CINXE.COM

<!DOCTYPE html> <html class="client-nojs vector-feature-language-in-header-enabled vector-feature-language-in-main-page-header-disabled vector-feature-sticky-header-disabled vector-feature-page-tools-pinned-disabled vector-feature-toc-pinned-clientpref-1 vector-feature-main-menu-pinned-disabled vector-feature-limited-width-clientpref-1 vector-feature-limited-width-content-enabled vector-feature-custom-font-size-clientpref-1 vector-feature-appearance-pinned-clientpref-1 vector-feature-night-mode-enabled skin-theme-clientpref-day vector-toc-available" lang="en" dir="ltr"> <head> <meta charset="UTF-8"> <title>Medial forebrain bundle - Wikipedia</title> <script>(function(){var className="client-js vector-feature-language-in-header-enabled vector-feature-language-in-main-page-header-disabled vector-feature-sticky-header-disabled vector-feature-page-tools-pinned-disabled vector-feature-toc-pinned-clientpref-1 vector-feature-main-menu-pinned-disabled vector-feature-limited-width-clientpref-1 vector-feature-limited-width-content-enabled vector-feature-custom-font-size-clientpref-1 vector-feature-appearance-pinned-clientpref-1 vector-feature-night-mode-enabled skin-theme-clientpref-day vector-toc-available";var cookie=document.cookie.match(/(?:^|; )enwikimwclientpreferences=([^;]+)/);if(cookie){cookie[1].split('%2C').forEach(function(pref){className=className.replace(new RegExp('(^| )'+pref.replace(/-clientpref-\w+$|[^\w-]+/g,'')+'-clientpref-\\w+( |$)'),'$1'+pref+'$2');});}document.documentElement.className=className;}());RLCONF={"wgBreakFrames":false,"wgSeparatorTransformTable":["",""],"wgDigitTransformTable":["",""],"wgDefaultDateFormat":"dmy", "wgMonthNames":["","January","February","March","April","May","June","July","August","September","October","November","December"],"wgRequestId":"7eac6ff7-ee21-4635-b7f9-0fe6234c35df","wgCanonicalNamespace":"","wgCanonicalSpecialPageName":false,"wgNamespaceNumber":0,"wgPageName":"Medial_forebrain_bundle","wgTitle":"Medial forebrain bundle","wgCurRevisionId":1257690665,"wgRevisionId":1257690665,"wgArticleId":5120098,"wgIsArticle":true,"wgIsRedirect":false,"wgAction":"view","wgUserName":null,"wgUserGroups":["*"],"wgCategories":["CS1: long volume value","Neuroanatomy","Olfactory system"],"wgPageViewLanguage":"en","wgPageContentLanguage":"en","wgPageContentModel":"wikitext","wgRelevantPageName":"Medial_forebrain_bundle","wgRelevantArticleId":5120098,"wgIsProbablyEditable":true,"wgRelevantPageIsProbablyEditable":true,"wgRestrictionEdit":[],"wgRestrictionMove":[],"wgNoticeProject":"wikipedia","wgCiteReferencePreviewsActive":false,"wgFlaggedRevsParams":{"tags":{"status":{"levels":1}}}, "wgMediaViewerOnClick":true,"wgMediaViewerEnabledByDefault":true,"wgPopupsFlags":0,"wgVisualEditor":{"pageLanguageCode":"en","pageLanguageDir":"ltr","pageVariantFallbacks":"en"},"wgMFDisplayWikibaseDescriptions":{"search":true,"watchlist":true,"tagline":false,"nearby":true},"wgWMESchemaEditAttemptStepOversample":false,"wgWMEPageLength":10000,"wgRelatedArticlesCompat":[],"wgEditSubmitButtonLabelPublish":true,"wgULSPosition":"interlanguage","wgULSisCompactLinksEnabled":false,"wgVector2022LanguageInHeader":true,"wgULSisLanguageSelectorEmpty":false,"wgWikibaseItemId":"Q4287680","wgCheckUserClientHintsHeadersJsApi":["brands","architecture","bitness","fullVersionList","mobile","model","platform","platformVersion"],"GEHomepageSuggestedEditsEnableTopics":true,"wgGETopicsMatchModeEnabled":false,"wgGEStructuredTaskRejectionReasonTextInputEnabled":false,"wgGELevelingUpEnabledForUser":false};RLSTATE={"ext.globalCssJs.user.styles":"ready","site.styles":"ready","user.styles":"ready", "ext.globalCssJs.user":"ready","user":"ready","user.options":"loading","ext.cite.styles":"ready","skins.vector.search.codex.styles":"ready","skins.vector.styles":"ready","skins.vector.icons":"ready","jquery.makeCollapsible.styles":"ready","ext.wikimediamessages.styles":"ready","ext.visualEditor.desktopArticleTarget.noscript":"ready","ext.uls.interlanguage":"ready","wikibase.client.init":"ready","ext.wikimediaBadges":"ready"};RLPAGEMODULES=["ext.cite.ux-enhancements","site","mediawiki.page.ready","jquery.makeCollapsible","mediawiki.toc","skins.vector.js","ext.centralNotice.geoIP","ext.centralNotice.startUp","ext.gadget.ReferenceTooltips","ext.gadget.switcher","ext.urlShortener.toolbar","ext.centralauth.centralautologin","mmv.bootstrap","ext.popups","ext.visualEditor.desktopArticleTarget.init","ext.visualEditor.targetLoader","ext.echo.centralauth","ext.eventLogging","ext.wikimediaEvents","ext.navigationTiming","ext.uls.interface","ext.cx.eventlogging.campaigns","ext.cx.uls.quick.actions" ,"wikibase.client.vector-2022","ext.checkUser.clientHints","ext.growthExperiments.SuggestedEditSession"];</script> <script>(RLQ=window.RLQ||[]).push(function(){mw.loader.impl(function(){return["user.options@12s5i",function($,jQuery,require,module){mw.user.tokens.set({"patrolToken":"+\\","watchToken":"+\\","csrfToken":"+\\"}); }];});});</script> <link rel="stylesheet" href="/w/load.php?lang=en&modules=ext.cite.styles%7Cext.uls.interlanguage%7Cext.visualEditor.desktopArticleTarget.noscript%7Cext.wikimediaBadges%7Cext.wikimediamessages.styles%7Cjquery.makeCollapsible.styles%7Cskins.vector.icons%2Cstyles%7Cskins.vector.search.codex.styles%7Cwikibase.client.init&only=styles&skin=vector-2022"> <script async="" src="/w/load.php?lang=en&modules=startup&only=scripts&raw=1&skin=vector-2022"></script> <meta name="ResourceLoaderDynamicStyles" content=""> <link rel="stylesheet" href="/w/load.php?lang=en&modules=site.styles&only=styles&skin=vector-2022"> <meta name="generator" content="MediaWiki 1.44.0-wmf.8"> <meta name="referrer" content="origin"> <meta name="referrer" content="origin-when-cross-origin"> <meta name="robots" content="max-image-preview:standard"> <meta name="format-detection" content="telephone=no"> <meta property="og:image" content="https://upload.wikimedia.org/wikipedia/commons/b/be/Medial_Forebrain_Bundle.jpg"> <meta property="og:image:width" content="1200"> <meta property="og:image:height" content="1046"> <meta property="og:image" content="https://upload.wikimedia.org/wikipedia/commons/thumb/b/be/Medial_Forebrain_Bundle.jpg/800px-Medial_Forebrain_Bundle.jpg"> <meta property="og:image:width" content="800"> <meta property="og:image:height" content="697"> <meta property="og:image" content="https://upload.wikimedia.org/wikipedia/commons/thumb/b/be/Medial_Forebrain_Bundle.jpg/640px-Medial_Forebrain_Bundle.jpg"> <meta property="og:image:width" content="640"> <meta property="og:image:height" content="558"> <meta name="viewport" content="width=1120"> <meta property="og:title" content="Medial forebrain bundle - Wikipedia"> <meta property="og:type" content="website"> <link rel="preconnect" href="//upload.wikimedia.org"> <link rel="alternate" media="only screen and (max-width: 640px)" href="//en.m.wikipedia.org/wiki/Medial_forebrain_bundle"> <link rel="alternate" type="application/x-wiki" title="Edit this page" href="/w/index.php?title=Medial_forebrain_bundle&action=edit"> <link rel="apple-touch-icon" href="/static/apple-touch/wikipedia.png"> <link rel="icon" href="/static/favicon/wikipedia.ico"> <link rel="search" type="application/opensearchdescription+xml" href="/w/rest.php/v1/search" title="Wikipedia (en)"> <link rel="EditURI" type="application/rsd+xml" href="//en.wikipedia.org/w/api.php?action=rsd"> <link rel="canonical" href="https://en.wikipedia.org/wiki/Medial_forebrain_bundle"> <link rel="license" href="https://creativecommons.org/licenses/by-sa/4.0/deed.en"> <link rel="alternate" type="application/atom+xml" title="Wikipedia Atom feed" href="/w/index.php?title=Special:RecentChanges&feed=atom"> <link rel="dns-prefetch" href="//meta.wikimedia.org" /> <link rel="dns-prefetch" href="login.wikimedia.org"> </head> <body class="skin--responsive skin-vector skin-vector-search-vue mediawiki ltr sitedir-ltr mw-hide-empty-elt ns-0 ns-subject mw-editable page-Medial_forebrain_bundle rootpage-Medial_forebrain_bundle skin-vector-2022 action-view"><a class="mw-jump-link" href="#bodyContent">Jump to content</a> <div class="vector-header-container"> <header class="vector-header mw-header"> <div class="vector-header-start"> <nav class="vector-main-menu-landmark" aria-label="Site"> <div id="vector-main-menu-dropdown" class="vector-dropdown vector-main-menu-dropdown vector-button-flush-left vector-button-flush-right" > <input type="checkbox" id="vector-main-menu-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-main-menu-dropdown" class="vector-dropdown-checkbox " aria-label="Main menu" > <label id="vector-main-menu-dropdown-label" for="vector-main-menu-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-menu mw-ui-icon-wikimedia-menu"></span> <span class="vector-dropdown-label-text">Main menu</span> </label> <div class="vector-dropdown-content"> <div id="vector-main-menu-unpinned-container" class="vector-unpinned-container"> <div id="vector-main-menu" class="vector-main-menu vector-pinnable-element"> <div class="vector-pinnable-header vector-main-menu-pinnable-header vector-pinnable-header-unpinned" data-feature-name="main-menu-pinned" data-pinnable-element-id="vector-main-menu" data-pinned-container-id="vector-main-menu-pinned-container" data-unpinned-container-id="vector-main-menu-unpinned-container" > <div class="vector-pinnable-header-label">Main menu</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-main-menu.