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class="vector-toc-link" href="#Exprimarea_matematică"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Exprimarea matematică</span> </div> </a> <ul id="toc-Exprimarea_matematică-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Tipuri_de_clearance" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Tipuri_de_clearance"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Tipuri de clearance</span> </div> </a> <button aria-controls="toc-Tipuri_de_clearance-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Tipuri de clearance subsection</span> </button> <ul id="toc-Tipuri_de_clearance-sublist" class="vector-toc-list"> <li id="toc-Clearance-ul_sistemic_total_ClT" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Clearance-ul_sistemic_total_ClT"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.1</span> <span>Clearance-ul sistemic total Cl<sub>T</sub></span> </div> </a> <ul id="toc-Clearance-ul_sistemic_total_ClT-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Clearance-ul_plasmatic_Clp" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Clearance-ul_plasmatic_Clp"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.2</span> <span>Clearance-ul plasmatic Cl<sub>p</sub></span> </div> </a> <ul id="toc-Clearance-ul_plasmatic_Clp-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Clearance-ul_unui_organ_de_epurare_Clorg" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Clearance-ul_unui_organ_de_epurare_Clorg"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.3</span> <span>Clearance-ul unui organ de epurare Cl<sub>org</sub></span> </div> </a> <ul id="toc-Clearance-ul_unui_organ_de_epurare_Clorg-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Clearance-ul_intrinsec" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Clearance-ul_intrinsec"> <div class="vector-toc-text"> <span class="vector-toc-numb">2.4</span> <span>Clearance-ul intrinsec</span> </div> </a> <ul id="toc-Clearance-ul_intrinsec-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Bibliografie" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Bibliografie"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Bibliografie</span> </div> </a> <ul id="toc-Bibliografie-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Referințe" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Referințe"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Referințe</span> </div> </a> <ul id="toc-Referințe-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Cuprins" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Comută cuprinsul" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Comută cuprinsul</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Clearance plasmatic</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Mergeți la un articol în altă limbă. Disponibil în 22 limbi" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-22" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">22 limbi</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%AA%D8%B5%D9%81%D9%8A%D8%A9_(%D8%B7%D8%A8)" title="تصفية (طب) – arabă" lang="ar" hreflang="ar" data-title="تصفية (طب)" data-language-autonym="العربية" data-language-local-name="arabă" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Klirens_(farmakologija)" title="Klirens (farmakologija) – bosniacă" lang="bs" hreflang="bs" data-title="Klirens (farmakologija)" data-language-autonym="Bosanski" data-language-local-name="bosniacă" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-cs mw-list-item"><a href="https://cs.wikipedia.org/wiki/Clearance" title="Clearance – cehă" lang="cs" hreflang="cs" data-title="Clearance" data-language-autonym="Čeština" data-language-local-name="cehă" class="interlanguage-link-target"><span>Čeština</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Clearance_(pharmacology)" title="Clearance (pharmacology) – engleză" lang="en" hreflang="en" data-title="Clearance (pharmacology)" data-language-autonym="English" data-language-local-name="engleză" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Depuraci%C3%B3n_(medicina)" title="Depuración (medicina) – spaniolă" lang="es" hreflang="es" data-title="Depuración (medicina)" data-language-autonym="Español" data-language-local-name="spaniolă" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%DA%A9%D9%84%DB%8C%D8%B1%D8%A7%D9%86%D8%B3" title="کلیرانس – persană" lang="fa" hreflang="fa" data-title="کلیرانس" data-language-autonym="فارسی" data-language-local-name="persană" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Puhdistuma" title="Puhdistuma – finlandeză" lang="fi" hreflang="fi" data-title="Puhdistuma" data-language-autonym="Suomi" data-language-local-name="finlandeză" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Clairance_(biologie)" title="Clairance (biologie) – franceză" lang="fr" hreflang="fr" data-title="Clairance (biologie)" data-language-autonym="Français" data-language-local-name="franceză" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Laju_ekskresi_renal" title="Laju ekskresi renal – indoneziană" lang="id" hreflang="id" data-title="Laju ekskresi renal" data-language-autonym="Bahasa