Early Clinical | Solutions

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src="https://icon.widen.net/content/b8271dec-3d17-4a31-8956-c7cf7627bede/web/MDD_obesity_2025.jpeg?crop=yes&w=260&h=136&itok=abXIocYn" width="260" height="136" alt="Obesity 2025 insights image" loading="eager" title="Obesity 2025 insights image" /> </div> </div> </div> <span class="h4">Obesity</span> <p class="section-overview--desktop">A focus on combination therapies requires appropriate obesity-specific trial designs, long-term follow-up studies and diverse patient recruitment.</p> </a> </div> <div class="col-xl-3"> <a href="/insights/therapeutics" class="dropdown-item dropdown-item--with-image"> <div class="image image--zoom-on-hover"> <div><div><img src="https://icon.widen.net/content/78559377-8cc3-4bc6-b6f2-cc20a04e1504/web/cells-menu-hero.jpg?crop=yes&w=260&h=136&itok=Gl34jPGP" width="260" height="136" alt="cells-menu-hero.jpg" loading="eager" title="cells-menu-hero.jpg" /> </div> </div> </div> <span class="h4">Therapeutics insights</span> <p class="section-overview--desktop">ICON's therapeutic experts contribute regularly to industry publications and the creation of thought leadership content. Read more. </p> </a> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a href="/insights" aria-expanded="false" class="nav-link dropdown-toggle" data-toggle="dropdown" role="button"> Insights <span></span> </a> <div class="menu_link_content menu-link-contentmain view-mode-main-navigation dropdown-menu"> <button class="navbar-btn navbar-btn--back" type="button" aria-label="Back button"> <span class="navbar-btn__icon"></span> </button> <div class="container-fluid container-fluid--xl"> <div class="row"> <div class="col-xl-3"> <div class="paragraph paragraph--type--mega-menu-text paragraph--view-mode--default"> <div class="mega-menu-title"><a href="/insights" target="_self">Insights</a></div> </div> <a class="dropdown-item" href="/insights/digital-disruption">Digital Disruption</a> <a class="dropdown-item" href="/insights/patient-centricity">Patient Centricity</a> <a class="dropdown-item" href="/insights/regulatory-intelligence">Regulatory Intelligence</a> <a 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class="h4">Streamlining dossier preparation</span> <p class="section-overview--desktop">Best practices on how to organise the cross-functional team, develop the project plan, and manage the review process</p> </a> </div> <div class="col-xl-3"> <a href="/insights/therapeutics/central-nervous-system/advancing-alzheimers-parkinsons-rnd" class="dropdown-item dropdown-item--with-image"> <div class="image image--zoom-on-hover"> <div><div><img src="https://icon.widen.net/content/2343922f-d240-4d8c-997e-0223099295d8/web/biotech_cns_whitepaper_advancing%20alzheimers%20rnd_Homepage%20banner.jpeg?crop=yes&w=260&h=136&itok=-Qge2L_A" width="260" height="136" alt="whitepaper CNS" loading="eager" title="whitepaper CNS" /> </div> </div> </div> <span class="h4">Early, precise and efficient; the methods and technologies advancing Alzheimer’s and Parkinson’s R&D</span> <p class="section-overview--desktop">In this CNS whitepaper we examine how innovative methodologies and technologies are being implemented to improve the success rate of neurodegenerative clinical trials.</p> </a> </div> <div class="col-xl-3"> <a href="/sectors/biotech/early-phase-challenges-biotechs" class="dropdown-item dropdown-item--with-image"> <div class="image image--zoom-on-hover"> <div><div><img src="https://icon.widen.net/content/fc13f816-bd06-455c-a1ae-4daf6cb35f40/web/Thumbnail_biotech_whitepaper.jpeg?crop=yes&w=260&h=136&itok=TiLfrjIJ" width="260" height="136" alt="Early phase challenges for biotechs_whitepaper" loading="eager" title="Early phase challenges for biotechs_whitepaper" /> </div> </div> </div> <span class="h4">Early phase challenges for biotechs</span> <p class="section-overview--desktop">Approaching early phase trials strategically and anticipating