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-main-menu.unpin">hide</button> </div> <div id="p-navigation" class="vector-menu mw-portlet mw-portlet-navigation" > <div class="vector-menu-heading"> Navigation </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="n-mainpage-description" class="mw-list-item"><a href="/wiki/Main_Page" title="Visit the main page [z]" accesskey="z"><span>Main page</span></a></li><li id="n-contents" class="mw-list-item"><a href="/wiki/Wikipedia:Contents" title="Guides to browsing Wikipedia"><span>Contents</span></a></li><li id="n-currentevents" class="mw-list-item"><a href="/wiki/Portal:Current_events" title="Articles related to current events"><span>Current events</span></a></li><li id="n-randompage" class="mw-list-item"><a href="/wiki/Special:Random" title="Visit a randomly selected article [x]" accesskey="x"><span>Random article</span></a></li><li id="n-aboutsite" class="mw-list-item"><a href="/wiki/Wikipedia:About" title="Learn about Wikipedia and how it works"><span>About Wikipedia</span></a></li><li id="n-contactpage" class="mw-list-item"><a href="//en.wikipedia.org/wiki/Wikipedia:Contact_us" title="How to contact Wikipedia"><span>Contact us</span></a></li> </ul> </div> </div> <div id="p-interaction" class="vector-menu mw-portlet mw-portlet-interaction" > <div class="vector-menu-heading"> Contribute </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="n-help" class="mw-list-item"><a href="/wiki/Help:Contents" title="Guidance on how to use and edit Wikipedia"><span>Help</span></a></li><li id="n-introduction" class="mw-list-item"><a href="/wiki/Help:Introduction" title="Learn how to edit Wikipedia"><span>Learn to edit</span></a></li><li id="n-portal" class="mw-list-item"><a href="/wiki/Wikipedia:Community_portal" title="The hub for editors"><span>Community portal</span></a></li><li id="n-recentchanges" class="mw-list-item"><a href="/wiki/Special:RecentChanges" title="A list of recent changes to Wikipedia [r]" accesskey="r"><span>Recent changes</span></a></li><li id="n-upload" class="mw-list-item"><a href="/wiki/Wikipedia:File_upload_wizard" title="Add images or other media for use on Wikipedia"><span>Upload file</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> <a href="/wiki/Main_Page" class="mw-logo"> <img class="mw-logo-icon" src="/static/images/icons/wikipedia.png" alt="" aria-hidden="true" height="50" width="50"> <span class="mw-logo-container skin-invert"> <img class="mw-logo-wordmark" alt="Wikipedia" src="/static/images/mobile/copyright/wikipedia-wordmark-en.svg" style="width: 7.5em; height: 1.125em;"> <img class="mw-logo-tagline" alt="The Free Encyclopedia" src="/static/images/mobile/copyright/wikipedia-tagline-en.svg" width="117" height="13" style="width: 7.3125em; height: 0.8125em;"> </span> </a> </div> <div class="vector-header-end"> <div id="p-search" role="search" class="vector-search-box-vue vector-search-box-collapses vector-search-box-show-thumbnail vector-search-box-auto-expand-width vector-search-box"> <a href="/wiki/Special:Search" class="cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only search-toggle" title="Search Wikipedia [f]" accesskey="f"><span class="vector-icon mw-ui-icon-search mw-ui-icon-wikimedia-search"></span> <span>Search</span> </a> <div class="vector-typeahead-search-container"> <div class="cdx-typeahead-search cdx-typeahead-search--show-thumbnail cdx-typeahead-search--auto-expand-width"> <form action="/w/index.php" id="searchform" class="cdx-search-input cdx-search-input--has-end-button"> <div id="simpleSearch" class="cdx-search-input__input-wrapper" data-search-loc="header-moved"> <div class="cdx-text-input cdx-text-input--has-start-icon"> <input class="cdx-text-input__input" type="search" name="search" placeholder="Search Wikipedia" aria-label="Search Wikipedia" autocapitalize="sentences" title="Search Wikipedia [f]" accesskey="f" id="searchInput" > <span class="cdx-text-input__icon cdx-text-input__start-icon"></span> </div> <input type="hidden" name="title" value="Special:Search"> </div> <button class="cdx-button cdx-search-input__end-button">Search</button> </form> </div> </div> </div> <nav class="vector-user-links vector-user-links-wide" aria-label="Personal tools"> <div class="vector-user-links-main"> <div id="p-vector-user-menu-preferences" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-userpage" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <nav class="vector-appearance-landmark" aria-label="Appearance"> <div id="vector-appearance-dropdown" class="vector-dropdown " title="Change the appearance of the page's font size, width, and color" > <input type="checkbox" id="vector-appearance-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-appearance-dropdown" class="vector-dropdown-checkbox " aria-label="Appearance" > <label id="vector-appearance-dropdown-label" for="vector-appearance-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-appearance mw-ui-icon-wikimedia-appearance"></span> <span class="vector-dropdown-label-text">Appearance</span> </label> <div class="vector-dropdown-content"> <div id="vector-appearance-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <div id="p-vector-user-menu-notifications" class="vector-menu mw-portlet emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> <div id="p-vector-user-menu-overflow" class="vector-menu mw-portlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="https://donate.wikimedia.org/?wmf_source=donate&wmf_medium=sidebar&wmf_campaign=en.wikipedia.org&uselang=en" class=""><span>Donate</span></a> </li> <li id="pt-createaccount-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Special:CreateAccount&returnto=Medial+forebrain+bundle" title="You are encouraged to create an account and log in; however, it is not mandatory" class=""><span>Create account</span></a> </li> <li id="pt-login-2" class="user-links-collapsible-item mw-list-item user-links-collapsible-item"><a data-mw="interface" href="/w/index.php?title=Special:UserLogin&returnto=Medial+forebrain+bundle" title="You're encouraged to log in; however, it's not mandatory. [o]" accesskey="o" class=""><span>Log in</span></a> </li> </ul> </div> </div> </div> <div id="vector-user-links-dropdown" class="vector-dropdown vector-user-menu vector-button-flush-right vector-user-menu-logged-out" title="Log in and more options" > <input type="checkbox" id="vector-user-links-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-user-links-dropdown" class="vector-dropdown-checkbox " aria-label="Personal tools" > <label id="vector-user-links-dropdown-label" for="vector-user-links-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-ellipsis mw-ui-icon-wikimedia-ellipsis"></span> <span class="vector-dropdown-label-text">Personal tools</span> </label> <div class="vector-dropdown-content"> <div id="p-personal" class="vector-menu mw-portlet mw-portlet-personal user-links-collapsible-item" title="User menu" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-sitesupport" class="user-links-collapsible-item mw-list-item"><a href="https://donate.wikimedia.org/?wmf_source=donate&wmf_medium=sidebar&wmf_campaign=en.wikipedia.org&uselang=en"><span>Donate</span></a></li><li id="pt-createaccount" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Special:CreateAccount&returnto=Medial+forebrain+bundle" title="You are encouraged to create an account and log in; however, it is not mandatory"><span class="vector-icon mw-ui-icon-userAdd mw-ui-icon-wikimedia-userAdd"></span> <span>Create account</span></a></li><li id="pt-login" class="user-links-collapsible-item mw-list-item"><a href="/w/index.php?title=Special:UserLogin&returnto=Medial+forebrain+bundle" title="You're encouraged to log in; however, it's not mandatory. [o]" accesskey="o"><span class="vector-icon mw-ui-icon-logIn mw-ui-icon-wikimedia-logIn"></span> <span>Log in</span></a></li> </ul> </div> </div> <div id="p-user-menu-anon-editor" class="vector-menu mw-portlet mw-portlet-user-menu-anon-editor" > <div class="vector-menu-heading"> Pages for logged out editors <a href="/wiki/Help:Introduction" aria-label="Learn more about editing"><span>learn more</span></a> </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="pt-anoncontribs" class="mw-list-item"><a href="/wiki/Special:MyContributions" title="A list of edits made from this IP address [y]" accesskey="y"><span>Contributions</span></a></li><li id="pt-anontalk" class="mw-list-item"><a href="/wiki/Special:MyTalk" title="Discussion about edits from this IP address [n]" accesskey="n"><span>Talk</span></a></li> </ul> </div> </div> </div> </div> </nav> </div> </header> </div> <div class="mw-page-container"> <div class="mw-page-container-inner"> <div class="vector-sitenotice-container"> <div id="siteNotice"></div> </div> <div class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="Site"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> <div class="vector-sticky-pinned-container"> <nav id="mw-panel-toc" aria-label="Contents" data-event-name="ui.sidebar-toc" class="mw-table-of-contents-container vector-toc-landmark"> <div id="vector-toc-pinned-container" class="vector-pinned-container"> <div id="vector-toc" class="vector-toc vector-pinnable-element"> <div class="vector-pinnable-header vector-toc-pinnable-header vector-pinnable-header-pinned" data-feature-name="toc-pinned" data-pinnable-element-id="vector-toc" > <h2 class="vector-pinnable-header-label">Contents</h2> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-toc.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">hide</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">(Top)</div> </a> </li> <li id="toc-Anatomy" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Anatomy"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Anatomy</span> </div> </a> <ul id="toc-Anatomy-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Function" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Function"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Function</span> </div> </a> <ul id="toc-Function-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Potential_role_in_diagnosis/treatment" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Potential_role_in_diagnosis/treatment"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Potential role in diagnosis/treatment</span> </div> </a> <ul id="toc-Potential_role_in_diagnosis/treatment-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Animal_research" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Animal_research"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Animal research</span> </div> </a> <ul id="toc-Animal_research-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>External links</span> </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Toggle the table of contents</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Medial forebrain bundle</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. Available in 5 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-5" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">5 languages</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%AD%D8%B2%D9%85%D8%A9_%D8%A7%D9%84%D8%AF%D9%85%D8%A7%D8%BA_%D8%A7%D9%84%D8%A3%D9%85%D8%A7%D9%85%D9%8A_%D8%A7%D9%84%D8%A5%D9%86%D8%B3%D9%8A%D8%A9" title="حزمة الدماغ الأمامي الإنسية – Arabic" lang="ar" hreflang="ar" data-title="حزمة الدماغ الأمامي الإنسية" data-language-autonym="العربية" data-language-local-name="Arabic" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Fasc%C3%ADculo_prosencef%C3%A1lico_medial" title="Fascículo