Indonesia" data-language-local-name="indoneziană" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Clearance" title="Clearance – italiană" lang="it" hreflang="it" data-title="Clearance" data-language-autonym="Italiano" data-language-local-name="italiană" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%82%AF%E3%83%AA%E3%82%A2%E3%83%A9%E3%83%B3%E3%82%B9_(%E8%96%AC%E7%90%86%E5%AD%A6)" title="クリアランス (薬理学) – japoneză" lang="ja" hreflang="ja" data-title="クリアランス (薬理学)" data-language-autonym="日本語" data-language-local-name="japoneză" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EC%B2%AD%EC%86%8C%EC%9C%A8_(%EC%95%BD%EB%A6%AC%ED%95%99)" title="청소율 (약리학) – coreeană" lang="ko" hreflang="ko" data-title="청소율 (약리학)" data-language-autonym="한국어" data-language-local-name="coreeană" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Klaring_(medisch)" title="Klaring (medisch) – neerlandeză" lang="nl" hreflang="nl" data-title="Klaring (medisch)" data-language-autonym="Nederlands" data-language-local-name="neerlandeză" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-no mw-list-item"><a href="https://no.wikipedia.org/wiki/Clearance" title="Clearance – norvegiană bokmål" lang="nb" hreflang="nb" data-title="Clearance" data-language-autonym="Norsk bokmål" data-language-local-name="norvegiană bokmål" class="interlanguage-link-target"><span>Norsk bokmål</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Klirens" title="Klirens – poloneză" lang="pl" hreflang="pl" data-title="Klirens" data-language-autonym="Polski" data-language-local-name="poloneză" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Depura%C3%A7%C3%A3o_plasm%C3%A1tica" title="Depuração plasmática – portugheză" lang="pt" hreflang="pt" data-title="Depuração plasmática" data-language-autonym="Português" data-language-local-name="portugheză" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%9A%D0%BB%D0%B8%D1%80%D0%B5%D0%BD%D1%81_(%D0%BC%D0%B5%D0%B4%D0%B8%D1%86%D0%B8%D0%BD%D0%B0)" title="Клиренс (медицина) – rusă" lang="ru" hreflang="ru" data-title="Клиренс (медицина)" data-language-autonym="Русский" data-language-local-name="rusă" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Klirens" title="Klirens – sârbo-croată" lang="sh" hreflang="sh" data-title="Klirens" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="sârbo-croată" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Iz%C4%8Distek" title="Izčistek – slovenă" lang="sl" hreflang="sl" data-title="Izčistek" data-language-autonym="Slovenščina" data-language-local-name="slovenă" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Klirens" title="Klirens – sârbă" lang="sr" hreflang="sr" data-title="Klirens" data-language-autonym="Српски / srpski" data-language-local-name="sârbă" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Clearance" title="Clearance – suedeză" lang="sv" hreflang="sv" data-title="Clearance" data-language-autonym="Svenska" data-language-local-name="suedeză" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%9A%D0%BB%D1%96%D1%80%D0%B5%D0%BD%D1%81_(%D0%BC%D0%B5%D0%B4%D0%B8%D1%86%D0%B8%D0%BD%D0%B0)" title="Кліренс (медицина) – ucraineană" lang="uk" hreflang="uk" data-title="Кліренс (медицина)" data-language-autonym="Українська" data-language-local-name="ucraineană" class="interlanguage-link-target"><span>Українська</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q1163287#sitelinks-wikipedia" title="Modifică legăturile interlinguale" class="wbc-editpage">Modifică legăturile</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Spații de nume"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Clearance_plasmatic" title="Vedeți conținutul paginii [a]" accesskey="a"><span>Articol</span></a></li><li id="ca-talk" class="vector-tab-noicon mw-list-item"><a href="/wiki/Discu%C8%9Bie:Clearance_plasmatic" rel="discussion" title="Discuții despre această pagină [t]" accesskey="t"><span>Discuție</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown emptyPortlet" > <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-variants-dropdown" class="vector-dropdown-checkbox " aria-label="Change language variant" > <label id="vector-variants-dropdown-label" for="vector-variants-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">română</span> </label> <div class="vector-dropdown-content"> <div id="p-variants" class="vector-menu mw-portlet mw-portlet-variants emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> </div> </div> </nav> </div> <div id="right-navigation" class="vector-collapsible"> <nav aria-label="Vizualizări"> <div id="p-views" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-views" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-view" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Clearance_plasmatic"><span>Lectură</span></a></li><li id="ca-ve-edit" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Clearance_plasmatic&veaction=edit" title="Modificați această pagină cu EditorulVizual [v]" accesskey="v"><span>Modificare</span></a></li><li id="ca-edit" class="collapsible vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Clearance_plasmatic&action=edit" title="Modificați codul sursă al acestei pagini [e]" accesskey="e"><span>Modificare sursă</span></a></li><li