCs can also be isolated from human umbilical cord blood, adipose, and synovium. Due to their multi-differentiation potential, mesenchymal stem cells have been widely investigated and applied in the area of regenerative medicine for their ability to regenerate musculoskeletal tissues, bone, cartilage, liver, nerve tissue, and skin. In addition, MSCs have been studied for their abilities to promote corneal and tracheal reconstruction, and myocardial damage repair.</p> <div class="ultrex_table_wrapper"> <table cellpadding="8" cellspacing="0" class="table table-bordered table-stripped" width="100%"> <tbody> <tr> <td class="info" colspan="6"><strong>Cytokines for Mesenchymal Stem Cells</strong></td> </tr> <tr> <td><a href="/target/bmp-2?category=Proteins%20and%20Enzymes">BMP-2</a>*</td> <td><a href="/target/bmp-4?category=Proteins%20and%20Enzymes">BMP-4</a>*</td> <td><a href="/target/bmp-6?category=Proteins%20and%20Enzymes">BMP-6</a></td> <td><a href="/target/egf?category=Proteins%20and%20Enzymes">EGF</a>*</td> <td><a href="/target/fgf-basic-fgf2-bfgf?category=Proteins%20and%20Enzymes">FGF basic/FGF2</a>*</td> <td><a href="/target/fgf-4?category=Proteins%20and%20Enzymes">FGF-4</a></td> </tr> <tr> <td><a href="/target/gdf-5-bmp-14?category=Proteins%20and%20Enzymes">GDF-5/BMP-14</a></td> <td><a href="/target/hb-egf?category=Proteins%20and%20Enzymes">HB-EGF</a></td> <td><a href="/target/igf-i-igf-1?category=Proteins%20and%20Enzymes">IGF-I/IGF-1</a>*</td> <td><a href="/target/il-6?category=Proteins%20and%20Enzymes">IL-6</a>*</td> <td><a href="/target/pdgf-bb?category=Proteins%20and%20Enzymes">PDGF-BB</a>*</td> <td><a href="/target/sonic-hedgehog-shh?category=Proteins%20and%20Enzymes">Sonic Hedgehog/Shh</a>*</td> </tr> <tr> <td><a href="/target/tgf-beta-1?category=Proteins%20and%20Enzymes">TGF-beta 1</a>*</td> <td><a href="/target/tgf-beta-2?category=Proteins%20and%20Enzymes">TGF-beta 2</a></td> <td><a href="/target/tgf-beta-3?category=Proteins%20and%20Enzymes">TGF-beta 3</a></td> <td><a href="/target/wnt-5b?category=Proteins%20and%20Enzymes">Wnt-5b</a></td> <td><a href="/target/wnt-10b?category=Proteins%20and%20Enzymes">Wnt-10b</a></td> <td> </td> </tr> </tbody> </table> </div> <p><i>*GMP-grade proteins are available for these molecules.</i></p> </div> </div> </div> <p> </p> <div class="row"> <div class="padded_row"> <div class="col-xs-12" id="hematopoietic"> <h2 style="margin-top: 30px">Hematopoietic Stem Cells</h2> <p>Hematopoietic stem cells (HSCs) are multipotent cells found in the adult bone marrow, peripheral blood, and umbilical cord blood. These cells can develop into all of the different cell types found in the blood, including B cells, dendritic cells, monocytes, natural killer cells, T cells, basophils, eosinophils, neutrophils, erythrocytes, and platelets. HSCs have been used to treat hematologic malignancies, blood disorders, liver disease, and to replace or repopulate patients’ hematopoietic systems.</p> <div class="ultrex_table_wrapper"> <table cellpadding="8" cellspacing="0" class="table table-bordered table-stripped" width="100%"> <tbody> <tr> <td class="info" colspan="5"><strong>Cytokines for Hematopoietic Stem Cells</strong></td> </tr> <tr> <td><a href="/target/bmp-4?category=Proteins%20and%20Enzymes">BMP-4</a>*</td> <td><a href="/target/erythropoietin-epo?category=Proteins%20and%20Enzymes">Erythropoietin/EPO</a></td> <td><a href="/target/flt-3-ligand-flt3l?category=Proteins%20and%20Enzymes">Flt-3 Ligand/FLT3L</a>*</td> <td><a href="/target/g-csf?category=Proteins%20and%20Enzymes">G-CSF</a></td> <td><a href="/target/gm-csf?category=Proteins%20and%20Enzymes">GM-CSF</a>*</td> </tr> <tr> <td><a href="/target/ifn-gamma?category=Proteins%20and%20Enzymes">IFN-gamma</a>*</td> <td><a href="/target/il-2?category=Proteins%20and%20Enzymes">IL-2</a>*</td> <td><a href="/target/il-3?category=Proteins%20and%20Enzymes">IL-3</a>*</td> <td><a href="/target/il-4?category=Proteins%20and%20Enzymes">IL-4</a>*</td> <td><a href="/target/il-6?category=Proteins%20and%20Enzymes">IL-6</a>*</td> </tr> <tr> <td><a href="/target/il-7?category=Proteins%20and%20Enzymes">IL-7</a>*</td> <td><a href="/target/il-10?category=Proteins%20and%20Enzymes">IL-10</a>*</td> <td><a href="/target/il-11?category=Proteins%20and%20Enzymes">IL-11</a></td> <td><a