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extract</title> <meta name="description" content="Search results for: polyphenolic extract"> <meta name="keywords" content="polyphenolic extract"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="polyphenolic extract"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 2135</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: polyphenolic extract</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2135</span> Study of the Antimicrobial Potential Of a Rich Polyphenolic Extract Obtained from Cytisus scoparius</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lorena%20G.%20Calvo">Lorena G. Calvo</a>, <a href="https://publications.waset.org/abstracts/search?q=Marta%20Lores"> Marta Lores</a>, <a href="https://publications.waset.org/abstracts/search?q=Trinidad%20de%20Miguel"> Trinidad de Miguel</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Natural extracts containing high polyphenolic concentration possess antibacterial and antifungal activity. The present research characterizes a hydro-organic extract with a high polyphenolic content as an antimicrobial candidate. As a result of this composition, the extract showed pronounced bioactivities with potential uses in agricultural, veterinary, pharmaceutical, and cosmetic industries. Polyphenol compounds were extracted by using hydro-organic solvent mixtures from the shrub Cytisus scoparius. The in vitro antimicrobial activity of this extract was evaluated on Gram-positive and Gram-negative bacteria and the fungus Candida albicans. Microbial species investigated, Bacillus cereus, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, are causing agents of several human and animal diseases. The extract showed activity against all tested species. So, it could be used for the development of biocides to control a wide range of pathogenic agents and contribute to the creation of economic and eco-friendly alternatives to antibiotics. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antimicrobial%20properties" title="antimicrobial properties">antimicrobial properties</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidant%20properties" title=" antioxidant properties"> antioxidant properties</a>, <a href="https://publications.waset.org/abstracts/search?q=Cytisus%20scoparius" title=" Cytisus scoparius"> Cytisus scoparius</a>, <a href="https://publications.waset.org/abstracts/search?q=polyphenolic%20extract" title=" polyphenolic extract"> polyphenolic extract</a> </p> <a href="https://publications.waset.org/abstracts/135050/study-of-the-antimicrobial-potential-of-a-rich-polyphenolic-extract-obtained-from-cytisus-scoparius" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/135050.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">146</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2134</span> Rooting Out Breast Cancer by Repressing ER Gene Expression: Correlating Bioactivity of Pomegranate Rind with Chemical Constituents Identified by HPLC-MS/MS</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Alaa%20M.%20M.%20Badr%20Eldin">Alaa M. M. Badr Eldin</a>, <a href="https://publications.waset.org/abstracts/search?q=Marwa%20I.%20Ezzat"> Marwa I. Ezzat</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammed%20S.%20Sedeek"> Mohammed S. Sedeek</a>, <a href="https://publications.waset.org/abstracts/search?q=Manal%20S.%20Afifi"> Manal S. Afifi</a>, <a href="https://publications.waset.org/abstracts/search?q=Omar%20M.%20Sabry"> Omar M. Sabry</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Cytotoxic activity of the total methanol extract against breast cancer cell line MCF-7 was amazing IC50 at 54 ug/ml. 130 polyphenolic compounds were tentatively identified in pomegranate peel (Punica granatum L.) methanol extract using HPLC-MS/MS technique. The antiestrogenic activity of the polyphenolic constituents found in pomegranate extract was confirmed experimentally in-vitro and by the in-silico molecular docking using gallagic acid, ellagic acid, and Punicalagin as these are considered model compounds confirmed in pomegranate peel extract. The methanolic extract was found to suppress ER, TGF-β, and NF-kB in-vitro gene expression strongly, and that was verified by qPCR and Western Blot gel electrophoresis techniques. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=HPLC-MS%2FMS" title="HPLC-MS/MS">HPLC-MS/MS</a>, <a href="https://publications.waset.org/abstracts/search?q=pomegranate" title=" pomegranate"> pomegranate</a>, <a href="https://publications.waset.org/abstracts/search?q=breast%20cancer" title=" breast cancer"> breast cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=ovarian%20cancer" title=" ovarian cancer"> ovarian cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=ER" title=" ER"> ER</a>, <a href="https://publications.waset.org/abstracts/search?q=TGF-%CE%B2" title=" TGF-β"> TGF-β</a>, <a href="https://publications.waset.org/abstracts/search?q=NF-kB" title=" NF-kB"> NF-kB</a> </p> <a href="https://publications.waset.org/abstracts/158003/rooting-out-breast-cancer-by-repressing-er-gene-expression-correlating-bioactivity-of-pomegranate-rind-with-chemical-constituents-identified-by-hplc-msms" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/158003.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">102</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2133</span> Triggering Apoptosis to Uproot Breast Cancer: HPLC-MS/MS Profiling, in-vitro and in-silico Fascinating Results of Polyphenolics in Pomegranate Rind Extract</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Alaa%20M.%20Badr%20Eldin">Alaa M. Badr Eldin</a>, <a href="https://publications.waset.org/abstracts/search?q=Mayar%20M.%20Shahen"> Mayar M. Shahen</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammed%20S.%20Sedeek"> Mohammed S. Sedeek</a>, <a href="https://publications.waset.org/abstracts/search?q=Marwa%20I.%20Ezzat"> Marwa I. Ezzat</a>, <a href="https://publications.waset.org/abstracts/search?q=Sawsan%20M.%20ElSonbaty"> Sawsan M. ElSonbaty</a>, <a href="https://publications.waset.org/abstracts/search?q=Muhammed%20A.%20Saad"> Muhammed A. Saad</a>, <a href="https://publications.waset.org/abstracts/search?q=Manal%20S.%20Afifi"> Manal S. Afifi</a>, <a href="https://publications.waset.org/abstracts/search?q=Omar%20M.%20Sabry"> Omar M. Sabry</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Using HPLC-MS/MS technique, 133 polyphenolic compounds were identified in the methanol extract of pomegranate rind (Punica granatum L.). In-vitro cytotoxic activity against breast cancer cell line MCF-7 was investigated, with an IC50 of 54 ug/ml. In-silico molecular docking using ellagic acid, gallagic acid, and Punicalagin as model compounds identified in pomegranate rind extract confirmed the intriguing anti-estrogenic action of the key polyphenolic components in pomegranate rind extract. Surprisingly, taxol showed low activity compared to pomegranate compounds as ERα antagonist and ERβ agonist. Pomegranate rind extract enhanced apoptosis of breast cancer cells through upregulation of the caspase-3 expression and downregulation of NF-κB transcription factor. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=HPLC-MS%2FMS" title="HPLC-MS/MS">HPLC-MS/MS</a>, <a href="https://publications.waset.org/abstracts/search?q=pomegranate%20rind" title=" pomegranate rind"> pomegranate rind</a>, <a href="https://publications.waset.org/abstracts/search?q=cytotoxicity" title=" cytotoxicity"> cytotoxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=MCF-7" title=" MCF-7"> MCF-7</a>, <a href="https://publications.waset.org/abstracts/search?q=ER" title=" ER"> ER</a>, <a href="https://publications.waset.org/abstracts/search?q=caspase-3" title=" caspase-3"> caspase-3</a>, <a href="https://publications.waset.org/abstracts/search?q=NF-kB" title=" NF-kB"> NF-kB</a> </p> <a href="https://publications.waset.org/abstracts/163413/triggering-apoptosis-to-uproot-breast-cancer-hplc-msms-profiling-in-vitro-and-in-silico-fascinating-results-of-polyphenolics-in-pomegranate-rind-extract" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/163413.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">116</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2132</span> The Effect of Different Concentrations of Extracting Solvent on the Polyphenolic Content and Antioxidant Activity of Gynura procumbens Leaves</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kam%20Wen%20Hang">Kam Wen Hang</a>, <a href="https://publications.waset.org/abstracts/search?q=Tan%20Kee%20Teng"> Tan Kee Teng</a>, <a href="https://publications.waset.org/abstracts/search?q=Huang%20Poh%20Ching"> Huang Poh Ching</a>, <a href="https://publications.waset.org/abstracts/search?q=Chia%20Kai%20Xiang"> Chia Kai Xiang</a>, <a href="https://publications.waset.org/abstracts/search?q=H.%20V.%20Annegowda"> H. V. Annegowda</a>, <a href="https://publications.waset.org/abstracts/search?q=H.%20S.%20Naveen%20Kumar"> H. S. Naveen Kumar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Gynura procumbens (G. procumbens) leaves, commonly known as ‘sambung nyawa’ in Malaysia is a well-known medicinal plant commonly used as folk medicines in controlling blood glucose, cholesterol level as well as treating cancer. These medicinal properties were believed to be related to the polyphenolic content present in G. procumbens extract, therefore optimization of its extraction process is vital to obtain highest possible antioxidant activities. The current study was conducted to investigate the effect of different concentrations of extracting solvent (ethanol) on the amount of polyphenolic content and antioxidant activities of G. procumbens leaf extract. The concentrations of ethanol used were 30-70%, with the temperature and time kept constant at 50°C and 30 minutes, respectively using ultrasound-assisted extraction. The polyphenolic content of these extracts were quantified by Folin-Ciocalteu colorimetric method and results were expressed as milligram gallic acid equivalent (mg GAE)/g. Phosphomolybdenum method and 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assays were used to investigate the antioxidant properties of the extract and the results were expressed as milligram ascorbic acid equivalent (mg AAE)/g and effective concentration (EC50) respectively. Among the three different (30%, 50% and 70%) concentrations of ethanol studied, the 50% ethanolic extract showed total phenolic content of 31.565 ± 0.344 mg GAE/g and total antioxidant activity of 78.839 ± 0.199 mg AAE/g while 30% ethanolic extract showed 29.214 ± 0.645 mg GAE/g and 70.701 ± 1.394 mg AAE/g, respectively. With respect to DPPH radical scavenging assay, 50% ethanolic extract had exhibited slightly lower EC50 (314.3 ± 4.0 μg/ml) values compared to 30% ethanol extract (340.4 ± 5.3 μg/ml). Out of all the tested extracts, 70% ethanolic extract exhibited significantly (p< 0.05) highest total phenolic content (38.000 ± 1.009 mg GAE/g), total antioxidant capacity (95.874 ± 2.422 mg AAE/g) and demonstrated the lowest EC50 in DPPH assay (244.2 ± 5.9 μg/ml). An excellent correlations were drawn between total phenolic content, total antioxidant capacity and DPPH radical scavenging activity (R2 = 0.949 and R2 = 0.978, respectively). It was concluded from this study that, 70% ethanol should be used as the optimal polarity solvent to obtain G. procumbens leaf extract with maximum polyphenolic content with antioxidant properties. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antioxidant%20activity" title="antioxidant activity">antioxidant activity</a>, <a href="https://publications.waset.org/abstracts/search?q=DPPH%20assay" title=" DPPH assay"> DPPH assay</a>, <a href="https://publications.waset.org/abstracts/search?q=Gynura%20procumbens" title=" Gynura procumbens"> Gynura procumbens</a>, <a href="https://publications.waset.org/abstracts/search?q=phenolic%20compounds" title=" phenolic compounds"> phenolic compounds</a> </p> <a href="https://publications.waset.org/abstracts/42004/the-effect-of-different-concentrations-of-extracting-solvent-on-the-polyphenolic-content-and-antioxidant-activity-of-gynura-procumbens-leaves" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/42004.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">411</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2131</span> The Role of Polyphenolic Compounds in the Alpha Amylase and Alpha Glucosidase Inhibitory Potentials of Extracts from the Leaves of Acalypha godseffiana from Eastern Nigeria: An in-vitro Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=A.%20K.%20Asekunowo">A. K. Asekunowo</a>, <a href="https://publications.waset.org/abstracts/search?q=A%20O.%20T.%20Asafa"> A O. T. Asafa</a>, <a href="https://publications.waset.org/abstracts/search?q=O.%20O.%20Okoh"> O. O. Okoh</a>, <a href="https://publications.waset.org/abstracts/search?q=O.%20T.%20Asekun"> O. T. Asekun</a>, <a href="https://publications.waset.org/abstracts/search?q=O.%20B.%20Familoni"> O. B. Familoni</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Acalypha godseffiana is an important plant used both as an ornamental and herbs; its leaves are employed in management of diseases such as diabetics in Eastern Nigeria. Aim: The correlations of the polyphenolic compounds in the hypoglycemic potential of different extracts of leaves of A. godseffiana and their safety profile on cell lines were investigated. Materials and Methods: The phytochemical compositions and antioxidants potentials were determined using adopted methods. An in vitro approach was employed in determining the hypoglycemic potentials of the extracts on α-amylase and α-glucosidase. The Line weaver-Burke plot was used to evaluate the mechanisms of Inhibition mechanisms of the enzymes. Results and Conclusions: Antioxidants results revealed that total antioxidant capacity (TAC) of the acetone extract (IC50: 0.34 mg/mL) showed better activity compared to the standards (silymarine 0.52 mg/mL; gallic acid 0.51 mg/mL). In-vitro hypoglycemic activity of the extracts confirmed that acetone extract demonstrated strong and mild inhibitory potential against α-amylase and α-glucosidase respectively. The observed activity was concentration-dependent with IC50 values of 2.33 and 0.13 mg/mL. The observed hypoglycemic and anti-oxidant potentials of acetone extract A. godseffiana correlate to its high polyphenolic contents which include phenols (133.20 mg gallic acid g-1), flavonoid (350.60 mg quercetin g-1) and tannins (264.67 mg catechin g-1). The mechanisms of action exhibited by acetone extract of A. godseffiana were mixed non-competitive and uncompetitive; which can be attributed to its inhibitory properties on α-amylase and α-glucosidase respectively. This effect would cause reduction in the rate at which starch hydrolyse, boost palliated glucose levels; hence, making acetone extract of A. godseffiana a potential anti-hypoglycemic alternative. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Acalypha%20godeseffiana" title="Acalypha godeseffiana">Acalypha godeseffiana</a>, <a href="https://publications.waset.org/abstracts/search?q=acetone%20extract" title=" acetone extract"> acetone extract</a>, <a href="https://publications.waset.org/abstracts/search?q=anti-hypoglycemia" title=" anti-hypoglycemia"> anti-hypoglycemia</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidant" title=" antioxidant"> antioxidant</a>, <a href="https://publications.waset.org/abstracts/search?q=phytochemicals" title=" phytochemicals"> phytochemicals</a> </p> <a href="https://publications.waset.org/abstracts/61511/the-role-of-polyphenolic-compounds-in-the-alpha-amylase-and-alpha-glucosidase-inhibitory-potentials-of-extracts-from-the-leaves-of-acalypha-godseffiana-from-eastern-nigeria-an-in-vitro-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/61511.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">262</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2130</span> Analysis of Tannins from Padus asiatica</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Telmen%20Dashdondov">Telmen Dashdondov</a>, <a href="https://publications.waset.org/abstracts/search?q=Selenge%20Erdenechimeg"> Selenge Erdenechimeg</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Padus asiatica contains large quantities of polyphenolic compounds, and it is one of the most consumed fruits throughout the country. These compounds have the biological activity of the fruit and have long been used in traditional Mongolian medicine for diarrhea, coughs, pneumonia, and gastritis. In this study, we studied the solvents that can be used to make extracts from dried raw fruits; in order to determine the amount of tannin in Padus asiatica, we selected three solvents: distilled water, 20% ethanol, and 40% ethanol, and determined the amount of tannin. As a result, the amount of extract (distilled water) was 11.8%, the amount of extract (20% ethanol) was 15.7%, and the amount of extract (40% ethanol) was 8.2%. Therefore, it was found that tannins are extracted better in 20% ethanol solution. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Padus%20asiatica" title="Padus asiatica">Padus asiatica</a>, <a href="https://publications.waset.org/abstracts/search?q=tannin" title=" tannin"> tannin</a>, <a href="https://publications.waset.org/abstracts/search?q=diarrhea" title=" diarrhea"> diarrhea</a>, <a href="https://publications.waset.org/abstracts/search?q=Mongolian%20medicinal%20plant" title=" Mongolian medicinal plant"> Mongolian medicinal plant</a> </p> <a href="https://publications.waset.org/abstracts/133732/analysis-of-tannins-from-padus-asiatica" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/133732.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">162</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2129</span> Antibacterial and Antioxidant Properties of Total Phenolics from Waste Orange Peels</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Kanika%20Kalra">Kanika Kalra</a>, <a href="https://publications.waset.org/abstracts/search?q=Harmeet%20Kaur"> Harmeet Kaur</a>, <a href="https://publications.waset.org/abstracts/search?q=Dinesh%20Goyal"> Dinesh Goyal</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Total phenolics were extracted from waste orange peels by solvent extraction and alkali hydrolysis method. The most efficient solvents for extracting phenolic compounds from waste biomass were methanol (60%) > dimethyl sulfoxide > ethanol (60%) > distilled water. The extraction yields were significantly impacted by solvents (ethanol, methanol, and dimethyl sulfoxide) due to varying polarity and concentrations. Extraction of phenolics using 60% methanol yielded the highest phenolics (in terms of gallic acid equivalent (GAE) per gram of biomass) in orange peels. Alkali hydrolyzed extract from orange peels contained 7.58±0.33 mg GAE g⁻¹. By using the solvent extraction technique, it was observed that 60% methanol is comparatively the best-suited solvent for extracting polyphenolic compounds and gave the maximum yield of 4.68 ± 0.47 mg GAE g⁻¹ in orange peel extracts. DPPH radical scavenging activity and reducing the power of orange peel extract were checked, where 60% methanolic extract showed the highest antioxidant activity, 85.50±0.009% for DPPH, and dimethyl sulfoxide (DMSO) extract gave the highest yield of 1.75±0.01% for reducing power ability of the orange peels extract. Characterization of the polyphenolic compounds was done by using Fourier transformation infrared (FTIR) spectroscopy. Solvent and alkali hydrolysed extracts were evaluated for antibacterial activity using the agar well diffusion method against Gram-positive Bacillus subtilis MTCC441 and Gram-negative Escherichia coli MTCC729. Methanolic extract at 300µl concentration showed an inhibition zone of around 16.33±0.47 mm against Bacillus subtilis, whereas, for Escherichia coli, it was comparatively less. Broth-based turbidimetric assay revealed the antibacterial effect of different volumes of orange peel extracts against both organisms. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=orange%20peels" title="orange peels">orange peels</a>, <a href="https://publications.waset.org/abstracts/search?q=total%20phenolic%20content" title=" total phenolic content"> total phenolic content</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidant" title=" antioxidant"> antioxidant</a>, <a href="https://publications.waset.org/abstracts/search?q=antibacterial" title=" antibacterial"> antibacterial</a> </p> <a href="https://publications.waset.org/abstracts/177083/antibacterial-and-antioxidant-properties-of-total-phenolics-from-waste-orange-peels" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/177083.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">73</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2128</span> Gossypol Extraction from Cotton Seed and Evaluation of Cotton Seed and Boll-cotton-pol Extract on Treatment of Cutaneous Leishmaniasis Resistant to Drugs</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=M.%20Mirmohammadi">M. Mirmohammadi</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Taghdisi"> S. Taghdisi</a>, <a href="https://publications.waset.org/abstracts/search?q=F.%20Anali"> F. Anali</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Gossypol is a yellow anti-nutritional compound found in the cotton plant. This substance exists in the cottonseed and other parts of the cotton plant, such as bark, leaves, and stems. Chemically, gossypol is a very active polyphenolic aldehyde compound, and due to this polyphenolic structure, it has antioxidant and therapeutic properties. On the other hand, this compound, especially in free form, has many toxic effects, that its excessive consumption can be very dangerous for humans and animals. In this study, gossypol was extracted as a derivative compound of gossypol acetic acid from cottonseed using the n-hexane solvent with an efficiency of 0.84 ± 0.04, which compared to the Gossypol extracted from cottonseed oil with the same method (cold press) showed a significant difference with its efficiency of 1.14 ± 0.06. Therefore, it can be suggested to use cottonseed oil to extract this valuable compound. In the other part of this research, cottonseed extracts and cotton bolls extracts were obtained by two methods of soaking and Soxhlet with hydroalcoholic solvent taken with a ratio of (25:75), then by using extracts and corn starch powder, four herbal medicine code was created and after receiving the code of ethics (IR.SSU.REC.1398.136) the therapeutic effect of each one on the Cutaneous leishmaniasis resistant to drugs (caused by the leishmaniasis parasite) was investigated in real patients and its results was compared with the common drug glucantime (local ampoule) (n = 36). Statistical studies showed that the use of herbal medicines prepared with cottonseed extract and cotton bolls extract has a significant positive effect on the treatment of the disease’s wounds (p-value > 0.05) compared to the control group (only ethanol). Also, by comparing the average diameter of the wounds after a two-month treatment period, no significant difference was found between the use of ointment containing extracts and local glucantime ampoules (p-value < 0.05). Bolls extract extracted with the Soxhlet method showed the best therapeutic effects, although there was no significant difference between them (p-value < 0.05). Therefore, there is acceptable reliability to recommend this medicine for the treatment of Cutaneous leishmaniasis resistant to drugs without the side effects of the chemical drug glucantime and the pain of injecting the ampoule. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cottonseed%20oil" title="cottonseed oil">cottonseed oil</a>, <a href="https://publications.waset.org/abstracts/search?q=gossypol" title=" gossypol"> gossypol</a>, <a href="https://publications.waset.org/abstracts/search?q=cotton%20boll" title=" cotton boll"> cotton boll</a>, <a href="https://publications.waset.org/abstracts/search?q=cutaneous%20leishmaniasis" title=" cutaneous leishmaniasis"> cutaneous leishmaniasis</a> </p> <a href="https://publications.waset.org/abstracts/170552/gossypol-extraction-from-cotton-seed-and-evaluation-of-cotton-seed-and-boll-cotton-pol-extract-on-treatment-of-cutaneous-leishmaniasis-resistant-to-drugs" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/170552.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">95</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2127</span> Antioxidative Potential of Aqueous Extract of Ocimum americanum L. Leaves: An in vitro and in vivo Evaluation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bukola%20Tola%20Aluko">Bukola Tola Aluko</a>, <a href="https://publications.waset.org/abstracts/search?q=Omotade%20Ibidun%20Oloyede"> Omotade Ibidun Oloyede</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Ocimum americanum L. (Lamiaceae) is an annual herb that is native to tropical Africa. The in vitro and in vivo antioxidant activity of its aqueous extract was carefully investigated by assessing the DPPH radical scavenging activity, ABTS radical scavenging activity and hydrogen peroxide radical scavenging activity. The reducing power, total phenol, total flavonoids and flavonols content of the extract were also evaluated. The data obtained revealed that the extract is rich in polyphenolic compounds and scavenged the radicals in a concentration-dependent manner. This was done in comparison with the standard antioxidants such as BHT and Vitamin C. Also, the induction of oxidative damage with paracetamol (2000 mg/kg) resulted in the elevation of lipid peroxides and significant (P < 0.05) decrease in activities of superoxide dismutase, glutathione peroxidase, glutathione reductase and catalase in the liver and kidney of rats. However, the pretreatment of rats with aqueous extract of O. americanum leaves (200 and 400 mg/kg), and silymarin (100 mg/kg) caused a significant (P < 0.05) reduction in the values of lipid peroxides and restored the levels of antioxidant parameters in these organs. These findings suggest that the leaves of O. americanum have potent antioxidant properties which may be responsible for its acclaimed folkloric uses. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antioxidants" title="antioxidants">antioxidants</a>, <a href="https://publications.waset.org/abstracts/search?q=free%20radicals" title=" free radicals"> free radicals</a>, <a href="https://publications.waset.org/abstracts/search?q=ocimum%20%20americanum" title=" ocimum americanum"> ocimum americanum</a>, <a href="https://publications.waset.org/abstracts/search?q=scavenging%20activity" title=" scavenging activity"> scavenging activity</a> </p> <a href="https://publications.waset.org/abstracts/22578/antioxidative-potential-of-aqueous-extract-of-ocimum-americanum-l-leaves-an-in-vitro-and-in-vivo-evaluation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/22578.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">334</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2126</span> Ultrasound/Microwave Assisted Extraction Recovery and Identification of Bioactive Compounds (Polyphenols) from Tarbush (Fluorensia cernua)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Marisol%20Rodriguez-Duarte">Marisol Rodriguez-Duarte</a>, <a href="https://publications.waset.org/abstracts/search?q=Aide%20Saenz-Galindo"> Aide Saenz-Galindo</a>, <a href="https://publications.waset.org/abstracts/search?q=Carolina%20Flores-Gallegos"> Carolina Flores-Gallegos</a>, <a href="https://publications.waset.org/abstracts/search?q=Raul%20Rodriguez-Herrera"> Raul Rodriguez-Herrera</a>, <a href="https://publications.waset.org/abstracts/search?q=Juan%20Ascacio-Valdes"> Juan Ascacio-Valdes</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The plant known as tarbush (Fluorensia cernua) is a plant originating in northern Mexico, mainly in the states of Coahuila, Durango, San Luis Potosí, Zacatecas and Chihuahua. It is a branched shrub that belongs to the family Asteraceae, has oval leaves of 6 to 11 cm in length and also has small yellow flowers. In Mexico, the tarbush is a very appreciated plant because it has been used as a traditional medicinal agent, for the treatment of gastrointestinal diseases, skin infections and as a healing agent. This plant has been used mainly as an infusion. Due to its traditional use, the content and type of phytochemicals present in the plant are currently unknown and are responsible for its biological properties, so its recovery and identification is very important because the compounds that it contains have relevant applications in the field of food, pharmaceuticals and medicine. The objective of this work was to determine the best extraction condition of phytochemical compounds (mainly polyphenolic compounds) from the leaf using ultrasound/microwave assisted extraction (U/M-AE). To reach the objective, U/M-AE extractions were performed evaluating three mass/volume ratios (1:8, 1:12, 1:16), three ethanol/water solvent concentrations (0%, 30% and 70%), ultrasound extraction time of 20 min and 5 min at 70°C of microwave treatment. All experiments were performed using a fractional factorial experimental design. Once the best extraction condition was defined, the compounds were recovered by liquid column chromatography using Amberlite XAD-16, the polyphenolic fraction was recovered with ethanol and then evaporated. The recovered polyphenolic compounds were quantified by spectrophotometric techniques and identified by HPLC/ESI/MS. The results obtained showed that the best extraction condition of the compounds was using a mass/volume ratio of 1:8 and solvent ethanol/water concentration of 70%. The concentration obtained from polyphenolic compounds using this condition was 22.74 mg/g and finally, 16 compounds of polyphenolic origin were identified. The results obtained in this work allow us to postulate the Mexican plant known as tarbush as a relevant source of bioactive polyphenolic compounds of food, pharmaceutical and medicinal interest. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=U%2FM-AE" title="U/M-AE">U/M-AE</a>, <a href="https://publications.waset.org/abstracts/search?q=tarbush" title=" tarbush"> tarbush</a>, <a href="https://publications.waset.org/abstracts/search?q=polyphenols" title=" polyphenols"> polyphenols</a>, <a href="https://publications.waset.org/abstracts/search?q=identification" title=" identification"> identification</a> </p> <a href="https://publications.waset.org/abstracts/102851/ultrasoundmicrowave-assisted-extraction-recovery-and-identification-of-bioactive-compounds-polyphenols-from-tarbush-fluorensia-cernua" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/102851.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">163</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2125</span> Preventing Neurodegenerative Diseases by Stabilization of Superoxide Dismutase by Natural Polyphenolic Compounds</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Danish%20Idrees">Danish Idrees</a>, <a href="https://publications.waset.org/abstracts/search?q=Vijay%20Kumar"> Vijay Kumar</a>, <a href="https://publications.waset.org/abstracts/search?q=Samudrala%20Gourinath"> Samudrala Gourinath</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease caused by misfolding and aggregation of Cu, Zn superoxide dismutase (SOD1). The use of small molecules has been shown to stabilize the SOD1 dimer and preventing its dissociation and aggregation. In this study, we employed molecular docking, molecular dynamics simulation and surface plasmon resonance (SPR) to study the interactions between SOD1 and natural polyphenolic compounds. In order to explore the noncovalent interaction between SOD1 and natural polyphenolic compounds, molecular docking and molecular dynamic (MD) simulations were employed to gain insights into the binding modes and free energies of SOD1-polyphenolic compounds. MM/PBSA methods were used to calculate free energies from obtained MD trajectories. The compounds, Hesperidin, Ergosterol, and Rutin showed the excellent binding affinity in micromolar range with SOD1. Ergosterol and Hesperidin have the strongest binding affinity to SOD1 and was subjected to further characterization. Biophysical experiments using Circular Dichroism and Thioflavin T fluorescence spectroscopy results show that the binding of these two compounds can stabilize SOD1 dimer and inhibit the aggregation of SOD1. Molecular simulation results also suggest that these compounds reduce the dissociation of SOD1 dimers through direct interaction with the dimer interface. This study will be helpful to develop other drug-like molecules which may have the effect to reduce the aggregation of SOD1. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=amyotrophic%20lateral%20sclerosis" title="amyotrophic lateral sclerosis">amyotrophic lateral sclerosis</a>, <a href="https://publications.waset.org/abstracts/search?q=molecular%20dynamics%20simulation" title=" molecular dynamics simulation"> molecular dynamics simulation</a>, <a href="https://publications.waset.org/abstracts/search?q=surface%20plasmon%20resonance" title=" surface plasmon resonance"> surface plasmon resonance</a>, <a href="https://publications.waset.org/abstracts/search?q=superoxide%20dismutase" title=" superoxide dismutase"> superoxide dismutase</a> </p> <a href="https://publications.waset.org/abstracts/98839/preventing-neurodegenerative-diseases-by-stabilization-of-superoxide-dismutase-by-natural-polyphenolic-compounds" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/98839.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">138</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2124</span> Phytochemical Screening and Toxicological Studies of Aqueous Stem Bark Extract of Boswellia papyrifera (DEL) in Albino Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Y.%20Abdulmumin">Y. Abdulmumin</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20I.%20Matazu"> K. I. Matazu</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20M.%20Wudil"> A. M. Wudil</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20J.%20Alhassan"> A. J. Alhassan</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20A.