obstacles can be critical to the later success of a therapeutic</p> </a> </div> </div> </div> </div> </li> <li class="nav-item dropdown"> <a href="/news-events" aria-expanded="false" class="nav-link dropdown-toggle" data-toggle="dropdown" role="button"> News & Events <span></span> </a> <div class="menu_link_content menu-link-contentmain view-mode-main-navigation dropdown-menu"> <button class="navbar-btn navbar-btn--back" type="button" aria-label="Back button"> <span class="navbar-btn__icon"></span> </button> <div class="container-fluid container-fluid--xl"> <div class="row"> <div class="col-xl-3"> <div class="paragraph paragraph--type--mega-menu-text paragraph--view-mode--default"> <div class="mega-menu-title"><span class="h4">News & Events</span></div> <div class="section-overview--desktop"> <p>ICON regularly contributes thought leadership to industry media publications and conferences, and has been recognised as one of the world’s leading Contract Research Organisations through a number of high-profile industry awards.</p> </div> <a class="dropdown-item section-overview--desktop" href="/news-events">Read more</a> </div> </div> <div class="col-xl-3"> <div class="mega-menu-title"> </div> <a 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Each clinic is supported by the expertise required to successfully deliver the most complex of healthy volunteer, patient, or hybrid first-in-human and proof-of-concept studies.</p></div> </div> </div> </div> </div> </a> </div> <div class="col-sm"> <a href="/solutions/early-clinical/expertise" class="block-link" target="_self"> <div class="container-full"> <div class="card card--title-description card--title-description-blue-light text-left"> <div class="card-body" data-mh="card-body"> <span class="icon-ui-arrow-right"></span> <h4 class="card-title">Clinical Pharmacology</h4> <div class="card-text small"> <div><p>Across all elements of your program from development plan to clinical study report, we apply integrated medical, scientific and operational excellence that’s dedicated to early phase development essential to reaching decision milestones on-time and with the highest quality insights.</p></div> </div> </div> </div> </div> </a> </div> <div class="col-sm"> <a href="/solutions/early-clinical/volunteer-recruitment" class="block-link" target="_self"> <div class="container-full"> <div class="card card--title-description card--title-description-purple text-left"> <div class="card-body" data-mh="card-body"> <span class="icon-ui-arrow-right"></span> <h4 class="card-title">Access to healthy volunteer and patient populations</h4> <div class="card-text small"> <div><p>Flexible volunteer recruitment solutions designed to serve the needs of your early phase clinical trial.</p></div> </div> </div> </div> </div> </a> </div> </div> </div> </div> </div> <div id="78085bbe-3125-4aa4-8ac6-cf5dcb082a27"> <div class="lead-text text-left bg-white"> <div class="container-fluid container-fluid--xl"> <h2> Innovative early clinical solutions that will advance your drug development strategy </h2> </div> </div> </div> <div id="8e255a5c-8ce6-4da2-8668-43a3828f18da" class="icon-group icon-group--horizontal"> <div class="container-fluid container-fluid--xl"> <ul class="icon-group__items icon-group__items__columns-3"> <li class="icon-group__item--green"> <div lang="en" class="icon-group__wrapper" > <span class="group-icon icon-sites"></span> <p class="mb-2 icons-large-text">6</p> <small>Clinical research units across Europe and the USA</small> </div> </li> <li class="icon-group__item--blue"> <div lang="en" class="icon-group__wrapper" > <span class="group-icon icon-research"></span> <p class="mb-2 icons-large-text">894</p> <small>Early phase clinical trials over the last 5 years</small> </div> </li> <li class="icon-group__item--purple"> <div lang="en" class="icon-group__wrapper" > <span class="group-icon icon-partnership-2"></span> <p class="mb-2 icons-large-text">32,600</p> <small>Healthy volunteers and patients targeted</small> </div> </li> </ul> </div> </div> <div id="73b5f495-fb6e-409d-9510-9cc657548f9c"> <div class="container-fluid container-fluid--xl text-and-picture-wrapper "> <div class="row"> <div class="col-sm"> <div class="text-picture-wrapper"> <div class="text-picture text-picture--text-only text-left with-separator--top"> <div> <div class="text-picture__text"> <h3> </h3> <div><p>ICON is committed to the highest standards of excellence and scientific expertise in early clinical drug development.