CINXE.COM

<!DOCTYPE html> <html > <head> <meta charset="utf-8"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <meta content="width=device-width, initial-scale=1" name="viewport"> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs"> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="r14HFs7EXjMd4H31FWLJs9H4SvIDzoI0t3N9zgDl8sZGn89hJ3LoXkMHmtUhP0wvcu9aVUTAunK7+F9GzdDAbQ==" /> <meta name="citation_title" content="Glucagon-Like Peptide 1 Stimulates Lipolysis in Clonal Pancreatic �Cells (HIT)" /> <meta name="citation_publication_date" content="2001/01/01" /> <meta name="citation_journal_title" content="Diabetes" /> <meta name="citation_author" content="Barbara Corkey" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:url" content="https://www.academia.edu/53418007/Glucagon_Like_Peptide_1_Stimulates_Lipolysis_in_Clonal_Pancreatic_Cells_HIT_" /> <meta name="twitter:title" content="Glucagon-Like Peptide 1 Stimulates Lipolysis in Clonal Pancreatic �Cells (HIT)" /> <meta name="twitter:description" content="Academia.edu is a platform for academics to share research papers." /> <meta name="twitter:image" content="http://a.academia-assets.com/images/twitter-card.jpeg" /> <meta property="fb:app_id" content="2369844204" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.academia.edu/53418007/Glucagon_Like_Peptide_1_Stimulates_Lipolysis_in_Clonal_Pancreatic_Cells_HIT_" /> <meta property="og:title" content="Glucagon-Like Peptide 1 Stimulates Lipolysis in Clonal Pancreatic �Cells (HIT)" /> <meta property="og:image" content="http://a.academia-assets.com/images/open-graph-icons/fb-paper.gif" /> <meta property="og:description" content="Glucagon-Like Peptide 1 Stimulates Lipolysis in Clonal Pancreatic �Cells (HIT)" /> <meta property="article:author" content="https://upenn.academia.edu/BarbaraCorkey" /> <meta name="description" content="Glucagon-Like Peptide 1 Stimulates Lipolysis in Clonal Pancreatic �Cells (HIT)" /> <title>(PDF) Glucagon-Like Peptide 1 Stimulates Lipolysis in Clonal Pancreatic �Cells (HIT) | Barbara Corkey - Academia.edu</title> <link rel="canonical" href="https://www.academia.edu/53418007/Glucagon_Like_Peptide_1_Stimulates_Lipolysis_in_Clonal_Pancreatic_Cells_HIT_" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = '9387f500ddcbb8d05c67bef28a2fe0334f1aafb8'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1733055780000); window.Aedu.timeDifference = new Date().getTime() - 1733055780000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","abstract":null,"author":[{"@context":"https://schema.org","@type":"Person","name":"Barbara Corkey"}],"contributor":[],"dateCreated":"2021-09-26","dateModified":null,"datePublished":"2001-01-01","headline":"Glucagon-Like Peptide 1 Stimulates Lipolysis in Clonal Pancreatic �Cells (HIT)","inLanguage":"en","keywords":["Diabetes","Calcium","Enzyme Inhibitors","Cell line","In Vitro","Glucagon","Insulin Secretion","Lipolysis","Stimulation","Mechanism of action","Free Fatty Acid","Cell Surface Markers","Hydrogen-Ion Concentration","Lipase","Lactones","islets of Langerhans","Medical and Health Sciences"],"locationCreated":null,"publication":"Diabetes","publisher":{"@context":"https://schema.org","@type":"Organization","name":null},"image":null,"thumbnailUrl":null,"url":"https://www.academia.edu/53418007/Glucagon_Like_Peptide_1_Stimulates_Lipolysis_in_Clonal_Pancreatic_Cells_HIT_","sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":"upenn"}]}</script><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/single_work_page/loswp-102fa537001ba4d8dcd921ad9bd56c474abc201906ea4843e7e7efe9dfbf561d.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/body-8d679e925718b5e8e4b18e9a4fab37f7eaa99e43386459376559080ac8f2856a.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-3cea6e0ad4715ed965c49bfb15dedfc632787b32ff6d8c3a474182b231146ab7.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/text_button-73590134e40cdb49f9abdc8e796cc00dc362693f3f0f6137d6cf9bb78c318ce7.css" /><link crossorigin="" href="https://fonts.gstatic.com/" rel="preconnect" /><link href="https://fonts.googleapis.com/css2?family=DM+Sans:ital,opsz,wght@0,9..40,100..1000;1,9..40,100..1000&family=Gupter:wght@400;500;700&family=IBM+Plex+Mono:wght@300;400&family=Material+Symbols+Outlined:opsz,wght,FILL,GRAD@20,400,0,0&display=swap" rel="stylesheet" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/common-10fa40af19d25203774df2d4a03b9b5771b45109c2304968038e88a81d1215c5.css" /> </head> <body> <div id='react-modal'></div> <div class="js-upgrade-ie-banner" style="display: none; text-align: center; padding: 8px 0; background-color: #ebe480;"><p style="color: #000; font-size: 12px; margin: 0 0 4px;">Academia.edu no longer supports Internet Explorer.</p><p style="color: #000; font-size: 12px; margin: 0;">To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to <a href="https://www.academia.edu/upgrade-browser">upgrade your browser</a>.</p></div><script>// Show this banner for all versions of IE if (!!window.MSInputMethodContext || /(MSIE)/.test(navigator.userAgent)) { document.querySelector('.js-upgrade-ie-banner').style.display = 'block'; }</script> <div class="bootstrap login"><div class="modal fade login-modal" id="login-modal"><div class="login-modal-dialog modal-dialog"><div class="modal-content"><div class="modal-header"><button class="close close" data-dismiss="modal" type="button"><span aria-hidden="true">×</span><span class="sr-only">Close</span></button><h4 class="modal-title text-center"><strong>Log In</strong></h4></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><button class="btn btn-fb btn-lg btn-block btn-v-center-content" id="login-facebook-oauth-button"><svg style="float: left; width: 19px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="facebook-square" class="svg-inline--fa fa-facebook-square fa-w-14" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M400 32H48A48 48 0 0 0 0 80v352a48 48 0 0 0 48 48h137.25V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.27c-30.81 0-40.42 19.12-40.42 38.73V256h68.78l-11 71.69h-57.78V480H400a48 48 0 0 0 48-48V80a48 48 0 0 0-48-48z"></path></svg><small><strong>Log in</strong> with <strong>Facebook</strong></small></button><br /><button class="btn btn-google btn-lg btn-block btn-v-center-content" id="login-google-oauth-button"><svg style="float: left; width: 22px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="google-plus" class="svg-inline--fa fa-google-plus fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M256,8C119.1,8,8,119.1,8,256S119.1,504,256,504,504,392.9,504,256,392.9,8,256,8ZM185.3,380a124,124,0,0,1,0-248c31.3,0,60.1,11,83,32.3l-33.6,32.6c-13.2-12.9-31.3-19.1-49.4-19.1-42.9,0-77.2,35.5-77.2,78.1S142.3,334,185.3,334c32.6,0,64.9-19.1,70.1-53.3H185.3V238.1H302.2a109.2,109.2,0,0,1,1.9,20.7c0,70.8-47.5,121.2-118.8,121.2ZM415.5,273.8v35.5H380V273.8H344.5V238.3H380V202.8h35.5v35.5h35.2v35.5Z"></path></svg><small><strong>Log in</strong> with <strong>Google</strong></small></button><br /><style type="text/css">.sign-in-with-apple-button { width: 100%; height: 52px; border-radius: 3px; border: 1px solid black; cursor: pointer; }</style><script src="https://appleid.cdn-apple.com/appleauth/static/jsapi/appleid/1/en_US/appleid.auth.js" type="text/javascript"></script><div class="sign-in-with-apple-button" data-border="false" data-color="white" id="appleid-signin"><span   ="Sign Up with Apple" class="u-fs11"></span></div><script>AppleID.auth.init({ clientId: 'edu.academia.applesignon', scope: 'name email', redirectURI: 'https://www.academia.edu/sessions', state: "fbb4fdc5ff426385a731d6d48f8862d322e9ab28c2ad92d9d509fd27c3e3f6bf", });</script><script>// Hacky way of checking if on fast loswp if (window.loswp == null) { (function() { const Google = window?.Aedu?.Auth?.OauthButton?.Login?.Google; const Facebook = window?.Aedu?.Auth?.OauthButton?.Login?.Facebook; if (Google) { new Google({ el: '#login-google-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } if (Facebook) { new Facebook({ el: '#login-facebook-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } })(); }</script></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><div class="hr-heading login-hr-heading"><span class="hr-heading-text">or</span></div></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><form class="js-login-form" action="https://www.academia.edu/sessions" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="LSWY74H3/VZRf2ssDcgbfsdod8dCj+aVPw8J6WMZojDE5FCYaEFLOw+YjAw5lZ7iZH9nYAWB3tMzhCthriyQmw==" autocomplete="off" /><div class="form-group"><label class="control-label" for="login-modal-email-input" style="font-size: 14px;">Email</label><input class="form-control" id="login-modal-email-input" name="login" type="email" /></div><div class="form-group"><label class="control-label" for="login-modal-password-input" style="font-size: 14px;">Password</label><input class="form-control" id="login-modal-password-input" name="password" type="password" /></div><input type="hidden" name="post_login_redirect_url" id="post_login_redirect_url" value="https://www.academia.edu/53418007/Glucagon_Like_Peptide_1_Stimulates_Lipolysis_in_Clonal_Pancreatic_Cells_HIT_" autocomplete="off" /><div class="checkbox"><label><input type="checkbox" name="remember_me" id="remember_me" value="1" checked="checked" /><small style="font-size: 12px; margin-top: 2px; display: inline-block;">Remember me on this computer</small></label></div><br><input type="submit" name="commit" value="Log In" class="btn btn-primary btn-block btn-lg js-login-submit" data-disable-with="Log In" /></br></form><script>typeof window?.Aedu?.recaptchaManagedForm === 'function' && window.Aedu.recaptchaManagedForm( document.querySelector('.js-login-form'), document.querySelector('.js-login-submit') );</script><small style="font-size: 12px;"><br />or <a data-target="#login-modal-reset-password-container" data-toggle="collapse" href="javascript:void(0)">reset password</a></small><div class="collapse" id="login-modal-reset-password-container"><br /><div class="well margin-0x"><form class="js-password-reset-form" action="https://www.academia.edu/reset_password" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="ITk1SFDhNQISKuQT3iYbaYOQ+gICMNN14CKfVEm+8YTI+P0/uVeDb0zNAzPqe571IIfqpUU+6zPsqb3chIvDLw==" autocomplete="off" /><p>Enter the email address you signed up with and we'll email you a reset link.</p><div class="form-group"><input class="form-control" name="email" type="email" /></div><input class="btn btn-primary btn-block g-recaptcha js-password-reset-submit" data-sitekey="6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj" type="submit" value="Email me a link" /></form></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/collapse-45805421cf446ca5adf7aaa1935b08a3a8d1d9a6cc5d91a62a2a3a00b20b3e6a.js"], function() { // from javascript_helper.rb $("#login-modal-reset-password-container").on("shown.bs.collapse", function() { $(this).find("input[type=email]").focus(); }); }); </script> </div></div></div><div class="modal-footer"><div class="text-center"><small style="font-size: 12px;">Need an account? <a rel="nofollow" href="https://www.academia.edu/signup">Click here to sign up</a></small></div></div></div></div></div></div><script>// If we are on subdomain or non-bootstrapped page, redirect to login page instead of showing modal (function(){ if (typeof $ === 'undefined') return; var host = window.location.hostname; if ((host === $domain || host === "www."+$domain) && (typeof $().modal === 'function')) { $("#nav_log_in").click(function(e) { // Don't follow the link and open the modal e.preventDefault(); $("#login-modal").on('shown.bs.modal', function() { $(this).find("#login-modal-email-input").focus() }).modal('show'); }); } })()</script> <div id="fb-root"></div><script>window.fbAsyncInit = function() { FB.init({ appId: "2369844204", version: "v8.0", status: true, cookie: true, xfbml: true }); // Additional initialization code. if (window.InitFacebook) { // facebook.ts already loaded, set it up. window.InitFacebook(); } else { // Set a flag for facebook.ts to find when it loads. window.academiaAuthReadyFacebook = true; } };</script> <div id="google-root"></div><script>window.loadGoogle = function() { if (window.InitGoogle) { // google.ts already loaded, set it up. window.InitGoogle("331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"); } else { // Set a flag for google.ts to use when it loads. window.GoogleClientID = "331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"; } };</script> <div class="header--container" id="main-header-container"><div class="header--inner-container header--inner-container-ds2"><div class="header-ds2--left-wrapper"><div class="header-ds2--left-wrapper-inner"><a data-main-header-link-target="logo_home" href="https://www.academia.edu/"><img class="hide-on-desktop-redesign" style="height: 24px; width: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015-A.svg" width="24" height="24" /><img width="145.2" height="18" class="hide-on-mobile-redesign" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015.svg" /></a><div class="header--search-container header--search-container-ds2"><form class="js-SiteSearch-form select2-no-default-pills" action="https://www.academia.edu/search" accept-charset="UTF-8" method="get"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><svg style="width: 14px; height: 14px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="search" class="header--search-icon svg-inline--fa fa-search fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M505 442.7L405.3 343c-4.5-4.5-10.6-7-17-7H372c27.6-35.3 44-79.7 44-128C416 93.1 322.9 0 208 0S0 93.1 0 208s93.1 208 208 208c48.3 0 92.7-16.4 128-44v16.3c0 6.4 2.5 12.5 7 17l99.7 99.7c9.4 9.4 24.6 9.4 33.9 0l28.3-28.3c9.4-9.4 9.4-24.6.1-34zM208 336c-70.7 0-128-57.2-128-128 0-70.7 57.2-128 128-128 70.7 0 128 57.2 128 128 0 70.7-57.2 128-128 128z"></path></svg><input class="header--search-input header--search-input-ds2 js-SiteSearch-form-input" data-main-header-click-target="search_input" name="q" placeholder="Search" type="text" /></form></div></div></div><nav class="header--nav-buttons header--nav-buttons-ds2 js-main-nav"><a class="ds2-5-button ds2-5-button--secondary js-header-login-url header-button-ds2 header-login-ds2 hide-on-mobile-redesign" href="https://www.academia.edu/login" rel="nofollow">Log In</a><a class="ds2-5-button ds2-5-button--secondary header-button-ds2 hide-on-mobile-redesign" href="https://www.academia.edu/signup" rel="nofollow">Sign Up</a><button class="header--hamburger-button header--hamburger-button-ds2 hide-on-desktop-redesign js-header-hamburger-button"><div class="icon-bar"></div><div class="icon-bar" style="margin-top: 4px;"></div><div class="icon-bar" style="margin-top: 4px;"></div></button></nav></div><ul class="header--dropdown-container js-header-dropdown"><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/login" rel="nofollow">Log In</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/signup" rel="nofollow">Sign Up</a></li><li class="header--dropdown-row js-header-dropdown-expand-button"><button class="header--dropdown-button">more<svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="caret-down" class="header--dropdown-button-icon svg-inline--fa fa-caret-down fa-w-10" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path fill="currentColor" d="M31.3 192h257.3c17.8 0 26.7 21.5 14.1 34.1L174.1 354.8c-7.8 7.8-20.5 7.8-28.3 0L17.2 226.1C4.6 213.5 13.5 192 31.3 192z"></path></svg></button></li><li><ul class="header--expanded-dropdown-container"><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/about">About</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/press">Press</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://medium.com/@academia">Blog</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/documents">Papers</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/terms">Terms</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/privacy">Privacy</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/copyright">Copyright</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/hiring"><svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="header--dropdown-row-icon svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg>We're Hiring!