%20Imam"> A. A. Imam</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Phytochemical analysis of Boswellia papryfera confirms the presence of various phytochemicals such as alkaloids, flavonoids, tannins, saponins and cardiac glycosides in its aqueous stem bark extract at different concentration, with tannins being the highest (0.611 ± 0.002 g %). Acute toxicity test (LD50,oral, rat) of the extract showed no mortality at up to 5000 mg/kg and the animals were found active and healthy. The extract was declared as practically non-toxic, this suggest the safety of the extract in traditional medicine. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=acute%20toxicity" title="acute toxicity">acute toxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=aqueous%20extract" title=" aqueous extract"> aqueous extract</a>, <a href="https://publications.waset.org/abstracts/search?q=boswellia%20papryfera" title=" boswellia papryfera"> boswellia papryfera</a>, <a href="https://publications.waset.org/abstracts/search?q=phytochemicals" title=" phytochemicals"> phytochemicals</a>, <a href="https://publications.waset.org/abstracts/search?q=stem%20bark%20extract" title=" stem bark extract"> stem bark extract</a> </p> <a href="https://publications.waset.org/abstracts/34096/phytochemical-screening-and-toxicological-studies-of-aqueous-stem-bark-extract-of-boswellia-papyrifera-del-in-albino-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/34096.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">427</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2123</span> The Antioxidant Gel Mask Supplies Of Bitter Melon's Extract ( Momordica charantia Linn.)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=N.%20S.%20Risqina">N. S. Risqina</a>, <a href="https://publications.waset.org/abstracts/search?q=G.%20Edijanti"> G. Edijanti</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20S.%20Nurita"> P. S. Nurita</a>, <a href="https://publications.waset.org/abstracts/search?q=L.%20Endang"> L. Endang</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20A.%20Siti"> R. A. Siti</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Tri"> R. Tri </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Skin is an important and vital organs and also as a mirror of health and life. Facial skin care is one of the main emphasis to get the beautiful, healthy, and fresh skin. Potentially antioxidant phenolic compounds shows, antimutagen, antitumor, anti-inflammatory, and anti-cancer. Flavonoids are a group of polyphenolic compounds that have the nature of free radicals, inhibiting the oxidative and hydrolytic enzymes as well as anti-inflammatory. Bitter melon (Momordica charantia Linn) is a plant that contains flavonoids, and phenolic antioxidant activity. Bitter melon has strong antioxidant activity that can counteract the free radicals.These compounds can prevent free radicals that cause premature aging. Gel masks including depth cleansing is the cosmetics which work in depth and could raise the dead skin cells. Measurement of antioxidant activity of the extract and gel mask is done by using the immersion method of DPPH. IC50 value of ethanol extract of bitter melon fruit of 287.932 ppm. The preparation of gel mask bitter melon fruit extract, necessary to test the effectiveness of antioxidants using DPPH method is done by measuring the inhibition of DPPH and using UV spectrophotometer at the wavelength of maximum DPPH solution. Tests conducted at the beginning and end of the evaluation (day 0 and day 28). The purpose of this study is to determine the antioxidant activity of the bitter melon's extract and to determine the antioxidant activity of ethanol extract gel mask pare in varying concentrations, ie 1xIC100 (0.295%), 2xIC100 (0.590%) and 4xIC100 (1.180%). Evaluation of physical properties of the preparation on (Day-0,7,14,21, and 28) and evaluation of antioxidant activity (day 0 and 28). Data were analyzed using One Way ANOVA to determine differences in the physical properties of each formula. The statistical results showed that differences in the formula and storage time affects the adhesion, dispersive power, dry time and pH it is shown on a significant value of p <0.05, but longer storage does not affect the pH because the significance value p> 0,05. The antioxidant test showed that there are differences in antioxidant activity in all formulas. Measurement of antioxidant activity of bitter melon fruit extract gel mask on day 0 with a concentration of 0.295%, 0.590%, and 1.180%, respectively, are 124,209.277 ppm, ppm 83819.223 and 47323.592 ppm, whereas day 28 consecutive 130 411, 495 ppm, and 53239.806 95561.645 ppm ppm. The Conclusions drawn that there are antioxidant activity in preparation gel mask of bitter melon fruit extract. The antioxidant activity of bitter melon fruit extract gel mask on the day 0 with a concentration of 0.295%, 0.590%, and 1.180%, respectively, are 124,209.277 ppm, ppm 83819.223 and 47323.592 ppm, whereas on day 28 of antioxidant activity gel mask bitter melon fruit extract with a concentration of 0.295%, 0.590%, and 1.180% in succession, namely: 130,411.495 ppm, ppm 95561.645 and 53239.806 ppm. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antioxdant" title="antioxdant">antioxdant</a>, <a href="https://publications.waset.org/abstracts/search?q=bitter%20melon" title=" bitter melon"> bitter melon</a>, <a href="https://publications.waset.org/abstracts/search?q=gel%20mask" title=" gel mask"> gel mask</a>, <a href="https://publications.waset.org/abstracts/search?q=IC50" title=" IC50"> IC50</a> </p> <a href="https://publications.waset.org/abstracts/32963/the-antioxidant-gel-mask-supplies-of-bitter-melons-extract-momordica-charantia-linn" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/32963.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">470</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2122</span> Interaction of Vegetable Fillers with Polyethylene Matrix in Biocomposites</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=P.%20V.%20Pantyukhov">P. V. Pantyukhov</a>, <a href="https://publications.waset.org/abstracts/search?q=T.%20V.%20Monakhova"> T. V. Monakhova</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20A.%20Popov"> A. A. Popov</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The paper studies the diffusion of low molecular weight components from vegetable fillers into polyethylene matrix during the preparation of biocomposites. In order to identify the diffusible substances a model experiment used where the hexadecane acted as a model of polyethylene. It was determined that polyphenolic compounds and chlorophyll penetrate from vegetable fillers to hexadecane to the maximum extent. There was found a correlation between the amount of polyphenolic compounds diffusible from the fillers to hexadecane and thermal oxidation kinetics of real biocomposites based on polyethylene and vegetable fillers. Thus, it has been assumed the diffusion of polyphenols and chlorophyll from vegetable fillers into polyethylene matrix during the preparation of biocomposites. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=biocomposite" title="biocomposite">biocomposite</a>, <a href="https://publications.waset.org/abstracts/search?q=composite" title=" composite"> composite</a>, <a href="https://publications.waset.org/abstracts/search?q=diffusion" title=" diffusion"> diffusion</a>, <a href="https://publications.waset.org/abstracts/search?q=polyethylene" title=" polyethylene"> polyethylene</a>, <a href="https://publications.waset.org/abstracts/search?q=vegetable%20filler" title=" vegetable filler"> vegetable filler</a> </p> <a href="https://publications.waset.org/abstracts/19606/interaction-of-vegetable-fillers-with-polyethylene-matrix-in-biocomposites" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/19606.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">446</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2121</span> Therapeutic Effect of Cichorium Intybus Aerial Parts Extract against Oxidative Stress and Nephropathy Induced by Streptozotocin in Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Josline%20Salib">Josline Salib</a>, <a href="https://publications.waset.org/abstracts/search?q=Sayed%20El-Toumy"> Sayed El-Toumy</a>, <a href="https://publications.waset.org/abstracts/search?q=Abeer%20Salama"> Abeer Salama</a>, <a href="https://publications.waset.org/abstracts/search?q=Enayat%20Omara"> Enayat Omara</a>, <a href="https://publications.waset.org/abstracts/search?q=Emad%20Hassan"> Emad Hassan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Diabetic nephropathy is an important cause of morbidity and mortality and is now among the most common causes of end-stage renal failure (ESRF) in developed countries. Thus, the aim of the present study was to investigate the phenolic compounds content of Cichorium intybus aerial parts extracts as well as the therapeutic effects on diabetic nephropathy, oxidative stress, and anti-inflammatory by characterizing biochemical, histopathological changes and immunohistochemistry in an experimental diabetic rat model as compared with Amaryl. Ten known compounds of flavonoids, coumarins and phenolic acid derivatives were isolated from the C. intybus aqueous methanolic extract. Structures of the isolated compounds were established by chromatography, UV and 1D⁄2D 1H⁄ 13C spectroscopy. The aqueous methanol extract of C. intybus aerial parts was administered to Streptozotocin diabetes rats at doses (100 and 200 mg/kg) for 21 days. After treatment, blood glucose, serum insulin, urea, creatinine, and TNF-α were evaluated. Enzymatic scavengers including catalase (CAT), glutathione (GSH), malondialdehyde (MDA) and nitric oxide (NO) were determined to evaluate the oxidative status in the renal tissue. Diabetic rats treated with C. intybus extract showed a dose-dependent reduction of fasting blood glucose and kidney antioxidant status in comparison to the diabetic control group. The extract was able to enhance the antioxidant defenses of the kidney by increasing the reduced GSH and CAT content and decreasing MDA content in addition to significantly decreasing kidney nitric oxide content compared to diabetic control rats. Furthermore, the histopathological findings in C. intybus extract administered rats were observed at markedly lesser extent than the diabetic control group. Also, inducible nitric oxide synthase (iNOS) levels were decreased significantly after the administration of high-dose C. intybus extract in diabetic rats. Showing significant antihyperglycemic and antioxidant properties of C. intybus aerial parts extract, which is attributed to its polyphenolic content, may offer a potential source for the treatment of diabetes. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antioxidant%20activity" title="antioxidant activity">antioxidant activity</a>, <a href="https://publications.waset.org/abstracts/search?q=anti-diabetic%20nephropathy" title=" anti-diabetic nephropathy"> anti-diabetic nephropathy</a>, <a href="https://publications.waset.org/abstracts/search?q=cichorium%20intybus%20aerial%20parts" title=" cichorium intybus aerial parts"> cichorium intybus aerial parts</a>, <a href="https://publications.waset.org/abstracts/search?q=phenolic%20compounds" title=" phenolic compounds"> phenolic compounds</a> </p> <a href="https://publications.waset.org/abstracts/115689/therapeutic-effect-of-cichorium-intybus-aerial-parts-extract-against-oxidative-stress-and-nephropathy-induced-by-streptozotocin-in-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/115689.