</p><p>We have extensive experience in the design, conduct, and interpretation of early phase first-in-human and proof of concept studies, providing the full suite of clinical pharmacology studies, all elements of a regulatory package programme, and translational early efficacy indication solutions in a range of study types including: </p><table style="width:100%;" border="0" cellpadding="1" cellspacing="1"><tbody><tr><td style="vertical-align:top;"><ul><li>Absorption, Metabolism, Excretion, (AME)</li><li>Bioavailability</li><li>Bioequivalence</li><li>Drug-drug interaction</li><li>Food Effect (FE)</li></ul></td><td style="vertical-align:top;"><ul><li>Hepatic Impairment</li><li>Human Abuse Liability</li><li>Microdose</li><li>Multiple Ascending Dose (MAD)</li><li>Phase 1 First in human</li></ul></td><td style="vertical-align:top;"><ul><li>Phase 1b/2a Proof of concept</li><li>Renal Impairment</li><li>Single Ascending Dose (SAD)</li><li>Thorough QT (TQT/) QTc</li></ul></td></tr></tbody></table></div> </div> </div> </div> </div> </div> </div> </div> </div> <div id="d15e969a-fc3c-4480-ae9a-a92e4e291c28"> <div class="container-fluid container-fluid--xl text-and-picture-wrapper "> <div class="row"> <div class="col-sm"> <div class="text-picture-wrapper"> <div class="text-picture text-picture--text-only text-left with-separator--top"> <div> <div class="text-picture__text"> <h3> </h3> <div><p>ICON’s early clinical services deliver full visibility and control to meet the requirements of increasingly complex clinical trial requirements. Our dedicated early phase specialists will engage with you to develop a trial that is best for your compound. Together we will build a tailored approach that leverages our <a href="https://www.iconplc.com/solutions/consulting">asset development consulting</a>, <a href="https://www.iconplc.com/solutions/early-clinical/expertise">clinical pharmacology expertise</a>, <a href="https://www.iconplc.com/solutions/early-clinical/clinical-research-units">extensive research facilities</a>, early phase operational experience, and <a href="https://www.iconplc.com/solutions/early-clinical/data-analysis">biometrics capabilities</a> to conduct your trial within both healthy volunteers and patient populations. </p></div> </div> </div> </div> </div> </div> </div> </div> </div> <div id="5a5f840f-0fea-4dc1-8dd5-30416d685b5e"> <div class="group bg-transparent area-wrapper"> <div class="container-fluid container-fluid--xl"> <div class="area area--nav-left"> <ul class="area__nav area__nav--green"> <li> <a href="/solutions/consulting/asset-development" class="area__nav-item active has-link" target="_self" data-target="#area-item-0-140906-141246"> <span class="area__nav-title">Asset Development Consulting</span> <span class="area__nav-description">In-depth scientific expertise across disciplines.</span> </a> </li> <li> <a href="/solutions/early-phase/expertise" class="area__nav-item has-link" target="_self" data-target="#area-item-1-140906-130380"> <span class="area__nav-title">Clinical Pharmacology</span> <span class="area__nav-description">We help design a protocol that works harder and smarter for you.