prosencefálico medial – Spanish" lang="es" hreflang="es" data-title="Fascículo prosencefálico medial" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E5%86%85%E5%81%B4%E5%89%8D%E8%84%B3%E6%9D%9F" title="内側前脳束 – Japanese" lang="ja" hreflang="ja" data-title="内側前脳束" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%9C%D0%B5%D0%B4%D0%B8%D0%B0%D0%BB%D1%8C%D0%BD%D1%8B%D0%B9_%D0%BF%D1%83%D1%87%D0%BE%D0%BA_%D0%BF%D0%B5%D1%80%D0%B5%D0%B4%D0%BD%D0%B5%D0%B3%D0%BE_%D0%BC%D0%BE%D0%B7%D0%B3%D0%B0" title="Медиальный пучок переднего мозга – Russian" lang="ru" hreflang="ru" data-title="Медиальный пучок переднего мозга" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%9C%D0%B5%D0%B4%D1%96%D0%B0%D0%BB%D1%8C%D0%BD%D0%B8%D0%B9_%D0%BF%D0%B5%D1%80%D0%B5%D0%B4%D0%BD%D1%8C%D0%BE%D0%BC%D0%BE%D0%B7%D0%BA%D0%BE%D0%B2%D0%B8%D0%B9_%D0%BF%D1%83%D1%87%D0%BE%D0%BA" title="Медіальний передньомозковий пучок – Ukrainian" lang="uk" hreflang="uk" data-title="Медіальний передньомозковий пучок" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q4287680#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespaces"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Medial_forebrain_bundle" title="View the content page [c]" accesskey="c"><span>Article</span></a></li><li id="ca-talk" class="vector-tab-noicon mw-list-item"><a href="/wiki/Talk:Medial_forebrain_bundle" rel="discussion" title="Discuss improvements to the content page [t]" accesskey="t"><span>Talk</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown emptyPortlet" > <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-variants-dropdown" class="vector-dropdown-checkbox " aria-label="Change language variant" > <label id="vector-variants-dropdown-label" for="vector-variants-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">English</span> </label> <div class="vector-dropdown-content"> <div id="p-variants" class="vector-menu mw-portlet mw-portlet-variants emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> </div> </div> </nav> </div> <div id="right-navigation" class="vector-collapsible"> <nav aria-label="Views"> <div id="p-views" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-views" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-view" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Medial_forebrain_bundle"><span>Read</span></a></li><li id="ca-edit" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Medial_forebrain_bundle&action=edit" title="Edit this page [e]" accesskey="e"><span>Edit</span></a></li><li id="ca-history" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Medial_forebrain_bundle&action=history" title="Past revisions of this page [h]" accesskey="h"><span>View history</span></a></li> </ul> </div> </div> </nav> <nav class="vector-page-tools-landmark" aria-label="Page tools"> <div id="vector-page-tools-dropdown" class="vector-dropdown vector-page-tools-dropdown" > <input type="checkbox" id="vector-page-tools-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-tools-dropdown" class="vector-dropdown-checkbox " aria-label="Tools" > <label id="vector-page-tools-dropdown-label" for="vector-page-tools-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">Tools</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-tools-unpinned-container" class="vector-unpinned-container"> <div id="vector-page-tools" class="vector-page-tools vector-pinnable-element"> <div class="vector-pinnable-header vector-page-tools-pinnable-header vector-pinnable-header-unpinned" data-feature-name="page-tools-pinned" data-pinnable-element-id="vector-page-tools" data-pinned-container-id="vector-page-tools-pinned-container" data-unpinned-container-id="vector-page-tools-unpinned-container" > <div class="vector-pinnable-header-label">Tools</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-page-tools.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-page-tools.unpin">hide</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="More options" > <div class="vector-menu-heading"> Actions </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected vector-more-collapsible-item mw-list-item"><a href="/wiki/Medial_forebrain_bundle"><span>Read</span></a></li><li id="ca-more-edit" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Medial_forebrain_bundle&action=edit" title="Edit this page [e]" accesskey="e"><span>Edit</span></a></li><li id="ca-more-history" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Medial_forebrain_bundle&action=history"><span>View history</span></a></li> </ul> </div> </div> <div id="p-tb" class="vector-menu mw-portlet mw-portlet-tb" > <div class="vector-menu-heading"> General </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-whatlinkshere" class="mw-list-item"><a href="/wiki/Special:WhatLinksHere/Medial_forebrain_bundle" title="List of all English Wikipedia pages containing links to this page [j]" accesskey="j"><span>What links here</span></a></li><li id="t-recentchangeslinked" class="mw-list-item"><a href="/wiki/Special:RecentChangesLinked/Medial_forebrain_bundle" rel="nofollow" title="Recent changes in pages linked from this page [k]" accesskey="k"><span>Related changes</span></a></li><li id="t-upload" class="mw-list-item"><a href="/wiki/Wikipedia:File_Upload_Wizard" title="Upload files [u]" accesskey="u"><span>Upload file</span></a></li><li id="t-specialpages" class="mw-list-item"><a href="/wiki/Special:SpecialPages" title="A list of all special pages [q]" accesskey="q"><span>Special pages</span></a></li><li id="t-permalink" class="mw-list-item"><a href="/w/index.php?title=Medial_forebrain_bundle&oldid=1257690665" title="Permanent link to this revision of this page"><span>Permanent link</span></a></li><li id="t-info" class="mw-list-item"><a href="/w/index.php?title=Medial_forebrain_bundle&action=info" title="More information about this page"><span>Page information</span></a></li><li id="t-cite" class="mw-list-item"><a href="/w/index.php?title=Special:CiteThisPage&page=Medial_forebrain_bundle&id=1257690665&wpFormIdentifier=titleform" title="Information on how to cite this page"><span>Cite this page</span></a></li><li id="t-urlshortener" class="mw-list-item"><a href="/w/index.php?title=Special:UrlQ%C4%B1sald%C4%B1c%C4%B1s%C4%B1&url=https%3A%2F%2Fen.wikipedia.org%2Fwiki%2FMedial_forebrain_bundle"><span>Get shortened URL</span></a></li><li id="t-urlshortener-qrcode" class="mw-list-item"><a href="/w/index.php?title=Special:QrKodu&url=https%3A%2F%2Fen.wikipedia.org%2Fwiki%2FMedial_forebrain_bundle"><span>Download QR code</span></a></li> </ul> </div> </div> <div id="p-coll-print_export" class="vector-menu mw-portlet mw-portlet-coll-print_export" > <div class="vector-menu-heading"> Print/export </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="coll-download-as-rl" class="mw-list-item"><a href="/w/index.php?title=Special:DownloadAsPdf&page=Medial_forebrain_bundle&action=show-download-screen" title="Download this page as a PDF file"><span>Download as PDF</span></a></li><li id="t-print" class="mw-list-item"><a href="/w/index.php?title=Medial_forebrain_bundle&printable=yes" title="Printable version of this page [p]" accesskey="p"><span>Printable version</span></a></li> </ul> </div> </div> <div id="p-wikibase-otherprojects" class="vector-menu mw-portlet mw-portlet-wikibase-otherprojects" > <div class="vector-menu-heading"> In other projects </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-wikibase" class="wb-otherproject-link wb-otherproject-wikibase-dataitem mw-list-item"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q4287680" title="Structured data on this page hosted by Wikidata [g]" accesskey="g"><span>Wikidata item</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Page tools"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Appearance"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Appearance</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">move to sidebar</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">hide</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox"><tbody><tr><th colspan="2" class="infobox-above" style="background-color:lemonchiffon">Medial forebrain bundle</th></tr><tr><td colspan="2" class="infobox-image"><span class="mw-default-size" typeof="mw:File/Frameless"><a href="/wiki/File:Medial_Forebrain_Bundle.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/b/be/Medial_Forebrain_Bundle.jpg/250px-Medial_Forebrain_Bundle.jpg" decoding="async" width="250" height="218" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/be/Medial_Forebrain_Bundle.jpg/375px-Medial_Forebrain_Bundle.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/be/Medial_Forebrain_Bundle.jpg/500px-Medial_Forebrain_Bundle.jpg 2x" data-file-width="1022" data-file-height="891" /></a></span><div class="infobox-caption">Anatomical diagram of medial forebrain bundle. These neural fibres connect the septal area in <a href="/wiki/Forebrain" title="Forebrain">forebrain</a> with medial hypothalamus.