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">120</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2120</span> Exploring Polypnenolics Content and Antioxidant Activity of R. damascena Dry Extract by Spectroscopic and Chromatographic Techniques</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Daniela%20Nedeltcheva-Antonova">Daniela Nedeltcheva-Antonova</a>, <a href="https://publications.waset.org/abstracts/search?q=Kamelia%20Getchovska"> Kamelia Getchovska</a>, <a href="https://publications.waset.org/abstracts/search?q=Vera%20Deneva"> Vera Deneva</a>, <a href="https://publications.waset.org/abstracts/search?q=Stanislav%20Bozhanov"> Stanislav Bozhanov</a>, <a href="https://publications.waset.org/abstracts/search?q=Liudmil%20Antonov"> Liudmil Antonov</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Rosa damascena Mill. (Damask rose) is one of the most important plants belonging to the Rosaceae family, with a long historical use in traditional medicine and as a valuable oil-bearing plant. Many pharmacological effects have been reported from this plant, including anti-inflammatory, hypnotic, analgesic, anticonvulsant, anti-depressant, antianxiety, antitussive, antidiabetic, relaxant effects on tracheal chains, laxative, prokinetic and hepatoprotective activities. Pharmacological studies have shown that the various health effects of R. damascena flowers can mainly be attributed to its large amount of polyphenolic components. Phenolics possess a wide range of pharmacological activities, such as antioxidants, free-radical scavengers, anticancer, anti-inflammatory, antimutagenic, and antidepressant, with flavonoids being the most numerous group of natural polyphenolic compounds. According to the technological process in the production of rose concrete (solvent extraction with non-polar solvents of fresh rose flowers), it can be assumed that the resulting plant residue would be as rich of polyphenolics, as the plant itself, and could be used for the development of novel products with promising health-promoting effect. Therefore, an optimisation of the extraction procedure of the by-product from the rose concrete production was carried out. An assay of the extracts in respect of their total polyphenols and total flavonoids content was performed. HPLC analysis of quercetin and kaempferol, the two main flavonoids found in R. damascena, was also carried out. The preliminary results have shown that the flavonoid content in the rose extracts is comparable to that of the green tea or Gingko biloba, and they could be used for the development of various products (food supplements, natural cosmetics and phyto-pharmaceutical formulation, etc.). The fact that they are derived from the by-product of industrial plant processing could add the marketing value of the final products in addition to the well-known reputation of the products obtained from Bulgarian roses (R. damascena Mill.). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=gas%20chromatography-mass-spectromrtry" title="gas chromatography-mass-spectromrtry">gas chromatography-mass-spectromrtry</a>, <a href="https://publications.waset.org/abstracts/search?q=dry%20extract" title=" dry extract"> dry extract</a>, <a href="https://publications.waset.org/abstracts/search?q=flavonoids" title=" flavonoids"> flavonoids</a>, <a href="https://publications.waset.org/abstracts/search?q=Rosa%20damascena%20Mill" title=" Rosa damascena Mill"> Rosa damascena Mill</a> </p> <a href="https://publications.waset.org/abstracts/115745/exploring-polypnenolics-content-and-antioxidant-activity-of-r-damascena-dry-extract-by-spectroscopic-and-chromatographic-techniques" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/115745.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">152</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2119</span> The Effect of Olea europea L. Extract on Doxorubicin-Induced Cardiotoxicity</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jessica%20Maiuolo">Jessica Maiuolo</a>, <a href="https://publications.waset.org/abstracts/search?q=Irene%20Bava"> Irene Bava</a>, <a href="https://publications.waset.org/abstracts/search?q=Micaela%20Gliozzi"> Micaela Gliozzi</a>, <a href="https://publications.waset.org/abstracts/search?q=Vincenzo%20Mollace"> Vincenzo Mollace</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Doxorubicin is an anthracycline that is commonly used as a chemotherapy drug due to its cytotoxic effects. The clinical use of doxorubicin is limited due to its known cardiotoxic effects. Polyphenols have a wide range of beneficial properties, and particular importance is given to Oleuropein, one of the main polyphenolic compounds of olive oil. The biological mechanisms involved and the role of the endoplasmic reticulum were examined. Olive oil extract and Oleuropein were able to decrease the damage induced by exposure to doxorubicin. In particular, this natural compound was found to reduce cell mortality and oxidative damage, increase lipid content, and decrease the concentration of calcium ions that escaped from the endoplasmic reticulum. In addition, the direct involvement of this cellular organelle was demonstrated by silencing the ATF6 arm of the Unfolded Protein Response, which was activated after treatment with doxorubicin. The protection afforded by pre-treatment with the natural compound of interest, following the early damage induced by DOXO, provided valuable information regarding the potential use of these substances along with chemotherapy treatment. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Olea%20europea%20L." title="Olea europea L.">Olea europea L.</a>, <a href="https://publications.waset.org/abstracts/search?q=oleuropein" title=" oleuropein"> oleuropein</a>, <a href="https://publications.waset.org/abstracts/search?q=doxorubicin" title=" doxorubicin"> doxorubicin</a>, <a href="https://publications.waset.org/abstracts/search?q=endoplasmic%20reticulum" title=" endoplasmic reticulum"> endoplasmic reticulum</a>, <a href="https://publications.waset.org/abstracts/search?q=nutraceutical%20support" title=" nutraceutical support"> nutraceutical support</a> </p> <a href="https://publications.waset.org/abstracts/156866/the-effect-of-olea-europea-l-extract-on-doxorubicin-induced-cardiotoxicity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/156866.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">110</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2118</span> Free Raducal Scavenging Activity of Fractionated Extract and Structural Elucidation of Isolated Compounds from Hydrocotyl Bonariensis Comm. Ex Lam Leaves</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Emmanuel%20O%20Ajani">Emmanuel O Ajani</a>, <a href="https://publications.waset.org/abstracts/search?q=Sabiu%20S"> Sabiu S</a>, <a href="https://publications.waset.org/abstracts/search?q=Mariam%20Zakari"> Mariam Zakari</a>, <a href="https://publications.waset.org/abstracts/search?q=Fisayo%20A%20Bamisaye"> Fisayo A Bamisaye </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Hydrocotyl bonariensis is a plant which anticataractogenic potentials have been reported. In the present study an attempt was made to evaluate the in vitro antioxidant activity of the fractionates of the leaves extract and also characterize some of its chemical constituents. DPPH, H₂O₂, OH and NO free radical scavenging, metal chelating and reducing power activity was used to evaluate the antioxidant activity of the crude extract fractionates. Fresh leaves of Hydrocotyl bonariensis leaves were extracted in 70% methanol. The extract was partitioned with different solvent system of increasing polarity (n-hexane, chloroform, ethyl acetate methanol and water). Compounds were isolated from the aqueous practitionate using accelerated gradient chromatography, vacuum liquid chromatography, preparative TLC and conventional column chromatography. The presence of the chemical groups was established with HPLC and Fourier Transform Infra Red. The structures of isolated compounds were elucidated by spectroscopic study and chemical shifts. Data from the study indicates that all the fractionates contain compounds with free radical scavenging activity. This activity was more pronounced in the aqueous fractionate (DPPH IC₅₀, 0025 ± 0.011 mg/ml, metal chelating capacity 27.5%, OH- scavenging IC₅₀, 0.846 ± 0.037 mg/ml, H₂O₂ scavenging IC₅₀ 0.521 ± 0.015 mg/ml, reducing power IC₅₀ 0.248 ± 0.025 mg/ml and NO scavenging IC₅₀ 0.537 ± 0.038 mg/ml). Two compounds were isolated and when compared with data from the literature; the structures were suggestive of polyphenolic flavonoid, quercetin and 3-O-β-D-glucopyranosyl-sitosterol. The result indicates that H. bonariensis leaves contain bioactive compounds with antioxidant activity. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antioxidant" title="antioxidant">antioxidant</a>, <a href="https://publications.waset.org/abstracts/search?q=cataract" title=" cataract"> cataract</a>, <a href="https://publications.waset.org/abstracts/search?q=free%20radical" title=" free radical"> free radical</a>, <a href="https://publications.waset.org/abstracts/search?q=flavonoids" title=" flavonoids"> flavonoids</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrocotyl%20bonariensis" title=" hydrocotyl bonariensis"> hydrocotyl bonariensis</a> </p> <a href="https://publications.waset.org/abstracts/72069/free-raducal-scavenging-activity-of-fractionated-extract-and-structural-elucidation-of-isolated-compounds-from-hydrocotyl-bonariensis-comm-ex-lam-leaves" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/72069.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">270</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2117</span> Phytochemical and in vitro Antimicrobial Screening of Extract of Sunflower Chrysanthlum indicum</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=I.%20Ibrahim">I. Ibrahim</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Mann"> A. Mann</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Phytochemical screening of crude Chrysanthlum Indicum revealed the presence of carbohydrates, flavonoids, saponins, tannins, alkanoids, steroidal nucleus and cardiac glycosides. The extract was evaluated against some pathogenic organisms by agar dilution method. The minimum inhibitory concentration and minimum bacteriocidal concentration (MBC) of the active extract of Chrysanthlum Indicum shows that its extract could be a potential source of antimicrobial agents. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=extract" title="extract">extract</a>, <a href="https://publications.waset.org/abstracts/search?q=phytochemicals" title=" phytochemicals"> phytochemicals</a>, <a href="https://publications.waset.org/abstracts/search?q=antimicrobial" title=" antimicrobial"> antimicrobial</a>, <a href="https://publications.waset.org/abstracts/search?q=antibacterial" title=" antibacterial"> antibacterial</a>, <a href="https://publications.waset.org/abstracts/search?q=Chrysanthlum%20indicum" title=" Chrysanthlum indicum "> Chrysanthlum indicum </a> </p> <a href="https://publications.waset.org/abstracts/15042/phytochemical-and-in-vitro-antimicrobial-screening-of-extract-of-sunflower-chrysanthlum-indicum" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/15042.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">570</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2116</span> Phytochemical Screening and Toxicological Studies of Aqueous Stem Bark Extract of Boswellia papyrifera (DEL) in Rats</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Y.