</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://support.academia.edu/"><svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="header--dropdown-row-icon svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg>Help Center</a></li><li class="header--dropdown-row js-header-dropdown-collapse-button"><button class="header--dropdown-button">less<svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="caret-up" class="header--dropdown-button-icon svg-inline--fa fa-caret-up fa-w-10" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path fill="currentColor" d="M288.662 352H31.338c-17.818 0-26.741-21.543-14.142-34.142l128.662-128.662c7.81-7.81 20.474-7.81 28.284 0l128.662 128.662c12.6 12.599 3.676 34.142-14.142 34.142z"></path></svg></button></li></ul></li></ul></div> <script src="//a.academia-assets.com/assets/webpack_bundles/fast_loswp-bundle-86832e264efa375cdd3fa5979579c95643bf6a5c1b20c95ec7a98005fcb4b9a4.js" defer="defer"></script><script>window.loswp = {}; window.loswp.author = 16608156; window.loswp.bulkDownloadFilterCounts = {}; window.loswp.hasDownloadableAttachment = true; window.loswp.hasViewableAttachments = true; // TODO: just use routes for this window.loswp.loginUrl = "https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F53418007%2FGlucagon_Like_Peptide_1_Stimulates_Lipolysis_in_Clonal_Pancreatic_Cells_HIT_%3Fauto%3Ddownload"; window.loswp.translateUrl = "https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F53418007%2FGlucagon_Like_Peptide_1_Stimulates_Lipolysis_in_Clonal_Pancreatic_Cells_HIT_%3Fshow_translation%3Dtrue"; window.loswp.previewableAttachments = [{"id":70271938,"identifier":"Attachment_70271938","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":53418007,"created_at":"2021-09-26T14:24:34.599-07:00","from_world_paper_id":174063158,"updated_at":"2021-09-26T14:47:40.819-07:00","_data":{"publication_date":"2001,,","publication_name":"Diabetes"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"en","title":"Glucagon-Like Peptide 1 Stimulates Lipolysis in Clonal Pancreatic �Cells (HIT)","broadcastable":false,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [16608156]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":70271938,"attachmentType":"pdf"}"><img alt="First page of “Glucagon-Like Peptide 1 Stimulates Lipolysis in Clonal Pancreatic �Cells (HIT)”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/70271938/mini_magick20210926-14757-gllki1.png?1632691584" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/assets/single_work_splash/adobe.icon-574afd46eb6b03a77a153a647fb47e30546f9215c0ee6a25df597a779717f9ef.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Glucagon-Like Peptide 1 Stimulates Lipolysis in Clonal Pancreatic �Cells (HIT)</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="16608156" href="https://upenn.academia.edu/BarbaraCorkey"><img alt="Profile image of Barbara Corkey" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Barbara Corkey</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">2001, Diabetes</p></div><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":70271938,"attachmentType":"pdf","workUrl":"https://www.academia.edu/53418007/Glucagon_Like_Peptide_1_Stimulates_Lipolysis_in_Clonal_Pancreatic_Cells_HIT_"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":70271938,"attachmentType":"pdf","workUrl":"https://www.academia.edu/53418007/Glucagon_Like_Peptide_1_Stimulates_Lipolysis_in_Clonal_Pancreatic_Cells_HIT_"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="70271938" data-landing_url="https://www.academia.edu/53418007/Glucagon_Like_Peptide_1_Stimulates_Lipolysis_in_Clonal_Pancreatic_Cells_HIT_" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="92810572" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/92810572/Glucagon_Like_Peptide_1_Stimulates_Lipolysis_in_Clonal_Pancreatic_%CE%B2_Cells_HIT_">Glucagon-Like Peptide 1 Stimulates Lipolysis in Clonal Pancreatic β-Cells (HIT)</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="38853996" href="https://independent.academia.edu/JamesHamilton24">James Hamilton</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Diabetes, 2001</p><p class="ds-related-work--abstract ds2-5-body-sm">Glucagon-like peptide 1 (GLP-1) is the most potent physiological incretin for insulin secretion from the pancreatic β-cell, but its mechanism of action has not been established. It interacts with specific cell-surface receptors, generates cAMP, and thereby activates protein kinase A (PKA). Many changes in pancreatic β-cell function have been attributed to PKA activation, but the contribution of each one to the secretory response is unknown. We show here for the first time that GLP-1 rapidly released free fatty acids (FFAs) from cellular stores, thereby lowering intracellular pH (pHi) and stimulating FFA oxidation in clonal β-cells (HIT). Similar changes were observed with forskolin, suggesting that stimulation of lipolysis was a function of PKA activation in β-cells. Triacsin C, which inhibits the conversion of FFAs to long-chain acyl CoA (LC-CoA), enhanced basal FFA efflux as well as GLP-1-induced acidification and efflux of FFAs from the cell. Increasing the concentration of the l...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Glucagon-Like Peptide 1 Stimulates Lipolysis in Clonal Pancreatic β-Cells (HIT)","attachmentId":95720625,"attachmentType":"pdf","work_url":"https://www.academia.edu/92810572/Glucagon_Like_Peptide_1_Stimulates_Lipolysis_in_Clonal_Pancreatic_%CE%B2_Cells_HIT_","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/92810572/Glucagon_Like_Peptide_1_Stimulates_Lipolysis_in_Clonal_Pancreatic_%CE%B2_Cells_HIT_"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="9115906" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/9115906/Glucagon_like_peptide_1_GLP_1_and_glucose_metabolism_in_human_myocytes">Glucagon-like peptide-1 (GLP-1) and glucose metabolism in human myocytes</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="20746334" href="https://independent.academia.edu/LuisM%C3%A1rquez1">Luis Márquez</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Endocrinology, 2002</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Glucagon-like peptide-1 (GLP-1) and glucose metabolism in human myocytes","attachmentId":35408262,"attachmentType":"pdf","work_url":"https://www.academia.edu/9115906/Glucagon_like_peptide_1_GLP_1_and_glucose_metabolism_in_human_myocytes","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/9115906/Glucagon_like_peptide_1_GLP_1_and_glucose_metabolism_in_human_myocytes"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="30192602" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/30192602/cAMP_secretion_coupling_is_impaired_in_diabetic_GK_Par_rat_cells_a_defect_counteracted_by_GLP_1">cAMP-secretion coupling is impaired in diabetic GK/Par rat -cells: a defect counteracted by GLP-1</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="57399477" href="https://independent.academia.edu/BernardPortha">Bernard Portha</a></div><p class="ds-related-work--metadata ds2-5-body-xs">AJP: Endocrinology and Metabolism, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"cAMP-secretion