id="ca-history" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Clearance_plasmatic&action=history" title="Versiunile anterioare ale paginii și autorii lor. [h]" accesskey="h"><span>Istoric</span></a></li> </ul> </div> </div> </nav> <nav class="vector-page-tools-landmark" aria-label="Page tools"> <div id="vector-page-tools-dropdown" class="vector-dropdown vector-page-tools-dropdown" > <input type="checkbox" id="vector-page-tools-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-tools-dropdown" class="vector-dropdown-checkbox " aria-label="Unelte" > <label id="vector-page-tools-dropdown-label" for="vector-page-tools-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">Unelte</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-tools-unpinned-container" class="vector-unpinned-container"> <div id="vector-page-tools" class="vector-page-tools vector-pinnable-element"> <div class="vector-pinnable-header vector-page-tools-pinnable-header vector-pinnable-header-unpinned" data-feature-name="page-tools-pinned" data-pinnable-element-id="vector-page-tools" data-pinned-container-id="vector-page-tools-pinned-container" data-unpinned-container-id="vector-page-tools-unpinned-container" > <div class="vector-pinnable-header-label">Unelte</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-page-tools.pin">mută în bara laterală</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-page-tools.unpin">ascunde</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="Mai multe opțiuni" > <div class="vector-menu-heading"> Acțiuni </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected vector-more-collapsible-item mw-list-item"><a href="/wiki/Clearance_plasmatic"><span>Lectură</span></a></li><li id="ca-more-ve-edit" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Clearance_plasmatic&veaction=edit" title="Modificați această pagină cu EditorulVizual [v]" accesskey="v"><span>Modificare</span></a></li><li id="ca-more-edit" class="collapsible vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Clearance_plasmatic&action=edit" title="Modificați codul sursă al acestei pagini [e]" accesskey="e"><span>Modificare sursă</span></a></li><li id="ca-more-history" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Clearance_plasmatic&action=history"><span>Istoric</span></a></li> </ul> </div> </div> <div id="p-tb" class="vector-menu mw-portlet mw-portlet-tb" > <div class="vector-menu-heading"> General </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-whatlinkshere" class="mw-list-item"><a href="/wiki/Special:Ce_se_leag%C4%83_aici/Clearance_plasmatic" title="Lista tuturor paginilor wiki care conduc spre această pagină [j]" accesskey="j"><span>Ce trimite aici</span></a></li><li id="t-recentchangeslinked" class="mw-list-item"><a href="/wiki/Special:Modific%C4%83ri_corelate/Clearance_plasmatic" rel="nofollow" title="Schimbări recente în legătură cu această pagină [k]" accesskey="k"><span>Schimbări corelate</span></a></li><li id="t-upload" class="mw-list-item"><a href="/wiki/Wikipedia:Trimite_fi%C8%99ier" title="Încărcare fișiere [u]" accesskey="u"><span>Trimite fișier</span></a></li><li id="t-specialpages" class="mw-list-item"><a href="/wiki/Special:Pagini_speciale" title="Lista tuturor paginilor speciale [q]" accesskey="q"><span>Pagini speciale</span></a></li><li id="t-permalink" class="mw-list-item"><a href="/w/index.php?title=Clearance_plasmatic&oldid=16340091" title="Legătură permanentă către această versiune a acestei pagini"><span>Legătură 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dir="ltr"><p><b>Clearence-ul plasmatic</b> reprezintă un parametru <a href="/wiki/Farmacocinetic%C4%83" title="Farmacocinetică">farmacocinetic</a> prin care se măsoară viteza de epurare a unui medicament în funcție de concentrația medicamentelor în lichidele biologice. </p><p>În mod eronat se definește ca fiind cantitatea de lichid filtrată în afara compartimentului sanguin, la nivelul rinichiului, sau cantitatea de sînge filtrată pe unitatea de timp, motivul fiind unitatea de măsura volum/timp. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Exprimarea_matematică"><span id="Exprimarea_matematic.C4.83"></span>Exprimarea matematică</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Clearance_plasmatic&veaction=edit&section=1" title="Modifică secțiunea: Exprimarea matematică" class="mw-editsection-visualeditor"><span>modificare</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Clearance_plasmatic&action=edit&section=1" title="Edit section's source code: Exprimarea matematică"><span>modificare sursă</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><span class="mwe-math-element"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle V{\frac {dC}{dt}}=-K\cdot C+{\dot {n}}\qquad (1)}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <mi>V</mi> <mrow class="MJX-TeXAtom-ORD"> <mfrac> <mrow> <mi>d</mi> <mi>C</mi> </mrow> <mrow> <mi>d</mi> <mi>t</mi> </mrow> </mfrac> </mrow> <mo>=</mo> <mo>−</mo> <mi>K</mi> <mo>⋅</mo> <mi>C</mi> <mo>+</mo> <mrow class="MJX-TeXAtom-ORD"> <mrow class="MJX-TeXAtom-ORD"> <mover> <mi>n</mi> <mo>˙</mo> </mover> </mrow> </mrow> <mspace width="2em" /> <mo stretchy="false">(</mo> <mn>1</mn> <mo stretchy="false">)</mo> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle V{\frac {dC}{dt}}=-K\cdot C+{\dot {n}}\qquad (1)}</annotation> </semantics> </math></span><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/c20d8a236334fa5af1bb66bbe18f8ef12be3f4c1" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -2.005ex; width:27.876ex; height:5.509ex;" alt="{\displaystyle V{\frac {dC}{dt}}=-K\cdot C+{\dot {n}}\qquad (1)}"></span> </p><p>Unde: </p> <ul><li><span class="mwe-math-element"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle {\dot {n}}}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <mrow class="MJX-TeXAtom-ORD"> <mrow class="MJX-TeXAtom-ORD"> <mover> <mi>n</mi> <mo>˙</mo> </mover> </mrow> </mrow> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle {\dot {n}}}</annotation> </semantics> </math></span><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/b37bd5affb89d1eebc9c84c22127061fce5f69e7" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.338ex; width:1.395ex; height:2.176ex;" alt="{\displaystyle {\dot {n}}}"></span> rata de generare a substanței, considerată o constantă;unitate de măsură [mmol/min] sau [mol/s]</li> <li>t este timpul de dializă sau timpul de la injecția administrată ; unitate de măsură [min] sau [s]</li> <li>V <a href="/wiki/Volumul_de_distribu%C8%9Bie" class="mw-redirect" title="Volumul de distribuție">volum de distribuție</a>, sau apa totală din corp; unitate de măsură [L] sau [m<sup>3</sup>]</li> <li>K clearance-ul, unitate de măsură [mL/min] sau [m<sup>3</sup>/s]</li> <li>C <a href="/wiki/Concentra%C8%9Bie_molar%C4%83" title="Concentrație molară">concentrația</a> substanței exprimată în [mol/L] sau [mol/m<sup>3</sup>]</li></ul> <p>Prin integrare a <span class="mwe-math-element"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle {\frac {dC}{dt}}}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <mrow class="MJX-TeXAtom-ORD"> <mfrac> <mrow> <mi>d</mi> <mi>C</mi> </mrow> <mrow> <mi>d</mi> <mi>t</mi> </mrow> </mfrac> </mrow> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle {\frac {dC}{dt}}}</annotation> </semantics> </math></span><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/f2fa41912219f104c9541dce3706e52c089a016c" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -2.005ex; width:3.818ex; height:5.509ex;" alt="{\displaystyle {\frac {dC}{dt}}}"></span>, se obține o ecuație care arată variația concentrației în timp. (<i>1</i>): </p><p><span class="mwe-math-element"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle C={\frac {\dot {m}}{K}}+(C_{o}-{\frac {\dot {m}}{K}})e^{-{\frac {K\cdot t}{V}}}\qquad (2)}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <mi>C</mi> <mo>=</mo> <mrow class="MJX-TeXAtom-ORD"> <mfrac> <mrow class="MJX-TeXAtom-ORD"> <mover> <mi>m</mi> <mo>˙</mo> </mover> </mrow> <mi>K</mi> </mfrac> </mrow> <mo>+</mo> <mo stretchy="false">(</mo> <msub> <mi>C</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>o</mi> </mrow> </msub> <mo>−</mo> <mrow class="MJX-TeXAtom-ORD"> <mfrac> <mrow class="MJX-TeXAtom-ORD"> <mover> <mi>m</mi> <mo>˙</mo> </mover> </mrow> <mi>K</mi> </mfrac> </mrow> <mo stretchy="false">)</mo> <msup> <mi>e</mi> <mrow class="MJX-TeXAtom-ORD"> <mo>−</mo> <mrow class="MJX-TeXAtom-ORD"> <mfrac> <mrow> <mi>K</mi> <mo>⋅</mo> <mi>t</mi> </mrow> <mi>V</mi> </mfrac> </mrow> </mrow> </msup> <mspace width="2em" /> <mo stretchy="false">(</mo> <mn>2</mn> <mo stretchy="false">)</mo> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle C={\frac {\dot {m}}{K}}+(C_{o}-{\frac {\dot {m}}{K}})e^{-{\frac {K\cdot t}{V}}}\qquad (2)}</annotation> </semantics> </math></span><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/cddb178192cbccddf8f2782586625c5559e05f36" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -1.838ex; width:33.937ex; height:5.176ex;" alt="{\displaystyle C={\frac {\dot {m}}{K}}+(C_{o}-{\frac {\dot {m}}{K}})e^{-{\frac {K\cdot t}{V}}}\qquad (2)}"></span><sup><span id="ref_Gotch1998" class="plainlinks"><a class="external autonumber" href="https://ro.wikipedia.org/wiki/Clearance_plasmatic#endnote_Gotch1998">[1]</a></span></sup><sup><span id="ref_Gotch2000" class="plainlinks"><a class="external autonumber" href="https://ro.wikipedia.org/wiki/Clearance_plasmatic#endnote_Gotch2000">[2]</a></span></sup> </p><p>Unde </p> <ul><li>C<sub>o</sub> concentrația la începutul procesului de <a href="/wiki/Dializ%C4%83" class="mw-redirect" title="Dializă">dializă</a>, sau concentrația inițială de substanță după <a href="/wiki/Distribu%C8%9Bia" class="mw-redirect" title="Distribuția">distribuție</a>,exprimată în [mmol/L] sau [mol/m<sup>3</sup>]</li> <li><a href="/wiki/E_(constant%C4%83_matematic%C4%83)" title="E (constantă matematică)">e</a> baza <a href="/wiki/Logaritm_natural" title="Logaritm natural">logaritmului natural</a></li></ul> <p>Soluția ecuației diferențiale la timp infinit (<a href="/wiki/Stare_sta%C8%9Bionar%C4%83" title="Stare staționară">stare staționară</a>) este: </p><p><span class="mwe-math-element"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle C_{\infty }={\frac {\dot {m}}{K}}\qquad (3a)}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <msub> <mi>C</mi> <mrow class="MJX-TeXAtom-ORD"> <mi mathvariant="normal">∞</mi> </mrow> </msub> <mo>=</mo> <mrow