%20Abdulmumin">Y. Abdulmumin</a>, <a href="https://publications.waset.org/abstracts/search?q=K.%20I.%20Matazu"> K. I. Matazu</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20M.%20Wudil"> A. M. Wudil</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20J.%20Alhassan"> A. J. Alhassan</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20A.%20Imam"> A. A. Imam </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Phytochemical analysis of Boswellia papryfera confirms the presence of various phytochemicals such as alkaloids, flavonoids, tannins, saponins and cardiac glycosides in its aqueous stem bark extract at different concentration, with tannins being the highest (0.611 ± 0.002 g %). Acute toxicity test (LD50, oral, rat) of the extract showed no mortality at up to 5000 mg/kg and the animals were found active and healthy. The extract was declared as practically non-toxic, this suggest the safety of the extract in traditional medicine. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=acute%20toxicity" title="acute toxicity">acute toxicity</a>, <a href="https://publications.waset.org/abstracts/search?q=aqueous%20extract" title=" aqueous extract"> aqueous extract</a>, <a href="https://publications.waset.org/abstracts/search?q=boswellia%20papryfera" title=" boswellia papryfera"> boswellia papryfera</a>, <a href="https://publications.waset.org/abstracts/search?q=phytochemicals%20and%20stem%20bark" title=" phytochemicals and stem bark"> phytochemicals and stem bark</a> </p> <a href="https://publications.waset.org/abstracts/34095/phytochemical-screening-and-toxicological-studies-of-aqueous-stem-bark-extract-of-boswellia-papyrifera-del-in-rats" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/34095.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">456</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2115</span> Antioxydant Activity of Flavonoïd’s Extracts of Rhamnus alaternus L. Leaves of Tessala Mountains (Occidental Algeria)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Benchiha%20Walid">Benchiha Walid</a>, <a href="https://publications.waset.org/abstracts/search?q=Mahroug%20Samira"> Mahroug Samira</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Rhamnus alaternus L. is a shrub that belongs to the family of Rhamnaceae. It is a medicinal plant that is largely used in traditional medicine in Algeria. Five flavonoic extracts obtained of Rhamnus alaternus L. leaves. The flavonoids were evaluated by a method that uses aluminum chloride AlCl3 of each extract; the content is estimated at 19.33 (Hexanic. Extract), 18.42 (Chlroformic.extract), 16.75 (Acetate. Extract), 3.9 (Brute. Extract), and 3.02 (Aqueous. Extract) mg Equivalent quercetine/gram of extract (mg QE/ g extract). The antioxidant activity was realized by the antiradical test that was evaluated by using DPHH (2.2 diphenyl-1-1picrylhdrazile), the inhibitory concentration at 50% (CI50) were estimated at 74.78 (Vitamin.C), 143.78 (Catechine), 101.78 (Gallic acid), 205.41 (Tannic acid), 210 (Caffeic acid) µg/ml; 74.16 (Br.extr), 9.98 (Aq.extr), 54.08 (Hèx.extr), 8.64 (Ac.extr), 30.49 (Ch.extr) mg/ml. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rhamnus%20alaternus%20L." title="Rhamnus alaternus L.">Rhamnus alaternus L.</a>, <a href="https://publications.waset.org/abstracts/search?q=flavonoids" title=" flavonoids"> flavonoids</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxydant%20activity" title=" antioxydant activity"> antioxydant activity</a>, <a href="https://publications.waset.org/abstracts/search?q=Tessala" title=" Tessala"> Tessala</a> </p> <a href="https://publications.waset.org/abstracts/31838/antioxydant-activity-of-flavonoids-extracts-of-rhamnus-alaternus-l-leaves-of-tessala-mountains-occidental-algeria" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/31838.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">531</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2114</span> Emerging Therapeutic Approach with Dandelion Phytochemicals in Breast Cancer Treatment</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Angel%20Champion">Angel Champion</a>, <a href="https://publications.waset.org/abstracts/search?q=Sadia%20Kanwal"> Sadia Kanwal</a>, <a href="https://publications.waset.org/abstracts/search?q=Rafat%20Siddiqui"> Rafat Siddiqui</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Harnessing phytochemicals from plant sources presents a novel opportunity to prevent or treat malignant diseases, including breast cancer. Chemotherapy lacks precision in targeting cancerous cells while sparing normal cells, but a phytopharmaceutical approach may offer a solution. Dandelion, a common weed plant, is rich in phytochemicals and provides a safer, more cost-effective alternative with lower toxicity than traditional pharmaceuticals for conditions such as breast cancer. In this study, an in-vitro experiment will be conducted using the ethanol extract of Dandelion on triple-negative MDA-231 breast cancer cell lines. The polyphenolic analysis revealed that the Dandelion extract, particularly from the root and leaf (both cut and sifted), had the most potent antioxidant properties and exhibited the most potent antioxidation activity from the powdered leaf extract. The extract exhibits prospective promising effects for inducing cell proliferation and apoptosis in breast cancer cells, highlighting its potential for targeted therapeutic interventions. Standardizing methods for Dandelion use is crucial for future clinical applications in cancer treatment. Combining plant-derived compounds with cancer nanotechnology holds the potential for effective strategies in battling malignant diseases. Utilizing liposomes as carriers for phytoconstituent anti-cancer agents offers improved solubility, bioavailability, immunoregulatory effects, advancing anticancer immune function, and reducing toxicity. This integrated approach of natural products and nanotechnology has significant potential to revolutionize healthcare globally, especially in underserved communities where herbal medicine is prevalent. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=apoptosis" title="apoptosis">apoptosis</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidant%20activity" title=" antioxidant activity"> antioxidant activity</a>, <a href="https://publications.waset.org/abstracts/search?q=cancer%20nanotechnology" title=" cancer nanotechnology"> cancer nanotechnology</a>, <a href="https://publications.waset.org/abstracts/search?q=phytopharmaceutical" title=" phytopharmaceutical"> phytopharmaceutical</a> </p> <a href="https://publications.waset.org/abstracts/184862/emerging-therapeutic-approach-with-dandelion-phytochemicals-in-breast-cancer-treatment" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/184862.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">54</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2113</span> Hypotensive, Free Radical Scavenging and Anti-Lipid Peroxidation Activities of Crataegus azarolus L. Leaves Extracts Growing in Algeria</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Amel%20Bouaziz">Amel Bouaziz</a>, <a href="https://publications.waset.org/abstracts/search?q=Seddik%20Khennouf"> Seddik Khennouf</a>, <a href="https://publications.waset.org/abstracts/search?q=Mussa%20Abu%20Zarga"> Mussa Abu Zarga</a>, <a href="https://publications.waset.org/abstracts/search?q=Shtayway%20Abdalla"> Shtayway Abdalla</a>, <a href="https://publications.waset.org/abstracts/search?q=Saliha%20Djidel"> Saliha Djidel</a>, <a href="https://publications.waset.org/abstracts/search?q=Assia%20Bentahar"> Assia Bentahar</a>, <a href="https://publications.waset.org/abstracts/search?q=Saliha%20Dahamna"> Saliha Dahamna</a>, <a href="https://publications.waset.org/abstracts/search?q=Smain%20Amira"> Smain Amira</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The present study aimed to evaluate the hypotensive and the in vitro antioxidant activities of Crataegus azarolus L. (Rosaceae), a plant widely used as natural remedy for hypertension in folk medicine. The antioxidant potential of methanolic extract (ME)and its three fractions of Chloroform (CHE), ethyl acetate (EAE)and water (AqE) have been investigated using several assays, including the DPPH scavenging, ABTS scavenging, hydroxyl radical scavenging. Inhibition of lipid peroxidation was performed by the β-carotene bleaching assay, ferric thiocyanate method and thiobarburic acid method. Total phenolic and total flavonoid contents of the extracts were estimated using Folin-Chiocalteu reagent and AlCl3, respectively. EAE extract showed the highest polyphenolic and flavonoids contents (396,04±1.20 mg GAE/g of dry extract and 32,73 ± 0.03mg QE/g of dry extract) respectively. Similarly, this extract possessed the highest scavenging activity for DPPH radical (IC 50 = 0,006±0,0001mg /ml), ABTS radical (IC50=0.0035±0,0007 mg/ml) and hydroxyl radical(IC 50=0,283± 0.01 mg/ml). In addition, the EAE exhibited the highest antioxidant activity in the inhibition of linoleic acid/ß-carotene coupled oxidation (89,21%), lipid peroxidation in the ferric thiocyanate(FTC) method (90.13%), and thio-barbituric acid (TBA) method (74.23%). Intravenous administration of Me and EAE decreased mean arterial blood pressure, systolic and diastolic blood pressure in anesthetized rats dose-dependently, at the dose range of 0.4 to 12 mg/kg. The mean arterial blood pressure dropped by 27.58 and 39.37% for ME and EAE, respectively. In conclusion, The present study supported the significant potential to use C. azarolus by-products as a source of natural antioxidants and provides scientific justification for its traditional uses as cardio-protective and anti-hypertensive remedy. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Crataegus%20azarolus" title="Crataegus azarolus">Crataegus azarolus</a>, <a href="https://publications.waset.org/abstracts/search?q=polyphenols" title=" polyphenols"> polyphenols</a>, <a href="https://publications.waset.org/abstracts/search?q=flavonoids" title=" flavonoids"> flavonoids</a>, <a href="https://publications.waset.org/abstracts/search?q=hypertension" title=" hypertension"> hypertension</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidant%20activity" title=" antioxidant activity"> antioxidant activity</a>, <a href="https://publications.waset.org/abstracts/search?q=free%20radicals" title=" free radicals"> free radicals</a>, <a href="https://publications.waset.org/abstracts/search?q=peroxidation" title=" peroxidation"> peroxidation</a> </p> <a href="https://publications.waset.org/abstracts/10557/hypotensive-free-radical-scavenging-and-anti-lipid-peroxidation-activities-of-crataegus-azarolus-l-leaves-extracts-growing-in-algeria" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/10557.