</span> </a> </li> <li> <a href="/solutions/early-phase/cmc" class="area__nav-item has-link" target="_self" data-target="#area-item-2-140906-130382"> <span class="area__nav-title">Accelerated Pharmaceutical Solutions</span> <span class="area__nav-description">A one stop drug development solution that is perfectly suited for early phase trials with shorter timelines. </span> </a> </li> <li> <a href="/solutions/early-phase/bioanalytical" class="area__nav-item has-link" target="_self" 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container-fluid--xl"> <p class="group__text"> Our dedicated early clinical experts have the experience to address the most demanding early phase drug development challenges including: </p> <div class="row"> <div class="col-sm"> <div class="container-full"> <div class="key-message key-message--standard key-message--standard-blue"> <div class="key-message__body" data-mh="key-message"> <h4 class="key-message__title"> Increasing complexity of trials </h4> </div> <div class="key-message__image"> <div> <div> <picture> <source srcset="https://icon.widen.net/content/knyzqe5x4z/web/homepage-complexity-early-clinical-card.jpg?crop=yes&k=c&w=270&h=270&itok=taHgk3Pr 1x, https://icon.widen.net/content/knyzqe5x4z/web/homepage-complexity-early-clinical-card.jpg?crop=yes&k=c&w=540&h=540&itok=CaLQDmPi 2x" media="(min-width: 1400px)" width="270" height="270"/> <source srcset="https://icon.widen.net/content/knyzqe5x4z/web/homepage-complexity-early-clinical-card.jpg?crop=yes&k=c&w=270&h=270&itok=PLvcE0j3 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</div> </div> </div> <div class="col-sm"> <div class="container-full"> <div class="key-message key-message--standard key-message--standard-blue"> <div class="key-message__body" data-mh="key-message"> <h4 class="key-message__title"> Delivery of reliable safety and efficacy data faster </h4> </div> <div class="key-message__image"> <div> <div> <picture> <source srcset="https://icon.widen.net/content/mxtzwhdrra/web/reliable-data-and-efficacy-early-clinical-card.jpg?crop=yes&k=c&w=270&h=270&itok=onAaxnjO 1x, https://icon.widen.net/content/mxtzwhdrra/web/reliable-data-and-efficacy-early-clinical-card.jpg?crop=yes&k=c&w=540&h=540&itok=JPbvOJs1 2x" media="(min-width: 1400px)" width="270" height="270"/> <source srcset="https://icon.widen.net/content/mxtzwhdrra/web/reliable-data-and-efficacy-early-clinical-card.jpg?crop=yes&k=c&w=270&h=270&itok=y6_IB1VK 1x, https://icon.widen.net/content/mxtzwhdrra/web/reliable-data-and-efficacy-early-clinical-card.jpg?crop=yes&k=c&w=540&h=540&itok=rrpFPiqD 2x" media="(min-width: 1200px)" width="270" height="270"/> <source srcset="https://icon.widen.net/content/mxtzwhdrra/web/reliable-data-and-efficacy-early-clinical-card.jpg?crop=yes&k=c&w=270&h=270&itok=UObhPZze 1x, https://icon.widen.net/content/mxtzwhdrra/web/reliable-data-and-efficacy-early-clinical-card.jpg?crop=yes&k=c&w=540&h=540&itok=7s4Wv15A 2x" media="(min-width: 992px) and (max-width: 1199px)" width="270" height="270"/> <source srcset="https://icon.widen.net/content/mxtzwhdrra/web/reliable-data-and-efficacy-early-clinical-card.jpg?crop=yes&k=c&w=270&h=270&itok=zsx0gM8U 1x, https://icon.widen.net/content/mxtzwhdrra/web/reliable-data-and-efficacy-early-clinical-card.jpg?crop=yes&k=c&w=270&h=270&itok=a8yUttd2 2x" media="(min-width: 768px) and (max-width: 991px)" width="270" height="270"/> <source srcset="https://icon.widen.net/content/mxtzwhdrra/web/reliable-data-and-efficacy-early-clinical-card.jpg?crop=yes&k=c&w=325&h=325&itok=nQaP-Y_U 1x, https://icon.widen.net/content/mxtzwhdrra/web/reliable-data-and-efficacy-early-clinical-card.jpg?crop=yes&k=c&w=650&h=650&itok=ijJALHBz 2x" media="(min-width: 576px) and (max-width: 767px)" width="325" height="325"/> <source srcset="https://icon.widen.net/content/mxtzwhdrra/web/reliable-data-and-efficacy-early-clinical-card.jpg?crop=yes&k=c&w=515&h=515&itok=cXH3CtYI 1x, https://icon.widen.net/content/mxtzwhdrra/web/reliable-data-and-efficacy-early-clinical-card.jpg?crop=yes&k=c&w=515&h=515&itok=cXH3CtYI 2x" media="(max-width: 575px)" width="515" height="515"/> <img