coupling is impaired in diabetic GK/Par rat -cells: a defect counteracted by GLP-1","attachmentId":50652201,"attachmentType":"pdf","work_url":"https://www.academia.edu/30192602/cAMP_secretion_coupling_is_impaired_in_diabetic_GK_Par_rat_cells_a_defect_counteracted_by_GLP_1","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/30192602/cAMP_secretion_coupling_is_impaired_in_diabetic_GK_Par_rat_cells_a_defect_counteracted_by_GLP_1"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="62847148" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/62847148/Glucagon_like_peptide_1_and_fatty_acids_amplify_pulsatile_insulin_secretion_from_perifused_rat_islets">Glucagon-like peptide 1 and fatty acids amplify pulsatile insulin secretion from perifused rat islets</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="16608156" href="https://upenn.academia.edu/BarbaraCorkey">Barbara Corkey</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biochemical Journal, 2003</p><p class="ds-related-work--abstract ds2-5-body-sm">Glucose-induced insulin secretion from isolated, perifused rat islets is pulsatile with a period of about 5—10min, similar to the insulin oscillations that are seen in healthy humans but which are impaired in Type II diabetes. We evaluated the pattern of enhancement by the potent incretin, glucagon-like peptide 1 (GLP-1). GLP-1 increased the amplitude of pulses and the magnitude of insulin secretion from the perifused islets, without affecting the average time interval between pulses. Forskolin and the phosphodiesterase inhibitor isobutylmethylxanthine had the same effect, suggesting that the effect was due to elevated cAMP levels. The possibility that cAMP might enhance the amplitude of pulses by reducing phosphofructo-2-kinase (PFK-2) activity was eliminated when the liver isoform of PFK-2 was shown to be absent from β-cells. The possibility that cAMP enhanced pulsatile secretion, at least in part, by stimulating lipolysis was supported by the observations that added oleate had a ...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Glucagon-like peptide 1 and fatty acids amplify pulsatile insulin secretion from perifused rat islets","attachmentId":75482911,"attachmentType":"pdf","work_url":"https://www.academia.edu/62847148/Glucagon_like_peptide_1_and_fatty_acids_amplify_pulsatile_insulin_secretion_from_perifused_rat_islets","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/62847148/Glucagon_like_peptide_1_and_fatty_acids_amplify_pulsatile_insulin_secretion_from_perifused_rat_islets"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="31052271" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/31052271/Fatty_Acid_Signaling_in_the_Cell_and_Insulin_Secretion">Fatty Acid Signaling in the -Cell and Insulin Secretion</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="59197141" href="https://independent.academia.edu/MPeyot">M. Peyot</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Diabetes, 2006</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Fatty Acid Signaling in the -Cell and Insulin Secretion","attachmentId":51485813,"attachmentType":"pdf","work_url":"https://www.academia.edu/31052271/Fatty_Acid_Signaling_in_the_Cell_and_Insulin_Secretion","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/31052271/Fatty_Acid_Signaling_in_the_Cell_and_Insulin_Secretion"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="81752576" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/81752576/cAMP_secretion_coupling_is_impaired_in_diabetic_GK_Par_rat_%CE%B2_cells_a_defect_counteracted_by_GLP_1">cAMP-secretion coupling is impaired in diabetic GK/Par rat β-cells: a defect counteracted by GLP-1</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="28423296" href="https://independent.academia.edu/MichelineKergoat">Micheline Kergoat</a></div><p class="ds-related-work--metadata ds2-5-body-xs">American Journal of Physiology-Endocrinology and Metabolism, 2011</p><p class="ds-related-work--abstract ds2-5-body-sm">cAMP-raising agents with glucagon-like peptide-1 (GLP-1) as the first in class, exhibit multiple actions that are beneficial for the treatment of type 2 diabetic (T2D) patients, including improvement of glucose-induced insulin secretion (GIIS). To gain additional insight into the role of cAMP in the disturbed stimulus-secretion coupling within the diabetic β-cell, we examined more thoroughly the relationship between changes in islet cAMP concentration and insulin release in the GK/Par rat model of T2D. Basal cAMP content in GK/Par islets was significantly higher, whereas their basal insulin release was not significantly different from that of Wistar (W) islets. Even in the presence of IBMX or GLP-1, their insulin release did not significantly change despite further enhanced cAMP accumulation in both cases. The high basal cAMP level most likely reflects an increased cAMP generation in GK/Par compared with W islets since 1) forskolin dose-dependently induced an exaggerated cAMP accumu...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"cAMP-secretion coupling is impaired in diabetic GK/Par rat β-cells: a defect counteracted by GLP-1","attachmentId":87688095,"attachmentType":"pdf","work_url":"https://www.academia.edu/81752576/cAMP_secretion_coupling_is_impaired_in_diabetic_GK_Par_rat_%CE%B2_cells_a_defect_counteracted_by_GLP_1","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/81752576/cAMP_secretion_coupling_is_impaired_in_diabetic_GK_Par_rat_%CE%B2_cells_a_defect_counteracted_by_GLP_1"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="31052273" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/31052273/Hormone_Sensitive_Lipase_Has_a_Role_in_Lipid_Signaling_for_Insulin_Secretion_but_Is_Nonessential_for_the_Incretin_Action_of_Glucagon_Like_Peptide_1">Hormone-Sensitive Lipase Has a Role in Lipid Signaling for Insulin Secretion but Is Nonessential for the Incretin Action of Glucagon-Like Peptide 1</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="59197141" href="https://independent.academia.edu/MPeyot">M. Peyot</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Diabetes, 2004</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Hormone-Sensitive Lipase Has a Role in Lipid Signaling for Insulin Secretion but Is Nonessential for the Incretin Action of Glucagon-Like Peptide 1","attachmentId":51485812,"attachmentType":"pdf","work_url":"https://www.academia.edu/31052273/Hormone_Sensitive_Lipase_Has_a_Role_in_Lipid_Signaling_for_Insulin_Secretion_but_Is_Nonessential_for_the_Incretin_Action_of_Glucagon_Like_Peptide_1","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/31052273/Hormone_Sensitive_Lipase_Has_a_Role_in_Lipid_Signaling_for_Insulin_Secretion_but_Is_Nonessential_for_the_Incretin_Action_of_Glucagon_Like_Peptide_1"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="79002202" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/79002202/A_fatty_acid_dependent_step_is_critically_important_for_both_glucose_and_non_glucose_stimulated_insulin_secretion">A fatty acid- dependent step is critically important for both glucose- and non-glucose-stimulated insulin secretion</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="52362486" href="https://independent.academia.edu/JohnMcGarry4">John McGarry</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Clinical Investigation, 1998</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"A fatty acid- dependent step is critically important for both glucose- and non-glucose-stimulated insulin