Ion channel families | IUPHAR/BPS Guide to PHARMACOLOGY

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list of <a href="IonChannelListForward?class=VGIC">voltage-gated ion channels</a>, <a href="IonChannelListForward?class=LGIC">ligand-gated ion channels</a> or <a href="IonChannelListForward?class=OTHERIC">other ion channels</a> </p> <div style="text-align:right;"> <button class="button_gtoimmupdb_off" onClick='window.location.href="http://www.guidetoimmunopharmacology.org/GRAC/ReceptorFamiliesForward?type=IC&CGTP=false"; return false;'>GtoImmuPdb View OFF</button> <button onClick="expandTree('family_tree');return false;">Expand all nodes</button> <button onClick="collapseTree('family_tree'); return false;">Collapse all nodes</button> </div> <table> <tr> <td width="400px"> <ul class="mktree" id ="family_tree"><li class="liOpen" ID="node689"><span class="tree_root_node">Ion channels</span><span class="cgtp"> C</span> <a href="FamilyDisplayForward?familyId=689&familyType=IC"><img style="vertical-align:top;" src="images/overview.png"/></a><ul style="margin-bottom:0px;"><li class="liOpen" ID="node697">Ligand-gated ion channels<span class="cgtp"> C</span> <a href="FamilyDisplayForward?familyId=697&familyType=IC"><img style="vertical-align:top;" src="images/overview.png"/></a><ul style="margin-bottom:0px;"><li ID="node68"><a id="link68" href="FamilyDisplayForward?familyId=68">5-HT<sub>3</sub> receptors</a><span class="cgtp"> C</span></li><li ID="node118"><a id="link118" href="FamilyDisplayForward?familyId=118">Acid-sensing (proton-gated) ion channels (ASICs)</a><span class="cgtp"> C</span></li><li ID="node122"><a id="link122" href="FamilyDisplayForward?familyId=122">Epithelial sodium channel (ENaC)</a><span class="cgtp"> C</span></li><li ID="node72"><a id="link72" href="FamilyDisplayForward?familyId=72">GABA<sub>A</sub> receptors</a><span class="cgtp"> C</span></li><li ID="node73"><a id="link73" href="FamilyDisplayForward?familyId=73">Glycine receptors</a><span class="cgtp"> C</span></li><li ID="node75"><a id="link75" href="FamilyDisplayForward?familyId=75">Ionotropic glutamate receptors</a><span class="cgtp"> C</span></li><li ID="node123"><a id="link123" href="FamilyDisplayForward?familyId=123">IP<sub>3</sub> receptors</a><span class="cgtp"> C</span></li><li ID="node76"><a id="link76" href="FamilyDisplayForward?familyId=76">Nicotinic acetylcholine receptors (nACh)</a><span class="cgtp"> C</span></li><li ID="node77"><a id="link77" href="FamilyDisplayForward?familyId=77">P2X receptors</a><span class="cgtp"> C</span></li><li ID="node83"><a id="link83" href="FamilyDisplayForward?familyId=83">ZAC</a><span class="cgtp"> C</span></li></ul></li><li class="liOpen" ID="node696">Voltage-gated ion channels<span class="cgtp"> C</span> <a href="FamilyDisplayForward?familyId=696&familyType=IC"><img style="vertical-align:top;" src="images/overview.png"/></a><ul style="margin-bottom:0px;"><li ID="node70"><a id="link70" href="FamilyDisplayForward?familyId=70">CatSper and Two-Pore channels (TPC)</a><span class="cgtp"> C</span></li><li ID="node71"><a id="link71" href="FamilyDisplayForward?familyId=71">Cyclic nucleotide-regulated channels (CNG)</a><span class="cgtp"> C</span></li><li ID="node133">Potassium channels<span class="cgtp"> C</span> <a href="FamilyDisplayForward?familyId=133&familyType=IC"><img style="vertical-align:top;" src="images/overview.png"/></a><ul style="margin-bottom:0px;"><li ID="node69"><a id="link69" href="FamilyDisplayForward?familyId=69">Calcium- and sodium-activated potassium channels (K<sub>Ca</sub>, K<sub>Na</sub>)</a><span class="cgtp"> C</span></li><li ID="node74"><a id="link74" href="FamilyDisplayForward?familyId=74">Inwardly rectifying potassium channels (K<sub>IR</sub>)</a><span class="cgtp"> C</span></li><li ID="node79"><a id="link79" href="FamilyDisplayForward?familyId=79">Two-pore domain potassium channels (K<sub>2P</sub>)</a><span class="cgtp"> C</span></li><li ID="node81"><a id="link81" href="FamilyDisplayForward?familyId=81">Voltage-gated potassium channels (K<sub>v</sub>)</a><span class="cgtp"> C</span></li></ul></li><li ID="node125"><a id="link125" href="FamilyDisplayForward?familyId=125">Ryanodine receptors (RyR)</a><span class="cgtp"> C</span></li><li ID="node78"><a id="link78" href="FamilyDisplayForward?familyId=78">Transient Receptor Potential channels (TRP)</a><span class="cgtp"> C</span></li><li ID="node80"><a id="link80" href="FamilyDisplayForward?familyId=80">Voltage-gated calcium channels (Ca<sub>V</sub>)</a><span class="cgtp"> C</span></li><li ID="node124"><a id="link124" href="FamilyDisplayForward?familyId=124">Voltage-gated proton channel (H<sub>v</sub>1)</a><span class="cgtp"> C</span></li><li ID="node82"><a id="link82" href="FamilyDisplayForward?familyId=82">Voltage-gated sodium channels (Na<sub>V</sub>)</a><span class="cgtp"> C</span></li></ul></li><li class="liOpen" ID="node861">Other ion channels<span class="cgtp"> C</span> <a href="FamilyDisplayForward?familyId=861&familyType=IC"><img style="vertical-align:top;" src="images/overview.png"/></a><ul style="margin-bottom:0px;"><li ID="node119"><a id="link119" href="FamilyDisplayForward?familyId=119">Aquaporins</a><span class="cgtp"> C</span></li><li ID="node120">Chloride channels<span class="cgtp"> C</span> <a href="FamilyDisplayForward?familyId=120&familyType=IC"><img style="vertical-align:top;" src="images/overview.png"/></a><ul style="margin-bottom:0px;"><li ID="node128"><a id="link128" href="FamilyDisplayForward?familyId=128">ClC family</a><span class="cgtp"> C</span></li><li ID="node129"><a id="link129" href="FamilyDisplayForward?familyId=129">CFTR</a><span class="cgtp"> C</span></li><li ID="node130"><a id="link130" href="FamilyDisplayForward?familyId=130">Calcium activated chloride channel (CaCC)</a><span class="cgtp"> C</span></li><li ID="node131"><a id="link131" href="FamilyDisplayForward?familyId=131">Maxi chloride channel</a><span class="cgtp"> C</span></li><li ID="node132"><a id="link132" href="FamilyDisplayForward?familyId=132">Volume regulated chloride channels (VRAC)</a><span class="cgtp"> C</span></li></ul></li><li ID="node121"><a id="link121" href="FamilyDisplayForward?familyId=121">Connexins and Pannexins</a><span class="cgtp"> C</span></li><li ID="node967"><a id="link967" href="FamilyDisplayForward?familyId=967">Piezo channels</a><span class="cgtp"> C</span></li><li ID="node126"><a id="link126" href="FamilyDisplayForward?familyId=126">Sodium leak channel, non-selective (Na<sub>Vi</sub>)</a><span class="cgtp"> C</span></li><li ID="node976">Store-operated ion channels<span class="cgtp"> C</span><ul style="margin-bottom:0px;"><li ID="node977"><a id="link977" href="FamilyDisplayForward?familyId=977">Orai channels</a><span class="cgtp"> C</span></li></ul></li></ul></li></ul></li> </td> <td width="400px" valign="top" text-align="right" style="padding:25px 0px 0px 25px"> <img id="myImg" src="images/VGIC_Dendrogram.jpg" alt="Representation of the amino acid sequence relations of the minimal pore regions of the voltage-gated ion channel superfamily. 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