src="https://icon.widen.net/content/mxtzwhdrra/web/reliable-data-and-efficacy-early-clinical-card.jpg?crop=yes&k=c&w=515&h=515&itok=cXH3CtYI" width="515" height="515" alt="reliable-data-and-efficacy-early-clinical-card" title="reliable-data-and-efficacy-early-clinical-card" loading="lazy" /> </picture> </div> </div> </div> </div> </div> </div> <div class="col-sm"> <div class="container-full"> <div class="key-message key-message--standard key-message--standard-blue"> <div class="key-message__body" data-mh="key-message"> <h4 class="key-message__title"> Finding the right clinical settings to support complex assessment </h4> </div> <div class="key-message__image"> <div> <div> <picture> <source srcset="https://icon.widen.net/content/yu5rq6zqvl/web/finding-the-right-clinical-settings-early-clinical-card.jpg?crop=yes&k=c&w=270&h=270&itok=vUISB93Z 1x, https://icon.widen.net/content/yu5rq6zqvl/web/finding-the-right-clinical-settings-early-clinical-card.jpg?crop=yes&k=c&w=540&h=540&itok=gE4n7y_Z 2x" media="(min-width: 1400px)" width="270" height="270"/> <source srcset="https://icon.widen.net/content/yu5rq6zqvl/web/finding-the-right-clinical-settings-early-clinical-card.jpg?crop=yes&k=c&w=270&h=270&itok=9_oRSkUu 1x, https://icon.widen.net/content/yu5rq6zqvl/web/finding-the-right-clinical-settings-early-clinical-card.jpg?crop=yes&k=c&w=540&h=540&itok=Q9BFawuq 2x" media="(min-width: 1200px)" width="270" height="270"/> <source srcset="https://icon.widen.net/content/yu5rq6zqvl/web/finding-the-right-clinical-settings-early-clinical-card.jpg?crop=yes&k=c&w=270&h=270&itok=NGBSyPYH 1x, https://icon.widen.net/content/yu5rq6zqvl/web/finding-the-right-clinical-settings-early-clinical-card.jpg?crop=yes&k=c&w=540&h=540&itok=6FUeVscv 2x" media="(min-width: 992px) and (max-width: 1199px)" width="270" height="270"/> <source srcset="https://icon.widen.net/content/yu5rq6zqvl/web/finding-the-right-clinical-settings-early-clinical-card.jpg?crop=yes&k=c&w=270&h=270&itok=D7XYWDPU 1x, https://icon.widen.net/content/yu5rq6zqvl/web/finding-the-right-clinical-settings-early-clinical-card.jpg?crop=yes&k=c&w=270&h=270&itok=jkaOhp9n 2x" media="(min-width: 768px) and (max-width: 991px)" width="270" height="270"/> <source srcset="https://icon.widen.net/content/yu5rq6zqvl/web/finding-the-right-clinical-settings-early-clinical-card.jpg?crop=yes&k=c&w=325&h=325&itok=sc0fbAyL 1x, https://icon.widen.net/content/yu5rq6zqvl/web/finding-the-right-clinical-settings-early-clinical-card.jpg?crop=yes&k=c&w=650&h=650&itok=heoUubTB 2x" media="(min-width: 576px) and (max-width: 767px)" width="325" height="325"/> <source srcset="https://icon.widen.net/content/yu5rq6zqvl/web/finding-the-right-clinical-settings-early-clinical-card.jpg?crop=yes&k=c&w=515&h=515&itok=YOXT3vTg 1x, https://icon.widen.net/content/yu5rq6zqvl/web/finding-the-right-clinical-settings-early-clinical-card.jpg?crop=yes&k=c&w=515&h=515&itok=YOXT3vTg 2x" media="(max-width: 575px)" width="515" height="515"/> <img src="https://icon.widen.net/content/yu5rq6zqvl/web/finding-the-right-clinical-settings-early-clinical-card.jpg?crop=yes&k=c&w=515&h=515&itok=YOXT3vTg" width="515" height="515" alt="finding-the-right-clinical-settings-early-clinical-card" title="finding-the-right-clinical-settings-early-clinical-card" loading="lazy" /> </picture> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div id="db9bc77c-227b-4093-88e5-1fe52705cc4a"> <div class="gradient-bg-icon-green-left"> <div class="container-fluid container-fluid--xl text-and-picture-wrapper tc-light"> <div class="row"> <div class="col-sm"> <div class="text-picture-wrapper"> <div class="text-picture text-picture--text-only text-left with-separator--top"> <div> <div class="text-picture__text"> <h2>Case studies</h2> <h3> </h3> <div><p>Explore our case studies showcasing innovative early clinical solutions to advance your drug development strategy. ICON is committed to excellence and scientific expertise in early clinical drug development.