secretion","attachmentId":85868853,"attachmentType":"pdf","work_url":"https://www.academia.edu/79002202/A_fatty_acid_dependent_step_is_critically_important_for_both_glucose_and_non_glucose_stimulated_insulin_secretion","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/79002202/A_fatty_acid_dependent_step_is_critically_important_for_both_glucose_and_non_glucose_stimulated_insulin_secretion"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="13814210" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13814210/Multisite_regulation_of_insulin_secretion_by_cAMP_increasing_agonists_evidence_that_glucagon_like_peptide_1_and_glucagon_act_via_distinct_receptors">Multisite regulation of insulin secretion by cAMP-increasing agonists: evidence that glucagon-like peptide 1 and glucagon act via distinct receptors</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32912587" href="https://lu.academia.edu/ErikRenstr%C3%B6m">Erik Renström</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Pflugers Archiv-european Journal of Physiology, 1997</p><p class="ds-related-work--abstract ds2-5-body-sm">The mechanisms by which glucagon-like peptide 1(7–36)amide (GLP-1[7–36]amide) potentiates insulin secretion were investigated by measurements of whole-cell K+ and Ca2+ currents, membrane potential, the cytoplasmic Ca2+ concentration ([Ca2+]i) and exocytosis in mouse pancreatic B-cells. GLP-1(7–36)amide (10 nM) stimulated glucose-induced (10 mM) electrical activity in intact pancreatic islets. The effect was manifested as a 34% increase in the duration of the</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Multisite regulation of insulin secretion by cAMP-increasing agonists: evidence that glucagon-like peptide 1 and glucagon act via distinct receptors","attachmentId":44919960,"attachmentType":"pdf","work_url":"https://www.academia.edu/13814210/Multisite_regulation_of_insulin_secretion_by_cAMP_increasing_agonists_evidence_that_glucagon_like_peptide_1_and_glucagon_act_via_distinct_receptors","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/13814210/Multisite_regulation_of_insulin_secretion_by_cAMP_increasing_agonists_evidence_that_glucagon_like_peptide_1_and_glucagon_act_via_distinct_receptors"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="20383818" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/20383818/Glucose_and_GLP_1_Stimulate_cAMP_Production_via_Distinct_Adenylyl_Cyclases_in_INS_1E_Insulinoma_Cells">Glucose and GLP-1 Stimulate cAMP Production via Distinct Adenylyl Cyclases in INS-1E Insulinoma Cells</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="41743910" href="https://independent.academia.edu/LonnyLevin">Lonny Levin</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Journal of General Physiology, 2008</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Glucose and GLP-1 Stimulate cAMP Production via Distinct Adenylyl Cyclases in INS-1E Insulinoma Cells","attachmentId":41335601,"attachmentType":"pdf","work_url":"https://www.academia.edu/20383818/Glucose_and_GLP_1_Stimulate_cAMP_Production_via_Distinct_Adenylyl_Cyclases_in_INS_1E_Insulinoma_Cells","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/20383818/Glucose_and_GLP_1_Stimulate_cAMP_Production_via_Distinct_Adenylyl_Cyclases_in_INS_1E_Insulinoma_Cells"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":70271938,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":70271938,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_70271938" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="108404783" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/108404783/Insulin_inhibition_of_lipolysis_of_human_adipocytes_the_role_of_cyclic_adenosine_monophosphate">Insulin inhibition of lipolysis of human adipocytes: the role of cyclic adenosine monophosphate</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="47152832" href="https://independent.academia.edu/BoydTerry1">Boyd Terry</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Diabetes, 1979</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Insulin inhibition of lipolysis of human adipocytes: the role of cyclic adenosine monophosphate","attachmentId":106797943,"attachmentType":"pdf","work_url":"https://www.academia.edu/108404783/Insulin_inhibition_of_lipolysis_of_human_adipocytes_the_role_of_cyclic_adenosine_monophosphate","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/108404783/Insulin_inhibition_of_lipolysis_of_human_adipocytes_the_role_of_cyclic_adenosine_monophosphate"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="1" data-entity-id="58373509" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/58373509/Role_of_Fat_Hydrolysis_in_Regulating_Glucagon_Like_Peptide_1_Secretion">Role of Fat Hydrolysis in Regulating Glucagon-Like Peptide-1 Secretion</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="39396122" href="https://independent.academia.edu/JuergenDrewe">Juergen Drewe</a></div><p class="ds-related-work--metadata ds2-5-body-xs">The Journal of Clinical Endocrinology & Metabolism, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Role of Fat Hydrolysis in Regulating Glucagon-Like Peptide-1 Secretion","attachmentId":72816294,"attachmentType":"pdf","work_url":"https://www.academia.edu/58373509/Role_of_Fat_Hydrolysis_in_Regulating_Glucagon_Like_Peptide_1_Secretion","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/58373509/Role_of_Fat_Hydrolysis_in_Regulating_Glucagon_Like_Peptide_1_Secretion"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="2" data-entity-id="112420994" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/112420994/Inhibition_of_Monoacylglycerol_Lipase_Activity_Decreases_Glucose_Stimulated_Insulin_Secretion_in_INS_1_832_13_Cells_and_Rat_Islets">Inhibition of Monoacylglycerol Lipase Activity Decreases Glucose-Stimulated Insulin Secretion in INS-1 (832/13) Cells and Rat Islets</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="16608156" href="https://upenn.academia.edu/BarbaraCorkey">Barbara Corkey</a></div><p class="ds-related-work--metadata ds2-5-body-xs">PLOS ONE, 2016</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Inhibition of Monoacylglycerol Lipase Activity Decreases Glucose-Stimulated Insulin Secretion in INS-1 (832/13) Cells and Rat Islets","attachmentId":109657142,"attachmentType":"pdf","work_url":"https://www.academia.edu/112420994/Inhibition_of_Monoacylglycerol_Lipase_Activity_Decreases_Glucose_Stimulated_Insulin_Secretion_in_INS_1_832_13_Cells_and_Rat_Islets","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/112420994/Inhibition_of_Monoacylglycerol_Lipase_Activity_Decreases_Glucose_Stimulated_Insulin_Secretion_in_INS_1_832_13_Cells_and_Rat_Islets"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="3" data-entity-id="30157227" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/30157227/Glucagon_like_peptide_1_7_36_amide_confers_glucose_sensitivity_to_previously_glucose_incompetent_beta_cells_in_diabetic_rats_in_vivo_and_in_vitro_studies">Glucagon-like peptide-1(7-36)-amide confers glucose sensitivity to previously glucose-incompetent beta-cells in diabetic rats: in vivo and in vitro studies</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="57399477" href="https://independent.academia.edu/BernardPortha">Bernard Portha</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Endocrinology, 1997</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Glucagon-like peptide-1(7-36)-amide confers glucose sensitivity to previously glucose-incompetent beta-cells in diabetic rats: in vivo and in vitro studies","attachmentId":50614185,"attachmentType":"pdf","work_url":"https://www.academia.edu/30157227/Glucagon_like_peptide_1_7_36_amide_confers_glucose_sensitivity_to_previously_glucose_incompetent_beta_cells_in_diabetic_rats_in_vivo_and_in_vitro_studies","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/30157227/Glucagon_like_peptide_1_7_36_amide_confers_glucose_sensitivity_to_previously_glucose_incompetent_beta_cells_in_diabetic_rats_in_vivo_and_in_vitro_studies"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="4" data-entity-id="21612197" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/21612197/Glucagon_Like_Peptide_1_Regulation_of_Insulin_Secretion_and_Therapeutic_Potential">Glucagon-Like