href="/target/il-15?category=Proteins%20and%20Enzymes">IL-15</a>*</td> <td><a href="/target/il-21?category=Proteins%20and%20Enzymes">IL-21</a>*</td> </tr> <tr> <td><a href="/target/m-csf?category=Proteins%20and%20Enzymes">M-CSF</a>*</td> <td><a href="/target/scf-c-kit-ligand?category=Proteins%20and%20Enzymes">SCF/c-kit Ligand</a>*</td> <td><a href="/target/thrombopoietin-tpo?category=Proteins%20and%20Enzymes">Thrombopoietin/TPO</a>*</td> <td><a href="/target/vegf?category=Proteins%20and%20Enzymes">VEGF</a>*</td> <td><a href="/target/wnt-3a?category=Proteins%20and%20Enzymes">Wnt-3a</a>*</td> </tr> </tbody> </table> </div> <p><i>*GMP-grade proteins are available for these molecules.</i></p> </div> </div> </div> <p> </p> <div class="row"> <div class="padded_row"> <div class="col-xs-12"> <p><a href="/services/bulk-quote-request "><img alt="Are You in Need of Large Quantities of a Particular Protein? Request a Bulk Protein Quote." src="//resources.rndsystems.com/images/design/stem-cell-landing-rnd_thin-banner-ad8.png" width="100%" /></a></p> </div> </div> </div> <p> </p> <div class="row"> <div class="padded_row"> <div class="col-xs-12"> <h2>Key Benefits of Using R&D Systems Proteins for Stem Cell Culture</h2> <ul> <li><strong>High Levels of Biological Activity:</strong> Utilizing over 900 different bioassays, the biological activity of every protein we offer is tested in an appropriate bioassay to confirm that it meets our strict QC activity parameters.</li> <li><strong>Lot-to-Lot Consistency:</strong> Minimal lot-to-lot variability is ensured by testing each new lot side-by-side with previous lots and with a master lot, so you don’t have to worry whether results will be reproducible over time.</li> <li><strong>High Purity and Low Endotoxin Levels:</strong> Our proteins are typically over 95% pure and have a guaranteed industry-leading endotoxin level of ≤0.1 EU/ug by the LAL method.</li> <li><strong>Seamless transition from preclinical research to clinical manufacturing:</strong> Our Animal-free RUO proteins originate from the same clone, sequence, and expression system as our Animal-free GMP-grade proteins, allowing for a seamless transition from preclinical research into clinical manufacturing.</li> <li><strong>Supply Chain Reliability:</strong> Our team has the experience and the capacity to ensure that we can provide you with a stable supply of the proteins you need for your research.</li> <li><strong>Bulk Proteins at Discounted Prices:</strong> We have the capacity and the expertise to scale up the production of any protein and we offer economical pricing on bulk orders.</li> <li><strong>Custom Protein Capabilities:</strong> For specialized protein requests, you can always contact our <a href="/services/protein-services">Custom Protein Services</a> team. We have the expertise and the systems necessary to develop the proteins required to advance your research.</li> <li><strong>Comprehensive Portfolio of Reagents for Your Entire Workflow:</strong> Along with our proteins, we also offer a wide range of other products for stem cell culture and characterization, including <a href="/products/cultrex-basement-membrane-extract-bme-and-extracellular-matrices-ecm">Cultrex™ Basement Membrane Extracts and Extracellular Matrices</a>, <a href="/search?keywords=stem+cell+media">media and media supplements</a>, <a href="https://www.tocris.com/cell-biology/stem-cells" target="_blank">Tocris™ small molecules</a>, <a href="/products/stem-cell-differentiation-kits-and-media-supplements">stem cell differentiation</a> and <a href="/search?keywords=identification+kit">functional identification kits</a>, <a href="/search?keywords=antibody%20panel&category=Stem%20Cell%20Products">antibody panels</a>, <a href="/products/elisas">immunoassays</a>, <a href="https://www.bio-techne.com/reagents/rnascope-ish-technology" target="_blank">RNAscope™ ISH assays</a>, and <a href="https://www.bio-techne.com/brands/proteinsimple" target="_blank">analytical instruments</a> to automate different steps of your workflow.