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">347</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2112</span> Determining the Effective Substance of Cottonseed Extract on the Treatment of Leishmaniasis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mehrosadat%20Mirmohammadi">Mehrosadat Mirmohammadi</a>, <a href="https://publications.waset.org/abstracts/search?q=Sara%20Taghdisi"> Sara Taghdisi</a>, <a href="https://publications.waset.org/abstracts/search?q=Ali%20Padash"> Ali Padash</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammad%20Hossein%20Pazandeh"> Mohammad Hossein Pazandeh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Gossypol, a yellowish anti-nutritional compound found in cotton plants, exists in various plant parts, including seeds, husks, leaves, and stems. Chemically, gossypol is a potent polyphenolic aldehyde with antioxidant and therapeutic properties. However, its free form can be toxic, posing risks to both humans and animals. Initially, we extracted gossypol from cotton seeds using n-hexane as a solvent (yield: 84.0 ± 4.0%). We also obtained cotton seed and cotton boll extracts via Soxhlet extraction (25:75 hydroalcoholic ratio). These extracts, combined with cornstarch, formed four herbal medicinal formulations. Ethical approval allowed us to investigate their effects on Leishmania-caused skin wounds, comparing them to glucantime (local ampoule). Herbal formulas outperformed the control group (ethanol only) in wound treatment (p-value 0.05). The average wound diameter after two months did not significantly differ between plant extract ointments and topical glucantime. Notably, cotton boll extract with 1% extra gossypol crystal showed the best therapeutic effect. We extracted gossypol from cotton seeds using n-hexane via Soxhlet extraction. Saponification, acidification, and recrystallization steps followed. FTIR, UV-Vis, and HPLC analyses confirmed the product’s identity. Herbal medicines from cotton seeds effectively treated chronic wounds compared to the ethanol-only control group. Wound diameter differed significantly between extract ointments and glucantime injections. It seems that due to the presence of large amounts of fat in the oil, the extraction of gossypol from it faces many obstacles. The extraction of this compound with our technique showed that extraction from oil has a higher efficiency, perhaps because of the preparation of oil by cold pressing method, the possibility of losing this compound is much less than when extraction is done with Soxhlet. On the other hand, the gossypol in the oil is mostly bound to the protein, which somehow protects the gossypol until the last stage of the extraction process. Since this compound is very sensitive to light and heat, it was extracted as a derivative with acetic acid. Also, in the treatment section, it was found that the ointment prepared with the extract is more effective and Gossypol is one of the effective ingredients in the treatment. Therefore, gossypol can be extracted from the oil and added to the extract from which gossypol has been extracted to make an effective medicine with a certain dose. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cottonseed" title="cottonseed">cottonseed</a>, <a href="https://publications.waset.org/abstracts/search?q=glucantime" title=" glucantime"> glucantime</a>, <a href="https://publications.waset.org/abstracts/search?q=gossypol" title=" gossypol"> gossypol</a>, <a href="https://publications.waset.org/abstracts/search?q=leishmaniasis" title=" leishmaniasis"> leishmaniasis</a> </p> <a href="https://publications.waset.org/abstracts/184864/determining-the-effective-substance-of-cottonseed-extract-on-the-treatment-of-leishmaniasis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/184864.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">61</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2111</span> Development and Validation of a HPLC Method for Standardization of Methanolic Extract of Hypericum sinaicum Hochst</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Taghreed%20A.%20Ibrahim">Taghreed A. Ibrahim</a>, <a href="https://publications.waset.org/abstracts/search?q=Atef%20A.%20El-Hela"> Atef A. El-Hela</a>, <a href="https://publications.waset.org/abstracts/search?q=Hala%20M.%20El-Hefnawy"> Hala M. El-Hefnawy</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The chromatographic profile of methanol extract of Hypericum sinaicum was determined using HPLC-DAD. Apigenin was used as an external standard in the development and validation of the HPLC method. The proposed method is simple, rapid and reliable and can be successfully applied for standardization of Hypericum sinaicum methanol extract. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=quality%20control" title="quality control">quality control</a>, <a href="https://publications.waset.org/abstracts/search?q=standardization" title=" standardization"> standardization</a>, <a href="https://publications.waset.org/abstracts/search?q=falvonoids" title=" falvonoids"> falvonoids</a>, <a href="https://publications.waset.org/abstracts/search?q=methanol%20extract" title=" methanol extract"> methanol extract</a> </p> <a href="https://publications.waset.org/abstracts/15989/development-and-validation-of-a-hplc-method-for-standardization-of-methanolic-extract-of-hypericum-sinaicum-hochst" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/15989.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">503</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2110</span> Antibacterial and Anti-Biofilm Activity of Vaccinium meridionale S. Pomace Extract Against Staphylococcus aureus, Escherichia coli and Salmonella Enterica</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Carlos%20Y.%20Soto">Carlos Y. Soto</a>, <a href="https://publications.waset.org/abstracts/search?q=Camila%20A.%20Lota"> Camila A. Lota</a>, <a href="https://publications.waset.org/abstracts/search?q=G.%20Astrid%20Garz%C3%B3n"> G. Astrid Garzón</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Bacterial biofilms cause an ongoing problem for food safety. They are formed when microorganisms aggregate to form a community that attaches to solid surfaces. Biofilms increase the resistance of pathogens to cleaning, disinfection and antibacterial products. This resistance gives rise to problems for human health, industry, and agriculture. At present, plant extracts rich in polyphenolics are being investigated as natural alternatives to degrade bacterial biofilms. The pomace of the tropical Berry Vaccinium meridionale S. contains high amounts of phenolic compounds. Therefore, in the current study, the antimicrobial and antibiofilm effects of extracts from the pomace of Vaccinium meridionale S. were tested on three foodborne pathogens: Enterohaemorrhagic Escherichia coli O157:H7 (ATCC®700728TM), Staphylococcus aureus subsp. aureus (ATCC® 6538TM), and Salmonella enterica serovar Enteritidis (ATCC® 13076TM). Microwave-assisted extraction was used to extract polyphenols with aqueous methanol (80% v/v) at a solid to solvent ratio of 1:10 (w/v) for 20 min. The magnetic stirring was set at 400 rpm, and the microwave power was adjusted to 400 W. The antimicrobial effect of the extract was assessed by determining the half maximal inhibitory concentration (IC50) against the three food poisoning pathogens at concentrations ranging from 50 to 2,850 μg gallic acid equivalents (GAE)/mL of the extract. Biofilm inhibition was assessed using a crystal violet assay applying the same range of concentration. Three replications of the experiments were carried out, and all analyses were run in triplicate. IC50 values were determined using the GraphPad Prism8® program. Significant differences (P<0.05) among means were identified using one-factor analysis of variance (ANOVA) and the post-hoc least significant difference (LSD) test using the Statgraphics plus program, version 2.1.There was significant difference among the mean IC50 values for the tested bacteria. The IC50 for S. aureus was 48 ± 9 μg GAE/mL, followed by 123 ± 49 μg GAE/mL for Salmonella and 376 ± 32 μg GAE/mL for E. coli. The percent inhibition of the extract on biofilm formation was significantly higher for S. aureus (85.8  0.3), followed by E. coli (74.5  1.0) and Salmonella (53.6  9.7). These findings suggest that polyphenolic extracts obtained from the pomace of V. meridionale S. might be used as natural antimicrobial and anti-biofilm natural agents, effective against S. aureus, E. coli and Salmonella enterica. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antibiofilm" title="antibiofilm">antibiofilm</a>, <a href="https://publications.waset.org/abstracts/search?q=antimicrobial" title=" antimicrobial"> antimicrobial</a>, <a href="https://publications.waset.org/abstracts/search?q=E.%20coli" title=" E. coli"> E. coli</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20aureus" title=" S. aureus"> S. aureus</a>, <a href="https://publications.waset.org/abstracts/search?q=salmonella" title=" salmonella"> salmonella</a>, <a href="https://publications.waset.org/abstracts/search?q=IC50" title=" IC50"> IC50</a>, <a href="https://publications.waset.org/abstracts/search?q=pomace" title=" pomace"> pomace</a>, <a href="https://publications.waset.org/abstracts/search?q=V.%20meridionale" title=" V. meridionale"> V. meridionale</a> </p> <a href="https://publications.waset.org/abstracts/177951/antibacterial-and-anti-biofilm-activity-of-vaccinium-meridionale-s-pomace-extract-against-staphylococcus-aureus-escherichia-coli-and-salmonella-enterica" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/177951.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">63</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2109</span> Optimation of Ethanol Extract of Gotu Kola and Majapahit Composition as Natural Antioxidant Source </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mustofa%20Ahda">Mustofa Ahda</a>, <a href="https://publications.waset.org/abstracts/search?q=Fiqri%20Rozi"> Fiqri Rozi</a>, <a href="https://publications.waset.org/abstracts/search?q=Gina%20Noor%20Habibah"> Gina Noor Habibah</a>, <a href="https://publications.waset.org/abstracts/search?q=Mas%20Ulfah%20Lestari"> Mas Ulfah Lestari</a>, <a href="https://publications.waset.org/abstracts/search?q=Tomy%20Hardianto"> Tomy Hardianto</a>, <a href="https://publications.waset.org/abstracts/search?q=Yuni%20Andriani"> Yuni Andriani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The development of natural antioxidants in the Centella asiatica and Majapahit is a great potential. This research has been optimizing the composition of ethanol extract of Centella asiatica and leaves Majapahit as an antioxidants source using measure the free radical scavenging activity of DPPH. The results of the research showed that both the ethanol extract of Centella asiatica and leaves Majapahit has a total content of phenol. It is shown with the ability to reduce reagent Folin Ciocalteu become blue colour. The composition optimization of extract Centella asiatica leaves Majapahit = 30:70 has free radical scavenging activity of DPPH most well compared ethanol extract of Centella asiatica and leaves Majapahit. IC50 values for the composition of ethanol extract of Centella asiatica : leaves Majapahit = 30:70 is 0,103 mg/mL. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=antioxidant%20activity" title="antioxidant activity">antioxidant activity</a>, <a href="https://publications.waset.org/abstracts/search?q=Centella%20asiatica" title=" Centella asiatica"> Centella asiatica</a>, <a href="https://publications.waset.org/abstracts/search?q=Cresentia%20cujete" title=" Cresentia cujete"> Cresentia cujete</a>, <a href="https://publications.waset.org/abstracts/search?q=composition%20extract" title=" composition extract"> composition extract</a> </p> <a href="https://publications.waset.org/abstracts/66718/optimation-of-ethanol-extract-of-gotu-kola-and-majapahit-composition-as-natural-antioxidant-source" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/66718.