Peptide-1: Regulation of Insulin Secretion and Therapeutic Potential</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33371184" href="https://independent.academia.edu/BirgitteBrock">Birgitte Brock</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Basic <html_ent glyph="@amp;" ascii="&amp;"/> Clinical Pharmacology <html_ent glyph="@amp;" ascii="&amp;"/> Toxicology, 2004</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Glucagon-Like Peptide-1: Regulation of Insulin Secretion and Therapeutic Potential","attachmentId":42191940,"attachmentType":"pdf","work_url":"https://www.academia.edu/21612197/Glucagon_Like_Peptide_1_Regulation_of_Insulin_Secretion_and_Therapeutic_Potential","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/21612197/Glucagon_Like_Peptide_1_Regulation_of_Insulin_Secretion_and_Therapeutic_Potential"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="5" data-entity-id="14655107" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/14655107/Altered_cAMP_and_Ca2_signaling_in_mouse_pancreatic_islets_with_glucagon_like_peptide_1_receptor_null_phenotype">Altered cAMP and Ca2+ signaling in mouse pancreatic islets with glucagon-like peptide-1 receptor null phenotype</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33604043" href="https://uclouvain.academia.edu/PatrickGilon">Patrick Gilon</a><span>, </span><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33753065" href="https://kuleuven.academia.edu/FSchuit">F. Schuit</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Diabetes, 1999</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Altered cAMP and Ca2+ signaling in mouse pancreatic islets with glucagon-like peptide-1 receptor null phenotype","attachmentId":44004909,"attachmentType":"pdf","work_url":"https://www.academia.edu/14655107/Altered_cAMP_and_Ca2_signaling_in_mouse_pancreatic_islets_with_glucagon_like_peptide_1_receptor_null_phenotype","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/14655107/Altered_cAMP_and_Ca2_signaling_in_mouse_pancreatic_islets_with_glucagon_like_peptide_1_receptor_null_phenotype"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="6" data-entity-id="93268683" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/93268683/Molecular_or_Pharmacologic_Perturbation_of_the_Link_between_Glucose_and_Lipid_Metabolism_Is_without_Effect_on_Glucose_stimulated_Insulin_Secretion">Molecular or Pharmacologic Perturbation of the Link between Glucose and Lipid Metabolism Is without Effect on Glucose-stimulated Insulin Secretion</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="127031582" href="https://independent.academia.edu/LauraSegall">Laura Segall</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Biological Chemistry, 1998</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Molecular or Pharmacologic Perturbation of the Link between Glucose and Lipid Metabolism Is without Effect on Glucose-stimulated Insulin Secretion","attachmentId":96052701,"attachmentType":"pdf","work_url":"https://www.academia.edu/93268683/Molecular_or_Pharmacologic_Perturbation_of_the_Link_between_Glucose_and_Lipid_Metabolism_Is_without_Effect_on_Glucose_stimulated_Insulin_Secretion","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/93268683/Molecular_or_Pharmacologic_Perturbation_of_the_Link_between_Glucose_and_Lipid_Metabolism_Is_without_Effect_on_Glucose_stimulated_Insulin_Secretion"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="7" data-entity-id="104130662" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/104130662/Dynamics_of_plasma_active_GLP_1_versus_insulin_and_glucose_concentrations_during_GLP_1_infusion_in_rat_model_of_postprandial_hyperglycemia">Dynamics of plasma active GLP-1 versus insulin and glucose concentrations during GLP-1 infusion in rat model of postprandial hyperglycemia</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32731360" href="https://independent.academia.edu/ToshihikoYada">Toshihiko Yada</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Endocrine Journal, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Dynamics of plasma active GLP-1 versus insulin and glucose concentrations during GLP-1 infusion in rat model of postprandial hyperglycemia","attachmentId":103939055,"attachmentType":"pdf","work_url":"https://www.academia.edu/104130662/Dynamics_of_plasma_active_GLP_1_versus_insulin_and_glucose_concentrations_during_GLP_1_infusion_in_rat_model_of_postprandial_hyperglycemia","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/104130662/Dynamics_of_plasma_active_GLP_1_versus_insulin_and_glucose_concentrations_during_GLP_1_infusion_in_rat_model_of_postprandial_hyperglycemia"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="8" data-entity-id="21945287" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/21945287/Effect_of_GLP_1_on_glucose_transport_and_its_cell_signalling_in_human_myocytes">Effect of GLP-1 on glucose transport and its cell signalling in human myocytes</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="43191161" href="https://independent.academia.edu/ValverdeIsabel">Isabel Valverde</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Regulatory Peptides, 2005</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Effect of GLP-1 on glucose transport and its cell signalling in human myocytes","attachmentId":42669113,"attachmentType":"pdf","work_url":"https://www.academia.edu/21945287/Effect_of_GLP_1_on_glucose_transport_and_its_cell_signalling_in_human_myocytes","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/21945287/Effect_of_GLP_1_on_glucose_transport_and_its_cell_signalling_in_human_myocytes"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="9" data-entity-id="13814169" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/13814169/GLP_1_Inhibits_and_Adrenaline_Stimulates_Glucagon_Release_by_Differential_Modulation_of_N_and_L_Type_Ca2_Channel_Dependent_Exocytosis">GLP-1 Inhibits and Adrenaline Stimulates Glucagon Release by Differential Modulation of N- and L-Type Ca2+ Channel-Dependent Exocytosis</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32979790" href="https://independent.academia.edu/FernandoAbdulkader">Fernando Abdulkader</a><span>, </span><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32912587" href="https://lu.academia.edu/ErikRenstr%C3%B6m">Erik Renström</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Cell Metabolism, 2010</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"GLP-1 Inhibits and Adrenaline Stimulates Glucagon Release by Differential Modulation of N- and L-Type Ca2+ Channel-Dependent Exocytosis","attachmentId":44920594,"attachmentType":"pdf","work_url":"https://www.academia.edu/13814169/GLP_1_Inhibits_and_Adrenaline_Stimulates_Glucagon_Release_by_Differential_Modulation_of_N_and_L_Type_Ca2_Channel_Dependent_Exocytosis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/13814169/GLP_1_Inhibits_and_Adrenaline_Stimulates_Glucagon_Release_by_Differential_Modulation_of_N_and_L_Type_Ca2_Channel_Dependent_Exocytosis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="10" data-entity-id="117947885" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/117947885/Effects_of_glucagon_and_insulin_on_cytoplasmic_protein_phosphorylation_in_hepatocytes">Effects of glucagon and insulin on cytoplasmic protein phosphorylation in hepatocytes</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37661999" href="https://independent.academia.edu/JosephAvruch">Joseph Avruch</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Biological Chemistry, 1978</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Effects of glucagon and insulin on cytoplasmic protein