</li> </ul> </div> </div> </div> <p> </p> <p><script> var btn = document.querySelector('button'); btn.addEventListener('click', function(){ var hint = document.getElementById('Cell'); if(hint.style.display == 'block'){ hint.style.display = 'none'; } else{ hint.style.display = 'block'; } }); function labnolIframe(div) { var iframe = document.createElement('iframe'); iframe.setAttribute( 'src', 'https://www.youtube.com/embed/' + div.dataset.id + '?autoplay=1&rel=0' ); iframe.setAttribute('frameborder', '0'); iframe.setAttribute('allowfullscreen', '1'); iframe.setAttribute( 'allow', 'accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture' ); div.parentNode.replaceChild(iframe, div); } document.addEventListener('DOMContentLoaded', initYouTubeVideos); </script></p> <div class="row"> <div class="padded_row"> <div class="col-xs-12"> <h2>R&D Systems Cytokines Are Frequently More Active than Leading Competitor’s Proteins</h2> </div> </div> </div> <div class="row"> <div class="padded_row"> <div class="col-xs-4"><img alt="Data showing competitor comparison testing of R&D Systems Recombinant Human Thrombopoietin protein" src="//resources.rndsystems.com/images/design/stem-cell-landing-rnd_graph-tpo.png" style="margin: 10px 0px;" width="100%" /> <p><strong>R&D Systems Recombinant Human Thrombopoietin/TPO Displays Higher Activity than Leading Competitors’ Thrombopoietin Proteins.</strong> The bioactivity of R&D Systems <a href="/products/recombinant-human-thrombopoietin-e-coli-expressed-cf_288-tpe">Recombinant Human Thrombopoietin</a> (Catalog # 288-TPE; orange line) or recombinant human Thrombopoietin/TPO from two different competitors (green and purple lines) was assessed by measuring the ability of the proteins to stimulate proliferation of the MO7e human megakaryocytic leukemic cell line. The ED<sub>50</sub> for this effect for R&D Systems Recombinant Human Thrombopoietin is 0.05-0.5 ng/mL, which is over 2-fold more active than the two competitors’ proteins.</p> </div> <div class="col-xs-4"><img alt="Data showing competitor comparison testing of R&D Systems Recombinant Human Wnt-3a protein" src="//resources.rndsystems.com/images/design/stem-cell-landing-rnd_graph-gdnf-13.png" style="margin: 10px 0px;" width="100%" /> <p><strong>R&D Systems Recombinant Human Wnt-3a Displays Higher Activity than a Leading Competitor’s Human Wnt-3a Protein.</strong> The bioactivity of R&D Systems <a href="/products/recombinant-human-wnt-3a-protein_5036-wn">Recombinant Human Wnt-3a</a> (Catalog # 5036-WN; orange line) or recombinant human Wnt-3a from another company (green line) was assessed by measuring the ability of the proteins to induce alkaline phosphatase production in the MC3T3-E1 mouse preosteoblast cell line. The ED<sub>50</sub> of R&D Systems Recombinant Human Wnt-3a was 1.7-fold better than the leading competitor’s Wnt-3a protein, with more than twice the maximum response.</p> </div> <div class="col-xs-4"><img alt="Data showing competitor comparison testing of R&D Systems Recombinant Human GDNF protein" src="//resources.rndsystems.com/images/design/stem-cell-landing-rnd_graph-gdnf-14.png" style="margin: 10px 0px;" width="100%" /> <p><strong>R&D Systems Recombinant Human GDNF Displays Higher Activity than a Leading Competitor’s Recombinant Human GDNF Protein.</strong> The bioactivity of R&D Systems <a href="/products/recombinant-human-gdnf-protein_212-gd">Recombinant Human GDNF</a> (Catalog # 212-GD; orange line) or recombinant human GDNF from another company (blue line) was assessed by measuring the ability of the proteins to stimulate the proliferation of SH-SY5Y human neuroblastoma cells, in the presence of <a href="/products/recombinant-human-gfr-alpha-1-fc-chimera-protein-cf_714-gr">Recombinant Human GFR alpha-1</a> (R&D Systems, Catalog # 714-GR). The activity of the R&D Systems GDNF protein was approximately 9-fold greater than the leading competitor’s GDNF protein.</p> </div> </div> </div> <div class="row"> <div class="padded_row"> <div class="col-xs-12"> <h2 style="line-height: normal;">R&D Systems Cytokines Are Rigorously Tested to Ensure High Lot-to-Lot Consistency</h2> </div> </div> </div> <div class="row"> <div class="padded_row"> <div class="col-xs-4"><img alt="Data showing lot-to-lot consistency testing of R&D Systems Recombinant Human Noggin protein" src="//resources.rndsystems.com/images/design/stem-cell-landing-rnd_graph-noggin2.png" style="margin: 10px 0px;" width="100%" /> <p><strong>Lot-to-Lot Consistency Testing of Recombinant Human Noggin.