class="MJX-TeXAtom-ORD"> <mfrac> <mrow class="MJX-TeXAtom-ORD"> <mover> <mi>m</mi> <mo>˙</mo> </mover> </mrow> <mi>K</mi> </mfrac> </mrow> <mspace width="2em" /> <mo stretchy="false">(</mo> <mn>3</mn> <mi>a</mi> <mo stretchy="false">)</mo> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle C_{\infty }={\frac {\dot {m}}{K}}\qquad (3a)}</annotation> </semantics> </math></span><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/e9be1f803ef40093b23ae6791abaa403b2a752cb" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -1.838ex; width:18.384ex; height:5.176ex;" alt="{\displaystyle C_{\infty }={\frac {\dot {m}}{K}}\qquad (3a)}"></span> sau <span class="mwe-math-element"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle K={\frac {\dot {m}}{C_{\infty }}}\qquad (3b)}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <mi>K</mi> <mo>=</mo> <mrow class="MJX-TeXAtom-ORD"> <mfrac> <mrow class="MJX-TeXAtom-ORD"> <mover> <mi>m</mi> <mo>˙</mo> </mover> </mrow> <msub> <mi>C</mi> <mrow class="MJX-TeXAtom-ORD"> <mi mathvariant="normal">∞</mi> </mrow> </msub> </mfrac> </mrow> <mspace width="2em" /> <mo stretchy="false">(</mo> <mn>3</mn> <mi>b</mi> <mo stretchy="false">)</mo> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle K={\frac {\dot {m}}{C_{\infty }}}\qquad (3b)}</annotation> </semantics> </math></span><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/4e76d028d4f9f8bdc30c6b09847cce97a2c05474" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -2.338ex; width:18.152ex; height:5.676ex;" alt="{\displaystyle K={\frac {\dot {m}}{C_{\infty }}}\qquad (3b)}"></span> </p><p>Ecuația (<i>3b</i>) arată clar relația dintre cantitatea dezlocuită și clearance, anume proporționalitatea inversă una față de cealaltă. Dacă este aplicată la <a href="/wiki/Creatinin%C4%83" title="Creatinină">creatinină</a> (<a href="/w/index.php?title=Clearance-ul_creatininei&action=edit&redlink=1" class="new" title="Clearance-ul creatininei — pagină inexistentă">clearance-ul creatininei</a>) urmează ecuația conform căreia dacă valoarea creatininei serice crește de 2 ori, clearance-ul se înjumătățește, iar dacă creatinina serică crește de 4 ori, clearance-ul scade de 4 ori. </p> <div class="mw-heading mw-heading2"><h2 id="Tipuri_de_clearance">Tipuri de clearance</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Clearance_plasmatic&veaction=edit&section=2" title="Modifică secțiunea: Tipuri de clearance" class="mw-editsection-visualeditor"><span>modificare</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Clearance_plasmatic&action=edit&section=2" title="Edit section's source code: Tipuri de clearance"><span>modificare sursă</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Clearance-ul_sistemic_total_ClT">Clearance-ul sistemic total Cl<sub>T</sub></h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Clearance_plasmatic&veaction=edit&section=3" title="Modifică secțiunea: Clearance-ul sistemic total ClT" class="mw-editsection-visualeditor"><span>modificare</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Clearance_plasmatic&action=edit&section=3" title="Edit section's source code: Clearance-ul sistemic total ClT"><span>modificare sursă</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Este suma tuturor proceselor care intervin în epurarea unui medicament din organism: </p><p><span class="mwe-math-element"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle Cl_{t}=\sum Cl_{M}+Cl_{E}=Cl_{H}+Cl_{R}+Cl_{B}}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <mi>C</mi> <msub> <mi>l</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>t</mi> </mrow> </msub> <mo>=</mo> <mo>∑</mo> <mi>C</mi> <msub> <mi>l</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>M</mi> </mrow> </msub> <mo>+</mo> <mi>C</mi> <msub> <mi>l</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>E</mi> </mrow> </msub> <mo>=</mo> <mi>C</mi> <msub> <mi>l</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>H</mi> </mrow> </msub> <mo>+</mo> <mi>C</mi> <msub> <mi>l</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>R</mi> </mrow> </msub> <mo>+</mo> <mi>C</mi> <msub> <mi>l</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>B</mi> </mrow> </msub> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle Cl_{t}=\sum Cl_{M}+Cl_{E}=Cl_{H}+Cl_{R}+Cl_{B}}</annotation> </semantics> </math></span><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/c57355d72b4124617caa046134177c4dddb6e3ef" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -1.338ex; width:42.142ex; height:3.843ex;" alt="{\displaystyle Cl_{t}=\sum Cl_{M}+Cl_{E}=Cl_{H}+Cl_{R}+Cl_{B}}"></span> </p> <ul><li>Cl<sub>M</sub> clearance-ul de metabolizare</li> <li>Cl<sub>E</sub> clearance-ul de eliminare</li> <li>Cl<sub>H</sub> clearance-ul hepatic</li> <li>Cl<sub>R</sub> clearance-ul renal</li> <li>Cl<sub>B</sub> clearance-ul biliar</li></ul> <p>Clearance-ul total este volumul de distribuție epurat pe unitatea de timp: </p><p><span class="mwe-math-element"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle Cl_{T}={K_{e}}\times V_{d}\to \ V_{d}={\frac {Cl_{T}}{K_{e}}}\to \ K_{e}={\frac {Cl_{T}}{V_{d}}}}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <mi>C</mi> <msub> <mi>l</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>T</mi> </mrow> </msub> <mo>=</mo> <mrow