phosphorylation in hepatocytes","attachmentId":113686240,"attachmentType":"pdf","work_url":"https://www.academia.edu/117947885/Effects_of_glucagon_and_insulin_on_cytoplasmic_protein_phosphorylation_in_hepatocytes","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/117947885/Effects_of_glucagon_and_insulin_on_cytoplasmic_protein_phosphorylation_in_hepatocytes"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="11" data-entity-id="62322052" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/62322052/Molecular_mechanisms_of_lipoapoptosis_and_metformin_protection_in_GLP_1_secreting_cells">Molecular mechanisms of lipoapoptosis and metformin protection in GLP-1 secreting cells</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32730894" href="https://independent.academia.edu/StigHolm">Jens J U U L Holst</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biochemical and Biophysical Research Communications, 2012</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Molecular mechanisms of lipoapoptosis and metformin protection in GLP-1 secreting cells","attachmentId":75128008,"attachmentType":"pdf","work_url":"https://www.academia.edu/62322052/Molecular_mechanisms_of_lipoapoptosis_and_metformin_protection_in_GLP_1_secreting_cells","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/62322052/Molecular_mechanisms_of_lipoapoptosis_and_metformin_protection_in_GLP_1_secreting_cells"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="12" data-entity-id="109604251" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/109604251/Glucagon_Like_Peptide_I_Increases_Cytoplasmic_Calcium_in_Insulin_Secreting_%CE%B2TC3_Cells_by_Enhancement_of_Intracellular_Calcium_Mobilization">Glucagon-Like Peptide I Increases Cytoplasmic Calcium in Insulin-Secreting βTC3-Cells by Enhancement of Intracellular Calcium Mobilization</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="42111793" href="https://independent.academia.edu/SteenDissing">Steen Dissing</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Diabetes, 1995</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Glucagon-Like Peptide I Increases Cytoplasmic Calcium in Insulin-Secreting βTC3-Cells by Enhancement of Intracellular Calcium Mobilization","attachmentId":107679130,"attachmentType":"pdf","work_url":"https://www.academia.edu/109604251/Glucagon_Like_Peptide_I_Increases_Cytoplasmic_Calcium_in_Insulin_Secreting_%CE%B2TC3_Cells_by_Enhancement_of_Intracellular_Calcium_Mobilization","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/109604251/Glucagon_Like_Peptide_I_Increases_Cytoplasmic_Calcium_in_Insulin_Secreting_%CE%B2TC3_Cells_by_Enhancement_of_Intracellular_Calcium_Mobilization"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="13" data-entity-id="62322070" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/62322070/The_Physiology_of_Glucagon_like_Peptide_1_Physiological">The Physiology of Glucagon-like Peptide 1 | Physiological</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32730894" href="https://independent.academia.edu/StigHolm">Jens J U U L Holst</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Physiological reviews, 2007</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"The Physiology of Glucagon-like Peptide 1 | Physiological","attachmentId":75128026,"attachmentType":"pdf","work_url":"https://www.academia.edu/62322070/The_Physiology_of_Glucagon_like_Peptide_1_Physiological","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/62322070/The_Physiology_of_Glucagon_like_Peptide_1_Physiological"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="14" data-entity-id="15485366" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/15485366/Interaction_between_specific_fatty_acids_GLP_1_and_insulin_secretion_in_humans">Interaction between specific fatty acids, GLP-1 and insulin secretion in humans</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34628279" href="https://independent.academia.edu/CarineBeysen">Carine Beysen</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Diabetologia, 2002</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Interaction between specific fatty acids, GLP-1 and insulin secretion in humans","attachmentId":43151424,"attachmentType":"pdf","work_url":"https://www.academia.edu/15485366/Interaction_between_specific_fatty_acids_GLP_1_and_insulin_secretion_in_humans","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/15485366/Interaction_between_specific_fatty_acids_GLP_1_and_insulin_secretion_in_humans"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="15" data-entity-id="100807094" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/100807094/Discriminative_insulin_antagonism_of_stimulatory_effects_of_various_cAMP_analogs_on_adipocyte_lipolysis_and_hepatocyte_glycogenolysis">Discriminative insulin antagonism of stimulatory effects of various cAMP analogs on adipocyte lipolysis and hepatocyte glycogenolysis</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="210782460" href="https://independent.academia.edu/STEPHENBEEBE2">STEPHEN BEEBE</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Biological Chemistry, 1985</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Discriminative insulin antagonism of stimulatory effects of various cAMP analogs on adipocyte lipolysis and hepatocyte glycogenolysis","attachmentId":101523748,"attachmentType":"pdf","work_url":"https://www.academia.edu/100807094/Discriminative_insulin_antagonism_of_stimulatory_effects_of_various_cAMP_analogs_on_adipocyte_lipolysis_and_hepatocyte_glycogenolysis","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/100807094/Discriminative_insulin_antagonism_of_stimulatory_effects_of_various_cAMP_analogs_on_adipocyte_lipolysis_and_hepatocyte_glycogenolysis"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="16" data-entity-id="14115431" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/14115431/Evidence_for_the_key_role_of_the_adipocyte_cGMP_inhibited_cAMP_phosphodiesterase_in_the_antilipolytic_action_of_insulin">Evidence for the key role of the adipocyte cGMP-inhibited cAMP phosphodiesterase in the antilipolytic action of insulin</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="33116053" href="https://lu.academia.edu/MartinRidderstr%C3%A5le">Martin Ridderstråle</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1995</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Evidence for the key role of the adipocyte cGMP-inhibited cAMP phosphodiesterase in the antilipolytic action of insulin","attachmentId":44588833,"attachmentType":"pdf","work_url":"https://www.academia.edu/14115431/Evidence_for_the_key_role_of_the_adipocyte_cGMP_inhibited_cAMP_phosphodiesterase_in_the_antilipolytic_action_of_insulin","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/14115431/Evidence_for_the_key_role_of_the_adipocyte_cGMP_inhibited_cAMP_phosphodiesterase_in_the_antilipolytic_action_of_insulin"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="17" data-entity-id="24777943" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/24777943/Metabolic_antagonism_between_insulin_action_and_activators_of_adenylate_cyclase_in_rat_fat_cells">Metabolic antagonism between insulin action and activators of adenylate cyclase in rat fat cells</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="38434233" href="https://independent.academia.edu/Joaqu%C3%ADnJim%C3%A9nez">Joaquín Jiménez</a></div><p class="ds-related-work--metadata ds2-5-body-xs">International Journal of Biochemistry, 1987</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Metabolic antagonism between insulin action and activators of adenylate cyclase in rat fat