Research Group Torsten Schwede

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title="Markus Rüegg" class="list-link color-dark-grey"> Markus Rüegg <span class="icon-arrow-right"></span> </a> </p> </li> <li class="list-item "> <p> <a href="/research/research-groups/research-groups-a-z/overview/unit/research-group-peter-scheiffele" title="Peter Scheiffele" class="list-link color-dark-grey"> Peter Scheiffele <span class="icon-arrow-right"></span> </a> </p> </li> <li class="list-item "> <p> <a href="/research/research-groups/research-groups-a-z/overview/unit/research-group-alex-schier" title="Alex Schier" class="list-link color-dark-grey"> Alex Schier <span class="icon-arrow-right"></span> </a> </p> </li> <li class="list-item "> <p> <a href="/research/research-groups/research-groups-a-z/overview/unit/research-group-torsten-schwede" title="Torsten Schwede" class="list-link color-dark-grey"> Torsten Schwede <span class="icon-arrow-right"></span> </a> </p> </li> <li class="list-item "> <p> <a href="/research/research-groups/research-groups-a-z/overview/unit/research-group-anne-spang" title="Anne Spang" class="list-link color-dark-grey"> Anne Spang <span class="icon-arrow-right"></span> </a> </p> </li> <li class="list-item "> <p> <a href="/research/research-groups/research-groups-a-z/overview/unit/research-group-erik-van-nimwegen" title="Erik van Nimwegen" class="list-link color-dark-grey"> Erik van Nimwegen <span class="icon-arrow-right"></span> </a> </p> </li> <li class="list-item "> <p> <a href="/research/research-groups/research-groups-a-z/overview/unit/research-group-mihaela-zavolan" title="Mihaela Zavolan" class="list-link color-dark-grey"> Mihaela Zavolan <span class="icon-arrow-right"></span> </a> </p> </li> </ul> </li> </ul> </li> <li class="sub-navigation-item sub "> <ul class=""> <li class="sub-navigation-item sub"> <h4> <a class="sub-navigation-link " href="/research/research-groups/research-fields"> Research Fields & Publications </a> </h4> <ul class="list"> <li 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Project Leaders A-Z <span class="icon-arrow-right"></span> </a> </p> </li> <li class="list-item "> <p> <a href="/research/research-groups/postdocs" title="Postdocs" class="list-link color-dark-grey"> Postdocs <span class="icon-arrow-right"></span> </a> </p> </li> <li class="list-item "> <p> <a href="/phd/phd-at-a-glance/overview" title="PhD" class="list-link color-dark-grey"> PhD <span class="icon-arrow-right"></span> </a> </p> </li> <li class="list-item "> <p> <a href="/research/research-groups/professor-views" title="Professor Views" class="list-link color-dark-grey"> Professor Views <span class="icon-arrow-right"></span> </a> </p> </li> <li class="list-item "> <p> <a href="/research/research-groups/women-in-science" title="Women in Science" class="list-link color-dark-grey"> Women in Science <span class="icon-arrow-right"></span> </a> </p> </li> <li class="list-item "> <p> <a href="/emeriti-former-professors/emeriti" title="Emeriti" class="list-link color-dark-grey"> Emeriti <span 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Collaborations" class="list-link color-dark-grey"> Partners & Collaborations <span class="icon-arrow-right"></span> </a> </p> </li> <li class="list-item "> <p> <a href="/research/partners/scientific-networks" title="Scientific Networks" class="list-link color-dark-grey"> Scientific Networks <span class="icon-arrow-right"></span> </a> </p> </li> <li class="list-item "> <p> <a href="/research/partners/titular-professors" title="Honorary Professors" class="list-link color-dark-grey"> Honorary Professors <span class="icon-arrow-right"></span> </a> </p> </li> </ul> </li> </ul> </li> </ul> </div> </li> <li class="main-navigation-item sub"> <h3> <a class="main-navigation-link" href="/phd/phd-at-a-glance/overview"> PhD </a> </h3> <div class="sub-navigation"> <ul class="sub-navigation-items"> <li class="back-navigation"><p><small>Back<span class="icon-arrow-right"></span></small></p></li> <li class="sub-navigation-title-wrapper"> <h2><a href="/phd/phd-at-a-glance/overview" class="sub-navigation-title">Overview</a></h2> </li> <li