</div></td></tr><tr><th colspan="2" class="infobox-header" style="background-color: #efefef">Details</th></tr><tr><th colspan="2" class="infobox-header" style="background-color: #efefef">Identifiers</th></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.25em"><a href="/wiki/Latin" title="Latin">Latin</a></th><td class="infobox-data"><i>fasciculus medialis telencephali</i></td></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.25em"><a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">MeSH</a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?ui=D008474">D008474</a></td></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.25em"><a href="/wiki/NeuroNames" title="NeuroNames">NeuroNames</a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="http://braininfo.rprc.washington.edu/centraldirectory.aspx?ID=433">433</a></td></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.25em"><a href="/wiki/NeuroLex" title="NeuroLex">NeuroLex</a> ID</th><td class="infobox-data"><a rel="nofollow" class="external text" href="http://uri.neuinfo.org/nif/nifstd/birnlex_908">birnlex_908</a></td></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.25em"><a href="/wiki/Terminologia_Anatomica" title="Terminologia Anatomica">TA98</a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="https://ifaa.unifr.ch/Public/EntryPage/TA98%20Tree/Entity%20TA98%20EN/14.1.08.955%20Entity%20TA98%20EN.htm">A14.1.08.955</a></td></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.25em"><a href="/wiki/Terminologia_Anatomica" title="Terminologia Anatomica">TA2</a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="https://ta2viewer.openanatomy.org/?id=5764">5764</a></td></tr><tr><th scope="row" class="infobox-label" style="padding-right:0.25em"><a href="/wiki/Foundational_Model_of_Anatomy" title="Foundational Model of Anatomy">FMA</a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="https://bioportal.bioontology.org/ontologies/FMA/?p=classes&conceptid=http%3A%2F%2Fpurl.org%2Fsig%2Font%2Ffma%2Ffma62064">62064</a></td></tr><tr><td colspan="2" class="infobox-below"><a href="/wiki/Anatomical_terms_of_neuroanatomy" title="Anatomical terms of neuroanatomy">Anatomical terms of neuroanatomy</a><div style="text-align: right;"><small class="noprint">[<a href="https://www.wikidata.org/wiki/Q4287680" class="extiw" title="d:Q4287680">edit on Wikidata</a>]</small></div></td></tr></tbody></table> <p>The <b>medial forebrain bundle</b> (<b>MFB</b>) is a <a href="/wiki/Neural_pathway" title="Neural pathway">neural pathway</a> containing <a href="/wiki/Axon" title="Axon">fibers</a> from the basal <a href="/wiki/Olfactory" class="mw-redirect" title="Olfactory">olfactory</a> regions, the <a href="/wiki/Periamygdaloid" class="mw-redirect" title="Periamygdaloid">periamygdaloid</a> region and the <a href="/wiki/Septal_nuclei" class="mw-redirect" title="Septal nuclei">septal nuclei</a>, as well as fibers from <a href="/wiki/Brainstem" title="Brainstem">brainstem</a> regions, including the <a href="/wiki/Ventral_tegmental_area" title="Ventral tegmental area">ventral tegmental area</a> and <a href="/wiki/Nigrostriatal_pathway" title="Nigrostriatal pathway">nigrostriatal pathway</a>. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Anatomy">Anatomy</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Medial_forebrain_bundle&action=edit&section=1" title="Edit section: Anatomy"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The MFB passes through the lateral <a href="/wiki/Hypothalamus" title="Hypothalamus">hypothalamus</a> and the <a href="/wiki/Basal_forebrain" title="Basal forebrain">basal forebrain</a> in a rostral-caudal direction. The MFB has its main projections to these regions of Brodmann areas (BA) 8, 9, 10, 11, 11m. The superior frontal region of MFB projects to BA 8, 9, 10; the rostral middle frontal projects to dorsolateral prefrontal cortex (BA 9, 10); lateral orbitofrontal of MFB shows its projections to nucleus accumbens septi (NAC) and ventral striatum as subcortical reward associated structures.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </p><p>It contains both ascending and descending fibers. The <a href="/wiki/Mesolimbic_pathway" title="Mesolimbic pathway">mesolimbic pathway</a>, which is a collection of dopaminergic neurons that projects from the <a href="/wiki/Ventral_tegmental_area" title="Ventral tegmental area">ventral tegmental area</a> to the <a href="/wiki/Nucleus_accumbens" title="Nucleus accumbens">nucleus accumbens</a>, is a component pathway of the MFB.<sup id="cite_ref-pmid11720786_2-0" class="reference"><a href="#cite_note-pmid11720786-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> </p><p>The MFB is one of the two major pathways connecting the limbic forebrain, midbrain, and hindbrain. The other one is the <a href="/w/index.php?title=Dorsal_diencephalic_conduction&action=edit&redlink=1" class="new" title="Dorsal diencephalic conduction (page does not exist)">dorsal diencephalic conduction</a> (DDC) system. The two pathways seem to have parallel <a href="/wiki/Neural_circuit" title="Neural circuit">neural circuits</a>, and share similar physiology and function.<sup id="cite_ref-Bianco_3-0" class="reference"><a href="#cite_note-Bianco-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Medial_forebrain_bundle&action=edit&section=2" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>It is commonly accepted that the MFB is a part of the <a href="/wiki/Reward_system" title="Reward system">reward system</a>, involved in the integration of reward and pleasure.<sup id="cite_ref-pmid16893295_4-0" class="reference"><a href="#cite_note-pmid16893295-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> Electrical stimulation of the medial forebrain bundle is believed to cause <a href="/wiki/Pleasure_center" class="mw-redirect" title="Pleasure center">sensations of pleasure</a>. This hypothesis is based upon <a href="/wiki/Intracranial_self-stimulation" class="mw-redirect" title="Intracranial self-stimulation">intracranial self-stimulation</a> (ICSS) studies. Animals will work for MFB ICSS, and humans report that MFB ICSS is intensely pleasurable.<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p><p>Another research technique that was used in determining the function of the MFB was <a href="/wiki/Microdialysis" title="Microdialysis">microdialysis</a>.<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Reinforcing electrical stimulation of the MFB using this method has shown to cause a release in <a href="/wiki/Dopamine" title="Dopamine">dopamine</a> in the <a href="/wiki/Nucleus_accumbens" title="Nucleus accumbens">nucleus accumbens</a>. Other microdialysis studies have shown that the presence of natural reinforcers such as food, water, and a sex partner cause a release in dopamine in the nucleus accumbens. This shows that the electrical stimulation of the MFB causes a similar effect compared to natural reinforcers. </p><p>The medial forebrain bundle has been shown to be linked to an individual's grief/sadness system through regulation of the individual's seeking/pleasure system.<sup id="cite_ref-pmid21184778_7-0" class="reference"><a href="#cite_note-pmid21184778-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Potential_role_in_diagnosis/treatment"><span id="Potential_role_in_diagnosis.2Ftreatment"></span>Potential role in diagnosis/treatment</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Medial_forebrain_bundle&action=edit&section=3" title="Edit section: Potential role in diagnosis/treatment"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The medial forebrain bundle may serve as a target in treating <a href="/wiki/Treatment-resistant_depression" title="Treatment-resistant depression">treatment-resistant depression</a>.<sup id="cite_ref-pmid25530019_8-0" class="reference"><a href="#cite_note-pmid25530019-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> Since the MFB connects areas of the brain which are involved with motivated behavior, mood regulation, and antidepressant response the stimulation of the MFB through <a href="/wiki/Deep_brain_stimulation" title="Deep brain stimulation">deep brain stimulation</a> could be an effective form of treatment. However, the anatomical definition of the tract system targeted by deep brain stimulation in humans has been intensively discussed and may indeed form the anterior limb of the internal capsule (and not the medial forebrain bundle proper, as defined in rodents). This topic has been worked up by <a href="/wiki/Suzanne_Haber" title="Suzanne Haber">Suzanne Haber</a> and other anatomists in detailed review articles.<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> Subjects that receive the deep brain stimulation treatment in the medial forebrain bundle have been reported to have high remission rates with normative functioning and no adverse side effects. </p><p>The medial forebrain bundle may also serve to study abuse-related drug effects through <a href="/wiki/Brain_stimulation_reward" title="Brain stimulation reward">intracranial self-stimulation</a>.<sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> ICSS targets the MFB at the level of the <a href="/wiki/Lateral_hypothalamus" title="Lateral hypothalamus">lateral hypothalamus</a> and elicits a range of responses from the subject through stimulation to acquire a baseline of responses. From this baseline the subject is then exposed to varying levels of stimuli in that are high/low in amplitude and frequency. These responses are then compared to the baseline of the subject to detect for sensitivity to the stimuli. Based on the sensitivity of the response from the subject, a level of inference on the drug abuse potential can be made. </p> <div class="mw-heading mw-heading2"><h2 id="Animal_research">Animal research</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Medial_forebrain_bundle&action=edit&section=4" title="Edit section: Animal research"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In animal studies studying the effects of <a href="/wiki/Levodopa-induced_dyskinesia" title="Levodopa-induced dyskinesia">Levodopa-induced dyskinesia</a>, a major complication in the treatment of <a href="/wiki/Parkinson%27s_disease" title="Parkinson's disease">Parkinson's disease</a>, lesions in the medial forebrain bundle show a maximum level of severity and sensitivity to <a href="/wiki/Levodopa" title="Levodopa">levodopa</a> and provide insight into the mechanisms of Levodopa-induced dyskinesia.<sup id="cite_ref-pmid24262181_11-0" class="reference"><a href="#cite_note-pmid24262181-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> Other lesions in the mouse, particularly in the <a href="/wiki/Striatum" title="Striatum">striatum 6-OHDA</a>, show a variable sensitivity to levodopa and shows the difference in lesion severity based on location. </p><p>In a study with rats, using <a href="/wiki/Brain_stimulation_reward" title="Brain stimulation reward">intracranial self-stimulation</a> implanted in the medial forebrain bundle, rats treated with <a href="/wiki/Nicotine" title="Nicotine">nicotine</a> and <a href="/wiki/Methamphetamine" title="Methamphetamine">methamphetamine</a> showed an increased speed at which they pressed a lever to induce self-stimulation.<sup id="cite_ref-pmid20975759_12-0" class="reference"><a href="#cite_note-pmid20975759-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> The study indicates that the medial forebrain bundle may be directly linked to motivational behavior that is induced by drugs. </p><p>In a research on rats, the deep brain stimulation (DBS) on the MFB causes an increase in dopamine for 40 seconds which is above baseline but after 40 seconds, it wasn't increased above baseline.