class="MJX-TeXAtom-ORD"> <msub> <mi>K</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>e</mi> </mrow> </msub> </mrow> <mo>×</mo> <msub> <mi>V</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>d</mi> </mrow> </msub> <mo stretchy="false">→</mo> <mtext> </mtext> <msub> <mi>V</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>d</mi> </mrow> </msub> <mo>=</mo> <mrow class="MJX-TeXAtom-ORD"> <mfrac> <mrow> <mi>C</mi> <msub> <mi>l</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>T</mi> </mrow> </msub> </mrow> <msub> <mi>K</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>e</mi> </mrow> </msub> </mfrac> </mrow> <mo stretchy="false">→</mo> <mtext> </mtext> <msub> <mi>K</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>e</mi> </mrow> </msub> <mo>=</mo> <mrow class="MJX-TeXAtom-ORD"> <mfrac> <mrow> <mi>C</mi> <msub> <mi>l</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>T</mi> </mrow> </msub> </mrow> <msub> <mi>V</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>d</mi> </mrow> </msub> </mfrac> </mrow> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle Cl_{T}={K_{e}}\times V_{d}\to \ V_{d}={\frac {Cl_{T}}{K_{e}}}\to \ K_{e}={\frac {Cl_{T}}{V_{d}}}}</annotation> </semantics> </math></span><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/8e952e3db641ecf21b0804cfb332a491af6bb133" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -2.338ex; width:44.582ex; height:5.843ex;" alt="{\displaystyle Cl_{T}={K_{e}}\times V_{d}\to \ V_{d}={\frac {Cl_{T}}{K_{e}}}\to \ K_{e}={\frac {Cl_{T}}{V_{d}}}}"></span> (<b>a</b>) </p><p><span class="mwe-math-element"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle Cl_{T}={\frac {ln2}{T_{1/2}}}\times V_{d}={\frac {0,693}{T_{1/2}}}\times V_{d}\to \ V_{d}={\frac {Cl_{T}}{0,693}}\times T_{1/2}}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <mi>C</mi> <msub> <mi>l</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>T</mi> </mrow> </msub> <mo>=</mo> <mrow class="MJX-TeXAtom-ORD"> <mfrac> <mrow> <mi>l</mi> <mi>n</mi> <mn>2</mn> </mrow> <msub> <mi>T</mi> <mrow class="MJX-TeXAtom-ORD"> <mn>1</mn> <mrow class="MJX-TeXAtom-ORD"> <mo>/</mo> </mrow> <mn>2</mn> </mrow> </msub> </mfrac> </mrow> <mo>×</mo> <msub> <mi>V</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>d</mi> </mrow> </msub> <mo>=</mo> <mrow class="MJX-TeXAtom-ORD"> <mfrac> <mrow> <mn>0</mn> <mo>,</mo> <mn>693</mn> </mrow> <msub> <mi>T</mi> <mrow class="MJX-TeXAtom-ORD"> <mn>1</mn> <mrow class="MJX-TeXAtom-ORD"> <mo>/</mo> </mrow> <mn>2</mn> </mrow> </msub> </mfrac> </mrow> <mo>×</mo> <msub> <mi>V</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>d</mi> </mrow> </msub> <mo stretchy="false">→</mo> <mtext> </mtext> <msub> <mi>V</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>d</mi> </mrow> </msub> <mo>=</mo> <mrow class="MJX-TeXAtom-ORD"> <mfrac> <mrow> <mi>C</mi> <msub> <mi>l</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>T</mi> </mrow> </msub> </mrow> <mrow> <mn>0</mn> <mo>,</mo> <mn>693</mn> </mrow> </mfrac> </mrow> <mo>×</mo> <msub> <mi>T</mi> <mrow class="MJX-TeXAtom-ORD"> <mn>1</mn> <mrow class="MJX-TeXAtom-ORD"> <mo>/</mo> </mrow> <mn>2</mn> </mrow> </msub> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle Cl_{T}={\frac {ln2}{T_{1/2}}}\times V_{d}={\frac {0,693}{T_{1/2}}}\times V_{d}\to \ V_{d}={\frac {Cl_{T}}{0,693}}\times T_{1/2}}</annotation> </semantics> </math></span><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/79742b52810f42bd88206fec53f771d050a364df" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -2.671ex; width:55.189ex; height:6.176ex;" alt="{\displaystyle Cl_{T}={\frac {ln2}{T_{1/2}}}\times V_{d}={\frac {0,693}{T_{1/2}}}\times V_{d}\to \ V_{d}={\frac {Cl_{T}}{0,693}}\times T_{1/2}}"></span> (<b>b</b>) </p><p>Din a și b rezultă </p> <dl><dd><dl><dd><span class="mwe-math-element"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle T_{12}={\frac {0,693}{Cl_{T}}}\times V_{d}={\frac {0,693}{K_{e}}}}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <msub> <mi>T</mi> <mrow class="MJX-TeXAtom-ORD"> <mn>12</mn> </mrow> </msub> <mo>=</mo> <mrow class="MJX-TeXAtom-ORD"> <mfrac> <mrow> <mn>0</mn> <mo>,</mo> <mn>693</mn> </mrow> <mrow> <mi>C</mi> <msub> <mi>l</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>T</mi> </mrow> </msub> </mrow> </mfrac> </mrow> <mo>×</mo> <msub> <mi>V</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>d</mi> </mrow> </msub> <mo>=</mo> <mrow class="MJX-TeXAtom-ORD"> <mfrac> <mrow> <mn>0</mn> <mo>,</mo> <mn>693</mn> </mrow> <msub> <mi>K</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>e</mi> </mrow> </msub> </mfrac> </mrow> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle T_{12}={\frac {0,693}{Cl_{T}}}\times V_{d}={\frac {0,693}{K_{e}}}}</annotation> </semantics> </math></span><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/043c760e7f84aca0f3f03d5c5f1173a196dc083f" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -2.338ex; width:27.758ex; height:5.843ex;" alt="{\displaystyle T_{12}={\frac {0,693}{Cl_{T}}}\times V_{d}={\frac {0,693}{K_{e}}}}"></span></dd></dl></dd></dl> <ul><li>K<sub>e</sub> constanta de