</strong> The lot-to-lot consistency of R&D Systems <a href="/products/recombinant-human-noggin-protein_6057-ng">Recombinant Human Noggin</a> (Catalog # 6057-NG; orange, green, purple lines) was assessed by testing the ability of three independent lots of the protein to inhibit BMP-4-induced alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. The ED<sub>50</sub> for this effect is 0.02-0.16 ug/mL, in the presence of 50 ng/mL Recombinant Human BMP-4. Each trace on the graph represents data obtained from Recombinant Human Noggin from a different manufacturing run. The dark blue line on the graph is showing the ability of <a href="/products/recombinant-human-bmp-4-protein_314-bp">Recombinant Human BMP-4</a> (R&D Systems, Catalog # 314-BP; 50 ng/mL) to induce alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line.</p> </div> <div class="col-xs-4"><img alt="Data showing lot-to-lot consistency testing of R&D Systems Recombinant Human Wnt-3a protein" src="//resources.rndsystems.com/images/design/stem-cell-landing-rnd_graph-wnt2-updated.png" style="margin: 10px 0px;" width="100%" /> <p><strong>Lot-to-Lot Consistency Testing of Recombinant Human Wnt-3a.</strong> The lot-to-lot consistency of R&D Systems <a href="/products/recombinant-human-wnt-3a-protein_5036-wn">Recombinant Human Wnt-3a</a> (Catalog # 5036-WN) was assessed by testing the ability of three independent lots of the protein to induce alkaline phosphatase production in the MC3T3-E1 mouse preosteoblast cell line. The ED<sub>50</sub> for this effect is <500 ng/mL. Each trace on the graph represents data obtained from Recombinant Human Wnt-3a from a different manufacturing run.</p> </div> <div class="col-xs-4"><img alt="Data showing lot-to-lot consistency testing of R&D Systems GMP-grade Recombinant Human VEGF165 protein" src="//resources.rndsystems.com/images/design/stem-cell-landing-rnd_graph-gmp.png" style="margin: 10px 0px;" width="100%" /> <p><strong>Lot-to-Lot Consistency Testing of Animal-free GMP-grade Recombinant Human VEGF<sub>165</sub>.</strong> The lot-to-lot consistency of R&D Systems GMP-grade <a href="/products/recombinant-human-vegf-165-gmp-protein-cf_bt-vegf-gmp">Recombinant Human VEGF<sub>165</sub></a> (Catalog # BT-VEGF-GMP) was assessed by testing the ability of three independent lots of the protein to stimulate proliferation of HUVEC human umbilical vein endothelial cells. The ED<sub>50</sub> for this effect is 1.5-12.0 ng/mL. Each trace on the graph represents data obtained from GMP-grade Recombinant Human VEGF<sub>165</sub> from a different manufacturing run.</p> </div> </div> </div> <p> </p> <p> </p> <div class="row"> <div class="padded_row"> <div class="col-xs-12"> <p><a href="/products/animal-free-recombinant-proteins"><img alt="Browse Animal-Free Proteins" src="//resources.rndsystems.com/images/design/stem-cell-landing-rnd_Animal-Free-banner-ad7.png" width="100%" /></a></p> </div> </div> </div> <p> </p> <div class="row"> <div class="padded_row"> <div class="col-xs-12"> <h2 id="resources">Stem Cell-Related Resources</h2> </div> <div class="col-xs-6"> <p><a href="/products/cultrex-basement-membrane-extract-bme-and-extracellular-matrices-ecm">Cultrex™ Basement Membrane Extracts and Extracellular Matrices for<br /> Stem Cell Culture</a></p> <p><a href="/products/stem-cell-products">Media and Supplements for Stem Cell Culture</a></p> <p><a href="https://www.tocris.com/cell-biology/stem-cells" target="_blank">Small Molecules for Stem Cell Research</a></p> <p><a href="/products/stem-cell-differentiation-kits-and-media-supplements">Stem Cell Differentiation Kits and Media Supplements</a></p> <p><a href="/search?keywords=identification+kit">Stem Cell Functional Identification Kits</a></p> <p><a href="/search?keywords=antibody%20panel&category=Stem%20Cell%20Products">Stem Cell Marker Antibody Panels</a></p> <p><a href="/products/organoid-and-3d-culture-reagents">Organoid and 3-D Cell Culture Products</a></p> </div> <div class="col-xs-6"> <p><a href="/resources/articles/optimizing-organoid-culture-conditions-importance-growth-factor-bioactivity-and-reagent-consistency">Optimizing Organoid Culture Conditions: The Importance of Growth Factor Bioactivity and Reagent Consistency Application Note</a></p> <p><a href="/resources/literature/organoid-culture-handbook">The Organoid Culture Handbook</a></p> <p><a 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