<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Medial_forebrain_bundle&action=edit&section=5" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-1">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite id="CITEREFCoenenSchumacherKallerSchlaepfer2018" class="citation journal cs1">Coenen VA, Schumacher LV, Kaller C, Schlaepfer TE, Reinacher PC, Egger K, et al. (2018). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964495">"The anatomy of the human medial forebrain bundle: Ventral tegmental area connections to reward-associated subcortical and frontal lobe regions"</a>. <i>NeuroImage. Clinical</i>. <b>18</b>: 770–783. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.nicl.2018.03.019">10.1016/j.nicl.2018.03.019</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964495">5964495</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/29845013">29845013</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=NeuroImage.+Clinical&rft.atitle=The+anatomy+of+the+human+medial+forebrain+bundle%3A+Ventral+tegmental+area+connections+to+reward-associated+subcortical+and+frontal+lobe+regions&rft.volume=18&rft.pages=770-783&rft.date=2018&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5964495%23id-name%3DPMC&rft_id=info%3Apmid%2F29845013&rft_id=info%3Adoi%2F10.1016%2Fj.nicl.2018.03.019&rft.aulast=Coenen&rft.aufirst=VA&rft.au=Schumacher%2C+LV&rft.au=Kaller%2C+C&rft.au=Schlaepfer%2C+TE&rft.au=Reinacher%2C+PC&rft.au=Egger%2C+K&rft.au=Urbach%2C+H&rft.au=Reisert%2C+M&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5964495&rfr_id=info%3Asid%2Fen.wikipedia.org%3AMedial+forebrain+bundle" class="Z3988"></span></span> </li> <li id="cite_note-pmid11720786-2"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid11720786_2-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFYouChenWise2001" class="citation journal cs1">You ZB, Chen YQ, Wise RA (2001). "Dopamine and glutamate release in the nucleus accumbens and ventral tegmental area of rat following lateral hypothalamic self-stimulation". <i>Neuroscience</i>. <b>107</b> (4): 629–39. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fs0306-4522%2801%2900379-7">10.1016/s0306-4522(01)00379-7</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11720786">11720786</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:33615497">33615497</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Dopamine+and+glutamate+release+in+the+nucleus+accumbens+and+ventral+tegmental+area+of+rat+following+lateral+hypothalamic+self-stimulation&rft.volume=107&rft.issue=4&rft.pages=629-39&rft.date=2001&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A33615497%23id-name%3DS2CID&rft_id=info%3Apmid%2F11720786&rft_id=info%3Adoi%2F10.1016%2Fs0306-4522%2801%2900379-7&rft.aulast=You&rft.aufirst=ZB&rft.au=Chen%2C+YQ&rft.au=Wise%2C+RA&rfr_id=info%3Asid%2Fen.wikipedia.org%3AMedial+forebrain+bundle" class="Z3988"></span></span> </li> <li id="cite_note-Bianco-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-Bianco_3-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBiancoWilson2009" class="citation journal cs1">Bianco IH, Wilson SW (April 2009). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666075">"The habenular nuclei: a conserved asymmetric relay station in the vertebrate brain"</a>. <i>Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences</i>. <b>364</b> (1519): 1005–20. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1098%2Frstb.2008.0213">10.1098/rstb.2008.0213</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666075">2666075</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19064356">19064356</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Philosophical+Transactions+of+the+Royal+Society+of+London.+Series+B%2C+Biological+Sciences&rft.atitle=The+habenular+nuclei%3A+a+conserved+asymmetric+relay+station+in+the+vertebrate+brain&rft.volume=364&rft.issue=1519&rft.pages=1005-20&rft.date=2009-04&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2666075%23id-name%3DPMC&rft_id=info%3Apmid%2F19064356&rft_id=info%3Adoi%2F10.1098%2Frstb.2008.0213&rft.aulast=Bianco&rft.aufirst=IH&rft.au=Wilson%2C+SW&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2666075&rfr_id=info%3Asid%2Fen.wikipedia.org%3AMedial+forebrain+bundle" class="Z3988"></span></span> </li> <li id="cite_note-pmid16893295-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid16893295_4-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHernandezHamdaniRajabiConover2006" class="citation journal cs1">Hernandez G, Hamdani S, Rajabi H, Conover K, Stewart J, Arvanitogiannis A, Shizgal P (August 2006). <a rel="nofollow" class="external text" href="http://content.apa.org/journals/bne/120/4/888">"Prolonged rewarding stimulation of the rat medial forebrain bundle: neurochemical and behavioral consequences"</a>. <i>Behavioral Neuroscience</i>. <b>120</b> (4): 888–904. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1037%2F0735-7044.120.4.888">10.1037/0735-7044.120.4.888</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16893295">16893295</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Behavioral+Neuroscience&rft.atitle=Prolonged+rewarding+stimulation+of+the+rat+medial+forebrain+bundle%3A+neurochemical+and+behavioral+consequences&rft.volume=120&rft.issue=4&rft.pages=888-904&rft.date=2006-08&rft_id=info%3Adoi%2F10.1037%2F0735-7044.120.4.888&rft_id=info%3Apmid%2F16893295&rft.aulast=Hernandez&rft.aufirst=G&rft.au=Hamdani%2C+S&rft.au=Rajabi%2C+H&rft.au=Conover%2C+K&rft.au=Stewart%2C+J&rft.au=Arvanitogiannis%2C+A&rft.au=Shizgal%2C+P&rft_id=http%3A%2F%2Fcontent.apa.org%2Fjournals%2Fbne%2F120%2F4%2F888&rfr_id=info%3Asid%2Fen.wikipedia.org%3AMedial+forebrain+bundle" class="Z3988"></span></span> </li> <li id="cite_note-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-5">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.salon.com/2013/03/23/science_fiction_turns_real_genetically_engineering_animals_for_war/">"Science-fiction turns real: Genetically engineering animals for war"</a>. 23 March 2013.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Science-fiction+turns+real%3A+Genetically+engineering+animals+for+war&rft.date=2013-03-23&rft_id=http%3A%2F%2Fwww.salon.com%2F2013%2F03%2F23%2Fscience_fiction_turns_real_genetically_engineering_animals_for_war%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3AMedial+forebrain+bundle" class="Z3988"></span></span> </li> <li id="cite_note-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-6">^</a></b></span> <span class="reference-text">Carlson. Neil. Physiology of Behavior (11th Edition). Pearson, 2012. Online.</span> </li> <li id="cite_note-pmid21184778-7"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid21184778_7-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCoenenSchlaepferMaedlerPanksepp2011" class="citation journal cs1">Coenen VA, Schlaepfer TE, Maedler B, Panksepp J (October 2011). "Cross-species affective functions of the medial forebrain bundle-implications for the treatment of affective pain and depression in humans". <i>Neuroscience and Biobehavioral Reviews</i>. <b>35</b> (9): 1971–81. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.neubiorev.2010.12.009">10.1016/j.neubiorev.2010.12.009</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/21184778">21184778</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:207088987">207088987</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Neuroscience+and+Biobehavioral+Reviews&rft.atitle=Cross-species+affective+functions+of+the+medial+forebrain+bundle-implications+for+the+treatment+of+affective+pain+and+depression+in+humans&rft.volume=35&rft.issue=9&rft.pages=1971-81&rft.date=2011-10&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A207088987%23id-name%3DS2CID&rft_id=info%3Apmid%2F21184778&rft_id=info%3Adoi%2F10.1016%2Fj.neubiorev.2010.12.009&rft.aulast=Coenen&rft.aufirst=VA&rft.au=Schlaepfer%2C+TE&rft.au=Maedler%2C+B&rft.au=Panksepp%2C+J&rfr_id=info%3Asid%2Fen.wikipedia.org%3AMedial+forebrain+bundle" class="Z3988"></span></span> </li> <li id="cite_note-pmid25530019-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid25530019_8-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFGálvezKeserMwangiGhouse2015" class="citation journal cs1">Gálvez JF, Keser Z, Mwangi B, Ghouse AA, Fenoy AJ, Schulz PE, et al. (April 2015). "The medial forebrain bundle as a deep brain stimulation target for treatment resistant depression: A review of published data". <i>Progress in Neuro-Psychopharmacology & Biological Psychiatry</i>. <b>58</b>: 59–70. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.pnpbp.2014.12.003">10.1016/j.pnpbp.2014.12.003</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25530019">25530019</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:42111037">42111037</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Progress+in+Neuro-Psychopharmacology+%26+Biological+Psychiatry&rft.atitle=The+medial+forebrain+bundle+as+a+deep+brain+stimulation+target+for+treatment+resistant+depression%3A+A+review+of+published+data&rft.volume=58&rft.pages=59-70&rft.date=2015-04&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A42111037%23id-name%3DS2CID&rft_id=info%3Apmid%2F25530019&rft_id=info%3Adoi%2F10.1016%2Fj.pnpbp.2014.12.003&rft.aulast=G%C3%A1lvez&rft.aufirst=JF&rft.au=Keser%2C+Z&rft.au=Mwangi%2C+B&rft.au=Ghouse%2C+AA&rft.au=Fenoy%2C+AJ&rft.au=Schulz%2C+PE&rft.au=Sanches%2C+M&rft.au=Quevedo%2C+J&rft.au=Selvaraj%2C+S&rft.au=Gajwani%2C+P&rft.au=Zunta-Soares%2C+G&rft.au=Hasan%2C+KM&rft.au=Soares%2C+JC&rfr_id=info%3Asid%2Fen.wikipedia.org%3AMedial+forebrain+bundle" class="Z3988"></span></span> </li> <li id="cite_note-9"><span class="mw-cite-backlink"><b><a href="#cite_ref-9">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFHaberTangChoiYendiki2020" class="citation journal cs1">Haber, Suzanne N.; Tang, Wei; Choi, Eun Young; <a href="/wiki/Anastasia_Yendiki" title="Anastasia Yendiki">Yendiki, Anastasia</a>; Liu, Hesheng; Jbabdi, Saad; Versace, Amelia; Phillips, Mary (February 2020). <a rel="nofollow" class="external text" href="https://linkinghub.elsevier.com/retrieve/pii/S000632231931827X">"Circuits, Networks, and Neuropsychiatric Disease: Transitioning From Anatomy to Imaging"</a>. <i>Biological Psychiatry</i>. <b>87</b> (4): 318–327. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.biopsych.2019.10.024">10.1016/j.biopsych.2019.10.024</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biological+Psychiatry&rft.atitle=Circuits%2C+Networks%2C+and+Neuropsychiatric+Disease%3A+Transitioning+From+Anatomy+to+Imaging&rft.volume=87&rft.issue=4&rft.pages=318-327&rft.date=2020-02&rft_id=info%3Adoi%2F10.1016%2Fj.biopsych.2019.10.024&rft.aulast=Haber&rft.aufirst=Suzanne+N.