eliminare</li> <li>T<sub>1/2</sub> timpul de înjumătățire</li> <li>V<sub>d</sub> volumul de distribuție</li></ul> <div class="mw-heading mw-heading3"><h3 id="Clearance-ul_plasmatic_Clp">Clearance-ul plasmatic Cl<sub>p</sub></h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Clearance_plasmatic&veaction=edit&section=4" title="Modifică secțiunea: Clearance-ul plasmatic Clp" class="mw-editsection-visualeditor"><span>modificare</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Clearance_plasmatic&action=edit&section=4" title="Edit section's source code: Clearance-ul plasmatic Clp"><span>modificare sursă</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Clearance-ul plasmatic reprezintă volumul de plasmă din care este epurat medicamentul pe unitatea de timp: </p> <dl><dd><span class="mwe-math-element"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle Cl_{p}={\frac {C_{A}-C_{V}}{C_{A}}}\times Q}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <mi>C</mi> <msub> <mi>l</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>p</mi> </mrow> </msub> <mo>=</mo> <mrow class="MJX-TeXAtom-ORD"> <mfrac> <mrow> <msub> <mi>C</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>A</mi> </mrow> </msub> <mo>−</mo> <msub> <mi>C</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>V</mi> </mrow> </msub> </mrow> <msub> <mi>C</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>A</mi> </mrow> </msub> </mfrac> </mrow> <mo>×</mo> <mi>Q</mi> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle Cl_{p}={\frac {C_{A}-C_{V}}{C_{A}}}\times Q}</annotation> </semantics> </math></span><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/4a6f245ec54cb88af145fbe1f662453623a5a82f" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -2.338ex; width:21.257ex; height:5.843ex;" alt="{\displaystyle Cl_{p}={\frac {C_{A}-C_{V}}{C_{A}}}\times Q}"></span></dd></dl> <ul><li>Q <a href="/wiki/Debit" class="mw-redirect" title="Debit">debitul</a> sanguin</li> <li>C<sub>A</sub> concentrația la nivel arterial</li> <li>C<sub>V</sub> concentrația la nivel venos</li></ul> <p>El are 2 parametri: </p> <ul><li>Viteza de extracție plasmatică</li></ul> <p><span class="mwe-math-element"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle V_{E}=Q\times (C_{A}-C_{V})}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <msub> <mi>V</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>E</mi> </mrow> </msub> <mo>=</mo> <mi>Q</mi> <mo>×</mo> <mo stretchy="false">(</mo> <msub> <mi>C</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>A</mi> </mrow> </msub> <mo>−</mo> <msub> <mi>C</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>V</mi> </mrow> </msub> <mo stretchy="false">)</mo> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle V_{E}=Q\times (C_{A}-C_{V})}</annotation> </semantics> </math></span><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/80c9dadde24b96fd7bcbc8a5dc355b370715b44f" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -0.838ex; width:21.554ex; height:2.843ex;" alt="{\displaystyle V_{E}=Q\times (C_{A}-C_{V})}"></span> </p> <ul><li>Coeficientul de extracție E</li></ul> <p><span class="mwe-math-element"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle E={\frac {C_{A}-C_{V}}{C_{A}}}}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <mi>E</mi> <mo>=</mo> <mrow class="MJX-TeXAtom-ORD"> <mfrac> <mrow> <msub> <mi>C</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>A</mi> </mrow> </msub> <mo>−</mo> <msub> <mi>C</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>V</mi> </mrow> </msub> </mrow> <msub> <mi>C</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>A</mi> </mrow> </msub> </mfrac> </mrow> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle E={\frac {C_{A}-C_{V}}{C_{A}}}}</annotation> </semantics> </math></span><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/bffdd16cd57bc463507a4bab0fa399aaf034968c" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -2.338ex; width:14.835ex; height:5.843ex;" alt="{\displaystyle E={\frac {C_{A}-C_{V}}{C_{A}}}}"></span> </p> <div class="mw-heading mw-heading3"><h3 id="Clearance-ul_unui_organ_de_epurare_Clorg">Clearance-ul unui organ de epurare Cl<sub>org</sub></h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Clearance_plasmatic&veaction=edit&section=5" title="Modifică secțiunea: Clearance-ul unui organ de epurare Clorg" class="mw-editsection-visualeditor"><span>modificare</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Clearance_plasmatic&action=edit&section=5" title="Edit section's source code: Clearance-ul unui organ de epurare Clorg"><span>modificare sursă</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li>hepatic Cl<sub>H</sub></li> <li>renal Cl<sub>R</sub></li></ul> <p>Clearance-ul renal este măsurat prin colectarea urinii pe o perioadă de timp, și analiza acesteia cu ajutorul ecuației derivate din (<i>3b</i>): </p><p><span class="mwe-math-element"><span class="mwe-math-mathml-inline mwe-math-mathml-a11y" style="display: none;"><math xmlns="http://www.w3.org/1998/Math/MathML" alttext="{\displaystyle Cl={\frac {C_{U}\cdot Q}{C_{B}}}\qquad (4)}"> <semantics> <mrow class="MJX-TeXAtom-ORD"> <mstyle displaystyle="true" scriptlevel="0"> <mi>C</mi> <mi>l</mi> <mo>=</mo> <mrow