class="sub-navigation-item sub "> <ul class=""> <li class="sub-navigation-item sub"> <h4> <a class="sub-navigation-link " href="/phd/phd-at-a-glance/overview"> PhD at a Glance </a> </h4> <ul class="list"> <li class="list-item "> <p> <a href="/phd/phd-at-a-glance/overview" title="Overview" class="list-link color-dark-grey"> Overview <span class="icon-arrow-right"></span> </a> </p> </li> </ul> </li> </ul> <ul class=""> <li class="sub-navigation-item sub"> <h4> <a class="sub-navigation-link " href="/phd/phd-student-office/phd-student-office"> PhD Student Office </a> </h4> <ul class="list"> <li class="list-item "> <p> <a href="/phd/phd-student-office/phd-student-office" title="PhD Student Office" class="list-link color-dark-grey"> PhD Student Office <span class="icon-arrow-right"></span> </a> </p> </li> </ul> </li> </ul> </li> <li class="sub-navigation-item sub "> <ul class=""> <li class="sub-navigation-item sub"> <h4> <a class="sub-navigation-link " href="/phd/international-phd-program/phd-program"> International PhD Program </a> </h4> <ul class="list"> <li class="list-item "> <p> <a href="/phd/international-phd-program/phd-program" title="PhD Program" class="list-link color-dark-grey"> PhD Program <span class="icon-arrow-right"></span> </a> </p> </li> <li class="list-item "> <p> <a href="/phd/international-phd-program/phd-fellowships" title="PhD Fellowships" class="list-link color-dark-grey"> PhD Fellowships <span class="icon-arrow-right"></span> </a> </p> </li> <li class="list-item "> <p> <a href="/education/graduate-teaching-program/teaching-cycles" title="Graduate Teaching Program" class="list-link color-dark-grey"> Graduate Teaching Program <span class="icon-arrow-right"></span> </a> </p> </li> <li class="list-item "> <p> <a href="/phd/international-phd-program/phd-documents" title="PhD Documents" class="list-link color-dark-grey"> PhD Documents <span class="icon-arrow-right"></span> </a> </p> 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Professors</span> <span class="icon-arrow-right"></span></a></h5></li></ul></li><li><h4><a href="/research/research-groups/research-fields"><span class="inner-nav-link">Research Fields & Publications</span> <span class="icon-arrow-right"></span></a></h4></li><li><h4><a href="/research/awards-honors/highlights"><span class="inner-nav-link">Awards & Honors</span> <span class="icon-arrow-right"></span></a></h4></li><li><h4><a href="/research/technology-ventures/overview"><span class="inner-nav-link">Technology Ventures</span> <span class="icon-arrow-right"></span></a></h4></li><li><h4><a href="/research/partners/partners-collaborations"><span class="inner-nav-link">Partners</span> <span class="icon-arrow-right"></span></a></h4></li></ul> </div> </div> <section class="section-bgcolor-0 section-default"> <div class="container content-container-bioz"> <div class="tx-x4eresearch"> <div class="hide rootlinename" data-group="Research Group Torsten Schwede" data-rootname="Prof. Dr. Torsten Schwede"></div> <div class="box text-center hasInner"> <div class="inner"> <div class="image"> <picture>  <source media="(min-width: 400px) and (-webkit-min-device-pixel-ratio: 2),(min--moz-device-pixel-ratio: 2),(min-device-pixel-ratio: 2),(-o-min-device-pixel-ratio: 2/1)" srcset="/fileadmin/_processed_/0/9/csm_torsten_schwede_e0cbc2a64c.jpg" />  <source media="(min-width: 400px)" srcset="/fileadmin/_processed_/0/9/csm_torsten_schwede_f39a017141.jpg" />  <source media="(-webkit-min-device-pixel-ratio: 2),(min--moz-device-pixel-ratio: 2),(min-device-pixel-ratio: 2),(-o-min-device-pixel-ratio: 2/1)" srcset="/fileadmin/_processed_/0/9/csm_torsten_schwede_97068f5677.jpg" />  <source srcset="/fileadmin/_processed_/0/9/csm_torsten_schwede_79bdd077b2.jpg" /> <img src="/fileadmin/_processed_/0/9/csm_torsten_schwede_79bdd077b2.jpg" alt="" /></picture> </div> <h4>Head of Research Group</h4> <h3>Prof. Dr. Torsten Schwede</h3> <a class="color-purple cv-link" href="/research/research-groups/research-groups-a-z/own-content/unit/research-group-torsten-schwede/schwede-cv"> Curriculum Vitae </a> <span class="icon-arrow-right"></span> <div class="description-iframe"> <p> Biozentrum, Room: 