&rft.au=Tang%2C+Wei&rft.au=Choi%2C+Eun+Young&rft.au=Yendiki%2C+Anastasia&rft.au=Liu%2C+Hesheng&rft.au=Jbabdi%2C+Saad&rft.au=Versace%2C+Amelia&rft.au=Phillips%2C+Mary&rft_id=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS000632231931827X&rfr_id=info%3Asid%2Fen.wikipedia.org%3AMedial+forebrain+bundle" class="Z3988"></span></span> </li> <li id="cite_note-10"><span class="mw-cite-backlink"><b><a href="#cite_ref-10">^</a></b></span> <span class="reference-text">Negus SS, Miller LL. Intracranial self-stimulation to evaluate potential abuse of drugs. "Pharmocol Rev." 66.3 (2014):869-917. Online</span> </li> <li id="cite_note-pmid24262181-11"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid24262181_11-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFFrancardoCenci2014" class="citation journal cs1 cs1-prop-long-vol">Francardo V, Cenci MA (January 2014). "Investigating the molecular mechanisms of L-DOPA-induced dyskinesia in the mouse". <i>Parkinsonism & Related Disorders</i>. 20 Suppl 1: S20-2. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FS1353-8020%2813%2970008-7">10.1016/S1353-8020(13)70008-7</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24262181">24262181</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Parkinsonism+%26+Related+Disorders&rft.atitle=Investigating+the+molecular+mechanisms+of+L-DOPA-induced+dyskinesia+in+the+mouse&rft.volume=20+Suppl+1&rft.pages=S20-2&rft.date=2014-01&rft_id=info%3Adoi%2F10.1016%2FS1353-8020%2813%2970008-7&rft_id=info%3Apmid%2F24262181&rft.aulast=Francardo&rft.aufirst=V&rft.au=Cenci%2C+MA&rfr_id=info%3Asid%2Fen.wikipedia.org%3AMedial+forebrain+bundle" class="Z3988"></span></span> </li> <li id="cite_note-pmid20975759-12"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid20975759_12-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFSagaraSendoGomita2010" class="citation journal cs1">Sagara H, Sendo T, Gomita Y (October 2010). "Evaluation of motivational effects induced by intracranial self-stimulation behavior". <i>Acta Medica Okayama</i>. <b>64</b> (5): 267–75. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.18926%2FAMO%2F40501">10.18926/AMO/40501</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20975759">20975759</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Acta+Medica+Okayama&rft.atitle=Evaluation+of+motivational+effects+induced+by+intracranial+self-stimulation+behavior&rft.volume=64&rft.issue=5&rft.pages=267-75&rft.date=2010-10&rft_id=info%3Adoi%2F10.18926%2FAMO%2F40501&rft_id=info%3Apmid%2F20975759&rft.aulast=Sagara&rft.aufirst=H&rft.au=Sendo%2C+T&rft.au=Gomita%2C+Y&rfr_id=info%3Asid%2Fen.wikipedia.org%3AMedial+forebrain+bundle" class="Z3988"></span></span> </li> <li id="cite_note-13"><span class="mw-cite-backlink"><b><a href="#cite_ref-13">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKlankerFeenstraWilluhnDenys2017" class="citation journal cs1">Klanker M, Feenstra M, Willuhn I, Denys D (November 2017). "Deep brain stimulation of the medial forebrain bundle elevates striatal dopamine concentration without affecting spontaneous or reward-induced phasic release". <i>Neuroscience</i>. <b>364</b>: 82–92. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.neuroscience.2017.09.012">10.1016/j.neuroscience.2017.09.012</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/28918253">28918253</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:27319522">27319522</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Deep+brain+stimulation+of+the+medial+forebrain+bundle+elevates+striatal+dopamine+concentration+without+affecting+spontaneous+or+reward-induced+phasic+release&rft.volume=364&rft.pages=82-92&rft.date=2017-11&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A27319522%23id-name%3DS2CID&rft_id=info%3Apmid%2F28918253&rft_id=info%3Adoi%2F10.1016%2Fj.neuroscience.2017.09.012&rft.aulast=Klanker&rft.aufirst=M&rft.au=Feenstra%2C+M&rft.au=Willuhn%2C+I&rft.au=Denys%2C+D&rfr_id=info%3Asid%2Fen.wikipedia.org%3AMedial+forebrain+bundle" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Medial_forebrain_bundle&action=edit&section=6" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="http://www.thebrain.mcgill.ca/flash/i/i_03/i_03_cl/i_03_cl_que/i_03_cl_que.html">Overview at thebrain.mcgill.ca</a></li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline ul,.mw-parser-output .hlist dl dl,.mw-parser-output .hlist dl ol,.mw-parser-output .hlist dl ul,.mw-parser-output .hlist ol dl,.mw-parser-output .hlist ol ol,.mw-parser-output .hlist ol ul,.mw-parser-output .hlist ul dl,.mw-parser-output .hlist ul ol,.mw-parser-output .hlist ul ul{display:inline}.mw-parser-output .hlist .mw-empty-li{display:none}.mw-parser-output .hlist dt::after{content:": "}.mw-parser-output .hlist dd::after,.mw-parser-output .hlist li::after{content:" · ";font-weight:bold}.mw-parser-output .hlist dd:last-child::after,.mw-parser-output .hlist dt:last-child::after,.mw-parser-output .hlist li:last-child::after{content:none}.mw-parser-output .hlist dd dd:first-child::before,.mw-parser-output .hlist dd dt:first-child::before,.mw-parser-output .hlist dd li:first-child::before,.mw-parser-output .hlist dt dd:first-child::before,.mw-parser-output .hlist dt dt:first-child::before,.mw-parser-output .hlist dt li:first-child::before,.mw-parser-output .hlist li dd:first-child::before,.mw-parser-output .hlist li dt:first-child::before,.mw-parser-output .hlist li li:first-child::before{content:" (";font-weight:normal}.mw-parser-output .hlist dd dd:last-child::after,.mw-parser-output .hlist dd dt:last-child::after,.mw-parser-output .hlist dd li:last-child::after,.mw-parser-output .hlist dt dd:last-child::after,.mw-parser-output .hlist dt dt:last-child::after,.mw-parser-output .hlist dt li:last-child::after,.mw-parser-output .hlist li dd:last-child::after,.mw-parser-output .hlist li dt:last-child::after,.mw-parser-output .hlist li li:last-child::after{content:")";font-weight:normal}.mw-parser-output .hlist ol{counter-reset:listitem}.mw-parser-output .hlist ol>li{counter-increment:listitem}.mw-parser-output .hlist ol>li::before{content:" "counter(listitem)"\a0 "}.mw-parser-output .hlist dd ol>li:first-child::before,.mw-parser-output .hlist dt ol>li:first-child::before,.mw-parser-output .hlist li ol>li:first-child::before{content:" ("counter(listitem)"\a0 "}</style><style data-mw-deduplicate="TemplateStyles:r1236075235">.mw-parser-output .navbox{box-sizing:border-box;border:1px solid #a2a9b1;width:100%;clear:both;font-size:88%;text-align:center;padding:1px;margin:1em auto 0}.mw-parser-output .navbox .navbox{margin-top:0}.mw-parser-output .navbox+.navbox,.mw-parser-output .navbox+.navbox-styles+.navbox{margin-top:-1px}.mw-parser-output .navbox-inner,.mw-parser-output .navbox-subgroup{width:100%}.mw-parser-output .navbox-group,.mw-parser-output .navbox-title,.mw-parser-output .navbox-abovebelow{padding:0.25em 1em;line-height:1.5em;text-align:center}.mw-parser-output .navbox-group{white-space:nowrap;text-align:right}.mw-parser-output .navbox,.mw-parser-output .navbox-subgroup{background-color:#fdfdfd}.mw-parser-output .navbox-list{line-height:1.5em;border-color:#fdfdfd}.mw-parser-output .navbox-list-with-group{text-align:left;border-left-width:2px;border-left-style:solid}.mw-parser-output tr+tr>.navbox-abovebelow,.mw-parser-output tr+tr>.navbox-group,.mw-parser-output tr+tr>.navbox-image,.mw-parser-output tr+tr>.navbox-list{border-top:2px solid #fdfdfd}.mw-parser-output .navbox-title{background-color:#ccf}.mw-parser-output .navbox-abovebelow,.mw-parser-output .navbox-group,.mw-parser-output .navbox-subgroup .navbox-title{background-color:#ddf}.mw-parser-output .navbox-subgroup .navbox-group,.mw-parser-output .navbox-subgroup .navbox-abovebelow{background-color:#e6e6ff}.mw-parser-output .navbox-even{background-color:#f7f7f7}.mw-parser-output .navbox-odd{background-color:transparent}.mw-parser-output .navbox .hlist td dl,.mw-parser-output .navbox .hlist td ol,.mw-parser-output .navbox .hlist td ul,.mw-parser-output .navbox td.hlist dl,.mw-parser-output .navbox td.hlist ol,.mw-parser-output .navbox td.hlist ul{padding:0.125em 0}.mw-parser-output .navbox .navbar{display:block;font-size:100%}.mw-parser-output .navbox-title .navbar{float:left;text-align:left;margin-right:0.5em}body.skin--responsive .mw-parser-output .navbox-image img{max-width:none!important}@media print{body.ns-0 .mw-parser-output .navbox{display:none!important}}</style></div><div role="navigation" class="navbox" aria-labelledby="Anatomy_of_the_diencephalon_of_the_human_brain" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><style data-mw-deduplicate="TemplateStyles:r1239400231">.mw-parser-output .navbar{display:inline;font-size:88%;font-weight:normal}.mw-parser-output .navbar-collapse{float:left;text-align:left}.mw-parser-output .navbar-boxtext{word-spacing:0}.mw-parser-output .navbar ul{display:inline-block;white-space:nowrap;line-height:inherit}.mw-parser-output .navbar-brackets::before{margin-right:-0.125em;content:"[ "}.mw-parser-output .navbar-brackets::after{margin-left:-0.125em;content:" ]"}.mw-parser-output .navbar li{word-spacing:-0.125em}.mw-parser-output .navbar a>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}html.skin-theme-clientpref-night .