class="MJX-TeXAtom-ORD"> <mfrac> <mrow> <msub> <mi>C</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>U</mi> </mrow> </msub> <mo>⋅</mo> <mi>Q</mi> </mrow> <msub> <mi>C</mi> <mrow class="MJX-TeXAtom-ORD"> <mi>B</mi> </mrow> </msub> </mfrac> </mrow> <mspace width="2em" /> <mo stretchy="false">(</mo> <mn>4</mn> <mo stretchy="false">)</mo> </mstyle> </mrow> <annotation encoding="application/x-tex">{\displaystyle Cl={\frac {C_{U}\cdot Q}{C_{B}}}\qquad (4)}</annotation> </semantics> </math></span><img src="https://wikimedia.org/api/rest_v1/media/math/render/svg/3454326696148236374291acfc99dc70e6e11aee" class="mwe-math-fallback-image-inline mw-invert skin-invert" aria-hidden="true" style="vertical-align: -2.338ex; width:20.683ex; height:5.843ex;" alt="{\displaystyle Cl={\frac {C_{U}\cdot Q}{C_{B}}}\qquad (4)}"></span> </p> <ul><li>Cl clearance-ul [mL/min]</li> <li>C<sub>U</sub> concentrația urinii [mmol/L]</li> <li>Q volumul urinii (volum/timp) [mL/min] ( mai des[mL/24 hours])</li> <li>C<sub>B</sub> concentrația plasmatică [mmol/mL]</li></ul> <p>Ecuația (<i>4</i>) este valabilă doar pentru starea "steady-state" (stare de echilibru). Dacă substanța epurată nu are o concentrație constantă, clearence-ul se obține din ecuația 2. </p> <ul><li>biliar</li></ul> <div class="mw-heading mw-heading3"><h3 id="Clearance-ul_intrinsec">Clearance-ul intrinsec</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Clearance_plasmatic&veaction=edit&section=6" title="Modifică secțiunea: Clearance-ul intrinsec" class="mw-editsection-visualeditor"><span>modificare</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Clearance_plasmatic&action=edit&section=6" title="Edit section's source code: Clearance-ul intrinsec"><span>modificare sursă</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading2"><h2 id="Bibliografie">Bibliografie</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Clearance_plasmatic&veaction=edit&section=7" title="Modifică secțiunea: Bibliografie" class="mw-editsection-visualeditor"><span>modificare</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Clearance_plasmatic&action=edit&section=7" title="Edit section's source code: Bibliografie"><span>modificare sursă</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li>V. Ranga; I. Teodorescu Exarcu. <i>Anatomia și fiziologia omului</i>, Editura Medicală, București 1970</li></ul> <p><a class="external free" href="https://en.wikipedia.org/wiki/Renal_clearance">http://en.wikipedia.org/wiki/Renal_clearance</a> </p> <div class="mw-heading mw-heading2"><h2 id="Referințe"><span id="Referin.C8.9Be"></span>Referințe</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Clearance_plasmatic&veaction=edit&section=8" title="Modifică secțiunea: Referințe" class="mw-editsection-visualeditor"><span>modificare</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Clearance_plasmatic&action=edit&section=8" title="Edit section's source code: Referințe"><span>modificare sursă</span></a><span class="mw-editsection-bracket">]</span></span></div> <ol><li><span class="citation wikicite" id="endnote_Babb"><b><a href="#ref_Babb">^</a></b></span>Babb AL, Popovich RP, Christopher TG, Scribner BH. The genesis of the square meter-hour hypothesis. Trans Am Soc Artif Intern Organs. 1971;17:81-91. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/5158139?dopt=Abstract">PMID 5158139</a></li> <li><span class="citation wikicite" id="endnote_Gotch1998"><b><a href="#ref_Gotch1998">^</a></b></span>Gotch FA. The current place of urea kinetic modelling with respect to different dialysis modalities. Nephrol Dial Transplant. 1998;13 Suppl 6:10-4. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/9719197?dopt=Abstract">PMID 9719197</a> <a rel="nofollow" class="external text" href="http://ndt.oxfordjournals.org/cgi/reprint/13/suppl_6/10">Full Text</a></li> <li><span class="citation wikicite" id="endnote_Gotch2000"><b><a href="#ref_Gotch2000">^</a></b></span>Gotch FA, Sargent JA, Keen ML. Whither goest Kt/V? Kidney Int Suppl. 2000 Aug;76:S3-18. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/10936795?dopt=Abstract">PMID 10936795</a></li></ol> <p><br /> </p> <table class="navbox" cellspacing="0" style=""> <tbody><tr> <td style="padding:2px;"> <table cellspacing="0" class="nowraplinks collapsible autocollapse" style="width:100%;background:transparent;color:inherit;;"> <tbody><tr> <th style=";" colspan="3" class="navbox-title"><div style="float:left; width:6em;text-align:left;"><div class="noprint plainlinks" style="padding:0; font-size:xx-small; color:var(--color-base, #000); white-space:nowrap; ;"><span style=";;border:none;"><a href="/wiki/Format:Farmacologie" title="Format:Farmacologie"><span title="Vizualizare format" style=";;border:none;;">v</span></a> <span style="font-size:80%;">•</span> <a href="/wiki/Discu%C8%9Bie_Format:Farmacologie" title="Discuție Format:Farmacologie"><span title="Discuție format" style=";;border:none;;">d</span></a> <span style="font-size:80%;">•</span> <a class="external text" href="https://ro.wikipedia.org/w/index.php?title=Format:Farmacologie&action=edit"><span title="Acest format se poate modifica. 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