</p></div> <a class="btn btn-primary btn-md" href="/solutions/all-case-studies/early-clinical-case-studies" target="_self">Learn more</a> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div id="3233b904-7bc1-49f3-bfaa-9fdcda0975d2"> <div class="container-fluid container-fluid--xl text-and-picture-wrapper "> <div class="row"> <div class="col-sm"> <div class="text-picture text-left text-picture--picture-left-text-right text-left "> <div class="container-fluid container-fluid--xl"> <div class="row"> <div class="col-sm-6"> <div class="text-picture__picture"> <div class="text-picture-link-wrapper"> <div> <div> <picture> <source srcset="https://icon.widen.net/content/jypi4jcfbg/web/Thumbnail_biotech_whitepaper.jpeg?crop=yes&w=2048&h=1251&a=0,0&itok=09xS0pDp 1x, https://icon.widen.net/content/jypi4jcfbg/web/Thumbnail_biotech_whitepaper.jpeg?crop=yes&w=2048&h=1251&a=0,0&itok=09xS0pDp 2x" media="(min-width: 1400px)" width="555" height="339"/> <source srcset="https://icon.widen.net/content/jypi4jcfbg/web/Thumbnail_biotech_whitepaper.jpeg?crop=yes&w=2048&h=1251&a=0,0&itok=09xS0pDp 1x, https://icon.widen.net/content/jypi4jcfbg/web/Thumbnail_biotech_whitepaper.jpeg?crop=yes&w=2048&h=1251&a=0,0&itok=09xS0pDp 2x" media="(min-width: 1200px)" width="555" height="339"/> <source srcset="https://icon.widen.net/content/jypi4jcfbg/web/Thumbnail_biotech_whitepaper.jpeg?crop=yes&w=2048&h=1251&a=0,0&itok=09xS0pDp 1x, https://icon.widen.net/content/jypi4jcfbg/web/Thumbnail_biotech_whitepaper.jpeg?crop=yes&w=2048&h=1251&a=0,0&itok=09xS0pDp 2x" media="(min-width: 992px) and (max-width: 1199px)" width="555" height="339"/> <source srcset="https://icon.widen.net/content/jypi4jcfbg/web/Thumbnail_biotech_whitepaper.jpeg?crop=yes&w=2048&h=1251&a=0,0&itok=09xS0pDp 1x, https://icon.widen.net/content/jypi4jcfbg/web/Thumbnail_biotech_whitepaper.jpeg?crop=yes&w=2048&h=1251&a=0,0&itok=09xS0pDp 2x" media="(min-width: 768px) and (max-width: 991px)" width="555" height="339"/> <source srcset="https://icon.widen.net/content/jypi4jcfbg/web/Thumbnail_biotech_whitepaper.jpeg?crop=yes&w=2048&h=1251&a=0,0&itok=09xS0pDp 1x, https://icon.widen.net/content/jypi4jcfbg/web/Thumbnail_biotech_whitepaper.jpeg?crop=yes&w=2048&h=1251&a=0,0&itok=09xS0pDp 2x" media="(min-width: 576px) and (max-width: 767px)" width="555" height="339"/> <source srcset="https://icon.widen.net/content/jypi4jcfbg/web/Thumbnail_biotech_whitepaper.jpeg?crop=yes&w=2048&h=1251&a=0,0&itok=09xS0pDp 1x, https://icon.widen.net/content/jypi4jcfbg/web/Thumbnail_biotech_whitepaper.jpeg?crop=yes&w=2048&h=1251&a=0,0&itok=09xS0pDp 2x" media="(max-width: 575px)" width="555" height="339"/> <img src="https://icon.widen.net/content/jypi4jcfbg/web/Thumbnail_biotech_whitepaper.jpeg" width="4440" height="2713" alt="Early phase challenges for biotechs_whitepaper" title="Early phase challenges for biotechs_whitepaper" loading="lazy" /> </picture> </div> </div> </div> </div> <div class="text-picture__picture-comment"> </div> </div> <div class="text-picture__text-wrapper col-sm-6"> <div class="text-picture__text"> <h2>Early phase challenges for biotechs</h2> <div><p dir="ltr">This whitepaper explores the growing challenges facing biotech during early phase drug development, and how these can be navigated to ensure the best possible outcomes.</p></div> <a class="btn btn-primary btn-md" href="/sectors/biotech/early-phase-challenges-biotechs" target="_self" title="Read the whitepaper"> Read the whitepaper </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div id="5a814930-ea7c-4083-9ab8-a36ed8bd5cad"> <div class="container-fluid container-fluid--xl text-and-picture-wrapper "> <div class="row"> <div class="col-sm"> <div class="text-picture text-left text-picture--text-left-picture-right text-left "> <div class="container-fluid container-fluid--xl"> <div class="row"> <div class="col-sm-6 order-sm-2"> <div class="text-picture__picture"> <div class="text-picture-link-wrapper"> <div> <div> <picture> <source srcset="https://icon.widen.net/content/n2biidf8vx/web/Surveyreport_Thumbnail%20(landscape)_1.jpeg?crop=yes&w=2048&h=1251&a=0,0&itok=QVxXQDKL 