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}@media(prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .navbar li a abbr{color:var(--color-base)!important}}@media print{.mw-parser-output .navbar{display:none!important}}</style><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Diencephalon" title="Template:Diencephalon"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Diencephalon" title="Template talk:Diencephalon"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Diencephalon" title="Special:EditPage/Template:Diencephalon"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Anatomy_of_the_diencephalon_of_the_human_brain" style="font-size:114%;margin:0 4em">Anatomy of the <a href="/wiki/Diencephalon" title="Diencephalon">diencephalon</a> of the <a href="/wiki/Human_brain" title="Human brain">human brain</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Epithalamus" title="Epithalamus">Epithalamus</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Surface</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Pineal_gland" title="Pineal gland">Pineal gland</a></li> <li><a href="/wiki/Habenula" title="Habenula">Habenula</a></li> <li><a href="/wiki/Habenular_trigone" title="Habenular trigone">Habenular trigone</a></li> <li><a href="/wiki/Habenular_commissure" title="Habenular commissure">Habenular commissure</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Grey_matter" title="Grey matter">Grey matter</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Pretectal_area" title="Pretectal area">Pretectal area</a></li> <li><a href="/wiki/Habenular_nuclei" class="mw-redirect" title="Habenular nuclei">Habenular nuclei</a></li> <li><a href="/wiki/Subcommissural_organ" title="Subcommissural organ">Subcommissural organ</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Thalamus" title="Thalamus">Thalamus</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Surface</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Stria_medullaris" title="Stria medullaris">Stria medullaris</a></li> <li><a href="/wiki/Thalamic_reticular_nucleus" title="Thalamic reticular nucleus">Thalamic reticular nucleus</a></li> <li><a href="/wiki/Taenia_thalami" title="Taenia thalami">Taenia thalami</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Grey_matter" title="Grey matter">Grey matter</a>/<br /><a href="/wiki/List_of_thalamic_nuclei" title="List of thalamic nuclei">nuclei</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>paired:</i> <a href="/wiki/Anterior_nuclei_of_thalamus" title="Anterior nuclei of thalamus">AN</a></li> <li><a href="/wiki/Ventral_nuclear_group" title="Ventral nuclear group">Ventral</a> <ul><li><a href="/wiki/Ventral_anterior_nucleus" title="Ventral anterior nucleus">VA</a>/<a href="/wiki/Ventral_lateral_nucleus" title="Ventral lateral nucleus">VL</a></li> <li><a href="/wiki/Ventral_posterior_nucleus" title="Ventral posterior nucleus">VP</a>/<a href="/wiki/Ventral_posteromedial_nucleus" title="Ventral posteromedial nucleus">VPM</a>/<a href="/wiki/Ventral_posterolateral_nucleus" title="Ventral posterolateral nucleus">VPL</a></li></ul></li> <li><a href="/wiki/Lateral_nuclear_group" title="Lateral nuclear group">Lateral</a> <ul><li><a href="/wiki/Lateral_dorsal_nucleus_of_thalamus" title="Lateral dorsal nucleus of thalamus">LD</a></li> <li><a href="/wiki/Lateral_posterior_nucleus_of_thalamus" title="Lateral posterior nucleus of thalamus">LP</a></li> <li><a href="/wiki/Pulvinar_nuclei" title="Pulvinar nuclei">Pulvinar nuclei</a></li></ul></li> <li><a href="/wiki/Metathalamus" class="mw-redirect" title="Metathalamus">Metathalamus</a> <ul><li><a href="/wiki/Medial_geniculate_nucleus" title="Medial geniculate nucleus">MG</a></li> <li><a href="/wiki/Lateral_geniculate_nucleus" title="Lateral geniculate nucleus">LG</a> <ul><li><a href="/wiki/Parvocellular_cell" title="Parvocellular cell">P cell</a></li> <li><a href="/wiki/Magnocellular_cell" title="Magnocellular cell">M cell</a></li> <li><a href="/wiki/Koniocellular_cell" title="Koniocellular cell">K cell</a></li></ul></li></ul></li></ul> <ul><li><i>midline:</i> <a href="/wiki/Medial_dorsal_nucleus" title="Medial dorsal nucleus">MD</a></li> <li><a href="/wiki/Intralaminar_nuclei_of_thalamus" class="mw-redirect" title="Intralaminar nuclei of thalamus">Intralaminar</a> <ul><li><a href="/wiki/Centromedian_nucleus" title="Centromedian nucleus">Centromedian</a></li></ul></li> <li><a href="/wiki/Midline_nuclear_group" title="Midline nuclear group">Midline nuclear group</a></li> <li><a href="/wiki/Interthalamic_adhesion" title="Interthalamic adhesion">Interthalamic adhesion</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/White_matter" title="White matter">White matter</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Mammillothalamic_tract" title="Mammillothalamic tract">Mammillothalamic tract</a></li> <li><a href="/wiki/Pallidothalamic_tracts" title="Pallidothalamic tracts">Pallidothalamic tracts</a> <ul><li><a href="/wiki/Ansa_lenticularis" title="Ansa lenticularis">Ansa lenticularis</a></li> <li><a href="/wiki/Lenticular_fasciculus" title="Lenticular fasciculus">Lenticular fasciculus</a></li> <li><a href="/wiki/Thalamic_fasciculus" title="Thalamic fasciculus">Thalamic fasciculus</a></li></ul></li> <li><i><a href="/wiki/Dorsal_column-medial_lemniscus_pathway" class="mw-redirect" title="Dorsal column-medial lemniscus pathway">DCML</a></i> <ul><li><a href="/wiki/Medial_lemniscus" title="Medial lemniscus">Medial lemniscus</a></li> <li><a href="/wiki/Trigeminal_lemniscus" title="Trigeminal lemniscus">Trigeminal lemniscus</a></li></ul></li> <li><a href="/wiki/Spinothalamic_tract" title="Spinothalamic tract">Spinothalamic tract</a></li> <li><a href="/wiki/Lateral_lemniscus" title="Lateral lemniscus">Lateral lemniscus</a></li> <li><a href="/wiki/Dentatothalamic_tract" title="Dentatothalamic tract">Dentatothalamic tract</a></li> <li><a href="/wiki/Acoustic_radiation" title="Acoustic radiation">Acoustic radiation</a></li> <li><a href="/wiki/Optic_radiation" title="Optic radiation">Optic radiation</a></li> <li><a href="/wiki/Subthalamic_fasciculus" title="Subthalamic fasciculus">Subthalamic fasciculus</a></li> <li><a href="/wiki/Ventral_trigeminal_tract" title="Ventral trigeminal tract">Ventral trigeminal tract</a></li></ul> <ul><li><a href="/wiki/Medullary_laminae_of_thalamus" title="Medullary laminae of thalamus">Medullary laminae</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Hypothalamus" title="Hypothalamus">Hypothalamus</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">Surface</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Median_eminence" title="Median eminence">Median eminence</a>/<a href="/wiki/Tuber_cinereum" title="Tuber cinereum">Tuber cinereum</a></li> <li><a href="/wiki/Mammillary_body" title="Mammillary body">Mammillary body</a></li> <li><a href="/wiki/Pituitary_stalk" title="Pituitary stalk">Infundibulum</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Grey_matter" title="Grey matter">Grey matter</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Autonomic_nervous_system" title="Autonomic nervous system">Autonomic</a> zones</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Anterior_hypothalamic_nucleus" title="Anterior hypothalamic nucleus">Anterior (parasympathetic/heat loss)</a></li> <li><a href="/wiki/Posterior_nucleus_of_hypothalamus" title="Posterior nucleus of hypothalamus">Posterior (sympathetic/heat conservation)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Endocrine_system" title="Endocrine system">Endocrine</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Posterior_pituitary" title="Posterior pituitary">posterior pituitary</a>:</i> <a href="/wiki/Paraventricular_nucleus_of_hypothalamus" title="Paraventricular nucleus of hypothalamus">Paraventricular</a> <ul><li><a href="/wiki/Magnocellular_neurosecretory_cell" title="Magnocellular neurosecretory cell">Magnocellular neurosecretory cell</a></li> <li><a href="/wiki/Parvocellular_neurosecretory_cell" title="Parvocellular neurosecretory cell">Parvocellular neurosecretory cell</a></li></ul></li> <li><a href="/wiki/Supraoptic_nucleus" title="Supraoptic nucleus">Supraoptic</a> <ul><li><a href="/wiki/Oxytocin" title="Oxytocin">oxytocin</a>/<a href="/wiki/Vasopressin" title="Vasopressin">vasopressin</a></li></ul></li></ul> <ul><li><i>other:</i> <a href="/wiki/Arcuate_nucleus_(hypothalamus)" title="Arcuate nucleus (hypothalamus)">Arcuate (dopamine/GHRH)</a></li> <li><a href="/wiki/Preoptic_area" title="Preoptic area">Preoptic (GnRH)</a></li> <li><a href="/wiki/Suprachiasmatic_nucleus" title="Suprachiasmatic nucleus">Suprachiasmatic (melatonin)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Emotion" title="Emotion">Emotion</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Lateral_hypothalamus" title="Lateral hypothalamus">Lateral</a></li> <li><a href="/wiki/Ventromedial_nucleus" class="mw-redirect" title="Ventromedial nucleus">Ventromedial</a></li> <li><a href="/wiki/Dorsomedial_hypothalamic_nucleus" title="Dorsomedial hypothalamic nucleus">Dorsomedial</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/White_matter" title="White matter">White matter</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>afferent</i> <ul><li><a href="/wiki/Stria_terminalis" title="Stria terminalis">Stria terminalis</a></li> <li><a class="mw-selflink selflink">Medial forebrain bundle</a></li> <li><a href="/wiki/Retinohypothalamic_tract" title="Retinohypothalamic tract">Retinohypothalamic tract</a></li></ul></li> <li><i>efferent</i> <ul><li><a href="/wiki/Mammillothalamic_tract" title="Mammillothalamic tract">Mammillothalamic tract</a></li> <li><a href="/wiki/Dorsal_longitudinal_fasciculus" title="Dorsal longitudinal fasciculus">Dorsal longitudinal fasciculus</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Pituitary_gland" title="Pituitary gland">Pituitary</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Posterior_pituitary" title="Posterior pituitary">Posterior</a> is diencephalon, but <a href="/wiki/Anterior_pituitary" title="Anterior pituitary">anterior</a> is glandular</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Subthalamus" title="Subthalamus">Subthalamus</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Subthalamic_nucleus" title="Subthalamic nucleus">Subthalamic nucleus</a></li> <li><a href="/wiki/Zona_incerta" title="Zona incerta">Zona incerta</a></li> <li><a href="/wiki/Nuclei_campi_perizonalis" class="mw-redirect" title="Nuclei campi perizonalis">Nuclei campi perizonalis</a> (<a href="/wiki/Fields_of_Forel" title="Fields of Forel">Fields of Forel</a>)</li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Smell" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Olfactory_system" title="Template:Olfactory system"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Olfactory_system" title="Template talk:Olfactory system"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Olfactory_system" title="Special:EditPage/Template:Olfactory system"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Smell" style="font-size:114%;margin:0 4em"><a href="/wiki/Sense_of_smell" title="Sense of smell">Smell</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Microanatomy</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Olfactory_epithelium" title="Olfactory epithelium">Epithelium</a> <ul><li><a href="/wiki/Olfactory_glands" title="Olfactory glands">glands</a></li> <li><a href="/wiki/Olfactory_mucosa" title="Olfactory mucosa">mucosa</a></li></ul></li> <li><a