08.038 <br /> <a href="+41 61 207 15 81"><span class="icon-phone"></span>+41 61 207 15 81</a> <br /> <span class="icon-mail"></span> <a href="javascript:linkTo_UnCryptMailto(%27qempxs.xsvwxir2wglaihiDyrmfew2gl%27);">torsten.schwede<span class="ts-a"></span>unibas<span class="ts-b"></span>ch</a> </p> </div> <ul class="sociallink horizontal"> <li> <a href="https://twitter.com/TorstenSchwede" title="Twitter" target="_blank" class="twitter" rel="noreferrer">https://twitter.com/TorstenSchwede</a> </li> <li> <a href="https://bsky.app/profile/torstenschwede.bsky.social" title="Bluesky" target="_blank" class="bluesky" rel="noreferrer">https://bsky.app/profile/torstenschwede.bsky.social</a> </li> <li> <a href="https://mstdn.science/@TorstenSchwede" title="Mastodon" target="_blank" class="mastodon" rel="noreferrer">https://mstdn.science/@TorstenSchwede</a> </li> </ul> </div> <ul id="more-navigation"> <li> <h3 class="more no-margin"><a>Contact<span class="icon-plus-png rotate-180-off"></span></a></h3> <div class="more-content"> <div class="inner"> <p> <small> <span> </span> <br /> Biozentrum, Room: 08.038<br /> <a href="tel:+41 61 207 15 81"><span class="icon-phone"></span>+41 61 207 15 81</a> <br /> <span class="icon-mail"></span> <a href="javascript:linkTo_UnCryptMailto(%27qempxs.xsvwxir2wglaihiDyrmfew2gl%27);">torsten.schwede<span class="ts-a"></span>unibas<span class="ts-b"></span>ch</a> </small> </p> <p> <small> <b>Administrative Assistant</b> <br/> Rita Manohar<br> Biozentrum 08.004 <br/> <a href="tel:+41 61 207 22 36"><span class="icon-phone"></span>+41 61 207 22 36</a> <br/> <span class="icon-mail"></span> <a href="javascript:linkTo_UnCryptMailto(%27qempxs.vmxe2qerslevDyrmfew2gl%27);">rita.manohar<span class="ts-a"></span>unibas<span class="ts-b"></span>ch</a> </small> </p> </div> </div> </li> </ul> </div> <div id="research-menu-wrapper"> <div class="submenu-xs"> <div class="submenu-xs-parent submenu-mobile-research" id="researchMenuButton"> Details <span id="subnav-arrow" class="icon-plus-png-small rotate-180-off"></span> </div> </div> <ul id="side-navigation"> <li class="active"> <h4> <a href="/research/research-groups/research-groups-a-z/overview/unit/research-group-torsten-schwede"> Overview <span class="icon-arrow-right"></span> </a> </h4> </li> <li class=""> <h4> <a href="/research/research-groups/research-groups-a-z/group/unit/research-group-torsten-schwede"> Group <span class="icon-arrow-right"></span> </a> </h4> </li> <li class=""> <h4> <a href="/research/research-groups/research-groups-a-z/own-content/unit/research-group-torsten-schwede/schwede-publications"> Publications <span class="icon-arrow-right"></span> </a> <ul> </ul> </h4> </li> <li class=""> <h4> <a href="/research/research-groups/research-groups-a-z/own-content/unit/research-group-torsten-schwede/schwede-projects"> Projects <span class="icon-arrow-right"></span> </a> <ul> </ul> </h4> </li> <li class=""> <h4> <a href="/research/research-groups/research-groups-a-z/own-content/unit/research-group-torsten-schwede/schwede-services-software"> Services & Software <span class="icon-arrow-right"></span> </a> <ul> </ul> </h4> </li> </ul> </div> </div> </div> </section> </aside>  <div id="content" class="col-sm-8 content-area"> <hr class="hidden"> <h2 class="text-hide">Main Content</h2> <section class="section-bgcolor-0 section-default"> <div class="container content-container-bioz"> <div class="tx-x4eresearch"> <div class="container content-area"> <h1>Protein Bioinformatics in 3D: sequence – structure – function</h1> <h3>The function of proteins can be studied at the atomic level using methods for molecular modeling and simulation of their three-dimensional structures.