1x, https://icon.widen.net/content/n2biidf8vx/web/Surveyreport_Thumbnail%20(landscape)_1.jpeg?crop=yes&w=2048&h=1251&a=0,0&itok=QVxXQDKL 2x" media="(min-width: 1400px)" width="555" height="339"/> <source srcset="https://icon.widen.net/content/n2biidf8vx/web/Surveyreport_Thumbnail%20(landscape)_1.jpeg?crop=yes&w=2048&h=1251&a=0,0&itok=QVxXQDKL 1x, https://icon.widen.net/content/n2biidf8vx/web/Surveyreport_Thumbnail%20(landscape)_1.jpeg?crop=yes&w=2048&h=1251&a=0,0&itok=QVxXQDKL 2x" media="(min-width: 1200px)" width="555" height="339"/> <source srcset="https://icon.widen.net/content/n2biidf8vx/web/Surveyreport_Thumbnail%20(landscape)_1.jpeg?crop=yes&w=2048&h=1251&a=0,0&itok=QVxXQDKL 1x, https://icon.widen.net/content/n2biidf8vx/web/Surveyreport_Thumbnail%20(landscape)_1.jpeg?crop=yes&w=2048&h=1251&a=0,0&itok=QVxXQDKL 2x" media="(min-width: 992px) and (max-width: 1199px)" width="555" height="339"/> <source srcset="https://icon.widen.net/content/n2biidf8vx/web/Surveyreport_Thumbnail%20(landscape)_1.jpeg?crop=yes&w=2048&h=1251&a=0,0&itok=QVxXQDKL 1x, https://icon.widen.net/content/n2biidf8vx/web/Surveyreport_Thumbnail%20(landscape)_1.jpeg?crop=yes&w=2048&h=1251&a=0,0&itok=QVxXQDKL 2x" media="(min-width: 768px) and (max-width: 991px)" width="555" height="339"/> <source srcset="https://icon.widen.net/content/n2biidf8vx/web/Surveyreport_Thumbnail%20(landscape)_1.jpeg?crop=yes&w=2048&h=1251&a=0,0&itok=QVxXQDKL 1x, https://icon.widen.net/content/n2biidf8vx/web/Surveyreport_Thumbnail%20(landscape)_1.jpeg?crop=yes&w=2048&h=1251&a=0,0&itok=QVxXQDKL 2x" media="(min-width: 576px) and (max-width: 767px)" width="555" height="339"/> <source srcset="https://icon.widen.net/content/n2biidf8vx/web/Surveyreport_Thumbnail%20(landscape)_1.jpeg?crop=yes&w=2048&h=1251&a=0,0&itok=QVxXQDKL 1x, https://icon.widen.net/content/n2biidf8vx/web/Surveyreport_Thumbnail%20(landscape)_1.jpeg?crop=yes&w=2048&h=1251&a=0,0&itok=QVxXQDKL 2x" media="(max-width: 575px)" width="555" height="339"/> <img src="https://icon.widen.net/content/n2biidf8vx/web/Surveyreport_Thumbnail%20(landscape)_1.jpeg" width="3331" height="2035" alt="survey report" title="survey report" loading="lazy" /> </picture> </div> </div> </div> </div> <div class="text-picture__picture-comment"> </div> </div> <div class="text-picture__text-wrapper col-sm-6 col-sm-pull-6"> <div class="text-picture__text"> <h2>ICON survey report: Early phase development - understanding key obstacles for biotechs in 2024</h2> <div><p dir="ltr">ICON conducted a survey of 149 small and medium biotechs to understand the challenges they are currently experiencing in early phase drug development.</p></div> <a class="btn btn-primary btn-md" href="/sectors/biotech/early-phase-development-understanding-key-obstacles-biotechs-2024" target="_self" title="Read the survey report"> Read the survey report </a> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div id="bb76cb37-2093-4702-a688-5cf2b0d8f19f"> <div class="container-fluid container-fluid--xl text-and-picture-wrapper "> <div class="row"> <div class="col-sm"> <div class="text-picture text-left text-picture--picture-left-text-right text-left "> <div class="container-fluid container-fluid--xl"> <div class="row"> <div class="col-sm-4"> <div class="text-picture__picture"> <div class="text-picture-link-wrapper"> <div> <div> <picture> <source srcset="https://icon.widen.net/content/udq9mbr7rs/web/ISR%20logo%20landscape.png?crop=yes&w=1110&h=678&a=0,0&itok=z70HOBMA 1x, https://icon.widen.net/content/udq9mbr7rs/web/ISR%20logo%20landscape.png?crop=yes&w=1110&h=678&a=0,0&itok=z70HOBMA 2x" media="(min-width: 1400px)" width="555" height="339"/> <source srcset="https://icon.widen.net/content/udq9mbr7rs/web/ISR%20logo%20landscape.png?crop=yes&w=1110&h=678&a=0,0&itok=z70HOBMA 1x, https://icon.widen.net/content/udq9mbr7rs/web/ISR%20logo%20landscape.png?crop=yes&w=1110&h=678&a=0,0&itok=z70HOBMA 2x" media="(min-width: 