href="/wiki/Sustentacular_cell" title="Sustentacular cell">Sustentacular cell</a></li> <li><a href="/wiki/Tufted_cell" title="Tufted cell">Tufted cell</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Olfactory_nerve" title="Olfactory nerve">Olfactory nerve</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Olfactory_receptor" title="Olfactory receptor">Olfactory receptor</a> <ul><li><a href="/wiki/Olfactory_receptor_neuron" title="Olfactory receptor neuron">neuron</a></li></ul></li> <li><a href="/wiki/Olfactory_bulb" title="Olfactory bulb">Olfactory bulb</a> <ul><li><a href="/wiki/Glomerulus_(olfaction)" title="Glomerulus (olfaction)">glomeruli</a></li> <li><a href="/wiki/Olfactory_bulb_mitral_cell" class="mw-redirect" title="Olfactory bulb mitral cell">mitral cells</a></li></ul></li> <li><a href="/wiki/Olfactory_tract" title="Olfactory tract">Olfactory tract</a></li> <li><a href="/wiki/Olfactory_trigone" title="Olfactory trigone">Olfactory trigone</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Brain" title="Brain">Brain</a> areas involved in smell</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><a href="/wiki/Primary_olfactory_cortex" title="Primary olfactory cortex">Primary olfactory cortex</a></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Lateral_olfactory_stria" class="mw-redirect" title="Lateral olfactory stria">Lateral olfactory stria</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">1</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Piriform_cortex" title="Piriform cortex">Piriform cortex</a></li> <li><a href="/wiki/EC-hippocampus_system" title="EC-hippocampus system">EC-hippocampus system</a> <ul><li><a href="/wiki/Entorhinal_cortex" title="Entorhinal cortex">Entorhinal cortex</a></li> <li><a href="/wiki/Hippocampal_formation" title="Hippocampal formation">Hippocampal formation</a></li></ul></li> <li><a href="/wiki/Prepyriform_area" title="Prepyriform area">Prepyriform area</a></li> <li><a href="/wiki/Periamygdaloid_cortex" title="Periamygdaloid cortex">Periamygdaloid cortex</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">2</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Stria_medullaris" title="Stria medullaris">Stria medullaris</a> → <a href="/wiki/Habenular_nuclei" class="mw-redirect" title="Habenular nuclei">Habenular nuclei</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">3</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Amygdala" title="Amygdala">Amygdala</a> → <a href="/wiki/Stria_terminalis" title="Stria terminalis">Stria terminalis</a> → <a href="/wiki/Hypothalamus" title="Hypothalamus">Hypothalamus</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">4</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a class="mw-selflink selflink">Medial forebrain bundle</a> → <a href="/wiki/Hypothalamus" title="Hypothalamus">Hypothalamus</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Medial_olfactory_stria" class="mw-redirect" title="Medial olfactory stria">Medial olfactory stria</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Anterior_olfactory_nucleus" title="Anterior olfactory nucleus">Anterior olfactory nucleus</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">General</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Odor" title="Odor">Odor</a></li> <li><a href="/wiki/Olfactory_system" title="Olfactory system">Olfactory system</a></li> <li><a href="/wiki/Evolution_of_olfaction" title="Evolution of olfaction">Evolution of olfaction</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox authority-control" aria-label="Navbox" style="padding:3px"><table class="nowraplinks hlist navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Help:Authority_control" title="Help:Authority control">Authority control databases</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q4287680#identifiers" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><ul><li><span class="uid"><a class="external text" href="http://tools.wmflabs.org/wikidata-externalid-url/?p=1323&url_prefix=https:%2F%2Fwww.unifr.ch%2Fifaa%2FPublic%2FEntryPage%2FTA98%20Tree%2FEntity%20TA98%20EN%2F&url_suffix=%20Entity%20TA98%20EN.htm&id=A14.1.08.955">Terminologia Anatomica</a></span></li></ul></div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?useformat=desktop&type=1x1&usesul3=0" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div class="printfooter" data-nosnippet="">Retrieved from "<a dir="ltr" href="https://en.wikipedia.org/w/index.php?title=Medial_forebrain_bundle&oldid=1257690665">https://en.wikipedia.org/w/index.php?title=Medial_forebrain_bundle&oldid=1257690665</a>"</div></div> <div id="catlinks" class="catlinks" data-mw="interface"><div id="mw-normal-catlinks" class="mw-normal-catlinks"><a href="/wiki/Help:Category" title="Help:Category">Categories</a>: <ul><li><a href="/wiki/Category:Neuroanatomy" title="Category:Neuroanatomy">Neuroanatomy</a></li><li><a href="/wiki/Category:Olfactory_system" title="Category:Olfactory system">Olfactory system</a></li></ul></div><div id="mw-hidden-catlinks" class="mw-hidden-catlinks mw-hidden-cats-hidden">Hidden category: <ul><li><a href="/wiki/Category:CS1:_long_volume_value" title="Category:CS1: long volume value">CS1: long volume value</a></li></ul></div></div> </div> </main> </div> <div class="mw-footer-container"> <footer id="footer" class="mw-footer" > <ul id="footer-info"> <li id="footer-info-lastmod"> This page was last edited on 16 November 2024, at 05:18<span class="anonymous-show"> (UTC)</span>.</li> <li id="footer-info-copyright">Text is available under the <a href="/wiki/Wikipedia:Text_of_the_Creative_Commons_Attribution-ShareAlike_4.0_International_License" title="Wikipedia:Text of the Creative Commons Attribution-ShareAlike 4.0 International License">Creative Commons Attribution-ShareAlike 4.0 License</a>; additional terms may apply. By using this site, you agree to the <a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Terms_of_Use" class="extiw" title="foundation:Special:MyLanguage/Policy:Terms of Use">Terms of Use</a> and <a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Privacy_policy" class="extiw" title="foundation:Special:MyLanguage/Policy:Privacy policy">Privacy Policy</a>. Wikipedia® is a registered trademark of the <a rel="nofollow" class="external text" href="https://wikimediafoundation.org/">Wikimedia Foundation, Inc.</a>, a non-profit organization.</li> </ul> <ul id="footer-places"> <li id="footer-places-privacy"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Privacy_policy">Privacy policy</a></li> <li id="footer-places-about"><a href="/wiki/Wikipedia:About">About Wikipedia</a></li> <li id="footer-places-disclaimers"><a href="/wiki/Wikipedia:General_disclaimer">Disclaimers</a></li> <li id="footer-places-contact"><a href="//en.wikipedia.org/wiki/Wikipedia:Contact_us">Contact Wikipedia</a></li> <li id="footer-places-wm-codeofconduct"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Universal_Code_of_Conduct">Code of Conduct</a></li> <li id="footer-places-developers"><a href="https://developer.wikimedia.org">Developers</a></li> <li id="footer-places-statslink"><a href="https://stats.wikimedia.org/#/en.wikipedia.org">Statistics</a></li> <li id="footer-places-cookiestatement"><a href="https://foundation.wikimedia.org/wiki/Special:MyLanguage/Policy:Cookie_statement">Cookie statement</a></li> <li id="footer-places-mobileview"><a href="//en.m.wikipedia.org/w/index.php?title=Medial_forebrain_bundle&mobileaction=toggle_view_mobile" class="noprint stopMobileRedirectToggle">Mobile view</a></li> </ul> <ul id="footer-icons" class="noprint"> <li id="footer-copyrightico"><a href="https://wikimediafoundation.org/" class="cdx-button cdx-button--fake-button cdx-button--size-large cdx-button--fake-button--enabled"><img src="/static/images/footer/wikimedia-button.svg" width="84" height="29" alt="Wikimedia Foundation" loading="lazy"></a></li> <li id="footer-poweredbyico"><a href="https://www.mediawiki.org/" class="cdx-button cdx-button--fake-button cdx-button--size-large cdx-button--fake-button--enabled"><img src="/w/resources/assets/poweredby_mediawiki.svg" alt="Powered by MediaWiki" width="88" height="31" loading="lazy"></a></li> </ul> </footer> </div> </div> </div> <div class="vector-settings" id="p-dock-bottom"> <ul></ul> </div><script>(RLQ=window.RLQ||[]).push(function(){mw.config.set({"wgHostname":"mw-web.codfw.main-7f966856f8-64kls","wgBackendResponseTime":124,"wgPageParseReport":{"limitreport":{"cputime":"0.432","walltime":"0.685","ppvisitednodes":{"value":1779,"limit":1000000},"postexpandincludesize":{"value":98460,"limit":2097152},"templateargumentsize":{"value":854,"limit":2097152},"expansiondepth":{"value":10,"limit":100},"expensivefunctioncount":{"value":1,"limit":500},"unstrip-depth":{"value":1,"limit":20},"unstrip-size":{"value":68130,"limit":5000000},"entityaccesscount":{"value":1,"limit":400},"timingprofile":["100.00% 607.731 1 -total"," 39.75% 241.546 1 Template:Infobox_brain"," 39.05% 237.311 1 Template:Infobox_anatomy"," 37.60% 228.519 1 Template:Infobox"," 32.93% 200.116 1 Template:Reflist"," 25.44% 154.612 10 Template:Cite_journal"," 18.70% 113.674 8 Template:Navbox"," 16.22% 98.600 1 Template:Diencephalon"," 5.75% 34.920 1 Template:Olfactory_system"," 3.81% 23.156 1 Template:Authority_control"]},"scribunto":{"limitreport-timeusage":{"value":"0.269","limit":"10.000"},"limitreport-memusage":{"value":4970973,"limit":52428800}},"cachereport":{"origin":"mw-web.eqiad.main-7d8886d77d-cb9v7","timestamp":"20241219114804","ttl":2592000,"transientcontent":false}}});});</script> <script type="application/ld+json">{"@context":"https:\/\/schema.org","@type":"Article","name":"Medial forebrain bundle","url":"https:\/\/en.wikipedia.org\/wiki\/Medial_forebrain_bundle","sameAs":"http:\/\/www.wikidata.org\/entity\/Q4287680","mainEntity":"http:\/\/www.wikidata.org\/entity\/Q4287680","author":{"@type":"Organization","name":"Contributors to Wikimedia projects"},"publisher":{"@type":"Organization","name":"Wikimedia Foundation, Inc.","logo":{"@type":"ImageObject","url":"https:\/\/www.wikimedia.org\/static\/images\/wmf-hor-googpub.png"}},"datePublished":"2006-05-12T21:04:31Z","dateModified":"2024-11-16T05:18:41Z","image":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/b\/be\/Medial_Forebrain_Bundle.jpg","headline":"complex group of fibers in the brain arising from the basal olfactory regions, the periamygdaloid region and the septal nuclei"}</script> </body> </html>