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">329</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2108</span> The Comparison Study of Methanol and Water Extract of Chuanxiong Rhizoma: A Fingerprint Analysis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Li%20Chun%20Zhao">Li Chun Zhao</a>, <a href="https://publications.waset.org/abstracts/search?q=Zhi%20Chao%20Hu"> Zhi Chao Hu</a>, <a href="https://publications.waset.org/abstracts/search?q=Xi%20Qiang%20Liu"> Xi Qiang Liu</a>, <a href="https://publications.waset.org/abstracts/search?q=Man%20Lai%20Lee"> Man Lai Lee</a>, <a href="https://publications.waset.org/abstracts/search?q=Chak%20Shing%20Yeung"> Chak Shing Yeung</a>, <a href="https://publications.waset.org/abstracts/search?q=Man%20Fei%20Xu"> Man Fei Xu</a>, <a href="https://publications.waset.org/abstracts/search?q=Yuen%20Yee%20Kwan"> Yuen Yee Kwan</a>, <a href="https://publications.waset.org/abstracts/search?q=Alan%20H.%20M.%20Ho"> Alan H. M. Ho</a>, <a href="https://publications.waset.org/abstracts/search?q=Nickie%20W.%20K.%20Chan"> Nickie W. K. Chan</a>, <a href="https://publications.waset.org/abstracts/search?q=Bin%20Deng"> Bin Deng</a>, <a href="https://publications.waset.org/abstracts/search?q=Zhong%20Zhen%20Zhao"> Zhong Zhen Zhao</a>, <a href="https://publications.waset.org/abstracts/search?q=Min%20Xu"> Min Xu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Chuangxiong Rhizoma (Chuangxion, CX) is one of the most frequently used herbs in Chinese medicine because of its wide therapeutic effects such as vasorelaxation and anti-inflammation. Aim: The purposes of this study are (1) to perform non-targeted / targeted analyses of CX methanol extract and water extract, and compare the present data with previously LC-MS or GC-MS fingerprints; (2) to examine the difference between CX methanol extract and water extract for preliminarily evaluating whether current compound markers of methanol extract from crude CX materials could be suitable for quality control of CX water extract. Method: CX methanol extract was prepared according to the Hong Kong Chinese Materia Medica Standards. DG water extract was prepared by boiling with pure water for three times (one hour each). UHPLC-Q-TOF-MS/MS fingerprint analysis was performed by C18 column (1.7 µm, 2.1 × 100 mm) with Agilent 1290 Infinity system. Experimental data were analyzed by Agilent MassHunter Software. A database was established based on 13 published LC-MS and GC-MS CX fingerprint analyses. Total 18 targeted compounds in database were selected as markers to compare present data with previous data, and these markers also used to compare CX methanol extract and water extract. Result: (1) Non-targeted analysis indicated that there were 133 compounds identified in CX methanol extract, while 325 compounds in CX water extract that was more than double of CX methanol extract. (2) Targeted analysis further indicated that 9 in 18 targeted compounds were identified in CX methanol extract, while 12 in 18 targeted compounds in CX water extract that showed a lower lose-rate of water extract when compared with methanol extract. (3) By comparing CX methanol extract and water extract, Senkyunolide A (+1578%), Ferulic acid (+529%) and Senkyunolide H (+169%) were significantly higher in water extract when compared with methanol extract. (4) Other bioactive compounds such as Tetramethylpyrazine were only found in CX water extract. Conclusion: Many new compounds in both CX methanol and water extracts were found by using UHPLC Q-TOF MS/MS analysis when compared with previous published reports. A new standard reference including non-targeted compound profiling and targeted markers functioned especially for quality control of CX water extract (herbal decoction) should be established in future. (This project was supported by Hong Kong Baptist University (FRG2/14-15/109) & Natural Science Foundation of Guangdong Province (2014A030313414)). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Chuanxiong%20rhizoma" title="Chuanxiong rhizoma">Chuanxiong rhizoma</a>, <a href="https://publications.waset.org/abstracts/search?q=fingerprint%20analysis" title=" fingerprint analysis"> fingerprint analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=targeted%20analysis" title=" targeted analysis"> targeted analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=quality%20control" title=" quality control"> quality control</a> </p> <a href="https://publications.waset.org/abstracts/71796/the-comparison-study-of-methanol-and-water-extract-of-chuanxiong-rhizoma-a-fingerprint-analysis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/71796.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">495</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2107</span> Antioxidative Effect of Bauhinia acuminata Water Extract Consumption in Rat</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Amornnat%20Thuppia">Amornnat Thuppia</a>, <a href="https://publications.waset.org/abstracts/search?q=Pornrut%20Rabintossaporn"> Pornrut Rabintossaporn</a>, <a href="https://publications.waset.org/abstracts/search?q=Suphaket%20Saenthaweesuk"> Suphaket Saenthaweesuk</a>, <a href="https://publications.waset.org/abstracts/search?q=Nuntiya%20Somparn"> Nuntiya Somparn</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The aim of this present study was to determine the antioxidant effects and its mechanism of aqueous leaves extract of Bauhinia acuminata (BA) in rat. The extract was screened for its phytochemical contents and antioxidant activity in vitro. Moreover, the extract was studied in rats to evaluate its effects in vivo. Rats were orally administered with the extract at the dose of 50, 100 and 200 mg/kg for 28 days. Phytochemical screening of plant extracts showed the presence of saponin, alkaloid, cardiac glycosides, flavonoids, tannin and steroid compounds. The extract contained phenolic compounds 53.36 ± 1.01 mg of gallic acid equivalents per gram BA extract. The free radical scavenging activity assessed by DPPH assay gave IC50 of 44.47 ± 2.83 µg/mL, which is relatively lower than that of BHT with IC50 of 12.34 ± 1.14µg/mL. In the animals, the extract was well tolerated by the animals throughout the 28 days of study as shown by normal serum levels AST, ALP, ALT, BUN and Cr as well as normal histology of liver and pancreatic and kidney tissue. Significantly, reduction of serum oxidative stress markers malondialdehyde (MDA) was found in rat treated with BA extract compared with control. Taken together, this study provides evidence that Bauhinia acuminata (BA) exhibits direct antioxidant properties and induces cytoprotective enzyme in vivo. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bauhinia%20acuminata" title="Bauhinia acuminata">Bauhinia acuminata</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidant" title=" antioxidant"> antioxidant</a>, <a href="https://publications.waset.org/abstracts/search?q=malondialdehyde%20%28MDA%29" title=" malondialdehyde (MDA)"> malondialdehyde (MDA)</a>, <a href="https://publications.waset.org/abstracts/search?q=oxidative%20marker" title=" oxidative marker"> oxidative marker</a> </p> <a href="https://publications.waset.org/abstracts/69547/antioxidative-effect-of-bauhinia-acuminata-water-extract-consumption-in-rat" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/69547.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">273</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2106</span> Studying the Effect of Reducing Thermal Processing over the Bioactive Composition of Non-Centrifugal Cane Sugar: Towards Natural Products with High Therapeutic Value</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Laura%20Rueda-Gensini">Laura Rueda-Gensini</a>, <a href="https://publications.waset.org/abstracts/search?q=Jader%20Rodr%C3%ADguez"> Jader Rodríguez</a>, <a href="https://publications.waset.org/abstracts/search?q=Juan%20C.%20Cruz"> Juan C. Cruz</a>, <a href="https://publications.waset.org/abstracts/search?q=Carolina%20Munoz-Camargo"> Carolina Munoz-Camargo</a> </p> <p class="card-text"><strong>Abstract:</strong></p> There is an emerging interest in botanicals and plant extracts for medicinal practices due to their widely reported health benefits. A large variety of phytochemicals found in plants have been correlated with antioxidant, immunomodulatory, and analgesic properties, which makes plant-derived products promising candidates for modulating the progression and treatment of numerous diseases. Non-centrifugal cane sugar (NCS), in particular, has been known for its high antioxidant and nutritional value, but composition-wise variability due to changing environmental and processing conditions have considerably limited its use in the nutraceutical and biomedical fields. This work is therefore aimed at assessing the effect of thermal exposure during NCS production over its bioactive composition and, in turn, its therapeutic value. Accordingly, two modified dehydration methods are proposed that employ: (i) vacuum-aided evaporation, which reduces the necessary temperatures to dehydrate the sample, and (ii) window refractance evaporation, which reduces thermal exposure time. The biochemical composition of NCS produced under these two methods was compared to traditionally-produced NCS by estimating their total polyphenolic and protein content with Folin-Ciocalteu and Bradford assays, as well as identifying the major phenolic compounds in each sample via HPLC-coupled mass spectrometry. Their antioxidant activities were also compared as measured by their scavenging potential of ABTS and DPPH radicals. Results show that the two modified production methods enhance polyphenolic and protein yield in resulting NCS samples when compared to traditional production methods. In particular, reducing employed temperatures with vacuum-aided evaporation demonstrated to be superior at preserving polyphenolic compounds, as evidenced both in the total and individual polyphenol concentrations. However, antioxidant activities were not significantly different between these. Although additional studies should be performed to determine if the observed compositional differences affect other therapeutic activities (e.g., anti-inflammatory, analgesic, and immunoprotective), these results suggest that reducing thermal exposure holds great promise for the production of natural products with enhanced nutritional value. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=non-centrifugal%20cane%20sugar" title="non-centrifugal cane sugar">non-centrifugal cane sugar</a>, <a href="https://publications.waset.org/abstracts/search?q=polyphenolic%20compounds" title=" polyphenolic compounds"> polyphenolic compounds</a>, <a href="https://publications.waset.org/abstracts/search?q=thermal%20processing" title=" thermal processing"> thermal processing</a>, <a href="https://publications.waset.org/abstracts/search?q=antioxidant%20activity" title=" antioxidant activity"> antioxidant activity</a> </p> <a href="https://publications.waset.org/abstracts/146800/studying-the-effect-of-reducing-thermal-processing-over-the-bioactive-composition-of-non-centrifugal-cane-sugar-towards-natural-products-with-high-therapeutic-value" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/146800.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">91</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=polyphenolic%20extract&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=polyphenolic%20extract&page=3">3</a></li> <li class="page-item"><a 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