</h3> <p> </p> <div class="medium-image"> <div class="responsive"> <div class="lightbox preview"> <picture>  <source media="(min-width: 550px) and (-webkit-min-device-pixel-ratio: 2),(min--moz-device-pixel-ratio: 2),(min-device-pixel-ratio: 2),(-o-min-device-pixel-ratio: 2/1)" srcset="/fileadmin/_processed_/c/7/csm_schwede_torsten_2018_5026031125.jpg" />  <source media="(min-width: 550px)" srcset="/fileadmin/_processed_/c/7/csm_schwede_torsten_2018_03dc98e80b.jpg" />  <source media="(-webkit-min-device-pixel-ratio: 2),(min--moz-device-pixel-ratio: 2),(min-device-pixel-ratio: 2),(-o-min-device-pixel-ratio: 2/1)" srcset="/fileadmin/_processed_/c/7/csm_schwede_torsten_2018_f2b721ebdd.jpg" />  <source srcset="/fileadmin/_processed_/c/7/csm_schwede_torsten_2018_b3ac71827d.jpg" /> <img src="/fileadmin/_processed_/c/7/csm_schwede_torsten_2018_b3ac71827d.jpg" alt="" /></picture> <p class="description"> <small> Comparison of the homodimeric SWISS-MODEL structure prediction (subunits in red and blue) for the enzyme Cytosolic Malate Dehydrogenase 1 with the experimentally determined structure (grey). </small> <a href="/fileadmin/_processed_/c/7/csm_schwede_torsten_2018_f07112b094.jpg" data-lity data-lity-desc="Comparison of the homodimeric SWISS-MODEL structure prediction (subunits in red and blue) for the enzyme Cytosolic Malate Dehydrogenase 1 with the experimentally determined structure (grey)."> <span class="icon-lightbox"></span> </a> </p> </div> </div> </div> <p>Proteins are the key tools of the cell and are responsible for the most important functions of living organisms. The specific spatial structures of proteins are decisive for their function. Computer simulations allow us to model the properties of three-dimensional protein structures and obtain information about their function at an atomic level of detail. This knowledge helps in basic research on protein function as well as in drug development.</p> <p><strong>Computational Modeling of 3D structures</strong><br> We develop computer programs which allow us to model the structure of proteins that have not previously been elucidated experimentally. We are focusing on comparative protein modeling methods, also known as "homology modeling". By this technique, the structure of an unknown protein is interpolated from structures of known related proteins. Using this approach, reliable predictions can be made for most proteins in typical model organisms.</p> <p><strong>Which mutations cause disease?</strong><br> The possible effects of mutations on the function of a particular protein can often be interpreted with the help of its structure. This knowledge makes it easier to understand hereditary diseases in humans and to interpret the variations observed in the human genome. Conversely, computer models can be used for targeted planning of mutations in proteins in order to investigate their function in the laboratory.</p> <p><strong>Specific interactions with small molecule</strong><br> Many proteins show interactions with small chemical molecules, e.g. with metabolites during metabolism or hormones in signal transmission. Computer simulations allow a better understanding of the receptor's binding specificity. Structure-based drug development involves a targeted search for chemical molecules that specifically occupy a particular binding site.</p> <p><strong>Macromolecular assemblies </strong><br> Cellular processes often depend on interactions between proteins and the formation of macromolecular complexes. Impairments of such interactions can lead to deregulation of pathways resulting in disease states. Detailed insight into such interactions is enabled by studying macromolecular models available with the latest SWISS-MODEL. Our method solely employs amino acid sequences of the interacting proteins as a user input to infer the stoichiometry and the overall structure of the assembly by homology modeling. </p>  <section id="se3522" class="frame section-bgcolor-0 section-default frame-default frame-type-html frame-layout-0"> <div class="container content-container"> <a rel="me" href=https://mstdn.science/@TorstenSchwede> </a> </div> </section> </div> </div> </div> </section> </div>  </div> <div class="container-fluid section-bgcolor-1 full-width-expansion">  <section class="section-bgcolor-1 section-default"> <div class="container content-container-bioz"> <div class="tx-x4eresearch"> <div class="row research-footer-info"> <div class="col-sm-4 research-news"> <h3>News</h3> <div class="news"> <div id="news"> <div class="news-list-view">  <a class="teaser col-md-6" title="Two