cells","attachmentId":45105804,"attachmentType":"pdf","work_url":"https://www.academia.edu/24777943/Metabolic_antagonism_between_insulin_action_and_activators_of_adenylate_cyclase_in_rat_fat_cells","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/24777943/Metabolic_antagonism_between_insulin_action_and_activators_of_adenylate_cyclase_in_rat_fat_cells"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="18" data-entity-id="4464973" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/4464973/Direct_and_indirect_actions_of_nutrients_in_the_regulation_of_insulin_secretion_from_the_pancreatic_%CE%B2_cells">Direct and indirect actions of nutrients in the regulation of insulin secretion from the pancreatic β cells</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="5513093" href="https://independent.academia.edu/OmarShibier">Omar Shibier</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Proceedings of The Nutrition Society, 1991</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Direct and indirect actions of nutrients in the regulation of insulin secretion from the pancreatic β cells","attachmentId":49847596,"attachmentType":"pdf","work_url":"https://www.academia.edu/4464973/Direct_and_indirect_actions_of_nutrients_in_the_regulation_of_insulin_secretion_from_the_pancreatic_%CE%B2_cells","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/4464973/Direct_and_indirect_actions_of_nutrients_in_the_regulation_of_insulin_secretion_from_the_pancreatic_%CE%B2_cells"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="19" data-entity-id="116132115" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/116132115/GLP_1_induced_alterations_in_the_glucose_stimulated_insulin_secretory_dose_response_curve">GLP-1-induced alterations in the glucose-stimulated insulin secretory dose-response curve</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="57633851" href="https://independent.academia.edu/BurkhardG%C3%B6ke">Burkhard Göke</a></div><p class="ds-related-work--metadata ds2-5-body-xs">American Journal of Physiology-Endocrinology and Metabolism, 2001</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"GLP-1-induced alterations in the glucose-stimulated insulin secretory dose-response curve","attachmentId":112346763,"attachmentType":"pdf","work_url":"https://www.academia.edu/116132115/GLP_1_induced_alterations_in_the_glucose_stimulated_insulin_secretory_dose_response_curve","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/116132115/GLP_1_induced_alterations_in_the_glucose_stimulated_insulin_secretory_dose_response_curve"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="20" data-entity-id="72757533" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/72757533/Preserved_inhibitory_potency_of_GLP_1_on_glucagon_secretion_in_type_2_diabetes_mellitus">Preserved inhibitory potency of GLP-1 on glucagon secretion in type 2 diabetes mellitus</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="32730894" href="https://independent.academia.edu/StigHolm">Jens J U U L Holst</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Journal of Clinical …, 2009</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Preserved inhibitory potency of GLP-1 on glucagon secretion in type 2 diabetes mellitus","attachmentId":81558618,"attachmentType":"pdf","work_url":"https://www.academia.edu/72757533/Preserved_inhibitory_potency_of_GLP_1_on_glucagon_secretion_in_type_2_diabetes_mellitus","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/72757533/Preserved_inhibitory_potency_of_GLP_1_on_glucagon_secretion_in_type_2_diabetes_mellitus"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related topics</h2><div class="ds-research-interests--pills-container"><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="4581" href="https://www.academia.edu/Documents/in/Diabetes">Diabetes</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="9534" href="https://www.academia.edu/Documents/in/Calcium">Calcium</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="12981" href="https://www.academia.edu/Documents/in/Enzyme_Inhibitors">Enzyme Inhibitors</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="57808" href="https://www.academia.edu/Documents/in/Cell_line">Cell line</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="59370" href="https://www.academia.edu/Documents/in/In_Vitro">In Vitro</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="71402" href="https://www.academia.edu/Documents/in/Glucagon">Glucagon</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="71426" href="https://www.academia.edu/Documents/in/Insulin_Secretion">Insulin Secretion</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="100332" href="https://www.academia.edu/Documents/in/Lipolysis">Lipolysis</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="541937" href="https://www.academia.edu/Documents/in/Stimulation">Stimulation</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="725615" href="https://www.academia.edu/Documents/in/Mechanism_of_action">Mechanism of action</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="818710" href="https://www.academia.edu/Documents/in/Free_Fatty_Acid">Free Fatty Acid</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="1078292" href="https://www.academia.edu/Documents/in/Cell_Surface_Markers">Cell Surface Markers</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="1137254" href="https://www.academia.edu/Documents/in/Hydrogen-Ion_Concentration">Hydrogen-Ion Concentration</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="1209754" href="https://www.academia.edu/Documents/in/Lipase">Lipase</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="1270314" href="https://www.academia.edu/Documents/in/Lactones">Lactones</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="1705044" href="https://www.academia.edu/Documents/in/islets_of_Langerhans">islets of Langerhans</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="3763225" href="https://www.academia.edu/Documents/in/Medical_and_Health_Sciences">Medical and Health Sciences</a></div></div></div></div></div><div class="footer--content"><ul class="footer--main-links hide-on-mobile"><li><a href="https://www.academia.edu/about">About</a></li><li><a href="https://www.academia.edu/press">Press</a></li><li><a rel="nofollow" href="https://medium.com/academia">Blog</a></li><li><a href="https://www.academia.edu/documents">Papers</a></li><li><a href="https://www.academia.edu/topics">Topics</a></li><li><a href="https://www.academia.edu/hiring"><svg style="width: 13px; height: 13px; position: relative; bottom: -1px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg> <strong>We're Hiring!</strong></a></li><li><a href="https://support.academia.edu/"><svg style="width: 12px; height: 12px; position: relative; bottom: -1px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg> <strong>Help Center</strong></a></li></ul><ul class="footer--research-interests"><li>Find new research papers in:</li><li><a href="https://www.academia.edu/Documents/in/Physics">Physics</a></li><li><a href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a></li><li><a href="https://www.academia.edu/Documents/in/Biology">Biology</a></li><li><a href="https://www.academia.edu/Documents/in/Health_Sciences">Health Sciences</a></li><li><a href="https://www.academia.edu/Documents/in/Ecology">Ecology</a></li><li><a href="https://www.academia.edu/Documents/in/Earth_Sciences">Earth Sciences</a></li><li><a href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a></li><li><a href="https://www.academia.edu/Documents/in/Mathematics">Mathematics</a></li><li><a href="https://www.academia.edu/Documents/in/Computer_Science">Computer Science</a></li></ul><ul class="footer--legal-links hide-on-mobile"><li><a href="https://www.academia.edu/terms">Terms</a></li><li><a href="https://www.academia.edu/privacy">Privacy</a></li><li><a href="https://www.academia.edu/copyright">Copyright</a></li><li>Academia ©2024</li></ul></div> </body> </html>