1200px)" width="555" height="339"/> <source srcset="https://icon.widen.net/content/udq9mbr7rs/web/ISR%20logo%20landscape.png?crop=yes&w=1110&h=678&a=0,0&itok=z70HOBMA 1x, https://icon.widen.net/content/udq9mbr7rs/web/ISR%20logo%20landscape.png?crop=yes&w=1110&h=678&a=0,0&itok=z70HOBMA 2x" media="(min-width: 992px) and (max-width: 1199px)" width="555" height="339"/> <source srcset="https://icon.widen.net/content/udq9mbr7rs/web/ISR%20logo%20landscape.png?crop=yes&w=1110&h=678&a=0,0&itok=z70HOBMA 1x, https://icon.widen.net/content/udq9mbr7rs/web/ISR%20logo%20landscape.png?crop=yes&w=1110&h=678&a=0,0&itok=z70HOBMA 2x" media="(min-width: 768px) and (max-width: 991px)" width="555" height="339"/> <source srcset="https://icon.widen.net/content/udq9mbr7rs/web/ISR%20logo%20landscape.png?crop=yes&w=1110&h=678&a=0,0&itok=z70HOBMA 1x, https://icon.widen.net/content/udq9mbr7rs/web/ISR%20logo%20landscape.png?crop=yes&w=1110&h=678&a=0,0&itok=z70HOBMA 2x" media="(min-width: 576px) and (max-width: 767px)" width="555" height="339"/> <source srcset="https://icon.widen.net/content/udq9mbr7rs/web/ISR%20logo%20landscape.png?crop=yes&w=1110&h=678&a=0,0&itok=z70HOBMA 1x, https://icon.widen.net/content/udq9mbr7rs/web/ISR%20logo%20landscape.png?crop=yes&w=1110&h=678&a=0,0&itok=z70HOBMA 2x" media="(max-width: 575px)" width="555" height="339"/> <img src="https://icon.widen.net/content/udq9mbr7rs/web/ISR%20logo%20landscape.png" width="1110" height="678" alt="ISR logo landscape" title="ISR logo landscape" loading="lazy" /> </picture> </div> </div> </div> </div> <div class="text-picture__picture-comment"> </div> </div> <div class="text-picture__text-wrapper col-sm-8"> <div class="text-picture__text"> <div><p>In the latest<a href="https://isrreports.com/reports/2024-phase-i-cro-benchmarking/" target="_blank"> ISR Phase 1 CRO benchmarking survey</a> ICON outperforms other large CROs in 16 of the 17 operational metrics, with a significant lead differential in 11. We received our highest performance ratings on data quality, operational excellence, technology for real-time access to data, and patient/volunteer recruitment. Overall satisfaction with ICON for Phase 1 services has remained at last year’s all-time high and is amongst the very best of the large CROs. These results reflect our commitment to providing the very best early clinical drug development solutions.</p></div> </div> </div> </div> </div> </div> </div> </div> </div> </div><div id="8abbb370-1dab-4cd9-b1ef-8b6f4d64263b"> <div class="group group--with-carousel bg-white content-visibility--auto contain-intrinsic-size--400 related-content-carousel"> <div class="container-fluid container-fluid--xl"> <h2 class="group__title"> Related Information </h2> <div class="carousel--standard carousel--standard-1-3-4"> <a class="carousel__item block-link" href="https://www2.iconplc.com/Fact_Sheet_Early_Phase_Development" target="_self"> <div class="card card--with-solid-bg card--with-solid-bg-cream" data-mh="related-content"> <div class="card-body"> <span aria-hidden="true" class="icon icon-download"></span> <span class="badge badge--with-arrow">Factsheet</span> <h4 class="card-title m-0"> Early Clinical Development </h4> </div> </div> </a> <a class="carousel__item block-link" href="https://www2.iconplc.com/case-study-multiple-sclerosis-biosimilars" target="_self"> <div class="card card--with-solid-bg card--with-solid-bg-purple" data-mh="related-content"> <div class="card-body"> <span aria-hidden="true" class="icon icon-download"></span> <span class="badge badge--with-arrow">Case Study</span> <h4 class="card-title m-0"> Multinational phase 1 study for a biosimilar product for the treatment of MS </h4> </div> </div> </a> <a class="carousel__item block-link" href="https://www.iconplc.com/insights/blog/2024/07/19/streamlining-clinical-trial-submissions-under-eu-ctr" target="_self"> <div class="card card--with-solid-bg card--with-solid-bg-yellow-green" 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