new SNSF Ambizione Fellows at the Biozentrum" href="/news/detail/two-new-snsf-ambizione-fellows-at-the-biozentrum"> <div class="article articletype-0 topnews" itemscope="itemscope" itemtype="http://schema.org/Article"> <div class="news-img-wrap"> <div class="outer"> <div class="mediaElement mediaElement-image"> <div class="preview"> <picture>  <source media="(min-width: 400px) and (-webkit-min-device-pixel-ratio: 2),(min--moz-device-pixel-ratio: 2),(min-device-pixel-ratio: 2),(-o-min-device-pixel-ratio: 2/1)" srcset="/fileadmin/_processed_/8/a/csm_News_Portraits_AmbizioneFellows_2024_e2df90a403.jpg" /> <source media="(min-width: 300px) and (-webkit-min-device-pixel-ratio: 2),(min--moz-device-pixel-ratio: 2),(min-device-pixel-ratio: 2),(-o-min-device-pixel-ratio: 2/1)" srcset="/fileadmin/_processed_/8/a/csm_News_Portraits_AmbizioneFellows_2024_9304bd90fc.jpg" />  <source media="(min-width: 400px)" srcset="/fileadmin/_processed_/8/a/csm_News_Portraits_AmbizioneFellows_2024_98162908fb.jpg" /> <source media="(min-width: 300px)" srcset="/fileadmin/_processed_/8/a/csm_News_Portraits_AmbizioneFellows_2024_f2bee56364.jpg" />  <source srcset="/fileadmin/_processed_/8/a/csm_News_Portraits_AmbizioneFellows_2024_0b3dbc8268.jpg" /> <img src="/fileadmin/_processed_/8/a/csm_News_Portraits_AmbizioneFellows_2024_0b3dbc8268.jpg" alt="Janani Durairaj and Fengjie Wu have received an SNSF Ambizione Fellowship." /></picture> </div> </div> </div> </div> <div class="content"> <p class="color-purple date-news"> <b> September 16, 2024 </b> </p>  <h3> <span itemprop="headline">Two new SNSF Ambizione Fellows at the Biozentrum</span> </h3> <div itemprop="description"><p>The Swiss National Science Foundation (SNSF) has awarded two young scientists from the Biozentrum at University of Basel a prestigious Ambizione…</p> </div> </div> </div> </a>  <a class="teaser col-md-6" title="Two Biozentrum researchers selected as International Society for Computational Biology Fellow" href="/news/detail/two-biozentrum-researchers-selected-as-international-society-for-computational-biology-fellow"> <div class="article articletype-0" itemscope="itemscope" itemtype="http://schema.org/Article"> <div class="news-img-wrap"> <div class="outer"> <div class="mediaElement mediaElement-image"> <div class="preview"> <picture>  <source media="(min-width: 400px) and (-webkit-min-device-pixel-ratio: 2),(min--moz-device-pixel-ratio: 2),(min-device-pixel-ratio: 2),(-o-min-device-pixel-ratio: 2/1)" srcset="/fileadmin/_processed_/f/5/csm_schwede_zavolan_943c2cd64b.jpg" /> <source media="(min-width: 300px) and (-webkit-min-device-pixel-ratio: 2),(min--moz-device-pixel-ratio: 2),(min-device-pixel-ratio: 2),(-o-min-device-pixel-ratio: 2/1)" srcset="/fileadmin/_processed_/f/5/csm_schwede_zavolan_920b7fd34c.jpg" />  <source media="(min-width: 400px)" srcset="/fileadmin/_processed_/f/5/csm_schwede_zavolan_6cbfa0f7b3.jpg" /> <source media="(min-width: 300px)" srcset="/fileadmin/_processed_/f/5/csm_schwede_zavolan_3b8bcf185d.jpg" />  <source srcset="/fileadmin/_processed_/f/5/csm_schwede_zavolan_1640d3ba53.jpg" /> <img src="/fileadmin/_processed_/f/5/csm_schwede_zavolan_1640d3ba53.jpg" alt="" /></picture> </div> </div> </div> </div> <div class="content"> <p class="color-purple date-news"> <b> March 14, 2024 </b> </p>  <h3> <span itemprop="headline">Two Biozentrum researchers selected as International Society for Computational Biology Fellow</span> </h3> <div itemprop="description"><p>Two professors of the Biozentrum, University of Basel, and at the Swiss Institute of Bioinformatics have now been selected as new fellows of the…</p> </div> </div> </div> </a> </div> </div> </div> </div> <div class="col-sm-4 research-links"> <h3>Related links</h3> <div class="color-purple"> <p><a href="https://www.sib.swiss/torsten-schwede-group" target="_blank" rel="noreferrer">SIB Swiss Institute of Bioinformatics</a></p> <p><a href="http://scicore.unibas.ch/" target="_blank" class="link-external-new-window" data-htmlarea-external="1" rel="noreferrer">sciCORE – center for scientific computing</a></p> </div> </div> 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